Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)
DrugDrug NameDrug Indication
DB11153Potassium hydroxideNot Available
DB11163PicrateNot Available
DB11182Rose bengalNot Available
DB11561AminacrineNot Available
DB11592NitrocefinNot Available
DB11601Tuberculin Purified Protein DerivativeIndicated as a diagnostic agent in Mantoux Test used to detect infection with *Mycobacterium tuberculosis*.
DB11831DinitrochlorobenzeneNot Available
DB12352BizelesinNot Available
DB12549PyrazoloacridineNot Available
DB12602PentetreotideNot Available
DB12944PhloroglucinolNot Available
DB00089Capromab pendetideFor diagnosis of prostate cancer and detection of intra-pelvic metastases.
DB00276AmsacrineFor treatment of acute myeloid leukaemia.
DB00305MitomycinFor treatment of malignant neoplasm of lip, oral cavity, pharynx, digestive organs, peritoneum, female breast, and urinary bladder. Also used as an adjunct to ab externo glaucoma surgery.
DB00325NitroprussideFor immediate reduction of blood pressure of patients in hypertensive crises, reduce bleeding during surgery, and for the treatment of acute congestive heart failure
DB00345Aminohippuric acidUsed to measure effective renal plasma flow (ERPF) and to determine the functional capacity of the tubular excretory mechanism.
DB00515CisplatinFor the treatment of metastatic testicular tumors, metastatic ovarian tumors and advanced bladder cancer.
DB00522BentiromideUsed as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy.
DB00553MethoxsalenFor the treatment of psoriasis and vitiligo
DB00693FluoresceinFor diagnostic imaging. Primarily indicated in diagnostic fluorescein angiography or angioscopy of the fundus and of the iris vasculature.
DB00958CarboplatinFor the initial treatment of advanced ovarian carcinoma in established combination with other approved chemotherapeutic agents. One established combination regimen consists of PARAPLATIN and cyclophosphamide. It is also indicated for the palliative treatment of patients with ovarian carcinoma recurrent after prior chemotherapy, including patients who have been previously treated with cisplatin.
DB01638SorbitolUsed as a non-stimulant laxative via an oral suspension or enema.
DB01692DithioerythritolNot Available
DB01839Propylene glycolNot Available
DB02041IsoluminolNot Available
DB02166PropidiumNot Available
DB02254Trifluoro-thiamin phosphateNot Available
DB023651,10-PhenanthrolineNot Available
DB026324-nitrophenyl-beta-D-galactosideNot Available
DB02866DansylamideNot Available
DB02967N-EthylmaleimideNot Available
DB03166Acetic acidUsed to treat infections in the ear canal.
DB03608DiminazeneNot Available
DB03651Picric acidNot Available
DB03825Rhodamine 6GNot Available
DB03902Oxalic AcidNot Available
DB04143Indole-3-Glycerol PhosphateNot Available
DB042144-Nitrophenyl PhosphateNot Available
DB04824PhenolphthaleinUsed for over a century as a laxative.
DB05022AmonafideInvestigated for use/treatment in breast cancer, ovarian cancer, and prostate cancer.
DB06704IobenguaneDetection of primary and metastatic pheochromocytoma or neuroblastoma
DB06810PlicamycinFor the treatment of testicular cancer, as well as hypercalcemia and hypercalciuria associated with a variety of advanced forms of cancer.
DB07118HymecromoneNot Available
DB07767Ferulic acidNot Available
DB09112Sodium NitriteFor sequential use with sodium thiosulfate for the treatment of acute cyanide poisoning that is judged to be life-threatening [FDA Label].
DB09137Technetium Tc-99m mebrofeninTechnetium Tc 99m Mebrofenin is indicated as a hepatobiliary imaging agent.
DB09138Technetium Tc-99m medronateTechnetium Tc 99m Medronate is indicated for use as a bone imaging agent to delineate areas of altered osteogenesis.
DB09161Technetium Tc-99m sestamibiTechnetium Tc 99m Sestamibi is indicated for: 1) detecting coronary artery disease by localizing myocardial ischemia (reversible defects) and infarction (non-reversible defects); and 2) evaluating myocardial function and developing information for use in patient management decisions.
DB09163Technetium Tc-99m exametazimeTechnetium Tc99m exametazime scintigraphy (with or without methylene blue stabilization) may be useful as an adjunct in the detection of altered regional cerebral perfusion in stroke. Tc99m exametazime without methylene blue stabilization is indicated for leukocyte labeled scintigraphy as an adjunct in the localization of intra-abdominal infection and inflammatory bowel disease.
