Glaucoma

Also known as: Glaucoma NOS / Glaucoma, unspecified / Unspecified glaucoma

DrugDrug NameDrug Description
DB00484BrimonidineBrimonidine is an alpha-adrenergic agonist and 2-imidazoline derivative that was first introduced in 1996.[A178951] It is considered to be a third generation alpha-2 aadrenergic receptor agonist, since it displays preferential binding at alpha-2 adrenoceptors over alpha-1 receptors.[A179002] Brimonidine displays a higher selectivity toward the alpha-2 adrenergic receptors than [clonidine] or [apraclonidine], which are also alpha-2 adrenergic agonists.[A178969] Alpha-2 adrenergic agonists are members of the ocular hypotensive agent drug class that are used in the chronic treatment of glaucoma. Early treatment and management of glaucoma, which predominantly involves the lowering of intraocular pressure, is critical since glaucoma is considered to be a common cause of blindness worldwide.[A178948,A178969] Ophthalmically, brimonidine is used to lower intraocular pressure by reducing aqueous humor production and increasing uveoscleral outflow. Because it is oxidately stable, brimonidine is associated with fewer reports of ocular allergic reactions compared to other alpha-2 adrenergic agonists.[A178969] The ophthalmic solution of brimonidine was first approved by the FDA in 1996 as Alphagan [label] and brimonidine is the only selective alpha-adrenergic receptor agonist approved for chronic treatment in glaucoma.[A36674] Brimonidine is also found in ophthalmic solutions in combination with [brinzolamide] under the market name Simbrinza for the reduction in intraocular pressure. Unlike nonselective beta-blockers used in ocular hypertension, brimonidine is not associated with significantly adverse cardiopulmonary side effects.[A178945] Thus brimonidine is an effective and safe alternative to beta-blockers, in patients with, or at high risk for, cardiopulmonary disease.[A178948] The topical form of brimonidine was approved by the FDA in August 2013 for the symptomatic treatment of persistent facial erythema of rosacea in adults. It is marketed under the brand name Mirvaso.[L6535] Brimonidine is the first topical treatment approved for facial erythema of rosacea.[A178978]
DrugDrug NamePhaseStatusCount
DB00316Acetaminophen0Completed1
DB00373Timolol0Completed1
DB05288Anecortave acetate1Completed1
DB12256Bamosiran1Completed1
DB00559Bosentan1Completed1
DB00484Brimonidine1Completed1
DB13926Cenegermin1Completed1
DB00869Dorzolamide1Completed1
DB00869Dorzolamide1Recruiting1
DB00654Latanoprost1Completed3
DB00338Omeprazole1Unknown Status1
DB08819Tafluprost1Completed1
DB00373Timolol1Completed2
DB00373Timolol1Recruiting1
DB00287Travoprost1Completed1
DB12256Bamosiran1 / 2Completed1
DB00905Bimatoprost1 / 2Completed1
DB01194Brinzolamide1 / 2Completed1
DB01164Calcium Chloride1 / 2Completed1
DB11121Chloroxylenol1 / 2Completed1
DB05757DNB-0011 / 2Completed1
DB00903Etacrynic acid1 / 2Completed1
DB00654Latanoprost1 / 2Completed1
DB09407Magnesium chloride1 / 2Completed1
DB00305Mitomycin1 / 2Completed1
DB00761Potassium chloride1 / 2Completed1
