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Identification
NameCarfentanil
Accession NumberDB01535
TypeSmall Molecule
GroupsIllicit, Vet Approved
DescriptionCarfentanil or carfentanyl (Wildnil) is an analogue of the popular synthetic opioid analgesic fentanyl, and is one of the most potent opioids known (also the most potent opioid used commercially). Carfentanil was first synthesized in 1974 by a team of chemists at Janssen Pharmaceutica which included Paul Janssen. It has a quantitative potency approximately 10,000 times that of morphine and 100 times that of fentanyl, with activity in humans starting at about 1 microgram. It is marketed under the trade name Wildnil as a general anaesthetic agent for large animals. Carfentanil is intended for large-animal use only as its extreme potency makes it inappropriate for use in humans. Currently sufentanil, approximately 10–20 times less potent (500 to 1000 times the efficacy of morphine per weight) than carfentanil, is the maximum strength fentanyl analog for use in humans.
Structure
Thumb
Synonyms
Carfentanyl
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International BrandsNot Available
Brand mixturesNot Available
Salts
Name/CASStructureProperties
Carfentanil citrate
ThumbNot applicableDBSALT001611
Categories
UNIILA9DTA2L8F
CAS number59708-52-0
WeightAverage: 394.5066
Monoisotopic: 394.225642836
Chemical FormulaC24H30N2O3
InChI KeyYDSDEBIZUNNPOB-UHFFFAOYSA-N
InChI
InChI=1S/C24H30N2O3/c1-3-22(27)26(21-12-8-5-9-13-21)24(23(28)29-2)15-18-25(19-16-24)17-14-20-10-6-4-7-11-20/h4-13H,3,14-19H2,1-2H3
IUPAC Name
methyl 1-(2-phenylethyl)-4-(N-phenylpropanamido)piperidine-4-carboxylate
SMILES
CCC(=O)N(C1=CC=CC=C1)C1(CCN(CCC2=CC=CC=C2)CC1)C(=O)OC
Pharmacology
IndicationCarfentanil is similar (but more potent) to the opioid analgesic fentanyl. It is used as a tranquilizer for large animals.
Structured Indications Not Available
PharmacodynamicsCarfentanil acts primarily on the mu (some kappa and delta) opioid receptors as an agonist. It will induce similar effects of analgesia as other opioids, however, due to its potency, it will also induce strong side effects such as sedation. Consequently, that is why it is used as a tranquilizer for large animals. Carfentanil interacts predominately with the opioid mu-receptor. These mu-binding sites are discretely distributed in the brain, spinal cord, and other tissues. It exerts its principal pharmacologic effects on the central nervous system. Its primary actions of therapeutic value are analgesia and sedation. Carfentanil also depresses the respiratory centers, depresses the cough reflex, and constricts the pupils.
Mechanism of actionCarfentanil binds very strongly to mu opioid receptors and acts as a competitive agonist. Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.
TargetKindPharmacological actionActionsOrganismUniProt ID
Mu-type opioid receptorProteinyes
agonist
HumanP35372 details
Delta-type opioid receptorProteinyes
agonist
HumanP41143 details
Kappa-type opioid receptorProteinunknown
agonist
HumanP41145 details
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
MetabolismNot Available
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityNot Available
Affected organismsNot Available
Pathways
PathwayCategorySMPDB ID
Carfentanil Action PathwayDrug actionSMP00414
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
1,1,1,2 TetrafluoroethaneThe risk or severity of adverse effects can be increased when Carfentanil is combined with 1,1,1,2 Tetrafluoroethane.Investigational
2,5-Dimethoxy-4-ethylamphetamine2,5-Dimethoxy-4-ethylamphetamine may increase the analgesic activities of Carfentanil.Experimental, Illicit
3,4-Methylenedioxyamphetamine3,4-Methylenedioxyamphetamine may increase the analgesic activities of Carfentanil.Experimental, Illicit
3,4-Methylenedioxymethamphetamine3,4-Methylenedioxymethamphetamine may increase the analgesic activities of Carfentanil.Experimental, Illicit
4-Bromo-2,5-dimethoxyamphetamine4-Bromo-2,5-dimethoxyamphetamine may increase the analgesic activities of Carfentanil.Experimental, Illicit
7-NitroindazoleThe risk or severity of adverse effects can be increased when Carfentanil is combined with 7-Nitroindazole.Experimental
AcepromazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Acepromazine.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Aceprometazine.Approved
AcetazolamideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Acetazolamide.Approved, Vet Approved
AclidiniumThe risk or severity of adverse effects can be increased when Aclidinium is combined with Carfentanil.Approved
adipiplonThe risk or severity of adverse effects can be increased when Carfentanil is combined with adipiplon.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Agomelatine.Approved, Investigational
AlfaxaloneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Alfaxalone.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Carfentanil.Approved, Illicit
AlimemazineAlimemazine may increase the hypotensive activities of Carfentanil.Approved, Vet Approved
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Carfentanil is combined with Alphacetylmethadol.Experimental, Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Carfentanil.Approved, Illicit, Investigational
AlvimopanThe risk or severity of adverse effects can be increased when Carfentanil is combined with Alvimopan.Approved
AmilorideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Amiloride.Approved
AmisulprideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Amisulpride.Approved, Investigational
AmitriptylineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Amitriptyline.Approved
Ammonium chlorideAmmonium chloride may increase the excretion rate of Carfentanil which could result in a lower serum level and potentially a reduction in efficacy.Approved, Vet Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Carfentanil.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Amoxapine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Amperozide.Experimental
AmphetamineAmphetamine may increase the analgesic activities of Carfentanil.Approved, Illicit
Anisotropine MethylbromideThe risk or severity of adverse effects can be increased when Anisotropine Methylbromide is combined with Carfentanil.Approved
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Carfentanil.Approved, Investigational
ArticaineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Articaine.Approved
AsenapineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Asenapine.Approved
Atracurium besylateThe risk or severity of adverse effects can be increased when Atracurium besylate is combined with Carfentanil.Approved
AtropineThe risk or severity of adverse effects can be increased when Atropine is combined with Carfentanil.Approved, Vet Approved
AzaperoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Azaperone.Vet Approved
AzelastineCarfentanil may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
AzelastineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Azelastine.Approved
AzosemideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Azosemide.Investigational
BaclofenThe risk or severity of adverse effects can be increased when Carfentanil is combined with Baclofen.Approved
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Carfentanil.Illicit
BenactyzineThe risk or severity of adverse effects can be increased when Benactyzine is combined with Carfentanil.Withdrawn
BendroflumethiazideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Bendroflumethiazide.Approved
BenperidolThe risk or severity of adverse effects can be increased when Carfentanil is combined with Benperidol.Investigational
BenzatropineThe risk or severity of adverse effects can be increased when Benzatropine is combined with Carfentanil.Approved
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Carfentanil.Approved
BenzphetamineBenzphetamine may increase the analgesic activities of Carfentanil.Approved, Illicit
Benzyl alcoholThe risk or severity of adverse effects can be increased when Carfentanil is combined with Benzyl alcohol.Approved
BiperidenThe risk or severity of adverse effects can be increased when Biperiden is combined with Carfentanil.Approved
BL-1020BL-1020 may increase the hypotensive activities of Carfentanil.Investigational
BrexpiprazoleThe risk or severity of adverse effects can be increased when Carfentanil is combined with Brexpiprazole.Approved
BrimonidineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Brimonidine.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.Approved
BromazepamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Bromazepam.Approved, Illicit
BrompheniramineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Brompheniramine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Brotizolam.Approved, Withdrawn
BumetanideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Bumetanide.Approved
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Carfentanil.Approved, Investigational
BuprenorphineCarfentanil may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Carfentanil.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Carfentanil.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Butacaine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Carfentanil is combined with Butalbital.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Carfentanil is combined with Butamben.Approved
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Carfentanil.Approved, Illicit
ButorphanolButorphanol may decrease the analgesic activities of Carfentanil.Approved, Illicit, Vet Approved
Canrenoic acidThe risk or severity of adverse effects can be increased when Carfentanil is combined with Canrenoic acid.Approved, Withdrawn
CanrenoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Canrenone.Investigational
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Carfentanil.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Carbinoxamine.Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Carfentanil is combined with Carisoprodol.Approved
CetirizineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Cetirizine.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Carfentanil is combined with Chloral hydrate.Approved, Illicit, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Carfentanil.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Carfentanil.Approved, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Carfentanil.Approved
ChlorothiazideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Chlorothiazide.Approved, Vet Approved
ChlorphenamineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Chlorphenamine.Approved
ChlorphenoxamineThe risk or severity of adverse effects can be increased when Chlorphenoxamine is combined with Carfentanil.Withdrawn
ChlorphentermineChlorphentermine may increase the analgesic activities of Carfentanil.Illicit, Withdrawn
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Carfentanil.Approved, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Carfentanil.Approved, Withdrawn
ChlorthalidoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Chlorthalidone.Approved
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Chlorzoxazone.Approved
CicletanineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Cicletanine.Investigational
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Carfentanil.Approved, Vet Approved
CitalopramCarfentanil may increase the serotonergic activities of Citalopram.Approved
ClemastineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Clemastine.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Carfentanil is combined with Clidinium.Approved
ClobazamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Clobazam.Approved, Illicit
clomethiazoleThe risk or severity of adverse effects can be increased when Carfentanil is combined with clomethiazole.Investigational
ClomipramineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Clomipramine.Approved, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Clonazepam.Approved, Illicit
ClonidineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Clonidine.Approved
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Carfentanil.Approved, Illicit
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Carfentanil.Approved
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Carfentanil.Approved, Illicit
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Carfentanil.Approved, Illicit
ConivaptanThe risk or severity of adverse effects can be increased when Carfentanil is combined with Conivaptan.Approved, Investigational
CyclizineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Cyclizine.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Carfentanil.Approved
CyclopentolateThe risk or severity of adverse effects can be increased when Cyclopentolate is combined with Carfentanil.Approved
CyclothiazideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Cyclothiazide.Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Cyproheptadine.Approved
DantroleneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Dantrolene.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Carfentanil.Approved
DapoxetineCarfentanil may increase the serotonergic activities of Dapoxetine.Investigational
DarifenacinThe risk or severity of adverse effects can be increased when Darifenacin is combined with Carfentanil.Approved, Investigational
deramciclaneThe risk or severity of adverse effects can be increased when Carfentanil is combined with deramciclane.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Carfentanil.Approved
DesipramineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Desipramine.Approved
DesloratadineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Desloratadine.Approved, Investigational
DesmopressinThe risk or severity of adverse effects can be increased when Carfentanil is combined with Desmopressin.Approved
DesvenlafaxineCarfentanil may increase the serotonergic activities of Desvenlafaxine.Approved
DetomidineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Detomidine.Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Dexbrompheniramine.Approved
DexetimideThe risk or severity of adverse effects can be increased when Dexetimide is combined with Carfentanil.Withdrawn
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Carfentanil.Approved, Vet Approved
DextroamphetamineDextroamphetamine may increase the analgesic activities of Carfentanil.Approved, Illicit
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Carfentanil.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Carfentanil.Approved, Illicit, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Carfentanil.Approved
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Carfentanil.Approved, Illicit, Vet Approved
DicyclomineThe risk or severity of adverse effects can be increased when Dicyclomine is combined with Carfentanil.Approved
DiethylpropionDiethylpropion may increase the analgesic activities of Carfentanil.Approved, Illicit
DifenoxinThe risk or severity of adverse effects can be increased when Carfentanil is combined with Difenoxin.Approved, Illicit
DihydrocodeineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Dihydrocodeine.Approved, Illicit
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Carfentanil.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Dihydromorphine.Experimental, Illicit
DimenhydrinateThe risk or severity of adverse effects can be increased when Carfentanil is combined with Dimenhydrinate.Approved
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Carfentanil.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Carfentanil.Approved, Illicit
DoramectinThe risk or severity of adverse effects can be increased when Carfentanil is combined with Doramectin.Vet Approved
DoxepinThe risk or severity of adverse effects can be increased when Carfentanil is combined with Doxepin.Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when Carfentanil is combined with DPDPE.Investigational
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.Approved, Illicit
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.Approved, Vet Approved
DrospirenoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Drospirenone.Approved
DrotebanolThe risk or severity of adverse effects can be increased when Carfentanil is combined with Drotebanol.Experimental, Illicit
DuloxetineCarfentanil may increase the serotonergic activities of Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Carfentanil.Approved
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Carfentanil.Experimental, Illicit
ECGONINE METHYL ESTERThe risk or severity of adverse effects can be increased when Carfentanil is combined with ECGONINE METHYL ESTER.Experimental
EcopipamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ecopipam.Investigational
EfavirenzThe risk or severity of adverse effects can be increased when Carfentanil is combined with Efavirenz.Approved, Investigational
EfonidipineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Efonidipine.Approved
EluxadolineCarfentanil may increase the constipating activities of Eluxadoline.Approved
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Carfentanil.Approved, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Carfentanil is combined with Entacapone.Approved, Investigational
EplerenoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Eplerenone.Approved
EscitalopramCarfentanil may increase the serotonergic activities of Escitalopram.Approved, Investigational
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Carfentanil.Approved, Illicit
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Carfentanil.Approved
Etacrynic acidThe risk or severity of adverse effects can be increased when Carfentanil is combined with Etacrynic acid.Approved
EthanolCarfentanil may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Carfentanil.Approved, Illicit, Withdrawn
EthopropazineThe risk or severity of adverse effects can be increased when Ethopropazine is combined with Carfentanil.Approved
EthosuximideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ethosuximide.Approved
EthotoinThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ethotoin.Approved
EthoxzolamideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ethoxzolamide.Withdrawn
Ethyl carbamateThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ethyl carbamate.Withdrawn
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ethyl loflazepate.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Carfentanil.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Etidocaine.Approved
EtifoxineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Etifoxine.Withdrawn
EtizolamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Etizolam.Approved
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Carfentanil.Approved
EtoperidoneCarfentanil may increase the serotonergic activities of Etoperidone.Approved
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Carfentanil.Illicit, Vet Approved
EzogabineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ezogabine.Approved
FelbamateThe risk or severity of adverse effects can be increased when Carfentanil is combined with Felbamate.Approved
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Carfentanil.Approved, Illicit, Withdrawn
