Pheniprazine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Pheniprazine
Accession Number
DB09250
Type
Small Molecule
Groups
Withdrawn
Description

Pheniprazine is an irreversible and nonselective monoamine oxidase inhibitor (MAOI) of the hydrazine chemical class that was used as an antidepressant in the 1960s. It was also used in the treatment of angina pectoris and schizophrenia. Pheniprazine has been largely discontinued due to toxicity concerns such as jaundice, amblyopia, and optic neuritis.

Structure
Thumb
Synonyms
Not Available
Product Ingredients
IngredientUNIICASInChI Key
Pheniprazine hydrochloride5B3OM8452C66-05-7HXCTUSBYMZQLKB-UHFFFAOYSA-N
International/Other Brands
Catron / Cavodil
Categories
UNII
37VKD7067M
CAS number
55-52-7
Weight
Average: 150.225
Monoisotopic: 150.115698459
Chemical Formula
C9H14N2
InChI Key
VXTWEDPZMSVFEF-UHFFFAOYSA-N
InChI
InChI=1S/C9H14N2/c1-8(11-10)7-9-5-3-2-4-6-9/h2-6,8,11H,7,10H2,1H3
IUPAC Name
(1-phenylpropan-2-yl)hydrazine
SMILES
CC(CC1=CC=CC=C1)NN

Pharmacology

Indication

For the treatment of depression, schizophrenia, and angina pectoris.

Structured Indications
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
2,5-Dimethoxy-4-ethylamphetaminePheniprazine may increase the hypertensive activities of 2,5-Dimethoxy-4-ethylamphetamine.Experimental, Illicit
3,4-MethylenedioxyamphetaminePheniprazine may increase the hypertensive activities of 3,4-Methylenedioxyamphetamine.Experimental, Illicit
4-Bromo-2,5-dimethoxyamphetaminePheniprazine may increase the hypertensive activities of 4-Bromo-2,5-dimethoxyamphetamine.Experimental, Illicit
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline may increase the hypertensive activities of Pheniprazine.Experimental
AcarbosePheniprazine may increase the hypoglycemic activities of Acarbose.Approved, Investigational
AcebutololPheniprazine may increase the hypotensive activities of Acebutolol.Approved
AlaproclateThe risk or severity of adverse effects can be increased when Alaproclate is combined with Pheniprazine.Experimental
AlbiglutidePheniprazine may increase the hypoglycemic activities of Albiglutide.Approved
AlfentanilAlfentanil may increase the serotonergic activities of Pheniprazine.Approved, Illicit
AliskirenPheniprazine may increase the hypotensive activities of Aliskiren.Approved, Investigational
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Pheniprazine.Approved, Investigational
AlogliptinPheniprazine may increase the hypoglycemic activities of Alogliptin.Approved
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Pheniprazine.Experimental, Illicit
AlphaprodineThe risk or severity of adverse effects can be increased when Alphaprodine is combined with Pheniprazine.Illicit
AlprenololPheniprazine may increase the hypotensive activities of Alprenolol.Approved, Withdrawn
AltretamineAltretamine may increase the orthostatic hypotensive activities of Pheniprazine.Approved
AmbrisentanPheniprazine may increase the hypotensive activities of Ambrisentan.Approved, Investigational
AmineptinePheniprazine may increase the serotonergic activities of Amineptine.Illicit, Withdrawn
AmitriptylinePheniprazine may increase the serotonergic activities of Amitriptyline.Approved
AmlodipinePheniprazine may increase the hypotensive activities of Amlodipine.Approved
AmoxapineThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Amoxapine.Approved
AmphetaminePheniprazine may increase the hypertensive activities of Amphetamine.Approved, Illicit
ApomorphineThe metabolism of Apomorphine can be decreased when combined with Pheniprazine.Approved, Investigational
ApraclonidineThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Apraclonidine.Approved
ArbutamineThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Arbutamine.Approved
ArformoterolThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Arformoterol.Approved, Investigational
AtenololPheniprazine may increase the hypotensive activities of Atenolol.Approved
AtomoxetinePheniprazine may increase the central neurotoxic activities of Atomoxetine.Approved
AtropinePheniprazine may increase the hypertensive activities of Atropine.Approved, Vet Approved
BambuterolThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Bambuterol.Approved, Investigational
BenazeprilPheniprazine may increase the hypotensive activities of Benazepril.Approved, Investigational
BendroflumethiazidePheniprazine may increase the hypotensive activities of Bendroflumethiazide.Approved
BenmoxinBenmoxin may increase the hypertensive activities of Pheniprazine.Withdrawn
BenzphetaminePheniprazine may increase the hypertensive activities of Benzphetamine.Approved, Illicit
BepridilPheniprazine may increase the hypotensive activities of Bepridil.Approved, Withdrawn
BetahistineThe serum concentration of Betahistine can be increased when it is combined with Pheniprazine.Approved
BetaxololPheniprazine may increase the hypotensive activities of Betaxolol.Approved
BethanidinePheniprazine may increase the hypotensive activities of Bethanidine.Approved
BezafibrateThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Bezafibrate.Approved
BietaserpinePheniprazine may increase the hypotensive activities of Bietaserpine.Experimental
BimatoprostPheniprazine may increase the hypotensive activities of Bimatoprost.Approved, Investigational
BisoprololPheniprazine may increase the hypotensive activities of Bisoprolol.Approved
BosentanPheniprazine may increase the hypotensive activities of Bosentan.Approved, Investigational
BQ-123Pheniprazine may increase the hypotensive activities of BQ-123.Investigational
