Identification

Name
Nitroprusside
Accession Number
DB00325  (APRD01143)
Type
Small Molecule
Groups
Approved
Description

Nitroprusside serves as a source of nitric oxide, a potent peripheral vasodilator that affects both arterioles and venules (venules more than arterioles). Nitroprusside is often administered intravenously to patients who are experiencing a hypertensive emergency. [Wikipedia]

Structure
Thumb
Synonyms
  • [Fe(CN)5(NO)](2-)
  • Nitroferricyanide
Product Ingredients
IngredientUNIICASInChI Key
Sodium nitroprussideEAO03PE1TC13755-38-9SPBWMYPZWNFWES-UHFFFAOYSA-N
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
NipridePowder, for solution50 mgIntravenousHospira, Inc.1975-12-312011-08-05Canada
NiprideSolution25 mgIntravenousPfizer2011-05-17Not applicableCanada
Nipride RtuInjection, solution.5 mg/mLIntravenousExela Pharma Sciences, Llc.2017-03-20Not applicableUs
Sodium Nitroprusside for InjectionSolution25 mgIntravenousSterimax IncNot applicableNot applicableCanada
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
NitropressInjection, solution, concentrate50 mg/2mLIntravenousHospira, Inc.1988-08-012017-06-24Us
NitropressInjection, solution, concentrate50 mg/2mLIntravenousMarathon Pharmaceuticals2013-12-012016-05-31Us
NitropressInjection, solution, concentrate50 mg/2mLIntravenousValeant Pharmaceuticals North America2013-12-01Not applicableUs
Sodium NitroprussideInjection25 mg/mLIntravenousNexus Pharmaceuticals Inc2017-05-29Not applicableUs
Sodium NitroprussideInjection, solution, concentrate25 mg/mLIntravenousSagent Pharmaceuticals2016-10-06Not applicableUs
Sodium NitroprussideInjection50 mg/2mLIntravenousMicro Labs Limited2017-12-30Not applicableUs
Sodium NitroprussideInjection, solution, concentrate50 mg/2mLIntravenousAkorn2017-05-04Not applicableUs
Sodium NitroprussideInjection50 mg/2mLIntravenousAmphastar Pharmaceuticals, Inc.2017-12-18Not applicableUs
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Sodium nitroprussideInjection25 mg/mLIntravenousAmneal Biosciences Llc2017-11-07Not applicableUs
Categories
UNII
169D1260KM
CAS number
15078-28-1
Weight
Average: 215.938
Monoisotopic: 215.948300785
Chemical Formula
C5FeN6O
InChI Key
ASPOIVQEUUCDQT-UHFFFAOYSA-N
InChI
InChI=1S/5CN.Fe.NO/c5*1-2;;1-2/q;;;;;2*-1
IUPAC Name
pentacyano(nitroso)irondiuide
SMILES
O=N[Fe--](C#N)(C#N)(C#N)(C#N)C#N

Pharmacology

Indication

For immediate reduction of blood pressure of patients in hypertensive crises, reduce bleeding during surgery, and for the treatment of acute congestive heart failure

Structured Indications
Pharmacodynamics

Nitroprusside a powerful vasodilator relaxes the vascular smooth muscle and produce consequent dilatation of peripheral arteries and veins. Other smooth muscle (e.g., uterus, duodenum) is not affected. Sodium nitroprusside is more active on veins than on arteries.

Mechanism of action

One molecule of sodium nitroprusside is metabolized by combination with hemoglobin to produce one molecule of cyanmethemoglobin and four CN- ions; methemoglobin, obtained from hemoglobin, can sequester cyanide as cyanmethemoglobin; thiosulfate reacts with cyanide to produce thiocyanate; thiocyanate is eliminated in the urine; cyanide not otherwise removed binds to cytochromes. Cyanide ion is normally found in serum; it is derived from dietary substrates and from tobacco smoke. Cyanide binds avidly (but reversibly) to ferric ion (Fe+++), most body stores of which are found in erythrocyte methemoglobin (metHgb) and in mitochondrial cytochromes. When CN is infused or generated within the bloodstream, essentially all of it is bound to methemoglobin until intraerythrocytic methemoglobin has been saturated. Once activated to NO, it activates guanylate cyclase in vascular smooth muscle and increases intracellular production of cGMP. cGMP stimulates calcium movement from the cytoplasm to the endoplasmic reticulum and reduces calcium available to bind with calmodulin. This eventually leads to vascular smooth muscle relaxation and vessel dilatation.