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Carfentanil.Approved, Illicit, Investigational, Vet Approved
FesoterodineThe risk or severity of adverse effects can be increased when Fesoterodine is combined with Carfentanil.Approved
FexofenadineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Fexofenadine.Approved
FlibanserinThe risk or severity of adverse effects can be increased when Carfentanil is combined with Flibanserin.Approved
FludiazepamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Fludiazepam.Approved, Illicit
FlunarizineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Flunarizine.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Flunitrazepam.Approved, Illicit
FluoxetineCarfentanil may increase the serotonergic activities of Fluoxetine.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Carfentanil.Approved, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Carfentanil.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Carfentanil.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Fluspirilene.Approved
Fluticasone PropionateThe risk or severity of adverse effects can be increased when Carfentanil is combined with Fluticasone Propionate.Approved
FluvoxamineThe risk or severity of adverse effects can be increased when Fluvoxamine is combined with Carfentanil.Approved, Investigational
FosphenytoinThe risk or severity of adverse effects can be increased when Carfentanil is combined with Fosphenytoin.Approved
FospropofolThe risk or severity of adverse effects can be increased when Carfentanil is combined with Fospropofol.Approved, Illicit
FurosemideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Furosemide.Approved, Vet Approved
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Carfentanil.Approved, Investigational
gabapentin enacarbilThe risk or severity of adverse effects can be increased when Carfentanil is combined with gabapentin enacarbil.Approved
Gallamine TriethiodideThe risk or severity of adverse effects can be increased when Gallamine Triethiodide is combined with Carfentanil.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Carfentanil.Approved, Illicit
GepironeThe risk or severity of adverse effects can be increased when Carfentanil is combined with Gepirone.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Carfentanil.Approved, Illicit
GlycopyrroniumThe risk or severity of adverse effects can be increased when Glycopyrronium is combined with Carfentanil.Approved, Investigational, Vet Approved
GuanfacineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Carfentanil.Approved, Illicit, Withdrawn
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Carfentanil.Approved
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Carfentanil.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Carfentanil.Approved, Illicit
HexamethoniumThe risk or severity of adverse effects can be increased when Hexamethonium is combined with Carfentanil.Experimental
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Carfentanil.Approved
HomatropineThe risk or severity of adverse effects can be increased when Homatropine is combined with Carfentanil.Approved
HydrochlorothiazideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Hydrochlorothiazide.Approved, Vet Approved
HydrocodoneCarfentanil may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydroflumethiazideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Hydroflumethiazide.Approved
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Carfentanil.Approved, Illicit
Hydroxyamphetamine hydrobromideHydroxyamphetamine hydrobromide may increase the analgesic activities of Carfentanil.Approved
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.Approved
HyoscyamineThe risk or severity of adverse effects can be increased when Hyoscyamine is combined with Carfentanil.Approved
IloperidoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Iloperidone.Approved
ImipramineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Imipramine.Approved
IndalpineCarfentanil may increase the serotonergic activities of Indalpine.Investigational, Withdrawn
IndapamideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Indapamide.Approved
Ipratropium bromideThe risk or severity of adverse effects can be increased when Ipratropium bromide is combined with Carfentanil.Approved
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Carfentanil.Approved, Vet Approved
IsosorbideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Isosorbide.Approved
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Carfentanil.Approved, Vet Approved
KetazolamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ketazolam.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ketobemidone.Approved
KW-3902The risk or severity of adverse effects can be increased when Carfentanil is combined with KW-3902.Investigational
LamotrigineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Lamotrigine.Approved, Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Levetiracetam.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Carfentanil.Approved
LevocabastineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Levocabastine.Approved
LevocetirizineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Levocetirizine.Approved
LevodopaThe risk or severity of adverse effects can be increased when Carfentanil is combined with Levodopa.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Carfentanil.Approved
LevomilnacipranCarfentanil may increase the serotonergic activities of Levomilnacipran.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Carfentanil.Approved
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Carfentanil.Approved, Vet Approved
LisdexamfetamineLisdexamfetamine may increase the analgesic activities of Carfentanil.Approved, Investigational
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Carfentanil.Approved
LofentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Lofentanil.Illicit
LoratadineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Loratadine.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Carfentanil.Approved
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Carfentanil.Approved
Lu AA21004The risk or severity of adverse effects can be increased when Carfentanil is combined with Lu AA21004.Investigational
LurasidoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Lurasidone.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.Approved, Vet Approved
