Cough and Cold Preparations

DrugDrug NameDrug Description
DB00003Dornase alfaA synthetic form of human deoxyribonuclease I used to break down extracellular DNA in the lungs, a major source of mucous viscosity in cystic fibrosis.
DB00318CodeineAn opioid analgesic used to treat moderate to severe pain when the use of an opioid is indicated.
DB00742MannitolA sugar alcohol used to test for asthma, to reduce intracranial and intraocular pressure, and to measure glomerular filtration rate.
DB00868BenzonatateA non-narcotic oral antitussive drug used to suppress coughing.
DB00874GuaifenesinAn expectorant commonly found in OTC products for the symptomatic relief from congested chests and coughs associated with cold, bronchitis, and/or other breathing illnesses.
DB00956HydrocodoneAn opioid agonist used as an analgesic and antitussive agent.
DB01423SteproninStrepronin is a mucolytic (expectorant) drug.
DB01466EthylmorphineEthylmorphine is an analgesic used for pain relief.
DB01538AcetyldihydrocodeineNot Available
DB03852EucalyptolA common ingredient in mouthwash and cosmetics derived naturally from the eucalyptus plant that is frequently used to to improve symptoms of airway mucus hypersecretion.
DB04339CarbocisteineUsed to help relieve the symptoms of chronic obstructive pulmonary disorder (COPD) and bronchiectasis.
DB04822OxeladinWithdrawn from the Canadian, US, and UK markets in 1976 due to carcinogenicity.
DB04837ClofedanolAn antitussive used for the symptomatic relief of acute cough caused by minor throat and bronchial irritation.
DB05057ErdosteineFro the treatment of chronic bronchitis in adults.
DB06151AcetylcysteineA medication that can be used as a mucolytic in patients with certain lung conditions and as an antidote for acetaminophen overdose.
DB06174NoscapineInvestigated for use/treatment in lymphoma (non-hodgkin's), leukemia (lymphoid), cancer/tumors (unspecified), and multiple myeloma.
DB06439TyloxapolTyloxapol is an inhaled surfactant that assists in removing and liquefying and removing bronchopulmonary secretions with mucus and pus. Tyloxapol is administered either through nebulized solution or a stream of...
DB06742AmbroxolAmbroxol is indicated for secretolytic therapy in bronchoplmonary diseaes with abnormal mucus secretion and transport. It allows the mucus to be more easily cleared and ease a patient's breathing.
DB08939LetosteineLetosteine is a mucolytic used in the treatment of chronic bronchopneumopathies and related conditions.
DB08944IsoaminileIsoaminile, an antitussive drug with a structure similar to methadone, is also an anticholinergic with both antimuscarinic and antinicotinic properties.
DB08990EprazinoneEprazinone (trade name Eftapan) is a mucolytic drug, and relieves bronchospasms.
DB09002CloperastineCloperastine is a cough suppressant that acts on the central nervous system.
DB09004ClobutinolClobutinol is a cough suppressant that is withdrawn from the US and EU markets. Clobutinol may prolong the QT interval. In 2007, Clobutinol was determined to cause cardiac arrhythmia in...
DB09019BromhexineBromhexine is an expectorant/mucolytic agent. Bromhexine is not available in the United States. It is marketed under the trade name Bisolvon(R) in Germany, England, Belgium, France, Italy, Netherlands, Norway, Sweden,...
DB09209PholcodinePholcodine is indicated as a cough suppressant for the temporary relief of non-productive dry cough. It is stated to present a required label indication of "temporary relief of dry cough."...
DB11186PentoxyverineA medication used to suppress a cough in the common cold, flu, bronchitis, and sinusitis.
DB11609NormethadoneAn opioid antitussive used to treat a cough associated with inflamed mucosa.
DB12472LevodropropizineLevodropropizine is under investigation in clinical trial NCT01573663 (A Drug-Drug Interaction Study of Ambroxol and Levodropropizine).
