Caroxazone

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Caroxazone
Accession Number
DB09254
Type
Small Molecule
Groups
Withdrawn
Description

Caroxazone (Surodil, Timostenil) is an antidepressant which was formerly used for the treatment of depression but is now no longer marketed. It acts as a reversible monoamine oxidase inhibitor (MAOI) of both MAO-A and MAO-B subtypes, with five-fold preference for the latter.

Structure
Thumb
Synonyms
Not Available
External IDs
F.I. 6654
International/Other Brands
Surodil / Timostenil
Categories
UNII
807N226MNL
CAS number
18464-39-6
Weight
Average: 206.201
Monoisotopic: 206.06914219
Chemical Formula
C10H10N2O3
InChI Key
KYCBWEZLKCTALM-UHFFFAOYSA-N
InChI
InChI=1S/C10H10N2O3/c11-9(13)6-12-5-7-3-1-2-4-8(7)15-10(12)14/h1-4H,5-6H2,(H2,11,13)
IUPAC Name
2-(2-oxo-3,4-dihydro-2H-1,3-benzoxazin-3-yl)acetamide
SMILES
NC(=O)CN1CC2=CC=CC=C2OC1=O

Pharmacology

Indication

For the treatment of depression.

Structured Indications
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
2,5-Dimethoxy-4-ethylamphetamineCaroxazone may increase the hypertensive activities of 2,5-Dimethoxy-4-ethylamphetamine.Experimental, Illicit
3,4-MethylenedioxyamphetamineCaroxazone may increase the hypertensive activities of 3,4-Methylenedioxyamphetamine.Experimental, Illicit
4-Bromo-2,5-dimethoxyamphetamineCaroxazone may increase the hypertensive activities of 4-Bromo-2,5-dimethoxyamphetamine.Experimental, Illicit
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline may increase the hypertensive activities of Caroxazone.Experimental
AcarboseCaroxazone may increase the hypoglycemic activities of Acarbose.Approved, Investigational
AcebutololCaroxazone may increase the hypotensive activities of Acebutolol.Approved
AlaproclateThe risk or severity of adverse effects can be increased when Alaproclate is combined with Caroxazone.Experimental
AlbiglutideCaroxazone may increase the hypoglycemic activities of Albiglutide.Approved
AlfentanilAlfentanil may increase the serotonergic activities of Caroxazone.Approved, Illicit
AliskirenCaroxazone may increase the hypotensive activities of Aliskiren.Approved, Investigational
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Caroxazone.Approved, Investigational
AlogliptinCaroxazone may increase the hypoglycemic activities of Alogliptin.Approved
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Caroxazone.Experimental, Illicit
AlphaprodineThe risk or severity of adverse effects can be increased when Alphaprodine is combined with Caroxazone.Illicit
AlprenololCaroxazone may increase the hypotensive activities of Alprenolol.Approved, Withdrawn
AltretamineAltretamine may increase the orthostatic hypotensive activities of Caroxazone.Approved
AmbrisentanCaroxazone may increase the hypotensive activities of Ambrisentan.Approved, Investigational
AmineptineCaroxazone may increase the serotonergic activities of Amineptine.Illicit, Withdrawn
AmitriptylineCaroxazone may increase the serotonergic activities of Amitriptyline.Approved
AmlodipineCaroxazone may increase the hypotensive activities of Amlodipine.Approved
AmoxapineThe risk or severity of adverse effects can be increased when Caroxazone is combined with Amoxapine.Approved
AmphetamineCaroxazone may increase the hypertensive activities of Amphetamine.Approved, Illicit
ApomorphineThe metabolism of Apomorphine can be decreased when combined with Caroxazone.Approved, Investigational
ApraclonidineThe risk or severity of adverse effects can be increased when Caroxazone is combined with Apraclonidine.Approved
ArbutamineThe risk or severity of adverse effects can be increased when Caroxazone is combined with Arbutamine.Approved
ArformoterolThe risk or severity of adverse effects can be increased when Caroxazone is combined with Arformoterol.Approved, Investigational
AtenololCaroxazone may increase the hypotensive activities of Atenolol.Approved
AtomoxetineCaroxazone may increase the central neurotoxic activities of Atomoxetine.Approved
AtropineCaroxazone may increase the hypertensive activities of Atropine.Approved, Vet Approved
BambuterolThe risk or severity of adverse effects can be increased when Caroxazone is combined with Bambuterol.Approved, Investigational
BenazeprilCaroxazone may increase the hypotensive activities of Benazepril.Approved, Investigational
BendroflumethiazideCaroxazone may increase the hypotensive activities of Bendroflumethiazide.Approved
BenmoxinBenmoxin may increase the hypertensive activities of Caroxazone.Withdrawn
BenzphetamineCaroxazone may increase the hypertensive activities of Benzphetamine.Approved, Illicit
BepridilCaroxazone may increase the hypotensive activities of Bepridil.Approved, Withdrawn
BetahistineThe serum concentration of Betahistine can be increased when it is combined with Caroxazone.Approved
BetaxololCaroxazone may increase the hypotensive activities of Betaxolol.Approved
BethanidineCaroxazone may increase the hypotensive activities of Bethanidine.Approved
BezafibrateThe risk or severity of adverse effects can be increased when Caroxazone is combined with Bezafibrate.Approved
BietaserpineCaroxazone may increase the hypotensive activities of Bietaserpine.Experimental
BimatoprostCaroxazone may increase the hypotensive activities of Bimatoprost.Approved, Investigational
BisoprololCaroxazone may increase the hypotensive activities of Bisoprolol.Approved
BosentanCaroxazone may increase the hypotensive activities of Bosentan.Approved, Investigational
BQ-123Caroxazone may increase the hypotensive activities of BQ-123.Investigational
BretyliumCaroxazone may increase the hypotensive activities of Bretylium.Approved