MannitolThe risk or severity of adverse effects can be increased when Carfentanil is combined with Mannitol.Approved, Investigational
MaprotilineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Maprotiline.Approved
MecamylamineThe risk or severity of adverse effects can be increased when Mecamylamine is combined with Carfentanil.Approved
MeclizineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Meclizine.Approved
MedetomidineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Medetomidine.Vet Approved
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Carfentanil.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Melperone.Approved
MephedroneMephedrone may increase the analgesic activities of Carfentanil.Investigational
MephentermineMephentermine may increase the analgesic activities of Carfentanil.Approved
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Carfentanil.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Carfentanil.Approved, Illicit
MersalylThe risk or severity of adverse effects can be increased when Carfentanil is combined with Mersalyl.Approved
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Carfentanil.Approved
MetaxaloneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Metaxalone.Approved
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Carfentanil.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Carfentanil.Approved, Illicit
MethamphetamineMethamphetamine may increase the analgesic activities of Carfentanil.Approved, Illicit
MethanthelineThe risk or severity of adverse effects can be increased when Methantheline is combined with Carfentanil.Approved
MethapyrileneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Methapyrilene.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Methaqualone.Illicit, Withdrawn
MethazolamideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Methazolamide.Approved
MethocarbamolThe risk or severity of adverse effects can be increased when Carfentanil is combined with Methocarbamol.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Carfentanil.Approved
MethotrimeprazineCarfentanil may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Carfentanil.Approved, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Methsuximide.Approved
MethyclothiazideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Methyclothiazide.Approved
Methylene blueMethylene blue may increase the hypotensive activities of Carfentanil.Investigational
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Carfentanil.Approved
MetixeneThe risk or severity of adverse effects can be increased when Metixene is combined with Carfentanil.Approved
MetolazoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Metolazone.Approved
MetyrosineCarfentanil may increase the sedative activities of Metyrosine.Approved
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Carfentanil.Approved, Illicit
MilnacipranCarfentanil may increase the serotonergic activities of Milnacipran.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.Approved, Investigational
MirtazapineCarfentanil may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MMDAMMDA may increase the analgesic activities of Carfentanil.Experimental, Illicit
MolindoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Molindone.Approved
MoricizineMoricizine may increase the hypotensive activities of Carfentanil.Approved, Withdrawn
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Carfentanil.Approved, Investigational
N-butylscopolammonium bromideThe risk or severity of adverse effects can be increased when N-butylscopolammonium bromide is combined with Carfentanil.Vet Approved
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.Approved, Investigational
NalbuphineNalbuphine may decrease the analgesic activities of Carfentanil.Approved
NaltrexoneThe therapeutic efficacy of Carfentanil can be decreased when used in combination with Naltrexone.Approved, Investigational, Vet Approved
NefazodoneCarfentanil may increase the serotonergic activities of Nefazodone.Approved, Withdrawn
NitrazepamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Nitrazepam.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Nitrous oxide.Approved, Vet Approved
NormethadoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Normethadone.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Nortriptyline.Approved
NVA237The risk or severity of adverse effects can be increased when NVA237 is combined with Carfentanil.Investigational
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Carfentanil.Approved, Investigational
OlopatadineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Olopatadine.Approved
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Carfentanil.Approved
OpiumThe risk or severity of adverse effects can be increased when Carfentanil is combined with Opium.Approved, Illicit
OrphenadrineCarfentanil may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Carfentanil is combined with Osanetant.Investigational
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Carfentanil.Approved
OxetacaineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Oxetacaine.Investigational
OxprenololThe risk or severity of adverse effects can be increased when Carfentanil is combined with Oxprenolol.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Carfentanil.Approved
OxybutyninThe risk or severity of adverse effects can be increased when Oxybutynin is combined with Carfentanil.Approved, Investigational
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Carfentanil.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Carfentanil.Approved, Investigational, Vet Approved
OxyphenoniumThe risk or severity of adverse effects can be increased when Oxyphenonium is combined with Carfentanil.Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Carfentanil.Approved
PancuroniumThe risk or severity of adverse effects can be increased when Pancuronium is combined with Carfentanil.Approved
ParaldehydeCarfentanil may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ParoxetineCarfentanil may increase the serotonergic activities of Paroxetine.Approved, Investigational
PegvisomantThe therapeutic efficacy of Pegvisomant can be decreased when used in combination with Carfentanil.Approved
PentazocinePentazocine may decrease the analgesic activities of Carfentanil.Approved, Vet Approved
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Carfentanil.Approved, Vet Approved