DB13194Hedera helix leaf extractAn extract from Hedera helix leaf extract used in allergy testing.
DB13216OxolamineOxolamine is not approved in the USA, it may be marketed elsewhere internationally as a cough suppressant . It is listed as a prescription drug in New Zealand legislation ....
DB13224PiperidionePiperidione was cough medicine marketed by Roche under the trade name Sedulon.
DB13239NeltenexineNeltenexine is an elastase inhibitor. It may be useful for preventing pulmonary emphysema.
DB13271Wood creosoteNot Annotated
DB13293IpecacAn emetic agent used to induce vomiting in poisoning.
DB13309BenproperineNot Annotated
DB13315SobrerolNot Annotated
DB13391LevoverbenoneNot Annotated
DB13397PrenoxdiazineNot Annotated
DB13436DroxypropineNot Annotated
DB13445NepinaloneNot Annotated
DB13458ThebaconNot Annotated
DB13473Antimony pentasulfideNot Annotated
DB13474TipepidineNot Annotated
DB13525Althea rootNot Annotated
DB13558MorclofoneNot Annotated
DB13564ZipeprolNot Annotated
DB13630BibenzoniumNot Annotated
DB13731ButamirateNot Annotated
DB13768DomiodolNot Annotated
DB13785DropropizineNot Annotated
DB13794DimethoxanateNot Annotated
DB13796DibunateNot Annotated
DB13810DimemorfanNot Annotated
DB13822MeprotixolNot Annotated
DB13825FedrilateNot Annotated
DB00514DextromethorphanAn NMDA receptor antagonist used to treat cases of dry cough.
DB06715Potassium IodideAn oral antithyroid agent used for the prevention of radioactive iodine uptake into the thyroid gland during a nuclear radiation emergency.
DB08796PipazethateFor the treatment of cough.
DB09110Coenzyme MA uroprotective agent used for the reduction and prophylaxis of oxazaphosphorine-induced toxicity in the urinary tract.
DB14749Polygala senega rootNot Annotated
DrugDrug NameTargetType
DB00003Dornase alfaDNAtarget
DB00318CodeineMu-type opioid receptortarget
DB00318CodeineDelta-type opioid receptortarget
DB00318CodeineKappa-type opioid receptortarget
DB00318CodeineCytochrome P450 2D6enzyme
DB00318CodeineCytochrome P450 3A4enzyme
DB00318CodeineSolute carrier family 22 member 1transporter
DB00318CodeineUDP-glucuronosyltransferase 2B7enzyme
DB00318CodeineUDP-glucuronosyltransferase 2B4enzyme
DB00742MannitolP-glycoprotein 1transporter
DB00742MannitolMannitol dehydrogenaseenzyme
DB00868BenzonatateSodium channel protein type 5 subunit alphatarget
DB00868BenzonatateCholinesteraseenzyme
DB00874GuaifenesinNMDA receptortarget
DB00956HydrocodoneMu-type opioid receptortarget
DB00956HydrocodoneDelta-type opioid receptortarget
DB00956HydrocodoneCytochrome P450 3A4enzyme
DB00956HydrocodoneCytochrome P450 2D6enzyme
DB00956HydrocodoneCytochrome P450 2B6enzyme
DB00956HydrocodoneCytochrome P450 2C19enzyme
DB00956HydrocodoneSigma non-opioid intracellular receptor 1target
DB01466EthylmorphineCytochrome P450 2D6enzyme
DB01466EthylmorphineNADPH--cytochrome P450 reductaseenzyme
DB01466EthylmorphineMu-type opioid receptortarget
DB01466EthylmorphineCytochrome P450 2B6enzyme
DB01466EthylmorphineCytochrome P450 3A4enzyme
DB04339CarbocisteineGlutathione S-transferase Ptarget
DB04837ClofedanolHistamine H1 receptortarget
DB05057ErdosteineAdenosine deaminaseenzyme
