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Identification
NameMedrysone
Accession NumberDB00253  (APRD01091)
TypeSmall Molecule
GroupsApproved
DescriptionMedrysone is a corticosteroid used in ophthalmology. [Wikipedia]
Structure
Thumb
Synonyms
11beta-Hydroxy-6alpha-methylpregn-4-ene-3,20-dione
HMS
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
HmsSolution / drops1 %OphthalmicAllergan Inc1969-12-312011-08-04Canada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNIID2UFC189XF
CAS number2668-66-8
WeightAverage: 344.4877
Monoisotopic: 344.23514489
Chemical FormulaC22H32O3
InChI KeyGZENKSODFLBBHQ-ILSZZQPISA-N
InChI
InChI=1S/C22H32O3/c1-12-9-15-17-6-5-16(13(2)23)22(17,4)11-19(25)20(15)21(3)8-7-14(24)10-18(12)21/h10,12,15-17,19-20,25H,5-9,11H2,1-4H3/t12-,15-,16+,17-,19-,20+,21-,22+/m0/s1
IUPAC Name
(1S,2R,8S,10S,11S,14S,15S,17S)-14-acetyl-17-hydroxy-2,8,15-trimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-5-one
SMILES
[H][C@@]12CC[[email protected]](C(C)=O)[C@@]1(C)C[[email protected]](O)[C@@]1([H])[C@@]2([H])C[[email protected]](C)C2=CC(=O)CC[C@]12C
Pharmacology
IndicationFor the treatment of allergic conjunctivitis, vernal conjunctivitis, episcleritis, and epinephrine sensitivity.
Structured Indications Not Available
PharmacodynamicsMedrysone is a topical anti-inflammatory corticoidsteroids for ophthalmic use. In patients with increased intraocular pressure and in those susceptible to a rise in intraocular pressure, there is less effect on pressure with medrysone than with dexamethasone or betamethasone. Corticoidsteroids inhibit the edema, fibrin deposition, capillary dilation, and phagocytic migration of the acute inflammatory response, as well as capillary proliferation, deposition of collagen, and scar formation.
Mechanism of actionThere is no generally accepted explanation for the mechanism of action of ocular corticosteroids. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. Initially, the drug binds to the glucocorticoid receptor in the cytosol. This migrates to the nucleus and binds to genetic elements which cause activation and repression of the involved genes in the inflammatory pathway.
TargetKindPharmacological actionActionsOrganismUniProt ID
Glucocorticoid receptorProteinyes
agonist
HumanP04150 details
Related Articles
AbsorptionRapidly absorbed following oral administration.
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
1,10-PhenanthrolineThe risk or severity of adverse effects can be increased when Medrysone is combined with 1,10-Phenanthroline.Experimental
AceclofenacThe risk or severity of adverse effects can be increased when Aceclofenac is combined with Medrysone.Approved
AcetovanilloneThe risk or severity of adverse effects can be increased when Acetovanillone is combined with Medrysone.Investigational
Acetylsalicylic acidThe risk or severity of adverse effects can be increased when Acetylsalicylic acid is combined with Medrysone.Approved, Vet Approved
AdapaleneThe risk or severity of adverse effects can be increased when Adapalene is combined with Medrysone.Approved
AldesleukinMedrysone may decrease the antineoplastic activities of Aldesleukin.Approved
ALT-110The risk or severity of adverse effects can be increased when Medrysone is combined with ALT-110.Investigational
Aluminum hydroxideThe bioavailability of Medrysone can be decreased when combined with Aluminum hydroxide.Approved
Aluminum phosphateThe bioavailability of Medrysone can be decreased when combined with Aluminum phosphate.Approved
AmbenoniumThe risk or severity of adverse effects can be increased when Medrysone is combined with Ambenonium.Approved
Aminosalicylic AcidThe risk or severity of adverse effects can be increased when Aminosalicylic Acid is combined with Medrysone.Approved
AmiodaroneThe serum concentration of Medrysone can be increased when it is combined with Amiodarone.Approved, Investigational
Amphotericin BMedrysone may increase the hypokalemic activities of Amphotericin B.Approved, Investigational
AnisodamineThe risk or severity of adverse effects can be increased when Anisodamine is combined with Medrysone.Investigational
AntipyrineThe risk or severity of adverse effects can be increased when Antipyrine is combined with Medrysone.Approved
ApremilastThe risk or severity of adverse effects can be increased when Apremilast is combined with Medrysone.Approved, Investigational
AprepitantThe serum concentration of Medrysone can be increased when it is combined with Aprepitant.Approved, Investigational
AtazanavirThe serum concentration of Medrysone can be increased when it is combined with Atazanavir.Approved, Investigational
Atracurium besylateAtracurium besylate may increase the adverse neuromuscular activities of Medrysone.Approved
AzapropazoneThe risk or severity of adverse effects can be increased when Azapropazone is combined with Medrysone.Withdrawn
AzelastineThe risk or severity of adverse effects can be increased when Azelastine is combined with Medrysone.Approved
