Identification

Name
Rutin
Accession Number
DB01698  (EXPT02824)
Type
Small Molecule
Groups
Experimental, Investigational
Description

A flavonol glycoside found in many plants, including buckwheat; tobacco; forsythia; hydrangea; viola, etc. It has been used therapeutically to decrease capillary fragility. [PubChem]

Structure
Thumb
Synonyms
  • 2-(3,4-Dihydroxyphenyl)-5,7-Dihydroxy-4-Oxo-4h-Chromen-3-Yl 6-O-(6-Deoxy-Alpha-L-Mannopyranosyl)-Beta-D-Glucopyranoside
  • Phytomelin
  • quercetin-3-rutinoside
  • rutoside
  • sophorin
External IDs
C.I. 75730 / NSC-9220
Categories
UNII
5G06TVY3R7
CAS number
153-18-4
Weight
Average: 610.5175
Monoisotopic: 610.153384912
Chemical Formula
C27H30O16
InChI Key
IKGXIBQEEMLURG-NVPNHPEKSA-N
InChI
InChI=1S/C27H30O16/c1-8-17(32)20(35)22(37)26(40-8)39-7-15-18(33)21(36)23(38)27(42-15)43-25-19(34)16-13(31)5-10(28)6-14(16)41-24(25)9-2-3-11(29)12(30)4-9/h2-6,8,15,17-18,20-23,26-33,35-38H,7H2,1H3/t8-,15+,17-,18+,20+,21-,22+,23+,26+,27-/m0/s1
IUPAC Name
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}methyl)oxan-2-yl]oxy}-4H-chromen-4-one
SMILES

Pharmacology

Indication
Not Available
Structured Indications
Not Available
Pharmacodynamics
Not Available
Mechanism of action
TargetActionsOrganism
UAldo-keto reductase family 1 member C3Not AvailableHuman
UCarbonyl reductase [NADPH] 1Not AvailableHuman
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
AmodiaquineThe serum concentration of Amodiaquine can be increased when it is combined with Rutin.Approved, Investigational
AtorvastatinThe risk or severity of adverse effects can be increased when Rutin is combined with Atorvastatin.Approved
BromocriptineThe risk or severity of adverse effects can be increased when Bromocriptine is combined with Rutin.Approved, Investigational
CabergolineThe risk or severity of adverse effects can be increased when Cabergoline is combined with Rutin.Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Rutin.Withdrawn
DihydroergocornineThe risk or severity of adverse effects can be increased when Dihydroergocornine is combined with Rutin.Approved
DihydroergocristineThe risk or severity of adverse effects can be increased when Dihydroergocristine is combined with Rutin.Experimental
DihydroergocryptineThe risk or severity of adverse effects can be increased when Dihydroergocryptine is combined with Rutin.Experimental
DihydroergotamineThe risk or severity of adverse effects can be increased when Dihydroergotamine is combined with Rutin.Approved
ErgonovineThe risk or severity of adverse effects can be increased when Ergonovine is combined with Rutin.Approved
ErgotamineThe risk or severity of adverse effects can be increased when Ergotamine is combined with Rutin.Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Rutin.Approved
FluvastatinThe serum concentration of Fluvastatin can be increased when it is combined with Rutin.Approved
LisurideThe risk or severity of adverse effects can be increased when Lisuride is combined with Rutin.Approved, Investigational
LovastatinThe serum concentration of Lovastatin can be increased when it is combined with Rutin.Approved, Investigational
Lysergic Acid DiethylamideThe risk or severity of adverse effects can be increased when Lysergic Acid Diethylamide is combined with Rutin.Illicit, Investigational, Withdrawn
MetergolineThe risk or severity of adverse effects can be increased when Metergoline is combined with Rutin.Experimental
MethylergometrineThe risk or severity of adverse effects can be increased when Methylergometrine is combined with Rutin.Approved
MethysergideThe risk or severity of adverse effects can be increased when Methysergide is combined with Rutin.Approved
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Rutin.Approved, Investigational
MevastatinThe serum concentration of Mevastatin can be increased when it is combined with Rutin.Experimental
NicergolineThe risk or severity of adverse effects can be increased when Nicergoline is combined with Rutin.Approved, Investigational
PergolideThe risk or severity of adverse effects can be increased when Pergolide is combined with Rutin.Approved, Investigational, Vet Approved, Withdrawn
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Rutin.Approved
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Rutin.Approved
RosuvastatinThe serum concentration of Rosuvastatin can be increased when it is combined with Rutin.Approved
SimvastatinThe serum concentration of Simvastatin can be increased when it is combined with Rutin.Approved
TergurideThe risk or severity of adverse effects can be increased when Terguride is combined with Rutin.Experimental
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Rutin.Approved, Withdrawn
UbidecarenoneThe serum concentration of Ubidecarenone can be increased when it is combined with Rutin.Approved, Experimental
Food Interactions
Not Available