DB06151AcetylcysteineSolute carrier organic anion transporter family member 1B1transporter
DB06151AcetylcysteineNAPQI (N-acetyl-p-benzoquinone imine)target
DB06151AcetylcysteineSolute carrier family 22 member 6transporter
DB06151AcetylcysteineAminoacylase-1target
DB06151AcetylcysteineInhibitor of nuclear factor kappa-B kinase subunit alphatarget
DB06151AcetylcysteineInhibitor of nuclear factor kappa-B kinase subunit betatarget
DB06151AcetylcysteineGlutathione synthetasetarget
DB06151AcetylcysteineCystine/glutamate transportertarget
DB06151AcetylcysteineGlutamate receptor ionotropic, NMDA 2Btarget
DB06151AcetylcysteineGlutamate receptor ionotropic, NMDA 1target
DB06151AcetylcysteineGlutamate receptor ionotropic, NMDA 2Atarget
DB06151AcetylcysteineGlutamate receptor ionotropic, NMDA 2Dtarget
DB06151AcetylcysteineGlutamate receptor ionotropic, NMDA 3Atarget
DB06174NoscapineSigma non-opioid intracellular receptor 1target
DB06174NoscapineCytochrome P450 2C9enzyme
DB06174NoscapineCytochrome P450 3A4enzyme
DB06439TyloxapolLipoprotein lipasetarget
DB06742AmbroxolCytochrome P450 3A4enzyme
DB09209PholcodineMu-type opioid receptortarget
DB09209PholcodineKappa-type opioid receptortarget
DB09209PholcodineDelta-type opioid receptortarget
DB11186PentoxyverineSigma non-opioid intracellular receptor 1target
DB11186PentoxyverinePotassium voltage-gated channel subfamily H member 2target
DB11186PentoxyverineVoltage-gated sodium channel alpha subunittarget
DB11186PentoxyverineKappa-type opioid receptortarget
DB11186PentoxyverineMu-type opioid receptortarget
DB13293IpecacCytochrome P450 2D6enzyme
DB13293IpecacCytochrome P450 3A4enzyme
DB00514DextromethorphanSigma non-opioid intracellular receptor 1target
DB00514DextromethorphanHCG20471, isoform CRA_ctarget
DB00514DextromethorphanNeuronal acetylcholine receptor subunit alpha-2target
DB00514DextromethorphanSodium-dependent serotonin transportertarget
DB00514DextromethorphanGlutamate receptor ionotropic, NMDA 3Atarget
DB00514DextromethorphanCytochrome P450 2D6enzyme
DB00514DextromethorphanCytochrome P450 3A4enzyme
DB00514DextromethorphanCytochrome P450 3A7enzyme
DB00514DextromethorphanCytochrome P450 2C9enzyme
DB00514DextromethorphanCytochrome P450 2B6enzyme
DB00514DextromethorphanCytochrome P450 2C19enzyme
DB00514DextromethorphanMembrane-associated progesterone receptor component 1target
DB00514DextromethorphanNeuronal acetylcholine receptor subunit alpha-3target
DB00514DextromethorphanNeuronal acetylcholine receptor subunit alpha-4target
DB00514DextromethorphanNeuronal acetylcholine receptor subunit beta-4target
DB00514DextromethorphanNeuronal acetylcholine receptor subunit beta-2target
DB00514DextromethorphanNeuronal acetylcholine receptor subunit alpha-7target
DB00514DextromethorphanMu-type opioid receptortarget
DB00514DextromethorphanDelta-type opioid receptortarget
DB00514DextromethorphanKappa-type opioid receptortarget
DB00514DextromethorphanNADPH oxidasetarget
DB00514DextromethorphanSodium-dependent noradrenaline transportertarget
DB06715Potassium IodideTyrosinetarget
DB09110Coenzyme MGlutathione reductase, mitochondrialenzyme