Sleep disorders and disturbances

Also known as: Sleeping Disorders / Sleep Problems / Disorder Sleep / Sleep Disorders / Sleeping Problems / Sleep Problem / Sleep Disorder (Disorder) / Sleep Disorder / Sleep disorder, unspecified / Sleep disorder NOS / Dyssomnia / Dyssomnias / Dyssomnia (disorder) / Dyssomnia NOS

DrugDrug NameDrug Description
DB00321AmitriptylineA tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression associated anxiety.
DB01594CinolazepamA benzodiazepine used to manage severe and debilitating forms of sleep disorders of various origins in adults.
DB01511DelorazepamA benzodiazepine used to manage severe anxiety disorders and insomnia.
DB13872LormetazepamA benzodiazepine indicated in the treatment of anxiety and the induction of anesthesia.
DB09224MelperoneAn atypical butyrophenone antipsychotic used to treat sleep disorders, confusion, and psychomotor dysfunction associated with geriatric, psychiatric, and alcohol-dependent patients.
DB00370MirtazapineA tetracyclic antidepressant used in the treatment of major depression and is used off-label as a drug for insomnia and to increase appetite.
DB13974Passiflora incarnata flowerA herbal product indicated in the treatment of stress, nervousness, anxiety, irritability, and trouble sleeping.
DrugDrug NameTargetType
DB00321AmitriptylineSodium-dependent serotonin transportertarget
DB00321AmitriptylineSodium-dependent noradrenaline transportertarget
DB00321AmitriptylinePotassium voltage-gated channel subfamily KQT member 2target
DB00321AmitriptylineAlpha-2A adrenergic receptortarget
DB00321AmitriptylineCytochrome P450 1A2enzyme
DB00321AmitriptylineCytochrome P450 2C19enzyme
DB00321AmitriptylineCytochrome P450 2D6enzyme
DB00321AmitriptylineSerum albumincarrier
DB00321AmitriptylineAlpha-1-acid glycoprotein 1carrier
DB00321AmitriptylineHistamine H1 receptortarget
DB00321Amitriptyline5-hydroxytryptamine receptor 2Atarget
DB00321Amitriptyline5-hydroxytryptamine receptor 1Atarget
DB00321AmitriptylineAlpha-1A adrenergic receptortarget
DB00321AmitriptylineCytochrome P450 3A4enzyme
DB00321AmitriptylineCytochrome P450 3A5enzyme
DB00321AmitriptylinePotassium voltage-gated channel subfamily A member 1target
DB00321AmitriptylineAlpha-1D adrenergic receptortarget
DB00321AmitriptylineDelta-type opioid receptortarget
DB00321AmitriptylineKappa-type opioid receptortarget
DB00321AmitriptylineHigh affinity nerve growth factor receptortarget
DB00321AmitriptylineBDNF/NT-3 growth factors receptortarget
DB00321AmitriptylineCytochrome P450 2C9enzyme
DB00321AmitriptylineCytochrome P450 2B6enzyme
DB00321AmitriptylineCytochrome P450 2C8enzyme
DB00321AmitriptylineHistamine H2 receptortarget
DB00321AmitriptylineHistamine H4 receptortarget
DB00321AmitriptylineSigma non-opioid intracellular receptor 1target
DB00321Amitriptyline5-hydroxytryptamine receptor 2Ctarget
DB00321AmitriptylineAlpha-1B adrenergic receptortarget
DB00321Amitriptyline5-hydroxytryptamine receptor 7target
DB00321Amitriptyline5-hydroxytryptamine receptor 1Dtarget
DB00321AmitriptylineMu-type opioid receptortarget
DB00321Amitriptyline5-hydroxytryptamine receptor 1Btarget
DB00321Amitriptyline5-hydroxytryptamine receptor 6target
DB00321AmitriptylinePotassium voltage-gated channel subfamily KQT member 3target
DB00321AmitriptylineUDP-glucuronosyltransferase 2B10enzyme
DB00321Amitriptyline5-hydroxytryptamine receptor 1Ctarget
DB00321AmitriptylineMuscarinic acetylcholine receptortarget
DB00321AmitriptylineHERG human cardiac K+ channeltarget
DB00321AmitriptylineP-glycoprotein 1transporter
DB00321AmitriptylineUDP-glucuronosyltransferase 1-4enzyme
DB00321AmitriptylineGlutathione S-transferases (Cytosolic)enzyme
DB01594CinolazepamGABA(A) Receptortarget
DB01594CinolazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
DB01511DelorazepamGABA(A) Receptortarget
DB01511DelorazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
DB13872LormetazepamGABA(A) Receptortarget
DB13872LormetazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
DB09224MelperoneDopamine D2 receptortarget
DB09224MelperoneCytochrome P450 2D6enzyme
DB00370Mirtazapine5-hydroxytryptamine receptor 2Atarget