References

Synthesis Reference

Yukio Suzuki, Kei Suzuki, Masaru Yoneyama, Toshio Miyake, "4.sup.G -alpha-D-glucopyranosyl rutin, and its preparation and uses." U.S. Patent US5171573, issued October, 1979.

US5171573
General References
Not Available
External Links
Human Metabolome Database
HMDB03249
KEGG Compound
C05625
PubChem Compound
5280805
PubChem Substance
46508549
ChemSpider
4444362
ChEBI
28527
ChEMBL
CHEMBL226335
PharmGKB
PA451291
HET
RUT
Wikipedia
Rutin
ATC Codes
C05CA01 — RutosideC05CA51 — Rutoside, combinations
PDB Entries
1ry8
MSDS
Download (72 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
Not AvailableCompletedNot AvailableGlaucoma1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
  • V Sab Medical Labs Inc.
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)125 °CPhysProp
water solubility125 mg/LMERCK (1989)
Predicted Properties
PropertyValueSource
Water Solubility3.54 mg/mLALOGPS
logP0.15ALOGPS
logP-0.87ChemAxon
logS-2.2ALOGPS
pKa (Strongest Acidic)6.43ChemAxon
pKa (Strongest Basic)-3.7ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count16ChemAxon
Hydrogen Donor Count10ChemAxon
Polar Surface Area265.52 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity140.15 m3·mol-1ChemAxon
Polarizability57.08 Å3ChemAxon
Number of Rings5ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.8041
Blood Brain Barrier-0.8542
Caco-2 permeable-0.9172
P-glycoprotein substrateSubstrate0.6901
P-glycoprotein inhibitor INon-inhibitor0.8759
P-glycoprotein inhibitor IINon-inhibitor0.8546
Renal organic cation transporterNon-inhibitor0.8977
CYP450 2C9 substrateNon-substrate0.7639
CYP450 2D6 substrateNon-substrate0.8962
CYP450 3A4 substrateNon-substrate0.5374
CYP450 1A2 substrateNon-inhibitor0.8673
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.9545
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.9249
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.6787
Ames testNon AMES toxic0.5118
CarcinogenicityNon-carcinogens0.9608
BiodegradationNot ready biodegradable0.8339
Rat acute toxicity2.4984 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9814
hERG inhibition (predictor II)Non-inhibitor0.7469
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
MS/MS Spectrum - Quattro_QQQ 10V, PositiveLC-MS/MSsplash10-03di-0000009000-a6b8403579a83c69506b
MS/MS Spectrum - Quattro_QQQ 25V, PositiveLC-MS/MSsplash10-03di-0002009000-ffacf122369038644c02
MS/MS Spectrum - Quattro_QQQ 40V, PositiveLC-MS/MSsplash10-0w29-5009015000-f74826ba5205775d12b8
LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) 5V, PositiveLC-MS/MSsplash10-03di-0003109000-85542c3510756d258e11
LC-MS/MS Spectrum - LC-ESI-ITTOF (LCMS-IT-TOF) , PositiveLC-MS/MSsplash10-0ik9-0008109000-f0d08078ad4b887cce0d
LC-MS/MS Spectrum - LC-ESI-ITTOF (LCMS-IT-TOF) , NegativeLC-MS/MSsplash10-0a4i-0000009000-f07697affe03ff93dad3
LC-MS/MS Spectrum - LC-ESI-ITTOF (LCMS-IT-TOF) , PositiveLC-MS/MSsplash10-0udi-0009000000-1b117e308c1ab00aa4a7
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
MS/MS Spectrum - ESI-TOF , NegativeLC-MS/MSNot Available
MS/MS Spectrum - ESI-TOF 10V, NegativeLC-MS/MSNot Available
MS/MS Spectrum - ESI-TOF 40V, NegativeLC-MS/MSNot Available
MS/MS Spectrum - ESI-TOF , NegativeLC-MS/MSNot Available
MS/MS Spectrum - ESI-TOF 10V, NegativeLC-MS/MSNot Available
MS/MS Spectrum - ESI-TOF 40V, NegativeLC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-QTOF , negativeLC-MS/MSsplash10-0a4i-0000009000-dd163a2a17fe559c3482
LC-MS/MS Spectrum - LC-ESI-QTOF , negativeLC-MS/MSsplash10-0a4i-0000009000-7b408d31853f85c12619
LC-MS/MS Spectrum - LC-ESI-QTOF , negativeLC-MS/MSsplash10-0a4i-0001009000-3a559cbd175dfd7bafc9
LC-MS/MS Spectrum - LC-ESI-QTOF , negativeLC-MS/MSsplash10-0udi-0009005000-a090fd87b44b66b9f0c0
LC-MS/MS Spectrum - LC-ESI-QTOF , negativeLC-MS/MSsplash10-0udi-0009000000-8454cc7afaccaa2be7ac
MS/MS Spectrum - Linear Ion Trap , negativeLC-MS/MSsplash10-0udi-0009000000-188aab377f9eecd8695d
MS/MS Spectrum - Linear Ion Trap , negativeLC-MS/MSsplash10-0udi-0009000000-8027e3471abd62fb2791
MS/MS Spectrum - Linear Ion Trap , negativeLC-MS/MSsplash10-0udi-0009000000-5ec73bcca3286a80f7c6
MS/MS Spectrum - Linear Ion Trap , negativeLC-MS/MSsplash10-0udi-0009000000-ea0de1e1b0699fa8401d
