Adrenergic beta-Agonists

Drugs that selectively bind to and activate beta-adrenergic receptors.
DrugDrug NameDrug Indication
DB00668EpinephrineEpinephrine injection is indicated in the emergency treatment of allergic reactions (Type I) including anaphylaxis to stinging insects (e.g., order Hymenoptera, which include bees, wasps, hornets, yellow jackets and fire ants) and biting insects (e.g., triatoma, mosquitos), allergen immunotherapy, foods, drugs, diagnostic testing substances (e.g., radiocontrast media) and other allergens, as well as idiopathic anaphylaxis or exercise-induced anaphylaxis. Injectable epinephrine is intended for immediate/urgent administration in patients, who are found to be at increased risk for anaphylaxis, including individuals with a history of anaphylaxis. Selection of the appropriate dosage strength is determined according to body weight [FDA label]. Epinephrine's cardiac effects may be of use in restoring cardiac rhythm in cardiac arrest due to various causes but is not used in cardiac failure or in hemorrhagic, traumatic, or cardiogenic shock [F1247]. Epinephrine is used as a hemostatic agent. It is also used in treating mucosal congestion of hay fever, rhinitis, and acute sinusitis; to relieve bronchial asthmatic paroxysms; in syncope due to complete heart block or carotid sinus hypersensitivity; for symptomatic relief of serum sickness, urticaria, angioneurotic edema; for resuscitation in cardiac arrest following anesthetic accidents; in simple (open angle) glaucoma; for relaxation of uterine musculature and to inhibit uterine contractions. Epinephrine injection can be utilized to prolong the action of local anesthetics [F1247]. In addition to the above, epinephrine is used as an over the counter (OTC) agent for the intermittent symptoms of asthma, such as wheezing, tightness of chest and shortness of breath [F2131]. It is also used for the maintenance of mydriasis during intraocular surgery [L4825].
DB00841DobutamineIndicated when parenteral therapy is necessary for inotropic support in the short-term treatment of patients with cardiac decompensation due to depressed contractility resulting either from organic heart disease or from cardiac surgical procedures.
DB01064IsoprenalineFor the treatment of mild or transient episodes of heart block that do not require electric shock or pacemaker therapy also used in management of asthma and chronic bronchitis
DB00221IsoetarineFor the treatment of asthma, wheezing, and chronic asthmatic bronchitis.
DB00816OrciprenalineFor the treatment of bronchospasm, chronic bronchitis, asthma, and emphysema.
DB00867RitodrineFor the treatment and prophylaxis of premature labour
DB00871TerbutalineFor the prevention and reversal of bronchospasm in patients 12 years of age and older with reversible, obstructive airway disease, as well as symptomatic management of reversible bronchospasm associated with bronchitis and emphysema. Also used acute IV and sub-Q therapy in selected women to inhibit uterine contractions in preterm labor (tocolysis) and prolong gestation when beneficial.
DB00901BitolterolUsed to dilate air passages in the lungs that have become narrowed as a result of disease or inflammation. It is used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).
DB00938SalmeterolFor the treatment of asthma and chronic obstructive pulmonary disease (COPD).
DB00983FormoterolFor use as long-term maintenance treatment of asthma in patients 6 years of age and older with reversible obstructive airways disease, including patients with symptoms of nocturnal asthma, who are using optimal corticosteroid treatment and experiencing regular or frequent breakthrough symptoms requiring use of a short-acting bronchodilator. Not indicated for asthma that can be successfully managed with occasional use of an inhaled, short-acting beta2-adrenergic agonist. Also used for the prevention of exercise-induced bronchospasm, as well as long-term treatment of bronchospasm associated with COPD.
DB01001SalbutamolSalbutamol is indicated for (i) the symptomatic relief and prevention of bronchospasm due to bronchial asthma, chronic bronchitis, reversible obstructive airway disease, and other chronic bronchopulmonary disorders in which bronchospasm is a complicating factor, and/or (ii) the acute prophylaxis against exercise-induced bronchospasm and other stimuli known to induce bronchospasm [FDA Label, F3265, F3268].
