Naphthalenes

Two-ring crystalline hydrocarbons isolated from coal tar. They are used as intermediates in chemical synthesis, as insect repellents, fungicides, lubricants, preservatives, and, formerly, as topical antiseptics.
DrugDrug NameDrug Indication
DB00170MenadioneThe primary known function of vitamin K is to assist in the normal clotting of blood, but it may also play a role in normal bone calcification.
DB00210AdapaleneFor the topical treatment of comedo, papular and pustular acne (acne vulgaris) of the face, chest or back.
DB00307BexaroteneUsed orally for the treatment of skin manifestations of cutaneous T-cell lymphoma (CTCL) in patients who are refractory to at least one prior systemic therapy. Also used topically for the treatment of skin lesions in early (stage IA and IB) CTCL in patients who experience refractory or persistent disease with the use of other therapies or are intolerant of other therapies.
DB00525TolnaftateTolnaftate topical is used to treat skin infections such as athlete's foot, jock itch, and ringworm infections. Tolnaftate is also used, along with other antifungals, to treat infections of the nails, scalp, palms, and soles of the feet. The powder and powder aerosol may be used to prevent athlete's foot.
DB00571PropranololPropranolol is indicated to treat hypertension.[L6907,L6904] Propranolol is also indicated to treat angina pectoris due to coronary atherosclerosis, atrial fibrillation, myocardial infarction, migraine, essential tremor, hypertrophic subaortic stenosis, pheochromocytoma, and proliferating infantile hemangioma.[L6904,L6907]
DB00641SimvastatinFor the treatment of hypercholesterolemia and for the reduction in the risk of cardiac heart disease mortality and cardiovascular events. It can also be used in adolescent patients for the treatment of heterozygous familial hypercholesterolemia.
DB00773EtoposideFor use in combination with other chemotherapeutic agents in the treatment of refractory testicular tumors and as first line treatment in patients with small cell lung cancer. Also used to treat other malignancies such as lymphoma, non-lymphocytic leukemia, and glioblastoma multiforme.
DB00788NaproxenNaproxen is indicated for the management of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendinitis, bursitis, acute gout, primary dysmenorrhea, and for the relief of mild to moderate pain.[L6582][L6583][A178975] Further, it is first-line therapy for osteoarthritis, acute gouty arthritis, dysmenorrhea, and musculoskeletal inflammation and pain.[A178975]
DB01012CinacalcetFor the treatment of secondary hyperparathyroidism in patients with Chronic Kidney Disease who are on hemodialysis or peritoneal dialysis. Also for the treatment of hypercalcemia in patients with parathyroid carcinoma.
DB01022PhylloquinoneFor the treatment of haemorrhagic conditions in infants, antidote for coumarin anticoagulants in hypoprothrombinaemia.
DB01104SertralineFor the management of major depressive disorder (MDD), posttraumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), panic disorder (PD) with or without agoraphobia, premenstrual dysphoric disorder (PMDD), and social anxiety disorder (SAD) [FDA Label]. It may be used for premature ejaculation and vascular headaches as off-label indications.
DB01117AtovaquoneFor the treatment or prevention of Pneumocystis carinii pneumonia in patients who are intolerant to trimethoprim-sulfamethoxazole (TMP-SMX). Also indicated for the acute oral treatment of mild to moderate PCP in patients who are intolerant to TMP-SMX.
DB01179PodofiloxFor treatment of external genital warts (Condyloma acuminatum).
DB01209DezocineIndicated in the treatment of moderate to severe pain.
DB01210LevobunololFor lowering intraocular pressure (IOP) and may be used in patients with chronic open-angle glaucoma or ocular hypertension.
DB01388MibefradilFor the treatment of angina and high blood pressure.
DB01668Nanaomycin DNot Available
DB02866DansylamideNot Available
DB03157N,O-Didansyl-L-TyrosineNot Available
DB04640Naphthalene-2,6-disulfonic acidNot Available
DB04744LawsoneNot Available
DB04786SuraminFor treatment of human sleeping sickness, onchocerciasis and other diseases caused by trypanosomes and worms.
DB04942TamibaroteneInvestigated for use/treatment in leukemia (unspecified).
