Calcium ascorbate

Identification

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Name
Calcium ascorbate
Accession Number
DB14483  (DBSALT002425)
Type
Small Molecule
Groups
Approved, Nutraceutical
Description
Not Available
Structure
Thumb
Synonyms
  • Ascorbic acid calcium salt
  • Calcium ascorbate
  • Calcium ascorbate anhydrous
  • Calcium diascorbate
  • L-ascorbic acid, calcium salt (2:1)
Product Ingredients
IngredientUNIICASInChI Key
Calcium ascorbate dihydrate183E4W213W5743-28-2RGJHWLDSRIHFKY-FWCDDDAWSA-L
Active Moieties
NameKindUNIICASInChI Key
Ascorbic acidsaltPQ6CK8PD0R50-81-7CIWBSHSKHKDKBQ-JLAZNSOCSA-N
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Ascorbate C-500Capsule500 mgOralSeroyal International Inc.1998-12-31Not applicableCanada
Buffered Vitamin C 1000mgTablet1000 mgOralGeneral Nutrition Canada Inc.1997-11-262005-08-05Canada
Calcium Ascorbate 1000mgCapsule1000 mgOralNatural Factors Nutritional Products Ltd.1996-12-312007-08-07Canada
Calcium Ascorbate Crystals 1250mg/0.25tspPowder1.25 gOralSwiss Herbal Remedies Ltd.1987-12-312009-08-04Canada
Calcium Ascorbate Crystals Vitamin C 1gm/mlPowder1 gOralVita Health Products Inc1991-12-312004-07-26Canada
Calcium Ascorbate FccPowder4.5 gOralAlbi Naturals1981-12-312009-07-15Canada
Calcium Ascorbate PwrPowder825 mgOralJamieson Laboratories Ltd1979-12-312000-09-08Canada
Calcium Ascorbate Pwr 1.3gm/1.25mlPowder1.3 gOralGahler Enterprises Ltd.1982-12-312007-08-07Canada
Calcium Ascorbate Tab 500mgTablet500 mgOralAlbi Imports Ltd.1986-12-312001-07-27Canada
Chewable Vitamin C Tab 250mgTablet250 mgOralSutra Health Systems Canada1986-12-311996-12-12Canada
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
A/o-26 - CapletCalcium ascorbate (250 mg) + Beta carotene (7500 unit) + Calcium (75 mg) + Copper (1 mg) + DL-alpha tocopheryl acetate (100 unit) + Folic acid (.4 mg) + Manganese (2.5 mg) + Racemethionine (50 mg) + Selenium (100 mcg) + Zinc (7.5 mg)TabletOralEnviro Tech International Canada1996-12-191999-07-26Canada
Aces TabCalcium ascorbate (350 mg) + Cholecalciferol (200 unit) + Chromium (25 mcg) + Selenium (100 mcg) + Vitamin A (5000 unit) + Vitamin E (200 unit) + Zinc (25 mg)TabletOralNu Life Nutrition Ltd.1987-12-312005-03-15Canada
Acti-megascorb Crystals PwrCalcium ascorbate (2 g) + Calcium (260 mg)PowderOralActi Form Ltd.1991-12-312005-03-21Canada
Acti-MN + B1 + C CapletCalcium ascorbate (100 mg) + Manganese (30.0 mg) + Thiamine hydrochloride (20 mg)TabletOralActi Form Ltd.1991-12-312005-03-21Canada
Am CapsCalcium ascorbate (30 mg) + Beta carotene (2500 unit) + Biotin (150 mcg) + Cholecalciferol (200 unit) + Cyanocobalamin (5 mcg) + Folic acid (0.20 mg) + Nicotinamide (10 mg) + Pyridoxine hydrochloride (1 mg) + Riboflavin (0.85 mg) + Selenium (50 mcg) + Thiamine (0.75 mg) + Vitamin E (15 unit)CapsuleOralNew Vision Nutritionals CompanyNot applicableNot applicableCanada