DB01102ArbutamineUsed to elicit acute cardiovascular responses (cardiac stumulant), similar to those produced by exercise, in order to aid in diagnosing the presence or absence of coronary artery disease (CAD) in patients who cannot exercise adequately.
DB01274ArformoterolA bronchodilator used for the long term, symptomatic treatment of reversible bronchoconstriction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema.
DB01288FenoterolFenoterol is used for the treatment of asthma.
DB01291PirbuterolFor the prevention and reversal of bronchospasm in patients 12 years of age and older with reversible bronchospasm including asthma.
DB01366ProcaterolFor the treatment of asthma and chronic obstructive pulmonary disease (COPD).
DB01407ClenbuterolUsed as a bronchodilator in the treatment of asthma patients.
DB04861NebivololFor the treatment of essential hypertension.
DB05395AmibegronInvestigated for use/treatment in depression, irritable bowel syndrome (IBS), and obesity.
DB06152NylidrinNylidrin is mainly indicated in conditions like arteriosclerosis, cerebrovascular disease, peripheral vascular disease, Raynaud's disease, thrombo-angitis obliterans, and thrombophlebitis [L2285]. It may sometimes be used in the treatment of peripheral vascular disorders in addition premature labor (however, the drug is not approved for premature labor)[A32531].
DB06190SolabegronInvestigated for use/treatment in diabetes mellitus type 2, irritable bowel syndrome (IBS), and urinary incontinence.
DB08893MirabegronMirabegron is a beta-3 adrenergic agonist indicated for the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and urinary frequency.
DB08941IsoxsuprineNot Available
DB08957HexoprenalineNot Available
DB08985EtilefrineNot Available
DB09013BefunololUsed in the management of open angle glaucoma. PMID: 12480285.
DB09080OlodaterolOlodaterol is indicated for use in chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema. It is not indicated for the treatment of acute exacerbations of COPD or for the treatment of asthma.
DB11124RacepinephrineIndicated for temporary relief of mild symptoms of intermittent asthma.
DB11541RactopamineNot Available
DB12080RitobegronNot Available
DB12248TulobuterolNot Available
DB12313DopexamineNot Available
DB12779HigenamineNot Available
DB12846ReproterolNot Available
DB13398OxyfedrineNot Available
DB13559RimiterolNot Available
DB13624MethoxyphenamineNot Available
DB13692TretoquinolNot Available
DB13777PrenalterolNot Available
DB13781XamoterolNot Available
DB01364EphedrineEphedrine commonly used as a stimulant, appetite suppressant, concentration aid, decongestant, and to treat hypotension associated with anaesthesia.
DB12100AbediterolNot Available
DB05039IndacaterolFor the long term, once-daily-dosing maintenance of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema.
DB13139LevosalbutamolIndicated for the management of COPD (chronic obstructive pulmonary disease, also known as chronic obstructive lung disease) and asthma.
DB00368NorepinephrineMainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.
DB01408BambuterolFor the prevention and reversal of bronchospasm in patients 12 years of age and older with asthma and reversible bronchospasm associated with bronchitis and emphysema.
DB06262DroxidopaFor treatment of neurogenic orthostatic hypotension (NOH) associated with various disorders including Multiple System Atrophy, Familial Amyloid Polyneuropathy, hemodialysis induced hypotension and Parkinson's Disease. Also investigated for use/treatment in neurologic disorders, nephropathy, blood (blood forming organ disorders, unspecified), and dizzy/fainting spells.
DB00449DipivefrinDipivefrin is a prodrug which is used as initial therapy for the control of intraocular pressure in chronic open-angle glaucoma.
DB01363Ephedra sinica rootEphedra is widely used by athletes, despite a lack of evidence that it enhances athletic performance. Ephedra has also been used for weight loss.
DB00397PhenylpropanolamineFor the treatment of nasal congestion, control of urinary incontinence, priapism and obesity.
