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Identification
NameQuinidine
Accession NumberDB00908  (APRD00136)
TypeSmall Molecule
GroupsApproved
DescriptionAn optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular action potential, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission. [PubChem]
Structure
Thumb
Synonyms
(+)-quinidine
(8R,9S)-Quinidine
(R)-(6-Methoxyquinolin-4-yl)((3S,4R,7S)-3-vinylquinuclidin-7-yl)methanol
(S)-(6-Methoxy-quinolin-4-yl)-((2R,5R)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol
(S)-(6-Methoxyquinolin-4-yl)((2R,5R)-5-vinylquinuclidin-2-yl)methanol
6-Methoxy-alpha-(5-vinyl-2-quinuclidinyl)-4-quinolinemethanol
alpha-(6-Methoxy-4-quinolyl)-5-vinyl-2-quinuclidinemethanol
beta-Quinine
Chinidin
Chinidinum
CIN-QUIN
Conchinin
Conquinine
Kinidin
Pitayine
Quinidina
Quinidine
β-quinine
External Identifiers Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Cardioquin TabletsTablet275 mgOralPurdue Pharma1961-12-312000-07-17Canada
Novo-quinidin 200mgTablet200 mgOralNovopharm Limited1966-12-312005-08-10Canada
Quinate Tab 325mgTablet325 mgOralRougier Pharma Division Of Ratiopharm Inc1979-12-312003-09-22Canada
Quinidex Extentabs Srt 300mgTablet, extended release300 mgOralAyerst Laboratories1991-12-311996-09-10Canada
Quinidex Extentabs Srt 300mgTablet, extended release300 mgOralWyeth Ayerst Canada Inc.1994-12-312001-10-29Canada
Quinidine 200 TabTablet200 mgOralPro Doc Limitee1982-12-312003-07-31Canada
Quinidine GluconateSolution80 mg/mLIntravenousEli Lilly and Company1951-03-01Not applicableUs
Quinidine Gluconate for Inj 80mg/ml USPLiquid80 mgIntramuscular; IntravenousEli Lilly Canada Inc1991-12-311997-08-13Canada
Quinidine Sulfate 200mgTablet200 mgOralRougier Pharma Division Of Ratiopharm Inc1970-12-311999-09-27Canada
Quinidine Sulfate Injection 190mg/mlSolution190 mgIntramuscularHospira Healthcare Corporation1981-12-31Not applicableCanada
Quinidine Sulfate Tab 200mgTablet200 mgOralGlaxo Wellcome Inc.1938-12-311999-08-24Canada
Quinidine Sulfate Tab 200mgTablet195 mgOralStanley Pharmaceuticals, A Division Of Vita Health Products Inc.1957-12-312001-07-20Canada
Approved Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Apo Quinidine Tab 200mgTablet200 mgOralApotex Inc1979-12-312010-01-19Canada
Apo-quin-G Tab 325mgTablet325 mgOralApotex Inc1985-12-312010-01-19Canada
Quinidine GluconateTablet, extended release324 mg/1OralCarilion Materials Management1987-02-10Not applicableUs
Quinidine GluconateTablet, extended release324 mg/1OralMutual Pharmaceutical Company, Inc.1987-02-10Not applicableUs
Quinidine GluconateTablet, extended release324 mg/1OralRichmond Pharmaceuticals, Inc.1987-02-10Not applicableUs
Quinidine SulfateTablet, film coated, extended release300 mg/1OralTeva Pharmaceuticals USA Inc1995-01-012016-03-31Us
Quinidine SulfateTablet200 mg/1OralWatson Laboratories, Inc.1976-11-24Not applicableUs
Quinidine SulfateTablet200 mg/1OralCarilion Materials Management1976-11-24Not applicableUs
Quinidine SulfateTablet300 mg/1OralWatson Laboratories, Inc.1981-06-09Not applicableUs
Quinidine SulfateTablet300 mg/1OralEon Labs, Inc.1983-09-26Not applicableUs
Quinidine SulfateTablet200 mg/1OralEon Labs, Inc.1976-11-24Not applicableUs
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
CardioquinNot Available
KinidinNot Available
Quin-ReleaseNot Available
QuinagluteNot Available
QuinalanNot Available
QuinicardineNot Available
QuinidexNot Available
Brand mixtures
NameLabellerIngredients
NuedextaAvanir Pharmaceuticals, Inc.
Salts
Name/CASStructureProperties
Quinidine gluconate
ThumbNot applicableDBSALT001251
Quinidine polygalacturonate
ThumbNot applicableDBSALT001344
Quinidine sulfate
Thumb
  • InChI Key: LOUPRKONTZGTKE-UYVJDWJCSA-N
  • Monoisotopic Mass: 324.183778022
  • Average Mass: 324.4168
DBSALT000363
Categories
UNIIITX08688JL
CAS number56-54-2
WeightAverage: 324.4168
Monoisotopic: 324.183778022
Chemical FormulaC20H24N2O2
InChI KeyLOUPRKONTZGTKE-LHHVKLHASA-N
InChI
InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19+,20-/m0/s1
IUPAC Name
(S)-[(2R,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl](6-methoxyquinolin-4-yl)methanol
SMILES
[H][C@@]12CCN(C[C@@H]1C=C)[C@]([H])(C2)[C@@H](O)C1=C2C=C(OC)C=CC2=NC=C1
Pharmacology
IndicationFor the treatment of ventricular pre-excitation and cardiac dysrhythmias
Structured Indications
PharmacodynamicsQuinidine, a hydantoin anticonvulsant, is used alone or with phenobarbital or other anticonvulsants to manage tonic-clonic seizures, psychomotor seizures, neuropathic pain syndromes including diabetic neuropathy, digitalis-induced cardiac arrhythmias, and cardiac arrhythmias associated with QT-interval prolongation.
Mechanism of actionQuinidine acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. The antiarrhythmic actions are mediated through effects on sodium channels in Purkinje fibers. Quinidine may also act on the slow inward calcium current (ICa), the rapid (IKr) and slow (IKs) components of the delayed potassium rectifier current, the inward potassium rectifier current (IKI), the ATP-sensitive potassium channel (IKATP) and Ito.
TargetKindPharmacological actionActionsOrganismUniProt ID
Sodium channel protein type 5 subunit alphaProteinyes
inhibitor
HumanQ14524 details
Potassium channel subfamily K member 1Proteinunknown
inhibitor
HumanO00180 details
Potassium channel subfamily K member 6Proteinunknown
inhibitor
HumanQ9Y257 details
Potassium voltage-gated channel subfamily H member 2Proteinunknown
inhibitor
HumanQ12809 details
Related Articles
AbsorptionNot Available
Volume of distribution
  • 2 to 3 L/kg
  • 0.5 L/kg [congestive heart failure]
  • 3 to 5 L/kg [cirrhosis of the liver]
Protein binding80-88%
Metabolism
SubstrateEnzymesProduct
Quinidine
3-HydroxyquinidineDetails
Route of eliminationWhen the urine pH is less than 7, about 20% of administered quinidine appears unchanged in the urine, but this fraction drops to as little as 5% when the urine is more alkaline.
Half life6-8 hours
Clearance
  • 3 – 5 mL/min/kg [adults]
ToxicityNot Available
Affected organisms
  • Humans and other mammals
Pathways
PathwayCategorySMPDB ID
Quinidine Action PathwayDrug actionSMP00323
SNP Mediated EffectsNot Available
SNP Mediated Adverse Drug ReactionsNot Available
Interactions
Drug Interactions
DrugInteractionDrug group
1,10-PhenanthrolineThe therapeutic efficacy of Quinidine can be decreased when used in combination with 1,10-Phenanthroline.Experimental
2-HYDROXY-1,4-NAPHTHOQUINONEThe metabolism of Quinidine can be decreased when combined with 2-HYDROXY-1,4-NAPHTHOQUINONE.Experimental
2-mercaptobenzothiazoleThe metabolism of Quinidine can be decreased when combined with 2-mercaptobenzothiazole.Vet Approved
4-MethoxyamphetamineThe metabolism of 4-Methoxyamphetamine can be decreased when combined with Quinidine.Experimental, Illicit
AbirateroneThe serum concentration of Quinidine can be increased when it is combined with Abiraterone.Approved
AcebutololThe serum concentration of Acebutolol can be increased when it is combined with Quinidine.Approved
AcenocoumarolQuinidine may increase the anticoagulant activities of Acenocoumarol.Approved
AcepromazineThe serum concentration of Acepromazine can be increased when it is combined with Quinidine.Approved, Vet Approved
AceprometazineThe serum concentration of Aceprometazine can be increased when it is combined with Quinidine.Approved
AcetaminophenThe metabolism of Acetaminophen can be decreased when combined with Quinidine.Approved
AcetazolamideAcetazolamide may decrease the excretion rate of Quinidine which could result in a higher serum level.Approved, Vet Approved
AcetylcholineThe metabolism of Acetylcholine can be decreased when combined with Quinidine.Approved
AcetyldigitoxinThe serum concentration of Acetyldigitoxin can be increased when it is combined with Quinidine.Approved
Acetylsalicylic acidThe serum concentration of Acetylsalicylic acid can be increased when it is combined with Quinidine.Approved, Vet Approved
AclidiniumAclidinium may increase the anticholinergic activities of Quinidine.Approved
AfatinibThe serum concentration of Afatinib can be increased when it is combined with Quinidine.Approved
AjmalineThe metabolism of Ajmaline can be decreased when combined with Quinidine.Approved
AlbendazoleThe serum concentration of Quinidine can be increased when it is combined with Albendazole.Approved, Vet Approved
AldosteroneThe serum concentration of Quinidine can be decreased when it is combined with Aldosterone.Experimental
AlectinibThe serum concentration of Quinidine can be increased when it is combined with Alectinib.Approved
AlfentanilThe serum concentration of Quinidine can be increased when it is combined with Alfentanil.Approved, Illicit
AlfuzosinAlfuzosin may increase the QTc-prolonging activities of Quinidine.Approved, Investigational
AlimemazineThe serum concentration of Alimemazine can be increased when it is combined with Quinidine.Approved, Vet Approved
AlitretinoinThe serum concentration of Alitretinoin can be increased when it is combined with Quinidine.Approved, Investigational
AlmotriptanThe metabolism of Almotriptan can be decreased when combined with Quinidine.Approved, Investigational
AlogliptinThe metabolism of Alogliptin can be decreased when combined with Quinidine.Approved
AlphacetylmethadolThe risk or severity of adverse effects can be increased when Quinidine is combined with Alphacetylmethadol.Experimental, Illicit
AlprenololThe metabolism of Alprenolol can be decreased when combined with Quinidine.Approved, Withdrawn
Aluminum hydroxideAluminum hydroxide may decrease the excretion rate of Quinidine which could result in a higher serum level.Approved
Aluminum phosphateAluminum phosphate may decrease the excretion rate of Quinidine which could result in a higher serum level.Approved
AmantadineAmantadine may increase the QTc-prolonging activities of Quinidine.Approved
AmbenoniumThe therapeutic efficacy of Quinidine can be decreased when used in combination with Ambenonium.Approved
AmbrisentanThe serum concentration of Ambrisentan can be increased when it is combined with Quinidine.Approved, Investigational
AmilorideThe therapeutic efficacy of Quinidine can be decreased when used in combination with Amiloride.Approved
AmineptineAmineptine may increase the QTc-prolonging activities of Quinidine.Illicit, Withdrawn
Aminohippuric acidThe serum concentration of Quinidine can be increased when it is combined with Aminohippuric acid.Approved
AminophenazoneThe metabolism of Aminophenazone can be decreased when combined with Quinidine.Approved, Withdrawn
AmiodaroneAmiodarone may increase the QTc-prolonging activities of Quinidine.Approved, Investigational
AmitriptylineAmitriptyline may increase the QTc-prolonging activities of Quinidine.Approved
AmlodipineThe serum concentration of Quinidine can be decreased when it is combined with Amlodipine.Approved
AmorolfineThe metabolism of Quinidine can be decreased when combined with Amorolfine.Approved
AmoxapineAmoxapine may increase the QTc-prolonging activities of Quinidine.Approved
AmphetamineThe metabolism of Amphetamine can be decreased when combined with Quinidine.Approved, Illicit
Amphotericin BThe metabolism of Quinidine can be decreased when combined with Amphotericin B.Approved, Investigational
AmprenavirThe metabolism of Amprenavir can be decreased when combined with Quinidine.Approved
AmsacrineThe metabolism of Amsacrine can be decreased when combined with Quinidine.Approved