BalsalazideThe risk or severity of adverse effects can be increased when Balsalazide is combined with Medrysone.Approved, Investigational
BazedoxifeneThe serum concentration of Medrysone can be increased when it is combined with Bazedoxifene.Approved, Investigational
BendroflumethiazideMedrysone may increase the hypokalemic activities of Bendroflumethiazide.Approved
BenoxaprofenThe risk or severity of adverse effects can be increased when Benoxaprofen is combined with Medrysone.Withdrawn
Benzoic AcidThe therapeutic efficacy of Benzoic Acid can be decreased when used in combination with Medrysone.Approved
Betulinic AcidThe risk or severity of adverse effects can be increased when Betulinic Acid is combined with Medrysone.Investigational
Bismuth SubcitrateThe bioavailability of Medrysone can be decreased when combined with Bismuth Subcitrate.Approved
BoceprevirThe serum concentration of Medrysone can be increased when it is combined with Boceprevir.Approved
BromfenacThe risk or severity of adverse effects can be increased when Bromfenac is combined with Medrysone.Approved
BucillamineThe risk or severity of adverse effects can be increased when Bucillamine is combined with Medrysone.Investigational
BumetanideMedrysone may increase the hypokalemic activities of Bumetanide.Approved
CalcitriolThe therapeutic efficacy of Calcitriol can be decreased when used in combination with Medrysone.Approved, Nutraceutical
Calcium carbonateThe bioavailability of Medrysone can be decreased when combined with Calcium carbonate.Approved
CarbamazepineThe serum concentration of Medrysone can be decreased when it is combined with Carbamazepine.Approved, Investigational
CarprofenThe risk or severity of adverse effects can be increased when Carprofen is combined with Medrysone.Approved, Vet Approved, Withdrawn
CastanospermineThe risk or severity of adverse effects can be increased when Castanospermine is combined with Medrysone.Experimental
CDX-110The risk or severity of adverse effects can be increased when Medrysone is combined with CDX-110.Investigational
CelecoxibThe risk or severity of adverse effects can be increased when Celecoxib is combined with Medrysone.Approved, Investigational
CeritinibMedrysone may increase the hyperglycemic activities of Ceritinib.Approved
ChloroquineThe risk or severity of adverse effects can be increased when Chloroquine is combined with Medrysone.Approved, Vet Approved
ChlorothiazideMedrysone may increase the hypokalemic activities of Chlorothiazide.Approved, Vet Approved
ChlorotrianiseneThe serum concentration of Medrysone can be increased when it is combined with Chlorotrianisene.Withdrawn
ChlorthalidoneMedrysone may increase the hypokalemic activities of Chlorthalidone.Approved
CholestyramineCholestyramine can cause a decrease in the absorption of Medrysone resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
CinoxacinThe risk or severity of adverse effects can be increased when Medrysone is combined with Cinoxacin.Approved, Withdrawn
CiprofloxacinThe risk or severity of adverse effects can be increased when Medrysone is combined with Ciprofloxacin.Approved, Investigational
ClarithromycinThe serum concentration of Medrysone can be increased when it is combined with Clarithromycin.Approved
ClonixinThe risk or severity of adverse effects can be increased when Clonixin is combined with Medrysone.Approved
CobicistatThe serum concentration of Medrysone can be increased when it is combined with Cobicistat.Approved
ColesevelamColesevelam can cause a decrease in the absorption of Medrysone resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
ColestipolColestipol can cause a decrease in the absorption of Medrysone resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Conjugated Equine EstrogensThe serum concentration of Medrysone can be increased when it is combined with Conjugated Equine Estrogens.Approved
Corticorelin ovine triflutateThe therapeutic efficacy of Corticorelin ovine triflutate can be decreased when used in combination with Medrysone.Approved
CoumaphosThe risk or severity of adverse effects can be increased when Medrysone is combined with Coumaphos.Vet Approved
CurcuminThe risk or severity of adverse effects can be increased when Curcumin is combined with Medrysone.Investigational
D-LimoneneThe risk or severity of adverse effects can be increased when D-Limonene is combined with Medrysone.Investigational
DarunavirThe serum concentration of Medrysone can be increased when it is combined with Darunavir.Approved
DecamethoniumThe risk or severity of adverse effects can be increased when Medrysone is combined with Decamethonium.Approved
DeferasiroxThe risk or severity of adverse effects can be increased when Medrysone is combined with Deferasirox.Approved, Investigational
DemecariumThe risk or severity of adverse effects can be increased when Medrysone is combined with Demecarium.Approved
dersalazineThe risk or severity of adverse effects can be increased when dersalazine is combined with Medrysone.Investigational
