Naphthalenes

Two-ring crystalline hydrocarbons isolated from coal tar. They are used as intermediates in chemical synthesis, as insect repellents, fungicides, lubricants, preservatives, and, formerly, as topical antiseptics.
DrugDrug NameDrug Description
DB00170MenadioneThe primary known function of vitamin K is to assist in the normal clotting of blood, but it may also play a role in normal bone calcification.
DB00210AdapaleneA topical retinoid agent used for the treatment of acne vulgaris.
DB00307BexaroteneA retinoid drug used for cutaneous manifestations of T-cell lymphoma in patients who have not responded well to previous systemic therapy.
DB00525TolnaftateAn antifungal agent used to treat various skin infections caused by fungi.
DB00571PropranololA non-selective beta adrenergic antagonist used to treat hypertension, angina, atrial fibrillation, myocardial infarction, migraine, essential tremor, hypertrophic subaortic stenosis, and pheochromocytoma.
DB00641SimvastatinAn HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular events including myocardial infarction and stroke.
DB00773EtoposideA podophyllotoxin derivative used to treat testicular and small cell lung tumors.
DB00788NaproxenAn NSAID used to treat rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, tendinitis, bursitis, acute gout, primary dysmenorrhea, and mild to moderate pain.
DB01012CinacalcetA calcium sensing receptor agonist used to treat secondary hyperparathyroidism in chronic kidney disease and hypercalcemia in parathyroid carcinoma.
DB01022PhylloquinoneA fat soluble vitamin used to treat hemorrhagic conditions in infants and coumarin overdoses.
DB01104SertralineA selective serotonin reuptake inhibitor (SSRI) indicated to treat major depressive disorder, social anxiety disorder and many other psychiatric conditions.
DB01117AtovaquoneAn antimicrobial indicated for the prevention and treatment of Pneumocystis jirovecii pneumonia (PCP) and for the prevention and treatment of Plasmodium falciparum malaria.
DB01179PodofiloxA topical agent used for the treatment of external genital warts and perianal warts.
DB01209DezocineIndicated in the treatment of moderate to severe pain.
DB01210LevobunololA beta-adrenergic antagonist used for the reduction of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
DB01388MibefradilFor the treatment of angina and high blood pressure.
DB01668Nanaomycin DNot Available
DB02866DansylamideNot Available
DB03157N,O-Didansyl-L-TyrosineNot Available
DB04640Naphthalene-2,6-disulfonic acidNot Available
DB04744LawsoneNot Available
DB04786SuraminFor treatment of human sleeping sickness, onchocerciasis and other diseases caused by trypanosomes and worms.
DB04942TamibaroteneInvestigated for use/treatment in leukemia (unspecified).
DB05022AmonafideInvestigated for use/treatment in breast cancer, ovarian cancer, and prostate cancer.
DB05271RotigotineA non-selective dopamine agonist used for the treatment of Parkinson's Disease and Restless Leg Syndrome.
DB05385PRO 2000Investigated for use/treatment in HIV prevention, prevention of stdis, and vaginal infection.
DB05395AmibegronInvestigated for use/treatment in depression, irritable bowel syndrome (IBS), and obesity.
DB06202LasofoxifeneInvestigated for use/treatment in postmenopausal osteoporosis to reduce the risk of both vertebral and novertebral fractures, as well as address other postmenopausal conditions, including reduction in risk of breast cancer...
DB06682NaproxcinodInvestigated for use/treatment in pain (acute or chronic), inflammatory disorders (unspecified), osteoarthritis, and arthritis and arthritic pain.
DB06693MevastatinNot used therapeutically due to its many side effects.
DB06740BW-A 58CBW-A 58C, also known as 2-(4-tert-butylcyclohexyl)-3-hydroxy-1,4-naphthoquinone, is an experimental naphthoquinone antimalarial drug which undergoes extensive alkyl hydroxylation to a single t-butylhydroxy metabolite in man in vivo and also in human...
DB068753-(3-FLUORO-4-HYDROXYPHENYL)-7-HYDROXY-1-NAPHTHONITRILENot Available
DB076692,3-DIMETHYL-1,4-NAPHTHOQUINONENot Available
DB082542-NAPHTHALENESULFONIC ACIDNot Available
DB09158Trypan blue free acidA dye used as a visualizing aid to stain the epiretinal membranes during ophthalmic surgical vitrectomy procedures, thereby facilitating removal of the tissue.
DB11267TriethoxycaprylylsilaneNot Annotated
DB11806VTP-194204Nrx194204 has been used in trials studying the treatment of Parkinson's Disease and Non-small Cell Lung Cancer.
