Opiate Alkaloids

Alkaloids found in OPIUM from PAPAVER that induce analgesic and narcotic effects by action upon OPIOID RECEPTORS.
DrugDrug NameDrug Description
DB00295MorphineAn opioid agonist used for the relief of moderate to severe acute and chronic pain.
DB00318CodeineAn opioid analgesic used to treat moderate to severe pain when the use of an opioid is indicated.
DB00327HydromorphoneAn opioid analgesic used to treat moderate to severe pain when the use of an opioid is indicated.
DB00497OxycodoneAn opioid used in the management of moderate to severe pain.
DB00504LevallorphanFor the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids.
DB00514DextromethorphanAn NMDA receptor antagonist used to treat cases of dry cough.
DB00611ButorphanolAn opioid agonist-antagonist used to treat moderate to severe pain.
DB00652PentazocineAn analgesic used to treat moderate to severe pain.
DB00704NaltrexoneA narcotic antagonist used in opioid overdose.
DB00844NalbuphineAn opioid agonist-antagonist used to treat pain, for pre and postoperative analgesia, and for analgesia in labor and delivery.
DB00854LevorphanolAn opioid analgesic used to treat moderate to severe pain.
DB00921BuprenorphineA partial opioid agonist used for management of severe pain that is not responsive to alternative treatments. Also used for maintenance treatment of opioid addiction.
DB00956HydrocodoneAn opioid agonist used as an analgesic and antitussive agent.
DB01113PapaverineAn alkaloid used to treat many types of smooth muscle spasms such as "vascular spasms" associated with acute myocardial infarction and angina pectoris, as well as "visceral spasms".
DB01183NaloxoneAn opioid receptor antagonist used to rapidly reverse an opioid overdose. Also included in some drug formulations as an abuse deterrent to prevent injection.
DB01192OxymorphoneAn opioid analgesic used in the management of moderate-to-severe pain and for analgesic therapies.
DB014415-Methoxy-N,N-diisopropyltryptamine5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) is a tryptamine derivative and shares many similarities with schedule I tryptamine hallucinogens such as alpha-ethyltryptamine, N,N-dimethyltryptamine, N,N-diethyltryptamine, bufotenine, psilocybin and psilocin. Since 1999, there has been a...
DB01450DihydroetorphineNot Available
DB01452DiamorphineAn opioid analgesic agent used in the relief of severe pain associated with surgical procedures, myocardial infarction or pain in the terminally ill and for the relief of dyspnea in acute pulmonary edema.
DB01466EthylmorphineEthylmorphine is an analgesic used for pain relief.
DB01480CyprenorphineNot Available
DB01497EtorphineEtorphine is only available for its use in veterinary. This main usage is related to the immobilization of large mammals.
DB01531DesomorphineNot Available
DB01547DrotebanolNot Available
DB01548DiprenorphineDiprenorphine is indicated to reverse the effects of powerful opioids including etorphine and carfentanil, often used for tranquilizing large animals. This drug is not approved for use in humans.
DB01551DihydrocodeineAn opioid analgesic agent used for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.
DB01565DihydromorphineDihydromorphine is an opioid analgesic used for moderate to severe pain relief.
DB06174NoscapineInvestigated for use/treatment in lymphoma (non-hodgkin's), leukemia (lymphoid), cancer/tumors (unspecified), and multiple myeloma.
DB06230NalmefeneAn opioid antagonist used in conjunction with psychosocial support to help adults with alcohol dependence reduce alcohol consumption.
DB06751DrotaverineUsed in the treatment of functional bowel disorders and alleviating pain in renal colic.
DB06800MethylnaltrexoneA μ-opioid antagonist used for the treatment of opioid-induced constipation in palliative patients that are inadequately responding to laxative therapy.
DB09049NaloxegolA peripherally-selective opioid antagonist used to treat opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain.
DB09209PholcodinePholcodine is indicated as a cough suppressant for the temporary relief of non-productive dry cough. It is stated to present a required label indication of "temporary relief of dry cough."...
DB11490NalorphineUsed to reverse opioid overdose.
DB12251MoxaverineMoxaverine has been investigated for the treatment of Retina, Ocular Physiology, and Regional Blood Flow.
