Indicators and Reagents

Name
Indicators and Reagents
Accession Number
DBCAT000197
Description

Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)

Drugs
DrugDrug Description
Capromab pendetideA monoclonal anti-prostate specific membrane antigen antibody used in imaging kits to target radioactive agents to malignant prostate tissue.
AmsacrineA cytotoxic agent used to induce remission in acute adult leukemia that is not adequately responsive to other agents.
MitomycinAn antimetabolite used as an adjunct to ab externo (outside approach) eye surgeries for the treatment of glaucoma and used as a chemotherapeutic agent for various malignancies.
NitroprussideA direct acting vasodilator used to treat hypertension, to induce controlled hypotension to reduce postoperative bleeding, and to manage acute heart failure.
Aminohippuric acidA hippuric acid derivative injection utilized in the measurement of effective renal plasma flow (ERPF) and functional capacity of the renal excretory system.
CisplatinA platinum based chemotherapy agent used to treat various sarcomas, carcinomas, lymphomas, and germ cell tumors.
BentiromideIndicated as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy.
MethoxsalenA furocoumarin used to treat psoriasis and vitiligo.
FluoresceinA dye used in angiography or angioscopy of the iris and retina.
CarboplatinA alkylating agent used to treat advanced ovarian cancer.
SorbitolA product that can be used as a laxative to relieve constipation, and also as a urologic irrigating fluid. May also be used as a pharmaceutical sweetener.
DithioerythritolA compound that, along with its isomer, Cleland's reagent (dithiothreitol), is used for the protection of sulfhydryl groups against oxidation to disulfides and for the reduction of disulfides to sulfhydryl...
IsoluminolNot Available
PropidiumQuaternary ammonium analog of ethidium; an intercalating dye with a specific affinity to certain forms of DNA and, used as diiodide, to separate them in density gradients; also forms fluorescent...
1,10-PhenanthrolineNot Available
4-nitrophenyl-beta-D-galactosideNot Available
DansylamideNot Available
Acetic acidAn antimicrobial agent used to treat susceptible infections of the external auditory canal.
Picric acidUsed as antiseptic, astringent, and stimulant for epitheliazation.
Rhodamine 6GNot Available
Oxalic AcidA strong dicarboxylic acid occurring in many plants and vegetables. It is produced in the body by metabolism of glyoxylic acid or ascorbic acid. It is not metabolized but excreted...
Indole-3-Glycerol PhosphateNot Available
4-Nitrophenyl PhosphateNot Available
PhenolphthaleinUsed for over a century as a laxative.
AmonafideInvestigated for use/treatment in breast cancer, ovarian cancer, and prostate cancer.
IobenguaneA radiopharmaceutical agent used for the diagnosis of primary and metastatic pheochromocytoma or neuroblastoma.
PlicamycinFor the treatment of testicular cancer, as well as hypercalcemia and hypercalciuria associated with a variety of advanced forms of cancer.
HymecromoneNot Available
Ferulic acidNot Available
Nitrous acidAn iron binder used to reverse life-threatening acute cyanide poisoning.
Technetium Tc-99m mebrofeninA diagnostic radiopharmaceutical agent used during hepatobiliary imaging tests.
Technetium Tc-99m medronateA diagnostic radiopharmaceutical agent used as a bone imaging agent to delineate areas of altered osteogenesis.
Technetium Tc-99m sestamibiA radiopharmaceutical diagnostic agent used in nuclear medicine imaging tests to detect coronary artery disease and evaluate myocardial function.
Technetium Tc-99m exametazimeA radiopharmaceutical diagnostic agent used as an adjunct for scintigraphy in the detection of altered regional cerebral perfusion in stroke.
Technetium Tc-99m disofeninA radiopharmaceutical diagnostic agent used for hepatobiliary scans.
Technetium Tc-99m pyrophosphateA radiopharmaceutical diagnostic agent used for diagnostic imaging scans for the bones, heart, and gastrointestinal tract.
Technetium Tc-99m pertechnetateA radiocontrast agent used for the identification of various organs, including but not limited to the brain, thyroid, placenta, and bladder.