DichlorvosThe risk or severity of adverse effects can be increased when Medrysone is combined with Dichlorvos.Vet Approved
DiclofenacThe risk or severity of adverse effects can be increased when Diclofenac is combined with Medrysone.Approved, Vet Approved
DienestrolThe serum concentration of Medrysone can be increased when it is combined with Dienestrol.Approved
DiethylstilbestrolThe serum concentration of Medrysone can be increased when it is combined with Diethylstilbestrol.Approved
DiflunisalThe risk or severity of adverse effects can be increased when Diflunisal is combined with Medrysone.Approved
DihydrotestosteroneMedrysone may increase the fluid retaining activities of Dihydrotestosterone.Illicit
DonepezilThe risk or severity of adverse effects can be increased when Medrysone is combined with Donepezil.Approved
DroxicamThe risk or severity of adverse effects can be increased when Droxicam is combined with Medrysone.Approved
DuvelisibThe risk or severity of adverse effects can be increased when Duvelisib is combined with Medrysone.Investigational
E6201The risk or severity of adverse effects can be increased when E6201 is combined with Medrysone.Investigational
EbselenThe risk or severity of adverse effects can be increased when Ebselen is combined with Medrysone.Investigational
EchothiophateThe risk or severity of adverse effects can be increased when Medrysone is combined with Echothiophate.Approved
EdrophoniumThe risk or severity of adverse effects can be increased when Medrysone is combined with Edrophonium.Approved
EnoxacinThe risk or severity of adverse effects can be increased when Medrysone is combined with Enoxacin.Approved
EnzalutamideThe serum concentration of Medrysone can be decreased when it is combined with Enzalutamide.Approved
EpirizoleThe risk or severity of adverse effects can be increased when Epirizole is combined with Medrysone.Approved
EstradiolThe serum concentration of Medrysone can be increased when it is combined with Estradiol.Approved, Investigational, Vet Approved
EstriolThe serum concentration of Medrysone can be increased when it is combined with Estriol.Approved, Vet Approved
EstroneThe serum concentration of Medrysone can be increased when it is combined with Estrone.Approved
Etacrynic acidMedrysone may increase the hypokalemic activities of Etacrynic acid.Approved
EtanerceptThe risk or severity of adverse effects can be increased when Etanercept is combined with Medrysone.Approved, Investigational
Ethinyl EstradiolThe serum concentration of Medrysone can be increased when it is combined with Ethinyl Estradiol.Approved
EtodolacThe risk or severity of adverse effects can be increased when Etodolac is combined with Medrysone.Approved, Investigational, Vet Approved
EtofenamateThe risk or severity of adverse effects can be increased when Etofenamate is combined with Medrysone.Approved
EtoricoxibThe risk or severity of adverse effects can be increased when Etoricoxib is combined with Medrysone.Approved, Investigational
Evening primrose oilThe risk or severity of adverse effects can be increased when Evening primrose oil is combined with Medrysone.Approved
exisulindThe risk or severity of adverse effects can be increased when exisulind is combined with Medrysone.Investigational
FenbufenThe risk or severity of adverse effects can be increased when Fenbufen is combined with Medrysone.Approved
FenoprofenThe risk or severity of adverse effects can be increased when Fenoprofen is combined with Medrysone.Approved
FenthionThe risk or severity of adverse effects can be increased when Medrysone is combined with Fenthion.Vet Approved
FleroxacinThe risk or severity of adverse effects can be increased when Medrysone is combined with Fleroxacin.Approved
FloctafenineThe risk or severity of adverse effects can be increased when Floctafenine is combined with Medrysone.Approved, Withdrawn
FlumequineThe risk or severity of adverse effects can be increased when Medrysone is combined with Flumequine.Withdrawn
FlunixinThe risk or severity of adverse effects can be increased when Flunixin is combined with Medrysone.Vet Approved
FluoxymesteroneMedrysone may increase the fluid retaining activities of Fluoxymesterone.Approved, Illicit
FlurbiprofenThe risk or severity of adverse effects can be increased when Flurbiprofen is combined with Medrysone.Approved, Investigational
FosaprepitantThe serum concentration of Medrysone can be increased when it is combined with Fosaprepitant.Approved
FosphenytoinThe serum concentration of Medrysone can be decreased when it is combined with Fosphenytoin.Approved
FurosemideMedrysone may increase the hypokalemic activities of Furosemide.Approved, Vet Approved
G17DTThe risk or severity of adverse effects can be increased when Medrysone is combined with G17DT.Investigational
GalantamineThe risk or severity of adverse effects can be increased when Medrysone is combined with Galantamine.Approved