Astral C TabCalcium ascorbate (500 mg) + Calcium (65 mg)TabletOralAlbi Naturals1994-12-312008-07-17Canada
Body RoxCalcium ascorbate (167.0 mg) + Beta carotene (3000.0 unit) + Biotin (100.0 mcg) + Calcium (75.0 mg) + Cholecalciferol (133.0 unit) + Choline bitartrate (15.0 mg) + Chromium (50.0 mcg) + Copper (0.33 mg) + Cyanocobalamin (20.0 mcg) + Folic acid (0.267 mg) + Inositol (10.0 mg) + Magnesium (37.5 mg) + Manganese (1.0 mg) + Molybdenum (15.0 mcg) + Niacin (1.66 mg) + Nicotinamide (3.3 mg) + Calcium pantothenate (10.0 mg) + Potassium Iodide (0.05 mg) + Pyridoxine hydrochloride (3.0 mg) + Riboflavin (3.0 mg) + Selenium (40.0 mcg) + Silicon (1.0 mg) + Thiamine hydrochloride (3.0 mg) + Vanadium (10.0 mcg) + Zinc (4.0 mg) + alpha-Tocopherol succinate (66.7 unit)TabletOralUsana Health Sciences, Inc.2003-09-022008-06-27Canada
C-1000 Plus Zinc & PotassiumCalcium ascorbate (1 g) + Potassium (12 mg) + Potassium (13 mg) + Zinc (5 mg)TabletOralNu Life Nutrition Ltd.1987-12-312005-03-15Canada
C-crystals With CalciumCalcium ascorbate (2 g) + Calcium (230 mg)PowderOralAlive Vitamins1985-12-311997-08-11Canada
Calcium Ascorbate 1000 Mg - TabletCalcium ascorbate (900 mg) + Calcium (100 mg)TabletOralHealth Wise Nutrition Inc.1997-08-152000-07-29Canada
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Cavan OneCalcium ascorbate dihydrate (25 mg/1) + Alpha-Linolenic Acid (30 mg/1) + Calcium (150 mg/1) + Cholecalciferol (170 [iU]/1) + DL-alpha tocopheryl acetate (30 [iU]/1) + Doconexent (260 mg/1) + Ferrous asparto glycinate (7 mg/1) + Folic acid (1 mg/1) + Icosapent (40 mg/1) + Iron (20 mg/1) + Linoleic acid (30 mg/1) + Pyridoxine hydrochloride (25 mg/1)Capsule, gelatin coatedOralSeton Pharmaceuticals2009-10-302011-11-27Us
Ferrex 150 Forte PlusCalcium ascorbate dihydrate (60 mg/1) + Calcium threonate (0.8 mg/1) + Cyanocobalamin (25 ug/1) + Folic acid (1 mg/1) + Iron (150 mg/1) + Succinic acid (50 mg/1)CapsuleOralBreckenridge Pharmaceutical, Inc.2008-08-012012-09-30Us
Folcaps Care OneCalcium ascorbate dihydrate (24 mg/1) + Alpha-Linolenic Acid (50 mg/1) + Biotin (300 mg/1) + Calcium Carbonate (100 mg/1) + Calcium threonate (1 mg/1) + Cholecalciferol (800 [iU]/1) + Doconexent (350 mg/1) + Docusate sodium (50 mg/1) + Folic acid (1 mg/1) + Icosapent (100 mg/1) + Iodine (150 ug/1) + Iron (27 mg/1) + Magnesium (50 mg/1) + Nicotinamide (10 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (1.5 mg/1) + Zinc (5 mg/1) + alpha-Tocopherol acetate (15 [iU]/1)Capsule, gelatin coatedOralMayne Pharma2009-05-012016-12-31Us
Folcaps Omega-3Calcium ascorbate dihydrate (24 mg/1) + Alpha-Linolenic Acid (30 mg/1) + Calcium (150 mg/1) + Calcium threonate (1 mg/1) + Cholecalciferol (170 [iU]/1) + Doconexent (260 mg/1) + Ferrous asparto glycinate (7 mg/1) + Folic acid (1 mg/1) + Icosapent (40 mg/1) + Iron (20 mg/1) + Pyridoxine hydrochloride (25 mg/1) + alpha-Tocopherol acetate (30 [iU]/1)Capsule, gelatin coatedOralMayne Pharma2011-01-032016-12-31Us
