Hypnotics and Sedatives

Name
Hypnotics and Sedatives
Accession Number
DBCAT000452
Description

Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.

ATC Classification
Drugs
DrugDrug Description
EthchlorvynolA sedative hypnotic agent used for the short-term management of insomnia.
TemazepamA short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and insomnia.
PentobarbitalA barbiturate drug used to induce sleep, cause sedation, and control certain types of seizures.
EszopicloneA sedative-hypnotic used in the treatment of insomnia, improving both the latency phase and the maintenance phase of sleep.
SecobarbitalA barbiturate used for the short-term treatment of insomnia.
ZolpidemA sedative hypnotic used for the short-term treatment of insomnia to improve sleep latency.
ThiopentalA barbiturate used to induce general anesthesia, treat convulsions, and reduce intracranial pressure.
DexmedetomidineAn alpha-2 agonist used for sedation during various procedures.
MidazolamA short-acting injectable benzodiazepine with rapid onset that is commonly used in seizures, anesthesia and anxiety disorders.
FlurazepamA long-acting benzodiazepine with a rapid onset of action that is commonly used to treat insomnia.
ZaleplonA sedative used for short term treatment of insomnia in adults.
ZopicloneA nonbenzodiazepine hypnotic used for the short-term management of insomnia.
AmobarbitalA barbiturate derivative used for the induction of sedation during procedures, short-term management of insomnia, and acute management of refractory tonic-clonic seizures.
ButobarbitalFor the treatment of insomnia.
HexobarbitalFor the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful...
GlutethimideFor the treatment of insomnia.
BarbitalA long-acting barbiturate that depresses most metabolic processes at high doses. It is used as a hypnotic and sedative and may induce dependence. Barbital is also used in veterinary practice...
Chloral hydrateA mild hypnotic used for experimental purposes that was previously used for the treatment of insomnia.
QuazepamA long -acting benzodiazepine used to manage insomnia.
NitrazepamA long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, insomnia, and seizures.
MethaqualoneFor the treatment of insomnia, and as a sedative and muscle relaxant.
ClomethiazoleInvestigated for use/treatment in strokes.
BrotizolamBrotizolam is indicated for 2-4 weeks in the treatment of severe or debilitating insomnia.
ParaldehydeA central nervous system depressant previously used to control convulsions due to various clinical causes, including tetanus, status epilepticus, and convulsive drugs.
ProxibarbalProxibarbal is a derivative of barbiturates, which has been used to treat migraines. Proxibarbal was approved in France but was withdrawn from the market due to the risk of inducing...
BromisovalNot Annotated
MethylphenobarbitalFor the relief of anxiety, tension, and apprehension, also used as an anticonvulsant for the treatment of epilepsy.
ThiamylalUsed for the production of complete anaesthesia of short duration, for the induction of general anaesthesia, and for inducing a hypnotic state.
PhenobarbitalA long-lasting barbiturate and anticonvulsant used in the treatment of all types of seizures, except for absent seizures.
LormetazepamFor the treatment of short-term insomnia
ButalbitalA barbiturate drug used for symptomatic treatment of tension-type headache in various combinations with acetaminophen, aspirin, caffeine, and codeine.
LorazepamA long-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and seizures.
ButabarbitalA barbiturate drug used as a sedative and hypnotic.
EtomidateA short-acting intravenous anesthetic indicated for the induction of anesthesia and supplementation of subpotent anesthesia during short operative procedures.
MeprobamateAn anxiolytic drug used for the short-term management of anxiety symptoms.
ChlordiazepoxideA benzodiazepine used to treat the withdrawal symptoms of acute alcoholism, to treat preoperative anxiety, and to treat anxiety over a short term period.
PropofolA medication used in general anesthesia and for sedation.
DiazepamA long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures.
OxazepamAn intermediate-acting benzodiazepine with slow onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawals, and insomnia.
RemifentanilAn opioid analgesic used in anesthesia.
DiphenhydramineA H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes.
MethapyrileneMethapyrilene, formerly marketed in many drug products, was shown to be a potent carcinogen. Manufacturers voluntarily withdrew methapyriline drug products from the market in May and June 1979.
FospropofolA sedative-­hypnotic agent indicated for monitored anesthesia care (MAC) sedation in adult patients undergoing diagnostic or therapeutic procedures.
AzaperoneAzaperone is a pyridinylpiperazine and butyrophenone agent that is capable of eliciting neuroleptic sedative and antiemetic effects. It is subsequently employed predominantly as a veterinary tranquilizer and mainly for pigs...
MedetomidineMedetomidine is a synthetic compound used as a surgical anesthetic and analgesic. It is normally found as its hydrochloride salt, medetomidine hydrochloride. Medetomidine is an intravenously available alpha-2 adrenergic agonist....
XylazineXylazine is a clonidine analog which acts as an agonist at α2 adrenoceptors. Veterinarians also use xylazine as an emetic, especially in cats.
DetomidineUsed as a large animal sedative, primarily in horses.
AZD-3043AZD3043 has been used in trials studying the treatment and basic science of Safety, Sedation, Tolerability, and Pharmacokinetics.