BrimonidineThe risk or severity of adverse effects can be increased when Caroxazone is combined with Brimonidine.Approved
BrofaromineBrofaromine may increase the hypertensive activities of Caroxazone.Experimental
BromocriptineCaroxazone may increase the hypoglycemic activities of Bromocriptine.Approved, Investigational
BupranololCaroxazone may increase the hypotensive activities of Bupranolol.Approved
BuprenorphineThe risk or severity of adverse effects can be increased when Buprenorphine is combined with Caroxazone.Approved, Illicit, Investigational, Vet Approved
BupropionCaroxazone may increase the hypertensive activities of Bupropion.Approved
BuspironeThe risk or severity of adverse effects can be increased when Buspirone is combined with Caroxazone.Approved, Investigational
ButorphanolThe risk or severity of adverse effects can be increased when Butorphanol is combined with Caroxazone.Approved, Illicit, Vet Approved
CabergolineThe metabolism of Cabergoline can be decreased when combined with Caroxazone.Approved
CadralazineCaroxazone may increase the hypotensive activities of Cadralazine.Experimental
CafedrineCaroxazone may increase the hypotensive activities of Cafedrine.Investigational
CanagliflozinCaroxazone may increase the hypoglycemic activities of Canagliflozin.Approved
CandesartanCaroxazone may increase the hypotensive activities of Candesartan.Experimental
Candesartan cilexetilCaroxazone may increase the hypotensive activities of Candesartan cilexetil.Approved
CandoxatrilCaroxazone may increase the hypotensive activities of Candoxatril.Experimental
CaptoprilCaroxazone may increase the hypotensive activities of Captopril.Approved
CarbamazepineThe risk or severity of adverse effects can be increased when Carbamazepine is combined with Caroxazone.Approved, Investigational
CarfentanilThe risk or severity of adverse effects can be increased when Carfentanil is combined with Caroxazone.Illicit, Investigational, Vet Approved
CarteololCaroxazone may increase the hypotensive activities of Carteolol.Approved
CarvedilolCaroxazone may increase the hypotensive activities of Carvedilol.Approved, Investigational
CeliprololCaroxazone may increase the hypotensive activities of Celiprolol.Approved, Investigational
ChlorothiazideCaroxazone may increase the hypotensive activities of Chlorothiazide.Approved, Vet Approved
ChlorphentermineCaroxazone may increase the hypertensive activities of Chlorphentermine.Illicit, Withdrawn
ChlorpropamideCaroxazone may increase the hypoglycemic activities of Chlorpropamide.Approved
ChlorthalidoneCaroxazone may increase the hypotensive activities of Chlorthalidone.Approved
CicletanineCaroxazone may increase the hypotensive activities of Cicletanine.Investigational
CilazaprilCaroxazone may increase the hypotensive activities of Cilazapril.Approved
CirazolineCaroxazone may increase the hypertensive activities of Cirazoline.Experimental
CitalopramCaroxazone may increase the serotonergic activities of Citalopram.Approved
ClemastineCaroxazone may increase the anticholinergic activities of Clemastine.Approved
ClenbuterolThe risk or severity of adverse effects can be increased when Caroxazone is combined with Clenbuterol.Approved, Investigational, Vet Approved
ClomipramineCaroxazone may increase the serotonergic activities of Clomipramine.Approved, Vet Approved
ClonidineCaroxazone may increase the hypotensive activities of Clonidine.Approved
CloranololCaroxazone may increase the hypotensive activities of Cloranolol.Experimental
CodeineThe risk or severity of adverse effects can be increased when Codeine is combined with Caroxazone.Approved, Illicit
CryptenamineCaroxazone may increase the hypotensive activities of Cryptenamine.Approved
CyclobenzaprineCyclobenzaprine may increase the serotonergic activities of Caroxazone.Approved
CyclopenthiazideCaroxazone may increase the hypotensive activities of Cyclopenthiazide.Experimental
CyclothiazideCaroxazone may increase the hypotensive activities of Cyclothiazide.Approved
CyproheptadineCaroxazone may increase the anticholinergic activities of Cyproheptadine.Approved
DapagliflozinCaroxazone may increase the hypoglycemic activities of Dapagliflozin.Approved
DapoxetineCaroxazone may increase the serotonergic activities of Dapoxetine.Investigational
DebrisoquinCaroxazone may increase the hypotensive activities of Debrisoquin.Approved, Investigational
DelaprilCaroxazone may increase the hypotensive activities of Delapril.Experimental
DeserpidineCaroxazone may increase the hypotensive activities of Deserpidine.Approved
DesipramineCaroxazone may increase the serotonergic activities of Desipramine.Approved
DesvenlafaxineCaroxazone may increase the serotonergic activities of Desvenlafaxine.Approved
DexmethylphenidateCaroxazone may increase the hypertensive activities of Dexmethylphenidate.Approved
DextroamphetamineCaroxazone may increase the hypertensive activities of Dextroamphetamine.Approved, Illicit
DextromethorphanCaroxazone may increase the serotonergic activities of Dextromethorphan.Approved
DextromoramideThe risk or severity of adverse effects can be increased when Dextromoramide is combined with Caroxazone.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Caroxazone.Approved, Illicit, Investigational, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Dezocine is combined with Caroxazone.Approved, Investigational
DiazoxideCaroxazone may increase the hypotensive activities of Diazoxide.Approved
DibenzepinCaroxazone may increase the serotonergic activities of Dibenzepin.Experimental
diethylnorspermineCaroxazone may increase the hypotensive activities of diethylnorspermine.Investigational
DiethylpropionCaroxazone may increase the hypertensive activities of Diethylpropion.Approved, Illicit
