Identification

Name
Carfentanil
Accession Number
DB01535
Type
Small Molecule
Groups
Illicit, Vet Approved
Description

Carfentanil or carfentanyl (Wildnil) is an analogue of the popular synthetic opioid analgesic fentanyl, and is one of the most potent opioids known (also the most potent opioid used commercially). Carfentanil was first synthesized in 1974 by a team of chemists at Janssen Pharmaceutica which included Paul Janssen. It has a quantitative potency approximately 10,000 times that of morphine and 100 times that of fentanyl, with activity in humans starting at about 1 microgram. It is marketed under the trade name Wildnil as a general anaesthetic agent for large animals. Carfentanil is intended for large-animal use only as its extreme potency makes it inappropriate for use in humans. Currently sufentanil, approximately 10–20 times less potent (500 to 1000 times the efficacy of morphine per weight) than carfentanil, is the maximum strength fentanyl analog for use in humans.

Structure
Thumb
Synonyms
  • Carfentanyl
Product Ingredients
IngredientUNIICASInChI Key
Carfentanil citrate7LG286J8GV 61380-27-6ZSLYVCXNFQPCGT-UHFFFAOYSA-N
Categories
UNII
LA9DTA2L8F
CAS number
59708-52-0
Weight
Average: 394.5066
Monoisotopic: 394.225642836
Chemical Formula
C24H30N2O3
InChI Key
YDSDEBIZUNNPOB-UHFFFAOYSA-N
InChI
InChI=1S/C24H30N2O3/c1-3-22(27)26(21-12-8-5-9-13-21)24(23(28)29-2)15-18-25(19-16-24)17-14-20-10-6-4-7-11-20/h4-13H,3,14-19H2,1-2H3
IUPAC Name
methyl 1-(2-phenylethyl)-4-(N-phenylpropanamido)piperidine-4-carboxylate
SMILES
CCC(=O)N(C1=CC=CC=C1)C1(CCN(CCC2=CC=CC=C2)CC1)C(=O)OC

Pharmacology

Indication

Carfentanil is similar (but more potent) to the opioid analgesic fentanyl. It is used as a tranquilizer for large animals.

Structured Indications
Not Available
Pharmacodynamics

Carfentanil acts primarily on the mu (some kappa and delta) opioid receptors as an agonist. It will induce similar effects of analgesia as other opioids, however, due to its potency, it will also induce strong side effects such as sedation. Consequently, that is why it is used as a tranquilizer for large animals.

Carfentanil interacts predominately with the opioid mu-receptor. These mu-binding sites are discretely distributed in the brain, spinal cord, and other tissues. It exerts its principal pharmacologic effects on the central nervous system. Its primary actions of therapeutic value are analgesia and sedation. Carfentanil also depresses the respiratory centers, depresses the cough reflex, and constricts the pupils.

Mechanism of action

Carfentanil binds very strongly to mu opioid receptors and acts as a competitive agonist. Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.