DB05022AmonafideInvestigated for use/treatment in breast cancer, ovarian cancer, and prostate cancer.
DB05271RotigotineFor use/treatment in neurologic disorders and parkinson's disease as well as moderate-to-severe primary Restless Legs Syndrome.
DB05385PRO 2000Investigated for use/treatment in HIV prevention, prevention of stdis, and vaginal infection.
DB05395AmibegronInvestigated for use/treatment in depression, irritable bowel syndrome (IBS), and obesity.
DB06202LasofoxifeneInvestigated for use/treatment in postmenopausal osteoporosis to reduce the risk of both vertebral and novertebral fractures, as well as address other postmenopausal conditions, including reduction in risk of breast cancer and treatment of vulvar and vaginal atrophy (VVA)
DB06682NaproxcinodInvestigated for use/treatment in pain (acute or chronic), inflammatory disorders (unspecified), osteoarthritis, and arthritis and arthritic pain.
DB06693MevastatinNot used therapeutically due to its many side effects.
DB06740BW-A 58CNot Available
DB068753-(3-FLUORO-4-HYDROXYPHENYL)-7-HYDROXY-1-NAPHTHONITRILENot Available
DB076692,3-DIMETHYL-1,4-NAPHTHOQUINONENot Available
DB082542-NAPHTHALENESULFONIC ACIDNot Available
DB09158Trypan blue free acidTrypan blue is indicated for use as an aid in ophthalmic surgery by staining the epiretinal membranes during ophthalmic surgical vitrectomy procedures, facilitating removal of the tissue.
DB11267TriethoxycaprylylsilaneNot Available
DB11806VTP-194204Not Available
DB12005NirogacestatNot Available
DB12148MenatetrenoneNot Available
DB12220ORG-25935Not Available
DB12305DasotralineNot Available
DB12467TU-100Not Available
DB12802PicropodophyllinNot Available
DB13075Menaquinone 7Not Available
DB13652BunaftineNot Available
DB13680NaftazoneNot Available
DB14071DesmethylsertralineNot Available
DB14636Triciribine phosphateNot Available
DB14650Menadiol diphosphateNot Available
DB017501-naphthaleneacetic acidNot Available
DB019416-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)Cyclopropyl]Pyridine-3-Carboxylic AcidNot Available
DB03322DexpropranololNot Available
DB11948LapachoneNot Available
DB14936Menaquinone 6Not Available
DB15377ATB-346Not Available
DB15381MenaquinoneNot Available
DrugDrug NameTargetType
DB00170MenadioneVitamin K-dependent protein Ztarget
DB00170MenadioneProthrombintarget
DB00170MenadioneVitamin K epoxide reductase complex subunit 1target
DB00170MenadioneCoagulation factor IXtarget
DB00170MenadioneCoagulation factor VIItarget
DB00170MenadioneCoagulation factor Xtarget
DB00170MenadioneVitamin K-dependent gamma-carboxylasetarget
DB00170MenadioneVitamin K-dependent protein Ctarget
DB00170MenadioneVitamin K-dependent protein Starget
DB00170MenadioneNAD(P)H dehydrogenase [quinone] 1target
DB00170MenadioneRibosyldihydronicotinamide dehydrogenase [quinone]target
DB00170MenadioneVitamin K epoxide reductase complex subunit 1-like protein 1target
DB00170MenadioneXanthine dehydrogenase/oxidaseenzyme
DB00170MenadioneAldehyde oxidaseenzyme
DB00170MenadioneMethylenetetrahydrofolate reductaseenzyme
DB00170MenadioneCytochrome P450 2E1enzyme
DB00170MenadioneCytochrome P450 1A1enzyme
DB00170MenadioneOsteocalcintarget
DB00170MenadioneCytochrome P450 1A2enzyme
DB00170MenadioneCytochrome P450 2A6enzyme
DB00210AdapaleneRetinoic acid receptor alphatarget
DB00210AdapaleneRetinoic acid receptor RXR-betatarget
DB00210AdapaleneRetinoic acid receptor gammatarget
