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Identification
NameDihydrotestosterone
Accession NumberDB02901  (EXPT01199)
TypeSmall Molecule
GroupsIllicit
DescriptionA potent androgenic metabolite of testosterone. Dihydrotestosterone (DHT) is generated by a 5-alpha reduction of testosterone. Unlike testosterone, DHT cannot be aromatized to estradiol therefore DHT is considered a pure androgenic steroid. [PubChem]
Structure
Thumb
Synonyms
17beta-Hydroxy-5alpha-androstan-3-one
17beta-Hydroxy-5alpha-androstane-3-one
17beta-Hydroxyandrostan-3-one
17β-hydroxy-3-oxo-5α-androstanone
17β-hydroxy-5α-androstan-3-one
4-Dihydrotestosterone
5alpha-Dihydrotestosterone
5α-DHT
Androstanolone
DHT
Dihydrotestosteron
Dihydrotestostérone
Stanolone
External Identifiers Not Available
Approved Prescription ProductsNot Available
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
AnaboleenNot Available
AnabolexNot Available
AnaprotinNot Available
AndractimNot Available
AndroloneNot Available
Cristerona MBNot Available
NeodrolNot Available
ProteinaNot Available
ProtonaNot Available
StanaprolNot Available
Brand mixturesNot Available
SaltsNot Available
Categories
UNII08J2K08A3Y
CAS number521-18-6
WeightAverage: 290.4403
Monoisotopic: 290.224580204
Chemical FormulaC19H30O2
InChI KeyNVKAWKQGWWIWPM-ABEVXSGRSA-N
InChI
InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1
IUPAC Name
(1S,2S,7S,10R,11S,14S,15S)-14-hydroxy-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-5-one
SMILES
[H][C@@]12CC[[email protected]](O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])CC(=O)CC[C@]12C
Pharmacology
IndicationNot Available
Structured Indications Not Available
PharmacodynamicsNot Available
Mechanism of action
TargetKindPharmacological actionActionsOrganismUniProt ID
Androgen receptorProteinunknownNot AvailableHumanP10275 details
Estradiol 17-beta-dehydrogenase 1ProteinunknownNot AvailableHumanP14061 details
Related Articles
AbsorptionBioavailability is very low (0-2%) following oral administration.
Volume of distributionNot Available
Protein bindingNot Available
Metabolism
SubstrateEnzymesProduct
Dihydrotestosterone
Not Available
11-Oxo-androsterone glucuronideDetails
Dihydrotestosterone
Not Available
3-alpha-Androstanediol glucuronideDetails
Dihydrotestosterone
Not Available
11-beta-Hydroxyandrosterone-3-glucuronideDetails
Route of eliminationNot Available
Half lifeNot Available
ClearanceNot Available
ToxicityOral LD50 in rat is 7060 mg/kg. Oral LD50 in mouse is 3450 mg/kg.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
16-Bromoepiandrosterone16-Bromoepiandrosterone may increase the fluid retaining activities of Dihydrotestosterone.Investigational
19-norandrostenedione19-norandrostenedione may increase the fluid retaining activities of Dihydrotestosterone.Experimental, Illicit
4-Androstenedione4-Androstenedione may increase the fluid retaining activities of Dihydrotestosterone.Experimental, Illicit
5-androstenedione5-androstenedione may increase the fluid retaining activities of Dihydrotestosterone.Experimental, Illicit
AcarboseDihydrotestosterone may increase the hypoglycemic activities of Acarbose.Approved, Investigational
AcenocoumarolDihydrotestosterone may increase the anticoagulant activities of Acenocoumarol.Approved
AcetaminophenThe serum concentration of Dihydrotestosterone can be increased when it is combined with Acetaminophen.Approved
AfatinibThe serum concentration of Dihydrotestosterone can be increased when it is combined with Afatinib.Approved
AlbendazoleThe serum concentration of Dihydrotestosterone can be increased when it is combined with Albendazole.Approved, Vet Approved
AlbiglutideDihydrotestosterone may increase the hypoglycemic activities of Albiglutide.Approved
AlclometasoneAlclometasone may increase the fluid retaining activities of Dihydrotestosterone.Approved
AldosteroneThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Aldosterone.Experimental
AlectinibThe serum concentration of Dihydrotestosterone can be increased when it is combined with Alectinib.Approved
AlfentanilThe serum concentration of Dihydrotestosterone can be increased when it is combined with Alfentanil.Approved, Illicit
AlogliptinDihydrotestosterone may increase the hypoglycemic activities of Alogliptin.Approved
AmantadineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Amantadine.Approved
AmcinonideAmcinonide may increase the fluid retaining activities of Dihydrotestosterone.Approved
Aminohippuric acidThe serum concentration of Dihydrotestosterone can be increased when it is combined with Aminohippuric acid.Approved
AmiodaroneThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Amiodarone.Approved, Investigational
AmitriptylineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Amitriptyline.Approved
AmlodipineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Amlodipine.Approved
AmprenavirThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Amprenavir.Approved
AmsacrineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Amsacrine.Approved
AnecortaveAnecortave may increase the fluid retaining activities of Dihydrotestosterone.Investigational
AstemizoleThe serum concentration of Dihydrotestosterone can be increased when it is combined with Astemizole.Approved, Withdrawn
AtazanavirThe serum concentration of Dihydrotestosterone can be increased when it is combined with Atazanavir.Approved, Investigational
AtenololThe serum concentration of Dihydrotestosterone can be increased when it is combined with Atenolol.Approved
