Also known as: Glioblastoma / Glioblastomas
DrugDrug NameDrug Description
DB00262CarmustineA cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
DB09054IdelalisibIdelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination with rituximab in patients for whom rituximab alone would be considered appropriate therapy due to other co-morbidities, while in the treatment of FL and SLL it is intended to be used in patients who have received at least two prior systemic therapies. More specifically, idelalisib targets P110δ, the delta isoform of the enzyme phosphatidylinositol-4,5-bisphosphate 3-kinase, also known as PI-3K. The PI-3Ks are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. In contrast to the other class IA PI3Ks p110α and p110β, p110δ is principally expressed in leukocytes (white blood cells) and is important for the function of T cells, B cell, mast cells and neutrophils. By inhibiting this enzyme, idelalisib induces apoptosis of malignant cells and inhibits several cell signaling pathways, including B-cell receptor (BCR) signaling and C-X-C chemokine receptors type 5 and type 4 signalling, which are involved in trafficking and homing of B-cells to the lymph nodes and bone marrow. Treatment of lymphoma cells with idelalisib has been shown to result in inhibition of chemotaxis and adhesion, and reduced cell viability.
DB00762IrinotecanIrinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cell death. It is a derivative of camptothecin. Irinotecan was approved for the treatment of advanced pancreatic cancer in October, 2015 (irinotecan liposome injection, trade name Onivyde).
DrugDrug NameTargetType
DB00262CarmustineGlutathione reductase, mitochondrialtarget
DB00262CarmustineDNAtarget
DB00262CarmustineCytochrome P450 1A2enzyme
DB00262CarmustineRNAtarget
DB09054IdelalisibAldehyde oxidaseenzyme
DB09054IdelalisibCytochrome p450 3A subfamilyenzyme
DB09054IdelalisibUDP-glucuronosyltransferase 1A4enzyme
DB09054IdelalisibUDP-glucuronosyltransferase 1A1enzyme
DB09054IdelalisibCytochrome P450 2C8enzyme
DB09054IdelalisibCytochrome P450 2C19enzyme
DB09054IdelalisibCytochrome P450 2B6enzyme
DB09054IdelalisibCytochrome P450 3A4enzyme
DB09054IdelalisibPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform (P110δ)target
DB09054IdelalisibATP-binding cassette sub-family G member 2transporter
DB09054IdelalisibMultidrug resistance protein 1transporter
DB09054IdelalisibSolute carrier organic anion transporter family member 1B1transporter
DB09054IdelalisibSolute carrier organic anion transporter family member 1B3transporter
DB00762IrinotecanDNA topoisomerase I, mitochondrialtarget
DB00762IrinotecanDNA topoisomerase 1target
DB00762IrinotecanCytochrome P450 3A4enzyme
DB00762IrinotecanCytochrome P450 3A5enzyme
DB00762IrinotecanUDP-glucuronosyltransferase 1-1enzyme
DB00762IrinotecanUDP-glucuronosyltransferase 1-9enzyme
DB00762IrinotecanLiver carboxylesterase 1enzyme
DB00762IrinotecanCytochrome P450 3A7enzyme
