Testosterone Congeners

Steroidal compounds related to TESTOSTERONE, the major mammalian male sex hormone. Testosterone congeners include important testosterone precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with androgenic activities.
DrugDrug NameDrug Indication
DB00624TestosteroneTo be used as hormone replacement or substitution of diminished or absent endogenous testosterone. Use in males: For management of congenital or acquired hypogonadism, hypogonadism associated with HIV infection, and male climacteric (andopause). Use in females: For palliative treatment of androgen-responsive, advanced, inoperable, metastatis (skeletal) carcinoma of the breast in women who are 1-5 years postmenopausal; testosterone esters may be used in combination with estrogens in the management of moderate to severe vasomotor symptoms associated with menopause in women who do not respond to adequately to estrogen therapy alone.
DB00717NorethisteroneFor the treatment of secondary amenorrhea, endometriosis, and abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology, such as submucous fibroids or uterine cancer.
DB00984Nandrolone phenpropionateFor the treatment of refractory deficient red cell production anemias, breast carcinoma, hereditary angioedema, antithrombin III deficiency, fibrinogen excess, growth failure and Turner's syndrome. It is also indicated in the prophylaxis of hereditary angioedema.
DB01108TrilostaneUsed in the treatment of Cushing's syndrome. It is normally used in short-term treatment until permanent therapy is possible.
DB01420Testosterone PropionateTestosterone propionate is an anabolic steroid and a short ester form of testosterone that becomes active in the body. It is often used for muscle mass building.
DB0143419-norandrostenedioneThe claim that supplemental 19-norandrostenedione has anabolic effects is unsubstantiated.
DB014565-androstenedioneNot Available
DB01471BolasteroneNot Available
DB01481Delta1-dihydrotestosteroneNot Available
DB01521ClostebolNot Available
DB01524AndrostenediolNot Available
DB01536AndrostenedioneNot Available
DB01541BoldenoneNot Available
DB01554BolandiolNot Available
DB01564CalusteroneAn anabolic steroid which can theoretically aid in restauration and buildup of certain tissues, especially muscle. It is similar to synthetic testosterone and is still in early investigation. It was also investigated for use as a treatment for metastatic breast cancer.
DB01708PrasteroneDHEA is taken as a supplement for a variety of unsubstantiated indications. The following indications have shown promise and are backed up by some scientific evidence: schizophrenia (DHEA may be more effective in women than men); improving the appearance of older people’s skin (taking DHEA by mouth seems to increase skin thickness and moisture, and decrease facial “age spots” in elderly men and women); improving ability to achieve an erection in men with sexual dysfunction. Additionally, DHEA has shown promise in improving symptoms of lupus (SLE). Taking DHEA by mouth along with conventional treatment may help reduce the number of times symptoms flare up and may allow a reduction in the dose of prescription drugs needed. DHEA may also help SLE symptoms such as muscle ache and mouth ulcers. DHEA also seems to strengthen bones in SLE patients being treated with high-dose steroids (corticosteroids). DHEA also shows promise in the treatment of osteoporosis. Taking DHEA by mouth daily seems to improve bone mineral density (BMD) in older women and men with osteoporosis or osteopenia (pre-osteoporosis). DHEA may also increase BMD in young women with the eating disorder called anorexia nervosa. DHEA is often prescribed in India for the induction of ovulation to improve chances of pregnancy.
DB02901DihydrotestosteroneNot Available
DB04468AfimoxifeneFor the potential treatment of menstrual-cycle related mastalgia, fibrocystic breast disease, breast disease, gynecomastia and Keloid scarring.
DB0510716-BromoepiandrosteroneInvestigated for use/treatment in cystic fibrosis, HIV infection, hepatitis (viral, B), and malaria.
DB05212HE3286For the treatment of rheumatoid arthritis and type 2 diabetes.
DB05804Prasterone sulfateInvestigated for use/treatment in asthma and burns and burn infections.
DB06710MethyltestosteroneMethyltestosterone is an anabolic steroid hormone used to treat men with a testosterone deficiency. It is also used in women to treat breast cancer, breast pain, swelling due to pregnancy, and with the addition of estrogen it can treat symptoms of menopause.