IndiplonIndiplon has been used in trials studying the treatment of Insomnia and Depression.
MedazepamNot Annotated
PhenibutNot Annotated
FluanisoneNot Annotated
TalbutalFor use as a sedative and hypnotic.
MethohexitalAn anesthetic used to induce deep sedation.
PropiomazinePropiomazine is largely used for its antihistamininc sleep inducing effects in treating insomnia.
PrimidoneAn antiepileptic used to treat grand mal, psychomotor, and focal epileptic seizures.
TriazolamA benzodiazepine used for short term treatment of insomnia.
MethyprylonFor the treatment of insomnia.
EstazolamA benzodiazepine used for the short-term management of insomnia.
AprobarbitalAprobarbital is a barbiturate derivative synthesized in the 1920s by Ernst Preiswerk. It was determined that the substance was capable of demonstrating sedative, hypnotic, and anticonvulsant effects. A primary treatment...
HeptabarbitalUsed mainly for sedation and hypnosis.
DichloralphenazoneDichloralphenazone is a sedative composed of chloral hydrate and phenazone. It is typically found in combination products Nodolor and Midrin containing isometheptene and acetaminophen used for the relief of tension...
FlunitrazepamFor short-term treatment of severe insomnias, that are not responsive to other hypnotics.
CinolazepamFor the management of anxiety disorders or for the short-term relief of the symptoms of anxiety or anxiety associated with depressive symptoms.
TriclofosNot Annotated
ValnoctamideValnoctamide has been used in trials studying the treatment of Mania and Schizoaffective Disorder, Manic Type.
ValerianA plant used in some non-prescription natural health products.
ApronalideApronalide is approved in Japan. Apronalide has been withdrawn from the market in many other countries due to patient development of thrombocytopenic purpura .
PyrithyldioneNot Annotated
VinbarbitalNot Annotated
Acetylglycinamide chloral hydrateNot Annotated
AllobarbitalNot Annotated
LoprazolamLoprazolam is an imidazobenzodiazepine with anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. It is indicated for the short-term treatment of insomnia including difficulty in falling asleep and/or frequent...
HexapropymateNot Annotated
NiaprazineNiaprazine is a selective brain catecholamine depletor.
MethylpentynolNot Annotated
CyclobarbitalNot Annotated
VinylbitalNot Annotated
ReposalReposal is a barbiturate derivative invented in the 1960s in Denmark that has sedative, hypnotic and anticonvulsant properties. It was used primarily in the treatment of insomnia.
CarbromalNot Annotated
DoxefazepamNot Annotated
EmeproniumNot Annotated
BromazepamA short-acting benzodiazepine with intermediate onset commonly used to treat panic disorders and severe anxiety.
EtizolamIndicated for the treatment of generalized anxiety disorder with depression, panic disorder and insomnia.
AlprazolamA long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders and generalized anxiety in addition to anxiety associated with depression.
MelatoninAn endogenous hormone produced by the pineal gland that regulates sleep-wake cycles and when provided exogenously has beneficial effects on sleep-onset latency; available as an over-the-counter supplement.
ScopolamineAn anticholinergic used to treat excessive salivation, colicky abdominal pain, bradycardia, diverticulitis, IBS, and motion sickness.
RomifidineRomifidine is a veterinary drug utilized as a sedative primarily in large animals, most frequently horses. It is also used less commonly in a wide variety of other animal species....
RamelteonA melatonin receptor agonist used to treat insomnia.
TasimelteonA melatonin receptor agonist used to treat Non- 24-Hour Sleep-Wake Disorder.
OcinaplonInvestigated for use/treatment in anxiety disorders.
PagocloneFor the potential treatment of panic and anxiety disorders.
GedocarnilNot Annotated
BentazepamNot Annotated
S-EthylisothioureaS-Ethylisothiourea is a nitric oxide synthase inhibitor.
ChlorhexadolChlorhexadol is a sedative and hypnotic which is regulated in the United States as a Schedule III controlled substance. It is a derivative of chloral hydrate.
SuvorexantA orexin receptor antagonist used to treat insomnia that is characterized by difficulties with sleep onset and/or sleep maintenance.
DoxepinA psychotropic agent used for the treatment of depression, anxiety, manic-depressive disorder, and insomnia.
MepyramineAn antihistamine agent used for the symptomatic treatment of allergy, hypersensitivity reactions, and pruritic skin disorders.