TargetActionsOrganism
AMu-type opioid receptor
agonist
Human
ADelta-type opioid receptor
agonist
Human
UKappa-type opioid receptor
agonist
Human
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
PathwayCategory
Carfentanil Action PathwayDrug action
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
2,5-Dimethoxy-4-ethylamphetamine2,5-Dimethoxy-4-ethylamphetamine may increase the analgesic activities of Carfentanil.Experimental, Illicit
3,4-Methylenedioxyamphetamine3,4-Methylenedioxyamphetamine may increase the analgesic activities of Carfentanil.Experimental, Illicit
4-Bromo-2,5-dimethoxyamphetamine4-Bromo-2,5-dimethoxyamphetamine may increase the analgesic activities of Carfentanil.Experimental, Illicit
7-NitroindazoleThe risk or severity of adverse effects can be increased when Carfentanil is combined with 7-Nitroindazole.Experimental
7,8-Dichloro-1,2,3,4-tetrahydroisoquinolineThe risk or severity of adverse effects can be increased when Carfentanil is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.Experimental
AcepromazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Acepromazine.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Aceprometazine.Approved
AcetazolamideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Acetazolamide.Approved, Vet Approved
AclidiniumThe risk or severity of adverse effects can be increased when Aclidinium is combined with Carfentanil.Approved
AdipiplonThe risk or severity of adverse effects can be increased when Carfentanil is combined with Adipiplon.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Agomelatine.Approved, Investigational
AlaproclateCarfentanil may increase the serotonergic activities of Alaproclate.Experimental
AlcuroniumThe risk or severity of adverse effects can be increased when Alcuronium is combined with Carfentanil.Experimental
AlfaxaloneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Alfaxalone.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Carfentanil.Approved, Illicit
AlimemazineAlimemazine may increase the hypotensive activities of Carfentanil.Approved, Vet Approved
AllopregnanoloneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Allopregnanolone.Investigational
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Carfentanil is combined with Alphacetylmethadol.Experimental, Illicit
AlphaprodineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Alphaprodine.Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Carfentanil.Approved, Illicit, Investigational
AlvimopanThe risk or severity of adverse effects can be increased when Carfentanil is combined with Alvimopan.Approved
AmilorideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Amiloride.Approved
AmisulprideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Amisulpride.Approved, Investigational
AmitriptylineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Amitriptyline.Approved
Ammonium chlorideAmmonium chloride may increase the excretion rate of Carfentanil which could result in a lower serum level and potentially a reduction in efficacy.Approved, Vet Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Carfentanil.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Amoxapine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Amperozide.Experimental
AmphetamineAmphetamine may increase the analgesic activities of Carfentanil.Approved, Illicit
Anisotropine MethylbromideThe risk or severity of adverse effects can be increased when Anisotropine Methylbromide is combined with Carfentanil.Approved
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Carfentanil.Approved, Investigational
ArticaineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Articaine.Approved
AsenapineThe risk or severity of adverse effects can be increased when Asenapine is combined with Carfentanil.Approved
AtracuriumThe risk or severity of adverse effects can be increased when Atracurium is combined with Carfentanil.Experimental
Atracurium besylateThe risk or severity of adverse effects can be increased when Atracurium besylate is combined with Carfentanil.Approved
AtropineThe risk or severity of adverse effects can be increased when Atropine is combined with Carfentanil.Approved, Vet Approved
AzaperoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Azaperone.Vet Approved
AzelastineCarfentanil may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
AzosemideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Azosemide.Investigational
BaclofenThe risk or severity of adverse effects can be increased when Carfentanil is combined with Baclofen.Approved
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Carfentanil.Illicit
BenactyzineThe risk or severity of adverse effects can be increased when Benactyzine is combined with Carfentanil.Withdrawn
BendroflumethiazideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Bendroflumethiazide.Approved
BenmoxinThe risk or severity of adverse effects can be increased when Carfentanil is combined with Benmoxin.Withdrawn
BenperidolThe risk or severity of adverse effects can be increased when Carfentanil is combined with Benperidol.Investigational
BenzatropineThe risk or severity of adverse effects can be increased when Benzatropine is combined with Carfentanil.Approved
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Carfentanil.Approved
BenzphetamineBenzphetamine may increase the analgesic activities of Carfentanil.Approved, Illicit
Benzyl alcoholThe risk or severity of adverse effects can be increased when Carfentanil is combined with Benzyl alcohol.Approved
BiperidenThe risk or severity of adverse effects can be increased when Biperiden is combined with Carfentanil.Approved
BL-1020BL-1020 may increase the hypotensive activities of Carfentanil.Investigational
BornaprineThe risk or severity of adverse effects can be increased when Bornaprine is combined with Carfentanil.Experimental
BrexpiprazoleThe risk or severity of adverse effects can be increased when Carfentanil is combined with Brexpiprazole.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.Approved
BrofaromineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Brofaromine.Experimental
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Carfentanil.Approved, Illicit
BromisovalThe risk or severity of adverse effects can be increased when Carfentanil is combined with Bromisoval.Experimental
BromperidolThe risk or severity of adverse effects can be increased when Carfentanil is combined with Bromperidol.Investigational
BrompheniramineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Brompheniramine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Brotizolam.Approved, Withdrawn
BumetanideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Bumetanide.Approved
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Carfentanil.Approved, Investigational
BuprenorphineCarfentanil may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Carfentanil.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Carfentanil.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Butacaine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Carfentanil is combined with Butalbital.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Carfentanil is combined with Butamben.Approved
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Carfentanil.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Carfentanil.Approved, Illicit, Vet Approved
CanertinibThe risk or severity of adverse effects can be increased when Carfentanil is combined with Canertinib.Investigational
Canrenoic acidThe risk or severity of adverse effects can be increased when Carfentanil is combined with Canrenoic acid.Approved, Withdrawn
CanrenoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Canrenone.Investigational
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Carfentanil.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Carbinoxamine.Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Carfentanil is combined with Carisoprodol.Approved
CaroxazoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Caroxazone.Withdrawn
CetirizineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Cetirizine.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Carfentanil is combined with Chloral hydrate.Approved, Illicit, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Carfentanil.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Carfentanil.Approved, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Carfentanil.Approved
ChlorothiazideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Chlorothiazide.Approved, Vet Approved
ChlorphenamineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Chlorphenamine.Approved
ChlorphenoxamineThe risk or severity of adverse effects can be increased when Chlorphenoxamine is combined with Carfentanil.Withdrawn
ChlorphentermineChlorphentermine may increase the analgesic activities of Carfentanil.Illicit, Withdrawn
ChlorproethazineChlorproethazine may increase the hypotensive activities of Carfentanil.Experimental
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Carfentanil.Approved, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Carfentanil.Approved, Withdrawn
ChlorthalidoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Chlorthalidone.Approved
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Chlorzoxazone.Approved
CicletanineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Cicletanine.Investigational
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Carfentanil.Approved, Vet Approved
CitalopramCarfentanil may increase the serotonergic activities of Citalopram.Approved
ClemastineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Clemastine.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Carfentanil is combined with Clidinium.Approved
ClobazamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Clobazam.Approved, Illicit
ClofenamideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Clofenamide.Experimental
clomethiazoleThe risk or severity of adverse effects can be increased when Carfentanil is combined with clomethiazole.Investigational
ClomipramineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Clomipramine.Approved, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Clonazepam.Approved, Illicit
ClonidineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Clonidine.Approved
ClopamideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Clopamide.Experimental
ClopenthixolThe risk or severity of adverse effects can be increased when Carfentanil is combined with Clopenthixol.Experimental
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Carfentanil.Approved, Illicit
ClorexoloneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Clorexolone.Experimental
ClothiapineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Clothiapine.Experimental
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Carfentanil.Approved
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Carfentanil.Approved, Illicit
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Carfentanil.Approved, Illicit
ConivaptanThe risk or severity of adverse effects can be increased when Carfentanil is combined with Conivaptan.Approved, Investigational
CyclizineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Cyclizine.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Carfentanil.Approved
CyclopenthiazideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Cyclopenthiazide.Experimental
CyclopentolateThe risk or severity of adverse effects can be increased when Cyclopentolate is combined with Carfentanil.Approved
CyclothiazideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Cyclothiazide.Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Cyproheptadine.Approved
DantroleneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Dantrolene.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Carfentanil.Approved
DapoxetineCarfentanil may increase the serotonergic activities of Dapoxetine.Investigational
DarifenacinThe risk or severity of adverse effects can be increased when Darifenacin is combined with Carfentanil.Approved, Investigational
DeramciclaneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Deramciclane.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Carfentanil.Approved
DesipramineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Desipramine.Approved
DesloratadineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Desloratadine.Approved, Investigational
DesmopressinThe risk or severity of adverse effects can be increased when Carfentanil is combined with Desmopressin.Approved
DesvenlafaxineCarfentanil may increase the serotonergic activities of Desvenlafaxine.Approved
DetomidineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Detomidine.Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Dexbrompheniramine.Approved
DexetimideThe risk or severity of adverse effects can be increased when Dexetimide is combined with Carfentanil.Withdrawn
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Carfentanil.Approved, Vet Approved
DextroamphetamineDextroamphetamine may increase the analgesic activities of Carfentanil.Approved, Illicit
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Carfentanil.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Carfentanil.Approved, Illicit, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Carfentanil.Approved
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Carfentanil.Approved, Illicit, Vet Approved
DicyclomineThe risk or severity of adverse effects can be increased when Dicyclomine is combined with Carfentanil.Approved
Diethyl etherThe risk or severity of adverse effects can be increased when Carfentanil is combined with Diethyl ether.Experimental
DiethylpropionDiethylpropion may increase the analgesic activities of Carfentanil.Approved, Illicit
DifenoxinThe risk or severity of adverse effects can be increased when Carfentanil is combined with Difenoxin.Approved, Illicit
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Carfentanil.Approved, Illicit
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Carfentanil.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Dihydromorphine.Experimental, Illicit
DimenhydrinateThe risk or severity of adverse effects can be increased when Carfentanil is combined with Dimenhydrinate.Approved
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Carfentanil.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Carfentanil.Approved, Illicit
DixyrazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Dixyrazine.Experimental
DoramectinThe risk or severity of adverse effects can be increased when Carfentanil is combined with Doramectin.Vet Approved
DoxepinThe risk or severity of adverse effects can be increased when Carfentanil is combined with Doxepin.Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when Carfentanil is combined with DPDPE.Investigational
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.Approved, Illicit
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.Approved, Vet Approved
DrospirenoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Drospirenone.Approved
DrotebanolThe risk or severity of adverse effects can be increased when Carfentanil is combined with Drotebanol.Experimental, Illicit
DuloxetineCarfentanil may increase the serotonergic activities of Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Carfentanil.Approved
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Carfentanil.Experimental, Illicit
EcopipamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ecopipam.Investigational
EfavirenzThe risk or severity of adverse effects can be increased when Carfentanil is combined with Efavirenz.Approved, Investigational
EfonidipineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Efonidipine.Approved
EltanoloneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Eltanolone.Investigational
EluxadolineCarfentanil may increase the constipating activities of Eluxadoline.Approved
EmeproniumThe risk or severity of adverse effects can be increased when Emepronium is combined with Carfentanil.Experimental
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Carfentanil.Approved, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Carfentanil is combined with Entacapone.Approved, Investigational
EplerenoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Eplerenone.Approved
EscitalopramCarfentanil may increase the serotonergic activities of Escitalopram.Approved, Investigational
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Carfentanil.Approved, Illicit
