Pivhydrazine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Pivhydrazine
Accession Number
DB09252
Type
Small Molecule
Groups
Withdrawn
Description

Pivhydrazine (BAN), also known as pivalylbenzhydrazine and pivazide, is an irreversible and non-selective monoamine oxidase inhibitor (MAOI) of the hydrazine family. It was formerly used as an antidepressant in the 1960s, but has since been discontinued.

Structure
Thumb
Synonyms
  • Pivalylbenzhydrazine
  • Pivazide
International/Other Brands
Angorvid / Betamezid / Neomarsilid / Tersavid
Categories
UNII
TK1T520ASG
CAS number
306-19-4
Weight
Average: 206.289
Monoisotopic: 206.141913208
Chemical Formula
C12H18N2O
InChI Key
FWWDFDMCZLOXQI-UHFFFAOYSA-N
InChI
InChI=1S/C12H18N2O/c1-12(2,3)11(15)14-13-9-10-7-5-4-6-8-10/h4-8,13H,9H2,1-3H3,(H,14,15)
IUPAC Name
N'-benzyl-2,2-dimethylpropanehydrazide
SMILES
[H]N(CC1=CC=CC=C1)N([H])C(=O)C(C)(C)C

Pharmacology

Indication

For the treatment of depression.

Structured Indications
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
2,5-Dimethoxy-4-ethylamphetaminePivhydrazine may increase the hypertensive activities of 2,5-Dimethoxy-4-ethylamphetamine.Experimental, Illicit
3,4-MethylenedioxyamphetaminePivhydrazine may increase the hypertensive activities of 3,4-Methylenedioxyamphetamine.Experimental, Illicit
4-Bromo-2,5-dimethoxyamphetaminePivhydrazine may increase the hypertensive activities of 4-Bromo-2,5-dimethoxyamphetamine.Experimental, Illicit
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline may increase the hypertensive activities of Pivhydrazine.Experimental
AcarbosePivhydrazine may increase the hypoglycemic activities of Acarbose.Approved, Investigational
AcebutololPivhydrazine may increase the hypotensive activities of Acebutolol.Approved
AlaproclateThe risk or severity of adverse effects can be increased when Alaproclate is combined with Pivhydrazine.Experimental
AlbiglutidePivhydrazine may increase the hypoglycemic activities of Albiglutide.Approved
AlfentanilAlfentanil may increase the serotonergic activities of Pivhydrazine.Approved, Illicit
AliskirenPivhydrazine may increase the hypotensive activities of Aliskiren.Approved, Investigational
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Pivhydrazine.Approved, Investigational
AlogliptinPivhydrazine may increase the hypoglycemic activities of Alogliptin.Approved
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Pivhydrazine.Experimental, Illicit
AlphaprodineThe risk or severity of adverse effects can be increased when Alphaprodine is combined with Pivhydrazine.Illicit
AlprenololPivhydrazine may increase the hypotensive activities of Alprenolol.Approved, Withdrawn
AltretamineAltretamine may increase the orthostatic hypotensive activities of Pivhydrazine.Approved
AmbrisentanPivhydrazine may increase the hypotensive activities of Ambrisentan.Approved, Investigational
AmineptinePivhydrazine may increase the serotonergic activities of Amineptine.Illicit, Withdrawn
AmitriptylinePivhydrazine may increase the serotonergic activities of Amitriptyline.Approved
AmlodipinePivhydrazine may increase the hypotensive activities of Amlodipine.Approved
AmoxapineThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Amoxapine.Approved
AmphetaminePivhydrazine may increase the hypertensive activities of Amphetamine.Approved, Illicit
ApomorphineThe metabolism of Apomorphine can be decreased when combined with Pivhydrazine.Approved, Investigational
ApraclonidineThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Apraclonidine.Approved
ArbutamineThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Arbutamine.Approved
ArformoterolThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Arformoterol.Approved, Investigational
AtenololPivhydrazine may increase the hypotensive activities of Atenolol.Approved
AtomoxetinePivhydrazine may increase the central neurotoxic activities of Atomoxetine.Approved
AtropinePivhydrazine may increase the hypertensive activities of Atropine.Approved, Vet Approved
BambuterolThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Bambuterol.Approved, Investigational
BenazeprilPivhydrazine may increase the hypotensive activities of Benazepril.Approved, Investigational
BendroflumethiazidePivhydrazine may increase the hypotensive activities of Bendroflumethiazide.Approved
BenmoxinBenmoxin may increase the hypertensive activities of Pivhydrazine.Withdrawn
BenzphetaminePivhydrazine may increase the hypertensive activities of Benzphetamine.Approved, Illicit
BepridilPivhydrazine may increase the hypotensive activities of Bepridil.Approved, Withdrawn
BetahistineThe serum concentration of Betahistine can be increased when it is combined with Pivhydrazine.Approved
BetaxololPivhydrazine may increase the hypotensive activities of Betaxolol.Approved
BethanidinePivhydrazine may increase the hypotensive activities of Bethanidine.Approved
BezafibrateThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Bezafibrate.Approved
BietaserpinePivhydrazine may increase the hypotensive activities of Bietaserpine.Experimental
BimatoprostPivhydrazine may increase the hypotensive activities of Bimatoprost.Approved, Investigational
BisoprololPivhydrazine may increase the hypotensive activities of Bisoprolol.Approved
BosentanPivhydrazine may increase the hypotensive activities of Bosentan.Approved, Investigational
BQ-123Pivhydrazine may increase the hypotensive activities of BQ-123.Investigational