DB08619TESTOSTERONE HEMISUCCINATENot Available
DB08804Nandrolone decanoateFor the treatment of refractory deficient red cell production anemias, breast carcinoma, hereditary angioedema, antithrombin III deficiency, fibrinogen excess, growth failure and Turner's syndrome. It is also indicated in the prophylaxis of hereditary angioedema.
DB08905FormestaneFor the treatment of estrogen-receptor positive breast cancer in post-menopausal women.
DB09123DienogestIndicated for use as the treatment of endometriosis alone and as a contraceptive in combination with ethinylestradiol.
DB12194AtamestaneNot Available
DB13169NandroloneNot Available
DB13587MesteroloneNot Available
DrugDrug NameTargetType
DB00624TestosteroneAndrogen receptortarget
DB00624TestosteroneCytochrome P450 3A4enzyme
DB00624TestosteroneCytochrome P450 19A1enzyme
DB00624TestosteroneAmine oxidase [flavin-containing] Aenzyme
DB00624TestosteroneCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DB00624TestosteroneSerum albumincarrier
DB00624TestosteroneSex hormone-binding globulincarrier
DB00624TestosteroneCytochrome P450 3A5enzyme
DB00624TestosteroneCytochrome P450 3A7enzyme
DB00624TestosteroneSolute carrier organic anion transporter family member 1A2transporter
DB00624TestosteroneSolute carrier family 22 member 8transporter
DB00624TestosteroneSolute carrier family 22 member 7transporter
DB00624TestosteroneSolute carrier family 22 member 1transporter
DB00624TestosteroneMultidrug resistance protein 1transporter
DB00624TestosteroneSodium/bile acid cotransportertransporter
DB00624TestosteroneSolute carrier family 22 member 3transporter
DB00624TestosteroneSolute carrier family 22 member 4transporter
DB00624TestosteroneATP-binding cassette sub-family G member 2transporter
DB00624TestosteroneCytochrome P450 1A1enzyme
DB00624TestosteroneCytochrome P450 1B1enzyme
DB00624TestosteroneCytochrome P450 2A13enzyme
DB00624TestosteroneCytochrome P450 2B6enzyme
DB00624TestosteroneCytochrome P450 2C19enzyme
DB00624TestosteroneCytochrome P450 2C8enzyme
DB00624TestosteroneCytochrome P450 2C9enzyme
DB00624TestosteroneCytochrome P450 3A43enzyme
DB00624TestosteroneEstrogen receptor alphatarget
DB00624TestosteroneMineralocorticoid receptortarget
DB00717NorethisteroneProgesterone receptortarget
DB00717NorethisteroneCytochrome P450 3A4enzyme
DB00717NorethisteroneMultidrug resistance protein 1transporter
DB00717NorethisteroneCytochrome P450 2C19enzyme
DB00717NorethisteroneCytochrome P450 3A5enzyme
DB00717NorethisteroneCytochrome P450 3A7enzyme
DB00717NorethisteroneSerum albumincarrier
DB00717NorethisteroneSex hormone-binding globulincarrier
DB00984Nandrolone phenpropionateAndrogen receptortarget
DB00984Nandrolone phenpropionateCytochrome P450 19A1enzyme
DB01108Trilostane3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
DB01108Trilostane3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2target
DB01108TrilostaneEstrogen receptor betatarget
DB01108TrilostaneEstrogen receptor alphatarget
DB01420Testosterone PropionateAndrogen receptortarget
DB01420Testosterone PropionateCatechol O-methyltransferaseenzyme
DB01420Testosterone PropionateUDP-glucuronosyltransferase 1-1enzyme
DB01481Delta1-dihydrotestosteroneAndrogen receptortarget
DB01536AndrostenedioneAldo-keto reductase family 1 member C3target
DB01536AndrostenedioneEstradiol 17-beta-dehydrogenase 1target
DB01536Androstenedione6-deoxyerythronolide B hydroxylasetarget
DB01536Androstenedione3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
DB01541BoldenoneAndrogen receptortarget
DB01564CalusteroneAndrogen receptortarget
DB01708PrasteroneSteroid Delta-isomerasetarget
