Dihydralazine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Name
Dihydralazine
Accession Number
DB12945
Type
Small Molecule
Groups
Approved, Investigational
Description

Dihydralazine is under investigation in clinical trial NCT00311974 (The Effect of Dihydralazine on Kidney Function and Hormones in Healthy Individuals).

Structure
Thumb
Synonyms
Not Available
Categories
UNII
PCU411F5L6
CAS number
484-23-1
Weight
Average: 190.21
Monoisotopic: 190.096694346
Chemical Formula
C8H10N6
InChI Key
VQKLRVZQQYVIJW-UHFFFAOYSA-N
InChI
InChI=1S/C8H10N6/c9-11-7-5-3-1-2-4-6(5)8(12-10)14-13-7/h1-4H,9-10H2,(H,11,13)(H,12,14)
IUPAC Name
1,4-dihydrazinylidene-1,2,3,4-tetrahydrophthalazine
SMILES
NN=C1NNC(=NN)C2=CC=CC=C12

Pharmacology

Indication
Not Available
Structured Indications
Not Available
Pharmacodynamics
Not Available
Mechanism of action
Not Available
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteractionDrug group
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline may increase the hypotensive activities of Dihydralazine.Experimental
AcebutololDihydralazine may increase the hypotensive activities of Acebutolol.Approved, Investigational
AcemetacinThe therapeutic efficacy of Dihydralazine can be decreased when used in combination with Acemetacin.Approved, Experimental, Investigational
AlfuzosinAlfuzosin may increase the hypotensive activities of Dihydralazine.Approved, Investigational
AliskirenDihydralazine may increase the hypotensive activities of Aliskiren.Approved, Investigational
AlprenololDihydralazine may increase the hypotensive activities of Alprenolol.Approved, Withdrawn
AmbrisentanDihydralazine may increase the hypotensive activities of Ambrisentan.Approved, Investigational
AmifostineDihydralazine may increase the hypotensive activities of Amifostine.Approved, Investigational
AmlodipineDihydralazine may increase the hypotensive activities of Amlodipine.Approved
AmphetamineAmphetamine may increase the hypotensive activities of Dihydralazine.Approved, Illicit, Investigational
AtenololDihydralazine may increase the hypotensive activities of Atenolol.Approved
AvanafilAvanafil may increase the antihypertensive activities of Dihydralazine.Approved
BarnidipineDihydralazine may increase the antihypertensive activities of Barnidipine.Approved
BenazeprilDihydralazine may increase the hypotensive activities of Benazepril.Approved, Investigational
BendroflumethiazideDihydralazine may increase the hypotensive activities of Bendroflumethiazide.Approved
BenmoxinBenmoxin may increase the hypotensive activities of Dihydralazine.Withdrawn
BepridilDihydralazine may increase the hypotensive activities of Bepridil.Approved, Withdrawn
BetaxololDihydralazine may increase the hypotensive activities of Betaxolol.Approved, Investigational
BethanidineBethanidine may increase the hypotensive activities of Dihydralazine.Approved
BietaserpineDihydralazine may increase the hypotensive activities of Bietaserpine.Experimental
BimatoprostDihydralazine may increase the hypotensive activities of Bimatoprost.Approved, Investigational
BisoprololDihydralazine may increase the hypotensive activities of Bisoprolol.Approved
BosentanBosentan may increase the hypotensive activities of Dihydralazine.Approved, Investigational
BQ-123Dihydralazine may increase the hypotensive activities of BQ-123.Investigational
BretyliumDihydralazine may increase the hypotensive activities of Bretylium.Approved
BrimonidineBrimonidine may increase the antihypertensive activities of Dihydralazine.Approved
BrofaromineBrofaromine may increase the hypotensive activities of Dihydralazine.Experimental
BupranololDihydralazine may increase the hypotensive activities of Bupranolol.Approved
CadralazineDihydralazine may increase the hypotensive activities of Cadralazine.Experimental
CafedrineDihydralazine may increase the hypotensive activities of Cafedrine.Investigational
CandesartanDihydralazine may increase the hypotensive activities of Candesartan.Experimental
Candesartan cilexetilDihydralazine may increase the hypotensive activities of Candesartan cilexetil.Approved
CandoxatrilDihydralazine may increase the hypotensive activities of Candoxatril.Experimental
CaptoprilDihydralazine may increase the hypotensive activities of Captopril.Approved
CaroxazoneCaroxazone may increase the hypotensive activities of Dihydralazine.Withdrawn
CarteololDihydralazine may increase the hypotensive activities of Carteolol.Approved
CarvedilolDihydralazine may increase the hypotensive activities of Carvedilol.Approved, Investigational
CeliprololDihydralazine may increase the hypotensive activities of Celiprolol.Approved, Investigational
ChlorothiazideDihydralazine may increase the hypotensive activities of Chlorothiazide.Approved, Vet Approved
ChlorthalidoneDihydralazine may increase the hypotensive activities of Chlorthalidone.Approved
CicletanineDihydralazine may increase the hypotensive activities of Cicletanine.Investigational
CilazaprilDihydralazine may increase the hypotensive activities of Cilazapril.Approved
ClonidineClonidine may increase the hypotensive activities of Dihydralazine.Approved
CloranololDihydralazine may increase the hypotensive activities of Cloranolol.Experimental
CryptenamineDihydralazine may increase the hypotensive activities of Cryptenamine.Approved