DihydralazineCaroxazone may increase the hypotensive activities of Dihydralazine.Investigational
DihydrocodeineThe risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Caroxazone.Approved, Illicit
DihydroergotamineThe metabolism of Dihydroergotamine can be decreased when combined with Caroxazone.Approved
DihydroetorphineThe risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Caroxazone.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Dihydromorphine is combined with Caroxazone.Experimental, Illicit
DiltiazemCaroxazone may increase the hypotensive activities of Diltiazem.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Diphenoxylate is combined with Caroxazone.Approved, Illicit
DipivefrinThe risk or severity of adverse effects can be increased when Caroxazone is combined with Dipivefrin.Approved
DisopyramideCaroxazone may increase the hypoglycemic activities of Disopyramide.Approved
DobutamineThe risk or severity of adverse effects can be increased when Caroxazone is combined with Dobutamine.Approved
DomperidoneThe risk or severity of adverse effects can be increased when Caroxazone is combined with Domperidone.Approved, Investigational, Vet Approved
DorzolamideCaroxazone may increase the hypotensive activities of Dorzolamide.Approved
DosulepinCaroxazone may increase the serotonergic activities of Dosulepin.Approved
DoxapramCaroxazone may increase the hypertensive activities of Doxapram.Approved, Vet Approved
DoxazosinCaroxazone may increase the hypotensive activities of Doxazosin.Approved
DoxepinCaroxazone may increase the serotonergic activities of Doxepin.Approved
DoxylamineCaroxazone may increase the anticholinergic activities of Doxylamine.Approved, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when DPDPE is combined with Caroxazone.Experimental
DrotebanolThe risk or severity of adverse effects can be increased when Drotebanol is combined with Caroxazone.Experimental, Illicit
DroxidopaThe risk or severity of adverse effects can be increased when Caroxazone is combined with Droxidopa.Approved, Investigational
DulaglutideCaroxazone may increase the hypoglycemic activities of Dulaglutide.Approved
DuloxetineCaroxazone may increase the serotonergic activities of Duloxetine.Approved
EcgonineThe risk or severity of adverse effects can be increased when Ecgonine is combined with Caroxazone.Experimental, Illicit
EfonidipineCaroxazone may increase the hypotensive activities of Efonidipine.Approved, Investigational
EletriptanThe metabolism of Eletriptan can be decreased when combined with Caroxazone.Approved, Investigational
EmpagliflozinCaroxazone may increase the hypoglycemic activities of Empagliflozin.Approved
EnalaprilCaroxazone may increase the hypotensive activities of Enalapril.Approved, Vet Approved
EnalaprilatCaroxazone may increase the hypotensive activities of Enalaprilat.Approved
EndralazineCaroxazone may increase the hypotensive activities of Endralazine.Experimental
EntacaponeThe risk or severity of adverse effects can be increased when Entacapone is combined with Caroxazone.Approved, Investigational
EpanololCaroxazone may increase the hypotensive activities of Epanolol.Experimental
EphedraThe risk or severity of adverse effects can be increased when Caroxazone is combined with Ephedra.Approved, Nutraceutical, Withdrawn
EpinephrineCaroxazone may increase the hypertensive activities of Epinephrine.Approved, Vet Approved
EpoprostenolCaroxazone may increase the hypotensive activities of Epoprostenol.Approved
EprosartanCaroxazone may increase the hypotensive activities of Eprosartan.Approved
ErgotamineCaroxazone may increase the hypertensive activities of Ergotamine.Approved
EscitalopramCaroxazone may increase the serotonergic activities of Escitalopram.Approved, Investigational
EsmirtazapineCaroxazone may increase the serotonergic activities of Esmirtazapine.Investigational
EthanolThe risk or severity of adverse effects can be increased when Ethanol is combined with Caroxazone.Approved
EthylmorphineThe risk or severity of adverse effects can be increased when Ethylmorphine is combined with Caroxazone.Approved, Illicit
EtoperidoneCaroxazone may increase the serotonergic activities of Etoperidone.Withdrawn
EtorphineThe risk or severity of adverse effects can be increased when Etorphine is combined with Caroxazone.Illicit, Vet Approved
ExenatideCaroxazone may increase the hypoglycemic activities of Exenatide.Approved, Investigational
FelodipineCaroxazone may increase the hypotensive activities of Felodipine.Approved, Investigational
FenfluramineThe risk or severity of adverse effects can be increased when Caroxazone is combined with Fenfluramine.Illicit, Investigational, Withdrawn
FenoldopamCaroxazone may increase the hypotensive activities of Fenoldopam.Approved
FenoterolThe risk or severity of adverse effects can be increased when Caroxazone is combined with Fenoterol.Approved, Investigational
FentanylFentanyl may increase the serotonergic activities of Caroxazone.Approved, Illicit, Investigational, Vet Approved
Ferulic acidCaroxazone may increase the hypotensive activities of Ferulic acid.Experimental
FluoxetineCaroxazone may increase the serotonergic activities of Fluoxetine.Approved, Vet Approved
FluvoxamineCaroxazone may increase the serotonergic activities of Fluvoxamine.Approved, Investigational
FormoterolThe risk or severity of adverse effects can be increased when Caroxazone is combined with Formoterol.Approved, Investigational
FosinoprilCaroxazone may increase the hypotensive activities of Fosinopril.Approved
FrovatriptanThe metabolism of Frovatriptan can be decreased when combined with Caroxazone.Approved, Investigational