Technetium Tc-99m sulfur colloidA radiopharmaceutical diagnostic agent used for the localization of lymph nodes, evaluation of peritoneovenous (LeVeen) shunt patency, imaging areas of functioning reticuloendothelial cells, and gastrointestinal imaging.
Iofetamine I-123Not Annotated
Fludeoxyglucose (18F)A radiopharmaceutical agent used for positron emission tomography (PET) imaging in oncology, cardiology, and neurology.
Potassium hydroxideA disinfectant used to clean hands, skin, and surfaces.
DL-dimyristoylphosphatidylcholineDL-dimyristoylphosphatidylcholine is not an active pharmaceutical agent and has no indication.
DithiazanineNot Annotated
AminacrineA highly fluorescent anti-infective dye used clinically as a topical antiseptic and experimentally as a mutagen, due to its interaction with DNA. It is also used as an intracellular pH...
NitrocefinNitrocefin is a chromogenic cephalosporin substrate used to detect the presence of beta-lactamase enzymes, an important mediator of bacterial antibiotic resistance. While other detection methods exist, such as PCR, nitrocefin...
Tuberculin purified protein derivativeA purified protein used in the Mantoux test for Mycobacterium tuberculosis testing.
DinitrochlorobenzeneDinitrochlorobenzene has been used in trials studying the treatment of HIV Infections.
BizelesinBizelesin has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific.
PyrazoloacridinePyrazoloacridine has been used in trials studying the treatment of Lung Cancer, Liver Cancer, Breast Cancer, Melanoma (Skin), and Metastatic Cancer, among others.
PentetreotidePentetreotide has been used in trials studying the diagnostic of cushing syndrome.
PhloroglucinolPhloroglucinol has been used in trials studying the diagnostic of Colonoscopy.
PhenolsulfonphthaleinPhenolsulfonphthalein or otherwise called phenol red is a pH indicator commonly used in cell biology laboratories. Phenolsulfonphthalein is being investigated for use clinically due to its weak estrogen mimicking actions...
SulfobromophthaleinSulfobromophthalein or otherwise called bromsulphthalein is used as a test of liver function in humans .
EosinNot Annotated
Potassium permanganateNot Annotated
Phloxine BFor use in dental disclosing products, allowing for highlighting of bacterial placques.
BronopolAn antimicrobial compound used as a biocide and preservative.
p-PhenylenediamineNot Annotated
TosylchloramideTosylchloramide, also known as chloramine-T, is a chlorinated and deprotonated sulfonamide used as a mild disinfectant. It is not stable in the water dissolved form.
PlatinumPlatinum is under investigation for the treatment of Metastatic Breast Cancer, Non-small Cell Lung Cancer, Gastric Large Cell Neuroendocrine Carcinoma, Colorectal Large Cell Neuroendocrine Carcinoma, and Pancreatic Large Cell Neuroendocrine...
Quinacrine mustardNot Available
GlycocyamineNot Available
Adenosine 5'-[gamma-thio]triphosphateA nucleoside triphosphate analogue that is ATP in which one of the oxygens attached to 3-phosphate group is replaced by sulfur.
GlutaralOne of the protein CROSS-LINKING REAGENTS that is used as a disinfectant for sterilization of heat-sensitive equipment and as a laboratory reagent, especially as a fixative.
Flutemetamol (18F)A radiopharmaceutical diagnostic agent used during Positron Emission Tomography (PET) imaging of the brain to estimate β-amyloid neuritic plaque density in adult patients to diagnose the causes of cognitive impairment.
Technetium Tc-99m tetrofosminTechnetium-99m tetrofosmin is indicated for the diagnosis of heart abnormalities by exercise myocardial scintigraphy. The exercise myocardial scintigraphy is an established method for the diagnosis of the severity of coronary...
Bevacizumab zirconium Zr-89Bevacizumab zirconium Zr-89 is under investigation in clinical trial NCT01338090 (89Zr-bevacizumab PET Imaging in Patients With Neuroendocrine Tumors).
FlutemetamolFlutemetamol is under investigation in clinical trial NCT02353949 (Investigating the Clinical Consequences of Flutemetamol-PET-scanning).