BretyliumPheniprazine may increase the hypotensive activities of Bretylium.Approved
BrimonidineThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Brimonidine.Approved
BrofaromineBrofaromine may increase the hypertensive activities of Pheniprazine.Experimental
BromocriptinePheniprazine may increase the hypoglycemic activities of Bromocriptine.Approved, Investigational
BupranololPheniprazine may increase the hypotensive activities of Bupranolol.Approved
BuprenorphineThe risk or severity of adverse effects can be increased when Buprenorphine is combined with Pheniprazine.Approved, Illicit, Investigational, Vet Approved
BuprenorphineThe risk or severity of adverse effects can be increased when Buprenorphine is combined with Pheniprazine.Approved, Illicit, Investigational, Vet Approved
BupropionPheniprazine may increase the hypertensive activities of Bupropion.Approved
BupropionThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Bupropion.Approved
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Pheniprazine.Approved, Investigational
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Pheniprazine.Approved, Illicit, Vet Approved
CabergolineThe metabolism of Cabergoline can be decreased when combined with Pheniprazine.Approved
CadralazinePheniprazine may increase the hypotensive activities of Cadralazine.Experimental
CafedrinePheniprazine may increase the hypotensive activities of Cafedrine.Investigational
CanagliflozinPheniprazine may increase the hypoglycemic activities of Canagliflozin.Approved
CandesartanPheniprazine may increase the hypotensive activities of Candesartan.Experimental
Candesartan cilexetilPheniprazine may increase the hypotensive activities of Candesartan cilexetil.Approved
CandoxatrilPheniprazine may increase the hypotensive activities of Candoxatril.Experimental
CaptoprilPheniprazine may increase the hypotensive activities of Captopril.Approved
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Pheniprazine.Approved, Investigational
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Pheniprazine.Approved, Investigational
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Pheniprazine.Illicit, Investigational, Vet Approved
CaroxazonePheniprazine may increase the hypertensive activities of Caroxazone.Withdrawn
CarteololPheniprazine may increase the hypotensive activities of Carteolol.Approved
CarvedilolPheniprazine may increase the hypotensive activities of Carvedilol.Approved, Investigational
CeliprololPheniprazine may increase the hypotensive activities of Celiprolol.Approved, Investigational
ChlorothiazidePheniprazine may increase the hypotensive activities of Chlorothiazide.Approved, Vet Approved
ChlorphenterminePheniprazine may increase the hypertensive activities of Chlorphentermine.Illicit, Withdrawn
ChlorpropamidePheniprazine may increase the hypoglycemic activities of Chlorpropamide.Approved
ChlorthalidonePheniprazine may increase the hypotensive activities of Chlorthalidone.Approved
CicletaninePheniprazine may increase the hypotensive activities of Cicletanine.Investigational
CilazaprilPheniprazine may increase the hypotensive activities of Cilazapril.Approved
CirazolinePheniprazine may increase the hypertensive activities of Cirazoline.Experimental
CitalopramPheniprazine may increase the serotonergic activities of Citalopram.Approved
ClemastinePheniprazine may increase the anticholinergic activities of Clemastine.Approved
ClenbuterolThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Clenbuterol.Approved, Investigational, Vet Approved
ClomipraminePheniprazine may increase the serotonergic activities of Clomipramine.Approved, Vet Approved
ClonidinePheniprazine may increase the hypotensive activities of Clonidine.Approved
CloranololPheniprazine may increase the hypotensive activities of Cloranolol.Experimental
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Pheniprazine.Approved, Illicit
CryptenaminePheniprazine may increase the hypotensive activities of Cryptenamine.Approved
CyclobenzaprineCyclobenzaprine may increase the serotonergic activities of Pheniprazine.Approved
CyclobenzaprineCyclobenzaprine may increase the serotonergic activities of Pheniprazine.Approved
CyclopenthiazidePheniprazine may increase the hypotensive activities of Cyclopenthiazide.Experimental
CyclothiazidePheniprazine may increase the hypotensive activities of Cyclothiazide.Approved
CyproheptadinePheniprazine may increase the anticholinergic activities of Cyproheptadine.Approved
DapagliflozinPheniprazine may increase the hypoglycemic activities of Dapagliflozin.Approved
DapoxetinePheniprazine may increase the serotonergic activities of Dapoxetine.Investigational
DebrisoquinPheniprazine may increase the hypotensive activities of Debrisoquin.Approved, Investigational
DelaprilPheniprazine may increase the hypotensive activities of Delapril.Experimental
DeserpidinePheniprazine may increase the hypotensive activities of Deserpidine.Approved
DesipraminePheniprazine may increase the serotonergic activities of Desipramine.Approved
DesvenlafaxinePheniprazine may increase the serotonergic activities of Desvenlafaxine.Approved
DexmethylphenidatePheniprazine may increase the hypertensive activities of Dexmethylphenidate.Approved
DextroamphetaminePheniprazine may increase the hypertensive activities of Dextroamphetamine.Approved, Illicit
DextromethorphanPheniprazine may increase the serotonergic activities of Dextromethorphan.Approved
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Pheniprazine.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Pheniprazine.Approved, Illicit, Investigational, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Pheniprazine.Approved, Investigational
