Phenethylamines

A group of compounds that are derivatives of beta- aminoethylbenzene which is structurally and pharmacologically related to amphetamine. (From Merck Index, 11th ed)
DrugDrug NameDrug Indication
DB00182AmphetamineAmphetamine is indicated for the treatment of attention-deficit/hyperactivity disorders (ADHD) as well as for the treatment of central nervous system disorders such as narcolepsy.[A18540] ADHD is a complex disorder associated with the substantial heterogeneity in etiology, clinical presentation, and treatment outcome. ADHD comes from a complex interplay between interdependent genetic and non-genetic factors which cause complex mental disorders in children and teenagers.[A174271] On the other hand, narcolepsy is a chronic sleep disorder typically resenting during adolescence and characterized by excessive daytime sleepiness.[A174274] Amphetamine is also being used nowadays off-label for the treatment of obesity, depression and chronic pain.[A174268, A174283]
DB00191PhenterminePhentermine is indicated, alone or in combination with topiramate, as a short-term adjunct, not pass a few weeks, in a regimen of weight reduction based on exercise, behavioral modifications and caloric restriction in the management of exogenous obesity for patients with an initial body mass index (BMI) greater than 30 kg/m2 or greater than 27 kg/m2 in presence of other risk factors such as controller hypertension, diabetes or hyperlipidemia.[FDA label] Exogenous obesity is considered when the overweight is caused by consuming more food than the person activity level warrants. This condition commonly causes an increase in fat storage. It is an epidemic condition in the United States where over two-thirds of adults are overweight or obese and one in three Americans is obese. In the world, the incidence of obesity has nearly doubled.[A174391]
DB00285VenlafaxineVenlafaxine is indicated in the management of major depressive disorder (MDD), generalized anxiety disorder (GAD), social anxiety disorder (social phobia), and panic disorder with or without agoraphobia. Venlafaxine is also used off-label for prophylaxis of migraine headaches [A177229], for reduction of vasomotor symptoms associated with menopause [A177238], and for management of neuropathic pain (although there is only minimal evidence of efficacy for this condition) [A177232]. It is also considered a second-line option for management of obsessive-compulsive disorder (OCD) [A177226, A177235].
DB00360SapropterinFor the treatment of tetrahydrobiopterin (BH4) deficiency.
DB00574FenfluramineFor the management of exogenous obesity as a short-term (a few weeks) adjunct in a regimen of weight reduction based on caloric restriction.
DB00661VerapamilFor the treatment of hypertension, angina, and cluster headache prophylaxis.
DB00723MethoxamineIndicated for the treatment and management of hypotension.
DB00841DobutamineIndicated when parenteral therapy is necessary for inotropic support in the short-term treatment of patients with cardiac decompensation due to depressed contractility resulting either from organic heart disease or from cardiac surgical procedures.
DB00852PseudoephedrineFor the treatment of nasal congestion, sinus congestion, Eustachian tube congestion, and vasomotor rhinitis, and as an adjunct to other agents in the optimum treatment of allergic rhinitis, croup, sinusitis, otitis media, and tracheobronchitis. Also used as first-line therapy of priapism.
DB00865BenzphetamineFor the management of exogenous obesity as a short term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction
DB00867RitodrineFor the treatment and prophylaxis of premature labour
DB00938SalmeterolFor the treatment of asthma and chronic obstructive pulmonary disease (COPD).
DB01001SalbutamolSalbutamol is indicated for (i) the symptomatic relief and prevention of bronchospasm due to bronchial asthma, chronic bronchitis, reversible obstructive airway disease, and other chronic bronchopulmonary disorders in which bronchospasm is a complicating factor, and/or (ii) the acute prophylaxis against exercise-induced bronchospasm and other stimuli known to induce bronchospasm [FDA Label, F3265, F3268].
DB01037SelegilineMonotherapy for initial treatment of Parkinson's disease, as well as an adjunct therapy in patients with a decreased response to levodopa/carbadopa. Also used for the palliative treatment of mild to moderate Alzheimer's disease and at higher doses, for the treatment of depression.
