Agents that produce neuromuscular block (indirect)

Name
Agents that produce neuromuscular block (indirect)
Accession Number
DBCAT003930
Description

In this category, it is included all agents that induce neuromuscular block as a secondary effect or side effect.

Drugs
DrugDrug Description
CapreomycinAn aminoglycoside antibiotic used as an adjunct drug in tuberculosis.
ColistimethateAn antibiotic indicated for treatment of infections caused by susceptible strains of certain gram-negative bacilli. It is particularly useful for targeting sensitive strains of Pseudomonas aeruginosa.
ColistinA polymyxin antibiotic used to treat bacterial infections caused by susceptible Gram negative bacteria.
StreptomycinAn aminoglycoside antibiotic indicated to treat mycobacterium tuberculosis and various non-tuberculosis infections.
KanamycinAn aminoglycoside antibiotic agent used in the treatment of various infections caused by susceptible bacteria.
MinocyclineA tetracycline analog used to treat a wide variety of infections in the body.
DoxycyclineA tetracycline antibiotic used to treat a wide variety of bacterial infections.
LymecyclineA tetracycline antibiotic used for the treatment of acne vulgaris and other susceptible infections.
MetacyclineFor the treatment of acute bacterial exacerbations of chronic bronchitis
RolitetracyclineA broad-spectrum tetracycline antibiotic used in cases needing high concentrations or when oral administration is impractical.
ClomocyclineFor the treatment and management of Brucellosis, mycoplasma infection, acne vulgaris, chlamydial infection;Chronic bronchitis
TigecyclineA glycylcycline antibiotic used to treat a number of susceptible bacterial infections.
TetracyclineAn antibiotic used to treat a wide variety of susceptible infections.
OxytetracyclineA tetracycline antibiotic used to treat a wide variety of susceptible bacterial infections.
DemeclocyclineA tetracycline antibiotic used to treat a wide variety of susceptible bacterial infections.
ChlortetracyclineThe first tetracycline antibiotic most commonly used for veterinary purposes.
PenimepicyclinePenimepicycline is a tetracycline-class antibiotic. It is mentioned on List A produced by the Government of Canada, which is a list of antimicrobial active pharmaceutical ingredients . In the classification...
ProcainamideA medication used to treat life threatening ventricular arrhythmias.
QuinidineA medication used to restore normal sinus rhythm, treat atrial fibrillation and flutter, and treat ventricular arrhythmias.
QuinineAn alkaloid used to treat uncomplicated Plasmodium falciparum malaria.
ChloroquineAn antimalarial drug used to treat susceptible infections with P. vivax, P. malariae, P. ovale, and P. falciparum. It is also used for second line treatment for rheumatoid arthritis.
Etacrynic acidA diuretic used to treat ascites and edema in congestive heart failure, liver cirrhosis, and renal disease.
VancomycinA glycopeptide antibiotic used to treat severe but susceptible bacterial infections such as MRSA (methicillin-resistant Staphylococcus aureus) infections.
TobramycinAn aminoglycoside antibiotic used to treat cystic fibrosis, lung infections, eye infections, and a variety of other infections.
GentamicinAn aminoglycoside used to treat a wide variety of infections in the body.
NeomycinAn aminoglycoside antibiotic agent used orally and topically to treat a wide variety of infections in the body.
FramycetinAn aminoglycoside antibiotic used in various formulations and combinations with other agents to treat hemorrhoids, eye and ear infections, and to reduce nasal carriage of staphylococcus.
NetilmicinAn aminoglycoside used to treat a wide variety of infections in the body.
ParomomycinAn aminoglycoside antibiotic used in the treatment of acute and chronic intestinal amebiasis, and as an adjunct for the management of hepatic coma.
RibostamycinA broad spectrum aminoglycoside antibiotic on the list of WHO critical antimicrobials for human medicine.
GeneticinGeneticin (also known as G418) is an aminoglycoside antibiotic similar in structure to gentamicin B1, produced by Micromonospora rhodorangea. Geneticin blocks polypeptide synthesis by inhibiting the elongation step in both...
ApramycinFor the treatment of bacterial infections in animals.
