Zoalene

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Zoalene
Accession Number
DB11480
Type
Small Molecule
Groups
Experimental, Vet approved
Description

Dinitolmide is a fodder additive for prophylaxis against coccidiosis infections in poultry.

Structure
Thumb
Synonyms
  • Coccidine A
  • Dinitolmida
  • Dinitolmide
  • Dinitolmidum
  • Zoalene
Categories
UNII
AOX68RY4TV
CAS number
148-01-6
Weight
Average: 225.1583
Monoisotopic: 225.038570349
Chemical Formula
C8H7N3O5
InChI Key
ZEFNOZRLAWVAQF-UHFFFAOYSA-N
InChI
InChI=1S/C8H7N3O5/c1-4-6(8(9)12)2-5(10(13)14)3-7(4)11(15)16/h2-3H,1H3,(H2,9,12)
IUPAC Name
2-methyl-3,5-dinitrobenzamide
SMILES
CC1=C(C=C(C=C1C(N)=O)[N+]([O-])=O)[N+]([O-])=O

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
SulpirideThe risk or severity of adverse effects can be increased when Zoalene is combined with Sulpiride.
Additional Data Available
  • Extended Description
    Extended Description

    Extended description of the mechanism of action and particular properties of each drug interaction.

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  • Severity
    Severity

    A severity rating for each drug interaction, from minor to major.

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  • Evidence Level
    Evidence Level

    A rating for the strength of the evidence supporting each drug interaction.

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  • Action
    Action

    An effect category for each drug interaction. Know how this interaction affects the subject drug.

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Food Interactions
Not Available

References

General References
  1. Bigland CH, Howell J, DaMassa AJ: Zoalene toxicity in broiler chickens. Avian Dis. 1963 Nov;7(4):471-80. [PubMed:5888507]
  2. Morawski J, Kyle G: Liquid chromatographic determination of zoalene in medicated feeds. J Assoc Off Anal Chem. 1984 Sep-Oct;67(5):861-2. [PubMed:6501147]
  3. Barefield LA: Qualitative identification of furazolidone, tylosin, and zoalene in feeds. J Assoc Off Anal Chem. 1973 May;56(3):762-4. [PubMed:4779916]
  4. Parks OW: Depletion of the monoamino metabolites of Zoalene during frozen storage. J AOAC Int. 1993 May-Jun;76(3):698-701. [PubMed:8318867]
  5. Burow H, Weiss H: [Experimental zoalene resistance in an Eimeria (E) tenella field strain]. Berl Munch Tierarztl Wochenschr. 1972 Apr 1;85(7):127-32. [PubMed:5032069]
  6. Sokolov GA: [Zoalene for the treatment of lambs with coccidiosis]. Veterinariia. 1967 Mar;44(3):57-8. [PubMed:5630084]
  7. Stuart EE, Bruins HW, Keenum RD: The immunogenicity of a commercial coccidiosis vaccine in conjunction with Trithiadol and Zoalene. Avian Dis. 1963 Feb;7(1):12-8. [PubMed:5888495]
  8. ROSENBERG DW, WOODWARD WD, KLINE AE: Effect of two nitrofurans and zoalene on poultry condemnations due to air sac disease. J Am Vet Med Assoc. 1962 Oct 15;141:958-9. [PubMed:13974888]
  9. Leibetseder J: [Studies on the harmlessness to health of 3,5-dinitro-o-toluylamide (Zoalene) in laying hen feed]. Wien Tierarztl Monatsschr. 1968;55(12):761-86. [PubMed:5755965]
  10. Parks OW, Doerr RC: Liquid chromatographic determination of zoalene and its metabolites in chicken tissues with electrochemical detection. J Assoc Off Anal Chem. 1986 Jan-Feb;69(1):70-1. [PubMed:3949706]
  11. Yannai, Shmuel (2003). Dictionary of Food Compounds with : Additives, Flavors, and Ingredients. CRC Press LLC. [ISBN:1584884169]
External Links
Human Metabolome Database
HMDB0032558
KEGG Drug
D07857
ChemSpider
2982
ChEMBL
CHEMBL472565
Wikipedia
Dinitolmide

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.109 mg/mLALOGPS
logP0.73ALOGPS
logP1.22ChemAxon
logS-3.3ALOGPS
pKa (Strongest Acidic)12.37ChemAxon
pKa (Strongest Basic)-0.85ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area129.37 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity52.82 m3·mol-1ChemAxon
Polarizability19.18 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as dinitrotoluenes. These are organic aromatic compounds containing a benzene that carries a single methyl group and exactly two nitro groups.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Toluenes
Direct Parent
Dinitrotoluenes
Alternative Parents
o-Toluamides / Nitrobenzenes / Benzamides / Nitroaromatic compounds / Benzoyl derivatives / Primary carboxylic acid amides / Propargyl-type 1,3-dipolar organic compounds / Organic oxoazanium compounds / Organopnictogen compounds / Organooxygen compounds
show 4 more
Substituents
Dinitrotoluene / Benzamide / Benzoic acid or derivatives / Nitrobenzene / O-toluamide / Toluamide / Nitroaromatic compound / Benzoyl / Carboxamide group / C-nitro compound
show 16 more
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
Not Available

Drug created on February 25, 2016 12:07 / Updated on June 04, 2019 07:22