Cough and Cold Preparations

Cough and Cold Preparations
Accession Number
Not Available
ATC Classification
DrugDrug Description
Dornase alfaA synthetic form of human deoxyribonuclease I used to break down extracellular DNA in the lungs, a major source of mucous viscosity in cystic fibrosis.
CodeineAn opioid analgesic used to treat moderate to severe pain when the use of an opioid is indicated.
MannitolA sugar alcohol used to test for asthma, to reduce intracranial and intraocular pressure, and to measure glomerular filtration rate.
BenzonatateA non-narcotic oral antitussive drug used to suppress coughing.
GuaifenesinAn expectorant commonly found in OTC products for the symptomatic relief from congested chests and coughs associated with cold, bronchitis, and/or other breathing illnesses.
HydrocodoneAn opioid agonist used as an analgesic and antitussive agent.
SteproninStrepronin is a mucolytic (expectorant) drug.
EthylmorphineEthylmorphine is an analgesic used for pain relief.
AcetyldihydrocodeineNot Available
EucalyptolA common ingredient in mouthwash and cosmetics derived naturally from the eucalyptus plant that is frequently used to to improve symptoms of airway mucus hypersecretion.
CarbocisteineUsed to help relieve the symptoms of chronic obstructive pulmonary disorder (COPD) and bronchiectasis.
OxeladinWithdrawn from the Canadian, US, and UK markets in 1976 due to carcinogenicity.
ClofedanolAn antitussive used for the symptomatic relief of acute cough caused by minor throat and bronchial irritation.
ErdosteineFro the treatment of chronic bronchitis in adults.
AcetylcysteineA medication that can be used as a mucolytic in patients with certain lung conditions and as an antidote for acetaminophen overdose.
NoscapineInvestigated for use/treatment in lymphoma (non-hodgkin's), leukemia (lymphoid), cancer/tumors (unspecified), and multiple myeloma.
TyloxapolTyloxapol is an inhaled surfactant that assists in removing and liquefying and removing bronchopulmonary secretions with mucus and pus. Tyloxapol is administered either through nebulized solution or a stream of...
AmbroxolAmbroxol is indicated for secretolytic therapy in bronchoplmonary diseaes with abnormal mucus secretion and transport. It allows the mucus to be more easily cleared and ease a patient's breathing.
LetosteineLetosteine is a mucolytic used in the treatment of chronic bronchopneumopathies and related conditions.
IsoaminileIsoaminile, an antitussive drug with a structure similar to methadone, is also an anticholinergic with both antimuscarinic and antinicotinic properties.
EprazinoneEprazinone (trade name Eftapan) is a mucolytic drug, and relieves bronchospasms.
CloperastineCloperastine is a cough suppressant that acts on the central nervous system.
ClobutinolClobutinol is a cough suppressant that is withdrawn from the US and EU markets. Clobutinol may prolong the QT interval. In 2007, Clobutinol was determined to cause cardiac arrhythmia in...
BromhexineBromhexine is an expectorant/mucolytic agent. Bromhexine is not available in the United States. It is marketed under the trade name Bisolvon(R) in Germany, England, Belgium, France, Italy, Netherlands, Norway, Sweden,...
PholcodinePholcodine is indicated as a cough suppressant for the temporary relief of non-productive dry cough. It is stated to present a required label indication of "temporary relief of dry cough."...
PentoxyverineA medication used to suppress a cough in the common cold, flu, bronchitis, and sinusitis.
NormethadoneAn opioid antitussive used to treat a cough associated with inflamed mucosa.
LevodropropizineLevodropropizine is under investigation in clinical trial NCT01573663 (A Drug-Drug Interaction Study of Ambroxol and Levodropropizine).
Hedera helix leaf extractAn extract from Hedera helix leaf extract used in allergy testing.
OxolamineOxolamine is not approved in the USA, it may be marketed elsewhere internationally as a cough suppressant . It is listed as a prescription drug in New Zealand legislation ....
PiperidionePiperidione was cough medicine marketed by Roche under the trade name Sedulon.
NeltenexineNeltenexine is an elastase inhibitor. It may be useful for preventing pulmonary emphysema.
Wood creosoteNot Annotated
IpecacAn emetic agent used to induce vomiting in poisoning.
BenproperineNot Annotated
SobrerolNot Annotated
LevoverbenoneNot Annotated
PrenoxdiazineNot Annotated
DroxypropineNot Annotated
NepinaloneNot Annotated
ThebaconNot Annotated
Antimony pentasulfideNot Annotated
TipepidineNot Annotated
Althea rootNot Annotated
MorclofoneNot Annotated
ZipeprolNot Annotated
BibenzoniumNot Annotated
ButamirateNot Annotated
DomiodolNot Annotated
DropropizineNot Annotated
DimethoxanateNot Annotated
DibunateNot Annotated
DimemorfanNot Annotated
MeprotixolNot Annotated
FedrilateNot Annotated
DextromethorphanAn NMDA receptor antagonist used to treat cases of dry cough.
