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Identification
NameDezocine
Accession NumberDB01209  (APRD00912)
TypeSmall Molecule
GroupsApproved
DescriptionDezocine is a partial opiate drug and is used for pain management. Dezocine is a very effective alternative to fentanyl when administered during outpatient laparoscopy, although is associated with an increased incidence of postoperative nausea.
Structure
Thumb
Synonyms
(-)-13beta-amino-5,6,7,8,9,10,11alpha,12-Octahydro-5alpha-methyl-5,11-methanobenzocyclodecen-3-ol
Dezocina
Dezocinum
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
DalganNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNIIVHX8K5SV4X
CAS number53648-55-8
WeightAverage: 245.3599
Monoisotopic: 245.177964363
Chemical FormulaC16H23NO
InChI KeyVTMVHDZWSFQSQP-VBNZEHGJSA-N
InChI
InChI=1S/C16H23NO/c1-16-8-4-2-3-5-12(15(16)17)9-11-6-7-13(18)10-14(11)16/h6-7,10,12,15,18H,2-5,8-9,17H2,1H3/t12-,15-,16+/m0/s1
IUPAC Name
(1R,9S,15S)-15-amino-1-methyltricyclo[7.5.1.0²,⁷]pentadeca-2,4,6-trien-4-ol
SMILES
[H][C@@]12CC3=CC=C(O)C=C3[C@@](C)(CCCCC1)[[email protected]]2N
Pharmacology
IndicationIndicated in the treatment of moderate to severe pain.
Structured Indications Not Available
PharmacodynamicsDezocine is a parenteral narcotic analgesic possessing both agonist and antagonist activity. It is similar to morphine with respect to analgesic potency and onset and duration of action. The narcotic antagonist activity is greater than that of pentazocine.
Mechanism of actionDezocine is a opioid analgesic drug of mixed agonist-antagonist type. It binds with stereospecific receptors at many sites within the central nervous system (CNS) to alter processes affecting both the perception of pain and the emotional response to pain. At least 2 of these types of receptors (mu and kappa) mediate analgesia. Mu receptors are widely distributed throughout the CNS, especially in the limbic system (frontal cortex, temporal cortex, amygdala, and hippocampus), thalamus, striatum, hypothalamus, and midbrain as well as laminae I, II, IV, and V of the dorsal horn in the spinal cord. Kappa receptors are localized primarily in the spinal cord and in the cerebral cortex.
TargetKindPharmacological actionActionsOrganismUniProt ID
Mu-type opioid receptorProteinyes
agonist
HumanP35372 details
Kappa-type opioid receptorProteinyes
antagonist
HumanP41145 details
Related Articles
AbsorptionRapid and complete following intramuscular administration.
Volume of distributionNot Available
Protein bindingNot Available
Metabolism

Hepatic, via conjugation (glucuronidation).

Route of eliminationNot Available
Half lifeElimination half-life following intramuscular administration averages 2.2 hours. Elimination half-life following a 5mg intravenous dose averages 1.7 to 2.6 hours (range 0.6 to 4.4 hours) while a 10mg dose averages 2.4 to 2.6 hours (range 1.2 to 7.4 hours). In patients with hepatic cirrhosis, the half-life is increased by 30 to 50%.
ClearanceNot Available
ToxicitySymptoms of overdose include cold and clammy skin, confusion, nervousness, or severe restlessness, convulsions (seizures), severe dizziness, severe drowsiness, low blood pressure, pinpoint pupils of eyes, slow heartbeat, slow or troubled breathing and severe weakness.
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Dezocine Action PathwayDrug actionSMP00676
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
1,1,1,2 TetrafluoroethaneThe risk or severity of adverse effects can be increased when Dezocine is combined with 1,1,1,2 Tetrafluoroethane.Investigational
2,5-Dimethoxy-4-ethylamphetamine2,5-Dimethoxy-4-ethylamphetamine may increase the analgesic activities of Dezocine.Experimental, Illicit
3,4-Methylenedioxyamphetamine3,4-Methylenedioxyamphetamine may increase the analgesic activities of Dezocine.Experimental, Illicit
3,4-Methylenedioxymethamphetamine3,4-Methylenedioxymethamphetamine may increase the analgesic activities of Dezocine.Experimental, Illicit
4-Bromo-2,5-dimethoxyamphetamine4-Bromo-2,5-dimethoxyamphetamine may increase the analgesic activities of Dezocine.Experimental, Illicit
7-NitroindazoleThe risk or severity of adverse effects can be increased when Dezocine is combined with 7-Nitroindazole.Experimental
AcepromazineThe risk or severity of adverse effects can be increased when Dezocine is combined with Acepromazine.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Dezocine is combined with Aceprometazine.Approved
AcetazolamideThe risk or severity of adverse effects can be increased when Dezocine is combined with Acetazolamide.Approved, Vet Approved
AclidiniumThe risk or severity of adverse effects can be increased when Aclidinium is combined with Dezocine.Approved
adipiplonThe risk or severity of adverse effects can be increased when Dezocine is combined with adipiplon.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Dezocine is combined with Agomelatine.Approved, Investigational
AlfaxaloneThe risk or severity of adverse effects can be increased when Dezocine is combined with Alfaxalone.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Dezocine.Approved, Illicit
AlimemazineAlimemazine may increase the hypotensive activities of Dezocine.Approved, Vet Approved
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Dezocine is combined with Alphacetylmethadol.Experimental, Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Dezocine.Approved, Illicit, Investigational
AlvimopanThe risk or severity of adverse effects can be increased when Dezocine is combined with Alvimopan.Approved
AmilorideThe risk or severity of adverse effects can be increased when Dezocine is combined with Amiloride.Approved
AmisulprideThe risk or severity of adverse effects can be increased when Dezocine is combined with Amisulpride.Approved, Investigational
AmitriptylineThe risk or severity of adverse effects can be increased when Dezocine is combined with Amitriptyline.Approved
Ammonium chlorideAmmonium chloride may increase the excretion rate of Dezocine which could result in a lower serum level and potentially a reduction in efficacy.Approved, Vet Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Dezocine is combined with Amobarbital.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when Dezocine is combined with Amoxapine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Dezocine is combined with Amperozide.Experimental
AmphetamineAmphetamine may increase the analgesic activities of Dezocine.Approved, Illicit
Anisotropine MethylbromideThe risk or severity of adverse effects can be increased when Anisotropine Methylbromide is combined with Dezocine.Approved