AtorvastatinThe serum concentration of Dihydrotestosterone can be increased when it is combined with Atorvastatin.Approved
AzelastineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Azelastine.Approved
AzithromycinThe serum concentration of Dihydrotestosterone can be increased when it is combined with Azithromycin.Approved
BeclomethasoneBeclomethasone may increase the fluid retaining activities of Dihydrotestosterone.Investigational
Beclomethasone dipropionateBeclomethasone dipropionate may increase the fluid retaining activities of Dihydrotestosterone.Approved, Investigational
BenzocaineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Benzocaine.Approved
BepridilThe serum concentration of Dihydrotestosterone can be increased when it is combined with Bepridil.Approved, Withdrawn
BetamethasoneBetamethasone may increase the fluid retaining activities of Dihydrotestosterone.Approved, Vet Approved
BiperidenThe serum concentration of Dihydrotestosterone can be increased when it is combined with Biperiden.Approved
BosutinibThe serum concentration of Dihydrotestosterone can be increased when it is combined with Bosutinib.Approved
BromocriptineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Bromocriptine.Approved, Investigational
BudesonideBudesonide may increase the fluid retaining activities of Dihydrotestosterone.Approved
BuprenorphineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe serum concentration of Dihydrotestosterone can be increased when it is combined with Buspirone.Approved, Investigational
C1 Esterase Inhibitor (Human)Dihydrotestosterone may increase the thrombogenic activities of C1 Esterase Inhibitor (Human).Approved
C1 Esterase Inhibitor (Recombinant)Dihydrotestosterone may increase the thrombogenic activities of C1 Esterase Inhibitor (Recombinant).Approved
CabazitaxelThe serum concentration of Dihydrotestosterone can be increased when it is combined with Cabazitaxel.Approved
CaffeineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Caffeine.Approved
CanagliflozinThe serum concentration of Dihydrotestosterone can be increased when it is combined with Canagliflozin.Approved
CandesartanThe serum concentration of Dihydrotestosterone can be increased when it is combined with Candesartan.Approved
CaptoprilThe serum concentration of Dihydrotestosterone can be increased when it is combined with Captopril.Approved
CarbamazepineThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Carbamazepine.Approved, Investigational
CarvedilolThe serum concentration of Dihydrotestosterone can be increased when it is combined with Carvedilol.Approved, Investigational
CaspofunginThe serum concentration of Dihydrotestosterone can be increased when it is combined with Caspofungin.Approved
ChloroquineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Chloroquine.Approved, Vet Approved
ChlorpromazineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Chlorpromazine.Approved, Vet Approved
ChlorpropamideThe serum concentration of Dihydrotestosterone can be increased when it is combined with Chlorpropamide.Approved
ChlorprothixeneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Chlorprothixene.Approved, Withdrawn
CholesterolThe serum concentration of Dihydrotestosterone can be increased when it is combined with Cholesterol.Experimental
Cholic AcidThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Cholic Acid.Approved
CiclesonideCiclesonide may increase the fluid retaining activities of Dihydrotestosterone.Approved, Investigational
CilazaprilThe serum concentration of Dihydrotestosterone can be increased when it is combined with Cilazapril.Approved
CimetidineThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Cimetidine.Approved
CiprofloxacinThe serum concentration of Dihydrotestosterone can be increased when it is combined with Ciprofloxacin.Approved, Investigational
CitalopramThe serum concentration of Dihydrotestosterone can be increased when it is combined with Citalopram.Approved
ClarithromycinThe serum concentration of Dihydrotestosterone can be increased when it is combined with Clarithromycin.Approved
ClobetasolClobetasol may increase the fluid retaining activities of Dihydrotestosterone.Investigational
Clobetasol propionateClobetasol propionate may increase the fluid retaining activities of Dihydrotestosterone.Approved
ClocortoloneClocortolone may increase the fluid retaining activities of Dihydrotestosterone.Approved
ClofazimineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Clofazimine.Approved, Investigational
ClomipramineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Clomipramine.Approved, Vet Approved
ClotrimazoleThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Clotrimazole.Approved, Vet Approved
CobicistatThe serum concentration of Dihydrotestosterone can be increased when it is combined with Cobicistat.Approved
ColchicineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Colchicine.Approved
ColforsinThe serum concentration of Dihydrotestosterone can be increased when it is combined with Colforsin.Experimental
Cortisone acetateCortisone acetate may increase the fluid retaining activities of Dihydrotestosterone.Approved
CrizotinibThe serum concentration of Dihydrotestosterone can be increased when it is combined with Crizotinib.Approved
CyclophosphamideThe serum concentration of Dihydrotestosterone can be increased when it is combined with Cyclophosphamide.Approved, Investigational
CyclosporineDihydrotestosterone may increase the hepatotoxic activities of Cyclosporine.Approved, Investigational, Vet Approved
CyclosporineThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Cyclosporine.Approved, Investigational, Vet Approved
DaclatasvirThe serum concentration of Dihydrotestosterone can be increased when it is combined with Daclatasvir.Approved
DactinomycinThe serum concentration of Dihydrotestosterone can be increased when it is combined with Dactinomycin.Approved
DapagliflozinDihydrotestosterone may increase the hypoglycemic activities of Dapagliflozin.Approved
DasatinibThe serum concentration of Dihydrotestosterone can be increased when it is combined with Dasatinib.Approved, Investigational
DaunorubicinThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Daunorubicin.Approved
dehydroepiandrosterone sulfatedehydroepiandrosterone sulfate may increase the fluid retaining activities of Dihydrotestosterone.Investigational
DesipramineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Desipramine.Approved
DesloratadineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Desloratadine.Approved, Investigational
DesoximetasoneDesoximetasone may increase the fluid retaining activities of Dihydrotestosterone.Approved
Desoxycorticosterone acetateDesoxycorticosterone acetate may increase the fluid retaining activities of Dihydrotestosterone.Approved
Desoxycorticosterone PivalateDesoxycorticosterone Pivalate may increase the fluid retaining activities of Dihydrotestosterone.Experimental, Vet Approved
DexamethasoneThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
Dexamethasone isonicotinateDexamethasone isonicotinate may increase the fluid retaining activities of Dihydrotestosterone.Vet Approved
DextromethorphanThe serum concentration of Dihydrotestosterone can be increased when it is combined with Dextromethorphan.Approved
DiclofenacThe serum concentration of Dihydrotestosterone can be increased when it is combined with Diclofenac.Approved, Vet Approved
DicoumarolDihydrotestosterone may increase the anticoagulant activities of Dicoumarol.Approved
DiflorasoneDiflorasone may increase the fluid retaining activities of Dihydrotestosterone.Approved
DifluocortoloneDifluocortolone may increase the fluid retaining activities of Dihydrotestosterone.Approved
DifluprednateDifluprednate may increase the fluid retaining activities of Dihydrotestosterone.Approved
DigoxinThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Digoxin.Approved
DihydroergotamineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Dihydroergotamine.Approved
DiltiazemThe serum concentration of Dihydrotestosterone can be increased when it is combined with Diltiazem.Approved
DipyridamoleThe serum concentration of Dihydrotestosterone can be increased when it is combined with Dipyridamole.Approved
DisopyramideDihydrotestosterone may increase the hypoglycemic activities of Disopyramide.Approved
DoxazosinThe serum concentration of Dihydrotestosterone can be increased when it is combined with Doxazosin.Approved
DoxepinThe serum concentration of Dihydrotestosterone can be increased when it is combined with Doxepin.Approved
DoxorubicinThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Doxorubicin.Approved, Investigational
DronabinolThe serum concentration of Dihydrotestosterone can be increased when it is combined with Dronabinol.Approved, Illicit
DronedaroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Dronedarone.Approved
DulaglutideDihydrotestosterone may increase the hypoglycemic activities of Dulaglutide.Approved
ElbasvirThe serum concentration of Dihydrotestosterone can be increased when it is combined with Elbasvir.Approved
EmpagliflozinDihydrotestosterone may increase the hypoglycemic activities of Empagliflozin.Approved
EnalaprilThe serum concentration of Dihydrotestosterone can be increased when it is combined with Enalapril.Approved, Vet Approved
EnzalutamideThe serum concentration of Dihydrotestosterone can be increased when it is combined with Enzalutamide.Approved
EquileninEquilenin may increase the fluid retaining activities of Dihydrotestosterone.Experimental
EquilinEquilin may increase the fluid retaining activities of Dihydrotestosterone.Approved
ErgonovineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Ergonovine.Approved
ErgotamineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Ergotamine.Approved
ErythromycinThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Erythromycin.Approved, Vet Approved
EstramustineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Estramustine.Approved
EstriolThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Estriol.Approved, Vet Approved
EstroneThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Estrone.Approved
Estrone sulfateEstrone sulfate may increase the fluid retaining activities of Dihydrotestosterone.Approved
Ethyl biscoumacetateDihydrotestosterone may increase the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
EtoposideThe serum concentration of Dihydrotestosterone can be increased when it is combined with Etoposide.Approved
EtravirineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Etravirine.Approved
ExenatideDihydrotestosterone may increase the hypoglycemic activities of Exenatide.Approved, Investigational
FelodipineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Felodipine.Approved, Investigational
FentanylThe serum concentration of Dihydrotestosterone can be increased when it is combined with Fentanyl.Approved, Illicit, Investigational, Vet Approved
FexofenadineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Fexofenadine.Approved
FidaxomicinThe serum concentration of Dihydrotestosterone can be increased when it is combined with Fidaxomicin.Approved