FurazolidoneFurazolidone may increase the hypertensive activities of Caroxazone.Approved, Investigational, Vet Approved
GepefrineThe risk or severity of adverse effects can be increased when Gepefrine is combined with Caroxazone.Experimental
GliclazideCaroxazone may increase the hypoglycemic activities of Gliclazide.Approved
GlimepirideCaroxazone may increase the hypoglycemic activities of Glimepiride.Approved
GlipizideCaroxazone may increase the hypoglycemic activities of Glipizide.Approved
GlyburideCaroxazone may increase the hypoglycemic activities of Glyburide.Approved
GuanabenzCaroxazone may increase the hypotensive activities of Guanabenz.Approved, Investigational
GuanadrelCaroxazone may increase the hypotensive activities of Guanadrel.Approved
GuanazodineCaroxazone may increase the hypotensive activities of Guanazodine.Experimental
GuanethidineCaroxazone may increase the hypotensive activities of Guanethidine.Approved
GuanfacineCaroxazone may increase the hypotensive activities of Guanfacine.Approved, Investigational
GuanoclorCaroxazone may increase the hypotensive activities of Guanoclor.Experimental
GuanoxabenzCaroxazone may increase the hypotensive activities of Guanoxabenz.Experimental
GuanoxanCaroxazone may increase the hypotensive activities of Guanoxan.Experimental
HarmalineHarmaline may increase the hypertensive activities of Caroxazone.Experimental
HeroinThe risk or severity of adverse effects can be increased when Heroin is combined with Caroxazone.Approved, Illicit, Investigational
HexamethoniumCaroxazone may increase the hypotensive activities of Hexamethonium.Experimental
HydracarbazineHydracarbazine may increase the hypertensive activities of Caroxazone.Experimental
HydralazineCaroxazone may increase the hypotensive activities of Hydralazine.Approved
HydrochlorothiazideCaroxazone may increase the hypotensive activities of Hydrochlorothiazide.Approved, Vet Approved
HydrocodoneThe risk or severity of adverse effects can be increased when Caroxazone is combined with Hydrocodone.Approved, Illicit
HydroflumethiazideCaroxazone may increase the hypotensive activities of Hydroflumethiazide.Approved, Investigational
HydromorphoneThe risk or severity of adverse effects can be increased when Caroxazone is combined with Hydromorphone.Approved, Illicit
HydroxyamphetamineCaroxazone may increase the hypertensive activities of Hydroxyamphetamine.Approved
ImidaprilCaroxazone may increase the hypotensive activities of Imidapril.Investigational
ImipramineCaroxazone may increase the serotonergic activities of Imipramine.Approved
IndacaterolThe risk or severity of adverse effects can be increased when Caroxazone is combined with Indacaterol.Approved
IndalpineCaroxazone may increase the serotonergic activities of Indalpine.Investigational, Withdrawn
IndapamideCaroxazone may increase the hypotensive activities of Indapamide.Approved
IndenololCaroxazone may increase the hypotensive activities of Indenolol.Withdrawn
IndoraminCaroxazone may increase the hypotensive activities of Indoramin.Withdrawn
Insulin AspartCaroxazone may increase the hypoglycemic activities of Insulin Aspart.Approved
Insulin DetemirCaroxazone may increase the hypoglycemic activities of Insulin Detemir.Approved
Insulin GlargineCaroxazone may increase the hypoglycemic activities of Insulin Glargine.Approved
Insulin GlulisineCaroxazone may increase the hypoglycemic activities of Insulin Glulisine.Approved
Insulin HumanCaroxazone may increase the hypoglycemic activities of Insulin Human.Approved, Investigational
Insulin LisproCaroxazone may increase the hypoglycemic activities of Insulin Lispro.Approved
Iofetamine I-123The risk or severity of adverse effects can be increased when Iofetamine I-123 is combined with Caroxazone.Approved
IprindoleCaroxazone may increase the serotonergic activities of Iprindole.Experimental
IproclozideIproclozide may increase the hypertensive activities of Caroxazone.Withdrawn
IproniazidIproniazid may increase the hypertensive activities of Caroxazone.Withdrawn
IrbesartanCaroxazone may increase the hypotensive activities of Irbesartan.Approved, Investigational
IsocarboxazidIsocarboxazid may increase the hypertensive activities of Caroxazone.Approved
IsoetarineThe risk or severity of adverse effects can be increased when Caroxazone is combined with Isoetarine.Approved
IsomethepteneThe risk or severity of adverse effects can be increased when Caroxazone is combined with Isometheptene.Approved
IsoprenalineThe risk or severity of adverse effects can be increased when Caroxazone is combined with Isoprenaline.Approved
IsradipineCaroxazone may increase the hypotensive activities of Isradipine.Approved
KetanserinCaroxazone may increase the hypotensive activities of Ketanserin.Investigational
KetobemidoneThe risk or severity of adverse effects can be increased when Ketobemidone is combined with Caroxazone.Approved, Investigational
L-TryptophanThe risk or severity of adverse effects can be increased when L-Tryptophan is combined with Caroxazone.Approved, Nutraceutical, Withdrawn
LabetalolCaroxazone may increase the hypotensive activities of Labetalol.Approved
LacidipineCaroxazone may increase the hypotensive activities of Lacidipine.Approved, Investigational
LatanoprostCaroxazone may increase the hypotensive activities of Latanoprost.Approved, Investigational
LercanidipineCaroxazone may increase the hypotensive activities of Lercanidipine.Approved, Investigational
LevodopaThe risk or severity of adverse effects can be increased when Levodopa is combined with Caroxazone.Approved
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Levomethadyl Acetate is combined with Caroxazone.Approved, Investigational
LevomilnacipranCaroxazone may increase the serotonergic activities of Levomilnacipran.Approved