AN2690The metabolism of Quinidine can be decreased when combined with AN2690.Investigational
AnagrelideAnagrelide may increase the QTc-prolonging activities of Quinidine.Approved
AnidulafunginThe metabolism of Quinidine can be decreased when combined with Anidulafungin.Approved, Investigational
Anisotropine MethylbromideThe risk or severity of adverse effects can be increased when Anisotropine Methylbromide is combined with Quinidine.Approved
AntipyrineThe metabolism of Antipyrine can be decreased when combined with Quinidine.Approved
AnvirzelThe serum concentration of Anvirzel can be increased when it is combined with Quinidine.Investigational
ApixabanThe serum concentration of Apixaban can be increased when it is combined with Quinidine.Approved
ApomorphineApomorphine may increase the QTc-prolonging activities of Quinidine.Approved, Investigational
AprepitantThe serum concentration of Quinidine can be increased when it is combined with Aprepitant.Approved, Investigational
AprindineThe metabolism of Aprindine can be decreased when combined with Quinidine.Approved
ArformoterolArformoterol may increase the QTc-prolonging activities of Quinidine.Approved, Investigational
AripiprazoleThe serum concentration of Aripiprazole can be increased when it is combined with Quinidine.Approved, Investigational
Arsenic trioxideQuinidine may increase the QTc-prolonging activities of Arsenic trioxide.Approved, Investigational
ArtemetherThe metabolism of Quinidine can be decreased when combined with Artemether.Approved
AsenapineQuinidine may increase the QTc-prolonging activities of Asenapine.Approved
AstemizoleThe metabolism of Astemizole can be decreased when combined with Quinidine.Approved, Withdrawn
AtazanavirThe serum concentration of Quinidine can be increased when it is combined with Atazanavir.Approved, Investigational
AtenololThe serum concentration of Atenolol can be increased when it is combined with Quinidine.Approved
AtomoxetineThe serum concentration of Atomoxetine can be increased when it is combined with Quinidine.Approved
AtorvastatinThe serum concentration of Quinidine can be increased when it is combined with Atorvastatin.Approved
Atracurium besylateQuinidine may increase the neuromuscular blocking activities of Atracurium besylate.Approved
AtropineThe risk or severity of adverse effects can be increased when Atropine is combined with Quinidine.Approved, Vet Approved
AxitinibThe serum concentration of Axitinib can be increased when it is combined with Quinidine.Approved, Investigational
AzelastineThe metabolism of Azelastine can be decreased when combined with Quinidine.Approved
AzithromycinAzithromycin may increase the QTc-prolonging activities of Quinidine.Approved
Bafilomycin A1The metabolism of Quinidine can be decreased when combined with Bafilomycin A1.Experimental
BedaquilineBedaquiline may increase the QTc-prolonging activities of Quinidine.Approved
BenactyzineThe risk or severity of adverse effects can be increased when Quinidine is combined with Benactyzine.Withdrawn
BendroflumethiazideThe serum concentration of Bendroflumethiazide can be increased when it is combined with Quinidine.Approved
BenzatropineThe metabolism of Benzatropine can be decreased when combined with Quinidine.Approved
BenzocaineThe serum concentration of Quinidine can be increased when it is combined with Benzocaine.Approved
Benzoic AcidThe metabolism of Quinidine can be decreased when combined with Benzoic Acid.Approved
Benzyl alcoholThe metabolism of Benzyl alcohol can be decreased when combined with Quinidine.Approved
BepridilThe metabolism of Bepridil can be decreased when combined with Quinidine.Approved, Withdrawn
BetamethasoneThe serum concentration of Betamethasone can be increased when it is combined with Quinidine.Approved, Vet Approved
BetaxololThe metabolism of Betaxolol can be decreased when combined with Quinidine.Approved
BexaroteneThe serum concentration of Quinidine can be decreased when it is combined with Bexarotene.Approved, Investigational
BezitramideThe risk or severity of adverse effects can be increased when Quinidine is combined with Bezitramide.Experimental, Illicit, Withdrawn
BifonazoleThe metabolism of Quinidine can be decreased when combined with Bifonazole.Approved
BiperidenThe risk or severity of adverse effects can be increased when Biperiden is combined with Quinidine.Approved
Bismuth SubcitrateBismuth Subcitrate may decrease the excretion rate of Quinidine which could result in a higher serum level.Approved
BisoprololThe metabolism of Bisoprolol can be decreased when combined with Quinidine.Approved
BL-1020The serum concentration of BL-1020 can be increased when it is combined with Quinidine.Investigational
BoceprevirThe serum concentration of Quinidine can be increased when it is combined with Boceprevir.Approved
BortezomibBortezomib may increase the QTc-prolonging activities of Quinidine.Approved, Investigational
BosentanThe serum concentration of Quinidine can be decreased when it is combined with Bosentan.Approved, Investigational
BosutinibThe serum concentration of Bosutinib can be increased when it is combined with Quinidine.Approved
Botulinum Toxin Type AQuinidine may increase the anticholinergic activities of Botulinum Toxin Type A.Approved, Investigational
Botulinum Toxin Type BQuinidine may increase the anticholinergic activities of Botulinum Toxin Type B.Approved
Brentuximab vedotinThe serum concentration of Brentuximab vedotin can be increased when it is combined with Quinidine.Approved
BrexpiprazoleThe serum concentration of Brexpiprazole can be increased when it is combined with Quinidine.Approved
BrinzolamideBrinzolamide may decrease the excretion rate of Quinidine which could result in a higher serum level.Approved
BromocriptineThe serum concentration of Bromocriptine can be increased when it is combined with Quinidine.Approved, Investigational
BrompheniramineThe metabolism of Brompheniramine can be decreased when combined with Quinidine.Approved
BufuralolThe metabolism of Bufuralol can be decreased when combined with Quinidine.Experimental, Investigational
BupivacaineThe metabolism of Bupivacaine can be decreased when combined with Quinidine.Approved, Investigational
BuprenorphineThe metabolism of Buprenorphine can be decreased when combined with Quinidine.Approved, Illicit, Investigational, Vet Approved
BupropionThe metabolism of Bupropion can be decreased when combined with Quinidine.Approved
BuserelinBuserelin may increase the QTc-prolonging activities of Quinidine.Approved
BuspironeThe metabolism of Buspirone can be decreased when combined with Quinidine.Approved, Investigational
ButenafineThe metabolism of Quinidine can be decreased when combined with Butenafine.Approved
ButoconazoleThe metabolism of Quinidine can be decreased when combined with Butoconazole.Approved
ButorphanolThe risk or severity of adverse effects can be increased when Quinidine is combined with Butorphanol.Approved, Illicit, Vet Approved
CabazitaxelThe serum concentration of Cabazitaxel can be increased when it is combined with Quinidine.Approved
CaffeineThe metabolism of Caffeine can be decreased when combined with Quinidine.Approved
Calcium carbonateCalcium carbonate may decrease the excretion rate of Quinidine which could result in a higher serum level.Approved
CamptothecinThe serum concentration of Camptothecin can be increased when it is combined with Quinidine.Experimental
CanagliflozinThe serum concentration of Canagliflozin can be increased when it is combined with Quinidine.Approved
CandesartanThe serum concentration of Quinidine can be increased when it is combined with Candesartan.Approved
CandicidinThe metabolism of Quinidine can be decreased when combined with Candicidin.Withdrawn
CapecitabineThe metabolism of Quinidine can be decreased when combined with Capecitabine.Approved, Investigational
CaptoprilThe metabolism of Captopril can be decreased when combined with Quinidine.Approved
CarbamazepineThe metabolism of Quinidine can be increased when combined with Carbamazepine.Approved, Investigational
CarfentanilThe risk or severity of adverse effects can be increased when Quinidine is combined with Carfentanil.Illicit, Vet Approved
CarfilzomibThe serum concentration of Carfilzomib can be increased when it is combined with Quinidine.Approved
CariprazineThe metabolism of Cariprazine can be decreased when combined with Quinidine.Approved
CarteololThe metabolism of Carteolol can be decreased when combined with Quinidine.Approved
CarvedilolThe metabolism of Carvedilol can be decreased when combined with Quinidine.Approved, Investigational
CaspofunginThe metabolism of Quinidine can be decreased when combined with Caspofungin.Approved
CelecoxibThe metabolism of Quinidine can be decreased when combined with Celecoxib.Approved, Investigational
CephalexinThe metabolism of Cephalexin can be decreased when combined with Quinidine.Approved, Vet Approved
CeritinibThe serum concentration of Quinidine can be increased when it is combined with Ceritinib.Approved
CerivastatinThe serum concentration of Cerivastatin can be increased when it is combined with Quinidine.Withdrawn
CeruleninThe metabolism of Quinidine can be decreased when combined with Cerulenin.Approved
CevimelineThe metabolism of Cevimeline can be decreased when combined with Quinidine.Approved
ChlordiazepoxideThe metabolism of Chlordiazepoxide can be decreased when combined with Quinidine.Approved, Illicit
ChloroquineChloroquine may increase the QTc-prolonging activities of Quinidine.Approved, Vet Approved
ChlorothiazideThe serum concentration of Chlorothiazide can be increased when it is combined with Quinidine.Approved, Vet Approved
ChloroxineThe metabolism of Quinidine can be decreased when combined with Chloroxine.Approved
ChlorphenamineThe metabolism of Chlorphenamine can be decreased when combined with Quinidine.Approved
ChlorphenoxamineThe risk or severity of adverse effects can be increased when Quinidine is combined with Chlorphenoxamine.Withdrawn
ChlorpromazineChlorpromazine may increase the QTc-prolonging activities of Quinidine.Approved, Vet Approved
ChlorpropamideThe serum concentration of Quinidine can be increased when it is combined with Chlorpropamide.Approved
ChlorprothixeneThe serum concentration of Quinidine can be increased when it is combined with Chlorprothixene.Approved, Withdrawn
ChlorthalidoneThe serum concentration of Chlorthalidone can be increased when it is combined with Quinidine.Approved
ChlorzoxazoneThe metabolism of Chlorzoxazone can be decreased when combined with Quinidine.Approved
CholecalciferolThe metabolism of Quinidine can be decreased when combined with Cholecalciferol.Approved, Nutraceutical
CholesterolThe serum concentration of Quinidine can be increased when it is combined with Cholesterol.Experimental
Cholic AcidQuinidine may decrease the excretion rate of Cholic Acid which could result in a higher serum level.Approved
CiclopiroxThe metabolism of Quinidine can be decreased when combined with Ciclopirox.Approved, Investigational
CilazaprilThe serum concentration of Quinidine can be increased when it is combined with Cilazapril.Approved
CilostazolThe metabolism of Cilostazol can be decreased when combined with Quinidine.Approved
CimetidineThe serum concentration of Quinidine can be increased when it is combined with Cimetidine.Approved
CimetropiumQuinidine may increase the anticholinergic activities of Cimetropium.Experimental
CinnarizineThe metabolism of Cinnarizine can be decreased when combined with Quinidine.Approved