DB00210AdapaleneRetinoic acid receptor betatarget
DB00210AdapaleneRetinoic acid receptor RXR-gammatarget
DB00210AdapaleneRetinoic acid receptor RXR-alphatarget
DB00210AdapaleneProstaglandin G/H synthase 2target
DB00307BexaroteneRetinoic acid receptor RXR-betatarget
DB00307BexaroteneCytochrome P450 3A4enzyme
DB00307BexaroteneRetinoic acid receptor RXR-alphatarget
DB00307BexaroteneRetinoic acid receptor RXR-gammatarget
DB00307BexaroteneCytochrome P450 2C9enzyme
DB00307BexaroteneCytochrome P450 2C8enzyme
DB00525TolnaftateSqualene monooxygenasetarget
DB00571PropranololBeta-1 adrenergic receptortarget
DB00571PropranololBeta-2 adrenergic receptortarget
DB00571PropranololBeta-3 adrenergic receptortarget
DB00571Propranolol5-hydroxytryptamine receptor 1Atarget
DB00571Propranolol5-hydroxytryptamine receptor 1Btarget
DB00571PropranololCytochrome P450 1A2enzyme
DB00571PropranololCytochrome P450 2D6enzyme
DB00571PropranololAlpha-1-acid glycoprotein 1carrier
DB00571PropranololCytochrome P450 2C19enzyme
DB00571PropranololCytochrome P450 3A4enzyme
DB00571PropranololCytochrome P450 3A5enzyme
DB00571PropranololCytochrome P450 3A7enzyme
DB00571PropranololSolute carrier family 22 member 2transporter
DB00571PropranololMultidrug resistance protein 1transporter
DB00571PropranololCytochrome P450 1A1enzyme
DB00571PropranololAmine oxidase [flavin-containing] Aenzyme
DB00571PropranololSerum albumincarrier
DB00641Simvastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB00641SimvastatinIntegrin beta-2target
DB00641SimvastatinCytochrome P450 3A4enzyme
DB00641SimvastatinCytochrome P450 2C8enzyme
DB00641SimvastatinCytochrome P450 2C9enzyme
DB00641SimvastatinCytochrome P450 2C19enzyme
DB00641SimvastatinCytochrome P450 3A5enzyme
DB00641SimvastatinCytochrome P450 3A7enzyme
DB00641SimvastatinMultidrug resistance protein 1transporter
DB00641SimvastatinSolute carrier organic anion transporter family member 1A2transporter
DB00641SimvastatinSolute carrier organic anion transporter family member 1B1transporter
DB00641SimvastatinCytochrome P450 2B6enzyme
DB00641SimvastatinCytochrome P450 2D6enzyme
DB00641SimvastatinUDP-glucuronosyltransferase 1-1enzyme
DB00641SimvastatinUDP-glucuronosyltransferase 1-3enzyme
DB00641SimvastatinUDP-glucuronosyltransferase 2B7enzyme
DB00641SimvastatinCanalicular multispecific organic anion transporter 1transporter
DB00641SimvastatinIntegrin alpha-Ltarget
DB00641SimvastatinBile salt export pumptransporter
DB00773EtoposideDNA topoisomerase 2-alphatarget
DB00773EtoposideCytochrome P450 3A4enzyme
DB00773EtoposideCanalicular multispecific organic anion transporter 2transporter
DB00773EtoposideMultidrug resistance-associated protein 6transporter
DB00773EtoposideMultidrug resistance protein 1transporter
DB00773EtoposideMultidrug resistance-associated protein 1transporter
DB00773EtoposideMultidrug resistance-associated protein 7transporter
DB00773EtoposideCanalicular multispecific organic anion transporter 1transporter
DB00773EtoposideATP-binding cassette sub-family G member 2transporter
DB00773EtoposideCytochrome P450 1A2enzyme
DB00773EtoposideCytochrome P450 2C8enzyme
DB00773EtoposideCytochrome P450 2E1enzyme
DB00773EtoposideCytochrome P450 3A5enzyme
DB00773EtoposideUDP-glucuronosyltransferase 1-1enzyme
DB00773EtoposideDNA topoisomerase 2-betatarget
DB00773EtoposideGlutathione S-transferase theta-1enzyme
DB00773EtoposideGlutathione S-transferase Penzyme