CyclopenthiazideDihydralazine may increase the hypotensive activities of Cyclopenthiazide.Experimental
CyclothiazideDihydralazine may increase the hypotensive activities of Cyclothiazide.Approved
DebrisoquinDebrisoquin may increase the hypotensive activities of Dihydralazine.Approved, Investigational
DelaprilDihydralazine may increase the hypotensive activities of Delapril.Experimental
DeserpidineDihydralazine may increase the hypotensive activities of Deserpidine.Approved
DiazoxideDiazoxide may increase the hypotensive activities of Dihydralazine.Approved
DiethylnorspermineDihydralazine may increase the hypotensive activities of Diethylnorspermine.Investigational
DiltiazemDihydralazine may increase the hypotensive activities of Diltiazem.Approved, Investigational
DorzolamideDihydralazine may increase the hypotensive activities of Dorzolamide.Approved
DoxazosinDoxazosin may increase the hypotensive activities of Dihydralazine.Approved
EfonidipineDihydralazine may increase the hypotensive activities of Efonidipine.Approved, Investigational
EnalaprilDihydralazine may increase the hypotensive activities of Enalapril.Approved, Vet Approved
EnalaprilatDihydralazine may increase the hypotensive activities of Enalaprilat.Approved
EndralazineDihydralazine may increase the hypotensive activities of Endralazine.Experimental
EpanololDihydralazine may increase the hypotensive activities of Epanolol.Experimental
EpoprostenolDihydralazine may increase the hypotensive activities of Epoprostenol.Approved
EprosartanDihydralazine may increase the hypotensive activities of Eprosartan.Approved
FelodipineDihydralazine may increase the hypotensive activities of Felodipine.Approved, Investigational
FenoldopamDihydralazine may increase the hypotensive activities of Fenoldopam.Approved
Ferulic acidDihydralazine may increase the hypotensive activities of Ferulic acid.Experimental
FosinoprilDihydralazine may increase the hypotensive activities of Fosinopril.Approved
FurazolidoneFurazolidone may increase the hypotensive activities of Dihydralazine.Approved, Investigational, Vet Approved
GuanabenzDihydralazine may increase the hypotensive activities of Guanabenz.Approved, Investigational
GuanadrelDihydralazine may increase the hypotensive activities of Guanadrel.Approved
GuanazodineDihydralazine may increase the hypotensive activities of Guanazodine.Experimental
GuanethidineDihydralazine may increase the hypotensive activities of Guanethidine.Approved
GuanfacineGuanfacine may increase the hypotensive activities of Dihydralazine.Approved, Investigational
GuanoclorDihydralazine may increase the hypotensive activities of Guanoclor.Experimental
GuanoxabenzDihydralazine may increase the hypotensive activities of Guanoxabenz.Experimental
GuanoxanDihydralazine may increase the hypotensive activities of Guanoxan.Experimental
HarmalineHarmaline may increase the hypotensive activities of Dihydralazine.Experimental
HexamethoniumDihydralazine may increase the hypotensive activities of Hexamethonium.Experimental
HydracarbazineHydracarbazine may increase the hypotensive activities of Dihydralazine.Experimental
HydralazineHydralazine may increase the hypotensive activities of Dihydralazine.Approved
HydrochlorothiazideDihydralazine may increase the hypotensive activities of Hydrochlorothiazide.Approved, Vet Approved
HydroflumethiazideDihydralazine may increase the hypotensive activities of Hydroflumethiazide.Approved, Investigational
IloprostIloprost may increase the hypotensive activities of Dihydralazine.Approved, Investigational
ImidaprilDihydralazine may increase the hypotensive activities of Imidapril.Investigational
IndapamideDihydralazine may increase the hypotensive activities of Indapamide.Approved
IndenololDihydralazine may increase the hypotensive activities of Indenolol.Withdrawn
IndoraminIndoramin may increase the hypotensive activities of Dihydralazine.Withdrawn
IproclozideIproclozide may increase the hypotensive activities of Dihydralazine.Withdrawn
IproniazidIproniazid may increase the hypotensive activities of Dihydralazine.Withdrawn
IrbesartanDihydralazine may increase the hypotensive activities of Irbesartan.Approved, Investigational
IsocarboxazidIsocarboxazid may increase the hypotensive activities of Dihydralazine.Approved
IsradipineDihydralazine may increase the hypotensive activities of Isradipine.Approved, Investigational
KetanserinKetanserin may increase the hypotensive activities of Dihydralazine.Investigational
LabetalolDihydralazine may increase the hypotensive activities of Labetalol.Approved
LacidipineDihydralazine may increase the hypotensive activities of Lacidipine.Approved, Investigational
LatanoprostDihydralazine may increase the hypotensive activities of Latanoprost.Approved, Investigational
LercanidipineDihydralazine may increase the hypotensive activities of Lercanidipine.Approved, Investigational
LinsidomineDihydralazine may increase the hypotensive activities of Linsidomine.Experimental
LisinoprilDihydralazine may increase the hypotensive activities of Lisinopril.Approved, Investigational
LofexidineDihydralazine may increase the hypotensive activities of Lofexidine.Approved, Investigational