Nestabs ONECalcium ascorbate dihydrate (18 mg/1) + Antazoline (225 mg/1) + Cholecalciferol (6.25 ug/1) + Cyanocobalamin (15 ug/1) + Folic acid (1 mg/1) + Iron (38 mg/1) + Magnesium oxide (15 mg/1) + Pyridoxine hydrochloride (30 mg/1) + Tocopherol (10 mg/1) + Zinc oxide (1 mg/1)Capsule, gelatin coatedOralWomens Choice Pharmaceuticals, Llc2017-07-20Not applicableUs
PrimaCareCalcium ascorbate dihydrate (25 mg/1) + Biotin (1 mg/1) + Calcium Carbonate (100 mg/1) + Cholecalciferol (1000 [iU]/1) + Folic acid (1 mg/1) + Linoleic acid (50 mg/1) + Magnesium oxide (50 mg/1) + Nicotinamide (10 mg/1) + Omega-3 fatty acids (420 mg/1) + Potassium Iodide (150 ug/1) + Pyridoxine (50 mg/1) + Riboflavin (1.5 mg/1) + Zinc (15 mg/1) + alpha-Tocopherol acetate (15 [iU]/1)PillOralAvion Pharmaceuticals, Llc2017-01-23Not applicableUs
Se-Care ChewableCalcium ascorbate dihydrate (50 mg/1) + Calcium Carbonate (250 mg/1) + Calcium threonate (50 mg/1) + Cholecalciferol (6 ug/1) + Cupric oxide (2 mg/1) + DL-alpha tocopheryl acetate (3.5 [iU]/1) + Ferrous fumarate (40 mg/1) + Folic acid (1 mg/1) + Magnesium oxide (50 mg/1) + Pyridoxine hydrochloride (2 mg/1) + Zinc oxide (15 mg/1)Tablet, chewableOralSeton Pharmaceuticals2009-05-012011-08-31Us
Se-Care ConceiveCalcium ascorbate dihydrate (30 mg/1) + Calcium Carbonate (200 mg/1) + Calcium threonate (30 mg/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (12 ug/1) + DL-alpha tocopheryl acetate (30 [iU]/1) + Ferrous fumarate (30 mg/1) + Folic acid (1 mg/1) + Magnesium oxide (100 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (3.4 mg/1) + Thiamine mononitrate (3 mg/1) + Zinc oxide (15 mg/1)Tablet, film coatedOralSeton Pharmaceuticals2009-05-052011-04-15Us
Se-Natal 19 ChewableCalcium ascorbate dihydrate (100 mg/1) + Beta carotene (1000 [iU]/1) + Calcium Carbonate (200 mg/1) + Cholecalciferol (400 [iU]/1) + Cyanocobalamin (12 ug/1) + DL-alpha tocopheryl acetate (30 [iU]/1) + Ferrous fumarate (29 mg/1) + Folic acid (1 mg/1) + Nicotinamide (15 mg/1) + Calcium pantothenate (7 mg/1) + Pyridoxine hydrochloride (20 mg/1) + Riboflavin (3 mg/1) + Thiamine mononitrate (3 mg/1) + Zinc oxide (20 mg/1)Tablet, chewableOralSeton Pharmaceuticals2009-07-01Not applicableUs
Se-Vate 21/7Calcium ascorbate dihydrate (60 mg/1) + Ascorbic acid (140 mg/1) + Calcium threonate (0.8 mg/1) + Cyanocobalamin (10 ug/1) + Ferrous asparto glycinate (70 mg/1) + Ferrous fumarate (81 mg/1) + Folic acid (1 mg/1) + Succinic acid (150 mg/1)KitSeton Pharmaceuticals2009-05-122011-05-30Us
Categories
UNII
J96U0ZD4Y6
CAS number
5743-27-1
Weight
Average: 390.31
Monoisotopic: 390.0111168
Chemical Formula
C12H14CaO12
InChI Key
BLORRZQTHNGFTI-ZZMNMWMASA-L
InChI
InChI=1S/2C6H8O6.Ca/c2*7-1-2(8)5-3(9)4(10)6(11)12-5;/h2*2,5,7-10H,1H2;/q;;+2/p-2/t2*2-,5+;/m00./s1
IUPAC Name
calcium bis((2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate)
SMILES
[Ca++].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-]