CiprofloxacinCiprofloxacin may increase the QTc-prolonging activities of Quinidine.Approved, Investigational
CisaprideCisapride may increase the QTc-prolonging activities of Quinidine.Approved, Investigational, Withdrawn
Cisatracurium besylateQuinidine may increase the neuromuscular blocking activities of Cisatracurium besylate.Approved
CisplatinThe serum concentration of Cisplatin can be increased when it is combined with Quinidine.Approved
CitalopramCitalopram may increase the QTc-prolonging activities of Quinidine.Approved
ClarithromycinClarithromycin may increase the QTc-prolonging activities of Quinidine.Approved
ClemastineThe metabolism of Quinidine can be decreased when combined with Clemastine.Approved
ClevidipineThe serum concentration of Quinidine can be decreased when it is combined with Clevidipine.Approved
ClobazamThe serum concentration of Clobazam can be increased when it is combined with Quinidine.Approved, Illicit
ClofazimineThe serum concentration of Quinidine can be increased when it is combined with Clofazimine.Approved, Investigational
ClomifeneThe serum concentration of Clomifene can be increased when it is combined with Quinidine.Approved, Investigational
ClomipramineClomipramine may increase the QTc-prolonging activities of Quinidine.Approved, Vet Approved
ClonidineThe metabolism of Clonidine can be decreased when combined with Quinidine.Approved
ClopidogrelThe metabolism of Quinidine can be decreased when combined with Clopidogrel.Approved, Nutraceutical
ClotrimazoleThe metabolism of Quinidine can be decreased when combined with Clotrimazole.Approved, Vet Approved
ClozapineClozapine may increase the QTc-prolonging activities of Quinidine.Approved
CobicistatThe serum concentration of Quinidine can be increased when it is combined with Cobicistat.Approved
CobimetinibThe serum concentration of Cobimetinib can be increased when it is combined with Quinidine.Approved
CodeineThe therapeutic efficacy of Codeine can be decreased when used in combination with Quinidine.Approved, Illicit
ColchicineThe serum concentration of Colchicine can be increased when it is combined with Quinidine.Approved
ColforsinThe serum concentration of Quinidine can be increased when it is combined with Colforsin.Experimental
ConivaptanThe serum concentration of Quinidine can be increased when it is combined with Conivaptan.Approved, Investigational
Conjugated Equine EstrogensThe serum concentration of Conjugated Equine Estrogens can be increased when it is combined with Quinidine.Approved
CordycepinThe metabolism of Quinidine can be decreased when combined with Cordycepin.Investigational
CoumaphosThe therapeutic efficacy of Quinidine can be decreased when used in combination with Coumaphos.Vet Approved
CrizotinibCrizotinib may increase the QTc-prolonging activities of Quinidine.Approved
CyclobenzaprineCyclobenzaprine may increase the QTc-prolonging activities of Quinidine.Approved
CyclopentolateThe risk or severity of adverse effects can be increased when Quinidine is combined with Cyclopentolate.Approved
CyclophosphamideThe metabolism of Cyclophosphamide can be decreased when combined with Quinidine.Approved, Investigational
CyclosporineThe metabolism of Quinidine can be decreased when combined with Cyclosporine.Approved, Investigational, Vet Approved
Cyproterone acetateThe serum concentration of Quinidine can be decreased when it is combined with Cyproterone acetate.Approved, Investigational
Dabigatran etexilateThe serum concentration of Dabigatran etexilate can be increased when it is combined with Quinidine.Approved
DabrafenibThe serum concentration of Quinidine can be decreased when it is combined with Dabrafenib.Approved
DaclatasvirThe serum concentration of Quinidine can be increased when it is combined with Daclatasvir.Approved
DactinomycinThe serum concentration of Dactinomycin can be increased when it is combined with Quinidine.Approved
DalfampridineThe serum concentration of Dalfampridine can be increased when it is combined with Quinidine.Approved
DapagliflozinThe metabolism of Dapagliflozin can be decreased when combined with Quinidine.Approved
DapsoneThe risk or severity of adverse effects can be increased when Quinidine is combined with Dapsone.Approved, Investigational
DarifenacinThe metabolism of Darifenacin can be decreased when combined with Quinidine.Approved, Investigational
DarunavirThe serum concentration of Quinidine can be increased when it is combined with Darunavir.Approved
DasabuvirThe serum concentration of Quinidine can be increased when it is combined with Dasabuvir.Approved
DasatinibThe serum concentration of Quinidine can be increased when it is combined with Dasatinib.Approved, Investigational
DaunorubicinThe serum concentration of Quinidine can be decreased when it is combined with Daunorubicin.Approved
DebrisoquinThe metabolism of Debrisoquin can be decreased when combined with Quinidine.Approved
DecamethoniumQuinidine may increase the neuromuscular blocking activities of Decamethonium.Approved
Decanoic AcidThe metabolism of Quinidine can be decreased when combined with Decanoic Acid.Experimental
DeferasiroxThe serum concentration of Quinidine can be decreased when it is combined with Deferasirox.Approved, Investigational
DegarelixDegarelix may increase the QTc-prolonging activities of Quinidine.Approved
DelavirdineThe metabolism of Delavirdine can be decreased when combined with Quinidine.Approved
DemecariumThe therapeutic efficacy of Quinidine can be decreased when used in combination with Demecarium.Approved
DesfluraneDesflurane may increase the QTc-prolonging activities of Quinidine.Approved
DesipramineDesipramine may increase the QTc-prolonging activities of Quinidine.Approved
DeslanosideThe serum concentration of Deslanoside can be increased when it is combined with Quinidine.Approved
DesloratadineThe risk or severity of adverse effects can be increased when Quinidine is combined with Desloratadine.Approved, Investigational
DexamethasoneThe serum concentration of Quinidine can be decreased when it is combined with Dexamethasone.Approved, Investigational, Vet Approved
DexetimideThe risk or severity of adverse effects can be increased when Quinidine is combined with Dexetimide.Withdrawn
DexfenfluramineThe metabolism of Dexfenfluramine can be decreased when combined with Quinidine.Approved, Illicit, Withdrawn
DexmethylphenidateThe metabolism of Dexmethylphenidate can be decreased when combined with Quinidine.Approved
DextroamphetamineThe metabolism of Dextroamphetamine can be decreased when combined with Quinidine.Approved, Illicit
DextromethorphanThe serum concentration of Dextromethorphan can be increased when it is combined with Quinidine.Approved
DextromoramideThe risk or severity of adverse effects can be increased when Quinidine is combined with Dextromoramide.Experimental, Illicit
DextropropoxypheneThe risk or severity of adverse effects can be increased when Quinidine is combined with Dextropropoxyphene.Approved, Illicit, Withdrawn
DezocineThe risk or severity of adverse effects can be increased when Quinidine is combined with Dezocine.Approved
DiazepamThe serum concentration of Diazepam can be increased when it is combined with Quinidine.Approved, Illicit, Vet Approved
DichlorvosThe therapeutic efficacy of Quinidine can be decreased when used in combination with Dichlorvos.Vet Approved
DiclofenacThe serum concentration of Quinidine can be increased when it is combined with Diclofenac.Approved, Vet Approved
DiclofenamideDiclofenamide may decrease the excretion rate of Quinidine which could result in a higher serum level.Approved
DicoumarolQuinidine may increase the anticoagulant activities of Dicoumarol.Approved
DicyclomineThe risk or severity of adverse effects can be increased when Dicyclomine is combined with Quinidine.Approved
DiethylstilbestrolThe serum concentration of Diethylstilbestrol can be increased when it is combined with Quinidine.Approved
DigitoxinThe serum concentration of Digitoxin can be increased when it is combined with Quinidine.Approved
DigoxinThe serum concentration of Digoxin can be increased when it is combined with Quinidine.Approved
DihydrocodeineQuinidine may decrease the analgesic activities of Dihydrocodeine.Approved, Illicit
DihydroergotamineThe metabolism of Quinidine can be decreased when combined with Dihydroergotamine.Approved
DihydroetorphineThe risk or severity of adverse effects can be increased when Quinidine is combined with Dihydroetorphine.Experimental, Illicit
DihydromorphineThe risk or severity of adverse effects can be increased when Quinidine is combined with Dihydromorphine.Experimental, Illicit
DihydrotestosteroneThe serum concentration of Dihydrotestosterone can be increased when it is combined with Quinidine.Illicit
DiltiazemThe serum concentration of Quinidine can be increased when it is combined with Diltiazem.Approved
DiphenhydramineDiphenhydramine may increase the QTc-prolonging activities of Quinidine.Approved
DiphenoxylateThe risk or severity of adverse effects can be increased when Quinidine is combined with Diphenoxylate.Approved, Illicit
DipyridamoleThe serum concentration of Dipyridamole can be increased when it is combined with Quinidine.Approved
DisopyramideDisopyramide may increase the QTc-prolonging activities of Quinidine.Approved
DisulfiramThe metabolism of Quinidine can be decreased when combined with Disulfiram.Approved
DocetaxelThe serum concentration of Docetaxel can be increased when it is combined with Quinidine.Approved, Investigational
DofetilideThe serum concentration of Dofetilide can be increased when it is combined with Quinidine.Approved
DolasetronDolasetron may increase the QTc-prolonging activities of Quinidine.Approved
Domoic AcidQuinidine may increase the neuromuscular blocking activities of Domoic Acid.Experimental
DomperidoneQuinidine may increase the QTc-prolonging activities of Domperidone.Approved, Investigational, Vet Approved
DonepezilThe metabolism of Donepezil can be decreased when combined with Quinidine.Approved
DopamineThe metabolism of Dopamine can be decreased when combined with Quinidine.Approved
DorzolamideDorzolamide may decrease the excretion rate of Quinidine which could result in a higher serum level.Approved
DosulepinDosulepin may increase the QTc-prolonging activities of Quinidine.Approved
Doxacurium chlorideQuinidine may increase the neuromuscular blocking activities of Doxacurium chloride.Approved
DoxazosinThe metabolism of Doxazosin can be decreased when combined with Quinidine.Approved
DoxepinDoxepin may increase the QTc-prolonging activities of Quinidine.Approved
DoxorubicinThe serum concentration of Doxorubicin can be increased when it is combined with Quinidine.Approved, Investigational
DoxorubicinThe metabolism of Doxorubicin can be decreased when combined with Quinidine.Approved, Investigational
DoxycyclineThe metabolism of Quinidine can be decreased when combined with Doxycycline.Approved, Investigational, Vet Approved
DPDPEThe risk or severity of adverse effects can be increased when Quinidine is combined with DPDPE.Investigational
DronabinolQuinidine may increase the tachycardic activities of Dronabinol.Approved, Illicit
DronedaroneQuinidine may increase the QTc-prolonging activities of Dronedarone.Approved
DroperidolDroperidol may increase the QTc-prolonging activities of Quinidine.Approved, Vet Approved
DuloxetineThe serum concentration of Duloxetine can be increased when it is combined with Quinidine.Approved