DB12543SamidorphanSamidorphan has been used in trials studying the treatment of Schizophrenia, Alcohol Dependence, and Binge Eating Disorder.
DB13454NicomorphineNot Annotated
DB13471NalfurafineNot Annotated
DB13606PhenazocineNot Annotated
DB13810DimemorfanNot Annotated
DB14682DextrorphanNot Annotated
DB06409Morphine glucuronideInvestigated for use/treatment in pain (acute or chronic).
DB11691NaldemedineAn opioid antagonist used to to treat opioid-induced constipation.
DB14146LoxicodegolLoxicodegol was developed as an opioid analgesic with low abuse potential for use in treating chronic pain . An application has been filed for FDA approval of Loxicodegol for use...
DrugDrug NameTargetType
DB00295MorphineMu-type opioid receptortarget
DB00295MorphineDelta-type opioid receptortarget
DB00295MorphineKappa-type opioid receptortarget
DB00295MorphineP-glycoprotein 1transporter
DB00295MorphineCytochrome P450 2C8enzyme
DB00295MorphineCytochrome P450 3A4enzyme
DB00295MorphineUDP-glucuronosyltransferase 2B7enzyme
DB00295MorphineUDP-glucuronosyltransferase 1-1enzyme
DB00295MorphineUDP-glucuronosyltransferase 1-8enzyme
DB00295MorphineUDP-glucuronosyltransferase 2B15enzyme
DB00295MorphineUDP-glucuronosyltransferase 2B4enzyme
DB00295MorphineUDP-glucuronosyltransferase 1-3enzyme
DB00295MorphineLymphocyte antigen 96target
DB00295MorphineSerum albumincarrier
DB00318CodeineMu-type opioid receptortarget
DB00318CodeineDelta-type opioid receptortarget
DB00318CodeineKappa-type opioid receptortarget
DB00318CodeineCytochrome P450 2D6enzyme
DB00318CodeineCytochrome P450 3A4enzyme
DB00318CodeineSolute carrier family 22 member 1transporter
DB00318CodeineUDP-glucuronosyltransferase 2B7enzyme
DB00318CodeineUDP-glucuronosyltransferase 2B4enzyme
DB00327HydromorphoneMu-type opioid receptortarget
DB00327HydromorphoneDelta-type opioid receptortarget
DB00327HydromorphoneKappa-type opioid receptortarget
DB00327HydromorphoneCytochrome P450 2C9enzyme
DB00327HydromorphoneUDP-glucuronosyltransferase 1-3enzyme
DB00327HydromorphoneUDP-glucuronosyltransferase 2B7enzyme
DB00327HydromorphoneSerum albumincarrier
DB00497OxycodoneMu-type opioid receptortarget
DB00497OxycodoneKappa-type opioid receptortarget
DB00497OxycodoneDelta-type opioid receptortarget
DB00497OxycodoneCytochrome P450 2D6enzyme
DB00497OxycodoneCytochrome P450 3A4enzyme
DB00497OxycodoneCytochrome P450 3A5enzyme
DB00497OxycodoneSerum albumincarrier
DB00497Oxycodonealpha1-acid glycoproteincarrier
DB00504LevallorphanMu-type opioid receptortarget
DB00514DextromethorphanSigma non-opioid intracellular receptor 1target
DB00514DextromethorphanHCG20471, isoform CRA_ctarget
DB00514DextromethorphanNeuronal acetylcholine receptor subunit alpha-2target
DB00514DextromethorphanSodium-dependent serotonin transportertarget
DB00514DextromethorphanGlutamate receptor ionotropic, NMDA 3Atarget
DB00514DextromethorphanCytochrome P450 2D6enzyme
DB00514DextromethorphanCytochrome P450 3A4enzyme
DB00514DextromethorphanCytochrome P450 3A7enzyme
DB00514DextromethorphanCytochrome P450 2C9enzyme
DB00514DextromethorphanCytochrome P450 2B6enzyme
DB00514DextromethorphanCytochrome P450 2C19enzyme
DB00514DextromethorphanMembrane-associated progesterone receptor component 1target
DB00514DextromethorphanNeuronal acetylcholine receptor subunit alpha-3target