Gallamine TriethiodideThe risk or severity of adverse effects can be increased when Medrysone is combined with Gallamine Triethiodide.Approved
GarenoxacinThe risk or severity of adverse effects can be increased when Medrysone is combined with Garenoxacin.Investigational
GatifloxacinThe risk or severity of adverse effects can be increased when Medrysone is combined with Gatifloxacin.Approved, Investigational
GemifloxacinThe risk or severity of adverse effects can be increased when Medrysone is combined with Gemifloxacin.Approved, Investigational
GenisteinThe serum concentration of Medrysone can be increased when it is combined with Genistein.Investigational
GI-5005The risk or severity of adverse effects can be increased when Medrysone is combined with GI-5005.Investigational
Ginkgo bilobaThe risk or severity of adverse effects can be increased when Medrysone is combined with Ginkgo biloba.Approved, Nutraceutical
Glycerol PhenylbutyrateThe therapeutic efficacy of Glycerol Phenylbutyrate can be decreased when used in combination with Medrysone.Approved
GrepafloxacinThe risk or severity of adverse effects can be increased when Medrysone is combined with Grepafloxacin.Withdrawn
HexestrolThe serum concentration of Medrysone can be increased when it is combined with Hexestrol.Withdrawn
HigenamineThe risk or severity of adverse effects can be increased when Higenamine is combined with Medrysone.Investigational
HMPL-004The risk or severity of adverse effects can be increased when HMPL-004 is combined with Medrysone.Investigational
Huperzine AThe risk or severity of adverse effects can be increased when Medrysone is combined with Huperzine A.Investigational
HyaluronidaseThe therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Medrysone.Approved, Investigational
HydrochlorothiazideMedrysone may increase the hypokalemic activities of Hydrochlorothiazide.Approved, Vet Approved
HydroflumethiazideMedrysone may increase the hypokalemic activities of Hydroflumethiazide.Approved
IbuprofenThe risk or severity of adverse effects can be increased when Ibuprofen is combined with Medrysone.Approved
IbuproxamThe risk or severity of adverse effects can be increased when Ibuproxam is combined with Medrysone.Withdrawn
IcatibantThe risk or severity of adverse effects can be increased when Icatibant is combined with Medrysone.Approved
IdelalisibThe serum concentration of Medrysone can be increased when it is combined with Idelalisib.Approved
IndacaterolIndacaterol may increase the hypokalemic activities of Medrysone.Approved
IndapamideMedrysone may increase the hypokalemic activities of Indapamide.Approved
IndinavirThe serum concentration of Medrysone can be increased when it is combined with Indinavir.Approved
IndomethacinThe risk or severity of adverse effects can be increased when Indomethacin is combined with Medrysone.Approved, Investigational
IndoprofenThe risk or severity of adverse effects can be increased when Indoprofen is combined with Medrysone.Withdrawn
INGN 201The risk or severity of adverse effects can be increased when Medrysone is combined with INGN 201.Investigational
INGN 225The risk or severity of adverse effects can be increased when Medrysone is combined with INGN 225.Investigational
IsoflurophateThe risk or severity of adverse effects can be increased when Medrysone is combined with Isoflurophate.Approved, Withdrawn
IsoniazidThe serum concentration of Isoniazid can be decreased when it is combined with Medrysone.Approved
IsoxicamThe risk or severity of adverse effects can be increased when Isoxicam is combined with Medrysone.Withdrawn
ItraconazoleThe serum concentration of Medrysone can be increased when it is combined with Itraconazole.Approved, Investigational
KebuzoneThe risk or severity of adverse effects can be increased when Kebuzone is combined with Medrysone.Experimental
KetoconazoleThe serum concentration of Medrysone can be increased when it is combined with Ketoconazole.Approved, Investigational
KetoprofenThe risk or severity of adverse effects can be increased when Ketoprofen is combined with Medrysone.Approved, Vet Approved
KetorolacThe risk or severity of adverse effects can be increased when Ketorolac is combined with Medrysone.Approved
LeflunomideThe risk or severity of adverse effects can be increased when Leflunomide is combined with Medrysone.Approved, Investigational
LevofloxacinThe risk or severity of adverse effects can be increased when Medrysone is combined with Levofloxacin.Approved, Investigational
LisofyllineThe risk or severity of adverse effects can be increased when Lisofylline is combined with Medrysone.Investigational
LomefloxacinThe risk or severity of adverse effects can be increased when Medrysone is combined with Lomefloxacin.Approved
LopinavirThe serum concentration of Medrysone can be increased when it is combined with Lopinavir.Approved
LornoxicamThe risk or severity of adverse effects can be increased when Lornoxicam is combined with Medrysone.Approved
LoxoprofenThe risk or severity of adverse effects can be increased when Loxoprofen is combined with Medrysone.Approved