BretyliumPivhydrazine may increase the hypotensive activities of Bretylium.Approved
BrimonidineThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Brimonidine.Approved
BrofaromineBrofaromine may increase the hypertensive activities of Pivhydrazine.Experimental
BromocriptinePivhydrazine may increase the hypoglycemic activities of Bromocriptine.Approved, Investigational
BupranololPivhydrazine may increase the hypotensive activities of Bupranolol.Approved
BuprenorphineThe risk or severity of adverse effects can be increased when Buprenorphine is combined with Pivhydrazine.Approved, Illicit, Investigational, Vet Approved
BupropionPivhydrazine may increase the hypertensive activities of Bupropion.Approved
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Pivhydrazine.Approved, Investigational
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Pivhydrazine.Approved, Illicit, Vet Approved
CabergolineThe metabolism of Cabergoline can be decreased when combined with Pivhydrazine.Approved
CadralazinePivhydrazine may increase the hypotensive activities of Cadralazine.Experimental
CafedrinePivhydrazine may increase the hypotensive activities of Cafedrine.Investigational
CanagliflozinPivhydrazine may increase the hypoglycemic activities of Canagliflozin.Approved
CandesartanPivhydrazine may increase the hypotensive activities of Candesartan.Experimental
Candesartan cilexetilPivhydrazine may increase the hypotensive activities of Candesartan cilexetil.Approved
CandoxatrilPivhydrazine may increase the hypotensive activities of Candoxatril.Experimental
CaptoprilPivhydrazine may increase the hypotensive activities of Captopril.Approved
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Pivhydrazine.Approved, Investigational
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Pivhydrazine.Illicit, Investigational, Vet Approved
CaroxazonePivhydrazine may increase the hypertensive activities of Caroxazone.Withdrawn
CarteololPivhydrazine may increase the hypotensive activities of Carteolol.Approved
CarvedilolPivhydrazine may increase the hypotensive activities of Carvedilol.Approved, Investigational
CeliprololPivhydrazine may increase the hypotensive activities of Celiprolol.Approved, Investigational
ChlorothiazidePivhydrazine may increase the hypotensive activities of Chlorothiazide.Approved, Vet Approved
ChlorphenterminePivhydrazine may increase the hypertensive activities of Chlorphentermine.Illicit, Withdrawn
ChlorpropamidePivhydrazine may increase the hypoglycemic activities of Chlorpropamide.Approved
ChlorthalidonePivhydrazine may increase the hypotensive activities of Chlorthalidone.Approved
CicletaninePivhydrazine may increase the hypotensive activities of Cicletanine.Investigational
CilazaprilPivhydrazine may increase the hypotensive activities of Cilazapril.Approved
CirazolinePivhydrazine may increase the hypertensive activities of Cirazoline.Experimental
CitalopramPivhydrazine may increase the serotonergic activities of Citalopram.Approved
ClemastinePivhydrazine may increase the anticholinergic activities of Clemastine.Approved
ClenbuterolThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Clenbuterol.Approved, Investigational, Vet Approved
ClomipraminePivhydrazine may increase the serotonergic activities of Clomipramine.Approved, Vet Approved
ClonidinePivhydrazine may increase the hypotensive activities of Clonidine.Approved
CloranololPivhydrazine may increase the hypotensive activities of Cloranolol.Experimental
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Pivhydrazine.Approved, Illicit
CryptenaminePivhydrazine may increase the hypotensive activities of Cryptenamine.Approved
CyclobenzaprineCyclobenzaprine may increase the serotonergic activities of Pivhydrazine.Approved
CyclopenthiazidePivhydrazine may increase the hypotensive activities of Cyclopenthiazide.Experimental
CyclothiazidePivhydrazine may increase the hypotensive activities of Cyclothiazide.Approved
CyproheptadinePivhydrazine may increase the anticholinergic activities of Cyproheptadine.Approved
DapagliflozinPivhydrazine may increase the hypoglycemic activities of Dapagliflozin.Approved
DapoxetinePivhydrazine may increase the serotonergic activities of Dapoxetine.Investigational
DebrisoquinPivhydrazine may increase the hypotensive activities of Debrisoquin.Approved, Investigational
DelaprilPivhydrazine may increase the hypotensive activities of Delapril.Experimental
DeserpidinePivhydrazine may increase the hypotensive activities of Deserpidine.Approved
DesipraminePivhydrazine may increase the serotonergic activities of Desipramine.Approved
DesvenlafaxinePivhydrazine may increase the serotonergic activities of Desvenlafaxine.Approved
DexmethylphenidatePivhydrazine may increase the hypertensive activities of Dexmethylphenidate.Approved
DextroamphetaminePivhydrazine may increase the hypertensive activities of Dextroamphetamine.Approved, Illicit
DextromethorphanPivhydrazine may increase the serotonergic activities of Dextromethorphan.Approved
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Pivhydrazine.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Pivhydrazine.Approved, Illicit, Investigational, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Pivhydrazine.Approved, Investigational
DiazoxidePivhydrazine may increase the hypotensive activities of Diazoxide.Approved
DibenzepinPivhydrazine may increase the serotonergic activities of Dibenzepin.Experimental
diethylnorsperminePivhydrazine may increase the hypotensive activities of diethylnorspermine.Investigational
