Identification

Name
Paraldehyde
Accession Number
DB09117
Type
Small Molecule
Groups
Approved, Investigational
Description

Paraldehyde is the cyclic trimer of acetaldehyde molecules. It was introduced into clinical practice in the UK by the Italian physician Vincenzo Cervello in 1882. It is a central nervous system depressant and was soon found to be an effective anticonvulsant, hypnotic and sedative. It was included in some cough medicines as an expectorant (though there is no known mechanism for this function beyond the placebo effect).

Structure
Thumb
Synonyms
Not Available
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Paraldehyde Inj Bp 100%Liquid100 %Intramuscular; IntravenousDavid Bull Laboratories (Pty) Ltd.1991-12-311999-08-10Canada
Paraldehyde Injection BPLiquid100 %Intramuscular; IntravenousOmega Laboratories Ltd2012-02-082015-12-11Canada
Paraldehyde Injection BPLiquid100 %Intramuscular; IntravenousPharmascience Inc1998-09-102013-03-14Canada
Categories
UNII
S6M3YBG8QA
CAS number
123-63-7
Weight
Average: 132.1577
Monoisotopic: 132.07864425
Chemical Formula
C6H12O3
InChI Key
SQYNKIJPMDEDEG-UHFFFAOYSA-N
InChI
InChI=1S/C6H12O3/c1-4-7-5(2)9-6(3)8-4/h4-6H,1-3H3
IUPAC Name
2,4,6-trimethyl-1,3,5-trioxane
SMILES
CC1OC(C)OC(C)O1

Pharmacology

Indication

Paraldehyde was used historically as a sedative and hypnotic [1]. It has been used in the treatment of seizures as an anticonvulsant [2].

Structured Indications
Not Available
Pharmacodynamics

Paraldehyde blocks neuromuscular transmission [3].

Mechanism of action

Paraldehyde is believed to reduce the release of acetylcholine in response to neuronal depolarization [3]. The exact mechanism of this effect is unknown.

Absorption

93% of orally administered paraldehyde is absorbed from the gastrointestinal tract.

Volume of distribution
Not Available
Protein binding
Not Available
Metabolism

Paraldehyde is believed to undergo depolymerization to acetaldehyde followed by oxidation by aldehyde dehydrogenase [A19378]. It is thought to ultimately be metabolized to carbon dioxide and water.

Route of elimination

70-80% is metabolized to carbon dioxide and subsequently exhaled [4]. 11-28% is exhaled as the parent compound. 0.1-2.5% is excreted in the urine as the parent compound.

Half life

The mean half life is 7.5 hours in a range if 3.5-9.5 hours [4].

Clearance
Not Available
Toxicity

Paraldehyde overdosage can produce headache, nausea, drowsiness, unconsciousness, coma, severe hypotension, respiratory depression, pulmonary edema and hemorrhages, and right-side heart failure [4]. Inhalation of paraldehyde can produce sore throat, headache, dizziness, nausea, drowsiness and unconsciousness but exposure via this route is rare. Chronic use is dependence forming and withdrawal proceeds similarly to ethanol withdrawal producing hallucinations and convulsions. Toxic hepatitis and nephritis have been observed during chronic use.

The acute LD50 values determined for various species are as follows [4]:

Rabbit - 3.3-5 g/kg (oral) Rat - 1.5-1.65 g/kg (oral), 1.3-1.45 g/kg (i.p.) Dog - 3-4 g/kg (oral) Mouse - 2.75 (oral) Cat - 3.3 (oral)