DB00762IrinotecanCytochrome P450 2B6enzyme
DB00762IrinotecanSolute carrier family 22 member 3transporter
DB00762IrinotecanSolute carrier organic anion transporter family member 1B1transporter
DB00762IrinotecanMultidrug resistance-associated protein 1transporter
DB00762IrinotecanATP-binding cassette sub-family G member 2transporter
DB00762IrinotecanSerum albumincarrier
DB00762IrinotecanCocaine esteraseenzyme
DB00762IrinotecanCholinesteraseenzyme
DB00762IrinotecanMultidrug resistance protein 1transporter
DB00762IrinotecanCanalicular multispecific organic anion transporter 1transporter
DrugDrug NamePhaseStatusCount
DB00112Bevacizumab0Recruiting1
DB00112Bevacizumab0Unknown Status1
DB09063Ceritinib0Recruiting1
DB00822Disulfiram0Active Not Recruiting1
DB00822Disulfiram0Not Yet Recruiting1
DB08868Fingolimod0Recruiting1
DB09150Fludeoxyglucose F-180Recruiting1
DB09502Fludeoxyglucose F-180Recruiting1
DB09570Ixazomib0Recruiting1
DB00331Metformin0Not Yet Recruiting1
DB01268Sunitinib0Completed1
DB00853Temozolomide0Active Not Recruiting1
DB08916Afatinib1Active Not Recruiting1
DB00041Aldesleukin1Completed1
DB00673Aprepitant1Recruiting1
DB00995Auranofin1Recruiting1
DB00112Bevacizumab1Completed1
DB00112Bevacizumab1Recruiting2
DB05153Cabozantinib1Completed1
DB08875Cabozantinib1Completed1
DB01101Capecitabine1Recruiting1
DB01197Captopril1Recruiting1
DB00482Celecoxib1Recruiting1
DB12029Chlorogenic Acid1Recruiting1
DB05487Custirsen1Completed1
DB00531Cyclophosphamide1Terminated1
DB00260Cycloserine1Completed1
DB01254Dasatinib1Completed1
DB01254Dasatinib1Terminated1
DB12315Depatuxizumab mafodotin1Recruiting1
DB08809Dichloroacetic Acid1Completed1
DB08809Dichloroacetic Acid1Withdrawn1
DB00822Disulfiram1Recruiting1
DB00997Doxorubicin1Recruiting2
DB00530Erlotinib1Completed1
DB00773Etoposide1Completed1
DB00773Etoposide1Recruiting1
DB01590Everolimus1Completed1
DB01099Flucytosine1Active Not Recruiting1
DB01005Hydroxyurea1Completed2
DB00619Imatinib1Completed2
DB00724Imiquimod1Completed1
DB00724Imiquimod1Terminated1
DB06186Ipilimumab1Recruiting2
DB00762Irinotecan1Completed3
DB01167Itraconazole1Recruiting1
DB00134L-Methionine1Recruiting1
DB08932Macitentan1Completed1
DB08932Macitentan1Terminated1
DB11762Marizomib1Recruiting1
DB00643Mebendazole1Recruiting1
DB01017Minocycline1Recruiting1
DB00220Nelfinavir1Completed1
DB06132Nivolumab1Recruiting1
DB09035Nivolumab1Recruiting5
DB00019Pegfilgrastim1Completed1
DB05240Pilaralisib1Completed1
DB11772Pilaralisib1Completed1
DB11730Ribociclib1Recruiting1
DB00503Ritonavir1Recruiting1
DB00020Sargramostim1Active Not Recruiting1
DB00020Sargramostim1Completed1
DB01104Sertraline1Recruiting1
DB00877Sirolimus1Completed2
DB00398Sorafenib1Completed1
DB01268Sunitinib1Completed1
DB00853Temozolomide1Active Not Recruiting3
DB00853Temozolomide1Completed10
DB00853Temozolomide1Not Yet Recruiting1
DB00853Temozolomide1Recruiting8
DB00853Temozolomide1Terminated2
DB12077Urelumab1Recruiting1
DB00313Valproic Acid1Recruiting1
