Testosterone Congeners

Name
Testosterone Congeners
Accession Number
DBCAT001014  (DBCAT001357, DBCAT003190)
Description

Steroidal compounds related to TESTOSTERONE, the major mammalian male sex hormone. Testosterone congeners include important testosterone precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with androgenic activities.

ATC Classification
Drugs
DrugDrug Description
TestosteroneA hormone used to treat hypogonadism, breast carcinoma in women, or the vasomotor symptoms of menopause.
Nandrolone phenpropionateFor the treatment of refractory deficient red cell production anemias, breast carcinoma, hereditary angioedema, antithrombin III deficiency, fibrinogen excess, growth failure and Turner's syndrome. It is also indicated in the...
TrilostaneUsed in the treatment of Cushing's syndrome. It is normally used in short-term treatment until permanent therapy is possible.
Testosterone propionateA slow-release anabolic steroid no longer used commonly for the treatment of androgen deficiency or promotion of anabolic effects on muscles.
19-norandrostenedioneThe claim that supplemental 19-norandrostenedione has anabolic effects is unsubstantiated.
5-androstenedione5-androstenedione is a prohormone of testosterone. In the United States, the Controlled Substance Act is inclusive to anabolic steroids and their precursors. Thus 5-androstenedione is a controlled substance, and its...
BolasteroneNot Available
1-Testosterone1-Testosterone is an anabolic steroid that differs from testosterone by having a 1,2-double bond instead of 4,5-double bond in its A ring.
4-Hydroxytestosterone4-Hydroxytestosterone is testosterone substituted with a hydroxy group on the fourth carbon atom. It is an anabolic steroid with no therapeutic indications, which is prohibited from use in sports by...
ClostebolNot Available
AndrostenediolAndrostenediol is an intermediate in testosterone biosynthesis, found in the testis or the adrenal glands. Androstenediol, derived from dehydroepiandrosterone by the reduction of the 17-keto group (17-hydroxysteroid dehydrogenases), is converted...
AndrostenedioneA delta-4 C19 steroid that is produced not only in the testis, but also in the ovary and the adrenal cortex. Depending on the tissue type, androstenedione can serve as...
BoldenoneBoldenone is an anabolic steroid developed for veterinary use, mostly for treatment of horses. It is not indicated for use in humans in the US and is only available through...
BolandiolNot Available
CalusteroneAn anabolic steroid which can theoretically aid in restauration and buildup of certain tissues, especially muscle. It is similar to synthetic testosterone and is still in early investigation. It was...
PrasteroneA steroid formulated as a vaginal insert indicated for the treatment of moderate to severe dyspareunia associated with menopausal vulvar and vaginal atrophy.
StanoloneA potent androgenic metabolite of testosterone. Dihydrotestosterone (DHT) is generated by a 5-alpha reduction of testosterone. Unlike testosterone, DHT cannot be aromatized to estradiol therefore DHT is considered a pure...
16-BromoepiandrosteroneInvestigated for use/treatment in cystic fibrosis, HIV infection, hepatitis (viral, B), and malaria.
Prasterone sulfateInvestigated for use/treatment in asthma and burns and burn infections.
TrestoloneInvestigated for use/treatment in contraception and male hormonal deficiencies/abnormalities.
FluasteroneInvestigated for use/treatment in psoriasis and psoriatic disorders, hyperlipidemia, metabolic disease, cancer/tumors (unspecified), and obesity.
MethyltestosteroneA synthetic anabolic steroid used for the replacement therapy in conditions associated with testosterone deficiencies in males, such as hypogonadism, and treatment of advancing inoperable metastatic breast cancer in females.
Testosterone succinateNot Available
Nandrolone decanoateAn anabolic steroid indicated for the management of the anemia of renal insufficiency by increasing hemoglobin and red cell mass.
FormestaneFor the treatment of estrogen-receptor positive breast cancer in post-menopausal women.
DienogestAn oral progestin used for the treatment of endometriosis as monotherapy or contraception in combination with ethinylestradiol.
MiboleroneMibolerone is a potent anabolic steroid which is both higher affinity and more selective for the androgen receptor than metribolone.
AtamestaneAtamestane has been used in trials studying the treatment of Breast Cancer, Breast Neoplasms, and Neoplasms, Hormone-Dependent.
NandroloneNandrolone, also known as 19-nortestosterone or 19-norandrostenolone, is a synthetic anabolic-androgenic steroid (AAS) derived from testosterone.