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
7-Nitroindazole7-Nitroindazole may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Experimental
AcepromazineAcepromazine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Vet Approved
AceprometazineAceprometazine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
AdipiplonAdipiplon may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Investigational
AgomelatineAgomelatine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
AlaproclateThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Alaproclate.Experimental
AlfaxaloneAlfaxalone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Vet Approved
AlfentanilAlfentanil may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit
AllopregnanoloneAllopregnanolone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Investigational
AlphacetylmethadolAlphacetylmethadol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Experimental, Illicit
AlphaprodineAlphaprodine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Illicit
AlprazolamAlprazolam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit, Investigational
AmisulprideAmisulpride may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
AmitriptylineAmitriptyline may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
AmobarbitalAmobarbital may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit
AmoxapineAmoxapine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
AmperozideAmperozide may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Experimental
AripiprazoleAripiprazole may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
ArticaineArticaine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
AsenapineAsenapine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
AzaperoneAzaperone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Investigational, Vet Approved
AzelastineAzelastine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
BaclofenBaclofen may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
BarbitalBarbital may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Illicit
BenperidolBenperidol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Investigational
BenzocaineBenzocaine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
Benzyl alcoholBenzyl alcohol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
BrexpiprazoleBrexpiprazole may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
BrimonidineBrimonidine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
BromazepamBromazepam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit
BromisovalBromisoval may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Experimental
BromperidolBromperidol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Investigational
BrompheniramineBrompheniramine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
BrotizolamBrotizolam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational, Withdrawn
BupivacaineBupivacaine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
BuprenorphineParaldehyde may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.Approved, Illicit, Investigational, Vet Approved
BuspironeBuspirone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
ButabarbitalButabarbital may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit
ButacaineButacaine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Vet Approved
ButalbitalButalbital may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit
ButambenButamben may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ButethalButethal may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit
ButorphanolButorphanol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit, Vet Approved
CanertinibCanertinib may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Investigational
CarbamazepineCarbamazepine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
CarbinoxamineCarbinoxamine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
CarfentanilCarfentanil may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Illicit, Investigational, Vet Approved
CarisoprodolCarisoprodol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
CetirizineCetirizine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
Chloral hydrateChloral hydrate may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit, Vet Approved
ChlordiazepoxideChlordiazepoxide may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit
ChlormezanoneChlormezanone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational, Withdrawn
ChloroprocaineChloroprocaine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ChlorphenamineChlorphenamine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ChlorpromazineChlorpromazine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Vet Approved
ChlorprothixeneChlorprothixene may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational, Withdrawn
ChlorzoxazoneChlorzoxazone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
CinchocaineCinchocaine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Vet Approved
CitalopramThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Citalopram.Approved
ClemastineClemastine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ClidiniumClidinium may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ClobazamClobazam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit
clomethiazoleclomethiazole may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Investigational
ClomipramineClomipramine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Vet Approved
ClonazepamClonazepam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit
ClonidineClonidine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ClopenthixolClopenthixol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Experimental
ClorazepateClorazepate may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit
ClothiapineClothiapine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Experimental
ClozapineClozapine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
CocaineCocaine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit
CodeineCodeine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit
CyclizineCyclizine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
CyclobenzaprineCyclobenzaprine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
CyproheptadineCyproheptadine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
DantroleneDantrolene may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
DapiprazoleDapiprazole may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
DapoxetineThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Dapoxetine.Investigational
DeramciclaneDeramciclane may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Investigational
DesfluraneDesflurane may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
DesipramineDesipramine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
DesloratadineDesloratadine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
DesvenlafaxineThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Desvenlafaxine.Approved
DetomidineDetomidine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Vet Approved
DexbrompheniramineDexbrompheniramine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
DexmedetomidineDexmedetomidine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Vet Approved
DextromoramideDextromoramide may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Experimental, Illicit
DextropropoxypheneDextropropoxyphene may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit, Investigational, Withdrawn
DezocineDezocine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
DiazepamDiazepam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit, Vet Approved