DB00514DextromethorphanNeuronal acetylcholine receptor subunit alpha-4target
DB00514DextromethorphanNeuronal acetylcholine receptor subunit beta-4target
DB00514DextromethorphanNeuronal acetylcholine receptor subunit beta-2target
DB00514DextromethorphanNeuronal acetylcholine receptor subunit alpha-7target
DB00514DextromethorphanMu-type opioid receptortarget
DB00514DextromethorphanDelta-type opioid receptortarget
DB00514DextromethorphanKappa-type opioid receptortarget
DB00514DextromethorphanNADPH oxidasetarget
DB00514DextromethorphanSodium-dependent noradrenaline transportertarget
DB00611ButorphanolKappa-type opioid receptortarget
DB00611ButorphanolMu-type opioid receptortarget
DB00611ButorphanolDelta-type opioid receptortarget
DB00652PentazocineMu-type opioid receptortarget
DB00652PentazocineKappa-type opioid receptortarget
DB00652PentazocineSigma non-opioid intracellular receptor 1target
DB00704NaltrexoneMu-type opioid receptortarget
DB00704NaltrexoneKappa-type opioid receptortarget
DB00704NaltrexoneDelta-type opioid receptortarget
DB00704NaltrexoneHCG20471, isoform CRA_ctarget
DB00704NaltrexoneUDP-glucuronosyltransferase 1-1enzyme
DB00844NalbuphineKappa-type opioid receptortarget
DB00844NalbuphineMu-type opioid receptortarget
DB00844NalbuphineDelta-type opioid receptortarget
DB00854LevorphanolMu-type opioid receptortarget
DB00854LevorphanolDelta-type opioid receptortarget
DB00854LevorphanolKappa-type opioid receptortarget
DB00921BuprenorphineKappa-type opioid receptortarget
DB00921BuprenorphineMu-type opioid receptortarget
DB00921BuprenorphineCytochrome P450 3A4enzyme
DB00921BuprenorphineCytochrome P450 2D6enzyme
DB00921BuprenorphineP-glycoprotein 1transporter
DB00921BuprenorphineATP-binding cassette sub-family G member 2transporter
DB00921BuprenorphineCytochrome P450 2C9enzyme
DB00921BuprenorphineCytochrome P450 3A5enzyme
DB00921BuprenorphineCytochrome P450 2C8enzyme
DB00921BuprenorphineCytochrome P450 3A7enzyme
DB00921BuprenorphineDelta-type opioid receptortarget
DB00921BuprenorphineCytochrome P450 2C18enzyme
DB00921BuprenorphineCytochrome P450 2C19enzyme
DB00921BuprenorphineNociceptin receptortarget
DB00956HydrocodoneMu-type opioid receptortarget
DB00956HydrocodoneDelta-type opioid receptortarget
DB00956HydrocodoneCytochrome P450 3A4enzyme
DB00956HydrocodoneCytochrome P450 2D6enzyme
DB00956HydrocodoneCytochrome P450 2B6enzyme
DB00956HydrocodoneCytochrome P450 2C19enzyme
DB00956HydrocodoneSigma non-opioid intracellular receptor 1target
DB01113PapaverinecAMP-specific 3',5'-cyclic phosphodiesterase 4Btarget
DB01113PapaverinecAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10Atarget
DB01183NaloxoneMu-type opioid receptortarget
DB01183NaloxoneEstrogen receptor alphatarget
DB01183NaloxoneCyclic AMP-responsive element-binding protein 1target
DB01183NaloxoneDelta-type opioid receptortarget
DB01183NaloxoneSolute carrier organic anion transporter family member 1A2transporter
DB01183NaloxoneP-glycoprotein 1transporter
DB01183NaloxoneKappa-type opioid receptortarget
DB01183NaloxoneCytochrome P450 3A4enzyme
DB01183NaloxoneSerum albumincarrier
DB01183NaloxoneToll-like receptor 4target
DB01183NaloxoneLiver carboxylesterase 1target
DB01183NaloxoneUDP-glucuronosyltransferase 1-1enzyme