DB12005NirogacestatNirogacestat has been used in trials studying the treatment of Breast Cancer, HIV Infection, Desmoid Tumors, Advanced Solid Tumors, and Aggressive Fibromatosis, among others.
DB12148MenatetrenoneMenatetrenone has been used in trials studying the treatment of Diabetes, Osteoporosis, Prediabetic State, and Hepatocellular Carcinoma.
DB12220ORG-25935Org 25935 has been used in trials studying the treatment of Alcoholism, Schizophrenia, and Panic Disorder.
DB12305DasotralineDasotraline is a serotonin, norepinephrine and dopamine reuptake inhibitor (SNDRI) that is under investigation for the treatment of Binge Eating Disorder, Adult Attention Hyperactivity Disorder, Attention Deficit Hyperactivity Disorder, and...
DB12467TU-100TU-100 has been used in trials studying the treatment of Abdominal Pain, Colonic Transit, Crohn's Disease, Rectal Sensation, and Gastric Emptying, among others.
DB12802PicropodophyllinPicropodophyllin has been investigated for the treatment of Non Small Cell Lung Cancer.
DB13075Menaquinone 7Menaquinone 7 is under investigation in clinical trial NCT00402974 (The Effect of Vitamin K Supplementation on Osteocalcin Carboxylation in Healthy Children).
DB13652BunaftineNot Annotated
DB13680NaftazoneNot Annotated
DB14071DesmethylsertralineDesmethylsertraline is a metabolite of sertraline.
DB14636Triciribine phosphateNot Annotated
DB14650Menadiol diphosphateNot Annotated
DB017501-naphthaleneacetic acidNot Available
DB019416-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)Cyclopropyl]Pyridine-3-Carboxylic AcidNot Available
DB03322DexpropranololNot Available
DB11948LapachoneLapachone has been used in trials studying the treatment of Cancer, Carcinoma, Advanced Solid Tumors, Head and Neck Neoplasms, and Carcinoma, Squamous Cell.
DB14936Menaquinone 6Menaquinone 6 is under investigation in clinical trial NCT01194778 (Comparison of Efficacy of Different Dosages Vitamin K2).
DB15377ATB-346ATB-346 is under investigation in clinical trial NCT03220633 (Study To Assess Safety, Tolerability And PK Of ATB-346 In Healthy Subjects).
DB15381MenaquinoneMenaquinone is under investigation in clinical trial NCT01533441 (Vitamin K2 Intervention in Patients With Vitamin K Antagonists).
DB00857TerbinafineAn allylamine antifungal used to treat dermatophyte infections of toenails and fingernails as well as other fungal skin infections.
DB06374ElacestrantInvestigated for use/treatment in menopause and female hormonal deficiencies/abnormalities.
DB12134GepotidacinGepotidacin has been used in trials studying the treatment of Gonorrhea, Infections, Bacterial, and Infections, Respiratory Tract.
DB12155NapabucasinNapabucasin has been investigated for the treatment of Colorectal Carcinoma.
DB02521FlaviolinNot Available
DrugDrug NameTargetType
DB00170MenadioneVitamin K-dependent protein Ztarget
DB00170MenadioneProthrombintarget
DB00170MenadioneVitamin K epoxide reductase complex subunit 1target
DB00170MenadioneCoagulation factor IXtarget
DB00170MenadioneCoagulation factor VIItarget
DB00170MenadioneCoagulation factor Xtarget
DB00170MenadioneVitamin K-dependent gamma-carboxylasetarget
DB00170MenadioneVitamin K-dependent protein Ctarget
DB00170MenadioneVitamin K-dependent protein Starget
DB00170MenadioneNAD(P)H dehydrogenase [quinone] 1target
DB00170MenadioneRibosyldihydronicotinamide dehydrogenase [quinone]target
DB00170MenadioneVitamin K epoxide reductase complex subunit 1-like protein 1target
DB00170MenadioneXanthine dehydrogenase/oxidaseenzyme
DB00170MenadioneAldehyde oxidaseenzyme
DB00170MenadioneMethylenetetrahydrofolate reductaseenzyme
DB00170MenadioneCytochrome P450 1A1enzyme
DB00170MenadioneOsteocalcintarget
DB00170MenadioneCytochrome P450 1A2enzyme