Diethyl etherDiethyl ether may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Experimental
DifenoxinDifenoxin may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit
DihydrocodeineDihydrocodeine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit
DihydroetorphineDihydroetorphine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Experimental, Illicit
DihydromorphineDihydromorphine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Experimental, Illicit
DimenhydrinateDimenhydrinate may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
DiphenhydramineDiphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
DiphenoxylateDiphenoxylate may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit
DisulfiramThe serum concentration of Paraldehyde can be increased when it is combined with Disulfiram.Approved
DixyrazineDixyrazine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Experimental
DoramectinDoramectin may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Vet Approved
DoxepinDoxepin may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
DoxylamineDoxylamine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Vet Approved
DPDPEDPDPE may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Experimental
DronabinolDronabinol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit
DroperidolDroperidol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Vet Approved
DrotebanolDrotebanol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Experimental, Illicit
DuloxetineThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Duloxetine.Approved
DyclonineDyclonine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
EcgonineEcgonine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Experimental, Illicit
EcopipamEcopipam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Investigational
EfavirenzEfavirenz may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
EltanoloneEltanolone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Investigational
EnfluraneEnflurane may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational, Vet Approved
EntacaponeEntacapone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
EscitalopramThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Escitalopram.Approved, Investigational
EstazolamEstazolam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit
EszopicloneEszopiclone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
EthanolEthanol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
EthchlorvynolEthchlorvynol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit, Withdrawn
EthosuximideEthosuximide may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
EthotoinEthotoin may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
Ethyl carbamateEthyl carbamate may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Withdrawn
Ethyl chlorideEthyl chloride may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Experimental, Investigational
Ethyl loflazepateEthyl loflazepate may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit
EthylmorphineEthylmorphine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit
EtidocaineEtidocaine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
EtifoxineEtifoxine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Investigational, Withdrawn
EtizolamEtizolam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
EtomidateEtomidate may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
EtoperidoneThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Etoperidone.Withdrawn
EtorphineEtorphine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Illicit, Vet Approved
EzogabineEzogabine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
FelbamateFelbamate may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
FencamfamineFencamfamine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit, Withdrawn
FentanylFentanyl may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit, Investigational, Vet Approved
FexofenadineFexofenadine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
FlibanserinFlibanserin may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
FluanisoneFluanisone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Experimental
FludiazepamFludiazepam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit
FlunarizineFlunarizine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
FlunitrazepamFlunitrazepam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit
FluoxetineThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Fluoxetine.Approved, Vet Approved
FlupentixolFlupentixol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Withdrawn
FluphenazineFluphenazine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
FlurazepamFlurazepam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit
FluspirileneFluspirilene may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
Fluticasone propionateFluticasone propionate may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
FluvoxamineFluvoxamine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
FosphenytoinFosphenytoin may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
FospropofolFospropofol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit, Investigational
GabapentinGabapentin may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
Gabapentin EnacarbilGabapentin Enacarbil may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
Gamma Hydroxybutyric AcidGamma Hydroxybutyric Acid may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit, Investigational
GepironeGepirone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Investigational
GlutethimideGlutethimide may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit
GuanfacineGuanfacine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
HalazepamHalazepam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit, Withdrawn
HaloperidolHaloperidol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
HalothaneHalothane may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Vet Approved
HeroinHeroin may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit, Investigational
HexobarbitalHexobarbital may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
HydrocodoneParaldehyde may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.Approved, Illicit
HydromorphoneHydromorphone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit
HydroxyzineHydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
IloperidoneIloperidone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ImipramineImipramine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
IndalpineThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Indalpine.Investigational, Withdrawn
IndiplonIndiplon may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Investigational
IsofluraneIsoflurane may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Vet Approved
KetamineKetamine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Vet Approved
KetazolamKetazolam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
KetobemidoneKetobemidone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
LamotrigineLamotrigine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
LevetiracetamLevetiracetam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
LevobupivacaineLevobupivacaine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
LevocabastineLevocabastine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
LevocetirizineLevocetirizine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
LevodopaLevodopa may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
Levomethadyl AcetateLevomethadyl Acetate may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
LevomilnacipranThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Levomilnacipran.Approved
LevorphanolLevorphanol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
LidocaineLidocaine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Vet Approved
LithiumLithium may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
LofentanilLofentanil may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Illicit
LoprazolamLoprazolam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Experimental
LoratadineLoratadine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
LorazepamLorazepam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
LormetazepamLormetazepam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
LoxapineLoxapine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
LurasidoneLurasidone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
Magnesium SulfateMagnesium Sulfate may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Vet Approved
MaprotilineMaprotiline may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
MebicarMebicar may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Experimental
MeclizineMeclizine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
MedazepamMedazepam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Experimental
MedetomidineMedetomidine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Vet Approved
MefloquineThe therapeutic efficacy of Paraldehyde can be decreased when used in combination with Mefloquine.Approved
MelatoninMelatonin may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Nutraceutical, Vet Approved
MelperoneMelperone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
MepivacaineMepivacaine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Vet Approved
MeprobamateMeprobamate may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit
MeptazinolMeptazinol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Experimental
MesoridazineMesoridazine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
MetaxaloneMetaxalone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
MethadoneMethadone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
Methadyl AcetateMethadyl Acetate may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit
MethapyrileneMethapyrilene may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Withdrawn
MethaqualoneMethaqualone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Illicit, Withdrawn
MethocarbamolMethocarbamol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Vet Approved
MethohexitalMethohexital may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
MethotrimeprazineParaldehyde may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.Approved
MethoxyfluraneMethoxyflurane may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational, Vet Approved
MethsuximideMethsuximide may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
MethylecgonineMethylecgonine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Experimental
MethylphenobarbitalMethylphenobarbital may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
MetyrosineParaldehyde may increase the sedative activities of Metyrosine.Approved
MianserinThe therapeutic efficacy of Paraldehyde can be decreased when used in combination with Mianserin.Approved, Investigational
MidazolamMidazolam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit
MilnacipranThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Milnacipran.Approved
MinocyclineMinocycline may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
MirtazapineParaldehyde may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.Approved
MolindoneMolindone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
MorphineMorphine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
NabiloneNabilone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
NalbuphineNalbuphine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
NefazodoneThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Nefazodone.Approved, Withdrawn
NitrazepamNitrazepam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
Nitrous oxideNitrous oxide may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Vet Approved
NorfluraneNorflurane may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Investigational
NormethadoneNormethadone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit
NortriptylineNortriptyline may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
OlanzapineOlanzapine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
OlopatadineOlopatadine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
OndansetronOndansetron may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
OpiumOpium may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit
OrlistatThe serum concentration of Paraldehyde can be decreased when it is combined with Orlistat.Approved, Investigational
OrphenadrineParaldehyde may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.Approved
OsanetantOsanetant may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Investigational
OxazepamOxazepam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
OxethazaineOxethazaine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
OxprenololOxprenolol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
OxybuprocaineOxybuprocaine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
OxycodoneOxycodone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit, Investigational
OxymorphoneOxymorphone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational, Vet Approved
PaliperidonePaliperidone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ParoxetineThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Paroxetine.Approved, Investigational
PenfluridolPenfluridol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Experimental
PentazocinePentazocine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Vet Approved
PentobarbitalPentobarbital may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Vet Approved
PerampanelPerampanel may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
PerazinePerazine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Investigational
PerospironePerospirone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
PerphenazinePerphenazine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
PethidinePethidine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
PhenazocinePhenazocine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Experimental
PhenibutPhenibut may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Experimental
PhenobarbitalPhenobarbital may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
PhenoperidinePhenoperidine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Experimental
PhenoxyethanolPhenoxyethanol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
PhenytoinPhenytoin may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Vet Approved
PimozidePimozide may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
PipamperonePipamperone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
PipotiazinePipotiazine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
PiritramidePiritramide may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Investigational
PizotifenPizotifen may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
PomalidomidePomalidomide may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
PramipexoleParaldehyde may increase the sedative activities of Pramipexole.Approved, Investigational
PramocainePramocaine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
PrazepamPrazepam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit
PregabalinPregabalin may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit, Investigational