LumacaftorThe serum concentration of Medrysone can be decreased when it is combined with Lumacaftor.Approved
LumiracoxibThe risk or severity of adverse effects can be increased when Lumiracoxib is combined with Medrysone.Approved, Investigational
MagaldrateThe bioavailability of Medrysone can be decreased when combined with Magaldrate.Withdrawn
Magnesium carbonateThe bioavailability of Medrysone can be decreased when combined with Magnesium carbonate.Approved
Magnesium hydroxideThe bioavailability of Medrysone can be decreased when combined with Magnesium hydroxide.Approved
Magnesium oxideThe bioavailability of Medrysone can be decreased when combined with Magnesium oxide.Approved
Magnesium salicylateThe risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Medrysone.Approved
Magnesium TrisilicateThe bioavailability of Medrysone can be decreased when combined with Magnesium Trisilicate.Approved
MalathionThe risk or severity of adverse effects can be increased when Medrysone is combined with Malathion.Approved, Investigational
MasoprocolThe risk or severity of adverse effects can be increased when Masoprocol is combined with Medrysone.Approved
Meclofenamic acidThe risk or severity of adverse effects can be increased when Meclofenamic acid is combined with Medrysone.Approved, Vet Approved
Mefenamic acidThe risk or severity of adverse effects can be increased when Mefenamic acid is combined with Medrysone.Approved
MefloquineThe risk or severity of adverse effects can be increased when Medrysone is combined with Mefloquine.Approved
MeloxicamThe risk or severity of adverse effects can be increased when Meloxicam is combined with Medrysone.Approved, Vet Approved
MemantineThe risk or severity of adverse effects can be increased when Medrysone is combined with Memantine.Approved, Investigational
MesalazineThe risk or severity of adverse effects can be increased when Mesalazine is combined with Medrysone.Approved
MestranolThe serum concentration of Medrysone can be increased when it is combined with Mestranol.Approved
MetamizoleThe risk or severity of adverse effects can be increased when Metamizole is combined with Medrysone.Withdrawn
MethallenestrilThe serum concentration of Medrysone can be increased when it is combined with Methallenestril.Experimental
Methanesulfonyl FluorideThe risk or severity of adverse effects can be increased when Medrysone is combined with Methanesulfonyl Fluoride.Investigational
MethyclothiazideMedrysone may increase the hypokalemic activities of Methyclothiazide.Approved
MethyltestosteroneMedrysone may increase the fluid retaining activities of Methyltestosterone.Approved
MetolazoneMedrysone may increase the hypokalemic activities of Metolazone.Approved
MifepristoneThe therapeutic efficacy of Medrysone can be decreased when used in combination with Mifepristone.Approved, Investigational
MinaprineThe risk or severity of adverse effects can be increased when Medrysone is combined with Minaprine.Approved
MitotaneThe serum concentration of Medrysone can be decreased when it is combined with Mitotane.Approved
MivacuriumMivacurium may increase the adverse neuromuscular activities of Medrysone.Approved
MizoribineThe risk or severity of adverse effects can be increased when Mizoribine is combined with Medrysone.Investigational
MoxifloxacinThe risk or severity of adverse effects can be increased when Medrysone is combined with Moxifloxacin.Approved, Investigational
Mycophenolate mofetilThe risk or severity of adverse effects can be increased when Mycophenolate mofetil is combined with Medrysone.Approved, Investigational
Mycophenolic acidThe risk or severity of adverse effects can be increased when Mycophenolic acid is combined with Medrysone.Approved
NabumetoneThe risk or severity of adverse effects can be increased when Nabumetone is combined with Medrysone.Approved
NafamostatThe risk or severity of adverse effects can be increased when Nafamostat is combined with Medrysone.Investigational
NaftifineThe risk or severity of adverse effects can be increased when Naftifine is combined with Medrysone.Approved
Nalidixic AcidThe risk or severity of adverse effects can be increased when Medrysone is combined with Nalidixic Acid.Approved
NaproxenThe risk or severity of adverse effects can be increased when Naproxen is combined with Medrysone.Approved, Vet Approved
NCX 4016The risk or severity of adverse effects can be increased when NCX 4016 is combined with Medrysone.Investigational
NefazodoneThe serum concentration of Medrysone can be increased when it is combined with Nefazodone.Approved, Withdrawn
NelfinavirThe serum concentration of Medrysone can be increased when it is combined with Nelfinavir.Approved
NemonoxacinThe risk or severity of adverse effects can be increased when Medrysone is combined with Nemonoxacin.Investigational
NeostigmineThe risk or severity of adverse effects can be increased when Medrysone is combined with Neostigmine.Approved, Vet Approved
