Indicators and Reagents

Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)
DrugDrug NameDrug Description
DB00089Capromab pendetideA monoclonal anti-prostate specific membrane antigen antibody used in imaging kits to target radioactive agents to malignant prostate tissue.
DB00276AmsacrineA cytotoxic agent used to induce remission in acute adult leukemia that is not adequately responsive to other agents.
DB00305MitomycinAn antimetabolite used as an adjunct to ab externo (outside approach) eye surgeries for the treatment of glaucoma and used as a chemotherapeutic agent for various malignancies.
DB00325NitroprussideA direct acting vasodilator used to treat hypertension, to induce controlled hypotension to reduce postoperative bleeding, and to manage acute heart failure.
DB00345Aminohippuric acidA hippuric acid derivative injection utilized in the measurement of effective renal plasma flow (ERPF) and functional capacity of the renal excretory system.
DB00515CisplatinA platinum based chemotherapy agent used to treat various sarcomas, carcinomas, lymphomas, and germ cell tumors.
DB00522BentiromideIndicated as a screening test for exocrine pancreatic insufficiency and to monitor the adequacy of supplemental pancreatic therapy.
DB00553MethoxsalenA furocoumarin used to treat psoriasis and vitiligo.
DB00693FluoresceinA dye used in angiography or angioscopy of the iris and retina.
DB00958CarboplatinA alkylating agent used to treat advanced ovarian cancer.
DB01638SorbitolA product that can be used as a laxative to relieve constipation, and also as a urologic irrigating fluid. May also be used as a pharmaceutical sweetener.
DB01692DithioerythritolA compound that, along with its isomer, Cleland's reagent (dithiothreitol), is used for the protection of sulfhydryl groups against oxidation to disulfides and for the reduction of disulfides to sulfhydryl...
DB02041IsoluminolNot Available
DB02166PropidiumQuaternary ammonium analog of ethidium; an intercalating dye with a specific affinity to certain forms of DNA and, used as diiodide, to separate them in density gradients; also forms fluorescent...
DB023651,10-PhenanthrolineNot Available
DB026324-nitrophenyl-beta-D-galactosideNot Available
DB02866DansylamideNot Available
DB03166Acetic acidAn antimicrobial agent used to treat susceptible infections of the external auditory canal.
DB03651Picric acidUsed as antiseptic, astringent, and stimulant for epitheliazation.
DB03825Rhodamine 6GNot Available
DB03902Oxalic AcidA strong dicarboxylic acid occurring in many plants and vegetables. It is produced in the body by metabolism of glyoxylic acid or ascorbic acid. It is not metabolized but excreted...
DB04143Indole-3-Glycerol PhosphateNot Available
DB042144-Nitrophenyl PhosphateNot Available
DB04824PhenolphthaleinUsed for over a century as a laxative.
DB05022AmonafideInvestigated for use/treatment in breast cancer, ovarian cancer, and prostate cancer.
DB06704IobenguaneA radiopharmaceutical agent used for the diagnosis of primary and metastatic pheochromocytoma or neuroblastoma.
DB06810PlicamycinFor the treatment of testicular cancer, as well as hypercalcemia and hypercalciuria associated with a variety of advanced forms of cancer.
DB07118HymecromoneNot Available
DB07767Ferulic acidNot Available
DB09112Nitrous acidAn iron binder used to reverse life-threatening acute cyanide poisoning.
DB09137Technetium Tc-99m mebrofeninA diagnostic radiopharmaceutical agent used during hepatobiliary imaging tests.
DB09138Technetium Tc-99m medronateA diagnostic radiopharmaceutical agent used as a bone imaging agent to delineate areas of altered osteogenesis.
DB09161Technetium Tc-99m sestamibiA radiopharmaceutical diagnostic agent used in nuclear medicine imaging tests to detect coronary artery disease and evaluate myocardial function.
DB09163Technetium Tc-99m exametazimeA radiopharmaceutical diagnostic agent used as an adjunct for scintigraphy in the detection of altered regional cerebral perfusion in stroke.
DB09164Technetium Tc-99m disofeninA radiopharmaceutical diagnostic agent used for hepatobiliary scans.
DB09165Technetium Tc-99m pyrophosphateA radiopharmaceutical diagnostic agent used for diagnostic imaging scans for the bones, heart, and gastrointestinal tract.
