Free Radicals

Highly reactive molecules with an unsatisfied electron valence pair. Free radicals are produced in both normal and pathological processes. They are proven or suspected agents of tissue damage in a wide variety of circumstances including radiation, damage from environment chemicals, and aging. Natural and pharmacological prevention of free radical damage is being actively investigated.
DrugDrug NameDrug Indication
DB00435Nitric OxideFor the treatment of term and near-term (>34 weeks) neonates with hypoxic respiratory failure
DB03866Prostaglandin G2Not Available
DB06697ArtemetherArtemether and lumefantrine combination therapy is indicated for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum, including malaria acquired in chloroquine-resistant areas. May also be used to treat uncomplicated malaria when the Plasmodium species has not been identified. Indicated for use in adults and children greater than 5 kg.
DB09274ArtesunateFor the treatment of severe malaria caused by *Plasmodium falciparum* in adults and children [L891]
DB11091Hydrogen peroxideIndicated to be used as a disinfectant and sterilizer.
DB11123HypochloriteIndicated for over-the-counter use as a disinfectant agent in the sodium hypochlorite form.
DB11129Carbamide peroxideIndicated as a dental bleaching agent. Indicated as an oral wound healing agent in oral mucosal injuries. Indicated as an aid in the removal of hardened ear wax.
DB11638ArtenimolFor the treatment of uncomplicated *Plasmodium falciparum* infection in adults, children, and infants aged 6 months and up weighing over 5 kg [FDA Label]. Used in combination with [DB13941].
DB11809ArtefenomelNot Available
DB12449TempolNot Available
DB13132ArtemisininNot Available
DB13486Magnesium peroxideNot Available
DB13851ArtemotilNot Available
DB14135Hypochlorous acidNot Available
DrugDrug NameTargetType
DB00435Nitric OxideGuanylate cyclase soluble subunit alpha-2target
DB00435Nitric OxideAldehyde dehydrogenase, mitochondrialenzyme
DB00435Nitric OxideCytochrome P450 1A2enzyme
DB00435Nitric OxideCytochrome P450 2B6enzyme
DB00435Nitric OxideCytochrome P450 3A4enzyme
DB00435Nitric OxideMetallothionein-1Atarget
DB00435Nitric OxideIndoleamine 2,3-dioxygenase 1target
DB03866Prostaglandin G2Prostaglandin G/H synthase 2target
DB06697ArtemetherCytochrome P450 3A4enzyme
DB06697ArtemetherCytochrome P450 3A5enzyme
DB06697ArtemetherCytochrome P450 2B6enzyme
DB06697ArtemetherCytochrome P450 2C9enzyme
DB06697ArtemetherCytochrome P450 2C19enzyme
DB06697ArtemetherCytochrome P450 2D6enzyme
DB09274ArtesunateMalaria protein EXP-1target
DB09274ArtesunateCytochrome P450 2A6enzyme
DB09274ArtesunateCytochrome P450 3A4enzyme
DB11091Hydrogen peroxideGlutathione peroxidase 1enzyme
DB11091Hydrogen peroxideCatalaseenzyme
DB11091Hydrogen peroxideAlkaline phosphatase, placental-likeenzyme
DB11638ArtenimolActin, cytoplasmic 2target
DB11638ArtenimolAlpha-aminoadipic semialdehyde dehydrogenasetarget
DB11638ArtenimolAnnexin A2target
DB11638ArtenimolATP synthase subunit alpha, mitochondrialtarget
DB11638ArtenimolATP synthase subunit g, mitochondrialtarget
DB11638ArtenimolATP synthase subunit O, mitochondrialtarget
DB11638ArtenimolCalpastatintarget
DB11638ArtenimolT-complex protein 1 subunit gammatarget