NeamineNot Available
ArbekacinArbekacin is used for the short term treatment of multi-resistant bacterial infections, such as methicillin-resistant Staphylococcus aureus (MRSA).
PuromycinPuromycin is an antibiotic that prevents bacterial protein translation. It is utilized as a selective agent in laboratory cell cultures. Puromycin is toxic to both prokaryotic and eukaryotic cells, resulting...
DihydrostreptomycinDihydrostreptomycin is an antibiotic.
Hygromycin BHygromycin B is an aminoglycoside antibiotic produced by the bacterium Streptomyces hygroscopicus which kills bacteria, fungi and higher eukaryotic cells by inhibiting protein synthesis.
SisomicinSisomicin has been used in trials studying the treatment of Pyoderma.
PlazomicinAn aminoglycoside antibiotic used to treat complicated urinary tract infections.
DibekacinDibekacin is an aminoglycoside antibiotic marketed in Japan .
MicronomicinMicronomicin is an aminoglycoside antibiotic which is marketed in Japan, and sold under the brand names Sagamicin and Luxomicina.
IsepamicinNot Annotated
BekanamycinNot Annotated
Botulinum toxin type AA purified form of botulinum toxin type A used to block acetylcholine release in the treatment of chronic sialorrhea, muscle spasticity, and dystonia, as well as in cosmetic applications.
Botulinum Toxin Type BA purified form of botulinum toxin type B used to block acetylcholine release in the treatment of cervical dystonia and sialorrhea.
ClindamycinA lincosamide antibiotic used to treat serious infections caused by susceptible anaerobic, streptococcal, staphylococcal, and pneumococcal bacteria.
CyclosporineA steroid-sparing immunosuppressant used in organ and bone marrow transplants as well as inflammatory conditions such as ulcerative colitis, rheumatoid arthritis, and atopic dermatitis.
LincomycinAn antibiotic indicated only for the treatment of serious infections, and is typically reserved for use in cases of penicillin allergy or where penicillin is inappropriate.
Magnesium silicateMagnesium silicate is used to absorb moisture, prevent caking, and to improve the feel of a product. In the pharmaceutical companies, it is used as a dietary supplement, as part...
Magnesium glycinateMagnesium glycinate is a magnesium salt of glycine that is available as dietary supplements as a source of magnesium. It is used in the treatment of magnesium deficiency.
Magnesium trisilicateAn antacid used for the symptomatic treatment of peptic ulcers.
Magnesium orotateMagnesium orotate is a magnesium salt of orotic acid and is poorly soluble in water. It is a source of magnesium and is used as a mineral supplement to treat...
Magnesium aspartateMagnesium aspartate is a magnesium salt of aspartic acid that is commonly used as a mineral supplement. It displays high oral bioavailability and water solubiltiy compared to other magnesium salts...
Magnesium Aluminum SilicateMagnesium aluminum silicate is used as an over the counter antacid for the self-treatment of heartburn, sour stomach, or acid indigestion [FDA Label].
Magnesium chlorideAn ionic compound and source of magnesium used for electrolyte replenishment and conditions associated with magnesium deficiencies.
Magnesium gluconateA mineral supplement used to treat or prevent hypomagnesemia.
Magnesium stearateNot Annotated
Magnesium acetateNot Available
Magnesium sulfateA drug used to treat convulsions during pregnancy, nephritis in children, magnesium deficiency, and tetany.
Magnesium acetate tetrahydrateAn ionic compound used for electrolyte replenishment and total parenteral nutrition (TPN) therapy.
Magnesium citrateA laxative used in bowel preparation for colonoscopy or as a magnesium supplement.
Magnesium oxideA compound commonly used as a laxative for the symptomatic relief of acid indigestion and upset stomach, and in health supplements for cardiovascular and neuromuscular health.
Magnesium carbonateAn antacid used for symptomatic relief of heartburn, indigestion, and upset stomach.
Magnesium phosphateNot Annotated
Magnesium cationMagnesium hydroxide is used primarily in "Milk of Magnesia", a white aqueous, mildly alkaline suspension of magnesium hydroxide formulated at about 8%w/v. Milk of magnesia is primarily used to alleviate...