DiazoxidePheniprazine may increase the hypotensive activities of Diazoxide.Approved
DibenzepinPheniprazine may increase the serotonergic activities of Dibenzepin.Experimental
diethylnorsperminePheniprazine may increase the hypotensive activities of diethylnorspermine.Investigational
DiethylpropionPheniprazine may increase the hypertensive activities of Diethylpropion.Approved, Illicit
DihydralazinePheniprazine may increase the hypotensive activities of Dihydralazine.Investigational
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Pheniprazine.Approved, Illicit
DihydroergotamineThe metabolism of Dihydroergotamine can be decreased when combined with Pheniprazine.Approved
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Pheniprazine.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Pheniprazine.Experimental, Illicit
DiltiazemPheniprazine may increase the hypotensive activities of Diltiazem.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Pheniprazine.Approved, Illicit
DipivefrinThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Dipivefrin.Approved
DisopyramidePheniprazine may increase the hypoglycemic activities of Disopyramide.Approved
DobutamineThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Dobutamine.Approved
DomperidoneThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Domperidone.Approved, Investigational, Vet Approved
DorzolamidePheniprazine may increase the hypotensive activities of Dorzolamide.Approved
DosulepinPheniprazine may increase the serotonergic activities of Dosulepin.Approved
DoxapramPheniprazine may increase the hypertensive activities of Doxapram.Approved, Vet Approved
DoxazosinPheniprazine may increase the hypotensive activities of Doxazosin.Approved
DoxepinPheniprazine may increase the serotonergic activities of Doxepin.Approved
DoxylaminePheniprazine may increase the anticholinergic activities of Doxylamine.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when DPDPE is combined with Pheniprazine.Experimental
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Pheniprazine.Experimental, Illicit
DroxidopaThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Droxidopa.Approved, Investigational
DulaglutidePheniprazine may increase the hypoglycemic activities of Dulaglutide.Approved
DuloxetinePheniprazine may increase the serotonergic activities of Duloxetine.Approved
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Pheniprazine.Experimental, Illicit
EfonidipinePheniprazine may increase the hypotensive activities of Efonidipine.Approved, Investigational
EletriptanThe metabolism of Eletriptan can be decreased when combined with Pheniprazine.Approved, Investigational
EmpagliflozinPheniprazine may increase the hypoglycemic activities of Empagliflozin.Approved
EnalaprilPheniprazine may increase the hypotensive activities of Enalapril.Approved, Vet Approved
EnalaprilatPheniprazine may increase the hypotensive activities of Enalaprilat.Approved
EndralazinePheniprazine may increase the hypotensive activities of Endralazine.Experimental
EntacaponeThe risk or severity of adverse effects can be increased when Entacapone is combined with Pheniprazine.Approved, Investigational
EpanololPheniprazine may increase the hypotensive activities of Epanolol.Experimental
EphedraThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Ephedra.Approved, Nutraceutical, Withdrawn
EpinephrinePheniprazine may increase the hypertensive activities of Epinephrine.Approved, Vet Approved
EpoprostenolPheniprazine may increase the hypotensive activities of Epoprostenol.Approved
EprosartanPheniprazine may increase the hypotensive activities of Eprosartan.Approved
ErgotaminePheniprazine may increase the hypertensive activities of Ergotamine.Approved
EscitalopramPheniprazine may increase the serotonergic activities of Escitalopram.Approved, Investigational
EsmirtazapinePheniprazine may increase the serotonergic activities of Esmirtazapine.Investigational
EthanolThe risk or severity of adverse effects can be increased when Ethanol is combined with Pheniprazine.Approved
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Pheniprazine.Approved, Illicit
EtoperidonePheniprazine may increase the serotonergic activities of Etoperidone.Withdrawn
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Pheniprazine.Illicit, Vet Approved
ExenatidePheniprazine may increase the hypoglycemic activities of Exenatide.Approved, Investigational
FelodipinePheniprazine may increase the hypotensive activities of Felodipine.Approved, Investigational
FenfluramineThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Fenfluramine.Illicit, Investigational, Withdrawn
FenoldopamPheniprazine may increase the hypotensive activities of Fenoldopam.Approved
FenoterolThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Fenoterol.Approved, Investigational
FentanylFentanyl may increase the serotonergic activities of Pheniprazine.Approved, Illicit, Investigational, Vet Approved
Ferulic acidPheniprazine may increase the hypotensive activities of Ferulic acid.Experimental
FluoxetinePheniprazine may increase the serotonergic activities of Fluoxetine.Approved, Vet Approved
FluvoxaminePheniprazine may increase the serotonergic activities of Fluvoxamine.Approved, Investigational
FormoterolThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Formoterol.Approved, Investigational
FosinoprilPheniprazine may increase the hypotensive activities of Fosinopril.Approved