EchothiophateThe therapeutic efficacy of Quinidine can be decreased when used in combination with Echothiophate.Approved
EconazoleThe metabolism of Quinidine can be decreased when combined with Econazole.Approved
EdoxabanThe serum concentration of Edoxaban can be increased when it is combined with Quinidine.Approved
EdrophoniumThe therapeutic efficacy of Quinidine can be decreased when used in combination with Edrophonium.Approved
EfavirenzThe serum concentration of Quinidine can be decreased when it is combined with Efavirenz.Approved, Investigational
EfinaconazoleThe metabolism of Quinidine can be decreased when combined with Efinaconazole.Approved
ElbasvirThe serum concentration of Quinidine can be increased when it is combined with Elbasvir.Approved
EletriptanThe metabolism of Eletriptan can be decreased when combined with Quinidine.Approved, Investigational
EliglustatThe serum concentration of Eliglustat can be increased when it is combined with Quinidine.Approved
EluxadolineQuinidine may increase the constipating activities of Eluxadoline.Approved
EnalaprilThe serum concentration of Quinidine can be increased when it is combined with Enalapril.Approved, Vet Approved
EncainideThe metabolism of Encainide can be decreased when combined with Quinidine.Approved, Withdrawn
EnclomipheneThe metabolism of Enclomiphene can be decreased when combined with Quinidine.Investigational
EnzalutamideThe serum concentration of Quinidine can be decreased when it is combined with Enzalutamide.Approved
EpinastineThe metabolism of Epinastine can be decreased when combined with Quinidine.Approved, Investigational
EplerenoneThe therapeutic efficacy of Quinidine can be decreased when used in combination with Eplerenone.Approved
ErgonovineThe serum concentration of Quinidine can be increased when it is combined with Ergonovine.Approved
ErgotamineThe serum concentration of Quinidine can be increased when it is combined with Ergotamine.Approved
EribulinEribulin may increase the QTc-prolonging activities of Quinidine.Approved, Investigational
ErlotinibThe metabolism of Erlotinib can be decreased when combined with Quinidine.Approved, Investigational
ErythromycinErythromycin may increase the QTc-prolonging activities of Quinidine.Approved, Vet Approved
EscitalopramQuinidine may increase the QTc-prolonging activities of Escitalopram.Approved, Investigational
Eslicarbazepine acetateThe serum concentration of Quinidine can be decreased when it is combined with Eslicarbazepine acetate.Approved
EsmirtazapineEsmirtazapine may increase the QTc-prolonging activities of Quinidine.Investigational
EstradiolThe serum concentration of Estradiol can be increased when it is combined with Quinidine.Approved, Investigational, Vet Approved
EstramustineThe serum concentration of Quinidine can be increased when it is combined with Estramustine.Approved
EstriolThe serum concentration of Quinidine can be decreased when it is combined with Estriol.Approved, Vet Approved
EstroneThe serum concentration of Quinidine can be decreased when it is combined with Estrone.Approved
Ethinyl EstradiolThe serum concentration of Ethinyl Estradiol can be increased when it is combined with Quinidine.Approved
EthopropazineThe risk or severity of adverse effects can be increased when Ethopropazine is combined with Quinidine.Approved
EthoxzolamideEthoxzolamide may decrease the excretion rate of Quinidine which could result in a higher serum level.Withdrawn
Ethyl biscoumacetateQuinidine may increase the anticoagulant activities of Ethyl biscoumacetate.Withdrawn
EthylmorphineThe metabolism of Ethylmorphine can be decreased when combined with Quinidine.Approved, Illicit
EtoposideThe serum concentration of Etoposide can be increased when it is combined with Quinidine.Approved
EtoricoxibThe metabolism of Etoricoxib can be decreased when combined with Quinidine.Approved, Investigational
EtorphineThe risk or severity of adverse effects can be increased when Quinidine is combined with Etorphine.Illicit, Vet Approved
EtravirineThe serum concentration of Quinidine can be decreased when it is combined with Etravirine.Approved
EverolimusThe serum concentration of Everolimus can be increased when it is combined with Quinidine.Approved
EzetimibeThe serum concentration of Ezetimibe can be increased when it is combined with Quinidine.Approved
EzogabineEzogabine may increase the QTc-prolonging activities of Quinidine.Approved
FamotidineFamotidine may increase the QTc-prolonging activities of Quinidine.Approved
FelbamateFelbamate may increase the QTc-prolonging activities of Quinidine.Approved
FelodipineThe serum concentration of Quinidine can be decreased when it is combined with Felodipine.Approved, Investigational
FentanylThe serum concentration of Quinidine can be increased when it is combined with Fentanyl.Approved, Illicit, Investigational, Vet Approved
FenthionThe therapeutic efficacy of Quinidine can be decreased when used in combination with Fenthion.Vet Approved
FesoterodineThe serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Quinidine.Approved
FexofenadineThe serum concentration of Fexofenadine can be increased when it is combined with Quinidine.Approved
FidaxomicinThe serum concentration of Fidaxomicin can be increased when it is combined with Quinidine.Approved
FingolimodFingolimod may increase the arrhythmogenic activities of Quinidine.Approved, Investigational
FlecainideFlecainide may increase the QTc-prolonging activities of Quinidine.Approved, Withdrawn
FlibanserinThe serum concentration of Flibanserin can be increased when it is combined with Quinidine.Approved
FloxuridineThe metabolism of Quinidine can be decreased when combined with Floxuridine.Approved
FluconazoleThe metabolism of Quinidine can be decreased when combined with Fluconazole.Approved
FlucytosineThe metabolism of Quinidine can be decreased when combined with Flucytosine.Approved
FluindioneQuinidine may increase the anticoagulant activities of Fluindione.Investigational
FlunarizineThe metabolism of Flunarizine can be decreased when combined with Quinidine.Approved
FluorouracilThe metabolism of Quinidine can be decreased when combined with Fluorouracil.Approved
FluoxetineFluoxetine may increase the QTc-prolonging activities of Quinidine.Approved, Vet Approved
FlupentixolFlupentixol may increase the QTc-prolonging activities of Quinidine.Approved, Withdrawn
FluphenazineThe metabolism of Fluphenazine can be decreased when combined with Quinidine.Approved
FlurazepamThe serum concentration of Quinidine can be increased when it is combined with Flurazepam.Approved, Illicit
Fluticasone furoateThe serum concentration of Fluticasone furoate can be increased when it is combined with Quinidine.Approved
FluvastatinThe metabolism of Fluvastatin can be decreased when combined with Quinidine.Approved
FluvoxamineThe serum concentration of Quinidine can be increased when it is combined with Fluvoxamine.Approved, Investigational
FormoterolFormoterol may increase the QTc-prolonging activities of Quinidine.Approved, Investigational
FosamprenavirThe serum concentration of Quinidine can be increased when it is combined with Fosamprenavir.Approved
FosaprepitantThe serum concentration of Quinidine can be increased when it is combined with Fosaprepitant.Approved
FoscarnetFoscarnet may increase the QTc-prolonging activities of Quinidine.Approved
FosphenytoinFosphenytoin may increase the QTc-prolonging activities of Quinidine.Approved
Fusidic AcidThe serum concentration of Quinidine can be increased when it is combined with Fusidic Acid.Approved
Gadobenic acidGadobenic acid may increase the QTc-prolonging activities of Quinidine.Approved
GalantamineGalantamine may increase the QTc-prolonging activities of Quinidine.Approved
Gallamine TriethiodideQuinidine may increase the neuromuscular blocking activities of Gallamine Triethiodide.Approved
GefitinibThe metabolism of Gefitinib can be decreased when combined with Quinidine.Approved, Investigational
GemcitabineThe serum concentration of Gemcitabine can be increased when it is combined with Quinidine.Approved
GemfibrozilThe metabolism of Quinidine can be decreased when combined with Gemfibrozil.Approved
GemifloxacinGemifloxacin may increase the QTc-prolonging activities of Quinidine.Approved, Investigational
GenisteinThe serum concentration of Quinidine can be increased when it is combined with Genistein.Investigational
Ginkgo bilobaThe therapeutic efficacy of Quinidine can be decreased when used in combination with Ginkgo biloba.Approved, Nutraceutical
Glucagon recombinantThe risk or severity of adverse effects can be increased when Quinidine is combined with Glucagon recombinant.Approved
GlyburideThe serum concentration of Quinidine can be increased when it is combined with Glyburide.Approved
GlycerolThe serum concentration of Quinidine can be increased when it is combined with Glycerol.Experimental
GlycopyrroniumQuinidine may increase the anticholinergic activities of Glycopyrronium.Approved, Investigational, Vet Approved
GlyphosateThe metabolism of Quinidine can be decreased when combined with Glyphosate.Experimental
GoserelinGoserelin may increase the QTc-prolonging activities of Quinidine.Approved
Gramicidin DThe serum concentration of Quinidine can be increased when it is combined with Gramicidin D.Approved
GranisetronGranisetron may increase the QTc-prolonging activities of Quinidine.Approved, Investigational
GrazoprevirThe serum concentration of Grazoprevir can be increased when it is combined with Quinidine.Approved
GrepafloxacinThe serum concentration of Grepafloxacin can be increased when it is combined with Quinidine.Withdrawn
GriseofulvinThe metabolism of Quinidine can be decreased when combined with Griseofulvin.Approved, Vet Approved
HalofantrineThe metabolism of Halofantrine can be decreased when combined with Quinidine.Approved
HaloperidolHaloperidol may increase the QTc-prolonging activities of Quinidine.Approved
HaloproginThe metabolism of Quinidine can be decreased when combined with Haloprogin.Approved, Withdrawn
HalothaneThe metabolism of Halothane can be decreased when combined with Quinidine.Approved, Vet Approved
HeroinThe risk or severity of adverse effects can be increased when Quinidine is combined with Heroin.Approved, Illicit
HexamethoniumThe risk or severity of adverse effects can be increased when Quinidine is combined with Hexamethonium.Experimental
HexetidineThe metabolism of Quinidine can be decreased when combined with Hexetidine.Approved
HistrelinHistrelin may increase the QTc-prolonging activities of Quinidine.Approved
HomatropineThe risk or severity of adverse effects can be increased when Quinidine is combined with Homatropine.Approved
Huperzine AThe therapeutic efficacy of Quinidine can be decreased when used in combination with Huperzine A.Investigational
HydrochlorothiazideThe serum concentration of Hydrochlorothiazide can be increased when it is combined with Quinidine.Approved, Vet Approved
HydrocodoneThe serum concentration of the active metabolites of Hydrocodone can be reduced when Hydrocodone is used in combination with Quinidine resulting in a loss in efficacy.Approved, Illicit
HydrocortisoneThe serum concentration of Hydrocortisone can be increased when it is combined with Quinidine.Approved, Vet Approved
HydroflumethiazideThe serum concentration of Hydroflumethiazide can be increased when it is combined with Quinidine.Approved