DB01270Ranibizumab1 / 2Completed1
DB01270Ranibizumab1 / 2Withdrawn1
DB12977Simenepag isopropyl1 / 2Completed1
DB09154Sodium Citrate1 / 2Completed1
DB09395Sodium acetate1 / 2Completed1
DB09153Sodium chloride1 / 2Completed1
DB13122Trabodenoson1 / 2Completed1
DB00905Bimatoprost2Completed3
DB00484Brimonidine2Completed1
DB00484Brimonidine2Unknown Status1
DB01194Brinzolamide2Completed1
DB00869Dorzolamide2Completed2
DB00125L-Arginine2Completed2
DB00654Latanoprost2Completed5
DB00654Latanoprost2Terminated1
DB00654Latanoprost2Unknown Status1
DB00305Mitomycin2Active Not Recruiting1
DB00305Mitomycin2Completed1
DB14852PRM-1512Completed1
DB05511Piclidenoson2Recruiting1
DB00373Timolol2Completed4
DB00373Timolol2Terminated1
DB00287Travoprost2Completed3
DB00112Bevacizumab2 / 3Completed3
DB01164Calcium Chloride2 / 3Completed1
DB09407Magnesium chloride2 / 3Completed1
DB00305Mitomycin2 / 3Completed3
DB12251Moxaverine2 / 3Completed1
DB00761Potassium chloride2 / 3Completed1
DB01270Ranibizumab2 / 3Completed1
DB09154Sodium Citrate2 / 3Completed1
DB09395Sodium acetate2 / 3Completed1
DB09153Sodium chloride2 / 3Completed1
DB00620Triamcinolone2 / 3Completed1
DB00819Acetazolamide3Recruiting1
DB08885Aflibercept3Completed1
DB00195Betaxolol3Completed2
DB00112Bevacizumab3Active Not Recruiting1
DB00905Bimatoprost3Completed3
DB00905Bimatoprost3Recruiting2
DB00484Brimonidine3Completed4
DB00484Brimonidine3Unknown Status1
DB01194Brinzolamide3Completed3
DB01194Brinzolamide3Recruiting1
DB01194Brinzolamide3Terminated2
DB01194Brinzolamide3Unknown Status2
DB01234Dexamethasone3Active Not Recruiting1
DB00869Dorzolamide3Completed4
DB00869Dorzolamide3Recruiting1
DB00869Dorzolamide3Terminated1
DB00324Fluorometholone3Completed1
DB00544Fluorouracil3Active Not Recruiting1
DB00544Fluorouracil3Completed1
DB00654Latanoprost3Completed7
DB00654Latanoprost3Recruiting1
DB00654Latanoprost3Unknown Status1
DB11660Latanoprostene Bunod3Completed1
DB09351Levobetaxolol3Completed1
DB00703Methazolamide3Recruiting1
DB00305Mitomycin3Completed1
DB00305Mitomycin3Unknown Status1
DB13931Netarsudil3Completed1
DB01165Ofloxacin3Not Yet Recruiting1
DB01085Pilocarpine3Not Yet Recruiting1
DB00860Prednisolone3Not Yet Recruiting1
DB01270Ranibizumab3Completed1
DB08819Tafluprost3Completed1
DB08819Tafluprost3Unknown Status1
DB00373Timolol3Completed13
DB00373Timolol3Recruiting1
DB00373Timolol3Terminated2
DB00373Timolol3Unknown Status2
DB00287Travoprost3Recruiting1
DB00287Travoprost3Terminated2
DB00287Travoprost3Unknown Status2
DB10575Turkey3Completed1
DB00819Acetazolamide4Recruiting1
DB00819Acetazolamide4Unknown Status1
DB00112Bevacizumab4Completed2
DB00112Bevacizumab4Unknown Status1
DB00905Bimatoprost4Completed14
DB00905Bimatoprost4Recruiting2
DB00905Bimatoprost4Withdrawn1
DB00484Brimonidine4Completed12
DB00484Brimonidine4Terminated1
DB01194Brinzolamide4Completed17
DB01194Brinzolamide4Recruiting1
DB01194Brinzolamide4Terminated1
DB00963Bromfenac4Not Yet Recruiting1
DB01164Calcium Chloride4Completed1
DB11121Chloroxylenol4Completed1
DB12153Citicoline4Completed1
DB01234Dexamethasone4Not Yet Recruiting1
DB00633Dexmedetomidine4Completed1