Magnesium hydroxideAn inorganic compound used as a laxative and antacid.
Gentamicin C1aNot Available
ViomycinViomycin is an essential component in the drug cocktail currently used to fight infections of Mycobacterium tuberculosis.
MecamylamineA nicotine antagonist used to treat moderate to severe essential hypertension and uncomplicated malignant hypertension.
PiperacillinA penicillin antibiotic combined with tazobactam to treat piperacillin-resistant, piperacillin/tazobactam­ susceptible, β-lactamase generating strains of several bacteria.
DantroleneA direct-acting skeletal muscle relaxant used for the treatment of management of the fulminant hypermetabolism of skeletal muscle leading to malignant hyperthermia crisis.
Drugs & Drug Targets
DrugTargetType
Capreomycin16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyAtarget
ColistimethateBacterial outer membranetarget
ColistinBacterial outer membranetarget
Streptomycin30S ribosomal protein S12target
Streptomycin16S ribosomal RNAtarget
StreptomycinSolute carrier family 22 member 6transporter
StreptomycinProtein-arginine deiminase type-4target
Kanamycin30S ribosomal protein S12target
Kanamycin16S ribosomal RNAtarget
KanamycinAminoglycoside 2'-N-acetyltransferaseenzyme
KanamycinKanamycin nucleotidyltransferaseenzyme
KanamycinAminoglycoside 3'-phosphotransferaseenzyme
Minocycline30S ribosomal protein S4target
Minocycline30S ribosomal protein S9target
Minocycline16S ribosomal RNAtarget
MinocyclineInterleukin-1 betatarget
MinocyclineArachidonate 5-lipoxygenasetarget
MinocyclineMatrix metalloproteinase-9target
MinocyclineVascular endothelial growth factor Atarget
MinocyclineCaspase-1target
MinocyclineCaspase-3target
MinocyclineCytochrome ctarget
MinocyclineSolute carrier family 22 member 6transporter
MinocyclineSolute carrier family 22 member 7transporter
MinocyclineOuter membrane protein Ftransporter
MinocyclineOuter membrane porin Ctransporter
MinocyclineMitogen-activated Protein Kinasestarget
MinocyclineNitric oxide synthase, inducibletarget
Doxycycline16S ribosomal RNAtarget
DoxycyclineSolute carrier family 22 member 6transporter
DoxycyclineCytochrome P450 3A4enzyme
DoxycyclineATP-binding cassette sub-family B member 5transporter
Lymecycline30S ribosomal protein S4target
MetacyclineSerum albumincarrier
Metacycline16S ribosomal RNAtarget
Rolitetracycline30S ribosomal protein S9target
Rolitetracycline16S ribosomal RNAtarget
Clomocycline30S ribosomal protein S4target
Clomocycline30S ribosomal protein S9target
Clomocycline16S ribosomal RNAtarget
Tigecycline30S ribosomal protein S9target
Tigecycline16S ribosomal RNAtarget
Tigecycline30S ribosomal protein S14target
Tigecycline30S ribosomal protein S13target
Tigecycline30S ribosomal protein S19target
Tigecycline30S ribosomal protein S12target
Tetracycline16S ribosomal RNAtarget
TetracyclineMajor prion proteintarget
TetracyclineSerum albumincarrier
TetracyclineCytochrome P450 3A4enzyme
TetracyclineSolute carrier family 22 member 6transporter
TetracyclineSolute carrier family 22 member 8transporter
TetracyclineSolute carrier family 22 member 11transporter
TetracyclineSolute carrier family 22 member 7transporter
Tetracycline30S ribosomal protein S3target
Tetracycline30S ribosomal protein S8target
Tetracycline30S ribosomal protein S19target
Tetracycline30S ribosomal protein S14target
Tetracycline30S ribosomal protein S7target
TetracyclineMultidrug translocase MdfAtarget
TetracyclineProtein-arginine deiminase type-4target
TetracyclineSolute carrier organic anion transporter family member 2B1transporter
Oxytetracycline30S ribosomal protein S4target