LevonordefrinCaroxazone may increase the hypertensive activities of Levonordefrin.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Levorphanol is combined with Caroxazone.Approved
LevosalbutamolThe risk or severity of adverse effects can be increased when Caroxazone is combined with Levosalbutamol.Approved
LinezolidThe risk or severity of adverse effects can be increased when Caroxazone is combined with Linezolid.Approved, Investigational
LinsidomineCaroxazone may increase the hypotensive activities of Linsidomine.Experimental
LiraglutideCaroxazone may increase the hypoglycemic activities of Liraglutide.Approved
LisdexamfetamineCaroxazone may increase the hypertensive activities of Lisdexamfetamine.Approved, Investigational
LisinoprilCaroxazone may increase the hypotensive activities of Lisinopril.Approved, Investigational
LisurideThe metabolism of Lisuride can be decreased when combined with Caroxazone.Approved, Investigational
LithiumThe risk or severity of adverse effects can be increased when Caroxazone is combined with Lithium.Approved
LofentanilThe risk or severity of adverse effects can be increased when Lofentanil is combined with Caroxazone.Illicit
LofepramineCaroxazone may increase the serotonergic activities of Lofepramine.Experimental
LofexidineCaroxazone may increase the hypotensive activities of Lofexidine.Approved, Investigational
LosartanCaroxazone may increase the hypotensive activities of Losartan.Approved
MacitentanCaroxazone may increase the hypotensive activities of Macitentan.Approved
ManidipineCaroxazone may increase the hypotensive activities of Manidipine.Approved, Investigational
MaprotilineThe risk or severity of adverse effects can be increased when Maprotiline is combined with Caroxazone.Approved
MebanazineMebanazine may increase the hypertensive activities of Caroxazone.Withdrawn
MecamylamineCaroxazone may increase the hypotensive activities of Mecamylamine.Approved
MecaserminCaroxazone may increase the hypoglycemic activities of Mecasermin.Approved, Investigational
MephedroneCaroxazone may increase the hypertensive activities of Mephedrone.Investigational
MephentermineCaroxazone may increase the hypertensive activities of Mephentermine.Approved
MeptazinolThe risk or severity of adverse effects can be increased when Meptazinol is combined with Caroxazone.Experimental
MequitazineCaroxazone may increase the anticholinergic activities of Mequitazine.Approved
MetaraminolCaroxazone may increase the hypertensive activities of Metaraminol.Approved, Investigational
MetforminCaroxazone may increase the hypoglycemic activities of Metformin.Approved
MethadoneThe risk or severity of adverse effects can be increased when Caroxazone is combined with Methadone.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Methadyl Acetate is combined with Caroxazone.Approved, Illicit
MethamphetamineCaroxazone may increase the hypertensive activities of Methamphetamine.Approved, Illicit
MethoserpidineCaroxazone may increase the hypotensive activities of Methoserpidine.Experimental
MethoxamineCaroxazone may increase the hypertensive activities of Methoxamine.Approved, Investigational
MethoxyphenamineThe risk or severity of adverse effects can be increased when Methoxyphenamine is combined with Caroxazone.Experimental
MethyldopaThe risk or severity of adverse effects can be increased when Caroxazone is combined with Methyldopa.Approved
MethylecgonineThe risk or severity of adverse effects can be increased when Methylecgonine is combined with Caroxazone.Experimental
Methylene blueCaroxazone may increase the serotonergic activities of Methylene blue.Approved, Investigational
MethylphenidateCaroxazone may increase the hypertensive activities of Methylphenidate.Approved, Investigational
MetipranololCaroxazone may increase the hypotensive activities of Metipranolol.Approved
MetolazoneCaroxazone may increase the hypotensive activities of Metolazone.Approved
MetoprololCaroxazone may increase the hypotensive activities of Metoprolol.Approved, Investigational
MetyrosineCaroxazone may increase the hypotensive activities of Metyrosine.Approved
MianserinCaroxazone may increase the neurotoxic activities of Mianserin.Approved, Investigational
MibefradilCaroxazone may increase the hypotensive activities of Mibefradil.Investigational, Withdrawn
MidodrineCaroxazone may increase the hypertensive activities of Midodrine.Approved
MidomafetamineCaroxazone may increase the hypertensive activities of Midomafetamine.Experimental, Illicit, Investigational
MifepristoneCaroxazone may increase the hypoglycemic activities of Mifepristone.Approved, Investigational
MiglitolCaroxazone may increase the hypoglycemic activities of Miglitol.Approved
MilnacipranCaroxazone may increase the serotonergic activities of Milnacipran.Approved
MinaprineMinaprine may increase the hypertensive activities of Caroxazone.Approved
MinoxidilCaroxazone may increase the hypotensive activities of Minoxidil.Approved
MirtazapineCaroxazone may increase the central neurotoxic activities of Mirtazapine.Approved
MMDACaroxazone may increase the hypertensive activities of MMDA.Experimental, Illicit
MoclobemideThe risk or severity of adverse effects can be increased when Caroxazone is combined with Moclobemide.Approved
MoexiprilCaroxazone may increase the hypotensive activities of Moexipril.Approved
MorphineThe risk or severity of adverse effects can be increased when Caroxazone is combined with Morphine.Approved, Investigational
MoxonidineCaroxazone may increase the hypotensive activities of Moxonidine.Approved, Investigational
MuzolimineCaroxazone may increase the hypotensive activities of Muzolimine.Experimental