DiethylpropionPivhydrazine may increase the hypertensive activities of Diethylpropion.Approved, Illicit
DihydralazinePivhydrazine may increase the hypotensive activities of Dihydralazine.Investigational
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Pivhydrazine.Approved, Illicit
DihydroergotamineThe metabolism of Dihydroergotamine can be decreased when combined with Pivhydrazine.Approved
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Pivhydrazine.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Pivhydrazine.Experimental, Illicit
DiltiazemPivhydrazine may increase the hypotensive activities of Diltiazem.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Pivhydrazine.Approved, Illicit
DipivefrinThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Dipivefrin.Approved
DisopyramidePivhydrazine may increase the hypoglycemic activities of Disopyramide.Approved
DobutamineThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Dobutamine.Approved
DomperidoneThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Domperidone.Approved, Investigational, Vet Approved
DorzolamidePivhydrazine may increase the hypotensive activities of Dorzolamide.Approved
DosulepinPivhydrazine may increase the serotonergic activities of Dosulepin.Approved
DoxapramPivhydrazine may increase the hypertensive activities of Doxapram.Approved, Vet Approved
DoxazosinPivhydrazine may increase the hypotensive activities of Doxazosin.Approved
DoxepinPivhydrazine may increase the serotonergic activities of Doxepin.Approved
DoxylaminePivhydrazine may increase the anticholinergic activities of Doxylamine.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when DPDPE is combined with Pivhydrazine.Experimental
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Pivhydrazine.Experimental, Illicit
DroxidopaThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Droxidopa.Approved, Investigational
DulaglutidePivhydrazine may increase the hypoglycemic activities of Dulaglutide.Approved
DuloxetinePivhydrazine may increase the serotonergic activities of Duloxetine.Approved
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Pivhydrazine.Experimental, Illicit
EfonidipinePivhydrazine may increase the hypotensive activities of Efonidipine.Approved, Investigational
EletriptanThe metabolism of Eletriptan can be decreased when combined with Pivhydrazine.Approved, Investigational
EmpagliflozinPivhydrazine may increase the hypoglycemic activities of Empagliflozin.Approved
EnalaprilPivhydrazine may increase the hypotensive activities of Enalapril.Approved, Vet Approved
EnalaprilatPivhydrazine may increase the hypotensive activities of Enalaprilat.Approved
EndralazinePivhydrazine may increase the hypotensive activities of Endralazine.Experimental
EntacaponeThe risk or severity of adverse effects can be increased when Entacapone is combined with Pivhydrazine.Approved, Investigational
EpanololPivhydrazine may increase the hypotensive activities of Epanolol.Experimental
EphedraThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Ephedra.Approved, Nutraceutical, Withdrawn
EpinephrinePivhydrazine may increase the hypertensive activities of Epinephrine.Approved, Vet Approved
EpoprostenolPivhydrazine may increase the hypotensive activities of Epoprostenol.Approved
EprosartanPivhydrazine may increase the hypotensive activities of Eprosartan.Approved
ErgotaminePivhydrazine may increase the hypertensive activities of Ergotamine.Approved
EscitalopramPivhydrazine may increase the serotonergic activities of Escitalopram.Approved, Investigational
EsmirtazapinePivhydrazine may increase the serotonergic activities of Esmirtazapine.Investigational
EthanolThe risk or severity of adverse effects can be increased when Ethanol is combined with Pivhydrazine.Approved
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Pivhydrazine.Approved, Illicit
EtoperidonePivhydrazine may increase the serotonergic activities of Etoperidone.Withdrawn
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Pivhydrazine.Illicit, Vet Approved
ExenatidePivhydrazine may increase the hypoglycemic activities of Exenatide.Approved, Investigational
FelodipinePivhydrazine may increase the hypotensive activities of Felodipine.Approved, Investigational
FenfluramineThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Fenfluramine.Illicit, Investigational, Withdrawn
FenoldopamPivhydrazine may increase the hypotensive activities of Fenoldopam.Approved
FenoterolThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Fenoterol.Approved, Investigational
FentanylFentanyl may increase the serotonergic activities of Pivhydrazine.Approved, Illicit, Investigational, Vet Approved
Ferulic acidPivhydrazine may increase the hypotensive activities of Ferulic acid.Experimental
FluoxetinePivhydrazine may increase the serotonergic activities of Fluoxetine.Approved, Vet Approved
FluvoxaminePivhydrazine may increase the serotonergic activities of Fluvoxamine.Approved, Investigational
FormoterolThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Formoterol.Approved, Investigational
FosinoprilPivhydrazine may increase the hypotensive activities of Fosinopril.Approved
FrovatriptanThe metabolism of Frovatriptan can be decreased when combined with Pivhydrazine.Approved, Investigational
FurazolidoneFurazolidone may increase the hypertensive activities of Pivhydrazine.Approved, Investigational, Vet Approved