DB09314Technetium Tc-99m pertechnetateA radiocontrast agent used for the identification of various organs, including but not limited to the brain, thyroid, placenta, and bladder.
DB09397Technetium Tc-99m sulfur colloidA radiopharmaceutical diagnostic agent used for the localization of lymph nodes, evaluation of peritoneovenous (LeVeen) shunt patency, imaging areas of functioning reticuloendothelial cells, and gastrointestinal imaging.
DB09480Iofetamine I-123Not Annotated
DB09502Fludeoxyglucose (18F)A radiopharmaceutical agent used for positron emission tomography (PET) imaging in oncology, cardiology, and neurology.
DB11153Potassium hydroxideA disinfectant used to clean hands, skin, and surfaces.
DB11283DL-dimyristoylphosphatidylcholineDL-dimyristoylphosphatidylcholine is not an active pharmaceutical agent and has no indication.
DB11561AminacrineA highly fluorescent anti-infective dye used clinically as a topical antiseptic and experimentally as a mutagen, due to its interaction with DNA. It is also used as an intracellular pH...
DB11592NitrocefinNitrocefin is a chromogenic cephalosporin substrate used to detect the presence of beta-lactamase enzymes, an important mediator of bacterial antibiotic resistance. While other detection methods exist, such as PCR, nitrocefin...
DB11601Tuberculin Purified Protein DerivativeA purified protein used in the Mantoux test for Mycobacterium tuberculosis testing.
DB11831DinitrochlorobenzeneDinitrochlorobenzene has been used in trials studying the treatment of HIV Infections.
DB12352BizelesinBizelesin has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific.
DB12549PyrazoloacridinePyrazoloacridine has been used in trials studying the treatment of Lung Cancer, Liver Cancer, Breast Cancer, Melanoma (Skin), and Metastatic Cancer, among others.
DB12602PentetreotidePentetreotide has been used in trials studying the diagnostic of cushing syndrome.
DB12944PhloroglucinolPhloroglucinol has been used in trials studying the diagnostic of Colonoscopy.
DB13212PhenolsulfonphthaleinPhenolsulfonphthalein or otherwise called phenol red is a pH indicator commonly used in cell biology laboratories. Phenolsulfonphthalein is being investigated for use clinically due to its weak estrogen mimicking actions...
DB13215SulfobromophthaleinSulfobromophthalein or otherwise called bromsulphthalein is used as a test of liver function in humans .
DB13706EosinNot Annotated
DB13831Potassium permanganateNot Annotated
DB13911Phloxine BFor use in dental disclosing products, allowing for highlighting of bacterial placques.
DB13960BronopolAn antimicrobial compound used as a biocide and preservative.
DB14141p-PhenylenediamineNot Annotated
DB14708TosylchloramideTosylchloramide, also known as chloramine-T, is a chlorinated and deprotonated sulfonamide used as a mild disinfectant. It is not stable in the water dissolved form.
DB12257PlatinumPlatinum is under investigation for the treatment of Metastatic Breast Cancer, Non-small Cell Lung Cancer, Gastric Large Cell Neuroendocrine Carcinoma, Colorectal Large Cell Neuroendocrine Carcinoma, and Pancreatic Large Cell Neuroendocrine...
DB02240Quinacrine mustardNot Available
DB02751GlycocyamineNot Available
DB02930Adenosine 5'-[γ-thio]triphosphateA nucleoside triphosphate analogue that is ATP in which one of the oxygens attached to 3-phosphate group is replaced by sulfur.
DB03266GlutaralOne of the protein CROSS-LINKING REAGENTS that is used as a disinfectant for sterilization of heat-sensitive equipment and as a laboratory reagent, especially as a fixative.
DB09151Flutemetamol (18F)A radiopharmaceutical diagnostic agent used during Positron Emission Tomography (PET) imaging of the brain to estimate β-amyloid neuritic plaque density in adult patients to diagnose the causes of cognitive impairment.
DB09160Technetium Tc-99m tetrofosminTechnetium-99m tetrofosmin is indicated for the diagnosis of heart abnormalities by exercise myocardial scintigraphy. The exercise myocardial scintigraphy is an established method for the diagnosis of the severity of coronary...