DB00170MenadioneCytochrome P450 2A6enzyme
DB00210AdapaleneRetinoic acid receptor alphatarget
DB00210AdapaleneRetinoic acid receptor RXR-betatarget
DB00210AdapaleneRetinoic acid receptor gammatarget
DB00210AdapaleneRetinoic acid receptor betatarget
DB00210AdapaleneRetinoic acid receptor RXR-gammatarget
DB00210AdapaleneRetinoic acid receptor RXR-alphatarget
DB00210AdapaleneProstaglandin G/H synthase 2target
DB00307BexaroteneRetinoic acid receptor RXR-betatarget
DB00307BexaroteneCytochrome P450 3A4enzyme
DB00307BexaroteneRetinoic acid receptor RXR-alphatarget
DB00307BexaroteneRetinoic acid receptor RXR-gammatarget
DB00307BexaroteneCytochrome P450 2C8enzyme
DB00525TolnaftateSqualene monooxygenasetarget
DB00571PropranololBeta-1 adrenergic receptortarget
DB00571PropranololBeta-2 adrenergic receptortarget
DB00571PropranololBeta-3 adrenergic receptortarget
DB00571Propranolol5-hydroxytryptamine receptor 1Atarget
DB00571Propranolol5-hydroxytryptamine receptor 1Btarget
DB00571PropranololCytochrome P450 1A2enzyme
DB00571PropranololCytochrome P450 2D6enzyme
DB00571PropranololAlpha-1-acid glycoprotein 1carrier
DB00571PropranololCytochrome P450 2C19enzyme
DB00571PropranololCytochrome P450 3A4enzyme
DB00571PropranololCytochrome P450 3A5enzyme
DB00571PropranololCytochrome P450 3A7enzyme
DB00571PropranololSolute carrier family 22 member 2transporter
DB00571PropranololP-glycoprotein 1transporter
DB00571PropranololCytochrome P450 1A1enzyme
DB00571PropranololAmine oxidase [flavin-containing] Aenzyme
DB00571PropranololSerum albumincarrier
DB00641Simvastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB00641SimvastatinCytochrome P450 3A4enzyme
DB00641SimvastatinCytochrome P450 2C8enzyme
DB00641SimvastatinCytochrome P450 2C9enzyme
DB00641SimvastatinCytochrome P450 3A5enzyme
DB00641SimvastatinP-glycoprotein 1transporter
DB00641SimvastatinSolute carrier organic anion transporter family member 1A2transporter
DB00641SimvastatinSolute carrier organic anion transporter family member 1B1transporter
DB00641SimvastatinCytochrome P450 2B6enzyme
DB00641SimvastatinCytochrome P450 2D6enzyme
DB00641SimvastatinUDP-glucuronosyltransferase 1-1enzyme
DB00641SimvastatinUDP-glucuronosyltransferase 1-3enzyme
DB00641SimvastatinUDP-glucuronosyltransferase 2B7enzyme
DB00641SimvastatinCanalicular multispecific organic anion transporter 1transporter
DB00641SimvastatinIntegrin alpha-Ltarget
DB00641SimvastatinBile salt export pumptransporter
DB00641SimvastatinCytochrome P450 2C19enzyme
DB00641SimvastatinSolute carrier organic anion transporter family member 2B1transporter
DB00641SimvastatinSolute carrier organic anion transporter family member 1B3transporter
DB00641SimvastatinHistone deacetylase 2target
DB00773EtoposideDNA topoisomerase 2-alphatarget
DB00773EtoposideCytochrome P450 3A4enzyme
DB00773EtoposideCanalicular multispecific organic anion transporter 2transporter
DB00773EtoposideMultidrug resistance-associated protein 6transporter
DB00773EtoposideP-glycoprotein 1transporter
DB00773EtoposideMultidrug resistance-associated protein 1transporter
DB00773EtoposideMultidrug resistance-associated protein 7transporter
DB00773EtoposideCanalicular multispecific organic anion transporter 1transporter
DB00773EtoposideATP-binding cassette sub-family G member 2transporter
DB00773EtoposideCytochrome P450 1A2enzyme
DB00773EtoposideCytochrome P450 2E1enzyme
DB00773EtoposideCytochrome P450 3A5enzyme
DB00773EtoposideUDP-glucuronosyltransferase 1-1enzyme
DB00773EtoposideDNA topoisomerase 2-betatarget
DB00773EtoposideGlutathione S-transferase theta-1enzyme
DB00773EtoposideGlutathione S-transferase Penzyme
DB00773EtoposideProstaglandin G/H synthase 2enzyme
DB00773EtoposideProstaglandin G/H synthase 1enzyme