Oxytetracycline30S ribosomal protein S9target
Oxytetracycline16S ribosomal RNAtarget
OxytetracyclineSolute carrier family 22 member 6transporter
OxytetracyclineSolute carrier family 22 member 8transporter
OxytetracyclineSolute carrier family 22 member 11transporter
OxytetracyclineSolute carrier family 22 member 7transporter
OxytetracyclineSerum albumincarrier
Demeclocycline30S ribosomal protein S4target
Demeclocycline30S ribosomal protein S9target
Chlortetracycline16S ribosomal RNAtarget
ChlortetracyclineSerum albumincarrier
Chlortetracycline30S ribosomal protein S3target
Chlortetracycline30S ribosomal protein S8target
Chlortetracycline30S ribosomal protein S19target
Chlortetracycline30S ribosomal protein S14target
Chlortetracycline30S ribosomal protein S7target
ProcainamideSodium channel protein type 5 subunit alphatarget
ProcainamideDNA (cytosine-5)-methyltransferase 1target
ProcainamideCytochrome P450 2D6enzyme
ProcainamideCholinesteraseenzyme
ProcainamideSolute carrier family 22 member 2transporter
ProcainamideSolute carrier family 22 member 1transporter
ProcainamideSolute carrier family 22 member 3transporter
ProcainamideSolute carrier family 22 member 5transporter
ProcainamideSolute carrier family 22 member 4transporter
ProcainamidePotassium voltage-gated channel subfamily H member 2target
ProcainamideMultidrug and toxin extrusion protein 1transporter
ProcainamideMultidrug and toxin extrusion protein 2transporter
QuinidineSodium channel protein type 5 subunit alphatarget
QuinidineAlpha-1-acid glycoprotein 1carrier
QuinidinePotassium voltage-gated channel subfamily H member 2target
QuinidinePotassium channel subfamily K member 1target
QuinidinePotassium channel subfamily K member 6target
QuinidineCytochrome P450 1A2enzyme
QuinidineCytochrome P450 2E1enzyme
QuinidineCytochrome P450 1A1enzyme
QuinidineCytochrome P450 2D6enzyme
QuinidineCytochrome P450 3A4enzyme
QuinidineCytochrome P450 3A7enzyme
QuinidineSolute carrier family 22 member 2transporter
QuinidineSolute carrier family 22 member 1transporter
QuinidineSolute carrier family 22 member 5transporter
QuinidineP-glycoprotein 1transporter
QuinidineSolute carrier organic anion transporter family member 1A2transporter
QuinidineSolute carrier family 22 member 8transporter
QuinidineCanalicular multispecific organic anion transporter 1transporter
QuinidineSolute carrier family 22 member 4transporter
QuinidineSolute carrier organic anion transporter family member 1B1transporter
QuinidineCytochrome P450 2B6enzyme
QuinidineCytochrome P450 2C9enzyme
QuinidineAlpha-1A adrenergic receptortarget
QuinidineAlpha-1B adrenergic receptortarget
QuinidineAlpha-1D adrenergic receptortarget
QuinidineBile salt export pumptransporter
QuinidineCytochrome P450 2C8enzyme
QuininePlatelet glycoprotein IXtarget
QuinineIntermediate conductance calcium-activated potassium channel protein 4target
QuinineCytochrome P450 3A4enzyme
QuinineCytochrome P450 3A5enzyme
QuinineCytochrome P450 1A1enzyme
QuinineCytochrome P450 2D6enzyme
QuinineCytochrome P450 1A2enzyme
QuinineCytochrome P450 2C8enzyme
QuinineCytochrome P450 2C9enzyme
QuinineCytochrome P450 2C19enzyme
QuinineCytochrome P450 2E1enzyme
QuinineCytochrome P450 3A7enzyme
QuinineSolute carrier family 22 member 2transporter
QuinineSolute carrier family 22 member 1transporter
QuinineSolute carrier family 22 member 5transporter
QuinineP-glycoprotein 1transporter
QuinineSolute carrier organic anion transporter family member 1A2transporter
QuinineSolute carrier family 22 member 4transporter
QuinineFe(II)-protoporphyrin IXtarget