NepafenacThe risk or severity of adverse effects can be increased when Nepafenac is combined with Medrysone.Approved
NevirapineThe serum concentration of Medrysone can be decreased when it is combined with Nevirapine.Approved
NicorandilThe risk or severity of adverse effects can be increased when Medrysone is combined with Nicorandil.Approved
Niflumic AcidThe risk or severity of adverse effects can be increased when Niflumic Acid is combined with Medrysone.Approved
NimesulideThe risk or severity of adverse effects can be increased when Nimesulide is combined with Medrysone.Approved, Withdrawn
NitroaspirinThe risk or severity of adverse effects can be increased when Nitroaspirin is combined with Medrysone.Investigational
NorfloxacinThe risk or severity of adverse effects can be increased when Medrysone is combined with Norfloxacin.Approved
OfloxacinThe risk or severity of adverse effects can be increased when Medrysone is combined with Ofloxacin.Approved
OlopatadineThe risk or severity of adverse effects can be increased when Olopatadine is combined with Medrysone.Approved
OlsalazineThe risk or severity of adverse effects can be increased when Olsalazine is combined with Medrysone.Approved
OrgoteinThe risk or severity of adverse effects can be increased when Orgotein is combined with Medrysone.Vet Approved
OxandroloneMedrysone may increase the fluid retaining activities of Oxandrolone.Approved, Investigational
OxaprozinThe risk or severity of adverse effects can be increased when Oxaprozin is combined with Medrysone.Approved
OxymetholoneMedrysone may increase the fluid retaining activities of Oxymetholone.Approved, Illicit
OxyphenbutazoneThe risk or severity of adverse effects can be increased when Oxyphenbutazone is combined with Medrysone.Withdrawn
ParecoxibThe risk or severity of adverse effects can be increased when Parecoxib is combined with Medrysone.Approved
PazufloxacinThe risk or severity of adverse effects can be increased when Medrysone is combined with Pazufloxacin.Investigational
PefloxacinThe risk or severity of adverse effects can be increased when Medrysone is combined with Pefloxacin.Approved
PentobarbitalThe serum concentration of Medrysone can be decreased when it is combined with Pentobarbital.Approved, Vet Approved
PhenobarbitalThe serum concentration of Medrysone can be decreased when it is combined with Phenobarbital.Approved
Phenylacetic acidThe therapeutic efficacy of Phenylacetic acid can be decreased when used in combination with Medrysone.Approved
PhenylbutazoneThe risk or severity of adverse effects can be increased when Phenylbutazone is combined with Medrysone.Approved, Vet Approved
PhenytoinThe serum concentration of Medrysone can be decreased when it is combined with Phenytoin.Approved, Vet Approved
PhysostigmineThe risk or severity of adverse effects can be increased when Medrysone is combined with Physostigmine.Approved
PimecrolimusThe risk or severity of adverse effects can be increased when Pimecrolimus is combined with Medrysone.Approved, Investigational
PiretanideMedrysone may increase the hypokalemic activities of Piretanide.Experimental
PirfenidoneThe risk or severity of adverse effects can be increased when Pirfenidone is combined with Medrysone.Investigational
PiroxicamThe risk or severity of adverse effects can be increased when Piroxicam is combined with Medrysone.Approved, Investigational
Polyestradiol phosphateThe serum concentration of Medrysone can be increased when it is combined with Polyestradiol phosphate.Approved
PolythiazideMedrysone may increase the hypokalemic activities of Polythiazide.Approved
PosaconazoleThe serum concentration of Medrysone can be increased when it is combined with Posaconazole.Approved, Investigational, Vet Approved
PrimidoneThe serum concentration of Medrysone can be decreased when it is combined with Primidone.Approved, Vet Approved
PromestrieneThe serum concentration of Medrysone can be increased when it is combined with Promestriene.Investigational
PropacetamolThe risk or severity of adverse effects can be increased when Propacetamol is combined with Medrysone.Approved
PrulifloxacinThe risk or severity of adverse effects can be increased when Medrysone is combined with Prulifloxacin.Investigational
PTC299The risk or severity of adverse effects can be increased when PTC299 is combined with Medrysone.Investigational
PyridostigmineThe risk or severity of adverse effects can be increased when Medrysone is combined with Pyridostigmine.Approved
QuinestrolThe serum concentration of Medrysone can be increased when it is combined with Quinestrol.Approved
QuinethazoneMedrysone may increase the hypokalemic activities of Quinethazone.Approved
Rabies vaccineThe risk or severity of adverse effects can be increased when Medrysone is combined with Rabies vaccine.Approved
RapacuroniumRapacuronium may increase the adverse neuromuscular activities of Medrysone.Withdrawn