DB00773EtoposideProstaglandin G/H synthase 2enzyme
DB00773EtoposideProstaglandin G/H synthase 1enzyme
DB00788NaproxenProstaglandin G/H synthase 1target
DB00788NaproxenProstaglandin G/H synthase 2target
DB00788NaproxenSerum albumincarrier
DB00788NaproxenCytochrome P450 2C9enzyme
DB00788NaproxenCytochrome P450 1A2enzyme
DB00788NaproxenSolute carrier organic anion transporter family member 1A2transporter
DB00788NaproxenSolute carrier family 22 member 6transporter
DB00788NaproxenCytochrome P450 2C8enzyme
DB00788NaproxenUDP-glucuronosyltransferase 2B7enzyme
DB00788NaproxenPeptostreptococcal albumin-binding proteintarget
DB00788NaproxenBile salt export pumptransporter
DB00788NaproxenMultidrug resistance protein 1transporter
DB00788NaproxenUDP-glucuronosyltransferase 1A1enzyme
DB00788NaproxenUDP-glucuronosyltransferase 1-3enzyme
DB00788NaproxenUDP-glucuronosyltransferase 1-6enzyme
DB00788NaproxenUDP-glucuronosyltransferase 1-7enzyme
DB00788NaproxenUDP-glucuronosyltransferase 1-8enzyme
DB00788NaproxenUDP-glucuronosyltransferase 1-9enzyme
DB00788NaproxenUDP-glucuronosyltransferase 1-10enzyme
DB00788NaproxenSolute carrier family 22 member 8transporter
DB01012CinacalcetExtracellular calcium-sensing receptortarget
DB01012CinacalcetCytochrome P450 3A4enzyme
DB01012CinacalcetCytochrome P450 2D6enzyme
DB01012CinacalcetCytochrome P450 1A2enzyme
DB01022PhylloquinoneVitamin K-dependent gamma-carboxylasetarget
DB01022PhylloquinoneOsteocalcintarget
DB01104SertralineSodium-dependent serotonin transportertarget
DB01104SertralineCytochrome P450 2B6enzyme
DB01104SertralineCytochrome P450 2C19enzyme
DB01104SertralineCytochrome P450 2C9enzyme
DB01104SertralineCytochrome P450 2D6enzyme
DB01104SertralineSodium-dependent dopamine transportertarget
DB01104SertralineCYP2B proteinenzyme
DB01104SertralineCytochrome P450 3A4enzyme
DB01104SertralineAmine oxidase [flavin-containing] Benzyme
DB01104SertralineAmine oxidase [flavin-containing] Aenzyme
DB01104SertralineMultidrug resistance protein 1transporter
DB01104SertralineSerum albumincarrier
DB01104SertralineSigma receptortarget
DB01117AtovaquoneDihydroorotate dehydrogenase (quinone), mitochondrialtarget
DB01117AtovaquoneDihydroorotate dehydrogenase (quinone), mitochondrialtarget
DB01117AtovaquoneCytochrome btarget
DB01117AtovaquoneCytochrome P450 2C9enzyme
DB01117AtovaquoneCytochrome P450 3A4enzyme
DB01117AtovaquoneMultidrug resistance protein 1transporter
DB01179PodofiloxDNA topoisomerase 2-alphatarget
DB01179PodofiloxTubulin alpha-4A chaintarget
DB01179PodofiloxTubulin beta chaintarget
DB01209DezocineMu-type opioid receptortarget
DB01209DezocineKappa-type opioid receptortarget
DB01210LevobunololBeta-1 adrenergic receptortarget
DB01210LevobunololBeta-2 adrenergic receptortarget
DB01210LevobunololCytochrome P450 2D6enzyme
DB01388MibefradilVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
DB01388MibefradilVoltage-dependent T-type calcium channel subunit alpha-1Htarget
DB01388MibefradilVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB01388MibefradilVoltage-dependent L-type calcium channel subunit beta-1target
DB01388MibefradilCytochrome P450 3A4enzyme
DB01388MibefradilCytochrome P450 1A2enzyme
DB01388MibefradilCytochrome P450 2D6enzyme
DB01388MibefradilCytochrome P450 3A5enzyme
DB01388MibefradilCytochrome P450 3A7enzyme
DB01388MibefradilMultidrug resistance protein 1transporter
DB01388MibefradilVoltage-dependent T-type calcium channel subunit alpha-1Itarget