DB01191DexfenfluramineFor the management of obesity including weight loss and maintenance of weight loss in patients on a reduced calorie diet
DB01255LisdexamfetamineFor the treatment of Attention-deficit/hyperactivity disorder (ADHD) and for moderate to severe binge eating disorder in adults [FDA label], [A40246]. This drug is not indicated for weight loss. Use of other sympathomimetic drugs for weight loss is associated with serious cardiovascular effects. The safety and effectiveness of this drug for the treatment of obesity have not yet been determined [FDA label].
DB01364EphedrineEphedrine commonly used as a stimulant, appetite suppressant, concentration aid, decongestant, and to treat hypotension associated with anaesthesia.
DB01365MephentermineUsed to maintain blood pressure in hypotensive states.
DB01442MMDAMMDA is a recreational drug. It has no current medical uses and is a Schedule I controlled substance in the USA at present.
DB01454MidomafetamineClinical trials are now testing the therapeutic potential of MDMA for post-traumatic stress disorder (PTSD) and anxiety associated with terminal cancer. MDMA is one of the four most widely used illicit drugs in the U.S.
DB014652,5-DimethoxyamphetamineNot Available
DB014672,5-Dimethoxy-4-ethylamphetamineNot Available
DB014724-MethoxyamphetamineNot Available
DB01482FenethyllineNot Available
DB014844-Bromo-2,5-dimethoxyamphetamineNot Available
DB01509TenamfetamineNot Available
DB015374-Bromo-2,5-dimethoxyphenethylamineNot Available
DB01550FenproporexFenproporex is used as an appetite suppressant, and anti-obesity agent [2]; however, due to substance abuse potential, it is an illicit substance in many countries. In some countries, such as Brazil, it is still prescribed -- often in the form of diet pills (ie. Brazilian Diet Pills) which combine amphetamines, benzodiazepines, antidepressants, diuretics and laxatives. In the United States the sale of such diet pills has been banned due to concerns over side effects, and the risk of potentially fatal overdose. However, internet sales and illicit markets has lead to international availability. It has been found by primary care physicians that Brazilian immigrant women utilized imported diet pills at particularly high rates, and sometimes suffered from side effects requiring hospitalization or experienced a loss of employment. [3]
DB01556ChlorphentermineUsed as an appetite suppressant.
DB01576DextroamphetamineDextroamphetamine is indicated for the treatment of attention deficit hyperactivity disorder (ADHD)[Label].
DB01577MetamfetamineFor the treatment of Attention Deficit Disorder with Hyperactivity (ADHD) and exogenous obesity.
DB04825PrenylamineNot Available
DB06152NylidrinNylidrin is mainly indicated in conditions like arteriosclerosis, cerebrovascular disease, peripheral vascular disease, Raynaud's disease, thrombo-angitis obliterans, and thrombophlebitis [L2285]. It may sometimes be used in the treatment of peripheral vascular disorders in addition premature labor (however, the drug is not approved for premature labor)[A32531].
DB08941IsoxsuprineNot Available
DB08957HexoprenalineNot Available
DB08980FendilineNot Available
DB09022BenfluorexNot Available
DB09352HydroxyamphetamineMydriatic agent (eye pupil dilatation) for diagnosis of ophthalmic nerve lesions.
DB09480Iofetamine I-123Not Available
DB11587EtafedrineConditions characterized by bronchial congestion and bronchospasm when an expectorant or bronchodilator action is required, such as acute bronchitis, acute episodes of chronic bronchitis and bronchial asthma [L2565], [L2566].
DB11610OxilofrineUsed in combination with [DB11609] as an antitussive [FDA Label].
DB12080RitobegronNot Available
DB12923GallopamilNot Available
DB13108MephedroneNot Available
DB13139LevosalbutamolIndicated for the management of COPD (chronic obstructive pulmonary disease, also known as chronic obstructive lung disease) and asthma.