TargetActionsOrganism
AAtrial natriuretic peptide receptor 1
agonist
Human
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism

Metabolized by reaction with hemoglobin to produce cyanmethemoglobin and cynide ions

Route of elimination

One molecule of sodium nitroprusside is metabolized by combination with hemoglobin to produce one molecule of cyanmethemoglobin and four CN¯ ions, thiosulfate reacts with cyanide to produce thiocyanate, thiocyanate is eliminated in the urine.

Half life

Approximately 2 minutes

Clearance
Not Available
Toxicity

Overdosage of nitroprusside can be manifested as excessive hypotension or cyanide toxicity or as thiocyanate toxicity. The acute intravenous mean lethal doses (LD50) of nitroprusside in rabbits, dogs, mice, and rats are 2.8, 5.0, 8.4, and 11.2 mg/kg, respectively.

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline may increase the hypotensive activities of Nitroprusside.Experimental
AcebutololNitroprusside may increase the hypotensive activities of Acebutolol.Approved
AcemetacinThe therapeutic efficacy of Nitroprusside can be decreased when used in combination with Acemetacin.Approved, Experimental, Investigational
AlfuzosinAlfuzosin may increase the hypotensive activities of Nitroprusside.Approved, Investigational
AliskirenNitroprusside may increase the hypotensive activities of Aliskiren.Approved, Investigational
AlprenololNitroprusside may increase the hypotensive activities of Alprenolol.Approved, Withdrawn
AmbrisentanNitroprusside may increase the hypotensive activities of Ambrisentan.Approved, Investigational
AmifostineNitroprusside may increase the hypotensive activities of Amifostine.Approved, Investigational
AmlodipineAmlodipine may increase the hypotensive activities of Nitroprusside.Approved
AmphetamineAmphetamine may increase the hypotensive activities of Nitroprusside.Approved, Illicit
AmrinoneAmrinone may increase the hypotensive activities of Nitroprusside.Approved
AtenololNitroprusside may increase the hypotensive activities of Atenolol.Approved
AvanafilAvanafil may increase the antihypertensive activities of Nitroprusside.Approved
AzelnidipineAzelnidipine may increase the hypotensive activities of Nitroprusside.Approved, Investigational
AzimilideAzimilide may increase the hypotensive activities of Nitroprusside.Investigational
BarnidipineBarnidipine may increase the hypotensive activities of Nitroprusside.Approved
BenazeprilNitroprusside may increase the hypotensive activities of Benazepril.Approved, Investigational
BencyclaneBencyclane may increase the hypotensive activities of Nitroprusside.Experimental
BendroflumethiazideNitroprusside may increase the hypotensive activities of Bendroflumethiazide.Approved
BenidipineBenidipine may increase the hypotensive activities of Nitroprusside.Approved, Investigational
BepridilBepridil may increase the hypotensive activities of Nitroprusside.Approved, Withdrawn
BetaxololNitroprusside may increase the hypotensive activities of Betaxolol.Approved
BethanidineBethanidine may increase the hypotensive activities of Nitroprusside.Approved
BietaserpineNitroprusside may increase the hypotensive activities of Bietaserpine.Experimental
BimatoprostNitroprusside may increase the hypotensive activities of Bimatoprost.Approved, Investigational
BisoprololNitroprusside may increase the hypotensive activities of Bisoprolol.Approved
BosentanNitroprusside may increase the hypotensive activities of Bosentan.Approved, Investigational
BQ-123Nitroprusside may increase the hypotensive activities of BQ-123.Investigational
BretyliumNitroprusside may increase the hypotensive activities of Bretylium.Approved
BrimonidineBrimonidine may increase the antihypertensive activities of Nitroprusside.Approved
BrofaromineBrofaromine may increase the hypotensive activities of Nitroprusside.Experimental
BupranololNitroprusside may increase the hypotensive activities of Bupranolol.Approved
CadralazineNitroprusside may increase the hypotensive activities of Cadralazine.Experimental
CafedrineNitroprusside may increase the hypotensive activities of Cafedrine.Investigational
CandesartanNitroprusside may increase the hypotensive activities of Candesartan.Experimental
Candesartan cilexetilNitroprusside may increase the hypotensive activities of Candesartan cilexetil.Approved
CandoxatrilNitroprusside may increase the hypotensive activities of Candoxatril.Experimental
CaptoprilNitroprusside may increase the hypotensive activities of Captopril.Approved
CarboxyamidotriazoleCarboxyamidotriazole may increase the hypotensive activities of Nitroprusside.Investigational