DB09082VilanterolVilanterol is approved for use in several combination products such as with fluticasone furoate under the tradename Breo Ellipta and in combination with umeclidinium bromide as Anoro Ellipta. Approved by the FDA in 2013, use of Breo Ellipta is indicated for the long-term, once-daily maintenance treatment of airflow obstruction in patients with COPD, including chronic bronchitis and emphysema. It is also indicated for once-daily maintenance treatment of asthma in patients aged 18 or older with reversible obstructive airways disease.
DB04846CeliprololCeliprolol is indicated for the management of mild to moderate hypertension and effort-induced angina pectoris.
DB09273DoxofyllineIndicated for the treatment of chronic obstructive pulmonary disease (COPD), bronchial asthma and pulmonary disease with spastic bronchial component.
DB06814ProtokylolNot Available
DB11587EtafedrineConditions characterized by bronchial congestion and bronchospasm when an expectorant or bronchodilator action is required, such as acute bronchitis, acute episodes of chronic bronchitis and bronchial asthma [L2565], [L2566].
DB11871PF-00610355Not Available
DB00852PseudoephedrineFor the treatment of nasal congestion, sinus congestion, Eustachian tube congestion, and vasomotor rhinitis, and as an adjunct to other agents in the optimum treatment of allergic rhinitis, croup, sinusitis, otitis media, and tracheobronchitis. Also used as first-line therapy of priapism.
DrugDrug NameTargetType
DB00668EpinephrineAlpha-1A adrenergic receptortarget
DB00668EpinephrineBeta-1 adrenergic receptortarget
DB00668EpinephrineBeta-2 adrenergic receptortarget
DB00668EpinephrineSolute carrier family 22 member 2transporter
DB00668EpinephrineSolute carrier family 22 member 1transporter
DB00668EpinephrineCytochrome P450 2C9enzyme
DB00668EpinephrineCytochrome P450 3A4enzyme
DB00668EpinephrineAlpha-1B adrenergic receptortarget
DB00668EpinephrineAlpha-1D adrenergic receptortarget
DB00668EpinephrineAlpha-2A adrenergic receptortarget
DB00668EpinephrineAlpha-2B adrenergic receptortarget
DB00668EpinephrineTumor necrosis factortarget
DB00668EpinephrineCatechol O-methyltransferaseenzyme
DB00668EpinephrineMonoamine oxidaseenzyme
DB00841DobutamineBeta-1 adrenergic receptortarget
DB00841DobutamineCatechol O-methyltransferaseenzyme
DB00841DobutamineBeta-2 adrenergic receptortarget
DB00841DobutamineAlpha-1 adrenergic receptorstarget
DB00841DobutamineEstrogen receptor alphatarget
DB01064IsoprenalineBeta-1 adrenergic receptortarget
DB01064IsoprenalineBeta-2 adrenergic receptortarget
DB01064IsoprenalinePhosphatidylinositol 3-kinase regulatory subunit alphatarget
DB01064IsoprenalineBeta-3 adrenergic receptortarget
DB01064IsoprenalineMitogen-activated protein kinase 1target
DB01064IsoprenalinePhosphatidylinositol 3-kinase regulatory subunit betatarget
DB01064IsoprenalinePhosphatidylinositol 3-kinase regulatory subunit gammatarget
DB01064IsoprenalineCytochrome P450 1A1enzyme
DB01064IsoprenalineCAMP phosphodiesterasetarget
DB01064IsoprenalineSuperoxide dismutase [Cu-Zn]target
DB00221IsoetarineBeta-1 adrenergic receptortarget
DB00221IsoetarineBeta-2 adrenergic receptortarget
DB00816OrciprenalineBeta-2 adrenergic receptortarget