GepefrineThe risk or severity of adverse effects can be increased when Gepefrine is combined with Pivhydrazine.Experimental
GliclazidePivhydrazine may increase the hypoglycemic activities of Gliclazide.Approved
GlimepiridePivhydrazine may increase the hypoglycemic activities of Glimepiride.Approved
GlipizidePivhydrazine may increase the hypoglycemic activities of Glipizide.Approved
GlyburidePivhydrazine may increase the hypoglycemic activities of Glyburide.Approved
GuanabenzPivhydrazine may increase the hypotensive activities of Guanabenz.Approved, Investigational
GuanadrelPivhydrazine may increase the hypotensive activities of Guanadrel.Approved
GuanazodinePivhydrazine may increase the hypotensive activities of Guanazodine.Experimental
GuanethidinePivhydrazine may increase the hypotensive activities of Guanethidine.Approved
GuanfacinePivhydrazine may increase the hypotensive activities of Guanfacine.Approved, Investigational
GuanoclorPivhydrazine may increase the hypotensive activities of Guanoclor.Experimental
GuanoxabenzPivhydrazine may increase the hypotensive activities of Guanoxabenz.Experimental
GuanoxanPivhydrazine may increase the hypotensive activities of Guanoxan.Experimental
HarmalineHarmaline may increase the hypertensive activities of Pivhydrazine.Experimental
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Pivhydrazine.Approved, Illicit, Investigational
HexamethoniumPivhydrazine may increase the hypotensive activities of Hexamethonium.Experimental
HydracarbazineHydracarbazine may increase the hypertensive activities of Pivhydrazine.Experimental
HydralazinePivhydrazine may increase the hypotensive activities of Hydralazine.Approved
HydrochlorothiazidePivhydrazine may increase the hypotensive activities of Hydrochlorothiazide.Approved, Vet Approved
HydrocodoneThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Hydrocodone.Approved, Illicit
HydroflumethiazidePivhydrazine may increase the hypotensive activities of Hydroflumethiazide.Approved, Investigational
HydromorphoneThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Hydromorphone.Approved, Illicit
HydroxyamphetaminePivhydrazine may increase the hypertensive activities of Hydroxyamphetamine.Approved
ImidaprilPivhydrazine may increase the hypotensive activities of Imidapril.Investigational
ImipraminePivhydrazine may increase the serotonergic activities of Imipramine.Approved
IndacaterolThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Indacaterol.Approved
IndalpinePivhydrazine may increase the serotonergic activities of Indalpine.Investigational, Withdrawn
IndapamidePivhydrazine may increase the hypotensive activities of Indapamide.Approved
IndenololPivhydrazine may increase the hypotensive activities of Indenolol.Withdrawn
IndoraminPivhydrazine may increase the hypotensive activities of Indoramin.Withdrawn
Insulin AspartPivhydrazine may increase the hypoglycemic activities of Insulin Aspart.Approved
Insulin DetemirPivhydrazine may increase the hypoglycemic activities of Insulin Detemir.Approved
Insulin GlarginePivhydrazine may increase the hypoglycemic activities of Insulin Glargine.Approved
Insulin GlulisinePivhydrazine may increase the hypoglycemic activities of Insulin Glulisine.Approved
Insulin HumanPivhydrazine may increase the hypoglycemic activities of Insulin Human.Approved, Investigational
Insulin LisproPivhydrazine may increase the hypoglycemic activities of Insulin Lispro.Approved
Iofetamine I-123The risk or severity of adverse effects can be increased when Iofetamine I-123 is combined with Pivhydrazine.Approved
IprindolePivhydrazine may increase the serotonergic activities of Iprindole.Experimental
IproclozideIproclozide may increase the hypertensive activities of Pivhydrazine.Withdrawn
IproniazidIproniazid may increase the hypertensive activities of Pivhydrazine.Withdrawn
IrbesartanPivhydrazine may increase the hypotensive activities of Irbesartan.Approved, Investigational
IsocarboxazidIsocarboxazid may increase the hypertensive activities of Pivhydrazine.Approved
IsoetarineThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Isoetarine.Approved
IsomethepteneThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Isometheptene.Approved
IsoprenalineThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Isoprenaline.Approved
IsradipinePivhydrazine may increase the hypotensive activities of Isradipine.Approved
KetanserinPivhydrazine may increase the hypotensive activities of Ketanserin.Investigational
KetobemidoneThe risk or severity of adverse effects can be increased when Ketobemidone is combined with Pivhydrazine.Approved, Investigational
L-TryptophanThe risk or severity of adverse effects can be increased when L-Tryptophan is combined with Pivhydrazine.Approved, Nutraceutical, Withdrawn
LabetalolPivhydrazine may increase the hypotensive activities of Labetalol.Approved
LacidipinePivhydrazine may increase the hypotensive activities of Lacidipine.Approved, Investigational
LatanoprostPivhydrazine may increase the hypotensive activities of Latanoprost.Approved, Investigational
LercanidipinePivhydrazine may increase the hypotensive activities of Lercanidipine.Approved, Investigational
LevodopaThe risk or severity of adverse effects can be increased when Levodopa is combined with Pivhydrazine.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Pivhydrazine.Approved, Investigational
LevomilnacipranPivhydrazine may increase the serotonergic activities of Levomilnacipran.Approved