PyrazolamNot Annotated
Drugs & Drug Targets
DrugTargetType
EthchlorvynolGABA(A) Receptortarget
TemazepamCytochrome P450 3A4enzyme
TemazepamCytochrome P450 2B6enzyme
TemazepamCytochrome P450 2C9enzyme
TemazepamGABA(A) Receptortarget
TemazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
PentobarbitalGamma-aminobutyric acid receptor subunit alpha-1target
PentobarbitalCytochrome P450 3A4enzyme
PentobarbitalGamma-aminobutyric acid receptor subunit alpha-4target
PentobarbitalGamma-aminobutyric acid receptor subunit alpha-6target
PentobarbitalGamma-aminobutyric acid receptor subunit alpha-2target
PentobarbitalGamma-aminobutyric acid receptor subunit alpha-3target
PentobarbitalGamma-aminobutyric acid receptor subunit alpha-5target
PentobarbitalNeuronal acetylcholine receptor subunit alpha-4target
PentobarbitalNeuronal acetylcholine receptor subunit alpha-7target
PentobarbitalGlutamate receptor 2target
PentobarbitalGlutamate receptor ionotropic, kainate 2target
PentobarbitalCytochrome P450 2C19enzyme
PentobarbitalCytochrome P450 2A6enzyme
PentobarbitalGABA(A) Receptortarget
PentobarbitalNMDA receptortarget
PentobarbitalNuclear receptor subfamily 1 group I member 2target
EszopicloneCytochrome P450 3A4enzyme
EszopicloneGamma-aminobutyric acid receptor subunit alpha-1target
EszopicloneGamma-aminobutyric acid receptor subunit alpha-2target
EszopicloneGamma-aminobutyric acid receptor subunit alpha-3target
EszopicloneGamma-aminobutyric acid receptor subunit alpha-5target
EszopicloneCytochrome P450 2C8enzyme
EszopicloneGABA(A) Receptortarget
SecobarbitalGamma-aminobutyric acid receptor subunit alpha-1target
SecobarbitalCytochrome P450 2C8enzyme
SecobarbitalCytochrome P450 2C9enzyme
SecobarbitalGamma-aminobutyric acid receptor subunit alpha-2target
SecobarbitalGamma-aminobutyric acid receptor subunit alpha-3target
SecobarbitalGamma-aminobutyric acid receptor subunit alpha-4target
SecobarbitalGamma-aminobutyric acid receptor subunit alpha-5target
SecobarbitalGamma-aminobutyric acid receptor subunit alpha-6target
SecobarbitalNeuronal acetylcholine receptor subunit alpha-4target
SecobarbitalNeuronal acetylcholine receptor subunit alpha-7target
SecobarbitalGlutamate receptor 2target
SecobarbitalGlutamate receptor ionotropic, kainate 2target
SecobarbitalCytochrome P450 1A2enzyme
SecobarbitalNMDA receptortarget
SecobarbitalCytochrome P450 2C19enzyme
ZolpidemGamma-aminobutyric acid receptor subunit alpha-1target
ZolpidemCytochrome P450 3A4enzyme
ZolpidemCytochrome P450 1A2enzyme
ZolpidemGamma-aminobutyric acid receptor subunit alpha-2target
ZolpidemGamma-aminobutyric acid receptor subunit alpha-3target
ZolpidemCytochrome P450 2C9enzyme
ZolpidemCytochrome P450 2C19enzyme
ZolpidemCytochrome P450 2D6enzyme
ZolpidemGamma-aminobutyric acid receptor subunit gamma-2target
ThiopentalGamma-aminobutyric acid receptor subunit alpha-1target
ThiopentalFatty-acid amide hydrolase 1target
ThiopentalGamma-aminobutyric acid receptor subunit alpha-2target
ThiopentalGamma-aminobutyric acid receptor subunit alpha-3target
ThiopentalGamma-aminobutyric acid receptor subunit alpha-4target
ThiopentalGamma-aminobutyric acid receptor subunit alpha-5target
ThiopentalGamma-aminobutyric acid receptor subunit alpha-6target
ThiopentalNeuronal acetylcholine receptor subunit alpha-4target
ThiopentalNeuronal acetylcholine receptor subunit alpha-7target
ThiopentalGlutamate receptor 2target
ThiopentalGlutamate receptor ionotropic, kainate 2target
ThiopentalCytochrome P450 3A Subfamilyenzyme
ThiopentalMuscarinic acetylcholine receptor M3target
ThiopentalCytochrome P450 2C19enzyme
DexmedetomidineAlpha-2A adrenergic receptortarget
DexmedetomidineCytochrome P450 2E1enzyme
DexmedetomidineCytochrome P450 1A2enzyme
DexmedetomidineCytochrome P450 1A1enzyme
DexmedetomidineCytochrome P450 2D6enzyme
MidazolamCytochrome P450 3A4enzyme
MidazolamCytochrome P450 3A5enzyme
MidazolamUDP-glucuronosyltransferase 1-4enzyme
MidazolamCytochrome P450 3A7enzyme
MidazolamGABA(A) Receptortarget
MidazolamGABA(A) Receptor Benzodiazepine Binding Sitetarget
FlurazepamCytochrome P450 3A4enzyme
FlurazepamP-glycoprotein 1transporter
FlurazepamCytochrome P450 2E1enzyme
FlurazepamCytochrome P450 2A6enzyme
