Etifoxine

Identification

Name
Etifoxine
Accession Number
DB08986
Type
Small Molecule
Groups
Withdrawn
Description

Etifoxine is an anxiolytic and anticonvulsant drug developed by Hoechst in the 1960s. It is used in anxiety disorders and to promote peripheral nerve healing. It has similar effects to benzodiazepine drugs, but is structurally distinct and does not bind to the benzodiazepine receptor. It is more effective than lorazepam as an anxiolytic, and has fewer side effects. Etifoxine has been associated with acute liver injury.

Structure
Thumb
Synonyms
Not Available
Product Ingredients
IngredientUNIICASInChI Key
Etifoxine hydrochlorideNBL8010WH556776-32-0SCBJXEBIMVRTJE-UHFFFAOYSA-N
International/Other Brands
Exsist (Euroetika) / Stresam (Biocodex)
Categories
UNII
X24X82MX4X
CAS number
21715-46-8
Weight
Average: 300.79
Monoisotopic: 300.1029409
Chemical Formula
C17H17ClN2O
InChI Key
IBYCYJFUEJQSMK-UHFFFAOYSA-N
InChI
InChI=1S/C17H17ClN2O/c1-3-19-16-20-15-10-9-13(18)11-14(15)17(2,21-16)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3,(H,19,20)
IUPAC Name
6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine
SMILES
CCNC1=NC2=CC=C(Cl)C=C2C(C)(O1)C1=CC=CC=C1

Pharmacology

Indication
Not Available
Structured Indications
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
7-NitroindazoleThe risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Etifoxine.Experimental
AcepromazineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Etifoxine.Approved, Vet Approved
AceprometazineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Etifoxine.Approved
AdipiplonThe risk or severity of adverse effects can be increased when Adipiplon is combined with Etifoxine.Investigational
AgomelatineThe risk or severity of adverse effects can be increased when Agomelatine is combined with Etifoxine.Approved, Investigational
AlaproclateThe risk or severity of adverse effects can be increased when Etifoxine is combined with Alaproclate.Experimental
AlfaxaloneThe risk or severity of adverse effects can be increased when Etifoxine is combined with Alfaxalone.Vet Approved
AlfentanilThe risk or severity of adverse effects can be increased when Alfentanil is combined with Etifoxine.Approved, Illicit
AllopregnanoloneThe risk or severity of adverse effects can be increased when Etifoxine is combined with Allopregnanolone.Investigational
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Etifoxine.Experimental, Illicit
AlphaprodineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Alphaprodine.Illicit
AlprazolamThe risk or severity of adverse effects can be increased when Alprazolam is combined with Etifoxine.Approved, Illicit, Investigational
AmisulprideThe risk or severity of adverse effects can be increased when Amisulpride is combined with Etifoxine.Approved, Investigational
AmitriptylineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Amitriptyline.Approved
AmobarbitalThe risk or severity of adverse effects can be increased when Amobarbital is combined with Etifoxine.Approved, Illicit
AmoxapineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Amoxapine.Approved
AmperozideThe risk or severity of adverse effects can be increased when Amperozide is combined with Etifoxine.Experimental
AripiprazoleThe risk or severity of adverse effects can be increased when Aripiprazole is combined with Etifoxine.Approved, Investigational
ArticaineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Articaine.Approved
AsenapineThe risk or severity of adverse effects can be increased when Asenapine is combined with Etifoxine.Approved
AzaperoneThe risk or severity of adverse effects can be increased when Etifoxine is combined with Azaperone.Vet Approved
AzelastineEtifoxine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.Approved
BaclofenThe risk or severity of adverse effects can be increased when Etifoxine is combined with Baclofen.Approved
BarbitalThe risk or severity of adverse effects can be increased when Barbital is combined with Etifoxine.Illicit
BenperidolThe risk or severity of adverse effects can be increased when Etifoxine is combined with Benperidol.Investigational
BenzocaineThe risk or severity of adverse effects can be increased when Benzocaine is combined with Etifoxine.Approved
Benzyl alcoholThe risk or severity of adverse effects can be increased when Benzyl alcohol is combined with Etifoxine.Approved
BrexpiprazoleThe risk or severity of adverse effects can be increased when Etifoxine is combined with Brexpiprazole.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Etifoxine.Approved
BromazepamThe risk or severity of adverse effects can be increased when Bromazepam is combined with Etifoxine.Approved, Illicit
BromisovalThe risk or severity of adverse effects can be increased when Etifoxine is combined with Bromisoval.Experimental
BromperidolThe risk or severity of adverse effects can be increased when Etifoxine is combined with Bromperidol.Investigational
BrompheniramineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Brompheniramine.Approved
BrotizolamThe risk or severity of adverse effects can be increased when Etifoxine is combined with Brotizolam.Approved, Withdrawn
BupivacaineThe risk or severity of adverse effects can be increased when Bupivacaine is combined with Etifoxine.Approved, Investigational
BuprenorphineEtifoxine may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Etifoxine.Approved, Investigational