DB01708PrasteroneBile salt sulfotransferasetarget
DB01708PrasteroneCholesterol oxidasetarget
DB01708PrasteroneEstradiol 17-beta-dehydrogenase 1target
DB01708PrasteroneSulfotransferase family cytosolic 2B member 1target
DB01708PrasteroneCytochrome P450 3A4enzyme
DB01708PrasteroneCytochrome P450 3A7enzyme
DB01708PrasteronePeroxisome proliferator-activated receptor alphatarget
DB01708PrasteroneEstrogen receptor alphatarget
DB01708PrasteroneSigma non-opioid intracellular receptor 1target
DB01708PrasteroneEstrogen receptor betatarget
DB01708PrasteroneNuclear receptor subfamily 1 group I member 2target
DB01708PrasteroneNuclear receptor subfamily 1 group I member 3target
DB01708PrasteroneGABA-A receptor (anion channel)target
DB01708PrasteroneNMDA receptortarget
DB01708PrasteroneAndrogen receptortarget
DB02901DihydrotestosteroneSex hormone-binding globulincarrier
DB02901DihydrotestosteroneAndrogen receptortarget
DB02901DihydrotestosteroneEstradiol 17-beta-dehydrogenase 1target
DB02901DihydrotestosteroneMultidrug resistance protein 1transporter
DB02901DihydrotestosteroneCholesterol side-chain cleavage enzyme, mitochondrialenzyme
DB02901DihydrotestosteroneSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
DB02901DihydrotestosteroneCytochrome P450 19A1enzyme
DB02901DihydrotestosteroneEstrogen receptor alphatarget
DB02901DihydrotestosteroneMineralocorticoid receptortarget
DB04468AfimoxifeneEstrogen receptor alphatarget
DB04468AfimoxifeneEstrogen receptor betatarget
DB04468AfimoxifeneEstrogen-related receptor gammatarget
DB04468AfimoxifeneTrefoil factor 1target
DB04468AfimoxifeneSteroid hormone receptor ERR1target
DB04468AfimoxifeneNuclear receptor subfamily 1 group I member 2target
DB04468AfimoxifeneSex hormone-binding globulintarget
DB0510716-BromoepiandrosteroneGlucose-6-phosphate 1-dehydrogenasetarget
DB05212HE3286Nuclear factor NF-kappa-B p105 subunittarget
DB05212HE3286Nuclear factor NF-kappa-B p100 subunittarget
DB05804Prasterone sulfateCytochrome P450 19A1enzyme
DB05804Prasterone sulfateCytochrome P450 3A7enzyme
DB05804Prasterone sulfateProstaglandin G/H synthase 2enzyme
DB05804Prasterone sulfateSolute carrier family 22 member 8transporter
DB05804Prasterone sulfateSolute carrier organic anion transporter family member 1A2transporter
DB05804Prasterone sulfateSolute carrier organic anion transporter family member 1B1transporter
DB05804Prasterone sulfateSolute carrier organic anion transporter family member 1B3transporter
DB05804Prasterone sulfateSolute carrier organic anion transporter family member 2B1transporter
DB05804Prasterone sulfateSolute carrier family 10 member 6transporter
DB06710MethyltestosteroneCytochrome P450 19A1enzyme
DB06710MethyltestosteroneCytochrome P450 2B6enzyme
DB06710MethyltestosteroneCytochrome P450 3A4enzyme
DB06710MethyltestosteroneAndrogen receptortarget
DB06710MethyltestosteroneSolute carrier organic anion transporter family member 1A2transporter
DB06710MethyltestosteroneSolute carrier family 22 member 8transporter
DB06710MethyltestosteroneSerum albumincarrier
DB06710MethyltestosteroneSex hormone-binding globulincarrier
DB06710MethyltestosteroneEstrogen receptor alphatarget
DB08619TESTOSTERONE HEMISUCCINATENeocarzinostatintarget
DB08804Nandrolone decanoateAndrogen receptortarget
DB08804Nandrolone decanoateCytochrome P450 19A1enzyme
DB08804Nandrolone decanoateAmine oxidase [flavin-containing] Benzyme
DB08804Nandrolone decanoateAmine oxidase [flavin-containing] Aenzyme
DB09123DienogestCytochrome P450 3A4enzyme
DB09123DienogestProgesterone receptortarget
DB09123DienogestAndrogen receptortarget