DB11638ArtenimolCofilin-1target
DB11638ArtenimolChloride intracellular channel protein 1target
DB11638ArtenimolCysteine and glycine-rich protein 1target
DB11638ArtenimolDihydropyrimidinase-related protein 2target
DB11638ArtenimolDesmoplakintarget
DB11638ArtenimolElongation factor 1-alpha 1target
DB11638ArtenimolAlpha-enolasetarget
DB11638ArtenimolFilamin-Atarget
DB11638ArtenimolAlpha-ketoglutarate-dependent dioxygenase FTOtarget
DB11638ArtenimolGlucose-6-phosphate 1-dehydrogenasetarget
DB11638ArtenimolGlyceraldehyde-3-phosphate dehydrogenase, testis-specifictarget
DB11638ArtenimolGlucose-6-phosphate isomerasetarget
DB11638ArtenimolHeterogeneous nuclear ribonucleoproteins A2/B1target
DB11638ArtenimolHeterogeneous nuclear ribonucleoprotein D0target
DB11638ArtenimolHeterogeneous nuclear ribonucleoprotein Ktarget
DB11638ArtenimolHeterochromatin protein 1-binding protein 3target
DB11638ArtenimolHeat shock protein beta-1target
DB11638ArtenimolRas GTPase-activating-like protein IQGAP1target
DB11638ArtenimolFar upstream element-binding protein 2target
DB11638ArtenimolL-lactate dehydrogenase A chaintarget
DB11638ArtenimolL-lactate dehydrogenase B chaintarget
DB11638ArtenimolGalectin-1target
DB11638ArtenimolMicrotubule-associated protein 4target
DB11638ArtenimolMalate dehydrogenase, cytoplasmictarget
DB11638ArtenimolPuromycin-sensitive aminopeptidasetarget
DB11638ArtenimolProfilin-1target
DB11638ArtenimolPhosphoglycerate kinase 1target
DB11638ArtenimolPyruvate kinase PKMtarget
DB11638ArtenimolPeptidyl-prolyl cis-trans isomerase Atarget
DB11638ArtenimolPeroxiredoxin-1target
DB11638Artenimol60S ribosomal protein L10target
DB11638Artenimol60S ribosomal protein L14target
DB11638Artenimol60S ribosomal protein L18target
DB11638Artenimol60S ribosomal protein L23atarget
DB11638Artenimol60S ribosomal protein L35target
DB11638Artenimol60S ribosomal protein L4target
DB11638Artenimol40S ribosomal protein S13target
DB11638Artenimol40S ribosomal protein S17target
DB11638Artenimol40S ribosomal protein S18target
DB11638Artenimol40S ribosomal protein S19target
DB11638Artenimol40S ribosomal protein S28target
DB11638Artenimol40S ribosomal protein S5target
DB11638Artenimol40S ribosomal protein S6target
DB11638Artenimol40S ribosomal protein S8target
DB11638Artenimol40S ribosomal protein S9target
DB11638ArtenimolSplicing factor 1target
DB11638ArtenimolSplicing factor, proline- and glutamine-richtarget
DB11638ArtenimolSmall nuclear ribonucleoprotein Sm D2target
DB11638ArtenimolSignal recognition particle 14 kDa proteintarget
DB11638ArtenimolSerine/arginine-rich splicing factor 4target
DB11638ArtenimolTransgelintarget
DB11638ArtenimolTransgelin-2target
DB11638ArtenimolTriosephosphate isomerasetarget
DB11638ArtenimolTropomyosin alpha-1 chaintarget
DB11638ArtenimolTubulin alpha-1A chaintarget
DB11638ArtenimolVimentintarget
DB11638ArtenimolZyxintarget
DB11638ArtenimolHeat shock cognate 71 kDa proteintarget
DB11638ArtenimolTubulin beta-6 chaintarget
DB11638ArtenimolTubulin beta-4A chaintarget
DB11638ArtenimolTubulin beta chaintarget
DB11638ArtenimolFructose-bisphosphate aldolase Atarget
DB11638ArtenimolGlyceraldehyde-3-phosphate dehydrogenasetarget
DB11638ArtenimolCytochrome ctarget