ButabarbitalThe risk or severity of adverse effects can be increased when Butabarbital is combined with Etifoxine.Approved, Illicit
ButacaineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Butacaine.Vet Approved
ButalbitalThe risk or severity of adverse effects can be increased when Etifoxine is combined with Butalbital.Approved, Illicit
ButambenThe risk or severity of adverse effects can be increased when Etifoxine is combined with Butamben.Approved
ButethalThe risk or severity of adverse effects can be increased when Butethal is combined with Etifoxine.Approved, Illicit
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Etifoxine.Approved, Illicit, Vet Approved
CanertinibThe risk or severity of adverse effects can be increased when Canertinib is combined with Etifoxine.Investigational
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Etifoxine.Approved, Investigational
CarbinoxamineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Carbinoxamine.Approved
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Etifoxine.Illicit, Vet Approved
CarisoprodolThe risk or severity of adverse effects can be increased when Etifoxine is combined with Carisoprodol.Approved
CetirizineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Cetirizine.Approved
Chloral hydrateThe risk or severity of adverse effects can be increased when Chloral hydrate is combined with Etifoxine.Approved, Illicit, Vet Approved
ChlordiazepoxideThe risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Etifoxine.Approved, Illicit
ChlormezanoneThe risk or severity of adverse effects can be increased when Chlormezanone is combined with Etifoxine.Approved, Withdrawn
ChloroprocaineThe risk or severity of adverse effects can be increased when Chloroprocaine is combined with Etifoxine.Approved
ChlorphenamineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Chlorphenamine.Approved
ChlorpromazineThe risk or severity of adverse effects can be increased when Chlorpromazine is combined with Etifoxine.Approved, Vet Approved
ChlorprothixeneThe risk or severity of adverse effects can be increased when Chlorprothixene is combined with Etifoxine.Approved, Withdrawn
ChlorzoxazoneThe risk or severity of adverse effects can be increased when Etifoxine is combined with Chlorzoxazone.Approved
CinchocaineThe risk or severity of adverse effects can be increased when Cinchocaine is combined with Etifoxine.Approved, Vet Approved
CitalopramThe risk or severity of adverse effects can be increased when Etifoxine is combined with Citalopram.Approved
ClemastineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Clemastine.Approved
ClidiniumThe risk or severity of adverse effects can be increased when Etifoxine is combined with Clidinium.Approved
ClobazamThe risk or severity of adverse effects can be increased when Etifoxine is combined with Clobazam.Approved, Illicit
clomethiazoleThe risk or severity of adverse effects can be increased when clomethiazole is combined with Etifoxine.Investigational
ClomipramineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Clomipramine.Approved, Vet Approved
ClonazepamThe risk or severity of adverse effects can be increased when Etifoxine is combined with Clonazepam.Approved, Illicit
ClonidineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Clonidine.Approved
ClopenthixolThe risk or severity of adverse effects can be increased when Etifoxine is combined with Clopenthixol.Experimental
ClorazepateThe risk or severity of adverse effects can be increased when Clorazepate is combined with Etifoxine.Approved, Illicit
ClothiapineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Clothiapine.Experimental
ClozapineThe risk or severity of adverse effects can be increased when Clozapine is combined with Etifoxine.Approved
CocaineThe risk or severity of adverse effects can be increased when Cocaine is combined with Etifoxine.Approved, Illicit
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Etifoxine.Approved, Illicit
CyclizineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Cyclizine.Approved
CyclobenzaprineThe risk or severity of adverse effects can be increased when Cyclobenzaprine is combined with Etifoxine.Approved
CyproheptadineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Cyproheptadine.Approved
DantroleneThe risk or severity of adverse effects can be increased when Etifoxine is combined with Dantrolene.Approved
DapiprazoleThe risk or severity of adverse effects can be increased when Dapiprazole is combined with Etifoxine.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Dapoxetine.Investigational
DeramciclaneThe risk or severity of adverse effects can be increased when Deramciclane is combined with Etifoxine.Investigational
DesfluraneThe risk or severity of adverse effects can be increased when Desflurane is combined with Etifoxine.Approved
DesipramineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Desipramine.Approved
DesloratadineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Desloratadine.Approved, Investigational
DesvenlafaxineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Desvenlafaxine.Approved
DetomidineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Detomidine.Vet Approved
DexbrompheniramineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Dexbrompheniramine.Approved
DexmedetomidineThe risk or severity of adverse effects can be increased when Dexmedetomidine is combined with Etifoxine.Approved, Vet Approved