ResveratrolThe risk or severity of adverse effects can be increased when Resveratrol is combined with Medrysone.Experimental, Investigational
RifabutinThe serum concentration of Medrysone can be decreased when it is combined with Rifabutin.Approved
RifampicinThe serum concentration of Medrysone can be decreased when it is combined with Rifampicin.Approved
RifapentineThe serum concentration of Medrysone can be decreased when it is combined with Rifapentine.Approved
RitonavirThe serum concentration of Medrysone can be increased when it is combined with Ritonavir.Approved, Investigational
RivastigmineThe risk or severity of adverse effects can be increased when Medrysone is combined with Rivastigmine.Approved, Investigational
RofecoxibThe risk or severity of adverse effects can be increased when Rofecoxib is combined with Medrysone.Investigational, Withdrawn
RosoxacinThe risk or severity of adverse effects can be increased when Medrysone is combined with Rosoxacin.Approved
S EquolThe serum concentration of Medrysone can be increased when it is combined with S Equol.Investigational
SalicylamideThe risk or severity of adverse effects can be increased when Salicylamide is combined with Medrysone.Approved
Salicylic acidThe risk or severity of adverse effects can be increased when Salicylic acid is combined with Medrysone.Approved, Vet Approved
SalsalateThe risk or severity of adverse effects can be increased when Salsalate is combined with Medrysone.Approved
SaquinavirThe serum concentration of Medrysone can be increased when it is combined with Saquinavir.Approved, Investigational
SecoisolariciresinolThe serum concentration of Medrysone can be increased when it is combined with Secoisolariciresinol.Investigational
SeratrodastThe risk or severity of adverse effects can be increased when Seratrodast is combined with Medrysone.Approved, Investigational
Sodium phenylbutyrateThe therapeutic efficacy of Sodium phenylbutyrate can be decreased when used in combination with Medrysone.Approved
SparfloxacinThe risk or severity of adverse effects can be increased when Medrysone is combined with Sparfloxacin.Approved
SRP 299The risk or severity of adverse effects can be increased when Medrysone is combined with SRP 299.Investigational
SRT501The risk or severity of adverse effects can be increased when SRT501 is combined with Medrysone.Investigational
St. John's WortThe serum concentration of Medrysone can be decreased when it is combined with St. John's Wort.Nutraceutical
StanozololMedrysone may increase the fluid retaining activities of Stanozolol.Approved, Vet Approved
SulfasalazineThe risk or severity of adverse effects can be increased when Sulfasalazine is combined with Medrysone.Approved
SulindacThe risk or severity of adverse effects can be increased when Sulindac is combined with Medrysone.Approved
SuprofenThe risk or severity of adverse effects can be increased when Suprofen is combined with Medrysone.Approved, Withdrawn
Synthetic Conjugated Estrogens, AThe serum concentration of Medrysone can be increased when it is combined with Synthetic Conjugated Estrogens, A.Approved
Synthetic Conjugated Estrogens, BThe serum concentration of Medrysone can be increased when it is combined with Synthetic Conjugated Estrogens, B.Approved
TacrineThe risk or severity of adverse effects can be increased when Medrysone is combined with Tacrine.Withdrawn
TelaprevirThe serum concentration of Telaprevir can be decreased when it is combined with Medrysone.Approved
TelithromycinThe serum concentration of Medrysone can be increased when it is combined with Telithromycin.Approved
TemafloxacinThe risk or severity of adverse effects can be increased when Medrysone is combined with Temafloxacin.Withdrawn
TenoxicamThe risk or severity of adverse effects can be increased when Tenoxicam is combined with Medrysone.Approved
TepoxalinThe risk or severity of adverse effects can be increased when Tepoxalin is combined with Medrysone.Vet Approved
TeriflunomideThe risk or severity of adverse effects can be increased when Teriflunomide is combined with Medrysone.Approved
TestosteroneMedrysone may increase the fluid retaining activities of Testosterone.Approved, Investigational
TG4010The risk or severity of adverse effects can be increased when Medrysone is combined with TG4010.Investigational
Tiaprofenic acidThe risk or severity of adverse effects can be increased when Tiaprofenic acid is combined with Medrysone.Approved
TiboloneThe serum concentration of Medrysone can be increased when it is combined with Tibolone.Approved
TinoridineThe risk or severity of adverse effects can be increased when Tinoridine is combined with Medrysone.Investigational
Tolfenamic AcidThe risk or severity of adverse effects can be increased when Tolfenamic Acid is combined with Medrysone.Approved
TolmetinThe risk or severity of adverse effects can be increased when Tolmetin is combined with Medrysone.Approved
TorasemideMedrysone may increase the hypokalemic activities of Torasemide.Approved