CaroverineCaroverine may increase the hypotensive activities of Nitroprusside.Experimental
CarteololNitroprusside may increase the hypotensive activities of Carteolol.Approved
CarvedilolNitroprusside may increase the hypotensive activities of Carvedilol.Approved, Investigational
CeliprololNitroprusside may increase the hypotensive activities of Celiprolol.Approved, Investigational
ChlorothiazideNitroprusside may increase the hypotensive activities of Chlorothiazide.Approved, Vet Approved
ChlorthalidoneNitroprusside may increase the hypotensive activities of Chlorthalidone.Approved
CicletanineNitroprusside may increase the hypotensive activities of Cicletanine.Investigational
CilazaprilNitroprusside may increase the hypotensive activities of Cilazapril.Approved
CilnidipineCilnidipine may increase the hypotensive activities of Nitroprusside.Approved, Investigational
CinnarizineCinnarizine may increase the hypotensive activities of Nitroprusside.Approved, Investigational
ClevidipineClevidipine may increase the hypotensive activities of Nitroprusside.Approved
ClonidineNitroprusside may increase the hypotensive activities of Clonidine.Approved
CloranololNitroprusside may increase the hypotensive activities of Cloranolol.Experimental
CryptenamineNitroprusside may increase the hypotensive activities of Cryptenamine.Approved
CyclopenthiazideNitroprusside may increase the hypotensive activities of Cyclopenthiazide.Experimental
CyclothiazideNitroprusside may increase the hypotensive activities of Cyclothiazide.Approved
DarodipineDarodipine may increase the hypotensive activities of Nitroprusside.Experimental
DebrisoquinNitroprusside may increase the hypotensive activities of Debrisoquin.Approved, Investigational
DelaprilNitroprusside may increase the hypotensive activities of Delapril.Experimental
DeserpidineNitroprusside may increase the hypotensive activities of Deserpidine.Approved
DiazoxideDiazoxide may increase the hypotensive activities of Nitroprusside.Approved
DiethylnorspermineNitroprusside may increase the hypotensive activities of Diethylnorspermine.Investigational
DihydralazineNitroprusside may increase the hypotensive activities of Dihydralazine.Investigational
DiltiazemDiltiazem may increase the hypotensive activities of Nitroprusside.Approved
DorzolamideNitroprusside may increase the hypotensive activities of Dorzolamide.Approved
DotarizineDotarizine may increase the hypotensive activities of Nitroprusside.Investigational
DoxazosinNitroprusside may increase the hypotensive activities of Doxazosin.Approved
EfonidipineEfonidipine may increase the hypotensive activities of Nitroprusside.Approved, Investigational
EnalaprilNitroprusside may increase the hypotensive activities of Enalapril.Approved, Vet Approved
EnalaprilatNitroprusside may increase the hypotensive activities of Enalaprilat.Approved
EndralazineNitroprusside may increase the hypotensive activities of Endralazine.Experimental
EpanololNitroprusside may increase the hypotensive activities of Epanolol.Experimental
EperisoneEperisone may increase the hypotensive activities of Nitroprusside.Approved, Investigational
EpoprostenolNitroprusside may increase the hypotensive activities of Epoprostenol.Approved
EprosartanNitroprusside may increase the hypotensive activities of Eprosartan.Approved
FelodipineFelodipine may increase the hypotensive activities of Nitroprusside.Approved, Investigational
FendilineFendiline may increase the hypotensive activities of Nitroprusside.Withdrawn
FenoldopamNitroprusside may increase the hypotensive activities of Fenoldopam.Approved
Ferulic acidNitroprusside may increase the hypotensive activities of Ferulic acid.Experimental
FlunarizineFlunarizine may increase the hypotensive activities of Nitroprusside.Approved
FosinoprilNitroprusside may increase the hypotensive activities of Fosinopril.Approved
FurazolidoneFurazolidone may increase the hypotensive activities of Nitroprusside.Approved, Investigational, Vet Approved
GabapentinGabapentin may increase the hypotensive activities of Nitroprusside.Approved, Investigational
GallopamilGallopamil may increase the hypotensive activities of Nitroprusside.Investigational
GuanabenzNitroprusside may increase the hypotensive activities of Guanabenz.Approved, Investigational
GuanadrelNitroprusside may increase the hypotensive activities of Guanadrel.Approved
GuanazodineNitroprusside may increase the hypotensive activities of Guanazodine.Experimental
GuanethidineNitroprusside may increase the hypotensive activities of Guanethidine.Approved