DB13251OctopamineNot Available
DB13340SuloctidilNot Available
DB13378NorfenefrineNot Available
DB13398OxyfedrineNot Available
DB13561ClobenzorexNot Available
DB13624MethoxyphenamineNot Available
DB13703GepefrineNot Available
DB13852MefenorexNot Available
DB139402,5-Dimethoxy-4-ethylthioamphetamineNot Available
DB14063DexverapamilNot Available
DB14064EmopamilNot Available
DrugDrug NameTargetType
DB00182AmphetamineSodium-dependent dopamine transportertarget
DB00182AmphetamineCocaine- and amphetamine-regulated transcript proteintarget
DB00182AmphetamineTrace amine-associated receptor 1target
DB00182AmphetamineCytochrome P450 2D6enzyme
DB00182AmphetamineSolute carrier family 22 member 3transporter
DB00182AmphetamineSolute carrier family 22 member 5transporter
DB00182AmphetamineSynaptic vesicular amine transportertarget
DB00182AmphetamineCytochrome P450 2A6enzyme
DB00182AmphetamineSodium-dependent noradrenaline transportertarget
DB00182AmphetamineAlpha adrenergic receptortarget
DB00182AmphetamineBeta adrenergic receptortarget
DB00182AmphetamineD(2) dopamine receptortarget
DB00182AmphetamineAmine oxidase [flavin-containing] Btarget
DB00182AmphetamineSodium-dependent serotonin transportertarget
DB00182AmphetamineMonoamine oxidasetarget
DB00182Amphetaminevesicular monoamine transporter 2 (VMAT2)target
DB00191PhentermineSodium-dependent noradrenaline transportertarget
DB00191PhentermineSodium-dependent dopamine transportertarget
DB00191PhentermineAmine oxidase [flavin-containing] Atarget
DB00191PhentermineAmine oxidase [flavin-containing] Btarget
DB00191PhentermineSodium-dependent serotonin transportertarget
DB00191PhenterminePro-neuropeptide Ytarget
DB00191PhentermineCytochrome P450 3A4enzyme
DB00285VenlafaxineSodium-dependent serotonin transportertarget
DB00285VenlafaxineSodium-dependent noradrenaline transportertarget
DB00285VenlafaxineCytochrome P450 2D6enzyme
DB00285VenlafaxineCytochrome P450 3A4enzyme
DB00285VenlafaxineSodium-dependent dopamine transportertarget
DB00285VenlafaxineMultidrug resistance protein 1transporter
DB00285VenlafaxineATP-binding cassette sub-family G member 2transporter
DB00360SapropterinPhenylalanine-4-hydroxylasetarget
DB00360SapropterinNitric oxide synthase, endothelialtarget
DB00360SapropterinTyrosine 3-monooxygenasetarget
DB00360SapropterinTryptophan 5-hydroxylase 1target
DB00360SapropterinProstaglandin G/H synthase 2enzyme
DB00574Fenfluramine5-hydroxytryptamine receptor 2Ctarget
DB00574Fenfluramine5-hydroxytryptamine receptor 2Btarget
DB00574FenfluramineCytochrome P450 2D6enzyme
DB00574FenfluramineSodium-dependent serotonin transportertarget
DB00574Fenfluramine5-hydroxytryptamine receptor 2Atarget
DB00661VerapamilSodium channel protein type 5 subunit alphatarget
DB00661VerapamilATP-sensitive inward rectifier potassium channel 11target
DB00661VerapamilVoltage-dependent L-type calcium channel subunit beta-4target
DB00661VerapamilVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
DB00661VerapamilVoltage-dependent L-type calcium channel subunit alpha-1Ftarget
DB00661VerapamilVoltage-dependent L-type calcium channel subunit beta-3target
DB00661VerapamilVoltage-dependent L-type calcium channel subunit alpha-1Dtarget
DB00661VerapamilVoltage-dependent L-type calcium channel subunit beta-1target
DB00661VerapamilVoltage-dependent L-type calcium channel subunit beta-2target