DB09164Technetium Tc-99m disofeninTechnetium Tc99m Disofenin is indicated as a hepatobiliary imaging agent. Hepatolite is indicated in the diagnosis of acute cholecystitis as well as to rule out the occurrence of acute cholecystitis in suspected patients with right upper quadrant pain, fever, jaundice, right upper quadrant tenderness and mass or rebound tenderness, but not limited to these signs and symptoms.
DB09165Technetium Tc-99m pyrophosphateFor use as a skeletal imaging agent used to demonstrate areas of altered osteogenesis, and a cardiac imaging agent used as an adjunct in the diagnosis of acute myocardial infarction [FDA Label]. May also be used to image gated blood pools and detect gastrointetinal bleeding.
DB09314Technetium Tc-99m pertechnetateSodium Pertechnetate Tc99m Injection is indicated for use in adults for imaging in the following tissues: thyroid, salivary gland, urinary bladder (for detection of vesico-ureteral reflux), and nasolacrimal drainage system (dacryoscintigraphy). It is indicated for use in children for imaging the following tissues: thyroid and urinary bladder.
DB09397Technetium Tc-99m sulfur colloidTechnetium 99m sulfur colloid is indicated as a diagnostic agent in adults for the following tests: localization of lymph nodes draining a primary tumor in patients with breast cancer or malignant melanoma; and evaluation of peritoneo-venous (LeVeen) shunt patency. It is indicated in both adult and pediatric patients for: imaging areas of functioning reticuloendothelial cells in the liver, spleen and bone marrow; and studies of esophageal transit and gastroesophageal reflux, and detection of pulmonary aspiration of gastric contents.
DB09502Fludeoxyglucose F-18The uptake of 18F-FDG by tissues is a marker for the tissue uptake of glucose, which in turn is closely correlated with certain types of tissue metabolism. Fludeoxyglucose F 18 Injection is indicated in positron emission tomography (PET) imaging for assessment of abnormal glucose metabolism to assist in the evaluation of malignancy in patients with known or suspected abnormalities found by other testing modalities, or in patients with an existing diagnoses of cancer.
DrugDrug NameTargetType
DB11601Tuberculin Purified Protein DerivativeToll-like receptor 2target
DB11831DinitrochlorobenzeneMethylated-DNA--protein-cysteine methyltransferasetarget
DB11831DinitrochlorobenzeneGlutathione S-transferase Ptarget
DB00089Capromab pendetideGlutamate carboxypeptidase 2target
DB00276AmsacrineDNA topoisomerase 2-alphatarget
DB00276AmsacrineDNAtarget
DB00276AmsacrinePotassium voltage-gated channel subfamily H member 2target
DB00276AmsacrineMultidrug resistance protein 1transporter
DB00276AmsacrineCytochrome P450 2D6enzyme
DB00276AmsacrineAlpha-1-acid glycoprotein 1target
DB00276AmsacrineSerum albumintarget
DB00305MitomycinDNAtarget
DB00305MitomycinNADPH--cytochrome P450 reductaseenzyme
DB00305MitomycinMultidrug resistance protein 1transporter
DB00325NitroprussideAtrial natriuretic peptide receptor 1target
DB00325NitroprussideCytochrome P450 1A1enzyme
DB00325NitroprussideCytochrome P450 1A2enzyme
DB00345Aminohippuric acidSolute carrier family 22 member 2transporter
DB00345Aminohippuric acidSolute carrier family 22 member 1transporter
DB00345Aminohippuric acidSolute carrier family 22 member 5transporter
DB00345Aminohippuric acidMultidrug resistance protein 1transporter
DB00345Aminohippuric acidSolute carrier family 22 member 6transporter
DB00345Aminohippuric acidSolute carrier family 22 member 8transporter
DB00345Aminohippuric acidCanalicular multispecific organic anion transporter 1transporter
DB00345Aminohippuric acidSolute carrier family 22 member 4transporter
DB00345Aminohippuric acidSolute carrier family 22 member 11transporter
DB00345Aminohippuric acidSolute carrier organic anion transporter family member 3A1transporter
DB00345Aminohippuric acidSolute carrier organic anion transporter family member 1B1transporter
DB00345Aminohippuric acidMultidrug resistance-associated protein 1transporter