DB11638ArtenimolPhosphoglycerate mutase 1target
DB11638ArtenimolMyosin-9target
DB11638ArtenimolProtein disulfide-isomerasetarget
DB11638ArtenimolProbable ATP-dependent RNA helicase DDX5target
DB11638ArtenimolSerine hydroxymethyltransferase, mitochondrialtarget
DB11638ArtenimolSpliceosome RNA helicase DDX39Btarget
DB11638ArtenimolNucleophosmintarget
DB11638ArtenimolTranslationally-controlled tumor protein homologtarget
DB11638ArtenimolP-type Ca2+-transporting ATPasetarget
DB11638ArtenimolOrnithine aminotransferasetarget
DB11638ArtenimolElongation factor 1-alphatarget
DB11638ArtenimolMultidrug resistance proteintarget
DB11638ArtenimolElongation factor 2target
DB11638ArtenimolActin-1target
DB11638ArtenimolGlyceraldehyde-3-phosphate dehydrogenasetarget
DB11638ArtenimolFructose-bisphosphate aldolasetarget
DB11638ArtenimolCell division cycle protein 48 homologue,putativetarget
DB11638ArtenimolHeat shock protein 90target
DB11638ArtenimolEukaryotic initiation factor 4Atarget
DB11638ArtenimolPyruvate kinasetarget
DB11638ArtenimolL-lactate dehydrogenasetarget
DB11638ArtenimolProtein disulfide-isomerasetarget
DB11638ArtenimolThioredoxin-related protein, putativetarget
DB11638ArtenimolSpermidine synthasetarget
DB11638ArtenimolProbable ATP-dependent 6-phosphofructokinasetarget
DB11638ArtenimolGlutamate dehydrogenasetarget
DB11638ArtenimolEndoplasmin homolog, putativetarget
DB11638ArtenimolHypoxanthine-guanine-xanthine phosphoribosyltransferasetarget
DB11638ArtenimolEnolasetarget
DB11638Artenimol40S ribosomal protein S3target
DB11638ArtenimolNon-SERCA-type Ca2+-transporting P-ATPasetarget
DB11638ArtenimolTubulin alpha chaintarget
DB11638ArtenimolKnob-associated histidine-rich proteintarget
DB11638ArtenimolS-adenosylmethionine synthasetarget
DB11638ArtenimolV-type H(+)-translocating pyrophosphatase, putativetarget
DB11638Artenimol60S ribosomal protein L4target
DB11638ArtenimolPhosphoethanolamine N-methyltransferasetarget
DB11638Artenimol40S ribosomal protein S3atarget
DB11638ArtenimolConserved Plasmodium membrane proteintarget
DB11638Artenimol60S ribosomal protein L3target
DB11638ArtenimolHigh molecular weight rhoptry protein 2target
DB11638ArtenimolSerine repeat antigen 5target
DB11638Artenimol40S ribosomal protein S19target
DB11638ArtenimolGlycophorin-binding proteintarget
DB11638ArtenimolCalcium-transporting ATPasetarget
DB11638ArtenimolV-type proton ATPase catalytic subunit Atarget
DB11638Artenimol60S ribosomal protein L2target
DB11638ArtenimolAcyl-CoA synthetasetarget
DB11638ArtenimolPlasmepsin IVtarget
DB11638ArtenimolPlasmepsin-1target
DB11638ArtenimolChloroquine resistance transportertarget
DB11638Artenimol14-3-3 proteintarget
DB11638ArtenimolIsoleucine--tRNA ligase, putativetarget
DB11638ArtenimolPlasmodium exported proteintarget
DB11638ArtenimolTubulin beta chaintarget
DB11638Artenimol60S ribosomal protein L27target
DB11638ArtenimolSec62, putativetarget
DB11638ArtenimolAutophagy-related protein 18, putativetarget
DB11638ArtenimolMature parasite-infected erythrocyte surface antigentarget
DB11638ArtenimolImportin-7, putativetarget
DB11638ArtenimolKaryopherin alphatarget
DB11638ArtenimolPeptidyl-prolyl cis-trans isomerasetarget
DB11638ArtenimolDnaJ protein, putativetarget