MesteroloneMesterolone is a synthetic anabolic-androgenic steroid (AAS) and derivative of dihydrotestosterone (DHT). It is inactivated by 3α-hydroxysteroid dehydrogenase in skeleta muscules so it is considered a weak androgen. It is...
MetenoloneNot Annotated
Testosterone cypionateAn androgen used to treat low or absent testosterone.
Testosterone enanthateAn androgen used to treat low or absent testosterone.
Testosterone undecanoateAn androgen used to treat low or absent testosterone.
Testosterone enantate benzilic acid hydrazoneNot Annotated
Trestolone acetateTrestolone acetate is a synthetic and injected anabolic–androgenic steroid (AAS) and a derivative of nandrolone (19-nortestosterone) which was never marketed. It is an androgen ester – specifically, the C17 acetate...
EpitestosteroneEpitestosterone is the 17-alpha isomer of testosterone, derived from pregnenolone via the delta5-steroid pathway, and via 5-androstene-3-beta,17-alpha-diol. Epitestosterone acts as an antiandrogen in various target tissues. The ratio between testosterone/epitestosterone...
Drugs & Drug Targets
DrugTargetType
TestosteroneAndrogen receptortarget
TestosteroneCytochrome P450 3A4enzyme
TestosteroneCytochrome P450 19A1enzyme
TestosteroneAmine oxidase [flavin-containing] Aenzyme
TestosteroneCholesterol side-chain cleavage enzyme, mitochondrialenzyme
TestosteroneSerum albumincarrier
TestosteroneSex hormone-binding globulincarrier
TestosteroneCytochrome P450 3A5enzyme
TestosteroneCytochrome P450 3A7enzyme
TestosteroneSolute carrier family 22 member 8transporter
TestosteroneSolute carrier family 22 member 7transporter
TestosteroneSodium/bile acid cotransportertransporter
TestosteroneATP-binding cassette sub-family G member 2transporter
TestosteroneCytochrome P450 1A1enzyme
TestosteroneCytochrome P450 1B1enzyme
TestosteroneCytochrome P450 2A13enzyme
TestosteroneCytochrome P450 2B6enzyme
TestosteroneCytochrome P450 2C19enzyme
TestosteroneCytochrome P450 2C8enzyme
TestosteroneCytochrome P450 2C9enzyme
TestosteroneCytochrome P450 3A43enzyme
TestosteroneEstrogen receptor alphatarget
TestosteroneMineralocorticoid receptortarget
TestosteroneSolute carrier organic anion transporter family member 1B3transporter
Nandrolone phenpropionateAndrogen receptortarget
Trilostane3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
Trilostane3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2target
TrilostaneEstrogen receptor betatarget
TrilostaneEstrogen receptor alphatarget
TrilostaneCytochrome P450 3A4enzyme
Testosterone propionateAndrogen receptortarget
Testosterone propionateCatechol O-methyltransferaseenzyme
Testosterone propionateUDP-glucuronosyltransferase 1-1enzyme
Testosterone propionate3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme
Testosterone propionateCytochrome P450 3A4enzyme
Testosterone propionateP-glycoprotein 1transporter
Testosterone propionateSex hormone-binding globulincarrier
Testosterone propionateSerum albumincarrier
5-androstenedioneCytochrome P450 3A4enzyme
1-TestosteroneAndrogen receptortarget
AndrostenedioneAldo-keto reductase family 1 member C3target
AndrostenedioneEstradiol 17-beta-dehydrogenase 1target
Androstenedione6-deoxyerythronolide B hydroxylasetarget
Androstenedione3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
AndrostenedioneCytochrome P450 3A4enzyme
BoldenoneAndrogen receptortarget
CalusteroneAndrogen receptortarget
PrasteroneCytochrome P450 3A7enzyme
PrasteronePeroxisome proliferator-activated receptor alphatarget
PrasteroneEstrogen receptor alphatarget
PrasteroneSigma non-opioid intracellular receptor 1target
PrasteroneEstrogen receptor betatarget
PrasteroneNuclear receptor subfamily 1 group I member 2target
PrasteroneNuclear receptor subfamily 1 group I member 3target
PrasteroneGABA(A) Receptortarget
PrasteroneNMDA receptortarget
PrasteroneAndrogen receptortarget
PrasteroneEstradiol 17-beta-dehydrogenase 1enzyme
PrasteroneBile salt sulfotransferaseenzyme