AripiprazoleThe risk or severity of adverse effects can be increased when Dezocine is combined with Aripiprazole.Approved, Investigational
ArticaineThe risk or severity of adverse effects can be increased when Dezocine is combined with Articaine.Approved
AsenapineThe risk or severity of adverse effects can be increased when Dezocine is combined with Asenapine.Approved
Atracurium besylateThe risk or severity of adverse effects can be increased when Atracurium besylate is combined with Dezocine.Approved
AtropineThe risk or severity of adverse effects can be increased when Atropine is combined with Dezocine.Approved, Vet Approved
AzaperoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Azaperone.Vet Approved
AzelastineDezocine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
AzelastineThe risk or severity of adverse effects can be increased when Dezocine is combined with Azelastine.Approved
AzosemideThe risk or severity of adverse effects can be increased when Dezocine is combined with Azosemide.Investigational
BaclofenThe risk or severity of adverse effects can be increased when Dezocine is combined with Baclofen.Approved
BarbitalThe risk or severity of adverse effects can be increased when Dezocine is combined with Barbital.Illicit
BenactyzineThe risk or severity of adverse effects can be increased when Benactyzine is combined with Dezocine.Withdrawn
BendroflumethiazideThe risk or severity of adverse effects can be increased when Dezocine is combined with Bendroflumethiazide.Approved
BenperidolThe risk or severity of adverse effects can be increased when Dezocine is combined with Benperidol.Investigational
BenzatropineThe risk or severity of adverse effects can be increased when Benzatropine is combined with Dezocine.Approved
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Dezocine.Approved
BenzphetamineBenzphetamine may increase the analgesic activities of Dezocine.Approved, Illicit
Benzyl alcoholThe risk or severity of adverse effects can be increased when Dezocine is combined with Benzyl alcohol.Approved
BiperidenThe risk or severity of adverse effects can be increased when Biperiden is combined with Dezocine.Approved
BL-1020BL-1020 may increase the hypotensive activities of Dezocine.Investigational
BrexpiprazoleThe risk or severity of adverse effects can be increased when Dezocine is combined with Brexpiprazole.Approved
BrimonidineThe risk or severity of adverse effects can be increased when Dezocine is combined with Brimonidine.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Dezocine.Approved
BromazepamThe risk or severity of adverse effects can be increased when Dezocine is combined with Bromazepam.Approved, Illicit
BrompheniramineThe risk or severity of adverse effects can be increased when Dezocine is combined with Brompheniramine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Dezocine is combined with Brotizolam.Approved, Withdrawn
BumetanideThe risk or severity of adverse effects can be increased when Dezocine is combined with Bumetanide.Approved
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Dezocine.Approved, Investigational
BuprenorphineDezocine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Dezocine.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Dezocine.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Dezocine is combined with Butacaine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Dezocine is combined with Butalbital.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Dezocine is combined with Butamben.Approved
ButethalThe risk or severity of adverse effects can be increased when Dezocine is combined with Butethal.Approved, Illicit
ButorphanolButorphanol may decrease the analgesic activities of Dezocine.Approved, Illicit, Vet Approved
Canrenoic acidThe risk or severity of adverse effects can be increased when Dezocine is combined with Canrenoic acid.Approved, Withdrawn
CanrenoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Canrenone.Investigational
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Dezocine.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Dezocine is combined with Carbinoxamine.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Dezocine is combined with Carfentanil.Illicit, Vet Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Dezocine is combined with Carisoprodol.Approved
CetirizineThe risk or severity of adverse effects can be increased when Dezocine is combined with Cetirizine.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Dezocine is combined with Chloral hydrate.Approved, Illicit, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Dezocine.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Dezocine.Approved, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Dezocine.Approved
ChlorothiazideThe risk or severity of adverse effects can be increased when Dezocine is combined with Chlorothiazide.Approved, Vet Approved
ChlorphenamineThe risk or severity of adverse effects can be increased when Dezocine is combined with Chlorphenamine.Approved
ChlorphenoxamineThe risk or severity of adverse effects can be increased when Chlorphenoxamine is combined with Dezocine.Withdrawn
ChlorphentermineChlorphentermine may increase the analgesic activities of Dezocine.Illicit, Withdrawn
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Dezocine.Approved, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Dezocine is combined with Chlorprothixene.Approved, Withdrawn
ChlorthalidoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Chlorthalidone.Approved
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Chlorzoxazone.Approved
CicletanineThe risk or severity of adverse effects can be increased when Dezocine is combined with Cicletanine.Investigational
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Dezocine.Approved, Vet Approved
CitalopramDezocine may increase the serotonergic activities of Citalopram.Approved
ClemastineThe risk or severity of adverse effects can be increased when Dezocine is combined with Clemastine.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Dezocine is combined with Clidinium.Approved
ClobazamThe risk or severity of adverse effects can be increased when Dezocine is combined with Clobazam.Approved, Illicit
clomethiazoleThe risk or severity of adverse effects can be increased when Dezocine is combined with clomethiazole.Investigational
ClomipramineThe risk or severity of adverse effects can be increased when Dezocine is combined with Clomipramine.Approved, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Dezocine is combined with Clonazepam.Approved, Illicit
ClonidineThe risk or severity of adverse effects can be increased when Dezocine is combined with Clonidine.Approved