LevonordefrinPivhydrazine may increase the hypertensive activities of Levonordefrin.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Pivhydrazine.Approved
LevosalbutamolThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Levosalbutamol.Approved
LinezolidThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Linezolid.Approved, Investigational
LinsidominePivhydrazine may increase the hypotensive activities of Linsidomine.Experimental
LiraglutidePivhydrazine may increase the hypoglycemic activities of Liraglutide.Approved
LisdexamfetaminePivhydrazine may increase the hypertensive activities of Lisdexamfetamine.Approved, Investigational
LisinoprilPivhydrazine may increase the hypotensive activities of Lisinopril.Approved, Investigational
LisurideThe metabolism of Lisuride can be decreased when combined with Pivhydrazine.Approved, Investigational
LithiumThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Lithium.Approved
LofentanilThe risk or severity of adverse effects can be increased when Lofentanil is combined with Pivhydrazine.Illicit
LofepraminePivhydrazine may increase the serotonergic activities of Lofepramine.Experimental
LofexidinePivhydrazine may increase the hypotensive activities of Lofexidine.Approved, Investigational
LosartanPivhydrazine may increase the hypotensive activities of Losartan.Approved
MacitentanPivhydrazine may increase the hypotensive activities of Macitentan.Approved
ManidipinePivhydrazine may increase the hypotensive activities of Manidipine.Approved, Investigational
MaprotilineThe risk or severity of adverse effects can be increased when Maprotiline is combined with Pivhydrazine.Approved
MebanazineMebanazine may increase the hypertensive activities of Pivhydrazine.Withdrawn
MecamylaminePivhydrazine may increase the hypotensive activities of Mecamylamine.Approved
MecaserminPivhydrazine may increase the hypoglycemic activities of Mecasermin.Approved, Investigational
MephedronePivhydrazine may increase the hypertensive activities of Mephedrone.Investigational
MephenterminePivhydrazine may increase the hypertensive activities of Mephentermine.Approved
MeptazinolThe risk or severity of adverse effects can be increased when Meptazinol is combined with Pivhydrazine.Experimental
MequitazinePivhydrazine may increase the anticholinergic activities of Mequitazine.Approved
MetaraminolPivhydrazine may increase the hypertensive activities of Metaraminol.Approved, Investigational
MetforminPivhydrazine may increase the hypoglycemic activities of Metformin.Approved
MethadoneThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Methadone.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Pivhydrazine.Approved, Illicit
MethamphetaminePivhydrazine may increase the hypertensive activities of Methamphetamine.Approved, Illicit
MethoserpidinePivhydrazine may increase the hypotensive activities of Methoserpidine.Experimental
MethoxaminePivhydrazine may increase the hypertensive activities of Methoxamine.Approved, Investigational
MethoxyphenamineThe risk or severity of adverse effects can be increased when Methoxyphenamine is combined with Pivhydrazine.Experimental
MethyldopaThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Methyldopa.Approved
MethylecgonineThe risk or severity of adverse effects can be increased when Methylecgonine is combined with Pivhydrazine.Experimental
Methylene bluePivhydrazine may increase the serotonergic activities of Methylene blue.Approved, Investigational
MethylphenidatePivhydrazine may increase the hypertensive activities of Methylphenidate.Approved, Investigational
MetipranololPivhydrazine may increase the hypotensive activities of Metipranolol.Approved
MetolazonePivhydrazine may increase the hypotensive activities of Metolazone.Approved
MetoprololPivhydrazine may increase the hypotensive activities of Metoprolol.Approved, Investigational
MetyrosinePivhydrazine may increase the hypotensive activities of Metyrosine.Approved
MianserinPivhydrazine may increase the neurotoxic activities of Mianserin.Approved, Investigational
MibefradilPivhydrazine may increase the hypotensive activities of Mibefradil.Investigational, Withdrawn
MidodrinePivhydrazine may increase the hypertensive activities of Midodrine.Approved
MidomafetaminePivhydrazine may increase the hypertensive activities of Midomafetamine.Experimental, Illicit, Investigational
MifepristonePivhydrazine may increase the hypoglycemic activities of Mifepristone.Approved, Investigational
MiglitolPivhydrazine may increase the hypoglycemic activities of Miglitol.Approved
MilnacipranPivhydrazine may increase the serotonergic activities of Milnacipran.Approved
MinaprineMinaprine may increase the hypertensive activities of Pivhydrazine.Approved
MinoxidilPivhydrazine may increase the hypotensive activities of Minoxidil.Approved
MirtazapinePivhydrazine may increase the central neurotoxic activities of Mirtazapine.Approved
MMDAPivhydrazine may increase the hypertensive activities of MMDA.Experimental, Illicit
MoclobemideThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Moclobemide.Approved
MoexiprilPivhydrazine may increase the hypotensive activities of Moexipril.Approved
MorphineThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Morphine.Approved, Investigational
MoxonidinePivhydrazine may increase the hypotensive activities of Moxonidine.Approved, Investigational
MuzoliminePivhydrazine may increase the hypotensive activities of Muzolimine.Experimental
NadololPivhydrazine may increase the hypotensive activities of Nadolol.Approved
