Sleep disorders and disturbances

Also known as: Sleeping Problems / Sleep Problem / Sleep Disorders / Sleep Problems / Insomnia / Sleep disorder / Disorder sleep / Sleep disorder (NOS) / Sleep disorder NOS

DrugDrug NameDrug Description
DB00321AmitriptylineA tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety.
DB00370MirtazapineA tetracyclic antidepressant used in the treatment of major depression and is used off-label as a drug for insomnia and to increase appetite.
DrugDrug NameTargetType
DB00321AmitriptylineSodium-dependent serotonin transportertarget
DB00321AmitriptylineSodium-dependent noradrenaline transportertarget
DB00321AmitriptylinePotassium voltage-gated channel subfamily KQT member 2target
DB00321AmitriptylineAlpha-2A adrenergic receptortarget
DB00321AmitriptylineCytochrome P450 1A2enzyme
DB00321AmitriptylineCytochrome P450 2C19enzyme
DB00321AmitriptylineCytochrome P450 2D6enzyme
DB00321AmitriptylineSerum albumincarrier
DB00321AmitriptylineAlpha-1-acid glycoprotein 1carrier
DB00321AmitriptylineHistamine H1 receptortarget
DB00321Amitriptyline5-hydroxytryptamine receptor 2Atarget
DB00321Amitriptyline5-hydroxytryptamine receptor 1Atarget
DB00321AmitriptylineAlpha-1A adrenergic receptortarget
DB00321AmitriptylineCytochrome P450 3A4enzyme
DB00321AmitriptylineCytochrome P450 3A5enzyme
DB00321AmitriptylinePotassium voltage-gated channel subfamily A member 1target
DB00321AmitriptylineAlpha-1D adrenergic receptortarget
DB00321AmitriptylineDelta-type opioid receptortarget
DB00321AmitriptylineKappa-type opioid receptortarget
DB00321AmitriptylineHigh affinity nerve growth factor receptortarget
DB00321AmitriptylineBDNF/NT-3 growth factors receptortarget
DB00321AmitriptylineCytochrome P450 2C9enzyme
DB00321AmitriptylineCytochrome P450 2B6enzyme
DB00321AmitriptylineCytochrome P450 2C8enzyme
DB00321AmitriptylineHistamine H2 receptortarget
DB00321AmitriptylineHistamine H4 receptortarget
DB00321AmitriptylineSigma non-opioid intracellular receptor 1target
DB00321Amitriptyline5-hydroxytryptamine receptor 2Ctarget
DB00321AmitriptylineAlpha-1B adrenergic receptortarget
DB00321Amitriptyline5-hydroxytryptamine receptor 7target
DB00321Amitriptyline5-hydroxytryptamine receptor 1Dtarget
DB00321AmitriptylineMu-type opioid receptortarget
DB00321Amitriptyline5-hydroxytryptamine receptor 1Btarget
DB00321Amitriptyline5-hydroxytryptamine receptor 6target
DB00321AmitriptylinePotassium voltage-gated channel subfamily KQT member 3target
DB00321AmitriptylineUDP-glucuronosyltransferase 2B10enzyme
DB00321Amitriptyline5-hydroxytryptamine receptor 1Ctarget
DB00321AmitriptylineMuscarinic acetylcholine receptortarget
DB00321AmitriptylineHERG human cardiac K+ channeltarget
DB00321AmitriptylineP-glycoprotein 1transporter
DB00321AmitriptylineUDP-glucuronosyltransferase 1-4enzyme
DB00370Mirtazapine5-hydroxytryptamine receptor 2Atarget
DB00370Mirtazapine5HT3 serotonin receptortarget
DB00370MirtazapineAlpha-2A adrenergic receptortarget
DB00370Mirtazapine5-hydroxytryptamine receptor 2Ctarget
DB00370MirtazapineKappa-type opioid receptortarget
DB00370MirtazapineHistamine H1 receptortarget
DB00370MirtazapineCytochrome P450 1A2enzyme
DB00370MirtazapineCytochrome P450 3A4enzyme
DB00370MirtazapineCytochrome P450 2D6enzyme
DB00370MirtazapineAlpha-1 adrenergic receptorstarget
DB00370MirtazapineSodium-dependent serotonin transportertransporter
DrugDrug NamePhaseStatusCount
DB01076Atorvastatin1Completed1
DB01065Melatonin1Completed1
DB00333Methadone1Terminated1
DB14822SB-6498681Completed1
DB00641Simvastatin1Completed1
DB00843Donepezil2Completed1
DB01065Melatonin2Completed2
DB01065Melatonin2Withdrawn1
DB11949Vestipitant2Completed1
DB01065Melatonin2 / 3Completed1
DB06700Desvenlafaxine3Completed1
DB06678Esmirtazapine3Completed3
DB06678Esmirtazapine3Terminated1
DB00990Exemestane3Completed1
DB00644Gonadorelin3Completed1
DB01065Melatonin3Completed4
DB00370Mirtazapine3Unknown Status1
DB00745Modafinil3Completed1
DB11642Pitolisant3Completed1
DB00457Prazosin3Completed1
DB00230Pregabalin3Completed1
DB00675Tamoxifen3Completed1
DB00656Trazodone3Completed1
DB06825Triptorelin3Completed1
DB00425Zolpidem3Completed1
DB00425Zolpidem3Recruiting1
DB06594Agomelatine4Not Yet Recruiting1
DB06413Armodafinil4Completed1
DB01156Bupropion4Completed1
DB00215Citalopram4Completed1
DB09065Cobicistat4Completed1
DB00633Dexmedetomidine4Recruiting1
DB09101Elvitegravir4Completed1
DB00879Emtricitabine4Completed1
DB01175Escitalopram4Completed1
DB01018Guanfacine4Terminated1
DB01065Melatonin4Completed1
DB04896Milnacipran4Completed1
DB00184Nicotine4Completed1
DB00413Pramipexole4Not Yet Recruiting1
DB00980Ramelteon4Completed1
DB00300Tenofovir disoproxil4Completed1
DB00425Zolpidem4Completed4
DB00490BuspironeNot AvailableEnrolling by Invitation1
DB00190CarbidopaNot AvailableRecruiting1
DB00633DexmedetomidineNot AvailableCompleted1
DB00625EfavirenzNot AvailableCompleted1
DB00625EfavirenzNot AvailableUnknown Status1
DB00494EntacaponeNot AvailableRecruiting1
DB00402EszopicloneNot AvailableCompleted1
DB06414EtravirineNot AvailableCompleted1
DB00588Fluticasone propionateNot AvailableWithdrawn1
DB01235LevodopaNot AvailableRecruiting1
DB00331MetforminNot AvailableActive Not Recruiting1
DB00745ModafinilNot AvailableCompleted1
DB00213PantoprazoleNot AvailableCompleted1
DB00715ParoxetineNot AvailableCompleted1
DB00715ParoxetineNot AvailableTerminated1
DB00457PrazosinNot AvailableCompleted2
DB00457PrazosinNot AvailableTerminated1
DB00818PropofolNot AvailableCompleted1
DB06817RaltegravirNot AvailableUnknown Status1
DB00980RamelteonNot AvailableWithdrawn1
DB00938SalmeterolNot AvailableWithdrawn1
DB00285VenlafaxineNot AvailableCompleted1
DB00425ZolpidemNot AvailableCompleted2