LosartanDihydralazine may increase the hypotensive activities of Losartan.Approved
MacitentanDihydralazine may increase the hypotensive activities of Macitentan.Approved
ManidipineDihydralazine may increase the hypotensive activities of Manidipine.Approved, Investigational
MebanazineMebanazine may increase the hypotensive activities of Dihydralazine.Withdrawn
MecamylamineMecamylamine may increase the hypotensive activities of Dihydralazine.Approved, Investigational
MethoserpidineDihydralazine may increase the hypotensive activities of Methoserpidine.Experimental
MethyldopaDihydralazine may increase the hypotensive activities of Methyldopa.Approved
Methylene blueMethylene blue may increase the hypotensive activities of Dihydralazine.Approved, Investigational
MethylphenidateMethylphenidate may decrease the antihypertensive activities of Dihydralazine.Approved, Investigational
MetipranololDihydralazine may increase the hypotensive activities of Metipranolol.Approved
MetolazoneDihydralazine may increase the hypotensive activities of Metolazone.Approved
MetoprololDihydralazine may increase the hypotensive activities of Metoprolol.Approved, Investigational
MetyrosineDihydralazine may increase the hypotensive activities of Metyrosine.Approved
MibefradilDihydralazine may increase the hypotensive activities of Mibefradil.Investigational, Withdrawn
MinaprineMinaprine may increase the hypotensive activities of Dihydralazine.Approved
MinoxidilMinoxidil may increase the hypotensive activities of Dihydralazine.Approved, Investigational
MirodenafilMirodenafil may increase the antihypertensive activities of Dihydralazine.Investigational
MoclobemideMoclobemide may increase the hypotensive activities of Dihydralazine.Approved, Investigational
MoexiprilDihydralazine may increase the hypotensive activities of Moexipril.Approved
MolsidomineMolsidomine may increase the hypotensive activities of Dihydralazine.Approved, Investigational
MoxonidineMoxonidine may increase the hypotensive activities of Dihydralazine.Approved, Investigational
MuzolimineDihydralazine may increase the hypotensive activities of Muzolimine.Experimental
NadololDihydralazine may increase the hypotensive activities of Nadolol.Approved
NaftopidilDihydralazine may increase the hypotensive activities of Naftopidil.Investigational
NebivololDihydralazine may increase the hypotensive activities of Nebivolol.Approved, Investigational
NialamideNialamide may increase the hypotensive activities of Dihydralazine.Withdrawn
NicardipineDihydralazine may increase the hypotensive activities of Nicardipine.Approved, Investigational
NicorandilDihydralazine may increase the hypotensive activities of Nicorandil.Approved, Investigational
NiguldipineDihydralazine may increase the hypotensive activities of Niguldipine.Experimental
NilvadipineDihydralazine may increase the hypotensive activities of Nilvadipine.Approved, Investigational
NimodipineDihydralazine may increase the hypotensive activities of Nimodipine.Approved, Investigational
NisoldipineDihydralazine may increase the hypotensive activities of Nisoldipine.Approved
NitrendipineDihydralazine may increase the hypotensive activities of Nitrendipine.Approved, Investigational
NitroprussideNitroprusside may increase the hypotensive activities of Dihydralazine.Approved, Investigational
ObinutuzumabDihydralazine may increase the hypotensive activities of Obinutuzumab.Approved, Investigational
OctamoxinOctamoxin may increase the hypotensive activities of Dihydralazine.Withdrawn
OlmesartanDihydralazine may increase the hypotensive activities of Olmesartan.Approved, Investigational
OmapatrilatDihydralazine may increase the hypotensive activities of Omapatrilat.Investigational
OxprenololDihydralazine may increase the hypotensive activities of Oxprenolol.Approved
PargylinePargyline may increase the hypotensive activities of Dihydralazine.Approved
PenbutololDihydralazine may increase the hypotensive activities of Penbutolol.Approved, Investigational
PentoliniumDihydralazine may increase the hypotensive activities of Pentolinium.Approved
PentoxifyllinePentoxifylline may increase the hypotensive activities of Dihydralazine.Approved, Investigational
PerindoprilDihydralazine may increase the hypotensive activities of Perindopril.Approved
PhenelzinePhenelzine may increase the hypotensive activities of Dihydralazine.Approved
PheniprazinePheniprazine may increase the hypotensive activities of Dihydralazine.Withdrawn
PhenoxybenzamineDihydralazine may increase the hypotensive activities of Phenoxybenzamine.Approved
PhenoxypropazinePhenoxypropazine may increase the hypotensive activities of Dihydralazine.Withdrawn
PhentolamineDihydralazine may increase the hypotensive activities of Phentolamine.Approved
PinacidilPinacidil may increase the hypotensive activities of Dihydralazine.Approved
PindololDihydralazine may increase the hypotensive activities of Pindolol.Approved, Investigational
PirlindolePirlindole may increase the hypotensive activities of Dihydralazine.Approved
PivhydrazinePivhydrazine may increase the hypotensive activities of Dihydralazine.Withdrawn
Platelet Activating FactorDihydralazine may increase the hypotensive activities of Platelet Activating Factor.Experimental
PolythiazideDihydralazine may increase the hypotensive activities of Polythiazide.Approved