GuanfacineNitroprusside may increase the hypotensive activities of Guanfacine.Approved, Investigational
GuanoclorNitroprusside may increase the hypotensive activities of Guanoclor.Experimental
GuanoxabenzNitroprusside may increase the hypotensive activities of Guanoxabenz.Experimental
GuanoxanNitroprusside may increase the hypotensive activities of Guanoxan.Experimental
HarmalineHarmaline may increase the hypotensive activities of Nitroprusside.Experimental
HexamethoniumNitroprusside may increase the hypotensive activities of Hexamethonium.Experimental
HydralazineNitroprusside may increase the hypotensive activities of Hydralazine.Approved
HydrochlorothiazideNitroprusside may increase the hypotensive activities of Hydrochlorothiazide.Approved, Vet Approved
HydroflumethiazideNitroprusside may increase the hypotensive activities of Hydroflumethiazide.Approved, Investigational
ImidaprilNitroprusside may increase the hypotensive activities of Imidapril.Investigational
IndapamideNitroprusside may increase the hypotensive activities of Indapamide.Approved
IndenololNitroprusside may increase the hypotensive activities of Indenolol.Withdrawn
IndoraminNitroprusside may increase the hypotensive activities of Indoramin.Withdrawn
IproniazidIproniazid may increase the hypotensive activities of Nitroprusside.Withdrawn
IrbesartanNitroprusside may increase the hypotensive activities of Irbesartan.Approved, Investigational
IsocarboxazidIsocarboxazid may increase the hypotensive activities of Nitroprusside.Approved
IsradipineIsradipine may increase the hypotensive activities of Nitroprusside.Approved
KetanserinNitroprusside may increase the hypotensive activities of Ketanserin.Investigational
LabetalolNitroprusside may increase the hypotensive activities of Labetalol.Approved
LacidipineLacidipine may increase the hypotensive activities of Nitroprusside.Approved, Investigational
LamotrigineLamotrigine may increase the hypotensive activities of Nitroprusside.Approved, Investigational
LatanoprostNitroprusside may increase the hypotensive activities of Latanoprost.Approved, Investigational
LercanidipineLercanidipine may increase the hypotensive activities of Nitroprusside.Approved, Investigational
LidoflazineLidoflazine may increase the hypotensive activities of Nitroprusside.Experimental
LinsidomineNitroprusside may increase the hypotensive activities of Linsidomine.Experimental
LisinoprilNitroprusside may increase the hypotensive activities of Lisinopril.Approved, Investigational
LofexidineNitroprusside may increase the hypotensive activities of Lofexidine.Approved, Investigational
LosartanNitroprusside may increase the hypotensive activities of Losartan.Approved
MacitentanNitroprusside may increase the hypotensive activities of Macitentan.Approved
Magnesium SulfateMagnesium Sulfate may increase the hypotensive activities of Nitroprusside.Approved, Vet Approved
ManidipineManidipine may increase the hypotensive activities of Nitroprusside.Approved, Investigational
MecamylamineNitroprusside may increase the hypotensive activities of Mecamylamine.Approved
MethoserpidineNitroprusside may increase the hypotensive activities of Methoserpidine.Experimental
MethyldopaNitroprusside may increase the hypotensive activities of Methyldopa.Approved
MethylphenidateMethylphenidate may decrease the antihypertensive activities of Nitroprusside.Approved, Investigational
MetipranololNitroprusside may increase the hypotensive activities of Metipranolol.Approved
MetolazoneNitroprusside may increase the hypotensive activities of Metolazone.Approved
MetoprololNitroprusside may increase the hypotensive activities of Metoprolol.Approved, Investigational
MetyrosineNitroprusside may increase the hypotensive activities of Metyrosine.Approved
MibefradilMibefradil may increase the hypotensive activities of Nitroprusside.Investigational, Withdrawn
MinaprineMinaprine may increase the hypotensive activities of Nitroprusside.Approved
MinoxidilNitroprusside may increase the hypotensive activities of Minoxidil.Approved
MirodenafilMirodenafil may increase the antihypertensive activities of Nitroprusside.Investigational
MoclobemideMoclobemide may increase the hypotensive activities of Nitroprusside.Approved
MoexiprilNitroprusside may increase the hypotensive activities of Moexipril.Approved
MolsidomineMolsidomine may increase the hypotensive activities of Nitroprusside.Approved, Investigational
MoxonidineNitroprusside may increase the hypotensive activities of Moxonidine.Approved, Investigational
MuzolimineNitroprusside may increase the hypotensive activities of Muzolimine.Experimental