QuinineSolute carrier organic anion transporter family member 1B1transporter
ChloroquineTumor necrosis factortarget
ChloroquineToll-like receptor 9target
ChloroquineGlutathione S-transferase A2target
ChloroquineCytochrome P450 2D6enzyme
ChloroquineCytochrome P450 3A4enzyme
ChloroquineCytochrome P450 1A1enzyme
ChloroquineCytochrome P450 2C8enzyme
ChloroquineCytochrome P450 3A5enzyme
ChloroquineGlutathione S-transferasetarget
ChloroquineP-glycoprotein 1transporter
ChloroquineSerum albumincarrier
Chloroquinealpha1-acid glycoproteincarrier
ChloroquineHigh mobility group protein B1target
ChloroquineGlutathione S-transferase Mu 1target
ChloroquineAngiotensin-converting enzyme 2target
Etacrynic acidSolute carrier family 12 member 1target
Etacrynic acidSodium/potassium-transporting ATPase subunit alpha-1target
Etacrynic acidGlutathione S-transferase A2enzyme
Etacrynic acidSerum albumincarrier
Etacrynic acidSolute carrier family 22 member 6transporter
Etacrynic acidLymphoid enhancer-binding factor 1target
Etacrynic acidGlutathione S-transferase Ptarget
VancomycinD-Ala-D-Ala moiety of NAM/NAG peptide subunits of peptidoglycantarget
VancomycinSerum albumincarrier
Vancomycinalpha1-acid glycoproteincarrier
VancomycinHistamine H1 receptorcarrier
Tobramycin30S ribosomal protein S12target
Tobramycin16S ribosomal RNAtarget
TobramycinAminoglycoside 2'-N-acetyltransferaseenzyme
Gentamicin30S ribosomal protein S12target
Gentamicin16S ribosomal RNAtarget
GentamicinLow-density lipoprotein receptor-related protein 2target
GentamicinSolute carrier family 22 member 6transporter
GentamicinNH(3)-dependent NAD(+) synthetasetarget
GentamicinDihydrofolate reductasetarget
Neomycin30S ribosomal protein S12target
Neomycin16S ribosomal RNAtarget
NeomycinExtracellular calcium-sensing receptortarget
Framycetin30S ribosomal protein S12target
Framycetin16S ribosomal RNAtarget
FramycetinC-X-C chemokine receptor type 4target
Netilmicin30S ribosomal protein S12target
Netilmicin16S ribosomal RNAtarget
Paromomycin16S ribosomal RNAtarget
Paromomycin30S ribosomal protein S10target
RibostamycinProtein disulfide-isomerasetarget
Ribostamycin30S ribosomal protein S12target
RibostamycinAminoglycoside N(6')-acetyltransferase type 1target
RibostamycinAminoglycoside 2'-N-acetyltransferasetarget
RibostamycinAminoglycoside 2'-N-acetyltransferaseenzyme
GeneticinOrnithine decarboxylasetarget
Apramycin16S ribosomal RNAtarget
Arbekacin30S ribosomal protein S12target
Puromycin60S ribosomal protein L10-liketarget
Puromycin60S ribosomal protein L13atarget
Puromycin60S ribosomal protein L23target
Puromycin60S ribosomal protein L15target
Puromycin60S ribosomal protein L19target
Puromycin60S ribosomal protein L23atarget
PuromycinProbable ribosome biogenesis protein RLP24target
Puromycin60S ribosomal protein L26-like 1target
Puromycin60S ribosomal protein L8target
Puromycin60S ribosomal protein L37target
Puromycin60S ribosomal protein L3target
Puromycin60S ribosomal protein L11target
PuromycinLeucyl/phenylalanyl-tRNA--protein transferasetarget
PlazomicinMultidrug and toxin extrusion protein 1transporter
PlazomicinMultidrug and toxin extrusion protein 2transporter
Plazomicin30S ribosomal protein S14target
Plazomicin30S ribosomal protein S11target
Botulinum toxin type ASynaptosomal-associated protein 25target
Botulinum toxin type ARho-related GTP-binding protein RhoBtarget
Botulinum Toxin Type BVesicle-associated membrane protein 1target
Botulinum Toxin Type BVesicle-associated membrane protein 2target
Botulinum Toxin Type BSynaptotagmin-2target
ClindamycinCytochrome P450 3A4enzyme
ClindamycinCytochrome P450 3A5enzyme