PrazosinPrazosin may increase the hypotensive activities of Dihydralazine.Approved
ProcarbazineProcarbazine may increase the hypotensive activities of Dihydralazine.Approved, Investigational
PropranololDihydralazine may increase the hypotensive activities of Propranolol.Approved, Investigational
QuinaprilDihydralazine may increase the hypotensive activities of Quinapril.Approved, Investigational
QuinineQuinine may increase the hypotensive activities of Dihydralazine.Approved
RamiprilDihydralazine may increase the hypotensive activities of Ramipril.Approved
RasagilineRasagiline may increase the hypotensive activities of Dihydralazine.Approved
RemikirenDihydralazine may increase the hypotensive activities of Remikiren.Approved
RescinnamineDihydralazine may increase the hypotensive activities of Rescinnamine.Approved
ReserpineReserpine may increase the hypotensive activities of Dihydralazine.Approved, Investigational
RilmenidineRilmenidine may increase the hypotensive activities of Dihydralazine.Approved, Investigational
RiociguatDihydralazine may increase the hypotensive activities of Riociguat.Approved
RituximabDihydralazine may increase the hypotensive activities of Rituximab.Approved
SafrazineSafrazine may increase the hypotensive activities of Dihydralazine.Withdrawn
SaprisartanDihydralazine may increase the hypotensive activities of Saprisartan.Experimental
SelegilineSelegiline may increase the hypotensive activities of Dihydralazine.Approved, Investigational, Vet Approved
SelexipagDihydralazine may increase the hypotensive activities of Selexipag.Approved
SildenafilSildenafil may increase the antihypertensive activities of Dihydralazine.Approved, Investigational
SitaxentanDihydralazine may increase the hypotensive activities of Sitaxentan.Approved, Investigational, Withdrawn
SpiraprilDihydralazine may increase the hypotensive activities of Spirapril.Approved
TadalafilTadalafil may increase the antihypertensive activities of Dihydralazine.Approved, Investigational
TalinololDihydralazine may increase the hypotensive activities of Talinolol.Investigational
TelmisartanDihydralazine may increase the hypotensive activities of Telmisartan.Approved, Investigational
TemocaprilDihydralazine may increase the hypotensive activities of Temocapril.Experimental, Investigational
TerlipressinDihydralazine may increase the hypotensive activities of Terlipressin.Approved, Investigational
TetrahydropalmatineDihydralazine may increase the hypotensive activities of Tetrahydropalmatine.Investigational
TheodrenalineDihydralazine may increase the hypotensive activities of Theodrenaline.Investigational
TiboloneDihydralazine may increase the hypotensive activities of Tibolone.Approved, Investigational
TicrynafenDihydralazine may increase the hypotensive activities of Ticrynafen.Withdrawn
TimololDihydralazine may increase the hypotensive activities of Timolol.Approved
TolazolineDihydralazine may increase the hypotensive activities of Tolazoline.Approved, Vet Approved
TolonidineDihydralazine may increase the hypotensive activities of Tolonidine.Experimental
ToloxatoneToloxatone may increase the hypotensive activities of Dihydralazine.Approved
TorasemideDihydralazine may increase the hypotensive activities of Torasemide.Approved
TrandolaprilDihydralazine may increase the hypotensive activities of Trandolapril.Approved
Trans-2-PhenylcyclopropylamineTrans-2-Phenylcyclopropylamine may increase the hypotensive activities of Dihydralazine.Experimental
TranylcypromineTranylcypromine may increase the hypotensive activities of Dihydralazine.Approved, Investigational
TravoprostDihydralazine may increase the hypotensive activities of Travoprost.Approved
TreprostinilDihydralazine may increase the hypotensive activities of Treprostinil.Approved, Investigational
TrichlormethiazideDihydralazine may increase the hypotensive activities of Trichlormethiazide.Approved, Vet Approved
TrimazosinTrimazosin may increase the hypotensive activities of Dihydralazine.Experimental
TrimethaphanTrimethaphan may increase the hypotensive activities of Dihydralazine.Approved, Investigational
UdenafilUdenafil may increase the antihypertensive activities of Dihydralazine.Approved, Investigational
UnoprostoneDihydralazine may increase the hypotensive activities of Unoprostone.Approved, Investigational
UrapidilDihydralazine may increase the hypotensive activities of Urapidil.Investigational
ValsartanDihydralazine may increase the hypotensive activities of Valsartan.Approved, Investigational
VardenafilVardenafil may increase the antihypertensive activities of Dihydralazine.Approved
VincamineDihydralazine may increase the hypotensive activities of Vincamine.Experimental
VinpocetineDihydralazine may increase the hypotensive activities of Vinpocetine.Investigational
XipamideDihydralazine may increase the hypotensive activities of Xipamide.Experimental
XylometazolineDihydralazine may increase the hypotensive activities of Xylometazoline.Approved, Investigational
YohimbineYohimbine may decrease the antihypertensive activities of Dihydralazine.Approved, Investigational, Vet Approved
ZofenoprilDihydralazine may increase the hypotensive activities of Zofenopril.Experimental
Food Interactions
Not Available