NaftopidilPivhydrazine may increase the hypotensive activities of Naftopidil.Investigational
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Pivhydrazine.Approved
NaratriptanThe metabolism of Naratriptan can be decreased when combined with Pivhydrazine.Approved, Investigational
NateglinidePivhydrazine may increase the hypoglycemic activities of Nateglinide.Approved, Investigational
NebivololPivhydrazine may increase the hypotensive activities of Nebivolol.Approved, Investigational
NefazodonePivhydrazine may increase the serotonergic activities of Nefazodone.Approved, Withdrawn
NialamideNialamide may increase the hypertensive activities of Pivhydrazine.Withdrawn
NicardipinePivhydrazine may increase the hypotensive activities of Nicardipine.Approved
NicorandilPivhydrazine may increase the hypotensive activities of Nicorandil.Approved, Investigational
NiguldipinePivhydrazine may increase the hypotensive activities of Niguldipine.Experimental
NilvadipinePivhydrazine may increase the hypotensive activities of Nilvadipine.Approved, Investigational
NimodipinePivhydrazine may increase the hypotensive activities of Nimodipine.Approved
NisoldipinePivhydrazine may increase the hypotensive activities of Nisoldipine.Approved
NitrendipinePivhydrazine may increase the hypotensive activities of Nitrendipine.Approved, Investigational
NitroprussidePivhydrazine may increase the hypotensive activities of Nitroprusside.Approved
NorepinephrinePivhydrazine may increase the hypertensive activities of Norepinephrine.Approved
NormethadoneThe risk or severity of adverse effects can be increased when Normethadone is combined with Pivhydrazine.Approved, Illicit
NortriptylinePivhydrazine may increase the serotonergic activities of Nortriptyline.Approved
OctamoxinOctamoxin may increase the hypertensive activities of Pivhydrazine.Withdrawn
OlanzapineThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Olanzapine.Approved, Investigational
OlmesartanPivhydrazine may increase the hypotensive activities of Olmesartan.Approved, Investigational
OlodaterolThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Olodaterol.Approved
OmapatrilatPivhydrazine may increase the hypotensive activities of Omapatrilat.Investigational
OpipramolPivhydrazine may increase the serotonergic activities of Opipramol.Investigational
OpiumThe risk or severity of adverse effects can be increased when Opium is combined with Pivhydrazine.Approved, Illicit
OrciprenalineThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Orciprenaline.Approved
OxprenololPivhydrazine may increase the hypotensive activities of Oxprenolol.Approved
OxycodoneThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Pivhydrazine.Approved, Investigational, Vet Approved
PargylinePivhydrazine may increase the hypotensive activities of Pargyline.Approved
ParoxetinePivhydrazine may increase the serotonergic activities of Paroxetine.Approved, Investigational
PenbutololPivhydrazine may increase the hypotensive activities of Penbutolol.Approved, Investigational
PentamidinePivhydrazine may increase the hypoglycemic activities of Pentamidine.Approved
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Pivhydrazine.Approved, Vet Approved
PentoliniumPivhydrazine may increase the hypotensive activities of Pentolinium.Approved
PergolideThe metabolism of Pergolide can be decreased when combined with Pivhydrazine.Approved, Investigational, Vet Approved, Withdrawn
PerindoprilPivhydrazine may increase the hypotensive activities of Perindopril.Approved
PethidinePivhydrazine may increase the serotonergic activities of Pethidine.Approved
PhenazocineThe risk or severity of adverse effects can be increased when Phenazocine is combined with Pivhydrazine.Experimental
PhenelzinePhenelzine may increase the hypertensive activities of Pivhydrazine.Approved
PheniprazinePheniprazine may increase the hypertensive activities of Pivhydrazine.Withdrawn
PhenoperidineThe risk or severity of adverse effects can be increased when Phenoperidine is combined with Pivhydrazine.Experimental
PhenoxybenzaminePivhydrazine may increase the hypotensive activities of Phenoxybenzamine.Approved
PhenoxypropazinePhenoxypropazine may increase the hypertensive activities of Pivhydrazine.Withdrawn
PhenterminePivhydrazine may increase the hypertensive activities of Phentermine.Approved, Illicit
PhentolaminePivhydrazine may increase the hypotensive activities of Phentolamine.Approved
PhenylephrinePivhydrazine may increase the hypertensive activities of Phenylephrine.Approved
PhenylpropanolamineThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Phenylpropanolamine.Approved, Vet Approved, Withdrawn
PholcodinePholcodine may increase the serotonergic activities of Pivhydrazine.Approved, Illicit
PiclozotanThe metabolism of Piclozotan can be decreased when combined with Pivhydrazine.Investigational
PinacidilPivhydrazine may increase the hypotensive activities of Pinacidil.Withdrawn
PindololPivhydrazine may increase the hypotensive activities of Pindolol.Approved
PioglitazonePivhydrazine may increase the hypoglycemic activities of Pioglitazone.Approved, Investigational
PirbuterolThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Pirbuterol.Approved
PiritramideThe risk or severity of adverse effects can be increased when Piritramide is combined with Pivhydrazine.Investigational
PirlindolePirlindole may increase the hypertensive activities of Pivhydrazine.Approved
PizotifenPivhydrazine may increase the anticholinergic activities of Pizotifen.Approved