DB00661VerapamilPotassium voltage-gated channel subfamily H member 2target
DB00661VerapamilVoltage-dependent L-type calcium channel subunit alpha-1Starget
DB00661VerapamilVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB00661VerapamilVoltage-dependent T-type calcium channel subunit alpha-1Itarget
DB00661VerapamilCytochrome P450 1A2enzyme
DB00661VerapamilCytochrome P450 3A5enzyme
DB00661VerapamilVoltage-dependent N-type calcium channel subunit alpha-1Btarget
DB00661VerapamilVoltage-dependent P/Q-type calcium channel subunit alpha-1Atarget
DB00661VerapamilSodium-dependent serotonin transportertarget
DB00661VerapamilCytochrome P450 3A4enzyme
DB00661VerapamilCytochrome P450 3A7enzyme
DB00661VerapamilMultidrug resistance protein 1transporter
DB00661VerapamilSolute carrier family 22 member 1transporter
DB00661VerapamilCanalicular multispecific organic anion transporter 2transporter
DB00661VerapamilMultidrug resistance-associated protein 4transporter
DB00661VerapamilSolute carrier family 22 member 5transporter
DB00661VerapamilMultidrug resistance-associated protein 1transporter
DB00661VerapamilSolute carrier organic anion transporter family member 1A2transporter
DB00661VerapamilMultidrug resistance-associated protein 7transporter
DB00661VerapamilCanalicular multispecific organic anion transporter 1transporter
DB00661VerapamilSolute carrier family 22 member 4transporter
DB00661VerapamilATP-binding cassette sub-family G member 2transporter
DB00661VerapamilSolute carrier organic anion transporter family member 1B1transporter
DB00661VerapamilCytochrome P450 2C8enzyme
DB00661VerapamilCytochrome P450 2C9enzyme
DB00661VerapamilCytochrome P450 2C18enzyme
DB00661VerapamilCytochrome P450 2B6enzyme
DB00661VerapamilCytochrome P450 2C19enzyme
DB00661VerapamilCytochrome P450 2D6enzyme
DB00661VerapamilAlpha-1A adrenergic receptortarget
DB00661VerapamilAlpha-1B adrenergic receptortarget
DB00661VerapamilAlpha-1D adrenergic receptortarget
DB00661VerapamilBile salt export pumptransporter
DB00723MethoxamineAlpha-1A adrenergic receptortarget
DB00723MethoxamineAlpha-1B adrenergic receptortarget
DB00723MethoxamineAlpha-1D adrenergic receptortarget
DB00841DobutamineBeta-1 adrenergic receptortarget
DB00841DobutamineCatechol O-methyltransferaseenzyme
DB00841DobutamineBeta-2 adrenergic receptortarget
DB00841DobutamineAlpha-1 adrenergic receptorstarget
DB00841DobutamineEstrogen receptor alphatarget
DB00852PseudoephedrineAlpha-1A adrenergic receptortarget
DB00852PseudoephedrineAlpha-2A adrenergic receptortarget
DB00852PseudoephedrineBeta-2 adrenergic receptortarget
DB00852PseudoephedrineAmine oxidase [flavin-containing] Aenzyme
DB00852PseudoephedrineBeta-1 adrenergic receptortarget
DB00852PseudoephedrineCytochrome P450 2D6enzyme
DB00852PseudoephedrineSodium-dependent dopamine transportertarget
DB00852PseudoephedrineSodium-dependent noradrenaline transportertarget
DB00852PseudoephedrineSodium-dependent serotonin transportertarget
DB00852PseudoephedrineNuclear factor of activated T-cells, cytoplasmic 1target
DB00852PseudoephedrineTumor necrosis factortarget
DB00852PseudoephedrineNuclear factor kappa-light-chain-enhancer of activated B cellstarget
DB00852Pseudoephedrineactivator protein 1target
DB00852PseudoephedrineInterleukin-2target
DB00865BenzphetamineAlpha-2A adrenergic receptortarget
DB00865BenzphetamineAlpha-1A adrenergic receptortarget
DB00865BenzphetamineCytochrome P450 3A4enzyme