NadololNitroprusside may increase the hypotensive activities of Nadolol.Approved
NaftopidilNaftopidil may increase the hypotensive activities of Nitroprusside.Investigational
NebivololNitroprusside may increase the hypotensive activities of Nebivolol.Approved, Investigational
NialamideNialamide may increase the hypotensive activities of Nitroprusside.Withdrawn
NicardipineNicardipine may increase the hypotensive activities of Nitroprusside.Approved
NicorandilNitroprusside may increase the hypotensive activities of Nicorandil.Approved, Investigational
NifedipineNifedipine may increase the hypotensive activities of Nitroprusside.Approved
NiguldipineNiguldipine may increase the hypotensive activities of Nitroprusside.Experimental
NiludipineNiludipine may increase the hypotensive activities of Nitroprusside.Experimental
NilvadipineNilvadipine may increase the hypotensive activities of Nitroprusside.Approved, Investigational
NimesulideNimesulide may increase the hypotensive activities of Nitroprusside.Approved, Investigational, Withdrawn
NimodipineNimodipine may increase the hypotensive activities of Nitroprusside.Approved
NisoldipineNisoldipine may increase the hypotensive activities of Nitroprusside.Approved
NitrendipineNitrendipine may increase the hypotensive activities of Nitroprusside.Approved, Investigational
ObinutuzumabNitroprusside may increase the hypotensive activities of Obinutuzumab.Approved
OlmesartanNitroprusside may increase the hypotensive activities of Olmesartan.Approved, Investigational
OmapatrilatNitroprusside may increase the hypotensive activities of Omapatrilat.Investigational
OtiloniumOtilonium may increase the hypotensive activities of Nitroprusside.Experimental, Investigational
OxprenololNitroprusside may increase the hypotensive activities of Oxprenolol.Approved
PargylinePargyline may increase the hypotensive activities of Nitroprusside.Approved
PenbutololNitroprusside may increase the hypotensive activities of Penbutolol.Approved, Investigational
PentoliniumNitroprusside may increase the hypotensive activities of Pentolinium.Approved
PentoxifyllinePentoxifylline may increase the hypotensive activities of Nitroprusside.Approved, Investigational
PerhexilinePerhexiline may increase the hypotensive activities of Nitroprusside.Approved, Investigational
PerindoprilNitroprusside may increase the hypotensive activities of Perindopril.Approved
PhenelzinePhenelzine may increase the hypotensive activities of Nitroprusside.Approved
PhenoxybenzamineNitroprusside may increase the hypotensive activities of Phenoxybenzamine.Approved
PhentolamineNitroprusside may increase the hypotensive activities of Phentolamine.Approved
PinacidilNitroprusside may increase the hypotensive activities of Pinacidil.Withdrawn
PinaveriumPinaverium may increase the hypotensive activities of Nitroprusside.Approved
PindololNitroprusside may increase the hypotensive activities of Pindolol.Approved
PirlindolePirlindole may increase the hypotensive activities of Nitroprusside.Approved
Platelet Activating FactorNitroprusside may increase the hypotensive activities of Platelet Activating Factor.Experimental
PolythiazideNitroprusside may increase the hypotensive activities of Polythiazide.Approved
PrazosinNitroprusside may increase the hypotensive activities of Prazosin.Approved
PregabalinPregabalin may increase the hypotensive activities of Nitroprusside.Approved, Illicit, Investigational
PrenylaminePrenylamine may increase the hypotensive activities of Nitroprusside.Withdrawn
ProcarbazineProcarbazine may increase the hypotensive activities of Nitroprusside.Approved
PropranololNitroprusside may increase the hypotensive activities of Propranolol.Approved, Investigational
QuinaprilNitroprusside may increase the hypotensive activities of Quinapril.Approved, Investigational
RamiprilNitroprusside may increase the hypotensive activities of Ramipril.Approved
RasagilineRasagiline may increase the hypotensive activities of Nitroprusside.Approved
RemikirenNitroprusside may increase the hypotensive activities of Remikiren.Approved
RescinnamineNitroprusside may increase the hypotensive activities of Rescinnamine.Approved
ReserpineReserpine may increase the hypotensive activities of Nitroprusside.Approved, Investigational
RilmenidineNitroprusside may increase the hypotensive activities of Rilmenidine.Investigational
RiociguatNitroprusside may increase the hypotensive activities of Riociguat.Approved
RisedronateRisedronate may increase the hypotensive activities of Nitroprusside.Approved, Investigational