HydromorphoneThe metabolism of Hydromorphone can be decreased when combined with Quinidine.Approved, Illicit
HydroxyzineHydroxyzine may increase the QTc-prolonging activities of Quinidine.Approved
HyoscyamineThe risk or severity of adverse effects can be increased when Hyoscyamine is combined with Quinidine.Approved
IbandronateIbandronate may increase the QTc-prolonging activities of Quinidine.Approved, Investigational
IbrutinibThe metabolism of Ibrutinib can be decreased when combined with Quinidine.Approved
IbuprofenThe serum concentration of Ibuprofen can be increased when it is combined with Quinidine.Approved
IbutilideIbutilide may increase the QTc-prolonging activities of Quinidine.Approved
IdarubicinThe metabolism of Idarubicin can be decreased when combined with Quinidine.Approved
IdelalisibThe serum concentration of Quinidine can be increased when it is combined with Idelalisib.Approved
IloperidoneThe serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with Quinidine.Approved
ImatinibThe metabolism of Imatinib can be decreased when combined with Quinidine.Approved
ImipramineImipramine may increase the QTc-prolonging activities of Quinidine.Approved
IndacaterolIndacaterol may increase the QTc-prolonging activities of Quinidine.Approved
IndapamideIndapamide may increase the QTc-prolonging activities of Quinidine.Approved
IndinavirThe serum concentration of Quinidine can be increased when it is combined with Indinavir.Approved
IndomethacinThe serum concentration of Indomethacin can be increased when it is combined with Quinidine.Approved, Investigational
Ipratropium bromideThe metabolism of Ipratropium bromide can be decreased when combined with Quinidine.Approved
IrbesartanThe metabolism of Quinidine can be decreased when combined with Irbesartan.Approved, Investigational
IrinotecanThe serum concentration of Irinotecan can be increased when it is combined with Quinidine.Approved, Investigational
IsavuconazoniumThe metabolism of Quinidine can be decreased when combined with Isavuconazonium.Approved, Investigational
IsoconazoleThe metabolism of Quinidine can be decreased when combined with Isoconazole.Approved
IsofluraneIsoflurane may increase the QTc-prolonging activities of Quinidine.Approved, Vet Approved
IsoflurophateThe therapeutic efficacy of Quinidine can be decreased when used in combination with Isoflurophate.Approved, Withdrawn
IsoniazidThe metabolism of Quinidine can be decreased when combined with Isoniazid.Approved
IsradipineThe serum concentration of Quinidine can be decreased when it is combined with Isradipine.Approved
ItoprideThe therapeutic efficacy of Itopride can be decreased when used in combination with Quinidine.Investigational
ItraconazoleThe metabolism of Quinidine can be decreased when combined with Itraconazole.Approved, Investigational
IvabradineIvabradine may increase the QTc-prolonging activities of Quinidine.Approved
IvacaftorThe serum concentration of Quinidine can be increased when it is combined with Ivacaftor.Approved
IvermectinThe serum concentration of Ivermectin can be increased when it is combined with Quinidine.Approved, Vet Approved
IxazomibThe metabolism of Ixazomib can be decreased when combined with Quinidine.Approved
KaolinThe serum concentration of Quinidine can be decreased when it is combined with Kaolin.Approved
KetamineThe serum concentration of Quinidine can be increased when it is combined with Ketamine.Approved, Vet Approved
KetazolamThe serum concentration of Ketazolam can be increased when it is combined with Quinidine.Approved
KetobemidoneThe risk or severity of adverse effects can be increased when Quinidine is combined with Ketobemidone.Approved
KetoconazoleThe metabolism of Quinidine can be decreased when combined with Ketoconazole.Approved, Investigational
LabetalolThe metabolism of Labetalol can be decreased when combined with Quinidine.Approved
LamivudineThe serum concentration of Lamivudine can be increased when it is combined with Quinidine.Approved, Investigational
LamotrigineThe serum concentration of Lamotrigine can be increased when it is combined with Quinidine.Approved, Investigational
LansoprazoleThe serum concentration of Lansoprazole can be increased when it is combined with Quinidine.Approved, Investigational
LapatinibLapatinib may increase the QTc-prolonging activities of Quinidine.Approved, Investigational
LedipasvirThe serum concentration of Ledipasvir can be increased when it is combined with Quinidine.Approved
LeflunomideThe metabolism of Quinidine can be decreased when combined with Leflunomide.Approved, Investigational
LenalidomideThe serum concentration of Lenalidomide can be increased when it is combined with Quinidine.Approved
LenvatinibLenvatinib may increase the QTc-prolonging activities of Quinidine.Approved
LeuprolideLeuprolide may increase the QTc-prolonging activities of Quinidine.Approved, Investigational
LevetiracetamThe serum concentration of Levetiracetam can be increased when it is combined with Quinidine.Approved, Investigational
LevodopaThe metabolism of Levodopa can be decreased when combined with Quinidine.Approved
LevofloxacinLevofloxacin may increase the QTc-prolonging activities of Quinidine.Approved, Investigational
Levomethadyl AcetateThe risk or severity of adverse effects can be increased when Quinidine is combined with Levomethadyl Acetate.Approved
LevomilnacipranThe metabolism of Levomilnacipran can be decreased when combined with Quinidine.Approved
LevorphanolThe risk or severity of adverse effects can be increased when Quinidine is combined with Levorphanol.Approved
LevothyroxineThe serum concentration of Quinidine can be decreased when it is combined with Levothyroxine.Approved
LidocaineThe metabolism of Lidocaine can be decreased when combined with Quinidine.Approved, Vet Approved
LinagliptinThe serum concentration of Linagliptin can be increased when it is combined with Quinidine.Approved
LiothyronineThe serum concentration of Quinidine can be decreased when it is combined with Liothyronine.Approved, Vet Approved
LiotrixThe serum concentration of Quinidine can be decreased when it is combined with Liotrix.Approved
LisinoprilThe serum concentration of Quinidine can be increased when it is combined with Lisinopril.Approved, Investigational
LisurideThe metabolism of Lisuride can be decreased when combined with Quinidine.Approved
LithiumLithium may increase the QTc-prolonging activities of Quinidine.Approved
LofentanilThe risk or severity of adverse effects can be increased when Quinidine is combined with Lofentanil.Illicit
LomitapideThe serum concentration of Lomitapide can be increased when it is combined with Quinidine.Approved
LomustineThe metabolism of Lomustine can be decreased when combined with Quinidine.Approved
LoperamideThe metabolism of Loperamide can be decreased when combined with Quinidine.Approved
LopinavirLopinavir may increase the QTc-prolonging activities of Quinidine.Approved
LoratadineThe metabolism of Loratadine can be decreased when combined with Quinidine.Approved
LorcaserinThe metabolism of Lorcaserin can be decreased when combined with Quinidine.Approved
LosartanThe serum concentration of Losartan can be increased when it is combined with Quinidine.Approved
LovastatinThe metabolism of Quinidine can be decreased when combined with Lovastatin.Approved, Investigational
LuliconazoleThe serum concentration of Quinidine can be increased when it is combined with Luliconazole.Approved
LumacaftorThe serum concentration of Quinidine can be increased when it is combined with Lumacaftor.Approved
LumefantrineThe risk or severity of adverse effects can be increased when Quinidine is combined with Lumefantrine.Approved
LurasidoneLurasidone may increase the QTc-prolonging activities of Quinidine.Approved
MagaldrateMagaldrate may decrease the excretion rate of Quinidine which could result in a higher serum level.Withdrawn
Magnesium carbonateMagnesium carbonate may decrease the excretion rate of Quinidine which could result in a higher serum level.Approved
Magnesium hydroxideMagnesium hydroxide may decrease the excretion rate of Quinidine which could result in a higher serum level.Approved
Magnesium oxideMagnesium oxide may decrease the excretion rate of Quinidine which could result in a higher serum level.Approved
Magnesium TrisilicateMagnesium Trisilicate may decrease the excretion rate of Quinidine which could result in a higher serum level.Approved
MalathionThe therapeutic efficacy of Quinidine can be decreased when used in combination with Malathion.Approved, Investigational
MannitolThe serum concentration of Mannitol can be increased when it is combined with Quinidine.Approved, Investigational
MaprotilineMaprotiline may increase the QTc-prolonging activities of Quinidine.Approved
MebendazoleThe serum concentration of Quinidine can be increased when it is combined with Mebendazole.Approved, Vet Approved
MecamylamineThe risk or severity of adverse effects can be increased when Mecamylamine is combined with Quinidine.Approved
MefloquineThe risk or severity of adverse effects can be increased when Quinidine is combined with Mefloquine.Approved
Megestrol acetateThe serum concentration of Quinidine can be increased when it is combined with Megestrol acetate.Approved, Vet Approved
MemantineThe therapeutic efficacy of Quinidine can be decreased when used in combination with Memantine.Approved, Investigational
MephenytoinThe metabolism of Mephenytoin can be decreased when combined with Quinidine.Investigational, Withdrawn
MeprobamateThe serum concentration of Quinidine can be increased when it is combined with Meprobamate.Approved, Illicit
MequitazineThe serum concentration of Mequitazine can be increased when it is combined with Quinidine.Approved
MesoridazineThe metabolism of Mesoridazine can be decreased when combined with Quinidine.Approved
MethadoneMethadone may increase the QTc-prolonging activities of Quinidine.Approved
Methadyl AcetateThe risk or severity of adverse effects can be increased when Quinidine is combined with Methadyl Acetate.Approved, Illicit
MethamphetamineThe metabolism of Methamphetamine can be decreased when combined with Quinidine.Approved, Illicit
Methanesulfonyl FluorideThe therapeutic efficacy of Quinidine can be decreased when used in combination with Methanesulfonyl Fluoride.Investigational
MethanthelineThe risk or severity of adverse effects can be increased when Quinidine is combined with Methantheline.Approved
MethazolamideMethazolamide may decrease the excretion rate of Quinidine which could result in a higher serum level.Approved
MethotrexateThe serum concentration of Methotrexate can be increased when it is combined with Quinidine.Approved
MethotrimeprazineMethotrimeprazine may increase the QTc-prolonging activities of Quinidine.Approved
MethoxyfluraneThe metabolism of Methoxyflurane can be decreased when combined with Quinidine.Approved, Vet Approved
MethyclothiazideThe serum concentration of Methyclothiazide can be increased when it is combined with Quinidine.Approved
Methylene blueThe serum concentration of Methylene blue can be increased when it is combined with Quinidine.Investigational
MethylphenidateThe metabolism of Methylphenidate can be decreased when combined with Quinidine.Approved, Investigational
MethylprednisoloneThe serum concentration of Methylprednisolone can be increased when it is combined with Quinidine.Approved, Vet Approved
MethyprylonThe metabolism of Methyprylon can be decreased when combined with Quinidine.Approved, Illicit, Withdrawn