DB00865BenzphetamineCytochrome P450 2B6enzyme
DB00865BenzphetamineNADPH--cytochrome P450 reductaseenzyme
DB00865BenzphetamineSynaptic vesicular amine transportertarget
DB00865BenzphetamineSodium-dependent dopamine transportertarget
DB00867RitodrineBeta-2 adrenergic receptortarget
DB00867Ritodrine6-phosphogluconate dehydrogenase, decarboxylatingenzyme
DB00938SalmeterolBeta-2 adrenergic receptortarget
DB00938SalmeterolCytochrome P450 3A4enzyme
DB00938SalmeterolCytochrome P450 2C8enzyme
DB00938SalmeterolCytochrome P450 3A5enzyme
DB00938SalmeterolCytochrome P450 3A7enzyme
DB00938SalmeterolBeta-1 adrenergic receptortarget
DB00938SalmeterolBeta-3 adrenergic receptortarget
DB01001SalbutamolBeta-2 adrenergic receptortarget
DB01001SalbutamolBeta-1 adrenergic receptortarget
DB01001SalbutamolCytochrome P450 3A4enzyme
DB01001SalbutamolBeta-3 adrenergic receptortarget
DB01037SelegilineAmine oxidase [flavin-containing] Btarget
DB01037SelegilineCytochrome P450 2B6enzyme
DB01037SelegilineAmine oxidase [flavin-containing] Atarget
DB01037SelegilineCytochrome P450 2A6enzyme
DB01037SelegilineCytochrome P450 3A4enzyme
DB01037SelegilineMultidrug resistance protein 1transporter
DB01037SelegilineCytochrome P450 1A2enzyme
DB01037SelegilineCytochrome P450 2C19enzyme
DB01037SelegilineCytochrome P450 2C8enzyme
DB01037SelegilineCytochrome P450 2C9enzyme
DB01037SelegilineCytochrome P450 2D6enzyme
DB01037SelegilineCytochrome P450 2E1enzyme
DB01191DexfenfluramineSodium-dependent serotonin transportertarget
DB01191Dexfenfluramine5-hydroxytryptamine receptor 2Ctarget
DB01191DexfenfluramineCytochrome P450 2D6enzyme
DB01191DexfenfluramineCytochrome P450 1A2enzyme
DB01191DexfenfluramineCytochrome P450 2E1enzyme
DB01255LisdexamfetamineCytochrome P450 2D6enzyme
DB01255LisdexamfetamineSolute carrier family 15 member 1transporter
DB01255LisdexamfetamineTrace amine-associated receptor 1target
DB01364EphedrineAcetylcholinesterasetarget
DB01364EphedrineAlpha-1A adrenergic receptortarget
DB01364EphedrineSodium-dependent noradrenaline transportertarget
DB01364EphedrineSynaptic vesicular amine transportertarget
DB01364EphedrineCholinesteraseenzyme
DB01365MephentermineAlpha adrenergic receptortarget
DB01365MephentermineBeta adrenergic receptortarget
DB01442MMDA5-hydroxytryptamine receptor 2Atarget
DB01442MMDASodium-dependent serotonin transportertarget
DB01442MMDASodium-dependent dopamine transportertarget
DB01442MMDAChromaffin granule amine transportertarget
DB01442MMDASynaptic vesicular amine transportertarget
DB01442MMDAAmine oxidase [flavin-containing] Atarget
DB01442MMDAAmine oxidase [flavin-containing] Btarget
DB01442MMDASodium-dependent noradrenaline transportertarget
DB01454MidomafetamineSodium-dependent serotonin transportertarget
DB01454MidomafetamineSynaptic vesicular amine transportertarget
DB01454MidomafetamineSodium-dependent dopamine transportertarget
DB01454Midomafetamine5-hydroxytryptamine receptor 2Atarget
DB01454Midomafetamine5-hydroxytryptamine receptor 2Btarget
DB01454Midomafetamine5-hydroxytryptamine receptor 2Ctarget
DB01454MidomafetamineSodium-dependent noradrenaline transportertarget
DB01454MidomafetamineSodium-dependent noradrenaline transportertransporter
DB01454MidomafetamineSodium-dependent dopamine transportertransporter
DB01454MidomafetamineSodium-dependent serotonin transportertransporter