DB14907Bevacizumab zirconium Zr-89Bevacizumab zirconium Zr-89 is under investigation in clinical trial NCT01338090 (89Zr-bevacizumab PET Imaging in Patients With Neuroendocrine Tumors).
DB15058FlutemetamolFlutemetamol is under investigation in clinical trial NCT02353949 (Investigating the Clinical Consequences of Flutemetamol-PET-scanning).
DB15134Fluoroazomycin arabinoside F-18Fluoroazomycin arabinoside F-18 is under investigation in clinical trial NCT03257150 (A Study of the Use of Irreversible Electroporation in Pancreatic Ductal Cancer).
DB04931AfamelanotideAn injectable subcutaneous implant used to mitigate phototoxicity secondary to erythropoietic protoporphyria (EPP).
DB11182Rose bengalIndicated as a diagnostic agent in routine ocular examinations or when superficial conjunctiva or corneal tissue change is suspected, and as an aid in the diagnosis of keratoconjunctivitis sicca, keratitis,...
DrugDrug NameTargetType
DB00089Capromab pendetideGlutamate carboxypeptidase 2target
DB00276AmsacrineDNA topoisomerase 2-alphatarget
DB00276AmsacrineDNAtarget
DB00276AmsacrinePotassium voltage-gated channel subfamily H member 2target
DB00276AmsacrineP-glycoprotein 1transporter
DB00276AmsacrineAlpha-1-acid glycoprotein 1target
DB00276AmsacrineSerum albumintarget
DB00305MitomycinDNAtarget
DB00305MitomycinNADPH--cytochrome P450 reductaseenzyme
DB00325NitroprussideAtrial natriuretic peptide receptor 1target
DB00325NitroprussideCytochrome P450 1A1enzyme
DB00345Aminohippuric acidSolute carrier family 22 member 2transporter
DB00345Aminohippuric acidSolute carrier family 22 member 5transporter
DB00345Aminohippuric acidSolute carrier family 22 member 6transporter
DB00345Aminohippuric acidSolute carrier family 22 member 8transporter
DB00345Aminohippuric acidCanalicular multispecific organic anion transporter 1transporter
DB00345Aminohippuric acidSolute carrier family 22 member 4transporter
DB00345Aminohippuric acidSolute carrier family 22 member 11transporter
DB00345Aminohippuric acidSolute carrier organic anion transporter family member 3A1transporter
DB00345Aminohippuric acidSolute carrier organic anion transporter family member 1B1transporter
DB00345Aminohippuric acidMultidrug resistance-associated protein 1transporter
DB00345Aminohippuric acidSolute carrier organic anion transporter family member 1A2transporter
DB00345Aminohippuric acidMonocarboxylate transporter 1transporter
DB00345Aminohippuric acidSolute carrier family 22 member 7transporter
DB00515CisplatinDNAtarget
DB00515CisplatinCanalicular multispecific organic anion transporter 2transporter
DB00515CisplatinMultidrug resistance-associated protein 5transporter
DB00515CisplatinCanalicular multispecific organic anion transporter 1transporter
DB00515CisplatinSolute carrier family 22 member 2transporter
DB00515CisplatinHigh affinity copper uptake protein 1transporter
DB00515CisplatinProbable low affinity copper uptake protein 2transporter
DB00515CisplatinMultidrug resistance-associated protein 6transporter
DB00515CisplatinP-glycoprotein 1transporter
DB00515CisplatinCopper-transporting ATPase 2transporter
DB00515CisplatinCopper-transporting ATPase 1transporter
DB00515CisplatinProstaglandin G/H synthase 2enzyme
DB00515CisplatinMyeloperoxidaseenzyme
DB00515CisplatinXanthine dehydrogenase/oxidaseenzyme
DB00515CisplatinArylamine N-acetyltransferaseenzyme
DB00515CisplatinCytochrome P450 2C9enzyme
DB00515CisplatinCytochrome P450 2B6enzyme
DB00515CisplatinCholinesteraseenzyme
DB00515CisplatinCytochrome P450 4A11enzyme
DB00515CisplatinATP-binding cassette sub-family G member 2transporter
DB00515CisplatinGlutathione S-transferase theta-1enzyme
DB00515CisplatinMetallothionein-1Aenzyme
DB00515CisplatinMetallothionein-2enzyme
DB00515CisplatinSuperoxide dismutase [Cu-Zn]enzyme