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Dezocine.Approved, Illicit
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Dezocine.Approved
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Dezocine.Approved, Illicit
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Dezocine.Approved, Illicit
ConivaptanThe risk or severity of adverse effects can be increased when Dezocine is combined with Conivaptan.Approved, Investigational
CyclizineThe risk or severity of adverse effects can be increased when Dezocine is combined with Cyclizine.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Dezocine.Approved
CyclopentolateThe risk or severity of adverse effects can be increased when Cyclopentolate is combined with Dezocine.Approved
CyclothiazideThe risk or severity of adverse effects can be increased when Dezocine is combined with Cyclothiazide.Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Dezocine is combined with Cyproheptadine.Approved
DantroleneThe risk or severity of adverse effects can be increased when Dezocine is combined with Dantrolene.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Dezocine.Approved
DapoxetineDezocine may increase the serotonergic activities of Dapoxetine.Investigational
DarifenacinThe risk or severity of adverse effects can be increased when Darifenacin is combined with Dezocine.Approved, Investigational
deramciclaneThe risk or severity of adverse effects can be increased when Dezocine is combined with deramciclane.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Dezocine.Approved
DesipramineThe risk or severity of adverse effects can be increased when Dezocine is combined with Desipramine.Approved
DesloratadineThe risk or severity of adverse effects can be increased when Dezocine is combined with Desloratadine.Approved, Investigational
DesmopressinThe risk or severity of adverse effects can be increased when Dezocine is combined with Desmopressin.Approved
DesvenlafaxineDezocine may increase the serotonergic activities of Desvenlafaxine.Approved
DetomidineThe risk or severity of adverse effects can be increased when Dezocine is combined with Detomidine.Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Dezocine is combined with Dexbrompheniramine.Approved
DexetimideThe risk or severity of adverse effects can be increased when Dexetimide is combined with Dezocine.Withdrawn
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Dezocine.Approved, Vet Approved
DextroamphetamineDextroamphetamine may increase the analgesic activities of Dezocine.Approved, Illicit
DextromoramideThe risk or severity of adverse effects can be increased when Dezocine is combined with Dextromoramide.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Dezocine.Approved, Illicit, Withdrawn
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Dezocine.Approved, Illicit, Vet Approved
DicyclomineThe risk or severity of adverse effects can be increased when Dicyclomine is combined with Dezocine.Approved
DiethylpropionDiethylpropion may increase the analgesic activities of Dezocine.Approved, Illicit
DifenoxinThe risk or severity of adverse effects can be increased when Dezocine is combined with Difenoxin.Approved, Illicit
DihydrocodeineThe risk or severity of adverse effects can be increased when Dezocine is combined with Dihydrocodeine.Approved, Illicit
DihydroetorphineThe risk or severity of adverse effects can be increased when Dezocine is combined with Dihydroetorphine.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Dezocine is combined with Dihydromorphine.Experimental, Illicit
DimenhydrinateThe risk or severity of adverse effects can be increased when Dezocine is combined with Dimenhydrinate.Approved
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Dezocine.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Dezocine.Approved, Illicit
DoramectinThe risk or severity of adverse effects can be increased when Dezocine is combined with Doramectin.Vet Approved
DoxepinThe risk or severity of adverse effects can be increased when Dezocine is combined with Doxepin.Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Dezocine.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when Dezocine is combined with DPDPE.Investigational
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Dezocine.Approved, Illicit
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Dezocine.Approved, Vet Approved
DrospirenoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Drospirenone.Approved
DrotebanolThe risk or severity of adverse effects can be increased when Dezocine is combined with Drotebanol.Experimental, Illicit
DuloxetineDezocine may increase the serotonergic activities of Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Dezocine.Approved
EcgonineThe risk or severity of adverse effects can be increased when Dezocine is combined with Ecgonine.Experimental, Illicit
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when Dezocine is combined with ECGONINE METHYL ESTER.Experimental
EcopipamThe risk or severity of adverse effects can be increased when Dezocine is combined with Ecopipam.Investigational
EfavirenzThe risk or severity of adverse effects can be increased when Dezocine is combined with Efavirenz.Approved, Investigational
EfonidipineThe risk or severity of adverse effects can be increased when Dezocine is combined with Efonidipine.Approved
EluxadolineDezocine may increase the constipating activities of Eluxadoline.Approved
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Dezocine.Approved, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Dezocine is combined with Entacapone.Approved, Investigational
EplerenoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Eplerenone.Approved
EscitalopramDezocine may increase the serotonergic activities of Escitalopram.Approved, Investigational
EstazolamThe risk or severity of adverse effects can be increased when Dezocine is combined with Estazolam.Approved, Illicit
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Dezocine.Approved
Etacrynic acidThe risk or severity of adverse effects can be increased when Dezocine is combined with Etacrynic acid.Approved
EthanolDezocine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Dezocine.Approved, Illicit, Withdrawn
EthopropazineThe risk or severity of adverse effects can be increased when Ethopropazine is combined with Dezocine.Approved
EthosuximideThe risk or severity of adverse effects can be increased when Dezocine is combined with Ethosuximide.Approved
EthotoinThe risk or severity of adverse effects can be increased when Dezocine is combined with Ethotoin.Approved
EthoxzolamideThe risk or severity of adverse effects can be increased when Dezocine is combined with Ethoxzolamide.Withdrawn