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Etifoxine.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Etifoxine.Approved, Illicit, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Etifoxine.Approved
DiazepamThe risk or severity of adverse effects can be increased when Diazepam is combined with Etifoxine.Approved, Illicit, Vet Approved
Diethyl etherThe risk or severity of adverse effects can be increased when Etifoxine is combined with Diethyl ether.Experimental
DifenoxinThe risk or severity of adverse effects can be increased when Etifoxine is combined with Difenoxin.Approved, Illicit
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Etifoxine.Approved, Illicit
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Etifoxine.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Etifoxine.Experimental, Illicit
DimenhydrinateThe risk or severity of adverse effects can be increased when Etifoxine is combined with Dimenhydrinate.Approved
DiphenhydramineThe risk or severity of adverse effects can be increased when Diphenhydramine is combined with Etifoxine.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Etifoxine.Approved, Illicit
DixyrazineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Dixyrazine.Experimental
DoramectinThe risk or severity of adverse effects can be increased when Etifoxine is combined with Doramectin.Vet Approved
DoxepinThe risk or severity of adverse effects can be increased when Etifoxine is combined with Doxepin.Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Etifoxine.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when DPDPE is combined with Etifoxine.Investigational
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Etifoxine.Approved, Illicit
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Etifoxine.Approved, Vet Approved
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Etifoxine.Experimental, Illicit
DuloxetineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Duloxetine.Approved
DyclonineThe risk or severity of adverse effects can be increased when Dyclonine is combined with Etifoxine.Approved
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Etifoxine.Experimental, Illicit
EcopipamThe risk or severity of adverse effects can be increased when Etifoxine is combined with Ecopipam.Investigational
EfavirenzThe risk or severity of adverse effects can be increased when Etifoxine is combined with Efavirenz.Approved, Investigational
EltanoloneThe risk or severity of adverse effects can be increased when Etifoxine is combined with Eltanolone.Investigational
EnfluraneThe risk or severity of adverse effects can be increased when Enflurane is combined with Etifoxine.Approved, Vet Approved
EntacaponeThe risk or severity of adverse effects can be increased when Etifoxine is combined with Entacapone.Approved, Investigational
EscitalopramThe risk or severity of adverse effects can be increased when Etifoxine is combined with Escitalopram.Approved, Investigational
EstazolamThe risk or severity of adverse effects can be increased when Estazolam is combined with Etifoxine.Approved, Illicit
EszopicloneThe risk or severity of adverse effects can be increased when Eszopiclone is combined with Etifoxine.Approved
EthanolEtifoxine may increase the central nervous system depressant (CNS depressant) activities of Ethanol.Approved
EthchlorvynolThe risk or severity of adverse effects can be increased when Ethchlorvynol is combined with Etifoxine.Approved, Illicit, Withdrawn
EthosuximideThe risk or severity of adverse effects can be increased when Etifoxine is combined with Ethosuximide.Approved
EthotoinThe risk or severity of adverse effects can be increased when Etifoxine is combined with Ethotoin.Approved
Ethyl carbamateThe risk or severity of adverse effects can be increased when Ethyl carbamate is combined with Etifoxine.Withdrawn
Ethyl chlorideThe risk or severity of adverse effects can be increased when Etifoxine is combined with Ethyl chloride.Experimental
Ethyl loflazepateThe risk or severity of adverse effects can be increased when Ethyl loflazepate is combined with Etifoxine.Approved, Illicit
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Etifoxine.Approved, Illicit
EtidocaineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Etidocaine.Approved
EtizolamThe risk or severity of adverse effects can be increased when Etifoxine is combined with Etizolam.Approved
EtomidateThe risk or severity of adverse effects can be increased when Etomidate is combined with Etifoxine.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when Etifoxine is combined with Etoperidone.Approved
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Etifoxine.Illicit, Vet Approved
EzogabineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Ezogabine.Approved
FelbamateThe risk or severity of adverse effects can be increased when Etifoxine is combined with Felbamate.Approved
FencamfamineThe risk or severity of adverse effects can be increased when Fencamfamine is combined with Etifoxine.Approved, Illicit, Withdrawn
FentanylThe risk or severity of adverse effects can be increased when Fentanyl is combined with Etifoxine.Approved, Illicit, Investigational, Vet Approved
FexofenadineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Fexofenadine.Approved
FlibanserinThe risk or severity of adverse effects can be increased when Etifoxine is combined with Flibanserin.Approved