PentoliniumThe risk or severity of adverse effects can be increased when Pentolinium is combined with Carfentanil.Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.Approved
PerazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Perazine.Investigational
PerospironeThe risk or severity of adverse effects can be increased when Carfentanil is combined with Perospirone.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Carfentanil.Approved
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Carfentanil.Approved
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Carfentanil.Approved
PhenoxyethanolThe risk or severity of adverse effects can be increased when Carfentanil is combined with Phenoxyethanol.Approved
PhenterminePhentermine may increase the analgesic activities of Carfentanil.Approved, Illicit
PhenytoinThe risk or severity of adverse effects can be increased when Carfentanil is combined with Phenytoin.Approved, Vet Approved
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Carfentanil.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Pipamperone.Approved
PipecuroniumThe risk or severity of adverse effects can be increased when Pipecuronium is combined with Carfentanil.Approved
PipotiazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Pipotiazine.Approved
PirenzepineThe risk or severity of adverse effects can be increased when Pirenzepine is combined with Carfentanil.Approved
PiretanideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Piretanide.Experimental
PiritramideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Piritramide.Investigational
PizotifenThe risk or severity of adverse effects can be increased when Carfentanil is combined with Pizotifen.Approved
PolythiazideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Polythiazide.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Pomalidomide.Approved
PotassiumThe risk or severity of adverse effects can be increased when Carfentanil is combined with Potassium.Approved
Potassium CitrateThe risk or severity of adverse effects can be increased when Carfentanil is combined with Potassium Citrate.Approved, Vet Approved
PramipexoleCarfentanil may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Pramocaine.Approved
PrazepamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Prazepam.Approved, Illicit
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Carfentanil.Approved, Illicit, Investigational
PregnanoloneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Pregnanolone.Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Carfentanil.Approved
PrimidoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Primidone.Approved, Vet Approved
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Carfentanil.Approved, Investigational, Vet Approved
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Carfentanil.Approved, Vet Approved
ProcyclidineThe risk or severity of adverse effects can be increased when Procyclidine is combined with Carfentanil.Approved
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Carfentanil.Approved, Vet Approved
PromethazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Promethazine.Approved
PropanthelineThe risk or severity of adverse effects can be increased when Propantheline is combined with Carfentanil.Approved
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Carfentanil.Approved, Vet Approved
PropiopromazinePropiopromazine may increase the hypotensive activities of Carfentanil.Vet Approved
PropiverineThe risk or severity of adverse effects can be increased when Propiverine is combined with Carfentanil.Investigational
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Carfentanil.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Propoxycaine.Approved
ProtriptylineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Protriptyline.Approved
PSD502The risk or severity of adverse effects can be increased when Carfentanil is combined with PSD502.Investigational
PseudoephedrinePseudoephedrine may increase the analgesic activities of Carfentanil.Approved
QuazepamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Quazepam.Approved, Illicit
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Carfentanil.Approved
QuinethazoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Quinethazone.Approved
QuinidineThe risk or severity of adverse effects can be increased when Quinidine is combined with Carfentanil.Approved
RacloprideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ramelteon.Approved, Investigational
RamosetronCarfentanil may increase the constipating activities of Ramosetron.Approved
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Carfentanil.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Carfentanil.Approved, Withdrawn
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Carfentanil.Approved
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Carfentanil.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ritanserin.Investigational
RitobegronRitobegron may increase the analgesic activities of Carfentanil.Investigational
RolofyllineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Rolofylline.Investigational
RomifidineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Romifidine.Vet Approved
RopiniroleCarfentanil may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Carfentanil.Approved
RotigotineCarfentanil may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Carfentanil.Approved
S-EthylisothioureaThe risk or severity of adverse effects can be increased when Carfentanil is combined with S-Ethylisothiourea.Experimental
Sage 547The risk or severity of adverse effects can be increased when Carfentanil is combined with Sage 547.Investigational
ScopolamineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Scopolamine.Approved
Scopolamine butylbromideThe risk or severity of adverse effects can be increased when Scopolamine butylbromide is combined with Carfentanil.Approved
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Carfentanil.Approved, Vet Approved
SertindoleThe risk or severity of adverse effects can be increased when Carfentanil is combined with Sertindole.Approved, Withdrawn
SertralineCarfentanil may increase the serotonergic activities of Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Carfentanil.Approved, Vet Approved
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.Approved
SolifenacinThe risk or severity of adverse effects can be increased when Solifenacin is combined with Carfentanil.Approved
SpironolactoneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Spironolactone.Approved
StiripentolThe risk or severity of adverse effects can be increased when Carfentanil is combined with Stiripentol.Approved
SuccinylcholineSuccinylcholine may increase the bradycardic activities of Carfentanil.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Carfentanil.Approved, Investigational
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Carfentanil.Approved
SuvorexantCarfentanil may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TandospironeThe risk or severity of adverse effects can be increased when Carfentanil is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Carfentanil.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Carfentanil is combined with Tasimelteon.Approved
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Carfentanil.Approved
TetrabenazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Tetrabenazine.Approved
TetracaineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Tetracaine.Approved, Vet Approved
TetrodotoxinThe risk or severity of adverse effects can be increased when Carfentanil is combined with Tetrodotoxin.Investigational
ThalidomideCarfentanil may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
TheobromineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Theobromine.Approved
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Carfentanil.Approved, Vet Approved
ThiethylperazineThiethylperazine may increase the hypotensive activities of Carfentanil.Withdrawn
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Carfentanil.Approved, Vet Approved
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Carfentanil.Approved
ThiothixeneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Thiothixene.Approved
TiagabineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Tiagabine.Approved
TiaprideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Tiapride.Investigational
TicrynafenThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ticrynafen.Withdrawn
TiletamineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Tiletamine.Vet Approved
TiotropiumThe risk or severity of adverse effects can be increased when Tiotropium is combined with Carfentanil.Approved
TizanidineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Tizanidine.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Carfentanil is combined with Tolcapone.Approved, Withdrawn
TolterodineThe risk or severity of adverse effects can be increased when Tolterodine is combined with Carfentanil.Approved, Investigational
TolvaptanThe risk or severity of adverse effects can be increased when Carfentanil is combined with Tolvaptan.Approved
TopiramateThe risk or severity of adverse effects can be increased when Carfentanil is combined with Topiramate.Approved
TorasemideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Torasemide.Approved
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Carfentanil.Approved, Investigational
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Trans-2-Phenylcyclopropylamine.Experimental
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Carfentanil.Approved
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with Carfentanil.Approved, Investigational
TriamtereneThe risk or severity of adverse effects can be increased when Carfentanil is combined with Triamterene.Approved
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Carfentanil.Approved
TrichlormethiazideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Trichlormethiazide.Approved, Vet Approved
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Carfentanil.Approved
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Carfentanil.Approved, Vet Approved
TrihexyphenidylThe risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Carfentanil.Approved
TrimethaphanThe risk or severity of adverse effects can be increased when Trimethaphan is combined with Carfentanil.Approved
TrimipramineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Trimipramine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Triprolidine.Approved
TropicamideThe risk or severity of adverse effects can be increased when Tropicamide is combined with Carfentanil.Approved
TrospiumThe risk or severity of adverse effects can be increased when Trospium is combined with Carfentanil.Approved
TubocurarineThe risk or severity of adverse effects can be increased when Tubocurarine is combined with Carfentanil.Approved
Uc1010The risk or severity of adverse effects can be increased when Carfentanil is combined with Uc1010.Investigational
UlaritideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ularitide.Investigational
UmeclidiniumThe risk or severity of adverse effects can be increased when Umeclidinium is combined with Carfentanil.Approved
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Carfentanil.Approved, Investigational
VecuroniumThe risk or severity of adverse effects can be increased when Vecuronium is combined with Carfentanil.Approved
VenlafaxineCarfentanil may increase the serotonergic activities of Venlafaxine.Approved
VigabatrinThe risk or severity of adverse effects can be increased when Carfentanil is combined with Vigabatrin.Approved
VortioxetineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Vortioxetine.Approved
XylazineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Xylazine.Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Carfentanil.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Ziconotide.Approved
ZimelidineCarfentanil may increase the serotonergic activities of Zimelidine.Withdrawn
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Carfentanil.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Carfentanil is combined with Zolazepam.Vet Approved
ZolpidemCarfentanil may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Carfentanil is combined with Zonisamide.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Carfentanil.Approved
ZotepineThe risk or severity of adverse effects can be increased when Carfentanil is combined with Zotepine.Approved
ZuclopenthixolThe risk or severity of adverse effects can be increased when Carfentanil is combined with Zuclopenthixol.Approved, Investigational
Food InteractionsNot Available
References
Synthesis Reference

Louis P. Reiff, Paul B. Sollman, “Process of making carfentanil and related analgesics.” U.S. Patent US5106983, issued January, 1981.