RituximabNitroprusside may increase the hypotensive activities of Rituximab.Approved
SaprisartanNitroprusside may increase the hypotensive activities of Saprisartan.Experimental
SelegilineSelegiline may increase the hypotensive activities of Nitroprusside.Approved, Investigational, Vet Approved
SelexipagNitroprusside may increase the hypotensive activities of Selexipag.Approved
SildenafilSildenafil may increase the antihypertensive activities of Nitroprusside.Approved, Investigational
SitaxentanNitroprusside may increase the hypotensive activities of Sitaxentan.Approved, Investigational, Withdrawn
SpiraprilNitroprusside may increase the hypotensive activities of Spirapril.Approved
TadalafilTadalafil may increase the antihypertensive activities of Nitroprusside.Approved, Investigational
TalinololNitroprusside may increase the hypotensive activities of Talinolol.Investigational
Technetium Tc-99m oxidronateNitroprusside can cause a decrease in the absorption of Technetium Tc-99m oxidronate resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
TelmisartanNitroprusside may increase the hypotensive activities of Telmisartan.Approved, Investigational
TemocaprilNitroprusside may increase the hypotensive activities of Temocapril.Experimental, Investigational
TerlipressinNitroprusside may increase the hypotensive activities of Terlipressin.Approved, Investigational
TerodilineTerodiline may increase the hypotensive activities of Nitroprusside.Experimental
TetrahydropalmatineTetrahydropalmatine may increase the hypotensive activities of Nitroprusside.Investigational
TheodrenalineNitroprusside may increase the hypotensive activities of Theodrenaline.Investigational
TiboloneNitroprusside may increase the hypotensive activities of Tibolone.Approved, Investigational
TicrynafenNitroprusside may increase the hypotensive activities of Ticrynafen.Withdrawn
TimololNitroprusside may increase the hypotensive activities of Timolol.Approved
TolazolineNitroprusside may increase the hypotensive activities of Tolazoline.Approved, Vet Approved
Tolfenamic AcidTolfenamic Acid may increase the hypotensive activities of Nitroprusside.Approved
TolonidineNitroprusside may increase the hypotensive activities of Tolonidine.Experimental
ToloxatoneToloxatone may increase the hypotensive activities of Nitroprusside.Approved
TorasemideNitroprusside may increase the hypotensive activities of Torasemide.Approved
TrandolaprilNitroprusside may increase the hypotensive activities of Trandolapril.Approved
TranilastTranilast may increase the hypotensive activities of Nitroprusside.Approved, Investigational
Trans-2-PhenylcyclopropylamineTrans-2-Phenylcyclopropylamine may increase the hypotensive activities of Nitroprusside.Experimental
TranylcypromineTranylcypromine may increase the hypotensive activities of Nitroprusside.Approved
TravoprostNitroprusside may increase the hypotensive activities of Travoprost.Approved
TreprostinilNitroprusside may increase the hypotensive activities of Treprostinil.Approved, Investigational
TrichlormethiazideNitroprusside may increase the hypotensive activities of Trichlormethiazide.Approved, Vet Approved
TrimazosinNitroprusside may increase the hypotensive activities of Trimazosin.Experimental
TrimethaphanNitroprusside may increase the hypotensive activities of Trimethaphan.Approved, Investigational
UdenafilUdenafil may increase the antihypertensive activities of Nitroprusside.Approved, Investigational
UnoprostoneNitroprusside may increase the hypotensive activities of Unoprostone.Approved, Investigational
UrapidilNitroprusside may increase the hypotensive activities of Urapidil.Investigational
ValsartanNitroprusside may increase the hypotensive activities of Valsartan.Approved, Investigational
VardenafilVardenafil may increase the antihypertensive activities of Nitroprusside.Approved
VerapamilVerapamil may increase the hypotensive activities of Nitroprusside.Approved
VincamineNitroprusside may increase the hypotensive activities of Vincamine.Experimental
VinpocetineVinpocetine may increase the hypotensive activities of Nitroprusside.Investigational
XipamideNitroprusside may increase the hypotensive activities of Xipamide.Experimental
XylometazolineXylometazoline may increase the hypotensive activities of Nitroprusside.Approved
YohimbineYohimbine may decrease the antihypertensive activities of Nitroprusside.Approved, Vet Approved
ZiconotideZiconotide may increase the hypotensive activities of Nitroprusside.Approved
ZofenoprilNitroprusside may increase the hypotensive activities of Zofenopril.Experimental
Food Interactions
Not Available