PrilocainePrilocaine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
PrimidonePrimidone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Vet Approved
ProcaineProcaine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational, Vet Approved
ProchlorperazineProchlorperazine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Vet Approved
PromazinePromazine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Vet Approved
PromethazinePromethazine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
PropanididPropanidid may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Experimental
ProparacaineProparacaine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Vet Approved
PropofolPropofol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational, Vet Approved
PropoxycainePropoxycaine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ProtriptylineProtriptyline may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ProxibarbalProxibarbal may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Experimental
PSD502PSD502 may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Investigational
QuazepamQuazepam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit
QuetiapineQuetiapine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
QuinisocaineQuinisocaine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Experimental
RacloprideRaclopride may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Investigational
RamelteonRamelteon may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
RemifentanilRemifentanil may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
RemoxiprideRemoxipride may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Withdrawn
ReserpineReserpine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
RisperidoneRisperidone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
RitanserinRitanserin may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Investigational
RomifidineRomifidine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Vet Approved
RopiniroleParaldehyde may increase the sedative activities of Ropinirole.Approved, Investigational
RopivacaineRopivacaine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
RotigotineParaldehyde may increase the sedative activities of Rotigotine.Approved
RufinamideThe risk or severity of adverse effects can be increased when Rufinamide is combined with Paraldehyde.Approved
ScopolamineScopolamine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
SecobarbitalSecobarbital may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Vet Approved
SepranoloneSepranolone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Investigational
SertindoleSertindole may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational, Withdrawn
SertralineThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Sertraline.Approved
SevofluraneSevoflurane may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Vet Approved
Sodium oxybateSodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
StiripentolStiripentol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
SufentanilSufentanil may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
SulpirideSulpiride may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
SultoprideSultopride may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Experimental
SuvorexantParaldehyde may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.Approved
TandospironeTandospirone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Investigational
TapentadolTapentadol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
TasimelteonTasimelteon may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
TemazepamTemazepam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
TetrabenazineTetrabenazine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
TetracaineTetracaine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Vet Approved
TetrahydropalmatineTetrahydropalmatine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Investigational
TetrodotoxinTetrodotoxin may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Investigational
ThalidomideThalidomide may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational, Withdrawn
ThiamylalThiamylal may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Vet Approved
ThiopentalThiopental may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Vet Approved
ThioridazineThioridazine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Withdrawn
ThiothixeneThiothixene may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
TiagabineTiagabine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
TiaprideTiapride may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
TiletamineTiletamine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Vet Approved
TilidineTilidine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Experimental
TizanidineTizanidine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
TolcaponeTolcapone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Withdrawn
TopiramateTopiramate may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
TramadolTramadol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
Trans-2-PhenylcyclopropylamineTrans-2-Phenylcyclopropylamine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Experimental
TranylcypromineTranylcypromine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
TrazodoneTrazodone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
TriazolamTriazolam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
Tricaine methanesulfonateTricaine methanesulfonate may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Vet Approved
TrichloroethyleneTrichloroethylene may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
TrifluoperazineTrifluoperazine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
TrifluperidolTrifluperidol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Experimental
TriflupromazineTriflupromazine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Vet Approved
TrimipramineTrimipramine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
TriprolidineTriprolidine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
Valproic AcidValproic Acid may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
VenlafaxineThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Venlafaxine.Approved
VeraliprideVeralipride may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Experimental
VigabatrinVigabatrin may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
Vinyl etherVinyl ether may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Experimental
VortioxetineVortioxetine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
XenonXenon may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Experimental
XylazineXylazine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Vet Approved
ZaleplonZaleplon may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Illicit, Investigational
ZiconotideZiconotide may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ZimelidineThe risk or severity of adverse effects can be increased when Paraldehyde is combined with Zimelidine.Withdrawn
ZiprasidoneZiprasidone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ZolazepamZolazepam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Vet Approved
ZolpidemParaldehyde may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.Approved
ZonisamideZonisamide may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
ZopicloneZopiclone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved
ZotepineZotepine may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
ZuclopenthixolZuclopenthixol may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.Approved, Investigational
Food Interactions
Not Available