MetixeneThe risk or severity of adverse effects can be increased when Quinidine is combined with Metixene.Approved
MetoclopramideMetoclopramide may increase the QTc-prolonging activities of Quinidine.Approved, Investigational
MetocurineQuinidine may increase the neuromuscular blocking activities of Metocurine.Approved
Metocurine IodideQuinidine may increase the neuromuscular blocking activities of Metocurine Iodide.Withdrawn
MetolazoneThe serum concentration of Metolazone can be increased when it is combined with Quinidine.Approved
MetoprololThe serum concentration of Metoprolol can be increased when it is combined with Quinidine.Approved, Investigational
MetronidazoleMetronidazole may increase the QTc-prolonging activities of Quinidine.Approved
MevastatinThe metabolism of Quinidine can be decreased when combined with Mevastatin.Experimental
MexiletineThe metabolism of Mexiletine can be decreased when combined with Quinidine.Approved
MianserinMianserin may increase the anticholinergic activities of Quinidine.Approved
MibefradilThe serum concentration of Quinidine can be increased when it is combined with Mibefradil.Withdrawn
MicafunginThe metabolism of Quinidine can be decreased when combined with Micafungin.Approved, Investigational
MiconazoleThe metabolism of Quinidine can be decreased when combined with Miconazole.Approved, Investigational, Vet Approved
MidazolamThe serum concentration of Quinidine can be decreased when it is combined with Midazolam.Approved, Illicit
MifepristoneMifepristone may increase the QTc-prolonging activities of Quinidine.Approved, Investigational
MiltefosineThe metabolism of Quinidine can be decreased when combined with Miltefosine.Approved
MinaprineThe metabolism of Minaprine can be decreased when combined with Quinidine.Approved
MirabegronThe risk or severity of adverse effects can be increased when Quinidine is combined with Mirabegron.Approved
MirtazapineMirtazapine may increase the QTc-prolonging activities of Quinidine.Approved
MitomycinThe serum concentration of Quinidine can be increased when it is combined with Mitomycin.Approved
MitotaneThe serum concentration of Quinidine can be decreased when it is combined with Mitotane.Approved
MitoxantroneThe serum concentration of Quinidine can be decreased when it is combined with Mitoxantrone.Approved, Investigational
MivacuriumQuinidine may increase the neuromuscular blocking activities of Mivacurium.Approved
MoclobemideThe metabolism of Moclobemide can be decreased when combined with Quinidine.Approved
ModafinilThe serum concentration of Quinidine can be decreased when it is combined with Modafinil.Approved, Investigational
MoexiprilMoexipril may increase the QTc-prolonging activities of Quinidine.Approved
MonensinThe metabolism of Quinidine can be decreased when combined with Monensin.Vet Approved
MoricizineThe serum concentration of Moricizine can be increased when it is combined with Quinidine.Approved, Withdrawn
MorphineThe metabolism of Morphine can be decreased when combined with Quinidine.Approved, Investigational
MoxifloxacinMoxifloxacin may increase the QTc-prolonging activities of Quinidine.Approved, Investigational
Mycophenolate mofetilThe serum concentration of Mycophenolate mofetil can be increased when it is combined with Quinidine.Approved, Investigational
MyxothiazolThe metabolism of Quinidine can be decreased when combined with Myxothiazol.Experimental
N-butylscopolammonium bromideThe risk or severity of adverse effects can be increased when Quinidine is combined with N-butylscopolammonium bromide.Vet Approved
NabiloneQuinidine may increase the tachycardic activities of Nabilone.Approved, Investigational
NadololThe serum concentration of Nadolol can be increased when it is combined with Quinidine.Approved
NafcillinThe serum concentration of Quinidine can be decreased when it is combined with Nafcillin.Approved
NaftifineThe metabolism of Quinidine can be decreased when combined with Naftifine.Approved
NalbuphineThe risk or severity of adverse effects can be increased when Quinidine is combined with Nalbuphine.Approved
NaloxegolThe serum concentration of Naloxegol can be increased when it is combined with Quinidine.Approved
NaloxoneThe serum concentration of Naloxone can be increased when it is combined with Quinidine.Approved, Vet Approved
NaltrexoneThe serum concentration of Quinidine can be increased when it is combined with Naltrexone.Approved, Investigational, Vet Approved
NaringeninThe serum concentration of Quinidine can be increased when it is combined with Naringenin.Experimental
NatamycinThe metabolism of Quinidine can be decreased when combined with Natamycin.Approved
NateglinideThe metabolism of Nateglinide can be decreased when combined with Quinidine.Approved, Investigational
NebivololThe serum concentration of Nebivolol can be increased when it is combined with Quinidine.Approved, Investigational
NefazodoneThe metabolism of Quinidine can be decreased when combined with Nefazodone.Approved, Withdrawn
NelfinavirThe serum concentration of Quinidine can be increased when it is combined with Nelfinavir.Approved
NeosaxitoxinQuinidine may increase the neuromuscular blocking activities of Neosaxitoxin.Investigational
NeostigmineThe therapeutic efficacy of Quinidine can be decreased when used in combination with Neostigmine.Approved, Vet Approved
NetupitantThe serum concentration of Quinidine can be increased when it is combined with Netupitant.Approved
NevirapineThe metabolism of Quinidine can be increased when combined with Nevirapine.Approved
NicardipineThe serum concentration of Quinidine can be decreased when it is combined with Nicardipine.Approved
NicergolineThe metabolism of Nicergoline can be decreased when combined with Quinidine.Approved
NicotineThe metabolism of Nicotine can be decreased when combined with Quinidine.Approved
NifedipineThe serum concentration of Quinidine can be decreased when it is combined with Nifedipine.Approved
NilotinibQuinidine may increase the QTc-prolonging activities of Nilotinib.Approved, Investigational
NimodipineThe serum concentration of Nimodipine can be increased when it is combined with Quinidine.Approved
NintedanibThe serum concentration of Nintedanib can be increased when it is combined with Quinidine.Approved
NisoldipineThe serum concentration of Quinidine can be decreased when it is combined with Nisoldipine.Approved
NitrazepamThe serum concentration of Quinidine can be increased when it is combined with Nitrazepam.Approved
NitrendipineThe serum concentration of Quinidine can be increased when it is combined with Nitrendipine.Approved
NitrofuralThe metabolism of Nitrofural can be decreased when combined with Quinidine.Approved, Vet Approved
NitroxolineThe metabolism of Quinidine can be decreased when combined with Nitroxoline.Approved
NizatidineThe serum concentration of Nizatidine can be increased when it is combined with Quinidine.Approved
NorethisteroneThe serum concentration of Quinidine can be decreased when it is combined with Norethisterone.Approved
NorfloxacinNorfloxacin may increase the QTc-prolonging activities of Quinidine.Approved
NormethadoneThe risk or severity of adverse effects can be increased when Quinidine is combined with Normethadone.Approved, Illicit
NortriptylineNortriptyline may increase the QTc-prolonging activities of Quinidine.Approved
NVA237The risk or severity of adverse effects can be increased when Quinidine is combined with NVA237.Investigational
NystatinThe metabolism of Quinidine can be decreased when combined with Nystatin.Approved, Vet Approved
OctreotideOctreotide may increase the QTc-prolonging activities of Quinidine.Approved, Investigational
OfloxacinOfloxacin may increase the QTc-prolonging activities of Quinidine.Approved
OlanzapineOlanzapine may increase the QTc-prolonging activities of Quinidine.Approved, Investigational
OlaparibThe metabolism of Quinidine can be decreased when combined with Olaparib.Approved
OlodaterolOlodaterol may increase the QTc-prolonging activities of Quinidine.Approved
OmbitasvirThe serum concentration of Quinidine can be increased when it is combined with Ombitasvir.Approved
OmeprazoleThe serum concentration of Quinidine can be increased when it is combined with Omeprazole.Approved, Investigational, Vet Approved
OndansetronOndansetron may increase the QTc-prolonging activities of Quinidine.Approved
OpipramolOpipramol may increase the QTc-prolonging activities of Quinidine.Investigational
OpiumThe risk or severity of adverse effects can be increased when Quinidine is combined with Opium.Approved, Illicit
OrphenadrineThe risk or severity of adverse effects can be increased when Quinidine is combined with Orphenadrine.Approved
OsimertinibThe serum concentration of Quinidine can be increased when it is combined with Osimertinib.Approved
OuabainThe serum concentration of Ouabain can be increased when it is combined with Quinidine.Approved
OxiconazoleThe metabolism of Quinidine can be decreased when combined with Oxiconazole.Approved
OxybutyninThe risk or severity of adverse effects can be increased when Quinidine is combined with Oxybutynin.Approved, Investigational
OxycodoneThe metabolism of Oxycodone can be decreased when combined with Quinidine.Approved, Illicit, Investigational
OxymorphoneThe metabolism of Oxymorphone can be decreased when combined with Quinidine.Approved, Investigational, Vet Approved
OxyphenoniumThe risk or severity of adverse effects can be increased when Oxyphenonium is combined with Quinidine.Approved
OxytocinOxytocin may increase the QTc-prolonging activities of Quinidine.Approved, Vet Approved
P-NitrophenolThe serum concentration of Quinidine can be increased when it is combined with P-Nitrophenol.Experimental
PaclitaxelThe serum concentration of Paclitaxel can be increased when it is combined with Quinidine.Approved, Vet Approved
pafuramidineThe metabolism of Quinidine can be decreased when combined with pafuramidine.Investigational
PalbociclibThe serum concentration of Quinidine can be increased when it is combined with Palbociclib.Approved
PaliperidoneQuinidine may increase the QTc-prolonging activities of Paliperidone.Approved
Palmitic AcidThe serum concentration of Quinidine can be increased when it is combined with Palmitic Acid.Experimental
PalonosetronThe metabolism of Palonosetron can be decreased when combined with Quinidine.Approved, Investigational
PancuroniumQuinidine may increase the neuromuscular blocking activities of Pancuronium.Approved
PanobinostatPanobinostat may increase the QTc-prolonging activities of Quinidine.Approved, Investigational
PantoprazoleThe serum concentration of Quinidine can be increased when it is combined with Pantoprazole.Approved
ParitaprevirThe serum concentration of Quinidine can be increased when it is combined with Paritaprevir.Approved
ParoxetineParoxetine may increase the QTc-prolonging activities of Quinidine.Approved, Investigational
PasireotidePasireotide may increase the QTc-prolonging activities of Quinidine.Approved
PazopanibThe serum concentration of Pazopanib can be increased when it is combined with Quinidine.Approved
PentamidineThe metabolism of Quinidine can be decreased when combined with Pentamidine.Approved
PentazocineThe risk or severity of adverse effects can be increased when Quinidine is combined with Pentazocine.Approved, Vet Approved
PentobarbitalThe metabolism of Quinidine can be increased when combined with Pentobarbital.Approved, Vet Approved
