Irritability

Also known as: Irritable Mood / Fussiness / Irritable / Feeling irritated / Irritable symptom

DrugDrug NameDrug Description
DB01238AripiprazoleAripiprazole is an atypical antipsychotic orally indicated for treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's[Label]. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania[Label]. Aripiprazole exerts its effects through agonism of dopaminic and 5-HT1A receptors and antagonism of alpha adrenergic and 5-HT2A receptors[Label,A4393]. Aripiprazole was given FDA approval on November 15, 2002[L6136].
DB00734RisperidoneRisperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia, bipolar mania, and as an adjunct in severe depression for example. It is one of the most widely used SGAs. Schizophrenia and various mood disorders are thought to be caused by an excess of dopaminergic D2 and serotonergic 5-HT2A activity, resulting in overactivity of central mesolimbic pathways and mesocortical pathways, respectively.[L1212, L1213] Risperidone is thought to reduce this overactivity through inhibition of dopaminergic D2 receptors and serotonergic 5-HT2A receptors in the brain.[L1213, A1115]. Risperidone binds with a very high affinity to 5-HT2A receptors, approximately 10-20 fold greater than the drug's binding affinity to D2 receptors [L1212, L1213, A1115].
DrugDrug NameTargetType
DB01238AripiprazoleDopamine D2 receptortarget
DB01238Aripiprazole5-hydroxytryptamine receptor 1Atarget
DB01238Aripiprazole5-hydroxytryptamine receptor 2Atarget
DB01238AripiprazoleCytochrome P450 3A4enzyme
DB01238AripiprazoleCytochrome P450 2D6enzyme
DB01238Aripiprazole5-hydroxytryptamine receptor 1Btarget
DB01238Aripiprazole5-hydroxytryptamine receptor 1Dtarget
DB01238Aripiprazole5-hydroxytryptamine receptor 1Etarget
DB01238AripiprazoleDopamine D1 receptortarget
DB01238AripiprazoleDopamine D5 receptortarget
DB01238AripiprazoleDopamine D3 receptortarget
DB01238AripiprazoleDopamine D4 receptortarget
DB01238Aripiprazole5-hydroxytryptamine receptor 2Ctarget
DB01238Aripiprazole5-hydroxytryptamine receptor 3Atarget
DB01238Aripiprazole5-hydroxytryptamine receptor 6target
DB01238Aripiprazole5-hydroxytryptamine receptor 7target
DB01238AripiprazoleHistamine H1 receptortarget
DB01238AripiprazoleAlpha-1A adrenergic receptortarget
DB01238AripiprazoleAlpha-1B adrenergic receptortarget
DB01238AripiprazoleAlpha-2A adrenergic receptortarget
DB01238AripiprazoleAlpha-2B adrenergic receptortarget
DB01238AripiprazoleAlpha-2C adrenergic receptortarget
DB01238AripiprazoleMuscarinic acetylcholine receptor M1target
DB01238AripiprazoleMuscarinic acetylcholine receptor M2target
DB01238AripiprazoleMuscarinic acetylcholine receptor M3target
DB01238AripiprazoleMuscarinic acetylcholine receptor M4target
DB01238AripiprazoleMuscarinic acetylcholine receptor M5target
DB01238AripiprazoleCytochrome P450 3A5enzyme
DB01238AripiprazoleCytochrome P450 3A7enzyme
DB01238AripiprazoleSerum albumincarrier
DB00734RisperidoneHistamine H1 receptortarget
DB00734RisperidoneDopamine D2 receptortarget
DB00734RisperidoneAlpha-1A adrenergic receptortarget
DB00734Risperidone5-hydroxytryptamine receptor 2Atarget
DB00734RisperidoneAlpha-1B adrenergic receptortarget
DB00734RisperidoneCytochrome P450 2D6enzyme
DB00734RisperidoneDopamine D1 receptortarget
DB00734RisperidoneAlpha-2A adrenergic receptortarget
DB00734RisperidoneAlpha-2B adrenergic receptortarget
DB00734RisperidoneAlpha-2C adrenergic receptortarget
DB00734Risperidone5-hydroxytryptamine receptor 1Atarget
DB00734Risperidone5-hydroxytryptamine receptor 1Dtarget
DB00734Risperidone5-hydroxytryptamine receptor 2Ctarget
DB00734RisperidoneDopamine D3 receptortarget
DB00734RisperidoneDopamine D4 receptortarget
DB00734RisperidoneCytochrome P450 3A4enzyme
DB00734Risperidone5-hydroxytryptamine receptor 7target
DB00734RisperidoneP-glycoprotein 1transporter
DrugDrug NamePhaseStatusCount
DB00184Nicotine1Completed1
DB00996Gabapentin2Terminated1
DB08872Gabapentin enacarbil2Terminated1
DB00107Oxytocin2Not Yet Recruiting1
DB10276Rotavirus Vaccine2Completed1
DB10276Rotavirus Vaccine2 / 3Completed1
DB09128Brexpiprazole3Completed1
DB00514Dextromethorphan3Recruiting1
DB00908Quinidine3Recruiting1
DB00915AmantadineNot AvailableCompleted1
DB00151L-CysteineNot AvailableWithdrawn1