References

General References
Not Available
External Links
PubChem Compound
10230
PubChem Substance
347829088
ChemSpider
9813
BindingDB
50088433
ChEBI
134841
ChEMBL
CHEMBL35505
Wikipedia
Dihydralazine
ATC Codes
C02LG01 — Dihydralazine and diureticsC02DB01 — DihydralazineC02LG51 — Dihydralazine and diuretics, combinations with other drugs

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedNot AvailableHealthy Volunteers1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.961 mg/mLALOGPS
logP-0.16ALOGPS
logP-0.21ChemAxon
logS-2.3ALOGPS
pKa (Strongest Acidic)10.38ChemAxon
pKa (Strongest Basic)-1.2ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area100.82 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity76.93 m3·mol-1ChemAxon
Polarizability19.08 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Taxonomy

Description
This compound belongs to the class of organic compounds known as phthalazines. These are compounds containing a phthalazine moiety, which consists of a benzene ring fused to a pyridazine, forming a 2,3-benzodiazine skeleton.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Diazanaphthalenes
Sub Class
Benzodiazines
Direct Parent
Phthalazines
Alternative Parents
Pyridazines and derivatives / Imidolactams / Benzenoids / Heteroaromatic compounds / Azacyclic compounds / Organopnictogen compounds / Hydrocarbon derivatives / Hydrazines and derivatives
Substituents
Phthalazine / Imidolactam / Benzenoid / Pyridazine / Heteroaromatic compound / Azacycle / Organic nitrogen compound / Organopnictogen compound / Hydrocarbon derivative / Organonitrogen compound
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available

Drug created on October 20, 2016 19:32 / Updated on February 08, 2018 18:17