FlurazepamSolute carrier family 22 member 2transporter
FlurazepamGABA(A) Receptortarget
FlurazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
ZaleplonGamma-aminobutyric acid receptor subunit alpha-1target
ZaleplonCytochrome P450 3A4enzyme
ZaleplonAldehyde oxidaseenzyme
ZaleplonCytochrome P450 3A5enzyme
ZaleplonCytochrome P450 3A7enzyme
ZopicloneTranslocator proteintarget
ZopicloneCytochrome P450 2C8enzyme
ZopicloneCytochrome P450 2C9enzyme
ZopicloneCytochrome P450 3A4enzyme
ZopicloneProstaglandin G/H synthase 1enzyme
ZopicloneGamma-aminobutyric acid receptor subunit alpha-1target
ZopicloneGamma-aminobutyric acid receptor subunit alpha-2target
ZopicloneGamma-aminobutyric acid receptor subunit alpha-3target
ZopicloneGamma-aminobutyric acid receptor subunit alpha-5target
ZopicloneCytochrome P450 2E1enzyme
AmobarbitalGamma-aminobutyric acid receptor subunit alpha-1target
AmobarbitalGamma-aminobutyric acid receptor subunit alpha-4target
AmobarbitalGamma-aminobutyric acid receptor subunit alpha-6target
AmobarbitalNeuronal acetylcholine receptor subunit alpha-4target
AmobarbitalNeuronal acetylcholine receptor subunit alpha-7target
AmobarbitalGlutamate receptor 2target
AmobarbitalGamma-aminobutyric acid receptor subunit alpha-2target
AmobarbitalGamma-aminobutyric acid receptor subunit alpha-3target
AmobarbitalGamma-aminobutyric acid receptor subunit alpha-5target
AmobarbitalGlutamate receptor ionotropic, kainate 2target
ButobarbitalGamma-aminobutyric acid receptor subunit alpha-1target
ButobarbitalGamma-aminobutyric acid receptor subunit alpha-2target
ButobarbitalGamma-aminobutyric acid receptor subunit alpha-3target
ButobarbitalGamma-aminobutyric acid receptor subunit alpha-4target
ButobarbitalGamma-aminobutyric acid receptor subunit alpha-5target
ButobarbitalGamma-aminobutyric acid receptor subunit alpha-6target
ButobarbitalNeuronal acetylcholine receptor subunit alpha-4target
ButobarbitalNeuronal acetylcholine receptor subunit alpha-7target
ButobarbitalGlutamate receptor 2target
ButobarbitalGlutamate receptor ionotropic, kainate 2target
HexobarbitalGamma-aminobutyric acid receptor subunit alpha-1target
HexobarbitalCytochrome P450 2C9enzyme
HexobarbitalCytochrome P450 2C19enzyme
HexobarbitalProstaglandin G/H synthase 1enzyme
HexobarbitalGamma-aminobutyric acid receptor subunit alpha-2target
HexobarbitalGamma-aminobutyric acid receptor subunit alpha-3target
HexobarbitalGamma-aminobutyric acid receptor subunit alpha-4target
HexobarbitalGamma-aminobutyric acid receptor subunit alpha-5target
HexobarbitalGamma-aminobutyric acid receptor subunit alpha-6target
HexobarbitalNeuronal acetylcholine receptor subunit alpha-4target
HexobarbitalNeuronal acetylcholine receptor subunit alpha-7target
HexobarbitalGlutamate receptor 2target
HexobarbitalGlutamate receptor ionotropic, kainate 2target
GlutethimideCholesterol side-chain cleavage enzyme, mitochondrialenzyme
GlutethimideGamma-aminobutyric acid receptor subunit alpha-1target
GlutethimideGABA(A) Receptortarget
BarbitalGamma-aminobutyric acid receptor subunit alpha-1target
BarbitalGamma-aminobutyric acid receptor subunit alpha-2target
BarbitalGamma-aminobutyric acid receptor subunit alpha-3target
BarbitalGamma-aminobutyric acid receptor subunit alpha-4target
BarbitalGamma-aminobutyric acid receptor subunit alpha-5target
BarbitalGamma-aminobutyric acid receptor subunit alpha-6target
BarbitalNeuronal acetylcholine receptor subunit alpha-4target
BarbitalNeuronal acetylcholine receptor subunit alpha-7target
BarbitalGlutamate receptor 2target
BarbitalGlutamate receptor ionotropic, kainate 2target
BarbitalCytochrome P450 3A4enzyme
BarbitalCytochrome P450 2C19enzyme
QuazepamCytochrome P450 2C19enzyme
QuazepamCytochrome P450 2C9enzyme
QuazepamCytochrome P450 3A4enzyme
QuazepamGABA(A) Receptortarget
QuazepamCytochrome P450 2B6enzyme
QuazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
NitrazepamSodium channel protein type 1 subunit alphatarget
NitrazepamCytochrome P450 3A4enzyme
NitrazepamCytochrome P450 2E1enzyme
NitrazepamGABA(A) Receptortarget
NitrazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
MethaqualoneCytochrome P450 3A4enzyme