DB00867RitodrineBeta-2 adrenergic receptortarget
DB00867Ritodrine6-phosphogluconate dehydrogenase, decarboxylatingenzyme
DB00871TerbutalineBeta-2 adrenergic receptortarget
DB00871TerbutalineCholinesteraseenzyme
DB00871TerbutalineBeta-3 adrenergic receptortarget
DB00871TerbutalineBeta-1 adrenergic receptortarget
DB00901BitolterolBeta-2 adrenergic receptortarget
DB00938SalmeterolBeta-2 adrenergic receptortarget
DB00938SalmeterolCytochrome P450 3A4enzyme
DB00938SalmeterolCytochrome P450 2C8enzyme
DB00938SalmeterolCytochrome P450 3A5enzyme
DB00938SalmeterolCytochrome P450 3A7enzyme
DB00938SalmeterolBeta-1 adrenergic receptortarget
DB00938SalmeterolBeta-3 adrenergic receptortarget
DB00983FormoterolBeta-2 adrenergic receptortarget
DB00983FormoterolCytochrome P450 2C19enzyme
DB00983FormoterolCytochrome P450 2C9enzyme
DB00983FormoterolCytochrome P450 2D6enzyme
DB00983FormoterolCytochrome P450 2A6enzyme
DB00983FormoterolBeta-1 adrenergic receptortarget
DB00983FormoterolBeta-3 adrenergic receptortarget
DB01001SalbutamolBeta-2 adrenergic receptortarget
DB01001SalbutamolBeta-1 adrenergic receptortarget
DB01001SalbutamolCytochrome P450 3A4enzyme
DB01001SalbutamolBeta-3 adrenergic receptortarget
DB01102ArbutamineBeta-1 adrenergic receptortarget
DB01102ArbutamineBeta-2 adrenergic receptortarget
DB01102ArbutamineBeta-3 adrenergic receptortarget
DB01274ArformoterolBeta-2 adrenergic receptortarget
DB01274ArformoterolCytochrome P450 2D6enzyme
DB01274ArformoterolCytochrome P450 2C19enzyme
DB01274ArformoterolCytochrome P450 2A6enzyme
DB01274ArformoterolCytochrome P450 2C9enzyme
DB01288FenoterolBeta-2 adrenergic receptortarget
DB01288FenoterolBeta-1 adrenergic receptortarget
DB01288FenoterolBeta-3 adrenergic receptortarget
DB01291PirbuterolBeta-2 adrenergic receptortarget
DB01291PirbuterolBeta-1 adrenergic receptortarget
DB01366ProcaterolBeta-2 adrenergic receptortarget
DB01407ClenbuterolBeta-2 adrenergic receptortarget
DB01407ClenbuterolBeta-nerve growth factortarget
DB01407ClenbuterolTumor necrosis factortarget
DB01407ClenbuterolBeta-1 adrenergic receptortarget
DB01407ClenbuterolBeta-3 adrenergic receptortarget
DB01407ClenbuterolCytochrome P450 1A1enzyme
DB04861NebivololBeta-1 adrenergic receptortarget
DB04861NebivololCytochrome P450 2D6enzyme
DB04861NebivololBeta-2 adrenergic receptortarget
DB04861NebivololCytochrome P450 3A4enzyme
DB05395AmibegronBeta-3 adrenergic receptortarget
DB06152NylidrinCatechol O-methyltransferaseenzyme
DB06152NylidrinVoltage-dependent T-type calcium channel subunit alpha-1Itarget
DB06152NylidrinInterferon alpha/beta receptor 2target
DB06152NylidrinCytochrome P450 3A4enzyme
DB06190SolabegronBeta-3 adrenergic receptortarget
DB08893MirabegronCytochrome P450 3A4enzyme
DB08893MirabegronCytochrome P450 2D6enzyme
DB08893MirabegronMultidrug resistance protein 1transporter
DB08893MirabegronSolute carrier organic anion transporter family member 1A2transporter
DB08893MirabegronSerum albumincarrier
DB08893MirabegronAlpha-1-acid glycoprotein 1carrier
DB08893MirabegronCholinesteraseenzyme
DB08893MirabegronBeta-3 adrenergic receptortarget
DB09013BefunololBeta-1 adrenergic receptortarget
DB09013BefunololBeta-2 adrenergic receptortarget
DB09013BefunololCytochrome P450 2D6enzyme