FluanisoneThe risk or severity of adverse effects can be increased when Etifoxine is combined with Fluanisone.Experimental
FludiazepamThe risk or severity of adverse effects can be increased when Fludiazepam is combined with Etifoxine.Approved, Illicit
FlunarizineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Flunarizine.Approved
FlunitrazepamThe risk or severity of adverse effects can be increased when Flunitrazepam is combined with Etifoxine.Approved, Illicit
FluoxetineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Fluoxetine.Approved, Vet Approved
FlupentixolThe risk or severity of adverse effects can be increased when Flupentixol is combined with Etifoxine.Approved, Withdrawn
FluphenazineThe risk or severity of adverse effects can be increased when Fluphenazine is combined with Etifoxine.Approved
FlurazepamThe risk or severity of adverse effects can be increased when Flurazepam is combined with Etifoxine.Approved, Illicit
FluspirileneThe risk or severity of adverse effects can be increased when Fluspirilene is combined with Etifoxine.Approved
Fluticasone propionateThe risk or severity of adverse effects can be increased when Etifoxine is combined with Fluticasone propionate.Approved
FluvoxamineThe risk or severity of adverse effects can be increased when Fluvoxamine is combined with Etifoxine.Approved, Investigational
FosphenytoinThe risk or severity of adverse effects can be increased when Etifoxine is combined with Fosphenytoin.Approved
FospropofolThe risk or severity of adverse effects can be increased when Fospropofol is combined with Etifoxine.Approved, Illicit
GabapentinThe risk or severity of adverse effects can be increased when Gabapentin is combined with Etifoxine.Approved, Investigational
Gabapentin EnacarbilThe risk or severity of adverse effects can be increased when Etifoxine is combined with Gabapentin Enacarbil.Approved
Gamma Hydroxybutyric AcidThe risk or severity of adverse effects can be increased when Gamma Hydroxybutyric Acid is combined with Etifoxine.Approved, Illicit
GepironeThe risk or severity of adverse effects can be increased when Etifoxine is combined with Gepirone.Investigational
GlutethimideThe risk or severity of adverse effects can be increased when Glutethimide is combined with Etifoxine.Approved, Illicit
GuanfacineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Guanfacine.Approved, Investigational
HalazepamThe risk or severity of adverse effects can be increased when Halazepam is combined with Etifoxine.Approved, Illicit, Withdrawn
HaloperidolThe risk or severity of adverse effects can be increased when Haloperidol is combined with Etifoxine.Approved
HalothaneThe risk or severity of adverse effects can be increased when Halothane is combined with Etifoxine.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Etifoxine.Approved, Illicit
HexobarbitalThe risk or severity of adverse effects can be increased when Hexobarbital is combined with Etifoxine.Approved
HydrocodoneEtifoxine may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydromorphoneThe risk or severity of adverse effects can be increased when Hydromorphone is combined with Etifoxine.Approved, Illicit
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Etifoxine.Approved
IloperidoneThe risk or severity of adverse effects can be increased when Etifoxine is combined with Iloperidone.Approved
ImipramineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Imipramine.Approved
IndalpineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Indalpine.Investigational, Withdrawn
IndiplonThe risk or severity of adverse effects can be increased when Etifoxine is combined with Indiplon.Investigational
IsofluraneThe risk or severity of adverse effects can be increased when Isoflurane is combined with Etifoxine.Approved, Vet Approved
KetamineThe risk or severity of adverse effects can be increased when Ketamine is combined with Etifoxine.Approved, Vet Approved
KetazolamThe risk or severity of adverse effects can be increased when Ketazolam is combined with Etifoxine.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Ketobemidone is combined with Etifoxine.Approved
LamotrigineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Lamotrigine.Approved, Investigational
LevetiracetamThe risk or severity of adverse effects can be increased when Etifoxine is combined with Levetiracetam.Approved, Investigational
LevobupivacaineThe risk or severity of adverse effects can be increased when Levobupivacaine is combined with Etifoxine.Approved
LevocabastineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Levocabastine.Approved
LevocetirizineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Levocetirizine.Approved
LevodopaThe risk or severity of adverse effects can be increased when Etifoxine is combined with Levodopa.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Etifoxine.Approved
LevomilnacipranThe risk or severity of adverse effects can be increased when Etifoxine is combined with Levomilnacipran.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Etifoxine.Approved
LidocaineThe risk or severity of adverse effects can be increased when Lidocaine is combined with Etifoxine.Approved, Vet Approved
LithiumThe risk or severity of adverse effects can be increased when Lithium is combined with Etifoxine.Approved
LofentanilThe risk or severity of adverse effects can be increased when Etifoxine is combined with Lofentanil.Illicit