ClomethiazoleGamma-aminobutyric acid receptor subunit alpha-1target
ClomethiazoleCytochrome P450 2A6enzyme
ClomethiazoleCytochrome P450 2B6enzyme
ClomethiazoleCytochrome P450 2C19enzyme
ClomethiazoleCytochrome P450 3A4enzyme
BrotizolamCytochrome P450 3A4enzyme
BrotizolamGABA(A) Receptortarget
BrotizolamGABA(A) Receptor Benzodiazepine Binding Sitetarget
ParaldehydeAldehyde dehydrogenase, mitochondrialenzyme
MethylphenobarbitalGamma-aminobutyric acid receptor subunit alpha-1target
MethylphenobarbitalCytochrome P450 2C19enzyme
MethylphenobarbitalCytochrome P450 2B6enzyme
MethylphenobarbitalGamma-aminobutyric acid receptor subunit alpha-2target
MethylphenobarbitalGamma-aminobutyric acid receptor subunit alpha-3target
MethylphenobarbitalGamma-aminobutyric acid receptor subunit alpha-4target
MethylphenobarbitalGamma-aminobutyric acid receptor subunit alpha-5target
MethylphenobarbitalGamma-aminobutyric acid receptor subunit alpha-6target
MethylphenobarbitalNeuronal acetylcholine receptor subunit alpha-4target
MethylphenobarbitalNeuronal acetylcholine receptor subunit alpha-7target
MethylphenobarbitalGlutamate receptor 2target
MethylphenobarbitalGlutamate receptor ionotropic, kainate 2target
MethylphenobarbitalNuclear receptor subfamily 1 group I member 2target
ThiamylalGamma-aminobutyric acid receptor subunit alpha-1target
ThiamylalATP-sensitive inward rectifier potassium channel 8target
ThiamylalATP-sensitive inward rectifier potassium channel 11target
ThiamylalCytochrome P450 2C9enzyme
ThiamylalCytochrome P450 3A4enzyme
ThiamylalCytochrome P450 2E1enzyme
PhenobarbitalGamma-aminobutyric acid receptor subunit alpha-1target
PhenobarbitalCytochrome P450 2C19enzyme
PhenobarbitalCytochrome P450 2C9enzyme
PhenobarbitalCytochrome P450 2B6enzyme
PhenobarbitalCytochrome P450 2C8enzyme
PhenobarbitalCytochrome P450 1A2enzyme
PhenobarbitalCytochrome P450 3A4enzyme
PhenobarbitalCanalicular multispecific organic anion transporter 2transporter
PhenobarbitalBile salt export pumptransporter
PhenobarbitalP-glycoprotein 1transporter
PhenobarbitalMultidrug resistance-associated protein 1transporter
PhenobarbitalSolute carrier organic anion transporter family member 2A1transporter
PhenobarbitalCanalicular multispecific organic anion transporter 1transporter
PhenobarbitalNeuronal acetylcholine receptor subunit alpha-4target
PhenobarbitalNeuronal acetylcholine receptor subunit alpha-7target
PhenobarbitalGlutamate receptor 2target
PhenobarbitalGlutamate receptor ionotropic, kainate 2target
PhenobarbitalCytochrome P450 2A6enzyme
PhenobarbitalCytochrome P450 2E1enzyme
PhenobarbitalCytochrome P450 3A5enzyme
PhenobarbitalCytochrome P450 1A1enzyme
PhenobarbitalCytochrome P450 2C18enzyme
PhenobarbitalCytochrome P450 3A7enzyme
PhenobarbitalCytochrome P450 4B1enzyme
PhenobarbitalNMDA receptortarget
PhenobarbitalNuclear receptor subfamily 1 group I member 2target
PhenobarbitalUDP-glucuronosyltransferase 1-1enzyme
PhenobarbitalUDP-glucuronosyltransferase 2B7enzyme
LormetazepamGABA(A) Receptortarget
LormetazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
ButalbitalGamma-aminobutyric acid receptor subunit alpha-1target
ButalbitalGamma-aminobutyric acid receptor subunit alpha-2target
ButalbitalGamma-aminobutyric acid receptor subunit alpha-3target
ButalbitalGamma-aminobutyric acid receptor subunit alpha-4target
ButalbitalGamma-aminobutyric acid receptor subunit alpha-5target
ButalbitalGamma-aminobutyric acid receptor subunit alpha-6target
ButalbitalNeuronal acetylcholine receptor subunit alpha-4target
ButalbitalNeuronal acetylcholine receptor subunit alpha-7target
ButalbitalGlutamate receptor 2target
ButalbitalGlutamate receptor ionotropic, kainate 2target
ButalbitalGABA(A) Receptortarget
LorazepamUDP-glucuronosyltransferase 2B15enzyme
LorazepamGABA(A) Receptortarget
LorazepamCytochrome P450 3A4enzyme
LorazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
ButabarbitalGlutamate receptor 2target
ButabarbitalGlutamate receptor ionotropic, kainate 2target
ButabarbitalGABA(A) Receptortarget
ButabarbitalSolute carrier family 2, facilitated glucose transporter member 1transporter
ButabarbitalNeuronal Acetylcholine (nACh) Receptor Subunitstarget