PrasteroneSulfotransferase family cytosolic 2B member 1enzyme
Prasterone3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1enzyme
PrasteroneCholesterol oxidaseenzyme
PrasteroneSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
PrasteroneSolute carrier organic anion transporter family member 1B3transporter
PrasteroneSolute carrier organic anion transporter family member 2B1transporter
PrasteroneSolute carrier organic anion transporter family member 1B1transporter
PrasteroneSolute carrier organic anion transporter family member 1A2transporter
PrasteroneMultidrug resistance-associated protein 1transporter
PrasteroneATP-binding cassette sub-family G member 2transporter
PrasteroneMultidrug resistance-associated protein 4transporter
StanoloneSex hormone-binding globulincarrier
StanoloneAndrogen receptortarget
StanoloneEstradiol 17-beta-dehydrogenase 1target
StanoloneP-glycoprotein 1transporter
StanoloneCholesterol side-chain cleavage enzyme, mitochondrialenzyme
StanoloneSteroid 17-alpha-hydroxylase/17,20 lyaseenzyme
StanoloneCytochrome P450 19A1enzyme
StanoloneEstrogen receptor alphatarget
StanoloneMineralocorticoid receptortarget
16-BromoepiandrosteroneGlucose-6-phosphate 1-dehydrogenasetarget
Prasterone sulfateCytochrome P450 19A1enzyme
Prasterone sulfateCytochrome P450 3A7enzyme
Prasterone sulfateProstaglandin G/H synthase 2enzyme
Prasterone sulfateSolute carrier family 22 member 8transporter
Prasterone sulfateSolute carrier organic anion transporter family member 1A2transporter
Prasterone sulfateSolute carrier organic anion transporter family member 1B1transporter
Prasterone sulfateSolute carrier organic anion transporter family member 1B3transporter
Prasterone sulfateSolute carrier organic anion transporter family member 2B1transporter
Prasterone sulfateSolute carrier family 10 member 6transporter
Prasterone sulfateBile salt export pumptransporter
MethyltestosteroneCytochrome P450 2B6enzyme
MethyltestosteroneCytochrome P450 3A4enzyme
MethyltestosteroneAndrogen receptortarget
MethyltestosteroneSolute carrier organic anion transporter family member 1A2transporter
MethyltestosteroneSolute carrier family 22 member 8transporter
MethyltestosteroneSerum albumincarrier
MethyltestosteroneSex hormone-binding globulincarrier
MethyltestosteroneEstrogen receptor alphatarget
MethyltestosteroneCytochrome P450 19A1enzyme
Testosterone succinateNeocarzinostatintarget
Nandrolone decanoateAndrogen receptortarget
Nandrolone decanoateCytochrome P450 19A1enzyme
Nandrolone decanoateAmine oxidase [flavin-containing] Benzyme
Nandrolone decanoateAmine oxidase [flavin-containing] Aenzyme
FormestaneCytochrome P450 3A4enzyme
DienogestCytochrome P450 3A4enzyme
DienogestProgesterone receptortarget
DienogestAndrogen receptortarget
MiboleroneAndrogen receptortarget
Testosterone cypionateAndrogen receptortarget
Testosterone cypionateCytochrome P450 3A4enzyme
Testosterone cypionateAmine oxidase [flavin-containing] Aenzyme
Testosterone cypionateCholesterol side-chain cleavage enzyme, mitochondrialenzyme
Testosterone cypionateSerum albumincarrier
Testosterone cypionateSex hormone-binding globulincarrier
Testosterone cypionateCytochrome P450 3A5enzyme
Testosterone cypionateCytochrome P450 3A7enzyme
Testosterone cypionateSolute carrier organic anion transporter family member 1A2transporter
Testosterone cypionateSolute carrier family 22 member 8transporter
Testosterone cypionateSolute carrier family 22 member 7transporter
Testosterone cypionateP-glycoprotein 1transporter
Testosterone cypionateSodium/bile acid cotransportertransporter
Testosterone cypionateSolute carrier family 22 member 3transporter
Testosterone cypionateSolute carrier family 22 member 4transporter
Testosterone cypionateATP-binding cassette sub-family G member 2transporter
Testosterone cypionateCytochrome P450 1A1enzyme
Testosterone cypionateCytochrome P450 2A13enzyme
Testosterone cypionateCytochrome P450 2B6enzyme