LoprazolamThe risk or severity of adverse effects can be increased when Etifoxine is combined with Loprazolam.Experimental
LoratadineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Loratadine.Approved
LorazepamThe risk or severity of adverse effects can be increased when Lorazepam is combined with Etifoxine.Approved
LormetazepamThe risk or severity of adverse effects can be increased when Etifoxine is combined with Lormetazepam.Approved
LoxapineThe risk or severity of adverse effects can be increased when Loxapine is combined with Etifoxine.Approved
LurasidoneThe risk or severity of adverse effects can be increased when Lurasidone is combined with Etifoxine.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Etifoxine.Approved, Vet Approved
MaprotilineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Maprotiline.Approved
MebicarThe risk or severity of adverse effects can be increased when Etifoxine is combined with Mebicar.Experimental
MeclizineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Meclizine.Approved
MedazepamThe risk or severity of adverse effects can be increased when Etifoxine is combined with Medazepam.Experimental
MedetomidineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Medetomidine.Vet Approved
MelatoninThe risk or severity of adverse effects can be increased when Melatonin is combined with Etifoxine.Approved, Nutraceutical, Vet Approved
MelperoneThe risk or severity of adverse effects can be increased when Etifoxine is combined with Melperone.Approved
MepivacaineThe risk or severity of adverse effects can be increased when Mepivacaine is combined with Etifoxine.Approved, Vet Approved
MeprobamateThe risk or severity of adverse effects can be increased when Meprobamate is combined with Etifoxine.Approved, Illicit
MeptazinolThe risk or severity of adverse effects can be increased when Etifoxine is combined with Meptazinol.Experimental
MesoridazineThe risk or severity of adverse effects can be increased when Mesoridazine is combined with Etifoxine.Approved
MetaxaloneThe risk or severity of adverse effects can be increased when Etifoxine is combined with Metaxalone.Approved
MethadoneThe risk or severity of adverse effects can be increased when Methadone is combined with Etifoxine.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Etifoxine.Approved, Illicit
MethapyrileneThe risk or severity of adverse effects can be increased when Methapyrilene is combined with Etifoxine.Withdrawn
MethaqualoneThe risk or severity of adverse effects can be increased when Methaqualone is combined with Etifoxine.Illicit, Withdrawn
MethocarbamolThe risk or severity of adverse effects can be increased when Etifoxine is combined with Methocarbamol.Approved, Vet Approved
MethohexitalThe risk or severity of adverse effects can be increased when Methohexital is combined with Etifoxine.Approved
MethotrimeprazineEtifoxine may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneThe risk or severity of adverse effects can be increased when Methoxyflurane is combined with Etifoxine.Approved, Vet Approved
MethsuximideThe risk or severity of adverse effects can be increased when Etifoxine is combined with Methsuximide.Approved
MethylecgonineThe risk or severity of adverse effects can be increased when Methylecgonine is combined with Etifoxine.Experimental
MethylphenobarbitalThe risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Etifoxine.Approved
MetyrosineEtifoxine may increase the sedative activities of Metyrosine.Approved
MidazolamThe risk or severity of adverse effects can be increased when Midazolam is combined with Etifoxine.Approved, Illicit
MilnacipranThe risk or severity of adverse effects can be increased when Etifoxine is combined with Milnacipran.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Etifoxine.Approved, Investigational
MirtazapineEtifoxine may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MolindoneThe risk or severity of adverse effects can be increased when Molindone is combined with Etifoxine.Approved
MorphineThe risk or severity of adverse effects can be increased when Morphine is combined with Etifoxine.Approved, Investigational
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Etifoxine.Approved, Investigational
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Etifoxine.Approved
NefazodoneThe risk or severity of adverse effects can be increased when Etifoxine is combined with Nefazodone.Approved, Withdrawn
NitrazepamThe risk or severity of adverse effects can be increased when Nitrazepam is combined with Etifoxine.Approved
Nitrous oxideThe risk or severity of adverse effects can be increased when Nitrous oxide is combined with Etifoxine.Approved, Vet Approved
NorfluraneThe risk or severity of adverse effects can be increased when Etifoxine is combined with Norflurane.Investigational
NormethadoneThe risk or severity of adverse effects can be increased when Etifoxine is combined with Normethadone.Approved, Illicit
NortriptylineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Nortriptyline.Approved
OlanzapineThe risk or severity of adverse effects can be increased when Olanzapine is combined with Etifoxine.Approved, Investigational
OlopatadineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Olopatadine.Approved
OndansetronThe risk or severity of adverse effects can be increased when Ondansetron is combined with Etifoxine.Approved
