Ritobegron

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Ritobegron
DrugBank Accession Number
DB12080
Background

Ritobegron is under investigation in clinical trial NCT02256735 (Study to Investigate the Effect of KUC 7483 CL on the QT/QTc Interval of the ECG in Comparison to Placebo and Moxifloxacin in Healthy Male and Female Volunteers).

Type
Small Molecule
Groups
Investigational
Structure
Weight
Average: 373.449
Monoisotopic: 373.188922973
Chemical Formula
C21H27NO5
Synonyms
  • Ritobegron
External IDs
  • KUC-7483

Pharmacology

Indication

Not Available

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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcebutololThe therapeutic efficacy of Acebutolol can be decreased when used in combination with Ritobegron.
AceclofenacThe risk or severity of hypertension can be increased when Aceclofenac is combined with Ritobegron.
AcemetacinThe risk or severity of hypertension can be increased when Ritobegron is combined with Acemetacin.
AcetazolamideAcetazolamide may decrease the excretion rate of Ritobegron which could result in a higher serum level.
AcetophenazineAcetophenazine may decrease the stimulatory activities of Ritobegron.
Food Interactions
Not Available

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as phenoxyacetic acid derivatives. These are compounds containing an anisole where the methane group is linked to an acetic acid or a derivative.
Kingdom
Organic compounds
Super Class
Benzenoids
Class
Benzene and substituted derivatives
Sub Class
Phenoxyacetic acid derivatives
Direct Parent
Phenoxyacetic acid derivatives
Alternative Parents
Phenethylamines / Phenylpropanes / p-Xylenes / Phenoxy compounds / Phenol ethers / 1-hydroxy-2-unsubstituted benzenoids / Alkyl aryl ethers / Aralkylamines / 1,2-aminoalcohols / Amino acids
show 8 more
Substituents
1,2-aminoalcohol / 1-hydroxy-2-unsubstituted benzenoid / Alcohol / Alkyl aryl ether / Amine / Amino acid / Amino acid or derivatives / Aralkylamine / Aromatic alcohol / Aromatic homomonocyclic compound
show 22 more
Molecular Framework
Aromatic homomonocyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
LD86RKR53M
CAS number
255734-04-4
InChI Key
VMMYRRFPMAGXNP-BTYIYWSLSA-N
InChI
InChI=1S/C21H27NO5/c1-13-11-19(27-12-20(24)25)14(2)10-17(13)8-9-22-15(3)21(26)16-4-6-18(23)7-5-16/h4-7,10-11,15,21-23,26H,8-9,12H2,1-3H3,(H,24,25)/t15-,21-/m0/s1
IUPAC Name
2-[4-(2-{[(1R,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]amino}ethyl)-2,5-dimethylphenoxy]acetic acid
SMILES
C[C@H](NCCC1=C(C)C=C(OCC(O)=O)C(C)=C1)[C@H](O)C1=CC=C(O)C=C1

References

General References
Not Available
PubChem Compound
9820882
PubChem Substance
347828386
ChemSpider
7996631
ChEMBL
CHEMBL2107773
ZINC
ZINC000072266295

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3CompletedTreatmentOveractive Bladder Syndrome (OABS)1
3WithdrawnTreatmentOveractive Bladder Syndrome (OABS)1
2CompletedTreatmentOveractive Bladder Syndrome (OABS)1
1CompletedTreatmentHealthy Volunteers (HV)6
1CompletedTreatmentSpinal Cord Injuries1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0103 mg/mLALOGPS
logP1.79ALOGPS
logP0.9Chemaxon
logS-4.6ALOGPS
pKa (Strongest Acidic)3.73Chemaxon
pKa (Strongest Basic)10.01Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count6Chemaxon
Hydrogen Donor Count4Chemaxon
Polar Surface Area99.02 Å2Chemaxon
Rotatable Bond Count9Chemaxon
Refractivity103.67 m3·mol-1Chemaxon
Polarizability41.25 Å3Chemaxon
Number of Rings2Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0bt9-1129000000-a090e7f8f156f64237e9
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-004i-9001000000-2faedf3f6e798312e282
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-053r-4393000000-06f25d21bc413929a54e
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-004i-8944000000-f681f8c312f297419b63
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-001i-1961000000-443679b85e2e07ec6b5f
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-004i-9000000000-3c11f6cbba4b9c6dae33
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-192.63344
predicted
DeepCCS 1.0 (2019)
[M+H]+194.99144
predicted
DeepCCS 1.0 (2019)
[M+Na]+201.72179
predicted
DeepCCS 1.0 (2019)

Drug created at October 20, 2016 21:19 / Updated at February 21, 2021 18:53