ButabarbitalGlutamate receptor 1target
ButabarbitalGlutamate receptor 3target
ButabarbitalGlutamate receptor 4target
ButabarbitalGlutamate receptor ionotropic, kainate 1target
ButabarbitalGlutamate receptor ionotropic, kainate 3target
ButabarbitalGlutamate receptor ionotropic, kainate 4target
ButabarbitalGlutamate receptor ionotropic, kainate 5target
ButabarbitalSerum albumincarrier
EtomidateGamma-aminobutyric acid receptor subunit alpha-1target
EtomidateAlpha-2B adrenergic receptortarget
EtomidateSolute carrier family 2, facilitated glucose transporter member 1carrier
EtomidateCytochrome P450 11B1, mitochondrialenzyme
EtomidateCytochrome P450 11B2, mitochondrialenzyme
EtomidateGABA(A) Receptortarget
MeprobamateGamma-aminobutyric acid receptor subunit alpha-1target
MeprobamateGamma-aminobutyric acid receptor subunit alpha-2target
MeprobamateGamma-aminobutyric acid receptor subunit alpha-3target
MeprobamateGamma-aminobutyric acid receptor subunit alpha-4target
MeprobamateGamma-aminobutyric acid receptor subunit alpha-5target
MeprobamateGamma-aminobutyric acid receptor subunit alpha-6target
MeprobamateGABA(A) Receptortarget
ChlordiazepoxideGABA(A) Receptortarget
ChlordiazepoxideGABA(A) Receptor Benzodiazepine Binding Sitetarget
PropofolCytochrome P450 2B6enzyme
PropofolUDP-glucuronosyltransferase 1-1enzyme
PropofolUDP-glucuronosyltransferase 1-9enzyme
PropofolGamma-aminobutyric acid receptor subunit beta-2target
PropofolGamma-aminobutyric acid receptor subunit beta-3target
PropofolSerum albumincarrier
PropofolSodium channel protein type 4 subunit alphatarget
PropofolSodium channel protein type 2 subunit alphatarget
PropofolFatty-acid amide hydrolase 1enzyme
PropofolCytochrome P450 2C9enzyme
PropofolUDP-glucuronosyltransferase 1-8enzyme
PropofolCytochrome P450 2E1enzyme
PropofolCytochrome P450 1B1enzyme
PropofolCytochrome P450 1A1enzyme
PropofolCytochrome P450 1A2enzyme
PropofolCytochrome P450 2C18enzyme
PropofolCytochrome P450 2C19enzyme
PropofolCytochrome P450 2C8enzyme
PropofolUDP-glucuronosyltransferase 1-6enzyme
PropofolGABA(A) Receptortarget
PropofolP-glycoprotein 1transporter
DiazepamCytochrome P450 3A4enzyme
DiazepamSerum albumincarrier
DiazepamCytochrome P450 2C9enzyme
DiazepamCytochrome P450 2C19enzyme
DiazepamCytochrome P450 3A5enzyme
DiazepamCytochrome P450 3A7enzyme
DiazepamP-glycoprotein 1transporter
DiazepamCytochrome P450 2B6enzyme
DiazepamProstaglandin G/H synthase 1enzyme
DiazepamCytochrome P450 2C18enzyme
DiazepamCytochrome P450 2C8enzyme
DiazepamCytochrome P450 2E1enzyme
DiazepamGABA(A) Receptortarget
DiazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
OxazepamUDP-glucuronosyltransferase 2B15enzyme
OxazepamUDP-glucuronosyltransferase 2B7enzyme
OxazepamUDP-glucuronosyltransferase 1-9enzyme
OxazepamGABA(A) Receptortarget
OxazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
OxazepamSerum albumincarrier
RemifentanilMu-type opioid receptortarget
RemifentanilDelta-type opioid receptortarget
RemifentanilKappa-type opioid receptortarget
DiphenhydramineHistamine H1 receptortarget
DiphenhydramineCytochrome P450 2D6enzyme
DiphenhydramineCytochrome P450 2C9enzyme
DiphenhydramineCytochrome P450 2C19enzyme
DiphenhydramineSolute carrier family 22 member 2transporter
DiphenhydramineSolute carrier family 22 member 5transporter
DiphenhydramineProstaglandin G/H synthase 1enzyme
DiphenhydramineMuscarinic acetylcholine receptor M2target
FospropofolGamma-aminobutyric acid receptor subunit beta-2target
FospropofolGamma-aminobutyric acid receptor subunit beta-3target
FospropofolAlkaline phosphatase, tissue-nonspecific isozymeenzyme
FospropofolSerum albumincarrier
XylazineAlpha-2 adrenergic receptorstarget
MedazepamGABA(A) Receptortarget
MedazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
TalbutalGamma-aminobutyric acid receptor subunit alpha-1target
TalbutalGamma-aminobutyric acid receptor subunit alpha-2target
TalbutalGamma-aminobutyric acid receptor subunit alpha-3target
TalbutalGamma-aminobutyric acid receptor subunit alpha-4target
TalbutalGamma-aminobutyric acid receptor subunit alpha-5target
TalbutalGamma-aminobutyric acid receptor subunit alpha-6target
TalbutalNeuronal acetylcholine receptor subunit alpha-4target