Ethyl carbamateThe risk or severity of adverse effects can be increased when Dezocine is combined with Ethyl carbamate.Withdrawn
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Dezocine is combined with Ethyl loflazepate.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Dezocine is combined with Ethylmorphine.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Dezocine is combined with Etidocaine.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Dezocine is combined with Etifoxine.Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Dezocine is combined with Etizolam.Approved
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Dezocine.Approved
EtoperidoneDezocine may increase the serotonergic activities of Etoperidone.Approved
EtorphineThe risk or severity of adverse effects can be increased when Dezocine is combined with Etorphine.Illicit, Vet Approved
EzogabineThe risk or severity of adverse effects can be increased when Dezocine is combined with Ezogabine.Approved
FelbamateThe risk or severity of adverse effects can be increased when Dezocine is combined with Felbamate.Approved
FencamfamineThe risk or severity of adverse effects can be increased when Dezocine is combined with Fencamfamine.Approved, Illicit, Withdrawn
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Dezocine.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe risk or severity of adverse effects can be increased when Fesoterodine is combined with Dezocine.Approved
FexofenadineThe risk or severity of adverse effects can be increased when Dezocine is combined with Fexofenadine.Approved
FlibanserinThe risk or severity of adverse effects can be increased when Dezocine is combined with Flibanserin.Approved
FludiazepamThe risk or severity of adverse effects can be increased when Dezocine is combined with Fludiazepam.Approved, Illicit
FlunarizineThe risk or severity of adverse effects can be increased when Dezocine is combined with Flunarizine.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Dezocine is combined with Flunitrazepam.Approved, Illicit
FluoxetineDezocine may increase the serotonergic activities of Fluoxetine.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Dezocine.Approved, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Dezocine.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Dezocine.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Dezocine is combined with Fluspirilene.Approved
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Dezocine is combined with Fluticasone Propionate.Approved
FluvoxamineThe risk or severity of adverse effects can be increased when Fluvoxamine is combined with Dezocine.Approved, Investigational
FosphenytoinThe risk or severity of adverse effects can be increased when Dezocine is combined with Fosphenytoin.Approved
FospropofolThe risk or severity of adverse effects can be increased when Dezocine is combined with Fospropofol.Approved, Illicit
FurosemideThe risk or severity of adverse effects can be increased when Dezocine is combined with Furosemide.Approved, Vet Approved
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Dezocine.Approved, Investigational
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Dezocine is combined with gabapentin enacarbil.Approved
Gallamine TriethiodideThe risk or severity of adverse effects can be increased when Gallamine Triethiodide is combined with Dezocine.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Dezocine is combined with Gamma Hydroxybutyric Acid.Approved, Illicit
GepironeThe risk or severity of adverse effects can be increased when Dezocine is combined with Gepirone.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Dezocine is combined with Glutethimide.Approved, Illicit
GlycopyrroniumThe risk or severity of adverse effects can be increased when Glycopyrronium is combined with Dezocine.Approved, Investigational, Vet Approved
GuanfacineThe risk or severity of adverse effects can be increased when Dezocine is combined with Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Dezocine.Approved, Illicit, Withdrawn
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Dezocine.Approved
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Dezocine.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Dezocine is combined with Heroin.Approved, Illicit
HexamethoniumThe risk or severity of adverse effects can be increased when Hexamethonium is combined with Dezocine.Experimental
HexobarbitalThe risk or severity of adverse effects can be increased when Dezocine is combined with Hexobarbital.Approved
HomatropineThe risk or severity of adverse effects can be increased when Homatropine is combined with Dezocine.Approved
HydrochlorothiazideThe risk or severity of adverse effects can be increased when Dezocine is combined with Hydrochlorothiazide.Approved, Vet Approved
HydrocodoneDezocine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydroflumethiazideThe risk or severity of adverse effects can be increased when Dezocine is combined with Hydroflumethiazide.Approved
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Dezocine.Approved, Illicit
Hydroxyamphetamine hydrobromideHydroxyamphetamine hydrobromide may increase the analgesic activities of Dezocine.Approved
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Dezocine.Approved
HyoscyamineThe risk or severity of adverse effects can be increased when Hyoscyamine is combined with Dezocine.Approved
IloperidoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Iloperidone.Approved
ImipramineThe risk or severity of adverse effects can be increased when Dezocine is combined with Imipramine.Approved
IndalpineDezocine may increase the serotonergic activities of Indalpine.Investigational, Withdrawn
IndapamideThe risk or severity of adverse effects can be increased when Dezocine is combined with Indapamide.Approved
Ipratropium bromideThe risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Dezocine.Approved
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Dezocine.Approved, Vet Approved
IsosorbideThe risk or severity of adverse effects can be increased when Dezocine is combined with Isosorbide.Approved
KetamineThe risk or severity of adverse effects can be increased when Dezocine is combined with Ketamine.Approved, Vet Approved
KetazolamThe risk or severity of adverse effects can be increased when Dezocine is combined with Ketazolam.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Ketobemidone.Approved
KW-3902The risk or severity of adverse effects can be increased when Dezocine is combined with KW-3902.Investigational