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Carfentanil.Approved
Etacrynic acidThe risk or severity of adverse effects can be increased when Carfentanil is combined with Etacrynic acid.Approved
EtanautineThe risk or severity of adverse effects can be increased when Etanautine is combined with Carfentanil.Experimental
EthanolCarfentanil may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Carfentanil.Approved, Illicit, Withdrawn
EthopropazineThe risk or severity of adverse effects can be increased when Ethopropazine is combined with Carfentanil.Approved
EthosuximideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ethosuximide.Approved
EthotoinThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ethotoin.Approved
EthoxzolamideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ethoxzolamide.Withdrawn
Ethyl carbamateThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ethyl carbamate.Withdrawn
Ethyl chlorideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ethyl chloride.Experimental
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ethyl loflazepate.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Carfentanil.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Etidocaine.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Etifoxine.Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Etizolam.Approved
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Carfentanil.Approved
EtoperidoneCarfentanil may increase the serotonergic activities of Etoperidone.Approved
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Carfentanil.Illicit, Vet Approved
EtybenzatropineThe risk or severity of adverse effects can be increased when Etybenzatropine is combined with Carfentanil.Experimental
EzogabineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ezogabine.Approved
FelbamateThe risk or severity of adverse effects can be increased when Carfentanil is combined with Felbamate.Approved
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Carfentanil.Approved, Illicit, Withdrawn
FenquizoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Fenquizone.Experimental
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Carfentanil.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe risk or severity of adverse effects can be increased when Fesoterodine is combined with Carfentanil.Approved
FexofenadineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Fexofenadine.Approved
FlibanserinThe risk or severity of adverse effects can be increased when Carfentanil is combined with Flibanserin.Approved
FluanisoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Fluanisone.Experimental
FludiazepamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Fludiazepam.Approved, Illicit
FlunarizineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Flunarizine.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Flunitrazepam.Approved, Illicit
FluoxetineCarfentanil may increase the serotonergic activities of Fluoxetine.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Carfentanil.Approved, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Carfentanil.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Carfentanil.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Fluspirilene.Approved
Fluticasone propionateThe risk or severity of adverse effects can be increased when Carfentanil is combined with Fluticasone propionate.Approved
FluvoxamineThe risk or severity of adverse effects can be increased when Fluvoxamine is combined with Carfentanil.Approved, Investigational
FosphenytoinThe risk or severity of adverse effects can be increased when Carfentanil is combined with Fosphenytoin.Approved
FospropofolThe risk or severity of adverse effects can be increased when Carfentanil is combined with Fospropofol.Approved, Illicit
FurazolidoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Furazolidone.Approved, Vet Approved
FurosemideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Furosemide.Approved, Vet Approved
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Carfentanil.Approved, Investigational
Gabapentin EnacarbilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Gabapentin Enacarbil.Approved
GallamineThe risk or severity of adverse effects can be increased when Gallamine is combined with Carfentanil.Experimental
Gallamine TriethiodideThe risk or severity of adverse effects can be increased when Gallamine Triethiodide is combined with Carfentanil.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Carfentanil.Approved, Illicit
GepefrineGepefrine may increase the analgesic activities of Carfentanil.Experimental
GepironeThe risk or severity of adverse effects can be increased when Carfentanil is combined with Gepirone.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Carfentanil.Approved, Illicit
GlycopyrroniumThe risk or severity of adverse effects can be increased when Glycopyrronium is combined with Carfentanil.Approved, Investigational, Vet Approved
GuanfacineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Carfentanil.Approved, Illicit, Withdrawn
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Carfentanil.Approved
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Carfentanil.Approved, Vet Approved
HarmalineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Harmaline.Experimental
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Carfentanil.Approved, Illicit
HexamethoniumThe risk or severity of adverse effects can be increased when Hexamethonium is combined with Carfentanil.Experimental
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Carfentanil.Approved
HomatropineThe risk or severity of adverse effects can be increased when Homatropine is combined with Carfentanil.Approved
HydracarbazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Hydracarbazine.Experimental
HydrochlorothiazideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Hydrochlorothiazide.Approved, Vet Approved
HydrocodoneCarfentanil may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydroflumethiazideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Hydroflumethiazide.Approved
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Carfentanil.Approved, Illicit
HydroxyamphetamineHydroxyamphetamine may increase the analgesic activities of Carfentanil.Approved
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.Approved
HyoscyamineThe risk or severity of adverse effects can be increased when Hyoscyamine is combined with Carfentanil.Approved
IbopamineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ibopamine.Experimental
IloperidoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Iloperidone.Approved
ImipramineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Imipramine.Approved
IndalpineCarfentanil may increase the serotonergic activities of Indalpine.Investigational, Withdrawn
IndapamideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Indapamide.Approved
IndiplonThe risk or severity of adverse effects can be increased when Carfentanil is combined with Indiplon.Investigational
Iofetamine I-123Iofetamine I-123 may increase the analgesic activities of Carfentanil.Approved
Ipratropium bromideThe risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Carfentanil.Approved
IproclozideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Iproclozide.Withdrawn
IproniazidThe risk or severity of adverse effects can be increased when Carfentanil is combined with Iproniazid.Withdrawn
IsocarboxazidThe risk or severity of adverse effects can be increased when Carfentanil is combined with Isocarboxazid.Approved
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Carfentanil.Approved, Vet Approved
IsosorbideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Isosorbide.Approved
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Carfentanil.Approved, Vet Approved
KetazolamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ketazolam.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ketobemidone.Approved
LamotrigineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Lamotrigine.Approved, Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Levetiracetam.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Carfentanil.Approved
LevocabastineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Levocabastine.Approved
LevocetirizineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Levocetirizine.Approved
LevodopaThe risk or severity of adverse effects can be increased when Carfentanil is combined with Levodopa.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Carfentanil.Approved
LevomilnacipranCarfentanil may increase the serotonergic activities of Levomilnacipran.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Carfentanil.Approved
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Carfentanil.Approved, Vet Approved
LisdexamfetamineLisdexamfetamine may increase the analgesic activities of Carfentanil.Approved, Investigational
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Carfentanil.Approved
LofentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Lofentanil.Illicit
LoprazolamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Loprazolam.Experimental
LoratadineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Loratadine.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Carfentanil.Approved
LormetazepamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Lormetazepam.Approved
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Carfentanil.Approved
LurasidoneThe risk or severity of adverse effects can be increased when Lurasidone is combined with Carfentanil.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.Approved, Vet Approved
MannitolThe risk or severity of adverse effects can be increased when Carfentanil is combined with Mannitol.Approved, Investigational
MaprotilineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Maprotiline.Approved
MazaticolThe risk or severity of adverse effects can be increased when Mazaticol is combined with Carfentanil.Experimental
MebanazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Mebanazine.Withdrawn
MebicarThe risk or severity of adverse effects can be increased when Carfentanil is combined with Mebicar.Experimental
MebutizideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Mebutizide.Experimental
MecamylamineThe risk or severity of adverse effects can be increased when Mecamylamine is combined with Carfentanil.Approved
MeclizineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Meclizine.Approved
MedazepamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Medazepam.Experimental
MedetomidineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Medetomidine.Vet Approved
MefrusideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Mefruside.Experimental
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Carfentanil.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Melperone.Approved
MephedroneMephedrone may increase the analgesic activities of Carfentanil.Investigational
MephentermineMephentermine may increase the analgesic activities of Carfentanil.Approved
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Carfentanil.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Carfentanil.Approved, Illicit
MeptazinolThe risk or severity of adverse effects can be increased when Carfentanil is combined with Meptazinol.Experimental
MersalylThe risk or severity of adverse effects can be increased when Carfentanil is combined with Mersalyl.Approved
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Carfentanil.Approved
MetaxaloneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Metaxalone.Approved
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Carfentanil.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Carfentanil.Approved, Illicit
MethamphetamineMethamphetamine may increase the analgesic activities of Carfentanil.Approved, Illicit
MethanthelineThe risk or severity of adverse effects can be increased when Methantheline is combined with Carfentanil.Approved
MethapyrileneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Methapyrilene.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Methaqualone.Illicit, Withdrawn
MethazolamideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Methazolamide.Approved
MethocarbamolThe risk or severity of adverse effects can be increased when Carfentanil is combined with Methocarbamol.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Carfentanil.Approved
MethotrimeprazineCarfentanil may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Carfentanil.Approved, Vet Approved
MethoxyphenamineMethoxyphenamine may increase the analgesic activities of Carfentanil.Experimental
MethsuximideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Methsuximide.Approved
MethyclothiazideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Methyclothiazide.Approved
MethylecgonineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Methylecgonine.Experimental
Methylene blueMethylene blue may increase the hypotensive activities of Carfentanil.Investigational
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Carfentanil.Approved
MeticraneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Meticrane.Experimental
MetixeneThe risk or severity of adverse effects can be increased when Metixene is combined with Carfentanil.Approved
MetolazoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Metolazone.Approved
MetyrosineCarfentanil may increase the sedative activities of Metyrosine.Approved
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Carfentanil.Approved, Illicit
Midomafetamine3,4-Methylenedioxymethamphetamine may increase the analgesic activities of Carfentanil.Experimental, Illicit
MilnacipranCarfentanil may increase the serotonergic activities of Milnacipran.Approved
MinaprineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Minaprine.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.Approved, Investigational
MirtazapineCarfentanil may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MMDAMMDA may increase the analgesic activities of Carfentanil.Experimental, Illicit
MoclobemideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Moclobemide.Approved
MolindoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Molindone.Approved
MoricizineMoricizine may increase the hypotensive activities of Carfentanil.Approved, Withdrawn
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Carfentanil.Approved, Investigational
MuzolimineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Muzolimine.Experimental
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.Approved, Investigational
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Carfentanil.Approved
NaltrexoneThe therapeutic efficacy of Carfentanil can be decreased when used in combination with Naltrexone.Approved, Investigational, Vet Approved
NefazodoneCarfentanil may increase the serotonergic activities of Nefazodone.Approved, Withdrawn
NialamideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Nialamide.Withdrawn
NitrazepamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Carfentanil.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Carfentanil.Approved, Vet Approved
NorfluraneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Norflurane.Investigational
NormethadoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Normethadone.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Nortriptyline.Approved
OctamoxinThe risk or severity of adverse effects can be increased when Carfentanil is combined with Octamoxin.Withdrawn
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Carfentanil.Approved, Investigational
OlopatadineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Olopatadine.Approved
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Carfentanil.Approved
OpiumThe risk or severity of adverse effects can be increased when Carfentanil is combined with Opium.Approved, Illicit
OrphenadrineCarfentanil may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Carfentanil is combined with Osanetant.Investigational
OtiloniumThe risk or severity of adverse effects can be increased when Otilonium is combined with Carfentanil.Experimental
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Carfentanil.Approved
OxethazaineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Oxethazaine.Investigational
OxitropiumThe risk or severity of adverse effects can be increased when Oxitropium is combined with Carfentanil.Investigational