OpiumThe risk or severity of adverse effects can be increased when Etifoxine is combined with Opium.Approved, Illicit
OrphenadrineEtifoxine may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantThe risk or severity of adverse effects can be increased when Osanetant is combined with Etifoxine.Investigational
OxazepamThe risk or severity of adverse effects can be increased when Oxazepam is combined with Etifoxine.Approved
OxethazaineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Oxethazaine.Investigational
OxprenololThe risk or severity of adverse effects can be increased when Oxprenolol is combined with Etifoxine.Approved
OxybuprocaineThe risk or severity of adverse effects can be increased when Oxybuprocaine is combined with Etifoxine.Approved
OxycodoneThe risk or severity of adverse effects can be increased when Oxycodone is combined with Etifoxine.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Etifoxine.Approved, Investigational, Vet Approved
PaliperidoneThe risk or severity of adverse effects can be increased when Paliperidone is combined with Etifoxine.Approved
ParaldehydeEtifoxine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ParoxetineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Paroxetine.Approved, Investigational
PenfluridolThe risk or severity of adverse effects can be increased when Etifoxine is combined with Penfluridol.Experimental
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Etifoxine.Approved, Vet Approved
PentobarbitalThe risk or severity of adverse effects can be increased when Pentobarbital is combined with Etifoxine.Approved, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Etifoxine.Approved
PerazineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Perazine.Investigational
PerospironeThe risk or severity of adverse effects can be increased when Perospirone is combined with Etifoxine.Approved
PerphenazineThe risk or severity of adverse effects can be increased when Perphenazine is combined with Etifoxine.Approved
PethidineThe risk or severity of adverse effects can be increased when Pethidine is combined with Etifoxine.Approved
PhenazocineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Phenazocine.Experimental
PhenibutThe risk or severity of adverse effects can be increased when Etifoxine is combined with Phenibut.Experimental
PhenobarbitalThe risk or severity of adverse effects can be increased when Phenobarbital is combined with Etifoxine.Approved
PhenoperidineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Phenoperidine.Experimental
PhenoxyethanolThe risk or severity of adverse effects can be increased when Etifoxine is combined with Phenoxyethanol.Approved
PhenytoinThe risk or severity of adverse effects can be increased when Etifoxine is combined with Phenytoin.Approved, Vet Approved
PimozideThe risk or severity of adverse effects can be increased when Pimozide is combined with Etifoxine.Approved
PipamperoneThe risk or severity of adverse effects can be increased when Etifoxine is combined with Pipamperone.Approved
PipotiazineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Pipotiazine.Approved
PiritramideThe risk or severity of adverse effects can be increased when Etifoxine is combined with Piritramide.Investigational
PizotifenThe risk or severity of adverse effects can be increased when Etifoxine is combined with Pizotifen.Approved
PomalidomideThe risk or severity of adverse effects can be increased when Etifoxine is combined with Pomalidomide.Approved
PramipexoleEtifoxine may increase the sedative activities of Pramipexole.Approved, Investigational
PramocaineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Pramocaine.Approved
PrazepamThe risk or severity of adverse effects can be increased when Prazepam is combined with Etifoxine.Approved, Illicit
PregabalinThe risk or severity of adverse effects can be increased when Pregabalin is combined with Etifoxine.Approved, Illicit, Investigational
PrilocaineThe risk or severity of adverse effects can be increased when Prilocaine is combined with Etifoxine.Approved
PrimidoneThe risk or severity of adverse effects can be increased when Etifoxine is combined with Primidone.Approved, Vet Approved
ProcaineThe risk or severity of adverse effects can be increased when Procaine is combined with Etifoxine.Approved, Investigational, Vet Approved
ProchlorperazineThe risk or severity of adverse effects can be increased when Prochlorperazine is combined with Etifoxine.Approved, Vet Approved
PromazineThe risk or severity of adverse effects can be increased when Promazine is combined with Etifoxine.Approved, Vet Approved
PromethazineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Promethazine.Approved
PropanididThe risk or severity of adverse effects can be increased when Etifoxine is combined with Propanidid.Experimental
ProparacaineThe risk or severity of adverse effects can be increased when Proparacaine is combined with Etifoxine.Approved, Vet Approved
PropofolThe risk or severity of adverse effects can be increased when Propofol is combined with Etifoxine.Approved, Investigational, Vet Approved
PropoxycaineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Propoxycaine.Approved
ProtriptylineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Protriptyline.Approved
ProxibarbalThe risk or severity of adverse effects can be increased when Etifoxine is combined with Proxibarbal.Experimental