FrovatriptanThe metabolism of Frovatriptan can be decreased when combined with Pheniprazine.Approved, Investigational
FurazolidoneFurazolidone may increase the hypertensive activities of Pheniprazine.Approved, Investigational, Vet Approved
GepefrineThe risk or severity of adverse effects can be increased when Gepefrine is combined with Pheniprazine.Experimental
GliclazidePheniprazine may increase the hypoglycemic activities of Gliclazide.Approved
GlimepiridePheniprazine may increase the hypoglycemic activities of Glimepiride.Approved
GlipizidePheniprazine may increase the hypoglycemic activities of Glipizide.Approved
GlyburidePheniprazine may increase the hypoglycemic activities of Glyburide.Approved
GuanabenzPheniprazine may increase the hypotensive activities of Guanabenz.Approved, Investigational
GuanadrelPheniprazine may increase the hypotensive activities of Guanadrel.Approved
GuanazodinePheniprazine may increase the hypotensive activities of Guanazodine.Experimental
GuanethidinePheniprazine may increase the hypotensive activities of Guanethidine.Approved
GuanfacinePheniprazine may increase the hypotensive activities of Guanfacine.Approved, Investigational
GuanoclorPheniprazine may increase the hypotensive activities of Guanoclor.Experimental
GuanoxabenzPheniprazine may increase the hypotensive activities of Guanoxabenz.Experimental
GuanoxanPheniprazine may increase the hypotensive activities of Guanoxan.Experimental
HarmalineHarmaline may increase the hypertensive activities of Pheniprazine.Experimental
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Pheniprazine.Approved, Illicit, Investigational
HexamethoniumPheniprazine may increase the hypotensive activities of Hexamethonium.Experimental
HydracarbazineHydracarbazine may increase the hypertensive activities of Pheniprazine.Experimental
HydralazinePheniprazine may increase the hypotensive activities of Hydralazine.Approved
HydrochlorothiazidePheniprazine may increase the hypotensive activities of Hydrochlorothiazide.Approved, Vet Approved
HydrocodoneThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Hydrocodone.Approved, Illicit
HydrocodoneThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Hydrocodone.Approved, Illicit
HydroflumethiazidePheniprazine may increase the hypotensive activities of Hydroflumethiazide.Approved, Investigational
HydromorphoneThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Hydromorphone.Approved, Illicit
HydromorphoneThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Hydromorphone.Approved, Illicit
HydroxyamphetaminePheniprazine may increase the hypertensive activities of Hydroxyamphetamine.Approved
ImidaprilPheniprazine may increase the hypotensive activities of Imidapril.Investigational
ImipraminePheniprazine may increase the serotonergic activities of Imipramine.Approved
IndacaterolThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Indacaterol.Approved
IndalpinePheniprazine may increase the serotonergic activities of Indalpine.Investigational, Withdrawn
IndapamidePheniprazine may increase the hypotensive activities of Indapamide.Approved
IndenololPheniprazine may increase the hypotensive activities of Indenolol.Withdrawn
IndoraminPheniprazine may increase the hypotensive activities of Indoramin.Withdrawn
Insulin AspartPheniprazine may increase the hypoglycemic activities of Insulin Aspart.Approved
Insulin DetemirPheniprazine may increase the hypoglycemic activities of Insulin Detemir.Approved
Insulin GlarginePheniprazine may increase the hypoglycemic activities of Insulin Glargine.Approved
Insulin GlulisinePheniprazine may increase the hypoglycemic activities of Insulin Glulisine.Approved
Insulin HumanPheniprazine may increase the hypoglycemic activities of Insulin Human.Approved, Investigational
Insulin LisproPheniprazine may increase the hypoglycemic activities of Insulin Lispro.Approved
Iofetamine I-123The risk or severity of adverse effects can be increased when Iofetamine I-123 is combined with Pheniprazine.Approved
IprindolePheniprazine may increase the serotonergic activities of Iprindole.Experimental
IproclozideIproclozide may increase the hypertensive activities of Pheniprazine.Withdrawn
IproniazidIproniazid may increase the hypertensive activities of Pheniprazine.Withdrawn
IrbesartanPheniprazine may increase the hypotensive activities of Irbesartan.Approved, Investigational
IsocarboxazidIsocarboxazid may increase the hypertensive activities of Pheniprazine.Approved
IsoetarineThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Isoetarine.Approved
IsomethepteneThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Isometheptene.Approved
IsoprenalineThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Isoprenaline.Approved
IsradipinePheniprazine may increase the hypotensive activities of Isradipine.Approved
KetanserinPheniprazine may increase the hypotensive activities of Ketanserin.Investigational
KetobemidoneThe risk or severity of adverse effects can be increased when Ketobemidone is combined with Pheniprazine.Approved, Investigational
L-TryptophanThe risk or severity of adverse effects can be increased when L-Tryptophan is combined with Pheniprazine.Approved, Nutraceutical, Withdrawn
LabetalolPheniprazine may increase the hypotensive activities of Labetalol.Approved
LacidipinePheniprazine may increase the hypotensive activities of Lacidipine.Approved, Investigational
LatanoprostPheniprazine may increase the hypotensive activities of Latanoprost.Approved, Investigational
LercanidipinePheniprazine may increase the hypotensive activities of Lercanidipine.Approved, Investigational