MS/MS Spectrum - Linear Ion Trap , negativeLC-MS/MSsplash10-0udi-0009000000-a8dce85d4d31db22026b
MS/MS Spectrum - Linear Ion Trap , negativeLC-MS/MSsplash10-0udi-0009000000-2376e0472b15420aba8f
MS/MS Spectrum - Linear Ion Trap , negativeLC-MS/MSsplash10-0a4i-0000009002-ae4978beb8ec8448d966
MS/MS Spectrum - Linear Ion Trap , negativeLC-MS/MSsplash10-0a4i-0000009002-c7f26693cd399d8d8302
LC-MS/MS Spectrum - LC-ESI-TOF , negativeLC-MS/MSsplash10-0udi-0049001000-8327d9d15b0d22a0c968
MS/MS Spectrum - , negativeLC-MS/MSsplash10-0zfr-0118009000-bbfe9a963d6e073b31aa
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-03di-0004409000-c9657d18e3d38620d7c0
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0udi-0009300000-ff0584aa53087380857c
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0udi-0009000000-d8e250bcd87201ff91d8
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0udi-0009000000-cb501d427defe87144e1
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0udi-0009000000-382e4e2175615ff65850
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0wmi-0009506000-98ca7f7c8f3072af4481
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0wmi-0009506000-717207d912e0da3f0ec1
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0udi-0009000000-c8c1fc25375ea6875243
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0udi-0019000000-92c9eb453c2b2bb6047f
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0udi-0009300000-d5183f81716bf8deb8ee
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0udi-0009000000-a790b0597ebf4b0f07f0
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0udi-0009000000-707a876bedc341afce24
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0udi-0029300000-a6374dbb49e6d5bf31ae
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0uxr-0029400000-47da08e5dc97e23c44bf
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0udi-0549220000-79a7fad4164d8e1f5d57
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-03di-0179020000-363093d6c7189d2ca5b7
LC-MS/MS Spectrum - LC-ESI-ITTOF , positiveLC-MS/MSsplash10-0udi-0009000000-1b117e308c1ab00aa4a7
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-0udi-0009100000-580b79451bd64dfcab03
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-0udi-0009100000-8bbfe0044ae8800be3c8
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-001i-0009300000-caaa9f9ce4563b800c19
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-001i-0009300000-e598235294a3f55f962b
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-0udi-0009200000-f9d3912b5e9bcc4aa4a6
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-0udi-0009200000-031817287b54fa353ecd
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-001i-0009200000-2bf263364eccf1425f98
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-001i-0009200000-6c976c714e8f9a7558af
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-001i-0001319000-2f06049e21fa11589fb7
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-001i-0001319000-4c4d3b0053f951060192
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-0udi-0009200000-e1502b5888ff7ad6d318
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-0udi-0009100000-6d0bd005bd7b223c7cf5
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-001i-0009100000-3b95244720444d2f3d13
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-001i-0009200000-25001dbcf8355eaf8bd0
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-0006-0016951000-1a24ae1c026ee49c0b0b
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-0006-0017961000-90d27c883fd31667a17c
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-001r-1010105009-fe5059a016b66f6e6508
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-001i-1010105009-aca266334d999e83075f
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-0ika-0080109107-1d617056ba5c260c56b0
MS/MS Spectrum - Linear Ion Trap , positiveLC-MS/MSsplash10-0udm-0230119117-ddbbc348bb71199c4af9
MS/MS Spectrum - , positiveLC-MS/MSsplash10-0udi-0009100000-c5715285ddf62f77c126
MS/MS Spectrum - , positiveLC-MS/MSsplash10-0udi-0009000000-4a64a91365b6888199d3
MS/MS Spectrum - , positiveLC-MS/MSsplash10-001i-0001009000-be5fbd1a3dc6eb89cea6
1H NMR Spectrum1D NMRNot Applicable
13C NMR Spectrum1D NMRNot Applicable
[1H,13C] 2D NMR Spectrum2D NMRNot Applicable