fluasteronefluasterone may increase the fluid retaining activities of Dihydrotestosterone.Investigational
FluconazoleThe serum concentration of Dihydrotestosterone can be increased when it is combined with Fluconazole.Approved
FludrocortisoneFludrocortisone may increase the fluid retaining activities of Dihydrotestosterone.Approved
FluindioneDihydrotestosterone may increase the anticoagulant activities of Fluindione.Investigational
FlumethasoneFlumethasone may increase the fluid retaining activities of Dihydrotestosterone.Approved, Vet Approved
FlunisolideFlunisolide may increase the fluid retaining activities of Dihydrotestosterone.Approved, Investigational
Fluocinolone AcetonideFluocinolone Acetonide may increase the fluid retaining activities of Dihydrotestosterone.Approved, Investigational, Vet Approved
FluocinonideFluocinonide may increase the fluid retaining activities of Dihydrotestosterone.Approved, Investigational
FluocortoloneFluocortolone may increase the fluid retaining activities of Dihydrotestosterone.Approved, Withdrawn
FluorometholoneFluorometholone may increase the fluid retaining activities of Dihydrotestosterone.Approved
FluoxetineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe serum concentration of Dihydrotestosterone can be increased when it is combined with Flupentixol.Approved, Withdrawn
FluphenazineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Fluphenazine.Approved
FluprednideneFluprednidene may increase the fluid retaining activities of Dihydrotestosterone.Approved, Withdrawn
FluprednisoloneFluprednisolone may increase the fluid retaining activities of Dihydrotestosterone.Approved
FlurandrenolideFlurandrenolide may increase the fluid retaining activities of Dihydrotestosterone.Approved
FlurazepamThe serum concentration of Dihydrotestosterone can be increased when it is combined with Flurazepam.Approved, Illicit
Fluticasone furoateFluticasone furoate may increase the fluid retaining activities of Dihydrotestosterone.Approved
Fluticasone PropionateFluticasone Propionate may increase the fluid retaining activities of Dihydrotestosterone.Approved
FluvoxamineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Fluvoxamine.Approved, Investigational
FormestaneFormestane may increase the fluid retaining activities of Dihydrotestosterone.Approved, Investigational, Withdrawn
GefitinibThe serum concentration of Dihydrotestosterone can be increased when it is combined with Gefitinib.Approved, Investigational
GenisteinThe serum concentration of Dihydrotestosterone can be increased when it is combined with Genistein.Investigational
GliclazideDihydrotestosterone may increase the hypoglycemic activities of Gliclazide.Approved
GlimepirideDihydrotestosterone may increase the hypoglycemic activities of Glimepiride.Approved
GlipizideDihydrotestosterone may increase the hypoglycemic activities of Glipizide.Approved
GlyburideThe serum concentration of Dihydrotestosterone can be increased when it is combined with Glyburide.Approved
GlycerolThe serum concentration of Dihydrotestosterone can be increased when it is combined with Glycerol.Experimental
Gramicidin DThe serum concentration of Dihydrotestosterone can be increased when it is combined with Gramicidin D.Approved
GrepafloxacinThe serum concentration of Dihydrotestosterone can be increased when it is combined with Grepafloxacin.Withdrawn
HaloperidolThe serum concentration of Dihydrotestosterone can be increased when it is combined with Haloperidol.Approved
HE3286HE3286 may increase the fluid retaining activities of Dihydrotestosterone.Investigational
HydrocortisoneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Hydrocortisone.Approved, Vet Approved
IdelalisibThe serum concentration of Dihydrotestosterone can be increased when it is combined with Idelalisib.Approved
ImatinibThe serum concentration of Dihydrotestosterone can be increased when it is combined with Imatinib.Approved
ImipramineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Imipramine.Approved
IndinavirThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Indinavir.Approved
IndomethacinThe serum concentration of Dihydrotestosterone can be increased when it is combined with Indomethacin.Approved, Investigational
Insulin AspartDihydrotestosterone may increase the hypoglycemic activities of Insulin Aspart.Approved
Insulin DetemirDihydrotestosterone may increase the hypoglycemic activities of Insulin Detemir.Approved
Insulin GlargineDihydrotestosterone may increase the hypoglycemic activities of Insulin Glargine.Approved
Insulin GlulisineDihydrotestosterone may increase the hypoglycemic activities of Insulin Glulisine.Approved
Insulin HumanDihydrotestosterone may increase the hypoglycemic activities of Insulin Human.Approved, Investigational
Insulin LisproDihydrotestosterone may increase the hypoglycemic activities of Insulin Lispro.Approved
IsavuconazoniumThe serum concentration of Dihydrotestosterone can be increased when it is combined with Isavuconazonium.Approved, Investigational
IstaroximeIstaroxime may increase the fluid retaining activities of Dihydrotestosterone.Investigational
ItraconazoleThe serum concentration of Dihydrotestosterone can be increased when it is combined with Itraconazole.Approved, Investigational
IvacaftorThe serum concentration of Dihydrotestosterone can be increased when it is combined with Ivacaftor.Approved
IvermectinThe serum concentration of Dihydrotestosterone can be increased when it is combined with Ivermectin.Approved, Vet Approved
KetamineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Ketamine.Approved, Vet Approved
KetoconazoleThe serum concentration of Dihydrotestosterone can be increased when it is combined with Ketoconazole.Approved, Investigational
LanreotideDihydrotestosterone may increase the hypoglycemic activities of Lanreotide.Approved
LansoprazoleThe serum concentration of Dihydrotestosterone can be increased when it is combined with Lansoprazole.Approved, Investigational
LapatinibThe serum concentration of Dihydrotestosterone can be increased when it is combined with Lapatinib.Approved, Investigational
LevofloxacinThe serum concentration of Dihydrotestosterone can be increased when it is combined with Levofloxacin.Approved, Investigational
LevothyroxineThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Levothyroxine.Approved
LidocaineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Lidocaine.Approved, Vet Approved
LiothyronineThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Liothyronine.Approved, Vet Approved
LiotrixThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Liotrix.Approved
LiraglutideDihydrotestosterone may increase the hypoglycemic activities of Liraglutide.Approved
LisinoprilThe serum concentration of Dihydrotestosterone can be increased when it is combined with Lisinopril.Approved, Investigational
LomitapideThe serum concentration of Dihydrotestosterone can be increased when it is combined with Lomitapide.Approved
LoperamideThe serum concentration of Dihydrotestosterone can be increased when it is combined with Loperamide.Approved
LopinavirThe serum concentration of Dihydrotestosterone can be increased when it is combined with Lopinavir.Approved
LoratadineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Loratadine.Approved
LosartanThe serum concentration of Dihydrotestosterone can be increased when it is combined with Losartan.Approved
LovastatinThe serum concentration of Dihydrotestosterone can be increased when it is combined with Lovastatin.Approved, Investigational
LumacaftorThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Lumacaftor.Approved
MaprotilineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Maprotiline.Approved
ME-609ME-609 may increase the fluid retaining activities of Dihydrotestosterone.Investigational
MebendazoleThe serum concentration of Dihydrotestosterone can be increased when it is combined with Mebendazole.Approved, Vet Approved
MecaserminDihydrotestosterone may increase the hypoglycemic activities of Mecasermin.Approved, Investigational
MedrysoneMedrysone may increase the fluid retaining activities of Dihydrotestosterone.Approved
MefloquineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Mefloquine.Approved
Megestrol acetateThe serum concentration of Dihydrotestosterone can be increased when it is combined with Megestrol acetate.Approved, Vet Approved
MelengestrolMelengestrol may increase the fluid retaining activities of Dihydrotestosterone.Vet Approved
MeprobamateThe serum concentration of Dihydrotestosterone can be increased when it is combined with Meprobamate.Approved, Illicit
MetforminDihydrotestosterone may increase the hypoglycemic activities of Metformin.Approved
MethadoneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Methadone.Approved
MethylprednisoloneMethylprednisolone may increase the fluid retaining activities of Dihydrotestosterone.Approved, Vet Approved
MetoprololThe serum concentration of Dihydrotestosterone can be increased when it is combined with Metoprolol.Approved, Investigational
MibefradilThe serum concentration of Dihydrotestosterone can be increased when it is combined with Mibefradil.Withdrawn
MiconazoleThe serum concentration of Dihydrotestosterone can be increased when it is combined with Miconazole.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Midazolam.Approved, Illicit
MifepristoneThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Mifepristone.Approved, Investigational
MiglitolDihydrotestosterone may increase the hypoglycemic activities of Miglitol.Approved
MitomycinThe serum concentration of Dihydrotestosterone can be increased when it is combined with Mitomycin.Approved
MitoxantroneThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Mitoxantrone.Approved, Investigational
MometasoneMometasone may increase the fluid retaining activities of Dihydrotestosterone.Approved, Vet Approved
MorphineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Morphine.Approved, Investigational
NaltrexoneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Naltrexone.Approved, Investigational, Vet Approved
NaringeninThe serum concentration of Dihydrotestosterone can be increased when it is combined with Naringenin.Experimental
NateglinideDihydrotestosterone may increase the hypoglycemic activities of Nateglinide.Approved, Investigational
NCX 1022NCX 1022 may increase the fluid retaining activities of Dihydrotestosterone.Investigational
NefazodoneThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Nefazodone.Approved, Withdrawn
NelfinavirThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Nelfinavir.Approved
NeostigmineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Neostigmine.Approved, Vet Approved
NicardipineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Nicardipine.Approved
NifedipineThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Nifedipine.Approved
NilotinibThe serum concentration of Dihydrotestosterone can be increased when it is combined with Nilotinib.Approved, Investigational
NisoldipineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Nisoldipine.Approved