DB00788NaproxenProstaglandin G/H synthase 1target
DB00788NaproxenProstaglandin G/H synthase 2target
DB00788NaproxenSerum albumincarrier
DB00788NaproxenCytochrome P450 2C9enzyme
DB00788NaproxenCytochrome P450 1A2enzyme
DB00788NaproxenSolute carrier organic anion transporter family member 1A2transporter
DB00788NaproxenSolute carrier family 22 member 6transporter
DB00788NaproxenCytochrome P450 2C8enzyme
DB00788NaproxenUDP-glucuronosyltransferase 2B7enzyme
DB00788NaproxenPeptostreptococcal albumin-binding proteintarget
DB00788NaproxenBile salt export pumptransporter
DB00788NaproxenP-glycoprotein 1transporter
DB00788NaproxenUDP-glucuronosyltransferase 1-3enzyme
DB00788NaproxenUDP-glucuronosyltransferase 1-6enzyme
DB00788NaproxenUDP-glucuronosyltransferase 1-7enzyme
DB00788NaproxenUDP-glucuronosyltransferase 1-8enzyme
DB00788NaproxenUDP-glucuronosyltransferase 1-9enzyme
DB00788NaproxenUDP-glucuronosyltransferase 1-10enzyme
DB00788NaproxenSolute carrier family 22 member 8transporter
DB01012CinacalcetExtracellular calcium-sensing receptortarget
DB01012CinacalcetCytochrome P450 3A4enzyme
DB01012CinacalcetCytochrome P450 2D6enzyme
DB01012CinacalcetCytochrome P450 1A2enzyme
DB01022PhylloquinoneVitamin K-dependent gamma-carboxylasetarget
DB01022PhylloquinoneOsteocalcintarget
DB01104SertralineSodium-dependent serotonin transportertarget
DB01104SertralineCytochrome P450 2B6enzyme
DB01104SertralineCytochrome P450 2C19enzyme
DB01104SertralineCytochrome P450 2C9enzyme
DB01104SertralineCytochrome P450 2D6enzyme
DB01104SertralineSodium-dependent dopamine transportertarget
DB01104SertralineCYP2B proteinenzyme
DB01104SertralineCytochrome P450 3A4enzyme
DB01104SertralineAmine oxidase [flavin-containing] Benzyme
DB01104SertralineAmine oxidase [flavin-containing] Aenzyme
DB01104SertralineP-glycoprotein 1transporter
DB01104SertralineSerum albumincarrier
DB01104SertralineSigma receptortarget
DB01104SertralineSodium-dependent noradrenaline transportertarget
DB01104SertralineEquilibrative nucleoside transporter 4target
DB01104SertralineCytochrome P450 2E1enzyme
DB01117AtovaquoneDihydroorotate dehydrogenase (quinone), mitochondrialtarget
DB01117AtovaquoneDihydroorotate dehydrogenase (quinone), mitochondrialtarget
DB01117AtovaquoneCytochrome btarget
DB01117AtovaquoneCytochrome P450 2C9enzyme
DB01117AtovaquoneCytochrome P450 3A4enzyme
DB01117AtovaquoneP-glycoprotein 1transporter
DB01179PodofiloxDNA topoisomerase 2-alphatarget
DB01179PodofiloxTubulin alpha-4A chaintarget
DB01179PodofiloxTubulin beta chaintarget
DB01209DezocineMu-type opioid receptortarget
DB01209DezocineKappa-type opioid receptortarget
DB01210LevobunololBeta-1 adrenergic receptortarget
DB01210LevobunololBeta-2 adrenergic receptortarget
DB01210LevobunololCytochrome P450 2D6enzyme
DB01388MibefradilVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
DB01388MibefradilVoltage-dependent T-type calcium channel subunit alpha-1Htarget
DB01388MibefradilVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB01388MibefradilVoltage-dependent L-type calcium channel subunit beta-1target
DB01388MibefradilCytochrome P450 3A4enzyme
DB01388MibefradilCytochrome P450 1A2enzyme
DB01388MibefradilCytochrome P450 2D6enzyme
DB01388MibefradilCytochrome P450 3A5enzyme
DB01388MibefradilCytochrome P450 3A7enzyme
DB01388MibefradilP-glycoprotein 1transporter
DB01388MibefradilVoltage-dependent T-type calcium channel subunit alpha-1Itarget
DB01388MibefradilVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB01388MibefradilVoltage-dependent L-type calcium channel subunit alpha-1Ftarget
DB01388MibefradilVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
DB01388MibefradilVoltage-dependent L-type calcium channel subunit beta-2target