DB01454MidomafetamineCytochrome P450 2D6enzyme
DB014724-MethoxyamphetamineAlpha-1A adrenergic receptortarget
DB014724-MethoxyamphetamineAlpha-2A adrenergic receptortarget
DB014724-MethoxyamphetamineCytochrome P450 2D6enzyme
DB014724-MethoxyamphetamineSodium-dependent dopamine transportertarget
DB014724-MethoxyamphetamineSodium-dependent serotonin transportertarget
DB014724-MethoxyamphetamineAmine oxidase [flavin-containing] Atarget
DB014724-MethoxyamphetamineAmine oxidase [flavin-containing] Btarget
DB014724-MethoxyamphetamineSynaptic vesicular amine transportertarget
DB01482FenethyllineCytochrome P450 1A2enzyme
DB015374-Bromo-2,5-dimethoxyphenethylamine5-hydroxytryptamine receptor 2Ctarget
DB015374-Bromo-2,5-dimethoxyphenethylamine5-hydroxytryptamine receptor 2Atarget
DB01576DextroamphetamineAlpha-1A adrenergic receptortarget
DB01576DextroamphetamineAlpha-1B adrenergic receptortarget
DB01576DextroamphetamineSodium-dependent dopamine transportertarget
DB01576DextroamphetamineSodium-dependent noradrenaline transportertarget
DB01576DextroamphetamineSynaptic vesicular amine transportertarget
DB01576DextroamphetamineTrace amine-associated receptor 1target
DB01576DextroamphetamineCytochrome P450 2D6enzyme
DB01576DextroamphetaminePrimary amine oxidaseenzyme
DB01576DextroamphetamineSodium-dependent dopamine transportertransporter
DB01577MetamfetamineCytochrome P450 2D6enzyme
DB01577MetamfetamineSolute carrier family 22 member 3transporter
DB01577MetamfetamineSolute carrier family 22 member 5transporter
DB01577MetamfetamineSodium-dependent dopamine transportertarget
DB01577MetamfetamineSynaptic vesicular amine transportertarget
DB01577MetamfetamineTrace amine-associated receptor 1target
DB01577MetamfetamineSodium-dependent serotonin transportertarget
DB01577MetamfetamineSodium-dependent noradrenaline transportertarget
DB01577MetamfetamineChromaffin granule amine transportertarget
DB01577MetamfetamineAmine oxidase [flavin-containing] Atarget
DB01577MetamfetamineAmine oxidase [flavin-containing] Btarget
DB01577MetamfetamineAlpha-2A adrenergic receptortarget
DB01577MetamfetamineAlpha-2B adrenergic receptortarget
DB01577MetamfetamineAlpha-2C adrenergic receptortarget
DB04825PrenylamineCalmodulintarget
DB04825PrenylamineMyosin light chain kinase 2, skeletal/cardiac muscletarget
DB04825PrenylamineCytochrome P450 3A4enzyme
DB06152NylidrinCatechol O-methyltransferaseenzyme
DB06152NylidrinVoltage-dependent T-type calcium channel subunit alpha-1Itarget
DB06152NylidrinInterferon alpha/beta receptor 2target
DB06152NylidrinCytochrome P450 3A4enzyme
DB08980FendilineCytochrome P450 3A4enzyme
DB11587EtafedrineBeta-2 adrenergic receptortarget
DB12923GallopamilCytochrome P450 3A4enzyme
DB13139LevosalbutamolBeta-2 adrenergic receptortarget
DB13139LevosalbutamolCytochrome P450 3A4enzyme
DB13139LevosalbutamolCytochrome P450 2D6enzyme
DB13139LevosalbutamolSolute carrier organic anion transporter family member 1B1transporter
DB13139LevosalbutamolSolute carrier organic anion transporter family member 1B3transporter
DB139402,5-Dimethoxy-4-ethylthioamphetamine5-hydroxytryptamine receptor 2Atarget
DB139402,5-Dimethoxy-4-ethylthioamphetamine5-hydroxytryptamine receptor 2Ctarget
DB14063DexverapamilMultidrug resistance protein 1target
DB14063DexverapamilCytochrome P450 3A4enzyme
DB14064EmopamilMultidrug resistance protein 1target
DB14064EmopamilCytochrome P450 3A4enzyme