DB00515CisplatinGlutathione S-transferase Penzyme
DB00515CisplatinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00515CisplatinGlutathione S-transferase Mu 1enzyme
DB00515CisplatinDNA-3-methyladenine glycosylasetarget
DB00515CisplatinAlpha-2-macroglobulintarget
DB00515CisplatinSerum albumincarrier
DB00515CisplatinSerotransferrintarget
DB00515CisplatinCopper transport protein ATOX1target
DB00522BentiromideSerine protease hepsintarget
DB00553MethoxsalenDNAtarget
DB00553MethoxsalenCytochrome P450 2A6enzyme
DB00553MethoxsalenCytochrome P450 1A2enzyme
DB00553MethoxsalenCytochrome P450 1A1enzyme
DB00553MethoxsalenCytochrome P450 2A13enzyme
DB00693FluoresceinIg kappa chain V-II region RPMI 6410target
DB00693FluoresceinDNAtarget
DB00693FluoresceinSolute carrier family 22 member 6transporter
DB00693FluoresceinBile salt export pumptransporter
DB00693FluoresceinMultidrug resistance-associated protein 1transporter
DB00958CarboplatinDNAtarget
DB00958CarboplatinHigh affinity copper uptake protein 1transporter
DB00958CarboplatinProbable low affinity copper uptake protein 2transporter
DB00958CarboplatinXanthine dehydrogenase/oxidaseenzyme
DB00958CarboplatinMyeloperoxidaseenzyme
DB00958CarboplatinGlutathione S-transferase theta-1enzyme
DB00958CarboplatinMetallothionein-1Aenzyme
DB00958CarboplatinMetallothionein-2enzyme
DB00958CarboplatinSuperoxide dismutase [Cu-Zn]enzyme
DB00958CarboplatinGlutathione S-transferase Penzyme
DB00958CarboplatinGlutathione S-transferase Mu 1enzyme
DB00958CarboplatinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00958CarboplatinCopper-transporting ATPase 1transporter
DB00958CarboplatinCopper-transporting ATPase 2transporter
DB00958CarboplatinATP-binding cassette sub-family G member 2transporter
DB00958CarboplatinCanalicular multispecific organic anion transporter 1transporter
DB01638SorbitolXylose isomerasetarget
DB01638SorbitolXylose isomerasetarget
DB01638SorbitolXylose isomerasetarget
DB01638SorbitolMalate synthase Gtarget
DB01692DithioerythritolListeriolysin regulatory proteintarget
DB01692Dithioerythritol6,7-dimethyl-8-ribityllumazine synthasetarget
DB01692DithioerythritolThymidine kinase, cytosolictarget
DB02041IsoluminolQueuine tRNA-ribosyltransferasetarget
DB02166PropidiumAcetylcholinesterasetarget
DB023651,10-PhenanthrolineMethyl-accepting chemotaxis protein IItarget
DB023651,10-PhenanthrolineMetallo-beta-lactamase L1target
DB026324-nitrophenyl-beta-D-galactosideGalactoside O-acetyltransferasetarget
DB026324-nitrophenyl-beta-D-galactosideBeta-galactosidasetarget
DB02866DansylamideCarbonic anhydrase 2target
DB03166Acetic acidSolute carrier organic anion transporter family member 2B1transporter
DB03166Acetic acidMonocarboxylate transporter 1transporter
DB03651Picric acidPentaerythritol tetranitrate reductasetarget
DB03825Rhodamine 6GHTH-type transcriptional regulator QacRtarget
DB03825Rhodamine 6GAcriflavine resistance protein Btarget
DB03825Rhodamine 6GMultidrug resistance-associated protein 1transporter
DB03902Oxalic AcidProto-oncogene tyrosine-protein kinase Srctarget
DB03902Oxalic AcidSolute carrier organic anion transporter family member 2B1transporter
DB03902Oxalic AcidSolute carrier family 22 member 8transporter
DB04143Indole-3-Glycerol PhosphateTryptophan synthase alpha chaintarget
DB04143Indole-3-Glycerol PhosphateTryptophan synthase beta chaintarget
DB042144-Nitrophenyl PhosphateLow molecular weight phosphotyrosine protein phosphatasetarget
DB042144-Nitrophenyl PhosphateDual specificity protein phosphatase 23target
DB04824PhenolphthaleinUDP-glucuronosyltransferase 1-9target
DB04824PhenolphthaleinNuclear receptor subfamily 1 group I member 2target
DB04824PhenolphthaleinNuclear receptor subfamily 1 group I member 3target
DB04824PhenolphthaleinEstrogen receptor alphatarget