DB00313Valproic Acid1Withdrawn1
DB05294Vandetanib1Completed3
DB04879Vatalanib1Completed1
DB00126Vitamin C1Active Not Recruiting1
DB02546Vorinostat1Completed1
DB05241XL7651Completed1
DB05428motexafin gadolinium1Completed1
DB119196-O-benzylguanine1 / 2Active Not Recruiting1
DB00041Aldesleukin1 / 2Recruiting1
DB11595Atezolizumab1 / 2Recruiting1
DB00112Bevacizumab1 / 2Completed1
DB00112Bevacizumab1 / 2Recruiting1
DB00112Bevacizumab1 / 2Terminated1
DB00958Carboplatin1 / 2Recruiting1
DB00262Carmustine1 / 2Active Not Recruiting1
DB00531Cyclophosphamide1 / 2Recruiting1
DB11651Dactolisib1 / 2Enrolling by Invitation1
DB01254Dasatinib1 / 2Terminated1
DB12873Dianhydrogalactitol1 / 2Completed1
DB00997Doxorubicin1 / 2Completed1
DB11714Durvalumab1 / 2Recruiting1
DB11717Epacadostat1 / 2Recruiting1
DB01590Everolimus1 / 2Recruiting1
DB00099Filgrastim1 / 2Active Not Recruiting1
DB01073Fludarabine1 / 2Recruiting1
DB11911Galunisertib1 / 2Recruiting1
DB00762Irinotecan1 / 2Terminated1
DB00125L-Arginine1 / 2Recruiting1
DB01206Lomustine1 / 2Terminated1
DB11762Marizomib1 / 2Recruiting1
DB12155Napabucasin1 / 2Recruiting1
DB09035Nivolumab1 / 2Recruiting2
DB09037Pembrolizumab1 / 2Enrolling by Invitation1
DB12802Picropodophyllin1 / 2Unknown Status1
DB06809Plerixafor1 / 2Active Not Recruiting1
DB13017Rovalpituzumab Tesirine1 / 2Recruiting1
DB00398Sorafenib1 / 2Recruiting1
DB00853Temozolomide1 / 2Active Not Recruiting2
DB00853Temozolomide1 / 2Completed2
DB00853Temozolomide1 / 2Recruiting6
DB02546Vorinostat1 / 2Completed1
DB12001Abemaciclib2Recruiting1
DB00945Acetylsalicylic acid2Terminated1
DB00855Aminolevulinic acid2Active Not Recruiting1
DB00855Aminolevulinic acid2Completed1
DB00855Aminolevulinic acid2Terminated1
DB00855Aminolevulinic acid2Withdrawn1
DB11945Avelumab2Recruiting1
DB00074Basiliximab2Recruiting1
DB05136Bavituximab2Not Yet Recruiting1
DB00112Bevacizumab2Active Not Recruiting7
DB00112Bevacizumab2Completed16
DB00112Bevacizumab2Not Yet Recruiting1
DB00112Bevacizumab2Recruiting4
DB00112Bevacizumab2Withdrawn1
DB00188Bortezomib2Completed1
DB06616Bosutinib2Completed1
DB04849Cediranib2Terminated1
DB00002Cetuximab2Terminated1
DB00608Chloroquine2Not Yet Recruiting1
DB11890Cilengitide2Completed1
DB11890Cilengitide2Withdrawn1
DB00531Cyclophosphamide2Recruiting1
DB00260Cycloserine2Recruiting1
DB08912Dabrafenib2Not Yet Recruiting1
DB11963Dacomitinib2Active Not Recruiting2
DB01254Dasatinib2Withdrawn1
DB12315Depatuxizumab mafodotin2Recruiting1
DB12873Dianhydrogalactitol2Not Yet Recruiting1
DB12873Dianhydrogalactitol2Recruiting1
DB11714Durvalumab2Active Not Recruiting1
DB00530Erlotinib2Completed4
DB00773Etoposide2Completed2
DB11911Galunisertib2Active Not Recruiting1
DB00317Gefitinib2Completed1
DB00317Gefitinib2Terminated1
DB05036Grn163l2Completed1
DB01611Hydroxychloroquine2Active Not Recruiting1
DB01005Hydroxyurea2Completed1
DB00619Imatinib2Completed1
DB00619Imatinib2Terminated1
DB00762Irinotecan2Completed4