ClindamycinAlpha-1-acid glycoprotein 1carrier
ClindamycinP-glycoprotein 1transporter
Clindamycin50S ribosomal protein L1target
CyclosporineCalcium signal-modulating cyclophilin ligandtarget
CyclosporinePeptidyl-prolyl cis-trans isomerase Atarget
CyclosporineCalcineurin subunit B type 2target
CyclosporineCytochrome P450 3A5enzyme
CyclosporineCytochrome P450 3A4enzyme
CyclosporineP-glycoprotein 1transporter
CyclosporineBile salt export pumptransporter
CyclosporineIleal sodium/bile acid cotransportertransporter
CyclosporineSodium/bile acid cotransportertransporter
CyclosporineSolute carrier family 22 member 6transporter
CyclosporineMultidrug resistance-associated protein 7transporter
CyclosporineCanalicular multispecific organic anion transporter 1transporter
CyclosporineATP-binding cassette sub-family G member 2transporter
CyclosporineSolute carrier organic anion transporter family member 1B1transporter
CyclosporineCytochrome P450 2C19enzyme
CyclosporineCytochrome P450 2D6enzyme
CyclosporinePeptidyl-prolyl cis-trans isomerase F, mitochondrialtarget
CyclosporineSolute carrier organic anion transporter family member 1B3transporter
Lincomycin50S ribosomal protein L10target
Magnesium gluconateHexokinaseenzyme
Magnesium gluconateCreatine kinase B-typeenzyme
Magnesium gluconateTyrosine-protein kinase ABL1enzyme
Magnesium gluconateATP synthase subunit delta, mitochondrialenzyme
Magnesium gluconateAdenylate cyclase type 1enzyme
Magnesium gluconateGuanylate cyclase soluble subunit alpha-2enzyme
Magnesium gluconate6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1enzyme
Magnesium gluconatePhosphoribosylpyrophosphate synthetaseenzyme
Magnesium gluconateSodium/potassium-transporting ATPase subunit alpha-1enzyme
Magnesium acetateSodium/potassium-transporting ATPase subunit alpha-1target
Magnesium sulfateVoltage-dependent calcium channel gamma-1 subunittarget
Magnesium sulfateVoltage-dependent calcium channel subunit alpha-2/delta-1target
Magnesium sulfateVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
Magnesium sulfateVoltage-dependent L-type calcium channel subunit beta-1target
Magnesium sulfateVoltage-dependent L-type calcium channel subunit beta-2target
Magnesium sulfateVoltage-dependent L-type calcium channel subunit alpha-1Starget
Magnesium acetate tetrahydrateGlutamate (NMDA) receptortarget
Magnesium carbonateTransient receptor potential cation channel subfamily M member 6transporter
Magnesium carbonateSolute carrier family 41 member 3transporter
Magnesium carbonateMetal transporter CNNM2transporter
Magnesium carbonateTransient receptor potential cation channel subfamily M member 7transporter
Magnesium carbonateGlutamate (NMDA) receptortarget
Magnesium cationSodium/potassium-transporting ATPase subunit alpha-1target
Gentamicin C1a30S ribosomal protein S12target
Gentamicin C1a16S ribosomal RNAtarget
Viomycin16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyAtarget
MecamylamineNeuronal acetylcholine receptor subunit alpha-2target
MecamylamineNeuronal acetylcholine receptor subunit alpha-7target
MecamylamineNeuronal acetylcholine receptor subunit alpha-4target
MecamylamineNeuronal acetylcholine receptor subunit beta-2target
PiperacillinSolute carrier family 22 member 6transporter
PiperacillinPenicillin-binding protein 3target
PiperacillinPenicillin-binding protein 2Btarget
PiperacillinPenicillin-binding protein 2atarget
PiperacillinPenicillin-binding protein 1btarget
PiperacillinSolute carrier family 22 member 8transporter
DantroleneRyanodine receptor 1target
DantroleneThyroxine-binding globulincarrier