LevodopaThe risk or severity of adverse effects can be increased when Levodopa is combined with Pheniprazine.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Pheniprazine.Approved, Investigational
LevomilnacipranPheniprazine may increase the serotonergic activities of Levomilnacipran.Approved
LevonordefrinPheniprazine may increase the hypertensive activities of Levonordefrin.Approved
LevonordefrinPheniprazine may increase the hypertensive activities of Levonordefrin.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Pheniprazine.Approved
LevosalbutamolThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Levosalbutamol.Approved
LinezolidThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Linezolid.Approved, Investigational
LinsidominePheniprazine may increase the hypotensive activities of Linsidomine.Experimental
LiraglutidePheniprazine may increase the hypoglycemic activities of Liraglutide.Approved
LisdexamfetaminePheniprazine may increase the hypertensive activities of Lisdexamfetamine.Approved, Investigational
LisinoprilPheniprazine may increase the hypotensive activities of Lisinopril.Approved, Investigational
LisurideThe metabolism of Lisuride can be decreased when combined with Pheniprazine.Approved, Investigational
LithiumThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Lithium.Approved
LofentanilThe risk or severity of adverse effects can be increased when Lofentanil is combined with Pheniprazine.Illicit
LofepraminePheniprazine may increase the serotonergic activities of Lofepramine.Experimental
LofexidinePheniprazine may increase the hypotensive activities of Lofexidine.Approved, Investigational
LosartanPheniprazine may increase the hypotensive activities of Losartan.Approved
MacitentanPheniprazine may increase the hypotensive activities of Macitentan.Approved
ManidipinePheniprazine may increase the hypotensive activities of Manidipine.Approved, Investigational
MaprotilineThe risk or severity of adverse effects can be increased when Maprotiline is combined with Pheniprazine.Approved
MebanazineMebanazine may increase the hypertensive activities of Pheniprazine.Withdrawn
MecamylaminePheniprazine may increase the hypotensive activities of Mecamylamine.Approved
MecaserminPheniprazine may increase the hypoglycemic activities of Mecasermin.Approved, Investigational
MephedronePheniprazine may increase the hypertensive activities of Mephedrone.Investigational
MephenterminePheniprazine may increase the hypertensive activities of Mephentermine.Approved
MeptazinolThe risk or severity of adverse effects can be increased when Meptazinol is combined with Pheniprazine.Experimental
MequitazinePheniprazine may increase the anticholinergic activities of Mequitazine.Approved
MetaraminolPheniprazine may increase the hypertensive activities of Metaraminol.Approved, Investigational
MetforminPheniprazine may increase the hypoglycemic activities of Metformin.Approved
MethadoneThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Methadone.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Pheniprazine.Approved, Illicit
MethamphetaminePheniprazine may increase the hypertensive activities of Methamphetamine.Approved, Illicit
MethoserpidinePheniprazine may increase the hypotensive activities of Methoserpidine.Experimental
MethoxaminePheniprazine may increase the hypertensive activities of Methoxamine.Approved, Investigational
MethoxyphenamineThe risk or severity of adverse effects can be increased when Methoxyphenamine is combined with Pheniprazine.Experimental
MethyldopaThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Methyldopa.Approved
MethylecgonineThe risk or severity of adverse effects can be increased when Methylecgonine is combined with Pheniprazine.Experimental
Methylene bluePheniprazine may increase the serotonergic activities of Methylene blue.Approved, Investigational
MethylphenidatePheniprazine may increase the hypertensive activities of Methylphenidate.Approved, Investigational
MethylphenidatePheniprazine may increase the hypertensive activities of Methylphenidate.Approved, Investigational
MetipranololPheniprazine may increase the hypotensive activities of Metipranolol.Approved
MetolazonePheniprazine may increase the hypotensive activities of Metolazone.Approved
MetoprololPheniprazine may increase the hypotensive activities of Metoprolol.Approved, Investigational
MetyrosinePheniprazine may increase the hypotensive activities of Metyrosine.Approved
MianserinPheniprazine may increase the neurotoxic activities of Mianserin.Approved, Investigational
MibefradilPheniprazine may increase the hypotensive activities of Mibefradil.Investigational, Withdrawn
MidodrinePheniprazine may increase the hypertensive activities of Midodrine.Approved
MidomafetaminePheniprazine may increase the hypertensive activities of Midomafetamine.Experimental, Illicit, Investigational
MifepristonePheniprazine may increase the hypoglycemic activities of Mifepristone.Approved, Investigational
MiglitolPheniprazine may increase the hypoglycemic activities of Miglitol.Approved
MilnacipranPheniprazine may increase the serotonergic activities of Milnacipran.Approved
MinaprineMinaprine may increase the hypertensive activities of Pheniprazine.Approved
MinoxidilPheniprazine may increase the hypotensive activities of Minoxidil.Approved
MirtazapinePheniprazine may increase the central neurotoxic activities of Mirtazapine.Approved
MMDAPheniprazine may increase the hypertensive activities of MMDA.Experimental, Illicit
MoclobemideThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Moclobemide.Approved
MoexiprilPheniprazine may increase the hypotensive activities of Moexipril.Approved
MorphineThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Morphine.Approved, Investigational
MorphineThe therapeutic efficacy of Morphine can be increased when used in combination with Pheniprazine.Approved, Investigational
MoxonidinePheniprazine may increase the hypotensive activities of Moxonidine.Approved, Investigational
MuzoliminePheniprazine may increase the hypotensive activities of Muzolimine.Experimental
NadololPheniprazine may increase the hypotensive activities of Nadolol.Approved
NaftopidilPheniprazine may increase the hypotensive activities of Naftopidil.Investigational
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Pheniprazine.Approved
NaratriptanThe metabolism of Naratriptan can be decreased when combined with Pheniprazine.Approved, Investigational
NateglinidePheniprazine may increase the hypoglycemic activities of Nateglinide.Approved, Investigational
NebivololPheniprazine may increase the hypotensive activities of Nebivolol.Approved, Investigational
NefazodonePheniprazine may increase the serotonergic activities of Nefazodone.Approved, Withdrawn
NialamideNialamide may increase the hypertensive activities of Pheniprazine.Withdrawn
NicardipinePheniprazine may increase the hypotensive activities of Nicardipine.Approved
NicorandilPheniprazine may increase the hypotensive activities of Nicorandil.Approved, Investigational
NiguldipinePheniprazine may increase the hypotensive activities of Niguldipine.Experimental
NilvadipinePheniprazine may increase the hypotensive activities of Nilvadipine.Approved, Investigational
NimodipinePheniprazine may increase the hypotensive activities of Nimodipine.Approved
NisoldipinePheniprazine may increase the hypotensive activities of Nisoldipine.Approved
NitrendipinePheniprazine may increase the hypotensive activities of Nitrendipine.Approved, Investigational
NitroprussidePheniprazine may increase the hypotensive activities of Nitroprusside.Approved
NorepinephrinePheniprazine may increase the hypertensive activities of Norepinephrine.Approved
NormethadoneThe risk or severity of adverse effects can be increased when Normethadone is combined with Pheniprazine.Approved, Illicit
NortriptylinePheniprazine may increase the serotonergic activities of Nortriptyline.Approved
OctamoxinOctamoxin may increase the hypertensive activities of Pheniprazine.Withdrawn
OlanzapineThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Olanzapine.Approved, Investigational
OlmesartanPheniprazine may increase the hypotensive activities of Olmesartan.Approved, Investigational
OlodaterolThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Olodaterol.Approved
OmapatrilatPheniprazine may increase the hypotensive activities of Omapatrilat.Investigational
OpipramolPheniprazine may increase the serotonergic activities of Opipramol.Investigational
OpiumThe risk or severity of adverse effects can be increased when Opium is combined with Pheniprazine.Approved, Illicit
OrciprenalineThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Orciprenaline.Approved
OxprenololPheniprazine may increase the hypotensive activities of Oxprenolol.Approved
OxycodoneThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Pheniprazine.Approved, Investigational, Vet Approved
PargylinePheniprazine may increase the hypotensive activities of Pargyline.Approved
ParoxetinePheniprazine may increase the serotonergic activities of Paroxetine.Approved, Investigational
PenbutololPheniprazine may increase the hypotensive activities of Penbutolol.Approved, Investigational
PentamidinePheniprazine may increase the hypoglycemic activities of Pentamidine.Approved
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Pheniprazine.Approved, Vet Approved
PentoliniumPheniprazine may increase the hypotensive activities of Pentolinium.Approved
PergolideThe metabolism of Pergolide can be decreased when combined with Pheniprazine.Approved, Investigational, Vet Approved, Withdrawn
PerindoprilPheniprazine may increase the hypotensive activities of Perindopril.Approved
PethidinePheniprazine may increase the serotonergic activities of Pethidine.Approved
PhenazocineThe risk or severity of adverse effects can be increased when Phenazocine is combined with Pheniprazine.Experimental
PhenelzinePhenelzine may increase the hypertensive activities of Pheniprazine.Approved
PhenoperidineThe risk or severity of adverse effects can be increased when Phenoperidine is combined with Pheniprazine.Experimental
PhenoxybenzaminePheniprazine may increase the hypotensive activities of Phenoxybenzamine.Approved
PhenoxypropazinePheniprazine may increase the hypertensive activities of Phenoxypropazine.Withdrawn
PhenterminePheniprazine may increase the hypertensive activities of Phentermine.Approved, Illicit
PhentolaminePheniprazine may increase the hypotensive activities of Phentolamine.Approved
PhenylephrinePheniprazine may increase the hypertensive activities of Phenylephrine.Approved
PhenylpropanolamineThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Phenylpropanolamine.Approved, Vet Approved, Withdrawn
PholcodinePholcodine may increase the serotonergic activities of Pheniprazine.Approved, Illicit
PiclozotanThe metabolism of Piclozotan can be decreased when combined with Pheniprazine.Investigational
PinacidilPheniprazine may increase the hypotensive activities of Pinacidil.Withdrawn
PindololPheniprazine may increase the hypotensive activities of Pindolol.Approved
PioglitazonePheniprazine may increase the hypoglycemic activities of Pioglitazone.Approved, Investigational
PirbuterolThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Pirbuterol.Approved
PiritramideThe risk or severity of adverse effects can be increased when Piritramide is combined with Pheniprazine.Investigational
PirlindolePirlindole may increase the hypertensive activities of Pheniprazine.Approved
PivhydrazinePheniprazine may increase the hypertensive activities of Pivhydrazine.Withdrawn
PizotifenPheniprazine may increase the anticholinergic activities of Pizotifen.Approved
Platelet Activating FactorPheniprazine may increase the hypotensive activities of Platelet Activating Factor.Experimental
PolythiazidePheniprazine may increase the hypotensive activities of Polythiazide.Approved
PramlintidePheniprazine may increase the hypoglycemic activities of Pramlintide.Approved, Investigational
PrazosinPheniprazine may increase the hypotensive activities of Prazosin.Approved
ProcarbazineProcarbazine may increase the hypertensive activities of Pheniprazine.Approved
ProcaterolThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Procaterol.Approved, Investigational
PropranololPheniprazine may increase the hypotensive activities of Propranolol.Approved, Investigational
ProtriptylinePheniprazine may increase the serotonergic activities of Protriptyline.Approved
PRX-00023The metabolism of PRX-00023 can be decreased when combined with Pheniprazine.Investigational
PseudoephedrinePheniprazine may increase the hypertensive activities of Pseudoephedrine.Approved
QuinaprilPheniprazine may increase the hypotensive activities of Quinapril.Approved, Investigational
QuininePheniprazine may increase the hypoglycemic activities of Quinine.Approved
RamiprilPheniprazine may increase the hypotensive activities of Ramipril.Approved
RasagilineRasagiline may increase the hypertensive activities of Pheniprazine.Approved
RemifentanilRemifentanil may increase the serotonergic activities of Pheniprazine.Approved
RemikirenPheniprazine may increase the hypotensive activities of Remikiren.Approved
RepaglinidePheniprazine may increase the hypoglycemic activities of Repaglinide.Approved, Investigational
RescinnaminePheniprazine may increase the hypotensive activities of Rescinnamine.Approved
ReserpineThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Reserpine.Approved, Investigational
RilmenidinePheniprazine may increase the hypotensive activities of Rilmenidine.Investigational
RiociguatPheniprazine may increase the hypotensive activities of Riociguat.Approved
RitobegronPheniprazine may increase the hypertensive activities of Ritobegron.Investigational
RitodrineThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Ritodrine.Approved, Investigational
RizatriptanThe metabolism of Rizatriptan can be decreased when combined with Pheniprazine.Approved
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Pheniprazine.Approved, Investigational
RosiglitazonePheniprazine may increase the hypoglycemic activities of Rosiglitazone.Approved, Investigational
SafrazinePheniprazine may increase the hypertensive activities of Safrazine.Withdrawn
SalbutamolThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Salbutamol.Approved, Vet Approved
SalmeterolThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Salmeterol.Approved
SaprisartanPheniprazine may increase the hypotensive activities of Saprisartan.Experimental
SaxagliptinPheniprazine may increase the hypoglycemic activities of Saxagliptin.Approved
SelegilineSelegiline may increase the hypertensive activities of Pheniprazine.Approved, Investigational, Vet Approved
SelexipagPheniprazine may increase the hypotensive activities of Selexipag.Approved
SertralinePheniprazine may increase the serotonergic activities of Sertraline.Approved
SitagliptinPheniprazine may increase the hypoglycemic activities of Sitagliptin.Approved, Investigational
SitaxentanPheniprazine may increase the hypotensive activities of Sitaxentan.Approved, Investigational, Withdrawn
SpiraprilPheniprazine may increase the hypotensive activities of Spirapril.Approved
SufentanilSufentanil may increase the serotonergic activities of Pheniprazine.Approved, Investigational
SulfadiazinePheniprazine may increase the hypoglycemic activities of Sulfadiazine.Approved, Vet Approved
SulfamethoxazolePheniprazine may increase the hypoglycemic activities of Sulfamethoxazole.Approved
SulfisoxazolePheniprazine may increase the hypoglycemic activities of Sulfisoxazole.Approved, Vet Approved
SumatriptanThe metabolism of Sumatriptan can be decreased when combined with Pheniprazine.Approved, Investigational
SunitinibPheniprazine may increase the hypoglycemic activities of Sunitinib.Approved, Investigational
TalinololPheniprazine may increase the hypotensive activities of Talinolol.Investigational
TapentadolThe risk or severity of adverse effects can be increased when Tapentadol is combined with Pheniprazine.Approved
TapentadolThe risk or severity of adverse effects can be increased when Tapentadol is combined with Pheniprazine.Approved
TelmisartanPheniprazine may increase the hypotensive activities of Telmisartan.Approved, Investigational
TemocaprilPheniprazine may increase the hypotensive activities of Temocapril.Experimental, Investigational
TerbutalineThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Terbutaline.Approved
TerlipressinPheniprazine may increase the hypotensive activities of Terlipressin.Approved, Investigational
Testosterone PropionateThe risk or severity of adverse effects can be increased when Testosterone Propionate is combined with Pheniprazine.Approved, Vet Approved
TetrabenazineThe risk or severity of adverse effects can be increased when Tetrabenazine is combined with Pheniprazine.Approved