PSD502The risk or severity of adverse effects can be increased when PSD502 is combined with Etifoxine.Investigational
QuazepamThe risk or severity of adverse effects can be increased when Quazepam is combined with Etifoxine.Approved, Illicit
QuetiapineThe risk or severity of adverse effects can be increased when Quetiapine is combined with Etifoxine.Approved
QuinisocaineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Quinisocaine.Experimental
RacloprideThe risk or severity of adverse effects can be increased when Etifoxine is combined with Raclopride.Investigational
RamelteonThe risk or severity of adverse effects can be increased when Etifoxine is combined with Ramelteon.Approved, Investigational
RemifentanilThe risk or severity of adverse effects can be increased when Remifentanil is combined with Etifoxine.Approved
RemoxiprideThe risk or severity of adverse effects can be increased when Remoxipride is combined with Etifoxine.Approved, Withdrawn
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Etifoxine.Approved
RisperidoneThe risk or severity of adverse effects can be increased when Risperidone is combined with Etifoxine.Approved, Investigational
RitanserinThe risk or severity of adverse effects can be increased when Etifoxine is combined with Ritanserin.Investigational
RomifidineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Romifidine.Vet Approved
RopiniroleEtifoxine may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineThe risk or severity of adverse effects can be increased when Ropivacaine is combined with Etifoxine.Approved
RotigotineEtifoxine may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Etifoxine.Approved
ScopolamineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Scopolamine.Approved
SecobarbitalThe risk or severity of adverse effects can be increased when Secobarbital is combined with Etifoxine.Approved, Vet Approved
SepranoloneThe risk or severity of adverse effects can be increased when Etifoxine is combined with Sepranolone.Investigational
SertindoleThe risk or severity of adverse effects can be increased when Sertindole is combined with Etifoxine.Approved, Withdrawn
SertralineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Sertraline.Approved
SevofluraneThe risk or severity of adverse effects can be increased when Sevoflurane is combined with Etifoxine.Approved, Vet Approved
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Etifoxine.Approved
StiripentolThe risk or severity of adverse effects can be increased when Etifoxine is combined with Stiripentol.Approved
SufentanilThe risk or severity of adverse effects can be increased when Sufentanil is combined with Etifoxine.Approved, Investigational
SulpirideThe risk or severity of adverse effects can be increased when Sulpiride is combined with Etifoxine.Approved
SultoprideThe risk or severity of adverse effects can be increased when Etifoxine is combined with Sultopride.Experimental
SuvorexantEtifoxine may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TandospironeThe risk or severity of adverse effects can be increased when Etifoxine is combined with Tandospirone.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Etifoxine.Approved
TasimelteonThe risk or severity of adverse effects can be increased when Etifoxine is combined with Tasimelteon.Approved
TemazepamThe risk or severity of adverse effects can be increased when Temazepam is combined with Etifoxine.Approved
TetrabenazineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Tetrabenazine.Approved
TetracaineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Tetracaine.Approved, Vet Approved
TetrahydropalmatineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Tetrahydropalmatine.Investigational
TetrodotoxinThe risk or severity of adverse effects can be increased when Tetrodotoxin is combined with Etifoxine.Investigational
ThalidomideEtifoxine may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.Approved, Investigational, Withdrawn
ThiamylalThe risk or severity of adverse effects can be increased when Thiamylal is combined with Etifoxine.Approved, Vet Approved
ThiopentalThe risk or severity of adverse effects can be increased when Thiopental is combined with Etifoxine.Approved, Vet Approved
ThioridazineThe risk or severity of adverse effects can be increased when Thioridazine is combined with Etifoxine.Withdrawn
ThiothixeneThe risk or severity of adverse effects can be increased when Thiothixene is combined with Etifoxine.Approved
TiagabineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Tiagabine.Approved
TiaprideThe risk or severity of adverse effects can be increased when Etifoxine is combined with Tiapride.Approved, Investigational
TiletamineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Tiletamine.Vet Approved
TilidineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Tilidine.Experimental
TizanidineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Tizanidine.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Etifoxine is combined with Tolcapone.Approved, Withdrawn
TopiramateThe risk or severity of adverse effects can be increased when Etifoxine is combined with Topiramate.Approved
TramadolThe risk or severity of adverse effects can be increased when Tramadol is combined with Etifoxine.Approved, Investigational
Trans-2-PhenylcyclopropylamineThe risk or severity of adverse effects can be increased when Trans-2-Phenylcyclopropylamine is combined with Etifoxine.Experimental