References

General References
Not Available
External Links
Human Metabolome Database
HMDB0014470
KEGG Compound
C07269
PubChem Compound
11963622
PubChem Substance
46508965
ChemSpider
21607452
BindingDB
50377921
ChEBI
7596
ChEMBL
CHEMBL2097081
Therapeutic Targets Database
DNC001351
PharmGKB
PA451406
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Nitroprusside
ATC Codes
C02DD01 — Nitroprusside
AHFS Codes
  • 24:08.20 — Direct Vasodilators
MSDS
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Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedNot AvailableAging1
1CompletedBasic ScienceSarcopenia2
1CompletedBasic ScienceSchizophrenic Disorders1
1TerminatedOtherInflammatory Reaction1
1Unknown StatusTreatmentAcute Lung Injury (ALI) / Acute Respiratory Distress Syndrome (ARDS) / Arterial hypoxia / Respiratory Failure / Sodium Nitroprusside1
2CompletedTreatmentArterial Hypotension1
2CompletedTreatmentCerebral Oxygenation1
2CompletedTreatmentHigh Blood Pressure (Hypertension)1
2CompletedTreatmentSchizophrenic Disorders1
2RecruitingPreventionStress Disorders, Post-Traumatic1
2RecruitingTreatmentDepression1
2RecruitingTreatmentSchizophrenic Disorders1
2TerminatedDiagnosticHyperlipidemias1
2, 3CompletedTreatmentMyocardial Infarction (MI)1
3CompletedTreatmentHeart Failure, Unspecified / High Blood Pressure (Hypertension)1
3CompletedTreatmentHigh Blood Pressure (Hypertension)1
4Not Yet RecruitingTreatmentAcute Heart Failure (AHF)1
4TerminatedPreventionMyocardial Infarction (MI)1
4Unknown StatusScreeningNitroprusside / Thyroid Hormones1
Not AvailableCompletedNot AvailableCancers / Endothelial Dysfunction / High Blood Pressure (Hypertension)1
Not AvailableCompletedNot AvailableHealthy Volunteers1
Not AvailableCompletedNot AvailableHypotension, Controlled1
Not AvailableCompletedNot AvailableIntracerebral Hemorrhage / Subarachnoid Hemorrhage1
Not AvailableCompletedBasic ScienceHeart Diseases / Heart Failure, Unspecified / Vasodilatation1
Not AvailableCompletedBasic ScienceHeart Diseases / Vasodilation1
Not AvailableCompletedTreatmentCVA (Cerebrovascular Accident) / Intracerebral Hemorrhage / Intracranial Hemorrhages1
Not AvailableCompletedTreatmentType 2 Diabetes Mellitus1
Not AvailableRecruitingNot AvailableLeiomyomas1
Not AvailableTerminatedBasic ScienceProphylaxis of cardiomyopathy / Stress-induced (Takotsubo) Cardiomyopathy1
Not AvailableUnknown StatusNot AvailableDiabetes Mellitus (DM)1