References

General References
  1. Lopez-Munoz F, Ucha-Udabe R, Alamo C: The history of barbiturates a century after their clinical introduction. Neuropsychiatr Dis Treat. 2005 Dec;1(4):329-43. [PubMed:18568113]
  2. Rowland AG, Gill AM, Stewart AB, Appleton RE, Al Kharusi A, Cramp C, Yeung LK: Review of the efficacy of rectal paraldehyde in the management of acute and prolonged tonic-clonic convulsions. Arch Dis Child. 2009 Sep;94(9):720-3. doi: 10.1136/adc.2009.157636. Epub 2009 Apr 8. [PubMed:19357123]
  3. NICHOLLS JG, QUILLIAM JP: The mechanism of action of paraldehyde and methylpentynol on neuromuscular transmission in the frog. Br J Pharmacol Chemother. 1956 Jun;11(2):151-5. [PubMed:13329331]
  4. Von Burg R, Stout T: Paraldehyde. J Appl Toxicol. 1991 Oct;11(5):379-81. [PubMed:1783744]
External Links
Human Metabolome Database
HMDB32456
KEGG Compound
C07834
PubChem Compound
31264
PubChem Substance
310265034
ChemSpider
21106173
ChEBI
27909
ChEMBL
CHEMBL1410743
ATC Codes
N05CC05 — Paraldehyde
MSDS
Download (89.6 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3CompletedTreatmentConvulsions / Refractory seizure disorders1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
LiquidIntramuscular; Intravenous100 %
Prices
Not Available
Patents
Not Available

Properties

State
Liquid
Experimental Properties
PropertyValueSource
melting point (°C)12Von Burg R, Stout T: Paraldehyde. J Appl Toxicol. 1991 Oct;11(5):379-81.
boiling point (°C)124Von Burg R, Stout T: Paraldehyde. J Appl Toxicol. 1991 Oct;11(5):379-81.
water solubility125g/LVon Burg R, Stout T: Paraldehyde. J Appl Toxicol. 1991 Oct;11(5):379-81.
logP0.73MSDS
Predicted Properties
PropertyValueSource
Water Solubility177.0 mg/mLALOGPS
logP0.33ALOGPS
logP0.88ChemAxon
logS0.13ALOGPS
pKa (Strongest Basic)-4ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area27.69 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity32.09 m3·mol-1ChemAxon
Polarizability14.15 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
GC-MS Spectrum - EI-BGC-MSsplash10-0005-9000000000-a3f03c0baa80a3369e84
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as trioxanes. These are compounds containing a six-member aliphatic saturated heterocycle made up of three oxygen atoms and three carbon atoms.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Trioxanes
Sub Class
Not Available
Direct Parent
Trioxanes
Alternative Parents
Oxacyclic compounds / Acetals / Hydrocarbon derivatives
Substituents
1,3,5-trioxane / Oxacycle / Acetal / Organic oxygen compound / Hydrocarbon derivative / Organooxygen compound / Aliphatic heteromonocyclic compound
Molecular Framework
Aliphatic heteromonocyclic compounds
External Descriptors
trioxane (CHEBI:27909)

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
No
Actions
Substrate
General Function
Electron carrier activity
Specific Function
Not Available
Gene Name
ALDH2
Uniprot ID
P05091
Uniprot Name
Aldehyde dehydrogenase, mitochondrial
Molecular Weight
56380.93 Da
References
  1. Von Burg R, Stout T: Paraldehyde. J Appl Toxicol. 1991 Oct;11(5):379-81. [PubMed:1783744]

Drug created on September 22, 2015 13:31 / Updated on November 09, 2017 04:45