TranylcypromineThe risk or severity of adverse effects can be increased when Tranylcypromine is combined with Etifoxine.Approved
TrazodoneThe risk or severity of adverse effects can be increased when Trazodone is combined with Etifoxine.Approved, Investigational
TriazolamThe risk or severity of adverse effects can be increased when Triazolam is combined with Etifoxine.Approved
Tricaine methanesulfonateThe risk or severity of adverse effects can be increased when Etifoxine is combined with Tricaine methanesulfonate.Vet Approved
TrichloroethyleneThe risk or severity of adverse effects can be increased when Etifoxine is combined with Trichloroethylene.Experimental
TrifluoperazineThe risk or severity of adverse effects can be increased when Trifluoperazine is combined with Etifoxine.Approved
TrifluperidolThe risk or severity of adverse effects can be increased when Etifoxine is combined with Trifluperidol.Experimental
TriflupromazineThe risk or severity of adverse effects can be increased when Triflupromazine is combined with Etifoxine.Approved, Vet Approved
TrimipramineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Trimipramine.Approved
TriprolidineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Triprolidine.Approved
Valproic AcidThe risk or severity of adverse effects can be increased when Valproic Acid is combined with Etifoxine.Approved, Investigational
VenlafaxineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Venlafaxine.Approved
VeraliprideThe risk or severity of adverse effects can be increased when Etifoxine is combined with Veralipride.Experimental
VigabatrinThe risk or severity of adverse effects can be increased when Etifoxine is combined with Vigabatrin.Approved
Vinyl etherThe risk or severity of adverse effects can be increased when Etifoxine is combined with Vinyl ether.Experimental
VortioxetineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Vortioxetine.Approved
XenonThe risk or severity of adverse effects can be increased when Etifoxine is combined with Xenon.Experimental
XylazineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Xylazine.Vet Approved
YohimbineThe therapeutic efficacy of Etifoxine can be decreased when used in combination with Yohimbine.Approved, Vet Approved
ZaleplonThe risk or severity of adverse effects can be increased when Zaleplon is combined with Etifoxine.Approved, Illicit, Investigational
ZiconotideThe risk or severity of adverse effects can be increased when Etifoxine is combined with Ziconotide.Approved
ZimelidineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Zimelidine.Withdrawn
ZiprasidoneThe risk or severity of adverse effects can be increased when Ziprasidone is combined with Etifoxine.Approved
ZolazepamThe risk or severity of adverse effects can be increased when Etifoxine is combined with Zolazepam.Vet Approved
ZolpidemEtifoxine may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideThe risk or severity of adverse effects can be increased when Etifoxine is combined with Zonisamide.Approved, Investigational
ZopicloneThe risk or severity of adverse effects can be increased when Zopiclone is combined with Etifoxine.Approved
ZotepineThe risk or severity of adverse effects can be increased when Etifoxine is combined with Zotepine.Approved
ZuclopenthixolThe risk or severity of adverse effects can be increased when Zuclopenthixol is combined with Etifoxine.Approved, Investigational
Food Interactions
Not Available

References

Synthesis Reference

U.S. Patent 3,725,404.

General References
Not Available
External Links
KEGG Drug
D07320
ChemSpider
28547
ChEBI
135272
ChEMBL
CHEMBL2106227
Drugs.com
Drugs.com Drug Page
Wikipedia
Etifoxine
ATC Codes
N05BX03 — Etifoxine
AHFS Codes
Not Available
PDB Entries
Not Available
FDA label
Not Available
MSDS
Not Available

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3CompletedBasic ScienceHealthy Volunteers1
3Unknown StatusBasic ScienceVolunteers Aged Between 65 and 75 Years Old1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)90-92U.S. Patent 3,725,404.
Predicted Properties
PropertyValueSource
Water Solubility0.00216 mg/mLALOGPS
logP4.52ALOGPS
logP4.59ChemAxon
logS-5.1ALOGPS
pKa (Strongest Basic)5.18ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area33.62 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity87.23 m3·mol-1ChemAxon
Polarizability32.25 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as benzoxazines. These are organic compounds containing a benzene fused to an oxazine ring (a six-membered aliphatic ring with four carbon atoms, one oxygen atom, and one nitrogen atom).
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Benzoxazines
Sub Class
Not Available
Direct Parent
Benzoxazines
Alternative Parents
Benzene and substituted derivatives / Aryl chlorides / Isoureas / Propargyl-type 1,3-dipolar organic compounds / Oxacyclic compounds / Azacyclic compounds / Organopnictogen compounds / Organooxygen compounds / Organonitrogen compounds / Organochlorides
show 1 more
Substituents
Benzoxazine / Aryl chloride / Aryl halide / Monocyclic benzene moiety / Benzenoid / Isourea / Oxacycle / Azacycle / Propargyl-type 1,3-dipolar organic compound / Organic 1,3-dipolar compound
show 9 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available

Drug created on June 10, 2014 12:03 / Updated on October 02, 2017 06:12