DB09080OlodaterolBeta-2 adrenergic receptortarget
DB09080OlodaterolCytochrome P450 2C9enzyme
DB09080OlodaterolCytochrome P450 2C8enzyme
DB11124RacepinephrineAlpha-1A adrenergic receptortarget
DB11124RacepinephrineAlpha-1B adrenergic receptortarget
DB11124RacepinephrineAlpha-2A adrenergic receptortarget
DB11124RacepinephrineAlpha-2B adrenergic receptortarget
DB11124RacepinephrineAlpha-2C adrenergic receptortarget
DB11124RacepinephrineBeta-1 adrenergic receptortarget
DB11124RacepinephrineBeta-2 adrenergic receptortarget
DB11124RacepinephrineAlpha-1D adrenergic receptortarget
DB11124RacepinephrineBeta-3 adrenergic receptortarget
DB11541RactopamineEstrogen receptor alphatarget
DB12248TulobuterolBeta-2 adrenergic receptortarget
DB13781XamoterolBeta-1 adrenergic receptortarget
DB01364EphedrineAcetylcholinesterasetarget
DB01364EphedrineAlpha-1A adrenergic receptortarget
DB01364EphedrineSodium-dependent noradrenaline transportertarget
DB01364EphedrineSynaptic vesicular amine transportertarget
DB01364EphedrineCholinesteraseenzyme
DB05039IndacaterolBeta-2 adrenergic receptortarget
DB05039IndacaterolCytochrome P450 3A4enzyme
DB05039IndacaterolUDP-glucuronosyltransferase 1-1enzyme
DB05039IndacaterolMultidrug resistance protein 1transporter
DB13139LevosalbutamolBeta-2 adrenergic receptortarget
DB13139LevosalbutamolCytochrome P450 3A4enzyme
DB13139LevosalbutamolCytochrome P450 2D6enzyme
DB13139LevosalbutamolSolute carrier organic anion transporter family member 1B1transporter
DB13139LevosalbutamolSolute carrier organic anion transporter family member 1B3transporter
DB00368NorepinephrinePhenylalanine-4-hydroxylasetarget
DB00368NorepinephrineAlpha-1A adrenergic receptortarget
DB00368NorepinephrineAlpha-1B adrenergic receptortarget
DB00368NorepinephrineAlpha-1D adrenergic receptortarget
DB00368NorepinephrineAlpha-2A adrenergic receptortarget
DB00368NorepinephrineAlpha-2B adrenergic receptortarget
DB00368NorepinephrineAlpha-2C adrenergic receptortarget
DB00368NorepinephrineBeta-1 adrenergic receptortarget
DB00368NorepinephrineBeta-2 adrenergic receptortarget
DB00368NorepinephrineBeta-3 adrenergic receptortarget
DB00368NorepinephrineSolute carrier family 22 member 2transporter
DB00368NorepinephrineSolute carrier family 22 member 3transporter
DB00368NorepinephrineSolute carrier family 22 member 5transporter
DB00368NorepinephrineSolute carrier family 22 member 1transporter
DB00368NorepinephrinePOU domain, class 5, transcription factor 1transporter
DB00368NorepinephrineSodium-dependent noradrenaline transportertransporter
DB00368NorepinephrineSynaptic vesicular amine transportertarget
DB00368NorepinephrineChromaffin granule amine transportertarget
DB01408BambuterolBeta-2 adrenergic receptortarget
DB01408BambuterolCholinesteraseenzyme
DB06262DroxidopaPhenylalanine-4-hydroxylasetarget
DB06262DroxidopaAlpha-1A adrenergic receptortarget
DB06262DroxidopaAlpha-1B adrenergic receptortarget
DB06262DroxidopaAlpha-1D adrenergic receptortarget
DB06262DroxidopaAlpha-2A adrenergic receptortarget
DB06262DroxidopaAlpha-2B adrenergic receptortarget
DB06262DroxidopaAlpha-2C adrenergic receptortarget
DB06262DroxidopaBeta-1 adrenergic receptortarget
DB06262DroxidopaBeta-2 adrenergic receptortarget