Platelet Activating FactorPivhydrazine may increase the hypotensive activities of Platelet Activating Factor.Experimental
PolythiazidePivhydrazine may increase the hypotensive activities of Polythiazide.Approved
PramlintidePivhydrazine may increase the hypoglycemic activities of Pramlintide.Approved, Investigational
PrazosinPivhydrazine may increase the hypotensive activities of Prazosin.Approved
ProcarbazineProcarbazine may increase the hypertensive activities of Pivhydrazine.Approved
ProcaterolThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Procaterol.Approved, Investigational
PropranololPivhydrazine may increase the hypotensive activities of Propranolol.Approved, Investigational
ProtriptylinePivhydrazine may increase the serotonergic activities of Protriptyline.Approved
PRX-00023The metabolism of PRX-00023 can be decreased when combined with Pivhydrazine.Investigational
PseudoephedrinePivhydrazine may increase the hypertensive activities of Pseudoephedrine.Approved
QuinaprilPivhydrazine may increase the hypotensive activities of Quinapril.Approved, Investigational
QuininePivhydrazine may increase the hypoglycemic activities of Quinine.Approved
RamiprilPivhydrazine may increase the hypotensive activities of Ramipril.Approved
RasagilineRasagiline may increase the hypertensive activities of Pivhydrazine.Approved
RemifentanilRemifentanil may increase the serotonergic activities of Pivhydrazine.Approved
RemikirenPivhydrazine may increase the hypotensive activities of Remikiren.Approved
RepaglinidePivhydrazine may increase the hypoglycemic activities of Repaglinide.Approved, Investigational
RescinnaminePivhydrazine may increase the hypotensive activities of Rescinnamine.Approved
ReserpineThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Reserpine.Approved, Investigational
RilmenidinePivhydrazine may increase the hypotensive activities of Rilmenidine.Investigational
RiociguatPivhydrazine may increase the hypotensive activities of Riociguat.Approved
RitobegronPivhydrazine may increase the hypertensive activities of Ritobegron.Investigational
RitodrineThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Ritodrine.Approved, Investigational
RizatriptanThe metabolism of Rizatriptan can be decreased when combined with Pivhydrazine.Approved
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Pivhydrazine.Approved, Investigational
RosiglitazonePivhydrazine may increase the hypoglycemic activities of Rosiglitazone.Approved, Investigational
SafrazinePivhydrazine may increase the hypertensive activities of Safrazine.Withdrawn
SalbutamolThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Salbutamol.Approved, Vet Approved
SalmeterolThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Salmeterol.Approved
SaprisartanPivhydrazine may increase the hypotensive activities of Saprisartan.Experimental
SaxagliptinPivhydrazine may increase the hypoglycemic activities of Saxagliptin.Approved
SelegilineSelegiline may increase the hypertensive activities of Pivhydrazine.Approved, Investigational, Vet Approved
SelexipagPivhydrazine may increase the hypotensive activities of Selexipag.Approved
SertralinePivhydrazine may increase the serotonergic activities of Sertraline.Approved
SitagliptinPivhydrazine may increase the hypoglycemic activities of Sitagliptin.Approved, Investigational
SitaxentanPivhydrazine may increase the hypotensive activities of Sitaxentan.Approved, Investigational, Withdrawn
SpiraprilPivhydrazine may increase the hypotensive activities of Spirapril.Approved
SufentanilSufentanil may increase the serotonergic activities of Pivhydrazine.Approved, Investigational
SulfadiazinePivhydrazine may increase the hypoglycemic activities of Sulfadiazine.Approved, Vet Approved
SulfamethoxazolePivhydrazine may increase the hypoglycemic activities of Sulfamethoxazole.Approved
SulfisoxazolePivhydrazine may increase the hypoglycemic activities of Sulfisoxazole.Approved, Vet Approved
SumatriptanThe metabolism of Sumatriptan can be decreased when combined with Pivhydrazine.Approved, Investigational
SunitinibPivhydrazine may increase the hypoglycemic activities of Sunitinib.Approved, Investigational
TalinololPivhydrazine may increase the hypotensive activities of Talinolol.Investigational
TapentadolThe risk or severity of adverse effects can be increased when Tapentadol is combined with Pivhydrazine.Approved
TelmisartanPivhydrazine may increase the hypotensive activities of Telmisartan.Approved, Investigational
TemocaprilPivhydrazine may increase the hypotensive activities of Temocapril.Experimental, Investigational
TerbutalineThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Terbutaline.Approved
TerlipressinPivhydrazine may increase the hypotensive activities of Terlipressin.Approved, Investigational
Testosterone PropionateThe risk or severity of adverse effects can be increased when Testosterone Propionate is combined with Pivhydrazine.Approved, Vet Approved
TetrabenazineThe risk or severity of adverse effects can be increased when Tetrabenazine is combined with Pivhydrazine.Approved
TetrahydropalmatinePivhydrazine may increase the hypotensive activities of Tetrahydropalmatine.Investigational
TetryzolinePivhydrazine may increase the hypertensive activities of Tetryzoline.Approved
TheodrenalinePivhydrazine may increase the hypotensive activities of Theodrenaline.Investigational
TianeptineThe risk or severity of adverse effects can be increased when Tianeptine is combined with Pivhydrazine.Approved, Investigational