DB00370Mirtazapine5HT3 serotonin receptortarget
DB00370MirtazapineAlpha-2A adrenergic receptortarget
DB00370Mirtazapine5-hydroxytryptamine receptor 2Ctarget
DB00370MirtazapineKappa-type opioid receptortarget
DB00370MirtazapineHistamine H1 receptortarget
DB00370MirtazapineCytochrome P450 1A2enzyme
DB00370MirtazapineCytochrome P450 3A4enzyme
DB00370MirtazapineCytochrome P450 2D6enzyme
DB00370MirtazapineAlpha-1 adrenergic receptorstarget
DB00370MirtazapineSodium-dependent serotonin transportertransporter
DrugDrug NamePhaseStatusCount
DB01076Atorvastatin1Completed1
DB01065Melatonin1Completed1
DB00333Methadone1Terminated1
DB00818Propofol1Completed1
DB14822SB-6498681Completed1
DB00641Simvastatin1Completed1
DB17743Fecal microbiota1 / 2Active Not Recruiting1
DB00425Zolpidem1 / 2Completed1
DB00843Donepezil2Completed1
DB00402Eszopiclone2Recruiting1
DB11757Istradefylline2Completed1
DB01065Melatonin2Active Not Recruiting1
DB01065Melatonin2Completed3
DB01065Melatonin2Withdrawn1
DB00422Methylphenidate2Active Not Recruiting1
DB00980Ramelteon2Completed1
DB08869Tesamorelin2Withdrawn1
DB11949Vestipitant2Completed1
DB00962Zaleplon2Completed1
DB01065Melatonin2 / 3Completed1
DB01065Melatonin2 / 3Unknown Status1
DB00413Pramipexole2 / 3Recruiting1
DB00122Choline3Completed1
DB06700Desvenlafaxine3Completed1
DB06678Esmirtazapine3Completed3
DB06678Esmirtazapine3Terminated1
DB00990Exemestane3Completed1
DB00644Gonadorelin3Completed1
DB01065Melatonin3Completed4
DB00370Mirtazapine3Unknown Status1
DB00745Modafinil3Completed1
DB11642Pitolisant3Completed1
DB00457Prazosin3Completed1
DB00230Pregabalin3Completed1
DB00936Salicylic acid3Recruiting1
DB00675Tamoxifen3Completed1
DB09071Tasimelteon3Recruiting1
DB00656Trazodone3Completed2
DB06825Triptorelin3Completed1
DB00425Zolpidem3Completed2
DB06594Agomelatine4Unknown Status1
DB06413Armodafinil4Completed1
DB01156Bupropion4Completed1
DB00215Citalopram4Completed1
DB09065Cobicistat4Completed1
DB00633Dexmedetomidine4Completed1
DB00633Dexmedetomidine4Not Yet Recruiting1
DB00633Dexmedetomidine4Recruiting1
DB09101Elvitegravir4Completed1
DB00879Emtricitabine4Completed1
DB01175Escitalopram4Completed1
DB00402Eszopiclone4Completed1
DB00813Fentanyl4Recruiting1
DB13257Ferrous sulfate anhydrous4Enrolling by Invitation1
DB14041Fremanezumab4Recruiting1
DB01018Guanfacine4Terminated1
DB00465Ketorolac4Recruiting1
DB01065Melatonin4Completed1
DB01065Melatonin4Recruiting1
DB01065Melatonin4Terminated1
DB04896Milnacipran4Completed1
DB14512Mometasone furoate4Completed1
DB00295Morphine4Recruiting1
DB00184Nicotine4Completed1
DB00413Pramipexole4Unknown Status1
DB00818Propofol4Not Yet Recruiting1
DB13331Pyrithyldione4Completed1
DB00980Ramelteon4Completed1
DB09034Suvorexant4Completed2
DB00300Tenofovir disoproxil4Completed1
DB09070Tibolone4Not Yet Recruiting1
DB00656Trazodone4Terminated1
DB00425Zolpidem4Completed4
DB00190CarbidopaNot AvailableUnknown Status1
DB00633DexmedetomidineNot AvailableCompleted1
DB00625EfavirenzNot AvailableCompleted1
DB00625EfavirenzNot AvailableUnknown Status1
DB00494EntacaponeNot AvailableUnknown Status1
DB00402EszopicloneNot AvailableCompleted1
DB06414EtravirineNot AvailableCompleted1
DB00588Fluticasone propionateNot AvailableWithdrawn1
DB01235LevodopaNot AvailableUnknown Status1
DB01065MelatoninNot AvailableTerminated1
DB00331MetforminNot AvailableUnknown Status1
DB00745ModafinilNot AvailableCompleted1
DB12930OpipramolNot AvailableEnrolling by Invitation1
DB00213PantoprazoleNot AvailableCompleted1
DB00715ParoxetineNot AvailableCompleted1
DB00715ParoxetineNot AvailableTerminated1
DB00457PrazosinNot AvailableCompleted2
DB00457PrazosinNot AvailableTerminated1
DB00230PregabalinNot AvailableRecruiting1
DB00818PropofolNot AvailableCompleted1
DB06817RaltegravirNot AvailableUnknown Status1
DB00980RamelteonNot AvailableWithdrawn1
DB00938SalmeterolNot AvailableWithdrawn1
DB00675TamoxifenNot AvailableUnknown Status1
DB00285VenlafaxineNot AvailableCompleted1
DB00425ZolpidemNot AvailableCompleted2
DB00425ZolpidemNot AvailableRecruiting1
DB00425ZolpidemNot AvailableUnknown Status1
DB02530gamma-Aminobutyric acidNot AvailableCompleted1