DB11638ArtenimolMerozoite surface protein 1target
DB11638ArtenimolGlutamate--tRNA ligasetarget
DB11638ArtenimolT-complex protein 1 subunit etatarget
DB11638ArtenimolPlasmepsin-2target
DB11638ArtenimolChaperone, putativetarget
DB11638ArtenimolRhoptry neck protein 3target
DB11638Artenimol40S ribosomal protein S5, putativetarget
DB11638ArtenimolSkeleton-binding protein 1target
DB11638ArtenimolPurine nucleotide phosphorylase, putativetarget
DB11638ArtenimolAdenosylhomocysteinasetarget
DB11638ArtenimolAdenosine deaminasetarget
DB11638ArtenimolMethionine--tRNA ligasetarget
DB11638ArtenimolCarbamoyl phosphate synthetasetarget
DB11638ArtenimolAspartate carbamoyltransferasetarget
DB11638ArtenimolSignal recognition particle receptor, beta subunittarget
DB11638ArtenimolParasite-infected erythrocyte surface proteintarget
DB11638ArtenimolCoatomer alpha subunit, putativetarget
DB11638ArtenimolHexokinasetarget
DB11638ArtenimolProteasome subunit alpha typetarget
DB11638ArtenimolHaloacid dehalogenase-like hydrolasetarget
DB11638ArtenimolInsulinase, putativetarget
DB11638Artenimol40S ribosomal protein S21target
DB11638ArtenimolUbiquitin-conjugating enzyme E2target
DB11638ArtenimolEukaryotic translation initiation factor 3 subunit Ctarget
DB11638Artenimol60S ribosomal protein L24, putativetarget
DB11638Artenimol60S ribosomal protein L23target
DB11638Artenimol60S ribosomal protein L17, putativetarget
DB11638ArtenimolNADP-specific glutamate dehydrogenasetarget
DB11638ArtenimolHAP proteintarget
DB11638ArtenimolHeat shock protein 110, putativetarget
DB11638Artenimol60S ribosomal protein L10, putativetarget
DB11638ArtenimolLysophospholipase, putativetarget
DB11638ArtenimolPolyadenylate-binding proteintarget
DB11638ArtenimolUbiquitin-60S ribosomal protein L40target
DB11638ArtenimolPhosphoribosylpyrophosphate synthetasetarget
DB11638ArtenimolThioredoxin peroxidase 1target
DB11638ArtenimolProtein transport protein SEC31target
DB11638ArtenimolDipeptidyl aminopeptidase 1target
DB11638ArtenimolRing-infected erythrocyte surface antigentarget
DB11638ArtenimolATP-dependent RNA helicase UAP56target
DB11638ArtenimolCalcium-dependent protein kinase 4target
DB11638ArtenimolGTP-binding nuclear protein Rantarget
DB11638ArtenimolNucleoside transporter 2target
DB11638ArtenimolAnamorsin homologtarget
DB11638ArtenimolGlutamine synthetase, putativetarget
DB11638Artenimol60S ribosomal protein L30e, putativetarget
DB11638ArtenimolCasein kinase 2, alpha subunittarget
DB11638ArtenimolThreonine--tRNA ligasetarget
DB11638ArtenimolcAMP-dependent protein kinase regulatory subunittarget
DB11638ArtenimolElongation factor 1-gamma, putativetarget
DB11638ArtenimolThioredoxin-like proteintarget
DB11638Artenimol60S ribosomal protein L21target
DB11638Artenimol60S ribosomal protein L14, putativetarget
DB11638ArtenimolInner membrane complex sub-compartment protein 3target
DB11638ArtenimolHSP40, subfamily A, putativetarget
DB11638ArtenimolPyridoxal 5'-phosphate synthase subunit Pdx1target
DB11638ArtenimolUDP-glucuronosyltransferase 1-9enzyme
DB11638ArtenimolUDP-glucuronosyltransferase 2B7enzyme
DB11638ArtenimolSerum albumintarget
DB11638ArtenimolCytochrome P450 2D6enzyme
DB11638ArtenimolCytochrome P450 2C19enzyme
DB13132ArtemisininCytochrome P450 2B6enzyme