OxprenololThe risk or severity of adverse effects can be increased when Carfentanil is combined with Oxprenolol.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Carfentanil.Approved
OxybutyninThe risk or severity of adverse effects can be increased when Oxybutynin is combined with Carfentanil.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Carfentanil.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Carfentanil.Approved, Investigational, Vet Approved
OxyphenoniumThe risk or severity of adverse effects can be increased when Oxyphenonium is combined with Carfentanil.Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Carfentanil.Approved
PancuroniumThe risk or severity of adverse effects can be increased when Pancuronium is combined with Carfentanil.Approved
ParaldehydeCarfentanil may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
PargylineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Pargyline.Approved
ParoxetineCarfentanil may increase the serotonergic activities of Paroxetine.Approved, Investigational
PegvisomantThe therapeutic efficacy of Pegvisomant can be decreased when used in combination with Carfentanil.Approved
PenfluridolThe risk or severity of adverse effects can be increased when Carfentanil is combined with Penfluridol.Experimental
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Carfentanil.Approved, Vet Approved
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Carfentanil.Approved, Vet Approved
PentoliniumThe risk or severity of adverse effects can be increased when Pentolinium is combined with Carfentanil.Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.Approved
PerazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Perazine.Investigational
PerospironeThe risk or severity of adverse effects can be increased when Carfentanil is combined with Perospirone.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Carfentanil.Approved
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Carfentanil.Approved
PhenazocineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Phenazocine.Experimental
PhenelzineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Phenelzine.Approved
PhenglutarimideThe risk or severity of adverse effects can be increased when Phenglutarimide is combined with Carfentanil.Experimental
PhenibutThe risk or severity of adverse effects can be increased when Carfentanil is combined with Phenibut.Experimental
PheniprazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Pheniprazine.Withdrawn
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Carfentanil.Approved
PhenoperidineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Phenoperidine.Experimental
PhenoxyethanolThe risk or severity of adverse effects can be increased when Carfentanil is combined with Phenoxyethanol.Approved
PhenoxypropazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Phenoxypropazine.Withdrawn
PhenterminePhentermine may increase the analgesic activities of Carfentanil.Approved, Illicit
PhenytoinThe risk or severity of adverse effects can be increased when Carfentanil is combined with Phenytoin.Approved, Vet Approved
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Carfentanil.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Pipamperone.Approved
PipecuroniumThe risk or severity of adverse effects can be increased when Pipecuronium is combined with Carfentanil.Approved
PipotiazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Pipotiazine.Approved
PirenzepineThe risk or severity of adverse effects can be increased when Pirenzepine is combined with Carfentanil.Approved
PiretanideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Piretanide.Experimental
PiritramideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Piritramide.Investigational
PirlindoleThe risk or severity of adverse effects can be increased when Carfentanil is combined with Pirlindole.Approved
PivhydrazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Pivhydrazine.Withdrawn
PizotifenThe risk or severity of adverse effects can be increased when Carfentanil is combined with Pizotifen.Approved
PolythiazideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Polythiazide.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Pomalidomide.Approved
PotassiumThe risk or severity of adverse effects can be increased when Carfentanil is combined with Potassium.Approved
Potassium CitrateThe risk or severity of adverse effects can be increased when Carfentanil is combined with Potassium Citrate.Approved, Vet Approved
PramipexoleCarfentanil may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Pramocaine.Approved
PrazepamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Prazepam.Approved, Illicit
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Carfentanil.Approved, Illicit, Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Carfentanil.Approved
PrimidoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Primidone.Approved, Vet Approved
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Carfentanil.Approved, Investigational, Vet Approved
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Carfentanil.Approved, Vet Approved
ProcyclidineThe risk or severity of adverse effects can be increased when Procyclidine is combined with Carfentanil.Approved
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Carfentanil.Approved, Vet Approved
PromethazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Promethazine.Approved
PropanididThe risk or severity of adverse effects can be increased when Carfentanil is combined with Propanidid.Experimental
PropanthelineThe risk or severity of adverse effects can be increased when Propantheline is combined with Carfentanil.Approved
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Carfentanil.Approved, Vet Approved
PropiopromazinePropiopromazine may increase the hypotensive activities of Carfentanil.Vet Approved
PropiverineThe risk or severity of adverse effects can be increased when Propiverine is combined with Carfentanil.Investigational
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Carfentanil.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Propoxycaine.Approved
ProtriptylineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Protriptyline.Approved
ProxibarbalThe risk or severity of adverse effects can be increased when Carfentanil is combined with Proxibarbal.Experimental
PSD502The risk or severity of adverse effects can be increased when Carfentanil is combined with PSD502.Investigational
PseudoephedrinePseudoephedrine may increase the analgesic activities of Carfentanil.Approved
QuazepamThe risk or severity of adverse effects can be increased when Quazepam is combined with Carfentanil.Approved, Illicit
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Carfentanil.Approved
QuinethazoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Quinethazone.Approved
QuinidineThe risk or severity of adverse effects can be increased when Quinidine is combined with Carfentanil.Approved
QuinisocaineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Quinisocaine.Experimental
RacloprideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ramelteon.Approved, Investigational
RamosetronCarfentanil may increase the constipating activities of Ramosetron.Approved
RasagilineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Rasagiline.Approved
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Carfentanil.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Carfentanil.Approved, Withdrawn
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Carfentanil.Approved
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Carfentanil.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ritanserin.Investigational
RitobegronRitobegron may increase the analgesic activities of Carfentanil.Investigational
RolofyllineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Rolofylline.Investigational
RomifidineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Romifidine.Vet Approved
RopiniroleCarfentanil may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Carfentanil.Approved
RotigotineCarfentanil may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Carfentanil.Approved
SafrazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Safrazine.Withdrawn
ScopolamineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Scopolamine.Approved
Scopolamine butylbromideThe risk or severity of adverse effects can be increased when Scopolamine butylbromide is combined with Carfentanil.Approved, Vet Approved
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Carfentanil.Approved, Vet Approved
SelegilineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Selegiline.Approved, Investigational, Vet Approved
SepranoloneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Sepranolone.Investigational
SertindoleThe risk or severity of adverse effects can be increased when Carfentanil is combined with Sertindole.Approved, Withdrawn
SertralineCarfentanil may increase the serotonergic activities of Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Carfentanil.Approved, Vet Approved
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.Approved
SolifenacinThe risk or severity of adverse effects can be increased when Solifenacin is combined with Carfentanil.Approved
SpiradolineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Spiradoline.Investigational
SpironolactoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Spironolactone.Approved
StiripentolThe risk or severity of adverse effects can be increased when Carfentanil is combined with Stiripentol.Approved
SuccinylcholineSuccinylcholine may increase the bradycardic activities of Carfentanil.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Carfentanil.Approved, Investigational
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Carfentanil.Approved
SultoprideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Sultopride.Experimental
SuvorexantCarfentanil may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TandospironeThe risk or severity of adverse effects can be increased when Carfentanil is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Carfentanil is combined with Tasimelteon.Approved
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Carfentanil.Approved
TetrabenazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Tetrabenazine.Approved
TetracaineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Tetracaine.Approved, Vet Approved
TetrahydropalmatineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Tetrahydropalmatine.Investigational
TetrodotoxinThe risk or severity of adverse effects can be increased when Carfentanil is combined with Tetrodotoxin.Investigational
ThalidomideCarfentanil may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
TheobromineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Theobromine.Approved
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Carfentanil.Approved, Vet Approved
ThiazinamThiazinam may increase the hypotensive activities of Carfentanil.Experimental
ThiethylperazineThiethylperazine may increase the hypotensive activities of Carfentanil.Withdrawn
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Carfentanil.Approved, Vet Approved
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Carfentanil.Withdrawn
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Carfentanil.Approved
TiagabineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Tiagabine.Approved
TiaprideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Tiapride.Approved, Investigational
TicrynafenThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ticrynafen.Withdrawn
TiletamineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Tiletamine.Vet Approved
TilidineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Tilidine.Experimental
TiotropiumThe risk or severity of adverse effects can be increased when Tiotropium is combined with Carfentanil.Approved
TizanidineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Tizanidine.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Carfentanil is combined with Tolcapone.Approved, Withdrawn
ToloxatoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Toloxatone.Approved
TolterodineThe risk or severity of adverse effects can be increased when Tolterodine is combined with Carfentanil.Approved, Investigational
TolvaptanThe risk or severity of adverse effects can be increased when Carfentanil is combined with Tolvaptan.Approved
TopiramateThe risk or severity of adverse effects can be increased when Carfentanil is combined with Topiramate.Approved
TorasemideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Torasemide.Approved
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Carfentanil.Approved, Investigational
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Trans-2-Phenylcyclopropylamine.Experimental
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Carfentanil.Approved
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with Carfentanil.Approved, Investigational
TriamtereneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Triamterene.Approved
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Carfentanil.Approved
Tricaine methanesulfonateThe risk or severity of adverse effects can be increased when Carfentanil is combined with Tricaine methanesulfonate.Vet Approved
TrichlormethiazideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Trichlormethiazide.Approved, Vet Approved
TrichloroethyleneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Trichloroethylene.Experimental
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Carfentanil.Approved
TrifluperidolThe risk or severity of adverse effects can be increased when Carfentanil is combined with Trifluperidol.Experimental
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Carfentanil.Approved, Vet Approved
TrihexyphenidylThe risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Carfentanil.Approved
TrimethaphanThe risk or severity of adverse effects can be increased when Trimethaphan is combined with Carfentanil.Approved
TrimipramineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Trimipramine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Triprolidine.Approved
TropatepineThe risk or severity of adverse effects can be increased when Tropatepine is combined with Carfentanil.Experimental
TropicamideThe risk or severity of adverse effects can be increased when Tropicamide is combined with Carfentanil.Approved
TrospiumThe risk or severity of adverse effects can be increased when Trospium is combined with Carfentanil.Approved
TubocurarineThe risk or severity of adverse effects can be increased when Tubocurarine is combined with Carfentanil.Approved
UlaritideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ularitide.Investigational
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Carfentanil.Approved, Investigational
VecuroniumThe risk or severity of adverse effects can be increased when Vecuronium is combined with Carfentanil.Approved
VenlafaxineCarfentanil may increase the serotonergic activities of Venlafaxine.Approved
VeraliprideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Veralipride.Experimental
VigabatrinThe risk or severity of adverse effects can be increased when Carfentanil is combined with Vigabatrin.Approved
Vinyl etherThe risk or severity of adverse effects can be increased when Carfentanil is combined with Vinyl ether.Experimental
VortioxetineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Vortioxetine.Approved
XenonThe risk or severity of adverse effects can be increased when Carfentanil is combined with Xenon.Experimental
XipamideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Xipamide.Experimental
XylazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Xylazine.Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Carfentanil.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ziconotide.Approved
ZimelidineCarfentanil may increase the serotonergic activities of Zimelidine.Withdrawn
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Carfentanil.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Zolazepam.Vet Approved
ZolpidemCarfentanil may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Zonisamide.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Carfentanil.Approved
ZotepineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Zotepine.Approved
ZuclopenthixolThe risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Carfentanil.Approved, Investigational
Food Interactions
Not Available