PentoliniumThe risk or severity of adverse effects can be increased when Quinidine is combined with Pentolinium.Approved
PerazineThe serum concentration of Perazine can be increased when it is combined with Quinidine.Investigational
PerflutrenPerflutren may increase the QTc-prolonging activities of Quinidine.Approved
PerhexilineThe metabolism of Perhexiline can be decreased when combined with Quinidine.Approved
PerindoprilThe serum concentration of Quinidine can be increased when it is combined with Perindopril.Approved
PerphenazineThe metabolism of Perphenazine can be decreased when combined with Quinidine.Approved
PethidineThe metabolism of Pethidine can be decreased when combined with Quinidine.Approved
PhenacetinThe metabolism of Phenacetin can be decreased when combined with Quinidine.Withdrawn
PhenforminThe metabolism of Phenformin can be decreased when combined with Quinidine.Approved, Withdrawn
PhenindioneQuinidine may increase the anticoagulant activities of Phenindione.Approved
PhenobarbitalPhenobarbital may increase the hepatotoxic activities of Quinidine.Approved
PhenprocoumonQuinidine may increase the anticoagulant activities of Phenprocoumon.Approved
PhenytoinThe serum concentration of Quinidine can be decreased when it is combined with Phenytoin.Approved, Vet Approved
PhysostigmineThe therapeutic efficacy of Quinidine can be decreased when used in combination with Physostigmine.Approved
PimozideThe serum concentration of Pimozide can be increased when it is combined with Quinidine.Approved
PindololThe metabolism of Pindolol can be decreased when combined with Quinidine.Approved
PioglitazoneThe metabolism of Quinidine can be decreased when combined with Pioglitazone.Approved, Investigational
PipecuroniumQuinidine may increase the neuromuscular blocking activities of Pipecuronium.Approved
PiperazineThe metabolism of Piperazine can be decreased when combined with Quinidine.Approved, Vet Approved
PipotiazineThe metabolism of Pipotiazine can be decreased when combined with Quinidine.Approved
PirenzepineThe risk or severity of adverse effects can be increased when Pirenzepine is combined with Quinidine.Approved
PiritramideThe risk or severity of adverse effects can be increased when Quinidine is combined with Piritramide.Investigational
PitavastatinThe serum concentration of Pitavastatin can be increased when it is combined with Quinidine.Approved
Platelet Activating FactorThe serum concentration of Quinidine can be decreased when it is combined with Platelet Activating Factor.Experimental
PolythiazideThe serum concentration of Polythiazide can be increased when it is combined with Quinidine.Approved
PomalidomideThe serum concentration of Pomalidomide can be increased when it is combined with Quinidine.Approved
PonatinibThe metabolism of Ponatinib can be decreased when combined with Quinidine.Approved
PosaconazoleThe metabolism of Quinidine can be decreased when combined with Posaconazole.Approved, Investigational, Vet Approved
Potassium ChlorideQuinidine may increase the ulcerogenic activities of Potassium Chloride.Approved, Withdrawn
PramlintidePramlintide may increase the anticholinergic activities of Quinidine.Approved, Investigational
PravastatinThe serum concentration of Pravastatin can be increased when it is combined with Quinidine.Approved
PrazosinThe serum concentration of Prazosin can be increased when it is combined with Quinidine.Approved
PrednisoloneThe serum concentration of Prednisolone can be increased when it is combined with Quinidine.Approved, Vet Approved
PrednisoneThe serum concentration of Prednisone can be increased when it is combined with Quinidine.Approved, Vet Approved
PrimaquinePrimaquine may increase the QTc-prolonging activities of Quinidine.Approved
PrimidoneThe serum concentration of Quinidine can be decreased when it is combined with Primidone.Approved, Vet Approved
ProbenecidThe serum concentration of Quinidine can be increased when it is combined with Probenecid.Approved
ProcainamideQuinidine may increase the QTc-prolonging activities of Procainamide.Approved
ProchlorperazineThe metabolism of Prochlorperazine can be decreased when combined with Quinidine.Approved, Vet Approved
ProcyclidineThe risk or severity of adverse effects can be increased when Procyclidine is combined with Quinidine.Approved
ProgesteroneThe metabolism of Progesterone can be decreased when combined with Quinidine.Approved, Vet Approved
PromazinePromazine may increase the QTc-prolonging activities of Quinidine.Approved, Vet Approved
PromethazinePromethazine may increase the QTc-prolonging activities of Quinidine.Approved
PropafenoneQuinidine may increase the QTc-prolonging activities of Propafenone.Approved
PropanthelineThe risk or severity of adverse effects can be increased when Propantheline is combined with Quinidine.Approved
PropiopromazineThe serum concentration of Propiopromazine can be increased when it is combined with Quinidine.Vet Approved
PropiverineThe risk or severity of adverse effects can be increased when Quinidine is combined with Propiverine.Investigational
PropofolPropofol may increase the QTc-prolonging activities of Quinidine.Approved, Investigational, Vet Approved
PropranololThe serum concentration of Propranolol can be increased when it is combined with Quinidine.Approved, Investigational
ProtriptylineProtriptyline may increase the QTc-prolonging activities of Quinidine.Approved
PrucaloprideThe serum concentration of Prucalopride can be increased when it is combined with Quinidine.Approved
PseudoephedrineThe metabolism of Pseudoephedrine can be decreased when combined with Quinidine.Approved
PyrantelQuinidine may increase the neuromuscular blocking activities of Pyrantel.Approved, Vet Approved
PyridostigmineThe therapeutic efficacy of Quinidine can be decreased when used in combination with Pyridostigmine.Approved
PyrimethamineThe metabolism of Quinidine can be decreased when combined with Pyrimethamine.Approved, Vet Approved
QuercetinThe serum concentration of Quinidine can be increased when it is combined with Quercetin.Experimental
QuetiapineQuinidine may increase the QTc-prolonging activities of Quetiapine.Approved
QuinacrineThe serum concentration of Quinidine can be increased when it is combined with Quinacrine.Approved
QuinethazoneThe serum concentration of Quinethazone can be increased when it is combined with Quinidine.Approved
QuinineQuinine may increase the QTc-prolonging activities of Quinidine.Approved
RabeprazoleThe metabolism of Quinidine can be decreased when combined with Rabeprazole.Approved, Investigational
RadicicolThe metabolism of Quinidine can be decreased when combined with Radicicol.Experimental
RamosetronQuinidine may increase the constipating activities of Ramosetron.Approved
RanitidineThe metabolism of Ranitidine can be decreased when combined with Quinidine.Approved
RanolazineThe serum concentration of Ranolazine can be increased when it is combined with Quinidine.Approved, Investigational
RapacuroniumQuinidine may increase the neuromuscular blocking activities of Rapacuronium.Withdrawn
ReboxetineThe serum concentration of Quinidine can be increased when it is combined with Reboxetine.Approved, Investigational
RegorafenibThe serum concentration of Quinidine can be increased when it is combined with Regorafenib.Approved
RemifentanilThe risk or severity of adverse effects can be increased when Quinidine is combined with Remifentanil.Approved
RemoxiprideThe metabolism of Remoxipride can be decreased when combined with Quinidine.Approved, Withdrawn
repinotanThe metabolism of repinotan can be decreased when combined with Quinidine.Investigational
ReserpineThe risk or severity of adverse effects can be increased when Reserpine is combined with Quinidine.Approved
RifabutinThe serum concentration of Quinidine can be decreased when it is combined with Rifabutin.Approved
RifampicinThe serum concentration of Quinidine can be decreased when it is combined with Rifampicin.Approved
RifapentineThe serum concentration of Quinidine can be decreased when it is combined with Rifapentine.Approved
RifaximinThe serum concentration of Rifaximin can be increased when it is combined with Quinidine.Approved, Investigational
RilpivirineRilpivirine may increase the QTc-prolonging activities of Quinidine.Approved
RisperidoneRisperidone may increase the QTc-prolonging activities of Quinidine.Approved, Investigational
RitonavirThe serum concentration of Quinidine can be increased when it is combined with Ritonavir.Approved, Investigational
RivaroxabanThe serum concentration of Rivaroxaban can be increased when it is combined with Quinidine.Approved
RivastigmineThe therapeutic efficacy of Quinidine can be decreased when used in combination with Rivastigmine.Approved, Investigational
RocuroniumQuinidine may increase the neuromuscular blocking activities of Rocuronium.Approved
RolapitantThe serum concentration of Quinidine can be increased when it is combined with Rolapitant.Approved
RomidepsinThe serum concentration of Romidepsin can be increased when it is combined with Quinidine.Approved, Investigational
RopivacaineThe metabolism of Ropivacaine can be decreased when combined with Quinidine.Approved
RosiglitazoneThe metabolism of Quinidine can be decreased when combined with Rosiglitazone.Approved, Investigational
RotigotineThe metabolism of Rotigotine can be decreased when combined with Quinidine.Approved
SalbutamolSalbutamol may increase the QTc-prolonging activities of Quinidine.Approved, Vet Approved
Salicylhydroxamic AcidThe metabolism of Quinidine can be decreased when combined with Salicylhydroxamic Acid.Experimental
Salicylic acidThe metabolism of Quinidine can be decreased when combined with Salicylic acid.Approved, Vet Approved
SalmeterolSalmeterol may increase the QTc-prolonging activities of Quinidine.Approved
SaquinavirSaquinavir may increase the QTc-prolonging activities of Quinidine.Approved, Investigational
SaxagliptinThe serum concentration of Saxagliptin can be decreased when it is combined with Quinidine.Approved
ScopolamineThe risk or severity of adverse effects can be increased when Scopolamine is combined with Quinidine.Approved
Scopolamine butylbromideThe risk or severity of adverse effects can be increased when Quinidine is combined with Scopolamine butylbromide.Approved
SecobarbitalThe metabolism of Quinidine can be increased when combined with Secobarbital.Approved, Vet Approved
SecretinThe therapeutic efficacy of Secretin can be decreased when used in combination with Quinidine.Approved, Investigational
SelegilineThe serum concentration of Quinidine can be increased when it is combined with Selegiline.Approved, Investigational, Vet Approved
SelexipagThe serum concentration of Selexipag can be increased when it is combined with Quinidine.Approved
SertaconazoleThe metabolism of Quinidine can be decreased when combined with Sertaconazole.Approved
SertindoleThe metabolism of Sertindole can be decreased when combined with Quinidine.Approved, Withdrawn
SertralineSertraline may increase the QTc-prolonging activities of Quinidine.Approved
SevofluraneSevoflurane may increase the QTc-prolonging activities of Quinidine.Approved, Vet Approved
SildenafilThe metabolism of Sildenafil can be decreased when combined with Quinidine.Approved, Investigational
SilodosinThe serum concentration of Silodosin can be increased when it is combined with Quinidine.Approved
SiltuximabThe serum concentration of Quinidine can be decreased when it is combined with Siltuximab.Approved