DB01192OxymorphoneMu-type opioid receptortarget
DB01192OxymorphoneCytochrome P450 2D6enzyme
DB01192OxymorphoneDelta-type opioid receptortarget
DB01192OxymorphoneCytochrome P450 3A4enzyme
DB01452DiamorphineMu-type opioid receptortarget
DB01452DiamorphineKappa-type opioid receptortarget
DB01452DiamorphineDelta-type opioid receptortarget
DB01452DiamorphineLiver carboxylesterase 1target
DB01452DiamorphineThyroxine-binding globulincarrier
DB01466EthylmorphineCytochrome P450 2D6enzyme
DB01466EthylmorphineNADPH--cytochrome P450 reductaseenzyme
DB01466EthylmorphineMu-type opioid receptortarget
DB01466EthylmorphineCytochrome P450 2B6enzyme
DB01466EthylmorphineCytochrome P450 3A4enzyme
DB01497EtorphineE3 ubiquitin-protein ligase TRIM13target
DB01497EtorphinePro-opiomelanocortintarget
DB01497EtorphineMu-type opioid receptortarget
DB01497EtorphineDelta-type opioid receptortarget
DB01497EtorphineKappa-type opioid receptortarget
DB01497EtorphineNociceptin receptortarget
DB01548DiprenorphineE3 ubiquitin-protein ligase TRIM13target
DB01548DiprenorphineDelta-type opioid receptortarget
DB01548DiprenorphineKappa-type opioid receptortarget
DB01548DiprenorphineMu-type opioid receptortarget
DB01551DihydrocodeineCytochrome P450 2D6enzyme
DB01551DihydrocodeineCytochrome P450 3A4enzyme
DB01565DihydromorphineE3 ubiquitin-protein ligase TRIM13target
DB01565DihydromorphinePro-opiomelanocortintarget
DB01565DihydromorphineMu-type opioid receptortarget
DB01565DihydromorphineDelta-type opioid receptortarget
DB01565DihydromorphineKappa-type opioid receptortarget
DB06174NoscapineSigma non-opioid intracellular receptor 1target
DB06174NoscapineCytochrome P450 2C9enzyme
DB06174NoscapineCytochrome P450 3A4enzyme
DB06230NalmefeneMu-type opioid receptortarget
DB06230NalmefeneKappa-type opioid receptortarget
DB06230NalmefeneDelta-type opioid receptortarget
DB06230NalmefeneUDP-glucuronosyltransferase 2B7enzyme
DB06230NalmefeneUDP-glucuronosyltransferase 1-3enzyme
DB06230NalmefeneUDP-glucuronosyltransferase 1-8enzyme
DB06751DrotaverinecAMP-specific 3',5'-cyclic phosphodiesterase 4Atarget
DB06751DrotaverineVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB06800MethylnaltrexoneMu-type opioid receptortarget
DB06800MethylnaltrexoneKappa-type opioid receptortarget
DB09049NaloxegolCytochrome P450 3A4enzyme
DB09049NaloxegolCytochrome P450 2D6enzyme
DB09049NaloxegolCytochrome P450 2C19enzyme
DB09049NaloxegolMu-type opioid receptortarget
DB09209PholcodineMu-type opioid receptortarget
DB09209PholcodineKappa-type opioid receptortarget
DB09209PholcodineDelta-type opioid receptortarget
DB06409Morphine glucuronideMu-type opioid receptortarget
DB06409Morphine glucuronideDelta-type opioid receptortarget
DB06409Morphine glucuronideKappa-type opioid receptortarget
DB11691NaldemedineCytochrome P450 3A Subfamilyenzyme
DB11691NaldemedineUDP-glucuronosyltransferase 1-3enzyme
DB11691NaldemedineMu-type opioid receptortarget
DB11691NaldemedineDelta-type opioid receptortarget
DB11691NaldemedineKappa-type opioid receptortarget
DB11691NaldemedineATP-binding cassette sub-family B member 5transporter
DB14146LoxicodegolMu-type opioid receptortarget
DB14146LoxicodegolDelta-type opioid receptortarget
DB14146LoxicodegolKappa-type opioid receptortarget
DB14146LoxicodegolP-glycoprotein 1transporter