Pharmacoeconomics

Manufacturers
  • Hoffmann la roche inc
  • Abbott laboratories
  • Abbott laboratories pharmaceutical products div
  • Hospira inc
  • Abraxis pharmaceutical products
  • Baxter healthcare corp anesthesia and critical care
  • Teva parenteral medicines inc
Packagers
Dosage forms
FormRouteStrength
Powder, for solutionIntravenous50 mg
Injection, solutionIntravenous.5 mg/mL
Injection, solution, concentrateIntravenous50 mg/2mL
InjectionIntravenous25 mg/mL
InjectionIntravenous50 mg/2mL
Injection, solution, concentrateIntravenous25 mg/mL
SolutionIntravenous25 mg
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP0.071ChemAxon
pKa (Strongest Basic)-3.3ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area148.38 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity39.44 m3·mol-1ChemAxon
Polarizability16.52 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption-0.8308
Blood Brain Barrier+0.9314
Caco-2 permeable-0.5269
P-glycoprotein substrateNon-substrate0.8966
P-glycoprotein inhibitor INon-inhibitor0.919
P-glycoprotein inhibitor IINon-inhibitor0.9767
Renal organic cation transporterNon-inhibitor0.9109
CYP450 2C9 substrateNon-substrate0.8573
CYP450 2D6 substrateNon-substrate0.8353
CYP450 3A4 substrateNon-substrate0.6675
CYP450 1A2 substrateNon-inhibitor0.6719
CYP450 2C9 inhibitorNon-inhibitor0.8599
CYP450 2D6 inhibitorNon-inhibitor0.9186
CYP450 2C19 inhibitorNon-inhibitor0.8218
CYP450 3A4 inhibitorNon-inhibitor0.9763
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9583
Ames testNon AMES toxic0.5204
CarcinogenicityCarcinogens 0.6595
BiodegradationNot ready biodegradable0.5759
Rat acute toxicity2.9543 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9345
hERG inhibition (predictor II)Non-inhibitor0.9596
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as organic transition metal salts. These are organic salt compounds containing a transition metal atom in its ionic form.
Kingdom
Organic compounds
Super Class
Organic salts
Class
Organic metal salts
Sub Class
Organic transition metal salts
Direct Parent
Organic transition metal salts
Alternative Parents
Organotransition metal compounds / Organopnictogen compounds / Organonitrogen compounds / Organic oxides / Hydrocarbon derivatives / Organic anions
Substituents
Organic transition metal salt / Organic nitrogen compound / Organic oxygen compound / Organopnictogen compound / Organic oxide / Hydrocarbon derivative / Organonitrogen compound / Organometallic compound / Organic transition metal moeity / Organic anion
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
iron coordination entity (CHEBI:7596)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Agonist
General Function
Protein kinase activity
Specific Function
Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate ...
Gene Name
NPR1
Uniprot ID
P16066
Uniprot Name
Atrial natriuretic peptide receptor 1
Molecular Weight
118918.11 Da
References
  1. Fortin Y, De Lean A: Role of cyclic GMP and calcineurin in homologous and heterologous desensitization of natriuretic peptide receptor-A. Can J Physiol Pharmacol. 2006 May;84(5):539-46. [PubMed:16902599]
  2. Madhani M, Okorie M, Hobbs AJ, MacAllister RJ: Reciprocal regulation of human soluble and particulate guanylate cyclases in vivo. Br J Pharmacol. 2006 Nov;149(6):797-801. Epub 2006 Oct 3. [PubMed:17016498]
  3. Steinmetz M, Potthast R, Sabrane K, Kuhn M: Diverging vasorelaxing effects of C-type natriuretic peptide in renal resistance arteries and aortas of GC-A-deficient mice. Regul Pept. 2004 Jun 15;119(1-2):31-7. [PubMed:15093694]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Vitamin d 24-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1A1
Uniprot ID
P04798
Uniprot Name
Cytochrome P450 1A1
Molecular Weight
58164.815 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP1A2
Uniprot ID
P05177
Uniprot Name
Cytochrome P450 1A2
Molecular Weight
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]

Drug created on June 13, 2005 07:24 / Updated on January 22, 2018 10:45