DB00345Aminohippuric acidSolute carrier organic anion transporter family member 1A2transporter
DB00345Aminohippuric acidMonocarboxylate transporter 1transporter
DB00345Aminohippuric acidSolute carrier family 22 member 7transporter
DB00515CisplatinDNAtarget
DB00515CisplatinCanalicular multispecific organic anion transporter 2transporter
DB00515CisplatinMultidrug resistance-associated protein 5transporter
DB00515CisplatinCanalicular multispecific organic anion transporter 1transporter
DB00515CisplatinSolute carrier family 22 member 2transporter
DB00515CisplatinHigh affinity copper uptake protein 1transporter
DB00515CisplatinProbable low affinity copper uptake protein 2transporter
DB00515CisplatinMultidrug resistance-associated protein 6transporter
DB00515CisplatinMultidrug resistance protein 1transporter
DB00515CisplatinCopper-transporting ATPase 2transporter
DB00515CisplatinCopper-transporting ATPase 1transporter
DB00515CisplatinProstaglandin G/H synthase 2enzyme
DB00515CisplatinMyeloperoxidaseenzyme
DB00515CisplatinXanthine dehydrogenase/oxidaseenzyme
DB00515CisplatinArylamine N-acetyltransferaseenzyme
DB00515CisplatinCytochrome P450 2C9enzyme
DB00515CisplatinCytochrome P450 2B6enzyme
DB00515CisplatinCholinesteraseenzyme
DB00515CisplatinCytochrome P450 4A11enzyme
DB00515CisplatinATP-binding cassette sub-family G member 2transporter
DB00515CisplatinGlutathione S-transferase theta-1enzyme
DB00515CisplatinMetallothionein-1Aenzyme
DB00515CisplatinMetallothionein-2enzyme
DB00515CisplatinSuperoxide dismutase [Cu-Zn]enzyme
DB00515CisplatinGlutathione S-transferase Penzyme
DB00515CisplatinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00515CisplatinGlutathione S-transferase Mu 1enzyme
DB00515CisplatinDNA-3-methyladenine glycosylasetarget
DB00515CisplatinAlpha-2-macroglobulintarget
DB00515CisplatinSerum albumincarrier
DB00515CisplatinSerotransferrintarget
DB00515CisplatinCopper transport protein ATOX1target
DB00522BentiromideSerine protease hepsintarget
DB00553MethoxsalenDNAtarget
DB00553MethoxsalenCytochrome P450 2A6enzyme
DB00553MethoxsalenCytochrome P450 1A2enzyme
DB00553MethoxsalenCytochrome P450 1A1enzyme
DB00553MethoxsalenCytochrome P450 2A13enzyme
DB00553MethoxsalenCytochrome P450 3A4enzyme
DB00553MethoxsalenCytochrome P450 2D6enzyme
DB00693FluoresceinIg kappa chain V-II region RPMI 6410target
DB00693FluoresceinDNAtarget
DB00693FluoresceinSolute carrier family 22 member 6transporter
DB00693FluoresceinBile salt export pumptransporter
DB00693FluoresceinMultidrug resistance-associated protein 1transporter
DB00693FluoresceinCytochrome P450 1A1enzyme
DB00958CarboplatinDNAtarget
DB00958CarboplatinHigh affinity copper uptake protein 1transporter
DB00958CarboplatinProbable low affinity copper uptake protein 2transporter
DB00958CarboplatinXanthine dehydrogenase/oxidaseenzyme
DB00958CarboplatinMyeloperoxidaseenzyme
DB00958CarboplatinGlutathione S-transferase theta-1enzyme
DB00958CarboplatinMetallothionein-1Aenzyme
DB00958CarboplatinMetallothionein-2enzyme
DB00958CarboplatinSuperoxide dismutase [Cu-Zn]enzyme
DB00958CarboplatinGlutathione S-transferase Penzyme
DB00958CarboplatinGlutathione S-transferase Mu 1enzyme
DB00958CarboplatinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00958CarboplatinCopper-transporting ATPase 1transporter
DB00958CarboplatinCopper-transporting ATPase 2transporter
DB00958CarboplatinATP-binding cassette sub-family G member 2transporter
DB00958CarboplatinCanalicular multispecific organic anion transporter 1transporter
DB01638SorbitolXylose isomerasetarget
DB01638SorbitolXylose isomerasetarget
DB01638SorbitolXylose isomerasetarget
DB01638SorbitolMalate synthase Gtarget
DB01692DithioerythritolListeriolysin regulatory proteintarget
DB01692Dithioerythritol6,7-dimethyl-8-ribityllumazine synthasetarget
DB01692DithioerythritolThymidine kinase, cytosolictarget
DB01839Propylene glycolCoagulation factor XIII A chaintarget
DB01839Propylene glycolHaloalkane dehalogenasetarget
DB01839Propylene glycolClavaminate synthase 1target
DB01839Propylene glycolLactaldehyde reductasetarget