TranilastThe risk or severity of adverse effects can be increased when Tranilast is combined with Medrysone.Approved, Investigational
TrichlorfonThe risk or severity of adverse effects can be increased when Medrysone is combined with Trichlorfon.Vet Approved
TrichlormethiazideMedrysone may increase the hypokalemic activities of Trichlormethiazide.Approved, Vet Approved
Trisalicylate-cholineThe risk or severity of adverse effects can be increased when Trisalicylate-choline is combined with Medrysone.Approved
TrovafloxacinThe risk or severity of adverse effects can be increased when Medrysone is combined with Trovafloxacin.Approved, Withdrawn
TubocurarineThe risk or severity of adverse effects can be increased when Medrysone is combined with Tubocurarine.Approved
ValdecoxibThe risk or severity of adverse effects can be increased when Valdecoxib is combined with Medrysone.Investigational, Withdrawn
VoriconazoleThe serum concentration of Medrysone can be increased when it is combined with Voriconazole.Approved, Investigational
WarfarinMedrysone may increase the anticoagulant activities of Warfarin.Approved
ZaltoprofenThe risk or severity of adverse effects can be increased when Zaltoprofen is combined with Medrysone.Approved
ZeranolThe serum concentration of Medrysone can be increased when it is combined with Zeranol.Vet Approved
ZileutonThe risk or severity of adverse effects can be increased when Zileuton is combined with Medrysone.Approved, Investigational, Withdrawn
ZomepiracThe risk or severity of adverse effects can be increased when Zomepirac is combined with Medrysone.Withdrawn
Food InteractionsNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesS01BA08
AHFS Codes
  • 52:08.08
PDB EntriesNot Available
FDA labelDownload (149 KB)
MSDSDownload (48.5 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.9705
Caco-2 permeable+0.8125
P-glycoprotein substrateSubstrate0.6825
P-glycoprotein inhibitor IInhibitor0.6076
P-glycoprotein inhibitor IINon-inhibitor0.7298
Renal organic cation transporterNon-inhibitor0.7757
CYP450 2C9 substrateNon-substrate0.7961
CYP450 2D6 substrateNon-substrate0.9127
CYP450 3A4 substrateSubstrate0.7688
CYP450 1A2 substrateNon-inhibitor0.9046
CYP450 2C9 inhibitorNon-inhibitor0.869
CYP450 2D6 inhibitorNon-inhibitor0.9491
CYP450 2C19 inhibitorNon-inhibitor0.9026
CYP450 3A4 inhibitorNon-inhibitor0.8309
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9052
Ames testNon AMES toxic0.9525
CarcinogenicityNon-carcinogens0.9338
BiodegradationNot ready biodegradable0.9822
Rat acute toxicity2.3015 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8934
hERG inhibition (predictor II)Non-inhibitor0.7724
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Allergan pharmaceutical
PackagersNot Available
Dosage forms
FormRouteStrength
Solution / dropsOphthalmic1 %
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point156.5 °CPhysProp
logP3.2Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0337 mg/mLALOGPS
logP3.06ALOGPS
logP3.13ChemAxon
logS-4ALOGPS
pKa (Strongest Acidic)19.14ChemAxon
pKa (Strongest Basic)-0.26ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area54.37 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity98.85 m3·mol-1ChemAxon
Polarizability39.92 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as gluco/mineralocorticoids, progestogins and derivatives. These are steroids with a structure based on a hydroxylated prostane moiety.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
Sub ClassPregnane steroids
Direct ParentGluco/mineralocorticoids, progestogins and derivatives
Alternative Parents
Substituents
  • Progestogin-skeleton
  • 20-oxosteroid
  • 11-hydroxysteroid
  • 11-beta-hydroxysteroid
  • Oxosteroid
  • Hydroxysteroid
  • 3-oxosteroid
  • 3-oxo-delta-4-steroid
  • Delta-4-steroid
  • Cyclic alcohol
  • Cyclic ketone
  • Secondary alcohol
  • Ketone
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Alcohol
  • Aliphatic homopolycyclic compound
Molecular FrameworkAliphatic homopolycyclic compounds
External DescriptorsNot Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Zinc ion binding
Specific Function:
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon grow...
Gene Name:
NR3C1
Uniprot ID:
P04150
Molecular Weight:
85658.57 Da
References
  1. Southren AL, Dominguez MO, Gordon GG, Wenk EJ, Hernandez MR, Dunn MW, Weinstein BI: Nuclear translocation of the cytoplasmic glucocorticoid receptor in the iris-ciliary body and adjacent corneoscleral tissue of the rabbit following topical administration of various glucocorticoids. A rapid screening method for glucocorticoid activity. Invest Ophthalmol Vis Sci. 1983 Feb;24(2):147-52. [PubMed:6336597 ]
  2. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Steroid binding
Specific Function:
Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species.
Gene Name:
SERPINA6
Uniprot ID:
P08185
Molecular Weight:
45140.49 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
Comments
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23