TalbutalNeuronal acetylcholine receptor subunit alpha-7target
TalbutalGlutamate receptor 2target
TalbutalGlutamate receptor ionotropic, kainate 2target
TalbutalGABA(A) Receptortarget
MethohexitalGamma-aminobutyric acid receptor subunit alpha-1target
MethohexitalCytochrome P450 2C19enzyme
Propiomazine5-hydroxytryptamine receptor 2Atarget
PropiomazineDopamine D2 receptortarget
PropiomazineHistamine H1 receptortarget
Propiomazine5-hydroxytryptamine receptor 2Ctarget
PropiomazineAlpha-1A adrenergic receptortarget
PropiomazineMuscarinic acetylcholine receptortarget
PrimidoneGamma-aminobutyric acid receptor subunit alpha-1target
PrimidoneCytochrome P450 2C19enzyme
PrimidoneCytochrome P450 2C9enzyme
PrimidoneCytochrome P450 3A4enzyme
PrimidoneGamma-aminobutyric acid receptor subunit alpha-2target
PrimidoneGamma-aminobutyric acid receptor subunit alpha-3target
PrimidoneGamma-aminobutyric acid receptor subunit alpha-4target
PrimidoneGamma-aminobutyric acid receptor subunit alpha-5target
PrimidoneGamma-aminobutyric acid receptor subunit alpha-6target
PrimidoneNeuronal acetylcholine receptor subunit alpha-4target
PrimidoneNeuronal acetylcholine receptor subunit alpha-7target
PrimidoneGlutamate receptor 2target
PrimidoneGlutamate receptor ionotropic, kainate 2target
PrimidoneGABA(A) Receptortarget
PrimidoneTransient receptor potential cation channel subfamily M member 3transporter
PrimidoneCytochrome P450 2E1enzyme
PrimidoneCytochrome P450 1A2enzyme
PrimidoneUDP-glucuronosyltransferases (UGTs)enzyme
TriazolamCytochrome P450 3A4enzyme
TriazolamCytochrome P450 3A5enzyme
TriazolamCytochrome P450 3A7enzyme
TriazolamCytochrome P450 2C8enzyme
TriazolamGABA(A) Receptor Benzodiazepine Binding Sitetarget
TriazolamGABA(A) Receptortarget
MethyprylonGamma-aminobutyric acid receptor subunit alpha-1target
MethyprylonGABA(A) Receptortarget
EstazolamCytochrome P450 3A4enzyme
EstazolamGABA(A) Receptortarget
EstazolamGABA(A) Receptor Benzodiazepine Binding Sitetarget
AprobarbitalGamma-aminobutyric acid receptor subunit alpha-1target
AprobarbitalGamma-aminobutyric acid receptor subunit alpha-2target
AprobarbitalGamma-aminobutyric acid receptor subunit alpha-3target
AprobarbitalGamma-aminobutyric acid receptor subunit alpha-4target
AprobarbitalGamma-aminobutyric acid receptor subunit alpha-5target
AprobarbitalGamma-aminobutyric acid receptor subunit alpha-6target
AprobarbitalNeuronal acetylcholine receptor subunit alpha-4target
AprobarbitalNeuronal acetylcholine receptor subunit alpha-7target
AprobarbitalGlutamate receptor 2target
AprobarbitalGlutamate receptor ionotropic, kainate 2target
AprobarbitalCytochrome P450 3A4enzyme
HeptabarbitalGamma-aminobutyric acid receptor subunit alpha-1target
HeptabarbitalGamma-aminobutyric acid receptor subunit alpha-2target
HeptabarbitalGamma-aminobutyric acid receptor subunit alpha-3target
HeptabarbitalGamma-aminobutyric acid receptor subunit alpha-4target
HeptabarbitalGamma-aminobutyric acid receptor subunit alpha-5target
HeptabarbitalGamma-aminobutyric acid receptor subunit alpha-6target
HeptabarbitalNeuronal acetylcholine receptor subunit alpha-4target
HeptabarbitalNeuronal acetylcholine receptor subunit alpha-7target
HeptabarbitalGlutamate receptor 2target
HeptabarbitalGlutamate receptor ionotropic, kainate 2target
FlunitrazepamCytochrome P450 2C19enzyme
FlunitrazepamUDP-glucuronosyltransferase 2B7enzyme
FlunitrazepamCytochrome P450 2A6enzyme
FlunitrazepamCytochrome P450 2B6enzyme
FlunitrazepamCytochrome P450 2C9enzyme
FlunitrazepamCytochrome P450 3A4enzyme
FlunitrazepamCytochrome P450 2E1enzyme
FlunitrazepamUDP-glucuronosyltransferase 1-1enzyme
FlunitrazepamUDP-glucuronosyltransferase 1-3enzyme
FlunitrazepamGABA(A) Receptortarget
FlunitrazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
CinolazepamGABA(A) Receptortarget
CinolazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
LoprazolamGABA(A) Receptortarget
LoprazolamGABA(A) Receptor Benzodiazepine Binding Sitetarget
DoxefazepamGABA(A) Receptortarget
DoxefazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
BromazepamCytochrome P450 1A2enzyme
BromazepamCytochrome P450 2C19enzyme
BromazepamCytochrome P450 2E1enzyme