LamotrigineThe risk or severity of adverse effects can be increased when Dezocine is combined with Lamotrigine.Approved, Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Dezocine is combined with Levetiracetam.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Dezocine.Approved
LevocabastineThe risk or severity of adverse effects can be increased when Dezocine is combined with Levocabastine.Approved
LevocetirizineThe risk or severity of adverse effects can be increased when Dezocine is combined with Levocetirizine.Approved
LevodopaThe risk or severity of adverse effects can be increased when Dezocine is combined with Levodopa.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Dezocine is combined with Levomethadyl Acetate.Approved
LevomilnacipranDezocine may increase the serotonergic activities of Levomilnacipran.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Dezocine.Approved
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Dezocine.Approved, Vet Approved
LisdexamfetamineLisdexamfetamine may increase the analgesic activities of Dezocine.Approved, Investigational
LithiumThe risk or severity of adverse effects can be increased when Dezocine is combined with Lithium.Approved
LofentanilThe risk or severity of adverse effects can be increased when Dezocine is combined with Lofentanil.Illicit
LoratadineThe risk or severity of adverse effects can be increased when Dezocine is combined with Loratadine.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Dezocine.Approved
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Dezocine.Approved
Lu AA21004The risk or severity of adverse effects can be increased when Dezocine is combined with Lu AA21004.Investigational
LurasidoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Lurasidone.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Dezocine.Approved, Vet Approved
MannitolThe risk or severity of adverse effects can be increased when Dezocine is combined with Mannitol.Approved, Investigational
MaprotilineThe risk or severity of adverse effects can be increased when Dezocine is combined with Maprotiline.Approved
MecamylamineThe risk or severity of adverse effects can be increased when Mecamylamine is combined with Dezocine.Approved
MeclizineThe risk or severity of adverse effects can be increased when Dezocine is combined with Meclizine.Approved
MedetomidineThe risk or severity of adverse effects can be increased when Dezocine is combined with Medetomidine.Vet Approved
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Dezocine.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Melperone.Approved
MephedroneMephedrone may increase the analgesic activities of Dezocine.Investigational
MephentermineMephentermine may increase the analgesic activities of Dezocine.Approved
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Dezocine.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Dezocine.Approved, Illicit
MersalylThe risk or severity of adverse effects can be increased when Dezocine is combined with Mersalyl.Approved
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Dezocine.Approved
MetaxaloneThe risk or severity of adverse effects can be increased when Dezocine is combined with Metaxalone.Approved
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Dezocine.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Dezocine is combined with Methadyl Acetate.Approved, Illicit
MethamphetamineMethamphetamine may increase the analgesic activities of Dezocine.Approved, Illicit
MethanthelineThe risk or severity of adverse effects can be increased when Methantheline is combined with Dezocine.Approved
MethapyrileneThe risk or severity of adverse effects can be increased when Dezocine is combined with Methapyrilene.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Methaqualone.Illicit, Withdrawn
MethazolamideThe risk or severity of adverse effects can be increased when Dezocine is combined with Methazolamide.Approved
MethocarbamolThe risk or severity of adverse effects can be increased when Dezocine is combined with Methocarbamol.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Dezocine.Approved
MethotrimeprazineDezocine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Dezocine.Approved, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Dezocine is combined with Methsuximide.Approved
MethyclothiazideThe risk or severity of adverse effects can be increased when Dezocine is combined with Methyclothiazide.Approved
Methylene blueMethylene blue may increase the hypotensive activities of Dezocine.Investigational
MethylnaltrexoneThe risk or severity of adverse effects can be increased when Methylnaltrexone is combined with Dezocine.Approved
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Dezocine.Approved
MetixeneThe risk or severity of adverse effects can be increased when Metixene is combined with Dezocine.Approved
MetolazoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Metolazone.Approved
MetyrosineDezocine may increase the sedative activities of Metyrosine.Approved
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Dezocine.Approved, Illicit
MilnacipranDezocine may increase the serotonergic activities of Milnacipran.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Dezocine.Approved, Investigational
MirtazapineDezocine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MMDAMMDA may increase the analgesic activities of Dezocine.Experimental, Illicit
MolindoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Molindone.Approved
MoricizineMoricizine may increase the hypotensive activities of Dezocine.Approved, Withdrawn
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Dezocine.Approved, Investigational
N-butylscopolammonium bromideThe risk or severity of adverse effects can be increased when N-butylscopolammonium bromide is combined with Dezocine.Vet Approved
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Dezocine.Approved, Investigational
NalbuphineNalbuphine may decrease the analgesic activities of Dezocine.Approved
NaloxegolThe risk or severity of adverse effects can be increased when Dezocine is combined with Naloxegol.Approved
NaltrexoneThe therapeutic efficacy of Dezocine can be decreased when used in combination with Naltrexone.Approved, Investigational, Vet Approved
NefazodoneDezocine may increase the serotonergic activities of Nefazodone.Approved, Withdrawn
NitrazepamThe risk or severity of adverse effects can be increased when Dezocine is combined with Nitrazepam.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Dezocine is combined with Nitrous oxide.Approved, Vet Approved
NormethadoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Normethadone.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Dezocine is combined with Nortriptyline.Approved