NadololCaroxazone may increase the hypotensive activities of Nadolol.Approved
NaftopidilCaroxazone may increase the hypotensive activities of Naftopidil.Investigational
NalbuphineThe risk or severity of adverse effects can be increased when Nalbuphine is combined with Caroxazone.Approved
NaratriptanThe metabolism of Naratriptan can be decreased when combined with Caroxazone.Approved, Investigational
NateglinideCaroxazone may increase the hypoglycemic activities of Nateglinide.Approved, Investigational
NebivololCaroxazone may increase the hypotensive activities of Nebivolol.Approved, Investigational
NefazodoneCaroxazone may increase the serotonergic activities of Nefazodone.Approved, Withdrawn
NialamideNialamide may increase the hypertensive activities of Caroxazone.Withdrawn
NicardipineCaroxazone may increase the hypotensive activities of Nicardipine.Approved
NicorandilCaroxazone may increase the hypotensive activities of Nicorandil.Approved, Investigational
NiguldipineCaroxazone may increase the hypotensive activities of Niguldipine.Experimental
NilvadipineCaroxazone may increase the hypotensive activities of Nilvadipine.Approved, Investigational
NimodipineCaroxazone may increase the hypotensive activities of Nimodipine.Approved
NisoldipineCaroxazone may increase the hypotensive activities of Nisoldipine.Approved
NitrendipineCaroxazone may increase the hypotensive activities of Nitrendipine.Approved, Investigational
NitroprussideCaroxazone may increase the hypotensive activities of Nitroprusside.Approved
NorepinephrineCaroxazone may increase the hypertensive activities of Norepinephrine.Approved
NormethadoneThe risk or severity of adverse effects can be increased when Normethadone is combined with Caroxazone.Approved, Illicit
NortriptylineCaroxazone may increase the serotonergic activities of Nortriptyline.Approved
OctamoxinOctamoxin may increase the hypertensive activities of Caroxazone.Withdrawn
OlanzapineThe risk or severity of adverse effects can be increased when Caroxazone is combined with Olanzapine.Approved, Investigational
OlmesartanCaroxazone may increase the hypotensive activities of Olmesartan.Approved, Investigational
OlodaterolThe risk or severity of adverse effects can be increased when Caroxazone is combined with Olodaterol.Approved
OmapatrilatCaroxazone may increase the hypotensive activities of Omapatrilat.Investigational
OpipramolCaroxazone may increase the serotonergic activities of Opipramol.Investigational
OpiumThe risk or severity of adverse effects can be increased when Opium is combined with Caroxazone.Approved, Illicit
OrciprenalineThe risk or severity of adverse effects can be increased when Caroxazone is combined with Orciprenaline.Approved
OxprenololCaroxazone may increase the hypotensive activities of Oxprenolol.Approved
OxycodoneThe risk or severity of adverse effects can be increased when Caroxazone is combined with Oxycodone.Approved, Illicit, Investigational
OxymorphoneThe risk or severity of adverse effects can be increased when Oxymorphone is combined with Caroxazone.Approved, Investigational, Vet Approved
PargylineCaroxazone may increase the hypotensive activities of Pargyline.Approved
ParoxetineCaroxazone may increase the serotonergic activities of Paroxetine.Approved, Investigational
PenbutololCaroxazone may increase the hypotensive activities of Penbutolol.Approved, Investigational
PentamidineCaroxazone may increase the hypoglycemic activities of Pentamidine.Approved
PentazocineThe risk or severity of adverse effects can be increased when Pentazocine is combined with Caroxazone.Approved, Vet Approved
PentoliniumCaroxazone may increase the hypotensive activities of Pentolinium.Approved
PergolideThe metabolism of Pergolide can be decreased when combined with Caroxazone.Approved, Investigational, Vet Approved, Withdrawn
PerindoprilCaroxazone may increase the hypotensive activities of Perindopril.Approved
PethidineCaroxazone may increase the serotonergic activities of Pethidine.Approved
PhenazocineThe risk or severity of adverse effects can be increased when Phenazocine is combined with Caroxazone.Experimental
PhenelzinePhenelzine may increase the hypertensive activities of Caroxazone.Approved
PheniprazinePheniprazine may increase the hypertensive activities of Caroxazone.Withdrawn
PhenoperidineThe risk or severity of adverse effects can be increased when Phenoperidine is combined with Caroxazone.Experimental
PhenoxybenzamineCaroxazone may increase the hypotensive activities of Phenoxybenzamine.Approved
PhenoxypropazinePhenoxypropazine may increase the hypertensive activities of Caroxazone.Withdrawn
PhentermineCaroxazone may increase the hypertensive activities of Phentermine.Approved, Illicit
PhentolamineCaroxazone may increase the hypotensive activities of Phentolamine.Approved
PhenylephrineCaroxazone may increase the hypertensive activities of Phenylephrine.Approved
PhenylpropanolamineThe risk or severity of adverse effects can be increased when Caroxazone is combined with Phenylpropanolamine.Approved, Vet Approved, Withdrawn
PholcodinePholcodine may increase the serotonergic activities of Caroxazone.Approved, Illicit
PiclozotanThe metabolism of Piclozotan can be decreased when combined with Caroxazone.Investigational
PinacidilCaroxazone may increase the hypotensive activities of Pinacidil.Withdrawn
PindololCaroxazone may increase the hypotensive activities of Pindolol.Approved
PioglitazoneCaroxazone may increase the hypoglycemic activities of Pioglitazone.Approved, Investigational
PirbuterolThe risk or severity of adverse effects can be increased when Caroxazone is combined with Pirbuterol.Approved
PiritramideThe risk or severity of adverse effects can be increased when Piritramide is combined with Caroxazone.Investigational