BromazepamGABA(A) Receptortarget
BromazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
EtizolamCytochrome P450 3A4enzyme
EtizolamCytochrome P450 2C18enzyme
EtizolamCytochrome P450 2C19enzyme
EtizolamPlatelet-activating factor receptortarget
EtizolamGABA(A) Receptortarget
EtizolamGABA(A) Receptor Benzodiazepine Binding Sitetarget
AlprazolamCytochrome P450 3A4enzyme
AlprazolamCytochrome P450 2C9enzyme
AlprazolamCytochrome P450 3A5enzyme
AlprazolamCytochrome P450 3A7enzyme
AlprazolamGABA(A) Receptortarget
AlprazolamSerum albumincarrier
Alprazolamalpha1-acid glycoproteincarrier
AlprazolamGABA(A) Receptor Benzodiazepine Binding Sitetarget
MelatoninAcetylserotonin O-methyltransferasetarget
MelatoninMelatonin receptor type 1Atarget
MelatoninMelatonin receptor type 1Btarget
MelatoninNuclear receptor ROR-betatarget
MelatoninCalmodulintarget
MelatoninCalreticulintarget
MelatoninRibosyldihydronicotinamide dehydrogenase [quinone]target
MelatoninMyeloperoxidasetarget
MelatoninEstrogen receptor alphatarget
MelatoninEosinophil peroxidasetarget
MelatoninCytochrome P450 1A1enzyme
MelatoninCytochrome P450 1A2enzyme
MelatoninCytochrome P450 2C19enzyme
MelatoninCytochrome P450 2C9enzyme
MelatoninAcetylserotonin O-methyltransferaseenzyme
MelatoninIndoleamine 2,3-dioxygenase 1enzyme
MelatoninMyeloperoxidaseenzyme
MelatoninCytochrome P450 1B1enzyme
MelatoninSolute carrier family 22 member 8transporter
MelatoninCytochrome P450 19A1enzyme
ScopolamineMuscarinic acetylcholine receptor M1target
ScopolamineSucrase-isomaltase, intestinaltarget
ScopolamineMuscarinic acetylcholine receptor M2target
ScopolamineMuscarinic acetylcholine receptor M3target
ScopolamineMuscarinic acetylcholine receptor M4target
ScopolamineMuscarinic acetylcholine receptor M5target
ScopolamineP-glycoprotein 1transporter
ScopolamineNeuronal acetylcholine receptor subunit alpha-4target
ScopolamineNeuronal acetylcholine receptor subunit beta-2target
RamelteonMelatonin receptor type 1Btarget
RamelteonMelatonin receptor type 1Atarget
RamelteonCytochrome P450 1A2enzyme
RamelteonCytochrome P450 2C19enzyme
RamelteonCytochrome P450 3A4enzyme
RamelteonCytochrome P450 2C9enzyme
TasimelteonMelatonin receptor type 1Atarget
TasimelteonMelatonin receptor type 1Btarget
TasimelteonCytochrome P450 3A4enzyme
TasimelteonCytochrome P450 1A2enzyme
PagocloneGamma-aminobutyric acid receptor subunit alpha-2target
PagocloneGamma-aminobutyric acid receptor subunit alpha-3target
BentazepamGABA(A) Receptortarget
BentazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
S-EthylisothioureaNitric oxide synthase oxygenasetarget
S-EthylisothioureaNitric oxide synthase, inducibletarget
S-EthylisothioureaNitric oxide synthase, endothelialtarget
SuvorexantOrexin receptor type 1target
SuvorexantOrexin receptor type 2target
SuvorexantCytochrome P450 3A4enzyme
SuvorexantP-glycoprotein 1transporter
DoxepinSodium-dependent serotonin transportertarget
DoxepinSodium-dependent noradrenaline transportertarget
DoxepinHistamine H1 receptortarget
DoxepinHistamine H2 receptortarget
DoxepinCytochrome P450 2D6enzyme
DoxepinMuscarinic acetylcholine receptor M1target
DoxepinMuscarinic acetylcholine receptor M2target
DoxepinMuscarinic acetylcholine receptor M3target
DoxepinMuscarinic acetylcholine receptor M4target
DoxepinMuscarinic acetylcholine receptor M5target
DoxepinAlpha-1A adrenergic receptortarget
Doxepin5-hydroxytryptamine receptor 1Atarget
Doxepin5-hydroxytryptamine receptor 2Atarget
DoxepinCytochrome P450 2C19enzyme
DoxepinCytochrome P450 2C9enzyme
DoxepinCytochrome P450 1A2enzyme
DoxepinP-glycoprotein 1transporter
Doxepin5-hydroxytryptamine receptor 2Btarget
Doxepin5-hydroxytryptamine receptor 2Ctarget
DoxepinAlpha-1B adrenergic receptortarget
DoxepinAlpha-1D adrenergic receptortarget
DoxepinCytochrome P450 3A4enzyme
Doxepin5-hydroxytryptamine receptor 6target
DoxepinHistamine H4 receptortarget
DoxepinPotassium voltage-gated channel subfamily H member 2target
DoxepinSerum albumincarrier
DoxepinAlpha-1-acid glycoprotein 1carrier
MepyramineCytochrome P450 2D6enzyme
MepyramineHistamine H1 receptortarget
MepyramineSolute carrier family 22 member 4transporter
MepyramineSolute carrier family 22 member 5transporter