TibolonePivhydrazine may increase the hypotensive activities of Tibolone.Approved, Investigational
TicrynafenPivhydrazine may increase the hypotensive activities of Ticrynafen.Withdrawn
TilidineThe risk or severity of adverse effects can be increased when Tilidine is combined with Pivhydrazine.Experimental
TimololPivhydrazine may increase the hypotensive activities of Timolol.Approved
TolazamidePivhydrazine may increase the hypoglycemic activities of Tolazamide.Approved
TolazolinePivhydrazine may increase the hypotensive activities of Tolazoline.Approved, Vet Approved
TolbutamidePivhydrazine may increase the hypoglycemic activities of Tolbutamide.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Pivhydrazine.Approved, Withdrawn
TolonidinePivhydrazine may increase the hypotensive activities of Tolonidine.Experimental
ToloxatoneToloxatone may increase the hypertensive activities of Pivhydrazine.Approved
TorasemidePivhydrazine may increase the hypotensive activities of Torasemide.Approved
TramadolTramadol may increase the neuroexcitatory activities of Pivhydrazine.Approved, Investigational
TrandolaprilPivhydrazine may increase the hypotensive activities of Trandolapril.Approved
Trans-2-PhenylcyclopropylamineTrans-2-Phenylcyclopropylamine may increase the hypertensive activities of Pivhydrazine.Experimental
TranylcypromineTranylcypromine may increase the hypertensive activities of Pivhydrazine.Approved
TravoprostPivhydrazine may increase the hypotensive activities of Travoprost.Approved
TrazodoneThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Trazodone.Approved, Investigational
TreprostinilPivhydrazine may increase the hypotensive activities of Treprostinil.Approved, Investigational
TrichlormethiazidePivhydrazine may increase the hypotensive activities of Trichlormethiazide.Approved, Vet Approved
TrimazosinPivhydrazine may increase the hypotensive activities of Trimazosin.Experimental
TrimethaphanPivhydrazine may increase the hypotensive activities of Trimethaphan.Approved, Investigational
TrimipraminePivhydrazine may increase the serotonergic activities of Trimipramine.Approved
UnoprostonePivhydrazine may increase the hypotensive activities of Unoprostone.Approved
UrapidilPivhydrazine may increase the hypotensive activities of Urapidil.Investigational
ValsartanPivhydrazine may increase the hypotensive activities of Valsartan.Approved, Investigational
VenlafaxinePivhydrazine may increase the serotonergic activities of Venlafaxine.Approved
VilanterolThe risk or severity of adverse effects can be increased when Pivhydrazine is combined with Vilanterol.Approved
VilazodoneThe metabolism of Vilazodone can be decreased when combined with Pivhydrazine.Approved
VincaminePivhydrazine may increase the hypotensive activities of Vincamine.Experimental
VinpocetinePivhydrazine may increase the hypotensive activities of Vinpocetine.Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Pivhydrazine.Approved
XipamidePivhydrazine may increase the hypotensive activities of Xipamide.Experimental
XylometazolinePivhydrazine may increase the hypotensive activities of Xylometazoline.Approved
ZimelidinePivhydrazine may increase the serotonergic activities of Zimelidine.Withdrawn
ZofenoprilPivhydrazine may increase the hypotensive activities of Zofenopril.Experimental
ZolmitriptanThe metabolism of Zolmitriptan can be decreased when combined with Pivhydrazine.Approved, Investigational
Food Interactions
Not Available

References

General References
  1. Herman ZS, Sokola A, Lenartowicz H, Zielinski M, Depta L: The influence of antidepressive drugs on the level of acetylcholine and on the acetylcholinesterase activity in the brain of rats. Pol J Pharmacol Pharm. 1976 May-Jun;28(4):313-21. [PubMed:981020]
  2. Bolton GC, Griffiths LA: The metabolic disposition of [14C]pivhydrazine, [14C]mebanazine, and [14C]benzylhydrazine in the rat. Drug Metab Dispos. 1979 Nov-Dec;7(6):388-92. [PubMed:43225]
  3. Mikhailova TV, Gilev AP, Khavronina-Gureeva ZP: [Central effects of betamezide]. Farmakol Toksikol. 1969 Nov-Dec;32(6):652-6. [PubMed:5381593]
External Links
PubChem Compound
9375
PubChem Substance
310265155
ChemSpider
9007
ChEBI
134868
ChEMBL
CHEMBL2106941
Wikipedia
Pivhydrazine

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.33 mg/mLALOGPS
logP1.77ALOGPS
logP2.42ChemAxon
logS-2.8ALOGPS
pKa (Strongest Acidic)12.91ChemAxon
pKa (Strongest Basic)3.41ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area41.13 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity71.59 m3·mol-1ChemAxon
Polarizability23.28 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as benzene and substituted derivatives. These are aromatic compounds containing one monocyclic ring system consisting of benzene.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Not Available
Direct Parent
Benzene and substituted derivatives
Alternative Parents
Carboxylic acid hydrazides / Organopnictogen compounds / Organonitrogen compounds / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
Substituents
Monocyclic benzene moiety / Carboxylic acid hydrazide / Carboxylic acid derivative / Organic nitrogen compound / Organic oxygen compound / Organopnictogen compound / Organic oxide / Hydrocarbon derivative / Organooxygen compound / Organonitrogen compound
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
Not Available

Drug created on October 23, 2015 22:15 / Updated on December 01, 2017 16:14