TetrahydropalmatinePheniprazine may increase the hypotensive activities of Tetrahydropalmatine.Investigational
TetryzolinePheniprazine may increase the hypertensive activities of Tetryzoline.Approved
TheodrenalinePheniprazine may increase the hypotensive activities of Theodrenaline.Investigational
TianeptineThe risk or severity of adverse effects can be increased when Tianeptine is combined with Pheniprazine.Approved, Investigational
TibolonePheniprazine may increase the hypotensive activities of Tibolone.Approved, Investigational
TicrynafenPheniprazine may increase the hypotensive activities of Ticrynafen.Withdrawn
TilidineThe risk or severity of adverse effects can be increased when Tilidine is combined with Pheniprazine.Experimental
TimololPheniprazine may increase the hypotensive activities of Timolol.Approved
TolazamidePheniprazine may increase the hypoglycemic activities of Tolazamide.Approved
TolazolinePheniprazine may increase the hypotensive activities of Tolazoline.Approved, Vet Approved
TolbutamidePheniprazine may increase the hypoglycemic activities of Tolbutamide.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Pheniprazine.Approved, Withdrawn
TolonidinePheniprazine may increase the hypotensive activities of Tolonidine.Experimental
ToloxatoneToloxatone may increase the hypertensive activities of Pheniprazine.Approved
TorasemidePheniprazine may increase the hypotensive activities of Torasemide.Approved
TramadolTramadol may increase the neuroexcitatory activities of Pheniprazine.Approved, Investigational
TrandolaprilPheniprazine may increase the hypotensive activities of Trandolapril.Approved
Trans-2-PhenylcyclopropylamineTrans-2-Phenylcyclopropylamine may increase the hypertensive activities of Pheniprazine.Experimental
TranylcypromineTranylcypromine may increase the hypertensive activities of Pheniprazine.Approved
TravoprostPheniprazine may increase the hypotensive activities of Travoprost.Approved
TrazodoneThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Trazodone.Approved, Investigational
TreprostinilPheniprazine may increase the hypotensive activities of Treprostinil.Approved, Investigational
TrichlormethiazidePheniprazine may increase the hypotensive activities of Trichlormethiazide.Approved, Vet Approved
TrimazosinPheniprazine may increase the hypotensive activities of Trimazosin.Experimental
TrimethaphanPheniprazine may increase the hypotensive activities of Trimethaphan.Approved, Investigational
TrimipraminePheniprazine may increase the serotonergic activities of Trimipramine.Approved
UnoprostonePheniprazine may increase the hypotensive activities of Unoprostone.Approved
UrapidilPheniprazine may increase the hypotensive activities of Urapidil.Investigational
ValsartanPheniprazine may increase the hypotensive activities of Valsartan.Approved, Investigational
VenlafaxinePheniprazine may increase the serotonergic activities of Venlafaxine.Approved
VilanterolThe risk or severity of adverse effects can be increased when Pheniprazine is combined with Vilanterol.Approved
VilazodoneThe metabolism of Vilazodone can be decreased when combined with Pheniprazine.Approved
VincaminePheniprazine may increase the hypotensive activities of Vincamine.Experimental
VinpocetinePheniprazine may increase the hypotensive activities of Vinpocetine.Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Pheniprazine.Approved
XipamidePheniprazine may increase the hypotensive activities of Xipamide.Experimental
XylometazolinePheniprazine may increase the hypotensive activities of Xylometazoline.Approved
ZimelidinePheniprazine may increase the serotonergic activities of Zimelidine.Withdrawn
ZofenoprilPheniprazine may increase the hypotensive activities of Zofenopril.Experimental
ZolmitriptanThe metabolism of Zolmitriptan can be decreased when combined with Pheniprazine.Approved, Investigational
Food Interactions
Not Available

References

General References
  1. LEAR TE, BROWNE MW, GREEVES JA: A controlled trial of cavodil (pheniprazine) in depression. J Ment Sci. 1962 Nov;108:856-58. [PubMed:13928843]
  2. SANDLER G: Clinical evaluation of pheniprazine in angina pectoris. Br Med J. 1961 Mar 18;1(5228):792-4. [PubMed:13746179]
  3. WICKSTROM L, HAHN N: [beta-Phenylisoprophlhydrazine (Catran) in schizophrenia]. Nord Med. 1962 Sep 13;68:1165-7. [PubMed:14000469]
External Links
PubChem Compound
5929
PubChem Substance
310265153
ChemSpider
5716
ChEBI
134773
ChEMBL
CHEMBL22498
Wikipedia
Pheniprazine

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility3.75 mg/mLALOGPS
logP1.69ALOGPS
logP1.62ChemAxon
logS-1.6ALOGPS
pKa (Strongest Basic)5.65ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area38.05 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity58.68 m3·mol-1ChemAxon
Polarizability17.47 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as amphetamines and derivatives. These are organic compounds containing or derived from 1-phenylpropan-2-amine.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Phenethylamines
Direct Parent
Amphetamines and derivatives
Alternative Parents
Phenylpropanes / Alkylhydrazines / Organopnictogen compounds / Hydrocarbon derivatives
Substituents
Amphetamine or derivatives / Phenylpropane / Alkylhydrazine / Organic nitrogen compound / Organopnictogen compound / Hydrocarbon derivative / Organonitrogen compound / Hydrazine derivative / Aromatic homomonocyclic compound
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
Not Available

Drug created on October 23, 2015 22:06 / Updated on December 01, 2017 17:22