Cough and Cold Preparations

DrugDrug NameDrug Indication
DB00003Dornase alfaUsed as adjunct therapy in the treatment of cystic fibrosis.
DB00318CodeineCodeine sulfate is a form of this drug that is commonly used. It is available in tablet form [FDA label] and indicated for the relief of mild to moderately severe pain, where the use of an opioid analgesic is appropriate [FDA label]. The solution form is used by itself or combined in a syrup with other drugs and is used as a cough suppressant in adults aged 18 and above [L5521], [L5524].
DB00742MannitolUsed for the promotion of diuresis before irreversible renal failure becomes established, the reduction of intracranial pressure, the treatment of cerebral edema, and the promotion of urinary excretion of toxic substances.
DB00868BenzonatateFor the symptomatic relief of cough. Has also been applied locally in the oral cavity in adults by releasing the drug from the liquid-filled capsules to provide oropharyngeal anesthesia for conscious intubation.
DB00874GuaifenesinGuaifenesin is an expectorant that is indicated for providing temporary symptomatic relief from congested chests and coughs which may be due to a cold, bronchitis, and/or other breathing illnesses [FDA Label, F4510, L6079].
DB00956HydrocodoneHydrocodone is indicated for the management of acute pain, sometimes in combination with [acetaminophen] or [ibuprofen], as well as the symptomatic treatment of the common cold and allergic rhinitis in combination with decongestants, antihistamines, and expectorants.[label,L7991]
DB01423SteproninStrepronin is a mucolytic (expectorant) drug.
DB01466EthylmorphineEthylmorphine is an analgesic used for pain relief.
DB01538AcetyldihydrocodeineNot Available
DB03852EucalyptolNot Available
DB04339CarbocisteineUsed to help relieve the symptoms of chronic obstructive pulmonary disorder (COPD) and bronchiectasis.
DB04822OxeladinNot Available
DB04837ClofedanolUsed in the treatment of dry cough.
DB05057ErdosteineFro the treatment of chronic bronchitis in adults.
DB06151AcetylcysteineAcetylcysteine is used mainly as a mucolytic and in the management of paracetamol (acetaminophen) overdose.
DB06174NoscapineInvestigated for use/treatment in lymphoma (non-hodgkin's), leukemia (lymphoid), cancer/tumors (unspecified), and multiple myeloma.
DB06439TyloxapolTyloxapol is an inhaled surfactant that assists in removing and liquefying and removing bronchopulmonary secretions with mucus and pus. Tyloxapol is administered either through nebulized solution or a stream of oxygen. Also investigated for use/treatment in cystic fibrosis and pediatric indications.
DB06742AmbroxolAmbroxol is indicated for secretolytic therapy in bronchoplmonary diseaes with abnormal mucus secretion and transport. It allows the mucus to be more easily cleared and ease a patient's breathing.
DB08939LetosteineNot Available
DB08944IsoaminileNot Available
DB08990EprazinoneNot Available
DB09002CloperastineNot Available
DB09004ClobutinolNot Available
DB09019BromhexineNot Available
DB09209PholcodinePholcodine is indicated as a cough suppressant for the temporary relief of non-productive dry cough. It is stated to present a required label indication of "temporary relief of dry cough."[L1200] Cough is the respiratory movement that occurs after an irritation signal is transmitted to the central nervous system and further stimulates the medulla oblongata. This stimulation causes a motor output that is sent through motoneurons to the respiratory muscles. A non-productive cough is a type of cough characterized by the absence of sputum, and it has a large inspiration that will cause continuous coughing.
DB11186PentoxyverineIndicated as a cough suppressant to relieve cough caused by the common cold, flu, bronchitis, and sinusitis [A32160].
DB11609NormethadoneFor use in the treatment of cough when other less potent treatments have failed [FDA Label].
DB12472LevodropropizineNot Available
DB13194Hedera helix leaf extractNot Available
DB13216OxolamineNot Available
DB13224PiperidioneNot Available
DB13239NeltenexineNot Available
DB13271Wood creosoteNot Available
DB13293IpecacIpecac is indicated as an emetic agent for the induction of vomiting in poisoning victims who ingested systemic poison in order to prevent absorption of the chemicals through the gastrointestinal tract. In low doses, ipecac was also used as an expectorant.[L2753] Reports have suggested that ipecac was vastly used in patients with eating disorders to produce vomiting.[T49]
DB13309BenproperineNot Available
DB13315SobrerolNot Available
DB13391LevoverbenoneNot Available
DB13397PrenoxdiazineNot Available
DB13436DroxypropineNot Available
DB13445NepinaloneNot Available
DB13458ThebaconNot Available
DB13473Antimony pentasulfideNot Available
DB13474TipepidineNot Available
DB13525Althea rootNot Available
DB13558MorclofoneNot Available
DB13564ZipeprolNot Available
DB13630BibenzoniumNot Available
DB13731ButamirateNot Available
DB13768DomiodolNot Available
DB13785DropropizineNot Available
DB13794DimethoxanateNot Available
DB13796DibunateNot Available
DB13810DimemorfanNot Available
DB13822MeprotixolNot Available
DB13825FedrilateNot Available
DB00514DextromethorphanFor treatment and relief of dry cough.
DB06715Potassium IodidePotassium Iodide is oral antithyroid agent used in the prevention of radioactive iodine uptake into the thyroid gland during a nuclear radiation emergency. Potassium Iodide may be used as an adjunct to other antithyroid agents in the treatment of hyperthyroidism and thyrotoxicosis and preoperatively to induce thyroid involution.
DB08796PipazethateFor the treatment of cough.
