Afelimomab

Identification

Name
Afelimomab
Accession Number
DB04956
Type
Biotech
Groups
Investigational
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Description

Afelimomab (also known as Fab 2 or MAK 195F) is an anti-TNF-α monoclonal antibody. Administration of 195F reduces the concentration of interleukin-6 in patients with sepsis.

Protein structure
Db04956
Protein chemical formula
Not Available
Protein average weight
Not Available
Sequences
Not Available
Synonyms
  • Fab 2
  • MAK 195F
International/Other Brands
Segard
Categories
UNII
6SC756X51V
CAS number
156227-98-4

Pharmacology

Indication

Investigated for use/treatment in sepsis and septicemia.

Pharmacodynamics

Afelimomab is the F(ab')2 fragment of a murine anti-TNF-alpha antibody, and has been evaluated in clinical trials in septic patients. The results suggest that the drug is well tolerated, and may be of benefit in certain groups of patients with sepsis. Afelimomab is safe, biologically active, and well tolerated in patients with severe sepsis, reduces 28-day all-cause mortality, and attenuates the severity of organ dysfunction in patients with elevated interleukin-6 levels.

Mechanism of action
TargetActionsOrganism
UTumor necrosis factorNot AvailableHuman
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life

44.7 hours

Clearance
Not Available
Toxicity
Not Available
Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
AbataceptThe risk or severity of infection can be increased when Afelimomab is combined with Abatacept.
AbciximabThe risk or severity of adverse effects can be increased when Abciximab is combined with Afelimomab.
AdalimumabThe risk or severity of adverse effects can be increased when Adalimumab is combined with Afelimomab.
AlclometasoneThe risk or severity of adverse effects can be increased when Afelimomab is combined with Alclometasone.
AldesleukinThe risk or severity of adverse effects can be increased when Afelimomab is combined with Aldesleukin.
AlemtuzumabThe risk or severity of adverse effects can be increased when Alemtuzumab is combined with Afelimomab.
AmcinonideThe risk or severity of adverse effects can be increased when Afelimomab is combined with Amcinonide.
AmsacrineThe risk or severity of adverse effects can be increased when Amsacrine is combined with Afelimomab.
AnakinraThe risk or severity of adverse effects can be increased when Afelimomab is combined with Anakinra.
Anthrax immune globulin humanThe risk or severity of adverse effects can be increased when Afelimomab is combined with Anthrax immune globulin human.
Food Interactions
Not Available

References

General References
  1. Vincent JL: Afelimomab. Int J Clin Pract. 2000 Apr;54(3):190-3. [PubMed:10829362]
  2. Gallagher J, Fisher C, Sherman B, Munger M, Meyers B, Ellison T, Fischkoff S, Barchuk WT, Teoh L, Velagapudi R: A multicenter, open-label, prospective, randomized, dose-ranging pharmacokinetic study of the anti-TNF-alpha antibody afelimomab in patients with sepsis syndrome. Intensive Care Med. 2001 Jul;27(7):1169-78. [PubMed:11534565]
External Links
PubChem Substance
347909858
Wikipedia
Afelimomab
ATC Codes
L04AB03 — Afelimomab

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available

Taxonomy

Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available

Targets

Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Tumor necrosis factor receptor binding
Specific Function
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct ac...
Gene Name
TNF
Uniprot ID
P01375
Uniprot Name
Tumor necrosis factor
Molecular Weight
25644.15 Da
References
  1. Vincent JL: Afelimomab. Int J Clin Pract. 2000 Apr;54(3):190-3. [PubMed:10829362]

Drug created on October 21, 2007 16:23 / Updated on August 02, 2018 05:28