Testosterone cypionateCytochrome P450 2C19enzyme
Testosterone cypionateCytochrome P450 2C8enzyme
Testosterone cypionateCytochrome P450 2C9enzyme
Testosterone cypionateCytochrome P450 3A43enzyme
Testosterone cypionateEstrogen receptor alphatarget
Testosterone cypionateMineralocorticoid receptortarget
Testosterone cypionate3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme
Testosterone cypionateCytochrome P450 19A1enzyme
Testosterone enanthateAndrogen receptortarget
Testosterone enanthateCytochrome P450 3A4enzyme
Testosterone enanthateAmine oxidase [flavin-containing] Aenzyme
Testosterone enanthateCholesterol side-chain cleavage enzyme, mitochondrialenzyme
Testosterone enanthateSerum albumincarrier
Testosterone enanthateSex hormone-binding globulincarrier
Testosterone enanthateCytochrome P450 3A5enzyme
Testosterone enanthateCytochrome P450 3A7enzyme
Testosterone enanthateSolute carrier organic anion transporter family member 1A2transporter
Testosterone enanthateSolute carrier family 22 member 8transporter
Testosterone enanthateSolute carrier family 22 member 7transporter
Testosterone enanthateP-glycoprotein 1transporter
Testosterone enanthateSodium/bile acid cotransportertransporter
Testosterone enanthateSolute carrier family 22 member 3transporter
Testosterone enanthateSolute carrier family 22 member 4transporter
Testosterone enanthateATP-binding cassette sub-family G member 2transporter
Testosterone enanthateCytochrome P450 1A1enzyme
Testosterone enanthateCytochrome P450 2A13enzyme
Testosterone enanthateCytochrome P450 2B6enzyme
Testosterone enanthateCytochrome P450 2C19enzyme
Testosterone enanthateCytochrome P450 2C8enzyme
Testosterone enanthateCytochrome P450 2C9enzyme
Testosterone enanthateCytochrome P450 3A43enzyme
Testosterone enanthateEstrogen receptor alphatarget
Testosterone enanthateMineralocorticoid receptortarget
Testosterone enanthate3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme
Testosterone enanthateCytochrome P450 19A1enzyme
Testosterone undecanoateAndrogen receptortarget
Testosterone undecanoateCytochrome P450 3A4enzyme
Testosterone undecanoateAmine oxidase [flavin-containing] Aenzyme
Testosterone undecanoateCholesterol side-chain cleavage enzyme, mitochondrialenzyme
Testosterone undecanoateSerum albumincarrier
Testosterone undecanoateSex hormone-binding globulincarrier
Testosterone undecanoateCytochrome P450 3A5enzyme
Testosterone undecanoateCytochrome P450 3A7enzyme
Testosterone undecanoateSolute carrier organic anion transporter family member 1A2transporter
Testosterone undecanoateSolute carrier family 22 member 8transporter
Testosterone undecanoateSolute carrier family 22 member 7transporter
Testosterone undecanoateP-glycoprotein 1transporter
Testosterone undecanoateSodium/bile acid cotransportertransporter
Testosterone undecanoateSolute carrier family 22 member 4transporter
Testosterone undecanoateATP-binding cassette sub-family G member 2transporter
Testosterone undecanoateCytochrome P450 1A1enzyme
Testosterone undecanoateCytochrome P450 1B1enzyme
Testosterone undecanoateCytochrome P450 2A13enzyme
Testosterone undecanoateCytochrome P450 2B6enzyme
Testosterone undecanoateCytochrome P450 2C19enzyme
Testosterone undecanoateCytochrome P450 2C8enzyme
Testosterone undecanoateCytochrome P450 2C9enzyme
Testosterone undecanoateCytochrome P450 3A43enzyme
Testosterone undecanoateEstrogen receptor alphatarget
Testosterone undecanoateMineralocorticoid receptortarget
Testosterone undecanoate3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme
Testosterone undecanoateSolute carrier family 22 member 2transporter
Testosterone undecanoateMultidrug and toxin extrusion protein 1transporter
Testosterone undecanoateSolute carrier organic anion transporter family member 1B3transporter
Testosterone undecanoateCytochrome P450 19A1enzyme
EpitestosteroneAldo-keto reductase family 1 member C1target
EpitestosteroneAldo-keto reductase family 1 member C2target