Tricaine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

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Name
Tricaine
Accession Number
DB11552
Type
Small Molecule
Groups
Vet approved
Description

Tricaine (as tricaine methanesulfonate) is white powder used for anesthesia, sedation, or euthanasia of fish. It is also the only anesthetic licensed in the United States for use in fin fish that are intended for human consumption.

Structure
Thumb
Synonyms
  • Tricaine mesylate
Product Ingredients
IngredientUNIICASInChI Key
Tricaine methanesulfonate971ZM8IPK1886-86-2FQZJYWMRQDKBQN-UHFFFAOYSA-N
International/Other Brands
Finquel
Categories
UNII
02591PHL19
CAS number
582-33-2
Weight
Average: 165.1891
Monoisotopic: 165.078978601
Chemical Formula
C9H11NO2
InChI Key
ZMCBYSBVJIMENC-UHFFFAOYSA-N
InChI
InChI=1S/C9H11NO2/c1-2-12-9(11)7-4-3-5-8(10)6-7/h3-6H,2,10H2,1H3
IUPAC Name
ethyl 3-aminobenzoate
SMILES
CCOC(=O)C1=CC(N)=CC=C1

Pharmacology

Indication
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
2,5-Dimethoxy-4-ethylthioamphetamineThe risk or severity of adverse effects can be increased when Tricaine is combined with 2,5-Dimethoxy-4-ethylthioamphetamine.
4-Bromo-2,5-dimethoxyamphetamineThe risk or severity of adverse effects can be increased when 4-Bromo-2,5-dimethoxyamphetamine is combined with Tricaine.
4-MethoxyamphetamineThe risk or severity of adverse effects can be increased when 4-Methoxyamphetamine is combined with Tricaine.
5-methoxy-N,N-dimethyltryptamineThe risk or severity of adverse effects can be increased when Tricaine is combined with 5-methoxy-N,N-dimethyltryptamine.
7-NitroindazoleThe risk or severity of adverse effects can be increased when 7-Nitroindazole is combined with Tricaine.
7,8-Dichloro-1,2,3,4-tetrahydroisoquinolineThe risk or severity of adverse effects can be increased when 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline is combined with Tricaine.
AcepromazineThe risk or severity of adverse effects can be increased when Acepromazine is combined with Tricaine.
AceprometazineThe risk or severity of adverse effects can be increased when Aceprometazine is combined with Tricaine.
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Tricaine.
AcetophenazineThe risk or severity of adverse effects can be increased when Acetophenazine is combined with Tricaine.
Additional Data Available
  • Extended Description
    Extended Description

    Extended description of the mechanism of action and particular properties of each drug interaction.

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  • Severity
    Severity

    A severity rating for each drug interaction, from minor to major.

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  • Evidence Level
    Evidence Level

    A rating for the strength of the evidence supporting each drug interaction.

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  • Action
    Action

    An effect category for each drug interaction. Know how this interaction affects the subject drug.

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Food Interactions
Not Available

References

General References
  1. Ohr EA: Tricaine methanesulfonate--II. Effects on transport of NaCl and H2O. Comp Biochem Physiol C. 1976;54(1):19-22. [PubMed:6202]
  2. Conroy CJ, Papenfuss T, Parker J, Hahn NE: Use of tricaine methanesulfonate (MS222) for euthanasia of reptiles. J Am Assoc Lab Anim Sci. 2009 Jan;48(1):28-32. [PubMed:19245747]
  3. Ohr EA: Tricaine methanesulfonate--1. pH and its effects on anesthetic potency. Comp Biochem Physiol C. 1976;54(1):13-7. [PubMed:6201]
  4. FRIDDLE SB, SNIESZKO SF: Effect of tricaine methanesulfonate on the determination of sulfonamides. Science. 1950 Aug 11;112(2902):181-2. [PubMed:15442296]
  5. La Touche YD, Kimeldorf DJ: An effect of tricaine methanesulfonate on the electroretinogram of Taricha granulosa. Life Sci. 1978 Feb;22(7):597-602. [PubMed:203816]
  6. Posner LP, Scott GN, Law JM: Repeated exposure of goldfish (Carassius auratus) to tricaine methanesulfonate (MS-222). J Zoo Wildl Med. 2013 Jun;44(2):340-7. [PubMed:23805553]
  7. Wilson JM, Bunte RM, Carty AJ: Evaluation of rapid cooling and tricaine methanesulfonate (MS222) as methods of euthanasia in zebrafish (Danio rerio). J Am Assoc Lab Anim Sci. 2009 Nov;48(6):785-9. [PubMed:19930828]
  8. Hikasa Y, Takase K, Ogasawara T, Ogasawara S: Anesthesia and recovery with tricaine methanesulfonate, eugenol and thiopental sodium in the carp, Cyprinus carpio. Nihon Juigaku Zasshi. 1986 Apr;48(2):341-51. [PubMed:3712895]
  9. Reinitz GL, Rix J: Effect of tricaine methanesulfonate (MS-222) on hematocrit values in rainbow trout (Salmo gairdneri). Comp Biochem Physiol C. 1977;56(2):115-6. [PubMed:15769]
  10. Lalonde-Robert V, Desgent S, Duss S, Vachon P: Electroencephalographic and physiologic changes after tricaine methanesulfonate immersion of African clawed frogs (Xenopus laevis). J Am Assoc Lab Anim Sci. 2012;51(5):622-7. [PubMed:23312092]
External Links
KEGG Drug
D08632
KEGG Compound
C18090
ChemSpider
13860074
ChEBI
81494
ChEMBL
CHEMBL1702228
HET
FG7
Wikipedia
Tricaine_mesylate
PDB Entries
3qih

Clinical Trials

Clinical Trials
Not Available

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility2.5 mg/mLALOGPS
logP2.12ALOGPS
logP1.5ChemAxon
logS-1.8ALOGPS
pKa (Strongest Basic)2.89ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area52.32 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity47.53 m3·mol-1ChemAxon
Polarizability17.66 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on February 26, 2016 10:45 / Updated on September 02, 2019 22:12