PirlindolePirlindole may increase the hypertensive activities of Caroxazone.Approved
PivhydrazinePivhydrazine may increase the hypertensive activities of Caroxazone.Withdrawn
PizotifenCaroxazone may increase the anticholinergic activities of Pizotifen.Approved
Platelet Activating FactorCaroxazone may increase the hypotensive activities of Platelet Activating Factor.Experimental
PolythiazideCaroxazone may increase the hypotensive activities of Polythiazide.Approved
PramlintideCaroxazone may increase the hypoglycemic activities of Pramlintide.Approved, Investigational
PrazosinCaroxazone may increase the hypotensive activities of Prazosin.Approved
ProcarbazineProcarbazine may increase the hypertensive activities of Caroxazone.Approved
ProcaterolThe risk or severity of adverse effects can be increased when Caroxazone is combined with Procaterol.Approved, Investigational
PropranololCaroxazone may increase the hypotensive activities of Propranolol.Approved, Investigational
ProtriptylineCaroxazone may increase the serotonergic activities of Protriptyline.Approved
PRX-00023The metabolism of PRX-00023 can be decreased when combined with Caroxazone.Investigational
PseudoephedrineCaroxazone may increase the hypertensive activities of Pseudoephedrine.Approved
QuinaprilCaroxazone may increase the hypotensive activities of Quinapril.Approved, Investigational
QuinineCaroxazone may increase the hypoglycemic activities of Quinine.Approved
RamiprilCaroxazone may increase the hypotensive activities of Ramipril.Approved
RasagilineRasagiline may increase the hypertensive activities of Caroxazone.Approved
RemifentanilRemifentanil may increase the serotonergic activities of Caroxazone.Approved
RemikirenCaroxazone may increase the hypotensive activities of Remikiren.Approved
RepaglinideCaroxazone may increase the hypoglycemic activities of Repaglinide.Approved, Investigational
RescinnamineCaroxazone may increase the hypotensive activities of Rescinnamine.Approved
ReserpineThe risk or severity of adverse effects can be increased when Caroxazone is combined with Reserpine.Approved, Investigational
RilmenidineCaroxazone may increase the hypotensive activities of Rilmenidine.Investigational
RiociguatCaroxazone may increase the hypotensive activities of Riociguat.Approved
RitobegronCaroxazone may increase the hypertensive activities of Ritobegron.Investigational
RitodrineThe risk or severity of adverse effects can be increased when Caroxazone is combined with Ritodrine.Approved, Investigational
RizatriptanThe metabolism of Rizatriptan can be decreased when combined with Caroxazone.Approved
RopiniroleThe metabolism of Ropinirole can be decreased when combined with Caroxazone.Approved, Investigational
RosiglitazoneCaroxazone may increase the hypoglycemic activities of Rosiglitazone.Approved, Investigational
SafrazineSafrazine may increase the hypertensive activities of Caroxazone.Withdrawn
SalbutamolThe risk or severity of adverse effects can be increased when Caroxazone is combined with Salbutamol.Approved, Vet Approved
SalmeterolThe risk or severity of adverse effects can be increased when Caroxazone is combined with Salmeterol.Approved
SaprisartanCaroxazone may increase the hypotensive activities of Saprisartan.Experimental
SaxagliptinCaroxazone may increase the hypoglycemic activities of Saxagliptin.Approved
SelegilineSelegiline may increase the hypertensive activities of Caroxazone.Approved, Investigational, Vet Approved
SelexipagCaroxazone may increase the hypotensive activities of Selexipag.Approved
SertralineCaroxazone may increase the serotonergic activities of Sertraline.Approved
SitagliptinCaroxazone may increase the hypoglycemic activities of Sitagliptin.Approved, Investigational
SitaxentanCaroxazone may increase the hypotensive activities of Sitaxentan.Approved, Investigational, Withdrawn
SpiraprilCaroxazone may increase the hypotensive activities of Spirapril.Approved
SufentanilSufentanil may increase the serotonergic activities of Caroxazone.Approved, Investigational
SulfadiazineCaroxazone may increase the hypoglycemic activities of Sulfadiazine.Approved, Vet Approved
SulfamethoxazoleCaroxazone may increase the hypoglycemic activities of Sulfamethoxazole.Approved
SulfisoxazoleCaroxazone may increase the hypoglycemic activities of Sulfisoxazole.Approved, Vet Approved
SumatriptanThe metabolism of Sumatriptan can be decreased when combined with Caroxazone.Approved, Investigational
SunitinibCaroxazone may increase the hypoglycemic activities of Sunitinib.Approved, Investigational
TalinololCaroxazone may increase the hypotensive activities of Talinolol.Investigational
TapentadolThe risk or severity of adverse effects can be increased when Tapentadol is combined with Caroxazone.Approved
TelmisartanCaroxazone may increase the hypotensive activities of Telmisartan.Approved, Investigational
TemocaprilCaroxazone may increase the hypotensive activities of Temocapril.Experimental, Investigational
TerbutalineThe risk or severity of adverse effects can be increased when Caroxazone is combined with Terbutaline.Approved
TerlipressinCaroxazone may increase the hypotensive activities of Terlipressin.Approved, Investigational
Testosterone PropionateThe risk or severity of adverse effects can be increased when Testosterone Propionate is combined with Caroxazone.Approved, Vet Approved
TetrabenazineThe risk or severity of adverse effects can be increased when Tetrabenazine is combined with Caroxazone.Approved
TetrahydropalmatineCaroxazone may increase the hypotensive activities of Tetrahydropalmatine.Investigational
TetryzolineCaroxazone may increase the hypertensive activities of Tetryzoline.Approved