NVA237The risk or severity of adverse effects can be increased when NVA237 is combined with Dezocine.Investigational
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Dezocine.Approved, Investigational
OlopatadineThe risk or severity of adverse effects can be increased when Dezocine is combined with Olopatadine.Approved
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Dezocine.Approved
OpiumThe risk or severity of adverse effects can be increased when Dezocine is combined with Opium.Approved, Illicit
OrphenadrineDezocine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Dezocine is combined with Osanetant.Investigational
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Dezocine.Approved
OxetacaineThe risk or severity of adverse effects can be increased when Dezocine is combined with Oxetacaine.Investigational
OxprenololThe risk or severity of adverse effects can be increased when Dezocine is combined with Oxprenolol.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Dezocine.Approved
OxybutyninThe risk or severity of adverse effects can be increased when Oxybutynin is combined with Dezocine.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Dezocine.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Dezocine.Approved, Investigational, Vet Approved
OxyphenoniumThe risk or severity of adverse effects can be increased when Oxyphenonium is combined with Dezocine.Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Paliperidone.Approved
PancuroniumThe risk or severity of adverse effects can be increased when Pancuronium is combined with Dezocine.Approved
ParaldehydeDezocine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ParoxetineDezocine may increase the serotonergic activities of Paroxetine.Approved, Investigational
PegvisomantThe therapeutic efficacy of Pegvisomant can be decreased when used in combination with Dezocine.Approved
PentazocinePentazocine may decrease the analgesic activities of Dezocine.Approved, Vet Approved
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Dezocine.Approved, Vet Approved
PentoliniumThe risk or severity of adverse effects can be increased when Pentolinium is combined with Dezocine.Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Dezocine.Approved
PerazineThe risk or severity of adverse effects can be increased when Dezocine is combined with Perazine.Investigational
PerospironeThe risk or severity of adverse effects can be increased when Dezocine is combined with Perospirone.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Dezocine.Approved
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Dezocine.Approved
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Dezocine.Approved
PhenoxyethanolThe risk or severity of adverse effects can be increased when Dezocine is combined with Phenoxyethanol.Approved
PhenterminePhentermine may increase the analgesic activities of Dezocine.Approved, Illicit
PhenytoinThe risk or severity of adverse effects can be increased when Dezocine is combined with Phenytoin.Approved, Vet Approved
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Dezocine.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Pipamperone.Approved
PipecuroniumThe risk or severity of adverse effects can be increased when Pipecuronium is combined with Dezocine.Approved
PipotiazineThe risk or severity of adverse effects can be increased when Dezocine is combined with Pipotiazine.Approved
PirenzepineThe risk or severity of adverse effects can be increased when Pirenzepine is combined with Dezocine.Approved
PiretanideThe risk or severity of adverse effects can be increased when Dezocine is combined with Piretanide.Experimental
PiritramideThe risk or severity of adverse effects can be increased when Dezocine is combined with Piritramide.Investigational
PizotifenThe risk or severity of adverse effects can be increased when Dezocine is combined with Pizotifen.Approved
PolythiazideThe risk or severity of adverse effects can be increased when Dezocine is combined with Polythiazide.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Dezocine is combined with Pomalidomide.Approved
PotassiumThe risk or severity of adverse effects can be increased when Dezocine is combined with Potassium.Approved
Potassium CitrateThe risk or severity of adverse effects can be increased when Dezocine is combined with Potassium Citrate.Approved, Vet Approved
PramipexoleDezocine may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Dezocine is combined with Pramocaine.Approved
PrazepamThe risk or severity of adverse effects can be increased when Dezocine is combined with Prazepam.Approved, Illicit
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Dezocine.Approved, Illicit, Investigational
PregnanoloneThe risk or severity of adverse effects can be increased when Dezocine is combined with Pregnanolone.Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Dezocine.Approved
PrimidoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Primidone.Approved, Vet Approved
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Dezocine.Approved, Investigational, Vet Approved
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Dezocine.Approved, Vet Approved
ProcyclidineThe risk or severity of adverse effects can be increased when Procyclidine is combined with Dezocine.Approved
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Dezocine.Approved, Vet Approved
PromethazineThe risk or severity of adverse effects can be increased when Dezocine is combined with Promethazine.Approved
PropanthelineThe risk or severity of adverse effects can be increased when Propantheline is combined with Dezocine.Approved
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Dezocine.Approved, Vet Approved
PropiopromazinePropiopromazine may increase the hypotensive activities of Dezocine.Vet Approved
PropiverineThe risk or severity of adverse effects can be increased when Propiverine is combined with Dezocine.Investigational
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Dezocine.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Dezocine is combined with Propoxycaine.Approved
ProtriptylineThe risk or severity of adverse effects can be increased when Dezocine is combined with Protriptyline.Approved
PSD502The risk or severity of adverse effects can be increased when Dezocine is combined with PSD502.Investigational
PseudoephedrinePseudoephedrine may increase the analgesic activities of Dezocine.Approved
QuazepamThe risk or severity of adverse effects can be increased when Dezocine is combined with Quazepam.Approved, Illicit
QuetiapineThe risk or severity of adverse effects can be increased when Dezocine is combined with Quetiapine.Approved
QuinethazoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Quinethazone.Approved
QuinidineThe risk or severity of adverse effects can be increased when Quinidine is combined with Dezocine.Approved
RacloprideThe risk or severity of adverse effects can be increased when Dezocine is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Dezocine is combined with Ramelteon.Approved, Investigational
RamosetronDezocine may increase the constipating activities of Ramosetron.Approved
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Dezocine.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Dezocine.Approved, Withdrawn
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Dezocine.Approved
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Dezocine.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Dezocine is combined with Ritanserin.Investigational
RitobegronRitobegron may increase the analgesic activities of Dezocine.Investigational
RolofyllineThe risk or severity of adverse effects can be increased when Dezocine is combined with Rolofylline.Investigational
RomifidineThe risk or severity of adverse effects can be increased when Dezocine is combined with Romifidine.Vet Approved
RopiniroleDezocine may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Dezocine.Approved
RotigotineDezocine may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Dezocine.Approved
S-EthylisothioureaThe risk or severity of adverse effects can be increased when Dezocine is combined with S-Ethylisothiourea.Experimental
Sage 547The risk or severity of adverse effects can be increased when Dezocine is combined with Sage 547.Investigational
ScopolamineThe risk or severity of adverse effects can be increased when Dezocine is combined with Scopolamine.Approved
Scopolamine butylbromideThe risk or severity of adverse effects can be increased when Scopolamine butylbromide is combined with Dezocine.Approved
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Dezocine.Approved, Vet Approved
SertindoleThe risk or severity of adverse effects can be increased when Dezocine is combined with Sertindole.Approved, Withdrawn
SertralineDezocine may increase the serotonergic activities of Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Dezocine is combined with Sevoflurane.Approved, Vet Approved
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Dezocine.Approved
SolifenacinThe risk or severity of adverse effects can be increased when Solifenacin is combined with Dezocine.Approved
SpironolactoneThe risk or severity of adverse effects can be increased when Dezocine is combined with Spironolactone.Approved
StiripentolThe risk or severity of adverse effects can be increased when Dezocine is combined with Stiripentol.Approved
SuccinylcholineSuccinylcholine may increase the bradycardic activities of Dezocine.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Dezocine.Approved, Investigational
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Dezocine.Approved
SuvorexantDezocine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TandospironeThe risk or severity of adverse effects can be increased when Dezocine is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Dezocine.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Dezocine is combined with Tasimelteon.Approved
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Dezocine.Approved
TetrabenazineThe risk or severity of adverse effects can be increased when Dezocine is combined with Tetrabenazine.Approved
TetracaineThe risk or severity of adverse effects can be increased when Dezocine is combined with Tetracaine.Approved, Vet Approved
TetrodotoxinThe risk or severity of adverse effects can be increased when Dezocine is combined with Tetrodotoxin.Investigational
ThalidomideDezocine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
TheobromineThe risk or severity of adverse effects can be increased when Dezocine is combined with Theobromine.Approved
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Dezocine.Approved, Vet Approved
ThiethylperazineThiethylperazine may increase the hypotensive activities of Dezocine.Withdrawn
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Dezocine.Approved, Vet Approved
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Dezocine.Approved
ThiothixeneThe risk or severity of adverse effects can be increased when Dezocine is combined with Thiothixene.Approved
TiagabineThe risk or severity of adverse effects can be increased when Dezocine is combined with Tiagabine.Approved
TiaprideThe risk or severity of adverse effects can be increased when Dezocine is combined with Tiapride.Investigational
TicrynafenThe risk or severity of adverse effects can be increased when Dezocine is combined with Ticrynafen.Withdrawn
TiletamineThe risk or severity of adverse effects can be increased when Dezocine is combined with Tiletamine.Vet Approved
TiotropiumThe risk or severity of adverse effects can be increased when Tiotropium is combined with Dezocine.Approved
TizanidineThe risk or severity of adverse effects can be increased when Dezocine is combined with Tizanidine.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Dezocine is combined with Tolcapone.Approved, Withdrawn
TolterodineThe risk or severity of adverse effects can be increased when Tolterodine is combined with Dezocine.Approved, Investigational
TolvaptanThe risk or severity of adverse effects can be increased when Dezocine is combined with Tolvaptan.Approved
TopiramateThe risk or severity of adverse effects can be increased when Dezocine is combined with Topiramate.Approved
TorasemideThe risk or severity of adverse effects can be increased when Dezocine is combined with Torasemide.Approved
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Dezocine.Approved, Investigational
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Dezocine is combined with Trans-2-Phenylcyclopropylamine.Experimental
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Dezocine.Approved
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with Dezocine.Approved, Investigational
TriamtereneThe risk or severity of adverse effects can be increased when Dezocine is combined with Triamterene.Approved
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Dezocine.Approved
TrichlormethiazideThe risk or severity of adverse effects can be increased when Dezocine is combined with Trichlormethiazide.Approved, Vet Approved
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Dezocine.Approved
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Dezocine.Approved, Vet Approved
TrihexyphenidylThe risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Dezocine.Approved