NitrazepamThe serum concentration of Dihydrotestosterone can be increased when it is combined with Nitrazepam.Approved
NitrendipineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Nitrendipine.Approved
NorethisteroneThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Norethisterone.Approved
OctreotideDihydrotestosterone may increase the hypoglycemic activities of Octreotide.Approved, Investigational
Oleoyl estroneOleoyl estrone may increase the fluid retaining activities of Dihydrotestosterone.Investigational
OmeprazoleThe serum concentration of Dihydrotestosterone can be increased when it is combined with Omeprazole.Approved, Investigational, Vet Approved
P-NitrophenolThe serum concentration of Dihydrotestosterone can be increased when it is combined with P-Nitrophenol.Experimental
PaclitaxelThe serum concentration of Dihydrotestosterone can be increased when it is combined with Paclitaxel.Approved, Vet Approved
Palmitic AcidThe serum concentration of Dihydrotestosterone can be increased when it is combined with Palmitic Acid.Experimental
PantoprazoleThe serum concentration of Dihydrotestosterone can be increased when it is combined with Pantoprazole.Approved
ParamethasoneParamethasone may increase the fluid retaining activities of Dihydrotestosterone.Approved
ParoxetineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Paroxetine.Approved, Investigational
PasireotideDihydrotestosterone may increase the hypoglycemic activities of Pasireotide.Approved
PentamidineDihydrotestosterone may increase the hypoglycemic activities of Pentamidine.Approved
PerindoprilThe serum concentration of Dihydrotestosterone can be increased when it is combined with Perindopril.Approved
PhenindioneDihydrotestosterone may increase the anticoagulant activities of Phenindione.Approved
PhenobarbitalThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Phenobarbital.Approved
PhenprocoumonDihydrotestosterone may increase the anticoagulant activities of Phenprocoumon.Approved
PimozideThe serum concentration of Dihydrotestosterone can be increased when it is combined with Pimozide.Approved
PioglitazoneDihydrotestosterone may increase the hypoglycemic activities of Pioglitazone.Approved, Investigational
Platelet Activating FactorThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Platelet Activating Factor.Experimental
PonatinibThe serum concentration of Dihydrotestosterone can be increased when it is combined with Ponatinib.Approved
PosaconazoleThe serum concentration of Dihydrotestosterone can be increased when it is combined with Posaconazole.Approved, Investigational, Vet Approved
PramlintideDihydrotestosterone may increase the hypoglycemic activities of Pramlintide.Approved, Investigational
PrasteronePrasterone may increase the fluid retaining activities of Dihydrotestosterone.Approved, Nutraceutical
PravastatinThe serum concentration of Dihydrotestosterone can be increased when it is combined with Pravastatin.Approved
PrazosinThe serum concentration of Dihydrotestosterone can be increased when it is combined with Prazosin.Approved
PrednicarbatePrednicarbate may increase the fluid retaining activities of Dihydrotestosterone.Approved
PrednisolonePrednisolone may increase the fluid retaining activities of Dihydrotestosterone.Approved, Vet Approved
PrednisoneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Prednisone.Approved, Vet Approved
PregnenolonePregnenolone may increase the fluid retaining activities of Dihydrotestosterone.Experimental
ProbenecidThe serum concentration of Dihydrotestosterone can be increased when it is combined with Probenecid.Approved
ProgesteroneThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Progesterone.Approved, Vet Approved
PromethazineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Promethazine.Approved
PropafenoneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Propafenone.Approved
PropranololThe serum concentration of Dihydrotestosterone can be increased when it is combined with Propranolol.Approved, Investigational
ProtriptylineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Protriptyline.Approved
QuercetinThe serum concentration of Dihydrotestosterone can be increased when it is combined with Quercetin.Experimental
QuinacrineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Quinacrine.Approved
QuinidineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Quinidine.Approved
QuinineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Quinine.Approved
RanitidineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Ranitidine.Approved
RanolazineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Ranolazine.Approved, Investigational
ReboxetineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Reboxetine.Approved, Investigational
RegorafenibThe serum concentration of Dihydrotestosterone can be increased when it is combined with Regorafenib.Approved
RepaglinideDihydrotestosterone may increase the hypoglycemic activities of Repaglinide.Approved, Investigational
ReserpineThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Reserpine.Approved
RifampicinThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Rifampicin.Approved
RilpivirineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Rilpivirine.Approved
RimexoloneRimexolone may increase the fluid retaining activities of Dihydrotestosterone.Approved
RitonavirThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Ritonavir.Approved, Investigational
RolapitantThe serum concentration of Dihydrotestosterone can be increased when it is combined with Rolapitant.Approved