DB04824PhenolphthaleinSex hormone-binding globulintarget
DB05022AmonafideDNA topoisomerase 2-alphatarget
DB05022AmonafideDNA topoisomerase 2-betatarget
DB06704IobenguaneSodium-dependent noradrenaline transportertransporter
DB06810PlicamycinDNAtarget
DB07118HymecromoneArylsulfate sulfotransferasetarget
DB07767Ferulic acidEndo-1,4-beta-xylanase Ytarget
DB07767Ferulic acidEndo-1,4-beta-xylanase Ztarget
DB07767Ferulic acidEst1etarget
DB07767Ferulic acidO-methyltransferasetarget
DB09112Nitrous acidHemoglobin subunit alphatarget
DB09112Nitrous acidHemoglobin subunit betatarget
DB09112Nitrous acidMyoglobintarget
DB09137Technetium Tc-99m mebrofeninSolute carrier organic anion transporter family member 1B1transporter
DB09137Technetium Tc-99m mebrofeninSolute carrier organic anion transporter family member 1B3transporter
DB09161Technetium Tc-99m sestamibiP-glycoprotein 1transporter
DB09161Technetium Tc-99m sestamibiMultidrug resistance-associated protein 1transporter
DB09165Technetium Tc-99m pyrophosphateHydroxyapatitetarget
DB09165Technetium Tc-99m pyrophosphateAmorphous calcium phosphatetarget
DB09502Fludeoxyglucose (18F)Hexokinase-1enzyme
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 4transporter
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 2transporter
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 1transporter
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 3transporter
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 9transporter
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 5transporter
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 6transporter
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 7transporter
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 8transporter
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 10transporter
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 11transporter
DB09502Fludeoxyglucose (18F)Solute carrier family 2, facilitated glucose transporter member 12transporter
DB11601Tuberculin Purified Protein DerivativeToll-like receptor 2target
DB11831DinitrochlorobenzeneMethylated-DNA--protein-cysteine methyltransferasetarget
DB11831DinitrochlorobenzeneGlutathione S-transferase Ptarget
DB13960BronopolThiol groupstarget
DB02240Quinacrine mustardTrypanothione reductasetarget
DB02751GlycocyamineGuanidinoacetate N-methyltransferasetarget
DB02930Adenosine 5'-[γ-thio]triphosphateProtein RecAtarget
DB02930Adenosine 5'-[γ-thio]triphosphateADP-ribosyl cyclase 2target
DB02930Adenosine 5'-[γ-thio]triphosphateProtein RecAtarget
DB02930Adenosine 5'-[γ-thio]triphosphateProtein RecAtarget
DB02930Adenosine 5'-[γ-thio]triphosphateSynapsin-1target
DB02930Adenosine 5'-[γ-thio]triphosphate[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrialtarget
DB02930Adenosine 5'-[γ-thio]triphosphateChloramphenicol 3-O phosphotransferasetarget
DB02930Adenosine 5'-[γ-thio]triphosphatePhosphoribosylglycinamide formyltransferase 2target
DB02930Adenosine 5'-[γ-thio]triphosphate6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1target
DB02930Adenosine 5'-[γ-thio]triphosphateSerine/threonine-protein kinase PknBtarget
DB02930Adenosine 5'-[γ-thio]triphosphateATP-dependent DNA helicase RecQtarget
DB02930Adenosine 5'-[γ-thio]triphosphateCag alphatarget
DB02930Adenosine 5'-[γ-thio]triphosphateMismatch repair endonuclease PMS2target
DB02930Adenosine 5'-[γ-thio]triphosphateDNA polymerase III subunit tautarget
DB09151Flutemetamol (18F)Amyloid beta A4 proteintarget
DB09160Technetium Tc-99m tetrofosminP-glycoprotein 1carrier
DB04931AfamelanotideMelanocyte-stimulating hormone receptortarget
DB11182Rose bengalSerum albumincarrier
DB11182Rose bengalLactotransferrincarrier
DB11182Rose bengalSerotransferrincarrier
DB11182Rose bengalLysozyme Cenzyme