Taxonomy

Description
This compound belongs to the class of organic compounds known as flavonoid-3-o-glycosides. These are phenolic compounds containing a flavonoid moiety which is O-glycosidically linked to carbohydrate moiety at the C3-position.
Kingdom
Organic compounds
Super Class
Phenylpropanoids and polyketides
Class
Flavonoids
Sub Class
Flavonoid glycosides
Direct Parent
Flavonoid-3-O-glycosides
Alternative Parents
3'-hydroxyflavonoids / 4'-hydroxyflavonoids / 5-hydroxyflavonoids / 7-hydroxyflavonoids / Flavones / O-glycosyl compounds / Chromones / Disaccharides / Catechols / Pyranones and derivatives
show 12 more
Substituents
Flavonoid-3-o-glycoside / Hydroxyflavonoid / Flavone / 3'-hydroxyflavonoid / 4'-hydroxyflavonoid / 5-hydroxyflavonoid / 7-hydroxyflavonoid / O-glycosyl compound / Glycosyl compound / Disaccharide
show 25 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
rutinoside, disaccharide derivative, tetrahydroxyflavone, quercetin O-glucoside (CHEBI:28527) / flavonols (C05625)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
Specific Function
Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2....
Gene Name
AKR1C3
Uniprot ID
P42330
Uniprot Name
Aldo-keto reductase family 1 member C3
Molecular Weight
36852.89 Da
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Prostaglandin-e2 9-reductase activity
Specific Function
NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. ...
Gene Name
CBR1
Uniprot ID
P16152
Uniprot Name
Carbonyl reductase [NADPH] 1
Molecular Weight
30374.73 Da
References
  1. Carlquist M, Frejd T, Gorwa-Grauslund MF: Flavonoids as inhibitors of human carbonyl reductase 1. Chem Biol Interact. 2008 Jul 30;174(2):98-108. doi: 10.1016/j.cbi.2008.05.021. Epub 2008 May 23. [PubMed:18579125]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C8
Uniprot ID
P10632
Uniprot Name
Cytochrome P450 2C8
Molecular Weight
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally un...
Gene Name
CYP2C9
Uniprot ID
P11712
Uniprot Name
Cytochrome P450 2C9
Molecular Weight
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic...
Gene Name
CYP2D6
Uniprot ID
P10635
Uniprot Name
Cytochrome P450 2D6
Molecular Weight
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
Details
4. Cytochrome P450 3A4
Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Inhibitor
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]

Drug created on June 13, 2005 07:24 / Updated on November 09, 2017 03:03