TheodrenalineCaroxazone may increase the hypotensive activities of Theodrenaline.Investigational
TianeptineThe risk or severity of adverse effects can be increased when Tianeptine is combined with Caroxazone.Approved, Investigational
TiboloneCaroxazone may increase the hypotensive activities of Tibolone.Approved, Investigational
TicrynafenCaroxazone may increase the hypotensive activities of Ticrynafen.Withdrawn
TilidineThe risk or severity of adverse effects can be increased when Tilidine is combined with Caroxazone.Experimental
TimololCaroxazone may increase the hypotensive activities of Timolol.Approved
TolazamideCaroxazone may increase the hypoglycemic activities of Tolazamide.Approved
TolazolineCaroxazone may increase the hypotensive activities of Tolazoline.Approved, Vet Approved
TolbutamideCaroxazone may increase the hypoglycemic activities of Tolbutamide.Approved
TolcaponeThe risk or severity of adverse effects can be increased when Tolcapone is combined with Caroxazone.Approved, Withdrawn
TolonidineCaroxazone may increase the hypotensive activities of Tolonidine.Experimental
ToloxatoneToloxatone may increase the hypertensive activities of Caroxazone.Approved
TorasemideCaroxazone may increase the hypotensive activities of Torasemide.Approved
TramadolTramadol may increase the neuroexcitatory activities of Caroxazone.Approved, Investigational
TrandolaprilCaroxazone may increase the hypotensive activities of Trandolapril.Approved
Trans-2-PhenylcyclopropylamineTrans-2-Phenylcyclopropylamine may increase the hypertensive activities of Caroxazone.Experimental
TranylcypromineTranylcypromine may increase the hypertensive activities of Caroxazone.Approved
TravoprostCaroxazone may increase the hypotensive activities of Travoprost.Approved
TrazodoneThe risk or severity of adverse effects can be increased when Caroxazone is combined with Trazodone.Approved, Investigational
TreprostinilCaroxazone may increase the hypotensive activities of Treprostinil.Approved, Investigational
TrichlormethiazideCaroxazone may increase the hypotensive activities of Trichlormethiazide.Approved, Vet Approved
TrimazosinCaroxazone may increase the hypotensive activities of Trimazosin.Experimental
TrimethaphanCaroxazone may increase the hypotensive activities of Trimethaphan.Approved, Investigational
TrimipramineCaroxazone may increase the serotonergic activities of Trimipramine.Approved
UnoprostoneCaroxazone may increase the hypotensive activities of Unoprostone.Approved
UrapidilCaroxazone may increase the hypotensive activities of Urapidil.Investigational
ValsartanCaroxazone may increase the hypotensive activities of Valsartan.Approved, Investigational
VenlafaxineCaroxazone may increase the serotonergic activities of Venlafaxine.Approved
VilanterolThe risk or severity of adverse effects can be increased when Caroxazone is combined with Vilanterol.Approved
VilazodoneThe metabolism of Vilazodone can be decreased when combined with Caroxazone.Approved
VincamineCaroxazone may increase the hypotensive activities of Vincamine.Experimental
VinpocetineCaroxazone may increase the hypotensive activities of Vinpocetine.Investigational
VortioxetineThe metabolism of Vortioxetine can be decreased when combined with Caroxazone.Approved
XipamideCaroxazone may increase the hypotensive activities of Xipamide.Experimental
XylometazolineCaroxazone may increase the hypotensive activities of Xylometazoline.Approved
ZimelidineCaroxazone may increase the serotonergic activities of Zimelidine.Withdrawn
ZofenoprilCaroxazone may increase the hypotensive activities of Zofenopril.Experimental
ZolmitriptanThe metabolism of Zolmitriptan can be decreased when combined with Caroxazone.Approved, Investigational
Food Interactions
Not Available

References

General References
  1. Cecchini S, Petri P, Ardito R, Bareggi SR, Torriti A: A comparative double-blind trial of the new antidepressant caroxazone and amitriptyline. J Int Med Res. 1978;6(5):388-94. [PubMed:359383]
  2. Moretti A, Caccia C, Martini A, Bonollo L, Amico A, Sega R, Nicolella V, Nicolis FB: Effect of caroxazone, a new antidepressant drug, on monoamine oxidases in healthy volunteers. Br J Clin Pharmacol. 1981 May;11(5):511-5. [PubMed:7272163]
External Links
PubChem Compound
29083
PubChem Substance
310265157
ChemSpider
27057
ChEBI
134867
ChEMBL
CHEMBL2104164
Wikipedia
Caroxazone

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility11.9 mg/mLALOGPS
logP-0.25ALOGPS
logP0.12ChemAxon
logS-1.2ALOGPS
pKa (Strongest Acidic)15.42ChemAxon
pKa (Strongest Basic)-4.7ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area72.63 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity52.12 m3·mol-1ChemAxon
Polarizability19.9 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as benzoxazines. These are organic compounds containing a benzene fused to an oxazine ring (a six-membered aliphatic ring with four carbon atoms, one oxygen atom, and one nitrogen atom).
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Benzoxazines
Sub Class
Not Available
Direct Parent
Benzoxazines
Alternative Parents
Alpha amino acids and derivatives / Benzenoids / Carbamate esters / Primary carboxylic acid amides / Organic carbonic acids and derivatives / Oxacyclic compounds / Azacyclic compounds / Organopnictogen compounds / Organonitrogen compounds / Organic oxides
show 2 more
Substituents
Alpha-amino acid or derivatives / Benzoxazine / Benzenoid / Carbamic acid ester / Carboxamide group / Carbonic acid derivative / Primary carboxylic acid amide / Carboxylic acid derivative / Azacycle / Oxacycle
show 9 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available

Drug created on October 23, 2015 22:21 / Updated on December 01, 2017 16:14