DB00160L-Alanine2Terminated1
DB00480Lenalidomide2Completed1
DB01206Lomustine2Active Not Recruiting1
DB01206Lomustine2Completed3
DB01206Lomustine2Not Yet Recruiting1
DB01601Lopinavir2Terminated1
DB05477MUC1 Dendritic Cell Vaccine2Completed1
DB01043Memantine2Terminated1
DB11813Mipsagargin2Withdrawn1
DB11828Neratinib2Recruiting1
DB13069Nimustine2Recruiting1
DB09079Nintedanib2Completed1
DB11746Onartuzumab2Completed1
DB11669Ortataxel2Suspended1
DB09073Palbociclib2Terminated1
DB06589Pazopanib2Not Yet Recruiting1
DB06589Pazopanib2Terminated1
DB09037Pembrolizumab2Active Not Recruiting1
DB09037Pembrolizumab2Not Yet Recruiting1
DB09037Pembrolizumab2Recruiting3
DB08901Ponatinib2Active Not Recruiting1
DB00503Ritonavir2Terminated1
DB05332Romiplostim2Recruiting1
DB05654Sagopilone2Completed1
DB00020Sargramostim2Recruiting2
DB11942Selinexor2Recruiting1
DB00203Sildenafil2Recruiting1
DB00877Sirolimus2Completed1
DB12601Sonolisib2Completed1
DB00398Sorafenib2Recruiting1
DB00398Sorafenib2Withdrawn1
DB01268Sunitinib2Completed2
DB05465Tandutinib2Completed1
DB00853Temozolomide2Active Not Recruiting2
DB00853Temozolomide2Completed16
DB00853Temozolomide2Not Yet Recruiting4
DB00853Temozolomide2Recruiting8
DB00853Temozolomide2Terminated2
DB00853Temozolomide2Unknown Status2
DB00853Temozolomide2Withdrawn2
DB06287Temsirolimus2Active Not Recruiting1
DB05007Tesevatinib2Recruiting1
DB11973Tesevatinib2Recruiting1
DB11800Tivozanib2Completed1
DB01030Topotecan2Not Yet Recruiting1
DB08911Trametinib2Not Yet Recruiting1
DB00313Valproic Acid2Recruiting1
DB05299keyhole limpet hemocyanin2Not Yet Recruiting1
DB00822Disulfiram2 / 3Recruiting1
DB00762Irinotecan2 / 3Unknown Status1
DB00134L-Methionine2 / 3Suspended1
DB01206Lomustine2 / 3Not Yet Recruiting1
DB01268Sunitinib2 / 3Not Yet Recruiting1
DB00853Temozolomide2 / 3Not Yet Recruiting1
DB00853Temozolomide2 / 3Suspended1
DB07232Veliparib2 / 3Suspended1
DB00855Aminolevulinic acid3Active Not Recruiting1
DB00112Bevacizumab3Active Not Recruiting1
DB00112Bevacizumab3Completed1
DB00112Bevacizumab3Recruiting1
DB00262Carmustine3Completed1
DB00262Carmustine3Terminated1
DB00262Carmustine3Unknown Status1
DB11890Cilengitide3Completed1
DB12873Dianhydrogalactitol3Recruiting1
DB04882Edotecarin3Completed1
DB00105Interferon Alfa-2b, Recombinant3Recruiting1
DB01206Lomustine3Completed3
DB01206Lomustine3Terminated1
DB05477MUC1 Dendritic Cell Vaccine3Active Not Recruiting1
DB05337SOT-1073Completed1
DB00853Temozolomide3Completed8
DB00853Temozolomide3Recruiting3
DB00853Temozolomide3Terminated1
DB00853Temozolomide4Completed1
DB00855Aminolevulinic acidNot AvailableRecruiting1
DB00112BevacizumabNot AvailableCompleted1
DB00112BevacizumabNot AvailableTerminated1
DB00262CarmustineNot AvailableUnknown Status1
DB12091GadoliniumNot AvailableWithdrawn1
DB11836SapanisertibNot AvailableRecruiting1
DB00853TemozolomideNot AvailableActive Not Recruiting1
DB00853TemozolomideNot AvailableCompleted4
DB00853TemozolomideNot AvailableTerminated1