DB06262DroxidopaBeta-3 adrenergic receptortarget
DB06262DroxidopaAromatic-L-amino-acid decarboxylaseenzyme
DB06262DroxidopaMonocarboxylate transporter 10transporter
DB06262DroxidopaSodium-dependent noradrenaline transportertransporter
DB00449DipivefrinAlpha-2A adrenergic receptortarget
DB00449DipivefrinCholinesterasetarget
DB00449DipivefrinBeta-2 adrenergic receptortarget
DB00449DipivefrinAlpha-1A adrenergic receptortarget
DB00449DipivefrinAcetylcholinesterasetarget
DB01363Ephedra sinica rootSodium-dependent dopamine transportertarget
DB01363Ephedra sinica rootSynaptic vesicular amine transportertarget
DB01363Ephedra sinica rootChromaffin granule amine transportertarget
DB01363Ephedra sinica rootSodium-dependent noradrenaline transportertarget
DB01363Ephedra sinica rootAmine oxidase [flavin-containing] Atarget
DB01363Ephedra sinica rootAmine oxidase [flavin-containing] Btarget
DB01363Ephedra sinica rootSodium-dependent serotonin transportertarget
DB01363Ephedra sinica rootAlpha-2A adrenergic receptortarget
DB01363Ephedra sinica rootAlpha-2B adrenergic receptortarget
DB01363Ephedra sinica rootAlpha-2C adrenergic receptortarget
DB01363Ephedra sinica rootBeta-1 adrenergic receptortarget
DB01363Ephedra sinica rootBeta-2 adrenergic receptortarget
DB01363Ephedra sinica rootBeta-3 adrenergic receptortarget
DB00397PhenylpropanolamineAmine oxidase [flavin-containing] Aenzyme
DB00397PhenylpropanolamineD(1A) dopamine receptortarget
DB00397PhenylpropanolamineBeta-1 adrenergic receptortarget
DB00397PhenylpropanolamineBeta-2 adrenergic receptortarget
DB00397PhenylpropanolamineAlpha-2 adrenergic receptorstarget
DB09082VilanterolCytochrome P450 3A4enzyme
DB09082VilanterolBeta-2 adrenergic receptortarget
DB04846CeliprololBeta-1 adrenergic receptortarget
DB04846CeliprololBeta-2 adrenergic receptortarget
DB04846CeliprololBeta-3 adrenergic receptortarget
DB04846CeliprololAlpha-2A adrenergic receptortarget
DB04846CeliprololAlpha-2B adrenergic receptortarget
DB04846CeliprololAlpha-2C adrenergic receptortarget
DB04846CeliprololCytochrome P450 2D6enzyme
DB09273DoxofyllinePhosphodiesterase 2A, cGMP-stimulatedtarget
DB09273DoxofyllineAdenosine receptor A2atarget
DB09273DoxofyllineBeta-2 adrenergic receptortarget
DB09273DoxofyllineCytochrome P450 1A2enzyme
DB06814ProtokylolBeta-2 adrenergic receptortarget
DB11587EtafedrineBeta-2 adrenergic receptortarget
DB00852PseudoephedrineAlpha-1A adrenergic receptortarget
DB00852PseudoephedrineAlpha-2A adrenergic receptortarget
DB00852PseudoephedrineBeta-2 adrenergic receptortarget
DB00852PseudoephedrineAmine oxidase [flavin-containing] Aenzyme
DB00852PseudoephedrineBeta-1 adrenergic receptortarget
DB00852PseudoephedrineCytochrome P450 2D6enzyme
DB00852PseudoephedrineSodium-dependent dopamine transportertarget
DB00852PseudoephedrineSodium-dependent noradrenaline transportertarget
DB00852PseudoephedrineSodium-dependent serotonin transportertarget
DB00852PseudoephedrineNuclear factor of activated T-cells, cytoplasmic 1target
DB00852PseudoephedrineTumor necrosis factortarget
DB00852PseudoephedrineNuclear factor kappa-light-chain-enhancer of activated B cellstarget
DB00852Pseudoephedrineactivator protein 1target
DB00852PseudoephedrineInterleukin-2target