TrimethaphanThe risk or severity of adverse effects can be increased when Trimethaphan is combined with Dezocine.Approved
TrimipramineThe risk or severity of adverse effects can be increased when Dezocine is combined with Trimipramine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Dezocine is combined with Triprolidine.Approved
TropicamideThe risk or severity of adverse effects can be increased when Tropicamide is combined with Dezocine.Approved
TrospiumThe risk or severity of adverse effects can be increased when Trospium is combined with Dezocine.Approved
TubocurarineThe risk or severity of adverse effects can be increased when Tubocurarine is combined with Dezocine.Approved
Uc1010The risk or severity of adverse effects can be increased when Dezocine is combined with Uc1010.Investigational
UlaritideThe risk or severity of adverse effects can be increased when Dezocine is combined with Ularitide.Investigational
UmeclidiniumThe risk or severity of adverse effects can be increased when Umeclidinium is combined with Dezocine.Approved
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Dezocine.Approved, Investigational
VecuroniumThe risk or severity of adverse effects can be increased when Vecuronium is combined with Dezocine.Approved
VenlafaxineDezocine may increase the serotonergic activities of Venlafaxine.Approved
VigabatrinThe risk or severity of adverse effects can be increased when Dezocine is combined with Vigabatrin.Approved
VortioxetineThe risk or severity of adverse effects can be increased when Dezocine is combined with Vortioxetine.Approved
XylazineThe risk or severity of adverse effects can be increased when Dezocine is combined with Xylazine.Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Dezocine.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Dezocine is combined with Ziconotide.Approved
ZimelidineDezocine may increase the serotonergic activities of Zimelidine.Withdrawn
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Dezocine.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Dezocine is combined with Zolazepam.Vet Approved
ZolpidemDezocine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Dezocine is combined with Zonisamide.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Dezocine.Approved
ZotepineThe risk or severity of adverse effects can be increased when Dezocine is combined with Zotepine.Approved
ZuclopenthixolThe risk or severity of adverse effects can be increased when Dezocine is combined with Zuclopenthixol.Approved, Investigational
Food InteractionsNot Available
References
Synthesis ReferenceNot Available
General ReferencesNot Available
External Links
ATC CodesN02AX03
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9932
Blood Brain Barrier+0.9403
Caco-2 permeable+0.6275
P-glycoprotein substrateSubstrate0.6181
P-glycoprotein inhibitor INon-inhibitor0.9556
P-glycoprotein inhibitor IINon-inhibitor0.8905
Renal organic cation transporterNon-inhibitor0.7672
CYP450 2C9 substrateNon-substrate0.7337
CYP450 2D6 substrateNon-substrate0.6473
CYP450 3A4 substrateSubstrate0.5845
CYP450 1A2 substrateInhibitor0.5521
CYP450 2C9 inhibitorNon-inhibitor0.7985
CYP450 2D6 inhibitorNon-inhibitor0.8933
CYP450 2C19 inhibitorNon-inhibitor0.7939
CYP450 3A4 inhibitorNon-inhibitor0.7701
CYP450 inhibitory promiscuityHigh CYP Inhibitory Promiscuity0.5
Ames testNon AMES toxic0.7561
CarcinogenicityNon-carcinogens0.8934
BiodegradationNot ready biodegradable0.9865
Rat acute toxicity2.4549 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.8997
hERG inhibition (predictor II)Inhibitor0.6053
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
logP3.3Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.014 mg/mLALOGPS
logP3.77ALOGPS
logP3.23ChemAxon
logS-4.2ALOGPS
pKa (Strongest Acidic)10.43ChemAxon
pKa (Strongest Basic)9.67ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area46.25 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity74.19 m3·mol-1ChemAxon
Polarizability28.49 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as tetralins. These are polycyclic aromatic compounds containing a tetralin moiety, which consists of a benzene fused to a cyclohexane.
KingdomOrganic compounds
Super ClassBenzenoids
ClassTetralins
Sub ClassNot Available
Direct ParentTetralins
Alternative Parents
Substituents
  • Tetralin
  • Aralkylamine
  • Hydrocarbon derivative
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Primary aliphatic amine
  • Amine
  • Aromatic homopolycyclic compound
Molecular FrameworkAromatic homopolycyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Voltage-gated calcium channel activity
Specific Function:
Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociati...
Gene Name:
OPRM1
Uniprot ID:
P35372
Molecular Weight:
44778.855 Da
References
  1. Picker MJ: Discriminative stimulus effects of the mixed-opioid agonist/antagonist dezocine: cross-substitution by mu and delta opioid agonists. J Pharmacol Exp Ther. 1997 Dec;283(3):1009-17. [PubMed:9399970 ]
  2. Barrett AC, Cook CD, Terner JM, Craft RM, Picker MJ: Importance of sex and relative efficacy at the mu opioid receptor in the development of tolerance and cross-tolerance to the antinociceptive effects of opioids. Psychopharmacology (Berl). 2001 Nov;158(2):154-64. [PubMed:11702089 ]
  3. Cook CD, Barrett AC, Roach EL, Bowman JR, Picker MJ: Sex-related differences in the antinociceptive effects of opioids: importance of rat genotype, nociceptive stimulus intensity, and efficacy at the mu opioid receptor. Psychopharmacology (Berl). 2000 Jul;150(4):430-42. [PubMed:10958085 ]
  4. Gharagozlou P, Demirci H, David Clark J, Lameh J: Activity of opioid ligands in cells expressing cloned mu opioid receptors. BMC Pharmacol. 2003 Jan 4;3:1. Epub 2003 Jan 4. [PubMed:12513698 ]
  5. Morgan D, Cook CD, Smith MA, Picker MJ: An examination of the interactions between the antinociceptive effects of morphine and various mu-opioids: the role of intrinsic efficacy and stimulus intensity. Anesth Analg. 1999 Feb;88(2):407-13. [PubMed:9972766 ]
  6. Jacobs AM, Youngblood F: Opioid receptor affinity for agonist-antagonist analgesics. J Am Podiatr Med Assoc. 1992 Oct;82(10):520-4. [PubMed:1361946 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
antagonist
General Function:
Opioid receptor activity
Specific Function:
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates th...
Gene Name:
OPRK1
Uniprot ID:
P41145
Molecular Weight:
42644.665 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Gharagozlou P, Hashemi E, DeLorey TM, Clark JD, Lameh J: Pharmacological profiles of opioid ligands at kappa opioid receptors. BMC Pharmacol. 2006 Jan 25;6:3. [PubMed:16433932 ]
  4. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23