Potassium IodideAn oral antithyroid agent used for the prevention of radioactive iodine uptake into the thyroid gland during a nuclear radiation emergency.
PipazethateFor the treatment of cough.
Coenzyme MA uroprotective agent used for the reduction and prophylaxis of oxazaphosphorine-induced toxicity in the urinary tract.
Polygala senega rootNot Annotated
Drugs & Drug Targets
Dornase alfaDNAtarget
CodeineMu-type opioid receptortarget
CodeineDelta-type opioid receptortarget
CodeineKappa-type opioid receptortarget
CodeineCytochrome P450 2D6enzyme
CodeineCytochrome P450 3A4enzyme
CodeineSolute carrier family 22 member 1transporter
CodeineUDP-glucuronosyltransferase 2B7enzyme
CodeineUDP-glucuronosyltransferase 2B4enzyme
MannitolMannitol dehydrogenaseenzyme
BenzonatateSodium channel protein type 5 subunit alphatarget
GuaifenesinNMDA receptortarget
HydrocodoneMu-type opioid receptortarget
HydrocodoneDelta-type opioid receptortarget
HydrocodoneCytochrome P450 3A4enzyme
HydrocodoneCytochrome P450 2D6enzyme
HydrocodoneCytochrome P450 2B6enzyme
HydrocodoneCytochrome P450 2C19enzyme
HydrocodoneSigma non-opioid intracellular receptor 1target
EthylmorphineCytochrome P450 2D6enzyme
EthylmorphineNADPH--cytochrome P450 reductaseenzyme
EthylmorphineMu-type opioid receptortarget
EthylmorphineCytochrome P450 2B6enzyme
EthylmorphineCytochrome P450 3A4enzyme
CarbocisteineGlutathione S-transferase Ptarget
ClofedanolHistamine H1 receptortarget
ErdosteineAdenosine deaminaseenzyme
AcetylcysteineSolute carrier organic anion transporter family member 1B1transporter
AcetylcysteineNAPQI (N-acetyl-p-benzoquinone imine)target
AcetylcysteineSolute carrier family 22 member 6transporter
AcetylcysteineInhibitor of nuclear factor kappa-B kinase subunit alphatarget
AcetylcysteineInhibitor of nuclear factor kappa-B kinase subunit betatarget
AcetylcysteineGlutathione synthetasetarget
AcetylcysteineCystine/glutamate transportertarget
AcetylcysteineGlutamate receptor ionotropic, NMDA 2Btarget
AcetylcysteineGlutamate receptor ionotropic, NMDA 1target
AcetylcysteineGlutamate receptor ionotropic, NMDA 2Atarget
AcetylcysteineGlutamate receptor ionotropic, NMDA 2Dtarget
AcetylcysteineGlutamate receptor ionotropic, NMDA 3Atarget
NoscapineSigma non-opioid intracellular receptor 1target
NoscapineCytochrome P450 2C9enzyme
NoscapineCytochrome P450 3A4enzyme
TyloxapolLipoprotein lipasetarget
AmbroxolCytochrome P450 3A4enzyme
PholcodineMu-type opioid receptortarget
PholcodineKappa-type opioid receptortarget
PholcodineDelta-type opioid receptortarget
PentoxyverineSigma non-opioid intracellular receptor 1target
PentoxyverinePotassium voltage-gated channel subfamily H member 2target
PentoxyverineVoltage-gated sodium channel alpha subunittarget
PentoxyverineKappa-type opioid receptortarget
PentoxyverineMu-type opioid receptortarget
IpecacCytochrome P450 2D6enzyme
IpecacCytochrome P450 3A4enzyme
DextromethorphanSigma non-opioid intracellular receptor 1target
DextromethorphanHCG20471, isoform CRA_ctarget
DextromethorphanNeuronal acetylcholine receptor subunit alpha-2target
DextromethorphanSodium-dependent serotonin transportertarget
DextromethorphanGlutamate receptor ionotropic, NMDA 3Atarget
DextromethorphanCytochrome P450 2D6enzyme
DextromethorphanCytochrome P450 3A4enzyme
DextromethorphanCytochrome P450 3A7enzyme
DextromethorphanCytochrome P450 2C9enzyme
DextromethorphanCytochrome P450 2B6enzyme
DextromethorphanCytochrome P450 2C19enzyme
DextromethorphanMembrane-associated progesterone receptor component 1target
DextromethorphanNeuronal acetylcholine receptor subunit alpha-3target
DextromethorphanNeuronal acetylcholine receptor subunit alpha-4target
DextromethorphanNeuronal acetylcholine receptor subunit beta-4target
DextromethorphanNeuronal acetylcholine receptor subunit beta-2target
DextromethorphanNeuronal acetylcholine receptor subunit alpha-7target
DextromethorphanMu-type opioid receptortarget
DextromethorphanDelta-type opioid receptortarget
DextromethorphanKappa-type opioid receptortarget
DextromethorphanNADPH oxidasetarget
DextromethorphanSodium-dependent noradrenaline transportertarget
Potassium IodideTyrosinetarget
Coenzyme MGlutathione reductase, mitochondrialenzyme