Fluoroazomycin arabinoside F-18Fluoroazomycin arabinoside F-18 is under investigation in clinical trial NCT03257150 (A Study of the Use of Irreversible Electroporation in Pancreatic Ductal Cancer).
AfamelanotideAn injectable subcutaneous implant used to mitigate phototoxicity secondary to erythropoietic protoporphyria (EPP).
Rose bengalIndicated as a diagnostic agent in routine ocular examinations or when superficial conjunctiva or corneal tissue change is suspected, and as an aid in the diagnosis of keratoconjunctivitis sicca, keratitis,...
Brilliant blue GA disclosing agent used in ophthalmological surgery to stain the internal limiting membrane (ILM).
Coumarin 120Not Available
Sinapic acidSinapic acid is a matrix for matrix-assisted laser desorption technique for protein MW determination. It is also a constituent of propolis.
8-anilinonaphthalene-1-sulfonic acidNot Available
Drugs & Drug Targets
DrugTargetType
Capromab pendetideGlutamate carboxypeptidase 2target
AmsacrineDNA topoisomerase 2-alphatarget
AmsacrineDNAtarget
AmsacrinePotassium voltage-gated channel subfamily H member 2target
AmsacrineP-glycoprotein 1transporter
AmsacrineAlpha-1-acid glycoprotein 1target
AmsacrineSerum albumintarget
MitomycinDNAtarget
MitomycinNADPH--cytochrome P450 reductaseenzyme
NitroprussideAtrial natriuretic peptide receptor 1target
NitroprussideCytochrome P450 1A1enzyme
Aminohippuric acidSolute carrier family 22 member 2transporter
Aminohippuric acidSolute carrier family 22 member 5transporter
Aminohippuric acidSolute carrier family 22 member 6transporter
Aminohippuric acidSolute carrier family 22 member 8transporter
Aminohippuric acidCanalicular multispecific organic anion transporter 1transporter
Aminohippuric acidSolute carrier family 22 member 4transporter
Aminohippuric acidSolute carrier family 22 member 11transporter
Aminohippuric acidSolute carrier organic anion transporter family member 3A1transporter
Aminohippuric acidSolute carrier organic anion transporter family member 1B1transporter
Aminohippuric acidMultidrug resistance-associated protein 1transporter
Aminohippuric acidSolute carrier organic anion transporter family member 1A2transporter
Aminohippuric acidMonocarboxylate transporter 1transporter
Aminohippuric acidSolute carrier family 22 member 7transporter
CisplatinDNAtarget
CisplatinCanalicular multispecific organic anion transporter 2transporter
CisplatinMultidrug resistance-associated protein 5transporter
CisplatinCanalicular multispecific organic anion transporter 1transporter
CisplatinSolute carrier family 22 member 2transporter
CisplatinHigh affinity copper uptake protein 1transporter
CisplatinProbable low affinity copper uptake protein 2transporter
CisplatinMultidrug resistance-associated protein 6transporter
CisplatinP-glycoprotein 1transporter
CisplatinCopper-transporting ATPase 2transporter
CisplatinCopper-transporting ATPase 1transporter
CisplatinProstaglandin G/H synthase 2enzyme
CisplatinMyeloperoxidaseenzyme
CisplatinXanthine dehydrogenase/oxidaseenzyme
CisplatinArylamine N-acetyltransferaseenzyme
CisplatinCytochrome P450 2C9enzyme
CisplatinCytochrome P450 2B6enzyme
CisplatinCholinesteraseenzyme
CisplatinCytochrome P450 4A11enzyme
CisplatinATP-binding cassette sub-family G member 2transporter
CisplatinGlutathione S-transferase theta-1enzyme
CisplatinMetallothionein-1Aenzyme
CisplatinMetallothionein-2enzyme
CisplatinSuperoxide dismutase [Cu-Zn]enzyme
CisplatinGlutathione S-transferase Penzyme
CisplatinNAD(P)H dehydrogenase [quinone] 1enzyme
CisplatinGlutathione S-transferase Mu 1enzyme