DB09110Coenzyme MMesna is a uroprotective agent and is used prophylactically to reduce ifosfamide and cyclophosphamide induced hemorrhagic cystitis.[A18572]
DB14749Polygala senega rootNot Available
DrugDrug NameTargetType
DB00003Dornase alfaDNAtarget
DB00318CodeineMu-type opioid receptortarget
DB00318CodeineDelta-type opioid receptortarget
DB00318CodeineKappa-type opioid receptortarget
DB00318CodeineCytochrome P450 2D6enzyme
DB00318CodeineCytochrome P450 3A4enzyme
DB00318CodeineSolute carrier family 22 member 1transporter
DB00318CodeineUDP-glucuronosyltransferase 2B7enzyme
DB00318CodeineUDP-glucuronosyltransferase 2B4enzyme
DB00742MannitolMultidrug resistance protein 1transporter
DB00742MannitolMannitol dehydrogenaseenzyme
DB00868BenzonatateSodium channel protein type 5 subunit alphatarget
DB00874GuaifenesinNMDA receptortarget
DB00956HydrocodoneMu-type opioid receptortarget
DB00956HydrocodoneDelta-type opioid receptortarget
DB00956HydrocodoneCytochrome P450 3A4enzyme
DB00956HydrocodoneCytochrome P450 2D6enzyme
DB00956HydrocodoneCytochrome P450 2B6enzyme
DB00956HydrocodoneCytochrome P450 2C19enzyme
DB00956HydrocodoneSigma non-opioid intracellular receptor 1target
DB01466EthylmorphineCytochrome P450 2D6enzyme
DB01466EthylmorphineNADPH--cytochrome P450 reductaseenzyme
DB01466EthylmorphineMu-type opioid receptortarget
DB01466EthylmorphineCytochrome P450 2B6enzyme
DB01466EthylmorphineCytochrome P450 3A4enzyme
DB04339CarbocisteineGlutathione S-transferase Ptarget
DB04837ClofedanolHistamine H1 receptortarget
DB05057ErdosteineAdenosine deaminaseenzyme
DB06151AcetylcysteineSolute carrier organic anion transporter family member 1B1transporter
DB06151AcetylcysteineNAPQI (N-acetyl-p-benzoquinone imine)target
DB06151AcetylcysteineSolute carrier family 22 member 6transporter
DB06151AcetylcysteineAminoacylase-1target
DB06151AcetylcysteineInhibitor of nuclear factor kappa-B kinase subunit alphatarget
DB06151AcetylcysteineInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB06151AcetylcysteineGlutathione synthetasetarget
DB06151AcetylcysteineCystine/glutamate transportertarget
DB06151AcetylcysteineGlutamate receptor ionotropic, NMDA 2Btarget
DB06151AcetylcysteineGlutamate receptor ionotropic, NMDA 1target
DB06151AcetylcysteineGlutamate receptor ionotropic, NMDA 2Atarget
DB06151AcetylcysteineGlutamate receptor ionotropic, NMDA 2Dtarget
DB06151AcetylcysteineGlutamate receptor ionotropic, NMDA 3Atarget
DB06174NoscapineSigma non-opioid intracellular receptor 1target
DB06174NoscapineCytochrome P450 2C9enzyme
DB06174NoscapineCytochrome P450 3A4enzyme
DB06439TyloxapolLipoprotein lipasetarget
DB06742AmbroxolCytochrome P450 3A4enzyme
DB09209PholcodineMu-type opioid receptortarget
DB09209PholcodineKappa-type opioid receptortarget
DB09209PholcodineDelta-type opioid receptortarget
DB11186PentoxyverineSigma non-opioid intracellular receptor 1target
DB11186PentoxyverinePotassium voltage-gated channel subfamily H member 2target
DB11186PentoxyverineVoltage-gated sodium channel alpha subunittarget
DB11186PentoxyverineKappa-type opioid receptortarget
DB11186PentoxyverineMu-type opioid receptortarget
DB13293IpecacCytochrome P450 2D6enzyme
DB13293IpecacCytochrome P450 3A4enzyme
DB00514DextromethorphanSigma non-opioid intracellular receptor 1target
DB00514DextromethorphanHCG20471, isoform CRA_ctarget
DB00514DextromethorphanNeuronal acetylcholine receptor subunit alpha-2target
DB00514DextromethorphanSodium-dependent serotonin transportertarget
DB00514DextromethorphanGlutamate receptor ionotropic, NMDA 3Atarget
DB00514DextromethorphanCytochrome P450 2D6enzyme
DB00514DextromethorphanCytochrome P450 3A4enzyme
DB00514DextromethorphanCytochrome P450 3A7enzyme
DB00514DextromethorphanCytochrome P450 2C9enzyme
DB00514DextromethorphanCytochrome P450 2B6enzyme
DB00514DextromethorphanCytochrome P450 2C19enzyme
DB00514DextromethorphanMembrane-associated progesterone receptor component 1target
DB00514DextromethorphanNeuronal acetylcholine receptor subunit alpha-3target
DB00514DextromethorphanNeuronal acetylcholine receptor subunit alpha-4target
DB00514DextromethorphanNeuronal acetylcholine receptor subunit beta-4target
DB00514DextromethorphanNeuronal acetylcholine receptor subunit beta-2target
DB00514DextromethorphanNeuronal acetylcholine receptor subunit alpha-7target
DB00514DextromethorphanMu-type opioid receptortarget
DB00514DextromethorphanDelta-type opioid receptortarget
DB00514DextromethorphanKappa-type opioid receptortarget
DB00514DextromethorphanNADPH oxidasetarget
DB00514DextromethorphanSodium-dependent noradrenaline transportertarget
DB06715Potassium IodideTyrosinetarget
DB09110Coenzyme MGlutathione reductase, mitochondrialenzyme