DB00586Diclofenac4Completed1
DB00869Dorzolamide4Completed9
DB00869Dorzolamide4Recruiting1
DB00869Dorzolamide4Unknown Status1
DB00544Fluorouracil4Completed1
DB09462Glycerin4Completed1
DB11075Hypromellose4Completed4
DB00465Ketorolac4Completed1
DB00654Latanoprost4Completed22
DB00654Latanoprost4Recruiting1
DB00654Latanoprost4Terminated1
DB00654Latanoprost4Unknown Status1
DB00654Latanoprost4Withdrawn1
DB09407Magnesium chloride4Completed1
DB00305Mitomycin4Completed2
DB00305Mitomycin4Recruiting1
DB00305Mitomycin4Unknown Status1
DB06690Nitrous oxide4Completed1
DB11077Polyethylene glycol 4004Completed1
DB11060Polyvinyl alcohol4Completed1
DB00761Potassium chloride4Completed1
DB00860Prednisolone4Completed2
DB01098Rosuvastatin4Withdrawn1
DB09154Sodium Citrate4Completed1
DB09395Sodium acetate4Completed1
DB09153Sodium chloride4Completed1
DB08819Tafluprost4Completed3
DB08819Tafluprost4Recruiting1
DB08819Tafluprost4Withdrawn1
DB00373Timolol4Completed25
DB00373Timolol4Recruiting1
DB00373Timolol4Terminated1
DB00373Timolol4Unknown Status1
DB00373Timolol4Withdrawn1
DB00287Travoprost4Completed17
DB00287Travoprost4Recruiting1
DB00287Travoprost4Terminated1
DB00620Triamcinolone4Not Yet Recruiting1
DB00964ApraclonidineNot AvailableUnknown Status1
DB00126Ascorbic acidNot AvailableCompleted1
DB00112BevacizumabNot AvailableCompleted1
DB00905BimatoprostNot AvailableTerminated1
DB12792BoscalidNot AvailableCompleted1
DB00484BrimonidineNot AvailableCompleted4
DB00484BrimonidineNot AvailableUnknown Status1
DB00484BrimonidineNot AvailableWithdrawn1
DB11136ChromiumNot AvailableCompleted1
DB00091CiclosporinNot AvailableCompleted1
DB02587ColforsinNot AvailableCompleted1
DB01234DexamethasoneNot AvailableUnknown Status1
DB00869DorzolamideNot AvailableCompleted1
DB00869DorzolamideNot AvailableUnknown Status1
DB00869DorzolamideNot AvailableWithdrawn1
DB09462GlycerinNot AvailableCompleted1
DB08818Hyaluronic acidNot AvailableUnknown Status1
DB11075HypromelloseNot AvailableCompleted1
DB11075HypromelloseNot AvailableUnknown Status1
DB01050IbuprofenNot AvailableCompleted1
DB00465KetorolacNot AvailableUnknown Status1
DB00654LatanoprostNot AvailableCompleted4
DB00654LatanoprostNot AvailableNot Yet Recruiting1
DB00654LatanoprostNot AvailableRecruiting1
DB00654LatanoprostNot AvailableUnknown Status1
DB06757ManganeseNot AvailableCompleted1
DB14009Medical CannabisNot AvailableRecruiting1
DB00968MethyldopaNot AvailableCompleted1
DB00305MitomycinNot AvailableRecruiting1
DB00727NitroglycerinNot AvailableCompleted1
DB01085PilocarpineNot AvailableRecruiting1
DB11077Polyethylene glycol 400Not AvailableCompleted1
DB11060Polyvinyl alcoholNot AvailableCompleted1
DB00860PrednisoloneNot AvailableCompleted1
DB01270RanibizumabNot AvailableCompleted1
DB01270RanibizumabNot AvailableTerminated1
DB01698RutinNot AvailableCompleted1
DB11135SeleniumNot AvailableCompleted1
DB00373TimololNot AvailableCompleted4
DB00373TimololNot AvailableUnknown Status1
DB00373TimololNot AvailableWithdrawn1
DB00287TravoprostNot AvailableCompleted1
DB00620TriamcinoloneNot AvailableUnknown Status1
DB01593ZincNot AvailableCompleted1