DB01839Propylene glycolB12-independent glycerol dehydratasetarget
DB02041IsoluminolQueuine tRNA-ribosyltransferasetarget
DB02166PropidiumAcetylcholinesterasetarget
DB02254Trifluoro-thiamin phosphateThiamine-phosphate synthasetarget
DB023651,10-PhenanthrolineMethyl-accepting chemotaxis protein IItarget
DB023651,10-PhenanthrolineMetallo-beta-lactamase L1target
DB026324-nitrophenyl-beta-D-galactosideGalactoside O-acetyltransferasetarget
DB026324-nitrophenyl-beta-D-galactosideBeta-galactosidasetarget
DB02866DansylamideCarbonic anhydrase 2target
DB02967N-EthylmaleimideGalectin-10target
DB03166Acetic acidSolute carrier organic anion transporter family member 2B1transporter
DB03166Acetic acidMonocarboxylate transporter 1transporter
DB03608DiminazenePeroxiredoxin-5, mitochondrialtarget
DB03608DiminazeneHTH-type transcriptional regulator QacRtarget
DB03608DiminazeneTrypsin-1target
DB03608DiminazeneAmiloride-sensitive amine oxidase [copper-containing]target
DB03651Picric acidPentaerythritol tetranitrate reductasetarget
DB03825Rhodamine 6GHTH-type transcriptional regulator QacRtarget
DB03825Rhodamine 6GAcriflavine resistance protein Btarget
DB03825Rhodamine 6GMultidrug resistance-associated protein 1transporter
DB03902Oxalic AcidProto-oncogene tyrosine-protein kinase Srctarget
DB03902Oxalic AcidSolute carrier organic anion transporter family member 2B1transporter
DB03902Oxalic AcidSolute carrier family 22 member 8transporter
DB04143Indole-3-Glycerol PhosphateTryptophan synthase alpha chaintarget
DB04143Indole-3-Glycerol PhosphateTryptophan synthase beta chaintarget
DB042144-Nitrophenyl PhosphateLow molecular weight phosphotyrosine protein phosphatasetarget
DB042144-Nitrophenyl PhosphateDual specificity protein phosphatase 23target
DB04824PhenolphthaleinUDP-glucuronosyltransferase 1-9target
DB04824PhenolphthaleinNuclear receptor subfamily 1 group I member 2target
DB04824PhenolphthaleinNuclear receptor subfamily 1 group I member 3target
DB04824PhenolphthaleinEstrogen receptor alphatarget
DB04824PhenolphthaleinSex hormone-binding globulintarget
DB05022AmonafideDNA topoisomerase 2-alphatarget
DB05022AmonafideDNA topoisomerase 2-betatarget
DB06704IobenguaneSodium-dependent noradrenaline transportertransporter
DB06810PlicamycinDNAtarget
DB07118HymecromoneArylsulfate sulfotransferasetarget
DB07767Ferulic acidEndo-1,4-beta-xylanase Ytarget
DB07767Ferulic acidEndo-1,4-beta-xylanase Ztarget
DB07767Ferulic acidEst1etarget
DB07767Ferulic acidO-methyltransferasetarget
DB09112Sodium NitriteHemoglobin subunit alphatarget
DB09112Sodium NitriteHemoglobin subunit betatarget
DB09112Sodium NitriteMyoglobintarget
DB09137Technetium Tc-99m mebrofeninSolute carrier organic anion transporter family member 1B1transporter
DB09137Technetium Tc-99m mebrofeninSolute carrier organic anion transporter family member 1B3transporter
DB09161Technetium Tc-99m sestamibiMultidrug resistance protein 1transporter
DB09161Technetium Tc-99m sestamibiMultidrug resistance-associated protein 1transporter
DB09165Technetium Tc-99m pyrophosphateHydroxyapatitetarget
DB09165Technetium Tc-99m pyrophosphateAmorphous calcium phosphatetarget
DB09502Fludeoxyglucose F-18Hexokinase-1enzyme
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 4transporter
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 2transporter
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 1transporter
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 3transporter
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 9transporter
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 5transporter
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 6transporter
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 7transporter
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 8transporter
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 10transporter
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 11transporter
DB09502Fludeoxyglucose F-18Solute carrier family 2, facilitated glucose transporter member 12transporter