CisplatinDNA-3-methyladenine glycosylasetarget
CisplatinAlpha-2-macroglobulintarget
CisplatinSerum albumincarrier
CisplatinSerotransferrintarget
CisplatinCopper transport protein ATOX1target
BentiromideSerine protease hepsintarget
MethoxsalenDNAtarget
MethoxsalenCytochrome P450 2A6enzyme
MethoxsalenCytochrome P450 1A2enzyme
MethoxsalenCytochrome P450 1A1enzyme
MethoxsalenCytochrome P450 2A13enzyme
FluoresceinIg kappa chain V-II region RPMI 6410target
FluoresceinDNAtarget
FluoresceinSolute carrier family 22 member 6transporter
FluoresceinBile salt export pumptransporter
FluoresceinMultidrug resistance-associated protein 1transporter
CarboplatinDNAtarget
CarboplatinHigh affinity copper uptake protein 1transporter
CarboplatinProbable low affinity copper uptake protein 2transporter
CarboplatinXanthine dehydrogenase/oxidaseenzyme
CarboplatinMyeloperoxidaseenzyme
CarboplatinGlutathione S-transferase theta-1enzyme
CarboplatinMetallothionein-1Aenzyme
CarboplatinMetallothionein-2enzyme
CarboplatinSuperoxide dismutase [Cu-Zn]enzyme
CarboplatinGlutathione S-transferase Penzyme
CarboplatinGlutathione S-transferase Mu 1enzyme
CarboplatinNAD(P)H dehydrogenase [quinone] 1enzyme
CarboplatinCopper-transporting ATPase 1transporter
CarboplatinCopper-transporting ATPase 2transporter
CarboplatinATP-binding cassette sub-family G member 2transporter
CarboplatinCanalicular multispecific organic anion transporter 1transporter
SorbitolXylose isomerasetarget
SorbitolXylose isomerasetarget
SorbitolXylose isomerasetarget
SorbitolMalate synthase Gtarget
DithioerythritolListeriolysin regulatory proteintarget
Dithioerythritol6,7-dimethyl-8-ribityllumazine synthasetarget
DithioerythritolThymidine kinase, cytosolictarget
IsoluminolQueuine tRNA-ribosyltransferasetarget
PropidiumAcetylcholinesterasetarget
1,10-PhenanthrolineMethyl-accepting chemotaxis protein IItarget
1,10-PhenanthrolineMetallo-beta-lactamase L1target
4-nitrophenyl-beta-D-galactosideGalactoside O-acetyltransferasetarget
4-nitrophenyl-beta-D-galactosideBeta-galactosidasetarget
DansylamideCarbonic anhydrase 2target
Acetic acidSolute carrier organic anion transporter family member 2B1transporter
Acetic acidMonocarboxylate transporter 1transporter
Picric acidPentaerythritol tetranitrate reductasetarget
Rhodamine 6GHTH-type transcriptional regulator QacRtarget
Rhodamine 6GAcriflavine resistance protein Btarget
Rhodamine 6GMultidrug resistance-associated protein 1transporter
Rhodamine 6GP-glycoprotein 1transporter
Oxalic AcidProto-oncogene tyrosine-protein kinase Srctarget
Oxalic AcidSolute carrier organic anion transporter family member 2B1transporter
Oxalic AcidSolute carrier family 22 member 8transporter
Indole-3-Glycerol PhosphateTryptophan synthase alpha chaintarget
Indole-3-Glycerol PhosphateTryptophan synthase beta chaintarget
4-Nitrophenyl PhosphateLow molecular weight phosphotyrosine protein phosphatasetarget
4-Nitrophenyl PhosphateDual specificity protein phosphatase 23target
PhenolphthaleinUDP-glucuronosyltransferase 1-9target
PhenolphthaleinNuclear receptor subfamily 1 group I member 2target
PhenolphthaleinNuclear receptor subfamily 1 group I member 3target
PhenolphthaleinEstrogen receptor alphatarget
PhenolphthaleinSex hormone-binding globulintarget
AmonafideDNA topoisomerase 2-alphatarget
AmonafideDNA topoisomerase 2-betatarget
IobenguaneSodium-dependent noradrenaline transportertransporter
PlicamycinDNAtarget
HymecromoneArylsulfate sulfotransferasetarget
Ferulic acidEndo-1,4-beta-xylanase Ytarget
Ferulic acidEndo-1,4-beta-xylanase Ztarget
Ferulic acidEst1etarget
Ferulic acidO-methyltransferasetarget