DB01388MibefradilVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB01388MibefradilVoltage-dependent L-type calcium channel subunit alpha-1Ftarget
DB01388MibefradilVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
DB01388MibefradilVoltage-dependent L-type calcium channel subunit beta-2target
DB01388MibefradilVoltage-dependent L-type calcium channel subunit beta-3target
DB01388MibefradilVoltage-dependent L-type calcium channel subunit beta-4target
DB01388MibefradilCytochrome P450 11B1, mitochondrialenzyme
DB01388MibefradilCytochrome P450 11B2, mitochondrialenzyme
DB01388MibefradilCytochrome P450 1A1enzyme
DB01668Nanaomycin DActVA 6 proteintarget
DB02866DansylamideCarbonic anhydrase 2target
DB03157N,O-Didansyl-L-TyrosineThymidylate synthasetarget
DB04640Naphthalene-2,6-disulfonic acidL-lactate dehydrogenasetarget
DB04640Naphthalene-2,6-disulfonic acidBacterioferritin comigratory proteintarget
DB04786SuraminNAD-dependent protein deacylase sirtuin-5, mitochondrialtarget
DB04786SuraminComplement control protein C3target
DB04786SuraminPhospholipase A2, membrane associatedtarget
DB04786SuraminProthrombintarget
DB04786SuraminP2Y purinoceptor 2target
DB04786SuraminFollicle-stimulating hormone receptortarget
DB04786SuraminRyanodine receptor 1target
DB04786SuraminArylsulfatase Aenzyme
DB04786SuraminCytosolic phospholipase A2enzyme
DB04942TamibaroteneRetinoic acid receptor alphatarget
DB04942TamibaroteneRetinoic acid receptor betatarget
DB04942TamibaroteneCellular retinoic acid-binding protein 1carrier
DB05022AmonafideDNA topoisomerase 2-alphatarget
DB05022AmonafideDNA topoisomerase 2-betatarget
DB05271RotigotineD(3) dopamine receptortarget
DB05271RotigotineD(1B) dopamine receptortarget
DB05271RotigotineD(4) dopamine receptortarget
DB05271RotigotineD(2) dopamine receptortarget
DB05271Rotigotine5-hydroxytryptamine receptor 1Atarget
DB05271RotigotineD(1A) dopamine receptortarget
DB05271RotigotineCytochrome P450 2D6enzyme
DB05271RotigotineCytochrome P450 3A4enzyme
DB05271RotigotineAlpha-2B adrenergic receptortarget
DB05395AmibegronBeta-3 adrenergic receptortarget
DB06202LasofoxifeneEstrogen receptor alphatarget
DB06202LasofoxifeneEstrogen receptor betatarget
DB06202LasofoxifeneCannabinoid receptor 2target
DB06693Mevastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB06693MevastatinLiver carboxylesterase 1enzyme
DB068753-(3-FLUORO-4-HYDROXYPHENYL)-7-HYDROXY-1-NAPHTHONITRILEEstrogen receptor betatarget
DB068753-(3-FLUORO-4-HYDROXYPHENYL)-7-HYDROXY-1-NAPHTHONITRILENuclear receptor coactivator 1target
DB076692,3-DIMETHYL-1,4-NAPHTHOQUINONEFumarate reductase flavoprotein subunittarget
DB076692,3-DIMETHYL-1,4-NAPHTHOQUINONEFumarate reductase iron-sulfur subunittarget
DB076692,3-DIMETHYL-1,4-NAPHTHOQUINONEFumarate reductase cytochrome b subunittarget
DB082542-NAPHTHALENESULFONIC ACIDProthrombintarget
DB082542-NAPHTHALENESULFONIC ACIDTrypsin-1target
DB12305DasotralineSodium-dependent dopamine transportertarget
DB12305DasotralineSodium-dependent serotonin transportertarget
DB12305DasotralineSodium-dependent noradrenaline transportertarget
DB14071DesmethylsertralineMultidrug resistance protein 1target
DB017501-naphthaleneacetic acidS-phase kinase-associated protein 1target
DB019416-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)Cyclopropyl]Pyridine-3-Carboxylic AcidRetinoic acid receptor RXR-betatarget
DB11948LapachoneRetinol-binding protein 3target