References

Synthesis Reference

Louis P. Reiff, Paul B. Sollman, "Process of making carfentanil and related analgesics." U.S. Patent US5106983, issued January, 1981.

US5106983
General References
  1. Wax PM, Becker CE, Curry SC: Unexpected "gas" casualties in Moscow: a medical toxicology perspective. Ann Emerg Med. 2003 May;41(5):700-5. [PubMed:12712038 ]
External Links
PubChem Compound
62156
PubChem Substance
46505501
ChemSpider
55986
BindingDB
50012477
ChEBI
61084
ChEMBL
CHEMBL290429
Wikipedia
Carfentanil
ATC Codes
Not Available
AHFS Codes
Not Available
PDB Entries
Not Available
FDA label
Not Available
MSDS
Not Available

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedScreeningSubstance-related Discorder1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0259 mg/mLALOGPS
logP3.7ALOGPS
logP3.67ChemAxon
logS-4.2ALOGPS
pKa (Strongest Basic)8.05ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area49.85 Å2ChemAxon
Rotatable Bond Count8ChemAxon
Refractivity114.38 m3·mol-1ChemAxon
Polarizability44.6 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.8605
Blood Brain Barrier+0.9762
Caco-2 permeable-0.5069
P-glycoprotein substrateSubstrate0.7011
P-glycoprotein inhibitor IInhibitor0.8424
P-glycoprotein inhibitor IINon-inhibitor0.6298
Renal organic cation transporterNon-inhibitor0.6504
CYP450 2C9 substrateNon-substrate0.8368
CYP450 2D6 substrateNon-substrate0.8791
CYP450 3A4 substrateSubstrate0.6667
CYP450 1A2 substrateNon-inhibitor0.9279
CYP450 2C9 inhibitorNon-inhibitor0.7664
CYP450 2D6 inhibitorNon-inhibitor0.8561
CYP450 2C19 inhibitorNon-inhibitor0.7325
CYP450 3A4 inhibitorNon-inhibitor0.6284
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.6023
Ames testNon AMES toxic0.7779
CarcinogenicityNon-carcinogens0.869
BiodegradationNot ready biodegradable0.9474
Rat acute toxicity2.9219 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9613
hERG inhibition (predictor II)Inhibitor0.6716
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of chemical entities known as fentanyls. These are compounds containing the fentanyl moiety or a derivative, which is based on a N-(1-(2-phenylethyl)-4-piperidinyl)-N-phenylpropanamide skeleton.
Kingdom
Chemical entities
Super Class
Organic compounds
Class
Organoheterocyclic compounds
Sub Class
Piperidines
Direct Parent
Fentanyls
Alternative Parents
Alpha amino acids and derivatives / Piperidinecarboxylic acids / Phenethylamines / Anilides / Aralkylamines / Tertiary carboxylic acid amides / Methyl esters / Trialkylamines / Monocarboxylic acids and derivatives / Azacyclic compounds
show 4 more
Substituents
Fentanyl / Alpha-amino acid or derivatives / Phenethylamine / Piperidinecarboxylic acid / Anilide / Aralkylamine / Benzenoid / Monocyclic benzene moiety / Methyl ester / Tertiary carboxylic acid amide
show 18 more
Molecular Framework
Aromatic heteromonocyclic compounds
External Descriptors
piperidines, tertiary amino compound, methyl ester, carboxamide (CHEBI:61084 )

Targets

Details
1. Mu-type opioid receptor
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Agonist
General Function
Voltage-gated calcium channel activity
Specific Function
Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone...
Gene Name
OPRM1
Uniprot ID
P35372
Uniprot Name
Mu-type opioid receptor
Molecular Weight
44778.855 Da
References
  1. Bencherif B, Wand GS, McCaul ME, Kim YK, Ilgin N, Dannals RF, Frost JJ: Mu-opioid receptor binding measured by [11C]carfentanil positron emission tomography is related to craving and mood in alcohol dependence. Biol Psychiatry. 2004 Feb 1;55(3):255-62. [PubMed:14744466 ]
  2. Bencherif B, Stumpf MJ, Links JM, Frost JJ: Application of MRI-based partial-volume correction to the analysis of PET images of mu-opioid receptors using statistical parametric mapping. J Nucl Med. 2004 Mar;45(3):402-8. [PubMed:15001679 ]
  3. Jewett DM, Kilbourn MR: In vivo evaluation of new carfentanil-based radioligands for the mu opiate receptor. Nucl Med Biol. 2004 Apr;31(3):321-5. [PubMed:15028244 ]
  4. Mayberg HS, Sadzot B, Meltzer CC, Fisher RS, Lesser RP, Dannals RF, Lever JR, Wilson AA, Ravert HT, Wagner HN Jr, et al.: Quantification of mu and non-mu opiate receptors in temporal lobe epilepsy using positron emission tomography. Ann Neurol. 1991 Jul;30(1):3-11. [PubMed:1656846 ]
  5. Bartenstein PA, Prevett MC, Duncan JS, Hajek M, Wieser HG: Quantification of opiate receptors in two patients with mesiobasal temporal lobe epilepsy, before and after selective amygdalohippocampectomy, using positron emission tomography. Epilepsy Res. 1994 Jun;18(2):119-25. [PubMed:7957034 ]
Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Agonist
General Function
Opioid receptor activity
Specific Function
G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine n...
Gene Name
OPRD1
Uniprot ID
P41143
Uniprot Name
Delta-type opioid receptor
Molecular Weight
40368.235 Da
References
  1. Mayberg HS, Sadzot B, Meltzer CC, Fisher RS, Lesser RP, Dannals RF, Lever JR, Wilson AA, Ravert HT, Wagner HN Jr, et al.: Quantification of mu and non-mu opiate receptors in temporal lobe epilepsy using positron emission tomography. Ann Neurol. 1991 Jul;30(1):3-11. [PubMed:1656846 ]
  2. Barry U, Zuo Z: Opioids: old drugs for potential new applications. Curr Pharm Des. 2005;11(10):1343-50. [PubMed:15853689 ]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Agonist
General Function
Opioid receptor activity
Specific Function
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synt...
Gene Name
OPRK1
Uniprot ID
P41145
Uniprot Name
Kappa-type opioid receptor
Molecular Weight
42644.665 Da
References
  1. Mayberg HS, Sadzot B, Meltzer CC, Fisher RS, Lesser RP, Dannals RF, Lever JR, Wilson AA, Ravert HT, Wagner HN Jr, et al.: Quantification of mu and non-mu opiate receptors in temporal lobe epilepsy using positron emission tomography. Ann Neurol. 1991 Jul;30(1):3-11. [PubMed:1656846 ]
  2. Barry U, Zuo Z: Opioids: old drugs for potential new applications. Curr Pharm Des. 2005;11(10):1343-50. [PubMed:15853689 ]

Drug created on July 31, 2007 07:10 / Updated on October 02, 2017 05:00