Nitrous acidHemoglobin subunit alphatarget
Nitrous acidHemoglobin subunit betatarget
Nitrous acidMyoglobintarget
Technetium Tc-99m mebrofeninSolute carrier organic anion transporter family member 1B1transporter
Technetium Tc-99m mebrofeninSolute carrier organic anion transporter family member 1B3transporter
Technetium Tc-99m sestamibiP-glycoprotein 1transporter
Technetium Tc-99m sestamibiMultidrug resistance-associated protein 1transporter
Technetium Tc-99m pyrophosphateHydroxyapatitetarget
Technetium Tc-99m pyrophosphateAmorphous calcium phosphatetarget
Fludeoxyglucose (18F)Hexokinase-1enzyme
Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 4transporter
Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 2transporter
Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 1transporter
Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 3transporter
Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 9transporter
Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 5transporter
Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 6transporter
Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 7transporter
Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 8transporter
Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 10transporter
Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 11transporter
Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 12transporter
Tuberculin purified protein derivativeToll-like receptor 2target
DinitrochlorobenzeneMethylated-DNA--protein-cysteine methyltransferasetarget
DinitrochlorobenzeneGlutathione S-transferase Ptarget
BronopolThiol groupstarget
Quinacrine mustardTrypanothione reductasetarget
GlycocyamineGuanidinoacetate N-methyltransferasetarget
Adenosine 5'-[gamma-thio]triphosphateProtein RecAtarget
Adenosine 5'-[gamma-thio]triphosphateADP-ribosyl cyclase 2target
Adenosine 5'-[gamma-thio]triphosphateProtein RecAtarget
Adenosine 5'-[gamma-thio]triphosphateProtein RecAtarget
Adenosine 5'-[gamma-thio]triphosphateSynapsin-1target
Adenosine 5'-[gamma-thio]triphosphate[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrialtarget
Adenosine 5'-[gamma-thio]triphosphateChloramphenicol 3-O phosphotransferasetarget
Adenosine 5'-[gamma-thio]triphosphatePhosphoribosylglycinamide formyltransferase 2target
Adenosine 5'-[gamma-thio]triphosphate6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1target
Adenosine 5'-[gamma-thio]triphosphateSerine/threonine-protein kinase PknBtarget
Adenosine 5'-[gamma-thio]triphosphateATP-dependent DNA helicase RecQtarget
Adenosine 5'-[gamma-thio]triphosphateCag alphatarget
Adenosine 5'-[gamma-thio]triphosphateMismatch repair endonuclease PMS2target
Adenosine 5'-[gamma-thio]triphosphateDNA polymerase III subunit tautarget
Flutemetamol (18F)Amyloid beta A4 proteintarget
Technetium Tc-99m tetrofosminP-glycoprotein 1carrier
AfamelanotideMelanocyte-stimulating hormone receptortarget
Rose bengalSerum albumincarrier
Rose bengalLactotransferrincarrier
Rose bengalSerotransferrincarrier
Rose bengalLysozyme Cenzyme
Brilliant blue GInternal limiting membrane (ILM)target
Coumarin 120Peptidyl-prolyl cis-trans isomerase Atarget
Coumarin 120Peptidyl-prolyl cis-trans isomerase F, mitochondrialtarget
Coumarin 120Histone deacetylase 8target
Sinapic acidEndo-1,4-beta-xylanase Ytarget
8-anilinonaphthalene-1-sulfonic acidUDP-N-acetylglucosamine 1-carboxyvinyltransferasetarget
8-anilinonaphthalene-1-sulfonic acidFatty acid-binding protein, adipocytecarrier
8-anilinonaphthalene-1-sulfonic acidProtein S100-A7target
8-anilinonaphthalene-1-sulfonic acidTransthyretincarrier