US5106983
General References
  1. Wax PM, Becker CE, Curry SC: Unexpected "gas" casualties in Moscow: a medical toxicology perspective. Ann Emerg Med. 2003 May;41(5):700-5. [PubMed:12712038 ]
External Links
ATC CodesNot Available
AHFS CodesNot Available
PDB EntriesNot Available
FDA labelNot Available
MSDSNot Available
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.8605
Blood Brain Barrier+0.9762
Caco-2 permeable-0.5069
P-glycoprotein substrateSubstrate0.7011
P-glycoprotein inhibitor IInhibitor0.8424
P-glycoprotein inhibitor IINon-inhibitor0.6298
Renal organic cation transporterNon-inhibitor0.6504
CYP450 2C9 substrateNon-substrate0.8368
CYP450 2D6 substrateNon-substrate0.8791
CYP450 3A4 substrateSubstrate0.6667
CYP450 1A2 substrateNon-inhibitor0.9279
CYP450 2C9 inhibitorNon-inhibitor0.7664
CYP450 2D6 inhibitorNon-inhibitor0.8561
CYP450 2C19 inhibitorNon-inhibitor0.7325
CYP450 3A4 inhibitorNon-inhibitor0.6284
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.6023
Ames testNon AMES toxic0.7779
CarcinogenicityNon-carcinogens0.869
BiodegradationNot ready biodegradable0.9474
Rat acute toxicity2.9219 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9613
hERG inhibition (predictor II)Inhibitor0.6716
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental PropertiesNot Available
Predicted Properties
PropertyValueSource
Water Solubility0.0259 mg/mLALOGPS
logP3.7ALOGPS
logP3.67ChemAxon
logS-4.2ALOGPS
pKa (Strongest Basic)8.05ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area49.85 Å2ChemAxon
Rotatable Bond Count8ChemAxon
Refractivity114.38 m3·mol-1ChemAxon
Polarizability44.6 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as fentanyls. These are compounds containing the fentanyl moiety or a derivative, which is based on a N-(1-(2-phenylethyl)-4-piperidinyl)-N-phenylpropanamide skeleton.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassPiperidines
Sub ClassFentanyls
Direct ParentFentanyls
Alternative Parents
Substituents
  • Fentanyl
  • Alpha-amino acid or derivatives
  • Anilide
  • Piperidinecarboxylic acid
  • Phenethylamine
  • Aralkylamine
  • 4-aminopiperidine
  • Benzenoid
  • Monocyclic benzene moiety
  • Methyl ester
  • Tertiary carboxylic acid amide
  • Tertiary aliphatic amine
  • Tertiary amine
  • Carboxylic acid ester
  • Carboxamide group
  • Azacycle
  • Monocarboxylic acid or derivatives
  • Carboxylic acid derivative
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Amine
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Voltage-gated calcium channel activity
Specific Function:
Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociati...
Gene Name:
OPRM1
Uniprot ID:
P35372
Molecular Weight:
44778.855 Da
References
  1. Bencherif B, Wand GS, McCaul ME, Kim YK, Ilgin N, Dannals RF, Frost JJ: Mu-opioid receptor binding measured by [11C]carfentanil positron emission tomography is related to craving and mood in alcohol dependence. Biol Psychiatry. 2004 Feb 1;55(3):255-62. [PubMed:14744466 ]
  2. Bencherif B, Stumpf MJ, Links JM, Frost JJ: Application of MRI-based partial-volume correction to the analysis of PET images of mu-opioid receptors using statistical parametric mapping. J Nucl Med. 2004 Mar;45(3):402-8. [PubMed:15001679 ]
  3. Jewett DM, Kilbourn MR: In vivo evaluation of new carfentanil-based radioligands for the mu opiate receptor. Nucl Med Biol. 2004 Apr;31(3):321-5. [PubMed:15028244 ]
  4. Mayberg HS, Sadzot B, Meltzer CC, Fisher RS, Lesser RP, Dannals RF, Lever JR, Wilson AA, Ravert HT, Wagner HN Jr, et al.: Quantification of mu and non-mu opiate receptors in temporal lobe epilepsy using positron emission tomography. Ann Neurol. 1991 Jul;30(1):3-11. [PubMed:1656846 ]
  5. Bartenstein PA, Prevett MC, Duncan JS, Hajek M, Wieser HG: Quantification of opiate receptors in two patients with mesiobasal temporal lobe epilepsy, before and after selective amygdalohippocampectomy, using positron emission tomography. Epilepsy Res. 1994 Jun;18(2):119-25. [PubMed:7957034 ]
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
agonist
General Function:
Opioid receptor activity
Specific Function:
G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurot...
Gene Name:
OPRD1
Uniprot ID:
P41143
Molecular Weight:
40368.235 Da
References
  1. Mayberg HS, Sadzot B, Meltzer CC, Fisher RS, Lesser RP, Dannals RF, Lever JR, Wilson AA, Ravert HT, Wagner HN Jr, et al.: Quantification of mu and non-mu opiate receptors in temporal lobe epilepsy using positron emission tomography. Ann Neurol. 1991 Jul;30(1):3-11. [PubMed:1656846 ]
  2. Barry U, Zuo Z: Opioids: old drugs for potential new applications. Curr Pharm Des. 2005;11(10):1343-50. [PubMed:15853689 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
agonist
General Function:
Opioid receptor activity
Specific Function:
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates th...
Gene Name:
OPRK1
Uniprot ID:
P41145
Molecular Weight:
42644.665 Da
References
  1. Mayberg HS, Sadzot B, Meltzer CC, Fisher RS, Lesser RP, Dannals RF, Lever JR, Wilson AA, Ravert HT, Wagner HN Jr, et al.: Quantification of mu and non-mu opiate receptors in temporal lobe epilepsy using positron emission tomography. Ann Neurol. 1991 Jul;30(1):3-11. [PubMed:1656846 ]
  2. Barry U, Zuo Z: Opioids: old drugs for potential new applications. Curr Pharm Des. 2005;11(10):1343-50. [PubMed:15853689 ]
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Drug created on July 31, 2007 07:10 / Updated on August 17, 2016 12:23