RosiglitazoneDihydrotestosterone may increase the hypoglycemic activities of Rosiglitazone.Approved, Investigational
SaquinavirThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Saquinavir.Approved, Investigational
SaxagliptinDihydrotestosterone may increase the hypoglycemic activities of Saxagliptin.Approved
ScopolamineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Scopolamine.Approved
SelegilineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Selegiline.Approved, Investigational, Vet Approved
SertralineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Sertraline.Approved
SimeprevirThe serum concentration of Dihydrotestosterone can be increased when it is combined with Simeprevir.Approved
SimvastatinThe serum concentration of Dihydrotestosterone can be increased when it is combined with Simvastatin.Approved
SirolimusThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Sirolimus.Approved, Investigational
SitagliptinDihydrotestosterone may increase the hypoglycemic activities of Sitagliptin.Approved, Investigational
SorafenibThe serum concentration of Dihydrotestosterone can be increased when it is combined with Sorafenib.Approved, Investigational
SpironolactoneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Spironolactone.Approved
St. John's WortThe serum concentration of Dihydrotestosterone can be decreased when it is combined with St. John's Wort.Nutraceutical
StaurosporineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Staurosporine.Experimental
StreptozocinThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Streptozocin.Approved
SulfadiazineDihydrotestosterone may increase the hypoglycemic activities of Sulfadiazine.Approved, Vet Approved
SulfamethoxazoleDihydrotestosterone may increase the hypoglycemic activities of Sulfamethoxazole.Approved
SulfinpyrazoneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Sulfinpyrazone.Approved
SulfisoxazoleDihydrotestosterone may increase the hypoglycemic activities of Sulfisoxazole.Approved, Vet Approved
SumatriptanThe serum concentration of Dihydrotestosterone can be increased when it is combined with Sumatriptan.Approved, Investigational
SunitinibThe serum concentration of Dihydrotestosterone can be increased when it is combined with Sunitinib.Approved, Investigational
TacrineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Tacrine.Withdrawn
TacrolimusThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Tacrolimus.Approved, Investigational
TamoxifenThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Tamoxifen.Approved
Taurocholic AcidThe serum concentration of Dihydrotestosterone can be increased when it is combined with Taurocholic Acid.Experimental
TelmisartanThe serum concentration of Dihydrotestosterone can be increased when it is combined with Telmisartan.Approved, Investigational
TemsirolimusThe serum concentration of Dihydrotestosterone can be increased when it is combined with Temsirolimus.Approved
TerazosinThe serum concentration of Dihydrotestosterone can be increased when it is combined with Terazosin.Approved
TerfenadineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Terfenadine.Withdrawn
TesmilifeneThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Tesmilifene.Investigational
TestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Testosterone.Approved, Investigational
TicagrelorThe serum concentration of Dihydrotestosterone can be increased when it is combined with Ticagrelor.Approved
TixocortolTixocortol may increase the fluid retaining activities of Dihydrotestosterone.Approved
TolazamideDihydrotestosterone may increase the hypoglycemic activities of Tolazamide.Approved
TolbutamideDihydrotestosterone may increase the hypoglycemic activities of Tolbutamide.Approved
TolvaptanThe serum concentration of Dihydrotestosterone can be increased when it is combined with Tolvaptan.Approved
TrazodoneThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Trazodone.Approved, Investigational
TriamcinoloneTriamcinolone may increase the fluid retaining activities of Dihydrotestosterone.Approved, Vet Approved
TrifluoperazineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Trifluoperazine.Approved
TriflupromazineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Triflupromazine.Approved, Vet Approved
TrimethoprimThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Trimethoprim.Approved, Vet Approved
TrimipramineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Trimipramine.Approved
TroleandomycinThe serum concentration of Dihydrotestosterone can be increased when it is combined with Troleandomycin.Approved
VenlafaxineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Venlafaxine.Approved
VerapamilThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Verapamil.Approved
VinblastineThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Vinblastine.Approved
VincristineThe serum concentration of Dihydrotestosterone can be decreased when it is combined with Vincristine.Approved, Investigational
VinorelbineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Vinorelbine.Approved, Investigational
WarfarinDihydrotestosterone may increase the anticoagulant activities of Warfarin.Approved
ZimelidineThe serum concentration of Dihydrotestosterone can be increased when it is combined with Zimelidine.Withdrawn
Food InteractionsNot Available
References
Synthesis Reference

A. Glenn Braswell, Aftab J. Ahmed, “Composition for inhibiting production of dihydrotestosterone to treat benign prostate hyperplasia.” U.S. Patent US6264996, issued October, 1996.