DB01388MibefradilVoltage-dependent L-type calcium channel subunit beta-3target
DB01388MibefradilVoltage-dependent L-type calcium channel subunit beta-4target
DB01388MibefradilCytochrome P450 11B1, mitochondrialenzyme
DB01388MibefradilCytochrome P450 11B2, mitochondrialenzyme
DB01668Nanaomycin DActVA 6 proteintarget
DB02866DansylamideCarbonic anhydrase 2target
DB03157N,O-Didansyl-L-TyrosineThymidylate synthasetarget
DB04640Naphthalene-2,6-disulfonic acidL-lactate dehydrogenasetarget
DB04640Naphthalene-2,6-disulfonic acidBacterioferritin comigratory proteintarget
DB04786SuraminNAD-dependent protein deacylase sirtuin-5, mitochondrialtarget
DB04786SuraminComplement control protein C3target
DB04786SuraminPhospholipase A2, membrane associatedtarget
DB04786SuraminProthrombintarget
DB04786SuraminP2Y purinoceptor 2target
DB04786SuraminFollicle-stimulating hormone receptortarget
DB04786SuraminRyanodine receptor 1target
DB04786SuraminArylsulfatase Aenzyme
DB04786SuraminCytosolic phospholipase A2enzyme
DB04942TamibaroteneRetinoic acid receptor alphatarget
DB04942TamibaroteneRetinoic acid receptor betatarget
DB04942TamibaroteneCellular retinoic acid-binding protein 1carrier
DB05022AmonafideDNA topoisomerase 2-alphatarget
DB05022AmonafideDNA topoisomerase 2-betatarget
DB05271RotigotineDopamine D3 receptortarget
DB05271RotigotineDopamine D5 receptortarget
DB05271RotigotineDopamine D4 receptortarget
DB05271RotigotineDopamine D2 receptortarget
DB05271Rotigotine5-hydroxytryptamine receptor 1Atarget
DB05271RotigotineDopamine D1 receptortarget
DB05271RotigotineCytochrome P450 2D6enzyme
DB05271RotigotineCytochrome P450 3A4enzyme
DB05271RotigotineAlpha-2B adrenergic receptortarget
DB05395AmibegronBeta-3 adrenergic receptortarget
DB06202LasofoxifeneEstrogen receptor alphatarget
DB06202LasofoxifeneEstrogen receptor betatarget
DB06202LasofoxifeneCannabinoid receptor 2target
DB06693Mevastatin3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB06693MevastatinLiver carboxylesterase 1enzyme
DB068753-(3-FLUORO-4-HYDROXYPHENYL)-7-HYDROXY-1-NAPHTHONITRILEEstrogen receptor betatarget
DB068753-(3-FLUORO-4-HYDROXYPHENYL)-7-HYDROXY-1-NAPHTHONITRILENuclear receptor coactivator 1target
DB076692,3-DIMETHYL-1,4-NAPHTHOQUINONEFumarate reductase flavoprotein subunittarget
DB076692,3-DIMETHYL-1,4-NAPHTHOQUINONEFumarate reductase iron-sulfur subunittarget
DB076692,3-DIMETHYL-1,4-NAPHTHOQUINONEFumarate reductase cytochrome b subunittarget
DB082542-NAPHTHALENESULFONIC ACIDProthrombintarget
DB082542-NAPHTHALENESULFONIC ACIDTrypsin-1target
DB12305DasotralineSodium-dependent dopamine transportertarget
DB12305DasotralineSodium-dependent serotonin transportertarget
DB12305DasotralineSodium-dependent noradrenaline transportertarget
DB14071DesmethylsertralineP-glycoprotein 1target
DB017501-naphthaleneacetic acidS-phase kinase-associated protein 1target
DB019416-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)Cyclopropyl]Pyridine-3-Carboxylic AcidRetinoic acid receptor RXR-betatarget
DB11948LapachoneRetinol-binding protein 3target
DB00857TerbinafineSqualene monooxygenasetarget
DB00857TerbinafineCytochrome P450 2D6enzyme
DB00857TerbinafineCytochrome P450 2C9enzyme
DB00857TerbinafineCytochrome P450 1A2enzyme
DB00857TerbinafineCytochrome P450 3A4enzyme
DB00857TerbinafineCytochrome P450 2C8enzyme
DB00857TerbinafineCytochrome P450 2C19enzyme
DB00857TerbinafineProstaglandin G/H synthase 1enzyme
DB00857TerbinafineSerum albumincarrier
DB00857Terbinafinealpha1-acid glycoproteincarrier
DB00857TerbinafineABC multidrug transporter MDR2transporter
DB00857TerbinafineSqualene monooxygenasetarget
DB06374ElacestrantEstrogen receptor alphatarget
DB02521FlaviolinPutative cytochrome P450target
DB02521FlaviolinPrenyltransferasetarget