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Additional Data Available
Adverse Effects

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

Structured data representing warnings from the black box section of drug labels. These warnings cover important and dangerous risks, contraindications, or adverse effects.

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Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
2,5-Dimethoxy-4-ethylamphetamineThe serum concentration of 2,5-Dimethoxy-4-ethylamphetamine can be decreased when it is combined with Calcium ascorbate.
2,5-Dimethoxy-4-ethylthioamphetamineThe serum concentration of 2,5-Dimethoxy-4-ethylthioamphetamine can be decreased when it is combined with Calcium ascorbate.
4-Bromo-2,5-dimethoxyamphetamineThe serum concentration of 4-Bromo-2,5-dimethoxyamphetamine can be decreased when it is combined with Calcium ascorbate.
AmphetamineThe serum concentration of Amphetamine can be decreased when it is combined with Calcium ascorbate.
BenzphetamineThe serum concentration of Benzphetamine can be decreased when it is combined with Calcium ascorbate.
Biochanin AThe serum concentration of Calcium ascorbate can be decreased when it is combined with Biochanin A.
BortezomibThe therapeutic efficacy of Bortezomib can be decreased when used in combination with Calcium ascorbate.
ChlorotrianiseneThe serum concentration of Calcium ascorbate can be decreased when it is combined with Chlorotrianisene.
ChlorphentermineThe serum concentration of Chlorphentermine can be decreased when it is combined with Calcium ascorbate.
ChlorpropamideCalcium ascorbate may decrease the excretion rate of Chlorpropamide which could result in a higher serum level.
Additional Data Available
  • Extended Description
    Extended Description

    Extended description of the mechanism of action and particular properties of each drug interaction.

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  • Severity
    Severity

    A severity rating for each drug interaction, from minor to major.

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  • Evidence Level
    Evidence Level

    A rating for the strength of the evidence supporting each drug interaction.

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  • Action
    Action

    An effect category for each drug interaction. Know how this interaction affects the subject drug.

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Food Interactions
Not Available

References

General References
Not Available
External Links
ChemSpider
22900989
ChEMBL
CHEMBL2146095
Wikipedia
Calcium_ascorbate
AHFS Codes
  • 88:04.00 — Vitamin A
  • 88:12.00 — Vitamin C

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
PowderOral
TabletOral166.7 mg
TabletOral1000 mg
CapsuleOral1000 mg
PowderOral1.25 g
PowderOral1 g
PowderOral4.5 g
PowderOral825 mg
PowderOral1.3 g
Capsule, gelatin coatedOral
TabletOral250 mg
Tablet, coatedOral
Tablet, extended releaseOral
CapsuleOral
TabletOral
Powder, for solutionOral
CapsuleOral500 mg
CapsuleOral660 mg
PowderOral1000 mg
Capsule, liquid filledOral
PillOral
Tablet, chewableOral
Tablet, film coatedOral
Kit
CapsuleOral200 mg
EmulsionTopical
LiquidOral
TabletOral1 g
TabletOral500 mg
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility16.0 mg/mLALOGPS
logP-1.6ALOGPS
logP-1.9ChemAxon
logS-1.4ALOGPS
pKa (Strongest Acidic)4.36ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area110.05 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity47.58 m3·mol-1ChemAxon
Polarizability14.48 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on July 06, 2018 16:11 / Updated on June 24, 2019 13:09