US6264996
General ReferencesNot Available
External Links
ATC CodesA14AA01G03BB02
AHFS CodesNot Available
PDB Entries
FDA labelNot Available
MSDSDownload (111 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+1.0
Blood Brain Barrier+0.9818
Caco-2 permeable+0.8846
P-glycoprotein substrateSubstrate0.57
P-glycoprotein inhibitor INon-inhibitor0.5631
P-glycoprotein inhibitor IINon-inhibitor0.846
Renal organic cation transporterNon-inhibitor0.7884
CYP450 2C9 substrateNon-substrate0.7715
CYP450 2D6 substrateNon-substrate0.93
CYP450 3A4 substrateSubstrate0.7314
CYP450 1A2 substrateNon-inhibitor0.6853
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorNon-inhibitor0.971
CYP450 2C19 inhibitorNon-inhibitor0.9025
CYP450 3A4 inhibitorNon-inhibitor0.8546
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9647
Ames testNon AMES toxic0.9414
CarcinogenicityNon-carcinogens0.9182
BiodegradationNot ready biodegradable0.9686
Rat acute toxicity1.9757 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9444
hERG inhibition (predictor II)Non-inhibitor0.576
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
ManufacturersNot Available
PackagersNot Available
Dosage formsNot Available
PricesNot Available
PatentsNot Available
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point181 °CPhysProp
water solubility5.25E+005 mg/L (at 25 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP3.55HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
Water Solubility0.00998 mg/mLALOGPS
logP3.37ALOGPS
logP3.41ChemAxon
logS-4.5ALOGPS
pKa (Strongest Acidic)19.38ChemAxon
pKa (Strongest Basic)-0.88ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area37.3 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity83.6 m3·mol-1ChemAxon
Polarizability34.69 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (11.2 KB)
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
MSMass Spectrum (Electron Ionization)splash10-000x-9870000000-f6d80b2a53942c9af50bView in MoNA
1D NMR13C NMR SpectrumNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as androgens and derivatives. These are 3-hydroxylated C19 steroid hormones. They are known to favor the development of masculine characteristics. They also show profound effects on scalp and body hair in humans.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassSteroids and steroid derivatives
Sub ClassAndrostane steroids
Direct ParentAndrogens and derivatives
Alternative Parents
Substituents
  • Androgen-skeleton
  • 3-oxo-5-alpha-steroid
  • 17-hydroxysteroid
  • Oxosteroid
  • Hydroxysteroid
  • 3-oxosteroid
  • Cyclohexanone
  • Cyclic alcohol
  • Cyclic ketone
  • Secondary alcohol
  • Ketone
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Alcohol
  • Aliphatic homopolycyclic compound
Molecular FrameworkAliphatic homopolycyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Zinc ion binding
Specific Function:
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
Gene Name:
AR
Uniprot ID:
P10275
Molecular Weight:
98987.9 Da
References
  1. Askew EB, Gampe RT Jr, Stanley TB, Faggart JL, Wilson EM: Modulation of androgen receptor activation function 2 by testosterone and dihydrotestosterone. J Biol Chem. 2007 Aug 31;282(35):25801-16. Epub 2007 Jun 25. [PubMed:17591767 ]
  2. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Testosterone dehydrogenase (nad+) activity
Specific Function:
Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.
Gene Name:
HSD17B1
Uniprot ID:
P14061
Molecular Weight:
34949.715 Da

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, nad(p)h as one donor, and incorporation of one atom of oxygen
Specific Function:
Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.
Gene Name:
CYP11A1
Uniprot ID:
P05108
Molecular Weight:
60101.87 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid 17-alpha-monooxygenase activity
Specific Function:
Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.
Gene Name:
CYP17A1
Uniprot ID:
P05093
Molecular Weight:
57369.995 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Gene Name:
CYP19A1
Uniprot ID:
P11511
Molecular Weight:
57882.48 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Androgen binding
Specific Function:
Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration.
Gene Name:
SHBG
Uniprot ID:
P04278
Molecular Weight:
43778.755 Da
References
  1. Metzger J, Schnitzbauer A, Meyer M, Soder M, Cuilleron CY, Hauptmann H, Huber E, Luppa PB: Binding analysis of 1alpha- and 17alpha-dihydrotestosterone derivatives to homodimeric sex hormone-binding globulin. Biochemistry. 2003 Nov 25;42(46):13735-45. [PubMed:14622020 ]
  2. Hauptmann H, Metzger J, Schnitzbauer A, Cuilleron CY, Mappus E, Luppa PB: Syntheses and ligand-binding studies of 1 alpha- and 17 alpha-aminoalkyl dihydrotestosterone derivatives to human sex hormone-binding globulin. Steroids. 2003 Sep;68(7-8):629-39. [PubMed:12957668 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Fedoruk MN, Gimenez-Bonafe P, Guns ES, Mayer LD, Nelson CC: P-glycoprotein increases the efflux of the androgen dihydrotestosterone and reduces androgen responsive gene activity in prostate tumor cells. Prostate. 2004 Apr 1;59(1):77-90. [PubMed:14991868 ]
Comments
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Drug created on June 13, 2005 07:24 / Updated on August 17, 2016 12:23