SimeprevirThe serum concentration of Quinidine can be increased when it is combined with Simeprevir.Approved
SimvastatinThe metabolism of Simvastatin can be decreased when combined with Quinidine.Approved
SinefunginThe metabolism of Quinidine can be decreased when combined with Sinefungin.Experimental
SirolimusThe metabolism of Quinidine can be decreased when combined with Sirolimus.Approved, Investigational
SitagliptinThe serum concentration of Sitagliptin can be increased when it is combined with Quinidine.Approved, Investigational
SofosbuvirThe serum concentration of Sofosbuvir can be increased when it is combined with Quinidine.Approved
SolifenacinSolifenacin may increase the QTc-prolonging activities of Quinidine.Approved
SorafenibSorafenib may increase the QTc-prolonging activities of Quinidine.Approved, Investigational
SotalolSotalol may increase the QTc-prolonging activities of Quinidine.Approved
SparfloxacinThe serum concentration of Sparfloxacin can be increased when it is combined with Quinidine.Approved
SparteineThe metabolism of Sparteine can be decreased when combined with Quinidine.Experimental
SphingosineThe serum concentration of Sphingosine can be increased when it is combined with Quinidine.Experimental
SpironolactoneThe therapeutic efficacy of Quinidine can be decreased when used in combination with Spironolactone.Approved
St. John's WortThe serum concentration of Quinidine can be decreased when it is combined with St. John's Wort.Nutraceutical
StaurosporineThe serum concentration of Quinidine can be increased when it is combined with Staurosporine.Experimental
StiripentolThe serum concentration of Quinidine can be increased when it is combined with Stiripentol.Approved
StreptozocinThe serum concentration of Quinidine can be decreased when it is combined with Streptozocin.Approved
SuccinylcholineQuinidine may increase the neuromuscular blocking activities of Succinylcholine.Approved
SucralfateThe serum concentration of Quinidine can be decreased when it is combined with Sucralfate.Approved
SufentanilThe risk or severity of adverse effects can be increased when Quinidine is combined with Sufentanil.Approved, Investigational
SulconazoleThe metabolism of Quinidine can be decreased when combined with Sulconazole.Approved
SulfadiazineThe metabolism of Quinidine can be decreased when combined with Sulfadiazine.Approved, Vet Approved
SulfamethoxazoleSulfamethoxazole may increase the QTc-prolonging activities of Quinidine.Approved
SulfinpyrazoneThe serum concentration of Quinidine can be increased when it is combined with Sulfinpyrazone.Approved
SulfisoxazoleSulfisoxazole may increase the QTc-prolonging activities of Quinidine.Approved, Vet Approved
SulpirideThe therapeutic efficacy of Sulpiride can be decreased when used in combination with Quinidine.Approved
SumatriptanThe serum concentration of Quinidine can be increased when it is combined with Sumatriptan.Approved, Investigational
SunitinibSunitinib may increase the QTc-prolonging activities of Quinidine.Approved, Investigational
TacrineThe therapeutic efficacy of Quinidine can be decreased when used in combination with Tacrine.Withdrawn
TacrolimusThe serum concentration of Quinidine can be decreased when it is combined with Tacrolimus.Approved, Investigational
TamoxifenThe serum concentration of the active metabolites of Tamoxifen can be reduced when Tamoxifen is used in combination with Quinidine resulting in a loss in efficacy.Approved
TamsulosinThe serum concentration of Tamsulosin can be increased when it is combined with Quinidine.Approved, Investigational
TapentadolThe metabolism of Tapentadol can be decreased when combined with Quinidine.Approved
Taurocholic AcidThe serum concentration of Taurocholic Acid can be increased when it is combined with Quinidine.Experimental
TavaboroleThe metabolism of Quinidine can be decreased when combined with Tavaborole.Approved
Technetium Tc-99m sestamibiThe serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Quinidine.Approved
TegaserodThe metabolism of Tegaserod can be decreased when combined with Quinidine.Investigational, Withdrawn
TelaprevirThe risk or severity of adverse effects can be increased when Telaprevir is combined with Quinidine.Approved
TelavancinTelavancin may increase the QTc-prolonging activities of Quinidine.Approved
TelithromycinTelithromycin may increase the QTc-prolonging activities of Quinidine.Approved
TelmisartanThe serum concentration of Quinidine can be increased when it is combined with Telmisartan.Approved, Investigational
TemsirolimusThe serum concentration of Temsirolimus can be increased when it is combined with Quinidine.Approved
TerazosinThe serum concentration of Quinidine can be increased when it is combined with Terazosin.Approved
TerbinafineThe metabolism of Quinidine can be decreased when combined with Terbinafine.Approved, Investigational, Vet Approved
TerbutalineTerbutaline may increase the QTc-prolonging activities of Quinidine.Approved
TerconazoleThe metabolism of Quinidine can be decreased when combined with Terconazole.Approved
TerfenadineThe metabolism of Terfenadine can be decreased when combined with Quinidine.Withdrawn
TeriflunomideThe metabolism of Quinidine can be decreased when combined with Teriflunomide.Approved
TesmilifeneThe metabolism of Tesmilifene can be decreased when combined with Quinidine.Investigational
TestosteroneThe serum concentration of Quinidine can be increased when it is combined with Testosterone.Approved, Investigational
TetrabenazineThe serum concentration of Tetrabenazine can be increased when it is combined with Quinidine.Approved
TheophyllineThe metabolism of Theophylline can be decreased when combined with Quinidine.Approved
ThiethylperazineThe serum concentration of Thiethylperazine can be increased when it is combined with Quinidine.Withdrawn
ThioridazineThe serum concentration of Thioridazine can be increased when it is combined with Quinidine.Approved
ThiothixeneThiothixene may increase the QTc-prolonging activities of Quinidine.Approved
ThymolThe metabolism of Quinidine can be decreased when combined with Thymol.Approved
TianeptineTianeptine may increase the QTc-prolonging activities of Quinidine.Approved
TicagrelorThe serum concentration of Ticagrelor can be increased when it is combined with Quinidine.Approved
TiclopidineThe metabolism of Ticlopidine can be decreased when combined with Quinidine.Approved
TimololThe metabolism of Timolol can be decreased when combined with Quinidine.Approved
TioconazoleThe metabolism of Quinidine can be decreased when combined with Tioconazole.Approved
TiotropiumQuinidine may increase the anticholinergic activities of Tiotropium.Approved
TipranavirThe serum concentration of Quinidine can be increased when it is combined with Tipranavir.Approved, Investigational
TizanidineTizanidine may increase the QTc-prolonging activities of Quinidine.Approved
TocilizumabThe serum concentration of Quinidine can be decreased when it is combined with Tocilizumab.Approved
TolbutamideThe metabolism of Quinidine can be decreased when combined with Tolbutamide.Approved
TolnaftateThe metabolism of Quinidine can be decreased when combined with Tolnaftate.Approved, Vet Approved
TolterodineTolterodine may increase the QTc-prolonging activities of Quinidine.Approved, Investigational
TolvaptanThe serum concentration of Tolvaptan can be increased when it is combined with Quinidine.Approved
TopiramateThe risk or severity of adverse effects can be increased when Quinidine is combined with Topiramate.Approved
TopotecanThe serum concentration of Topotecan can be increased when it is combined with Quinidine.Approved, Investigational
ToremifeneToremifene may increase the QTc-prolonging activities of Quinidine.Approved, Investigational
TrabectedinThe metabolism of Trabectedin can be decreased when combined with Quinidine.Approved, Investigational
TramadolThe therapeutic efficacy of Tramadol can be decreased when used in combination with Quinidine.Approved, Investigational
Trastuzumab emtansineThe serum concentration of Trastuzumab emtansine can be increased when it is combined with Quinidine.Approved
TrazodoneTrazodone may increase the QTc-prolonging activities of Quinidine.Approved, Investigational
TreprostinilTreprostinil may increase the QTc-prolonging activities of Quinidine.Approved, Investigational
TriamtereneThe therapeutic efficacy of Quinidine can be decreased when used in combination with Triamterene.Approved
TrichlorfonThe therapeutic efficacy of Quinidine can be decreased when used in combination with Trichlorfon.Vet Approved
TrichlormethiazideThe serum concentration of Trichlormethiazide can be increased when it is combined with Quinidine.Approved, Vet Approved
TrifluoperazineThe serum concentration of Trifluoperazine can be increased when it is combined with Quinidine.Approved
TriflupromazineThe serum concentration of Triflupromazine can be increased when it is combined with Quinidine.Approved, Vet Approved
TrihexyphenidylThe risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Quinidine.Approved
TrimethaphanThe risk or severity of adverse effects can be increased when Quinidine is combined with Trimethaphan.Approved
TrimethoprimTrimethoprim may increase the QTc-prolonging activities of Quinidine.Approved, Vet Approved
TrimetrexateThe metabolism of Quinidine can be decreased when combined with Trimetrexate.Approved, Investigational
TrimipramineTrimipramine may increase the QTc-prolonging activities of Quinidine.Approved
TriptorelinTriptorelin may increase the QTc-prolonging activities of Quinidine.Approved, Vet Approved
TroleandomycinThe serum concentration of Quinidine can be increased when it is combined with Troleandomycin.Approved
TropicamideThe risk or severity of adverse effects can be increased when Tropicamide is combined with Quinidine.Approved
TrospiumThe risk or severity of adverse effects can be increased when Trospium is combined with Quinidine.Approved
TubocurarineQuinidine may increase the neuromuscular blocking activities of Tubocurarine.Approved
UlipristalThe serum concentration of Ulipristal can be increased when it is combined with Quinidine.Approved
UmeclidiniumUmeclidinium may increase the anticholinergic activities of Quinidine.Approved
Valproic AcidThe metabolism of Quinidine can be decreased when combined with Valproic Acid.Approved, Investigational
ValsartanThe metabolism of Quinidine can be decreased when combined with Valsartan.Approved, Investigational
VandetanibQuinidine may increase the QTc-prolonging activities of Vandetanib.Approved
VardenafilVardenafil may increase the QTc-prolonging activities of Quinidine.Approved
VecuroniumQuinidine may increase the neuromuscular blocking activities of Vecuronium.Approved
VemurafenibQuinidine may increase the QTc-prolonging activities of Vemurafenib.Approved
VenetoclaxThe serum concentration of Venetoclax can be increased when it is combined with Quinidine.Approved
VenlafaxineVenlafaxine may increase the QTc-prolonging activities of Quinidine.Approved
VerapamilQuinidine may increase the hypotensive activities of Verapamil.Approved
VilanterolVilanterol may increase the QTc-prolonging activities of Quinidine.Approved
VilazodoneThe metabolism of Vilazodone can be decreased when combined with Quinidine.Approved
VinblastineThe metabolism of Vinblastine can be decreased when combined with Quinidine.Approved
VincristineThe serum concentration of Vincristine can be increased when it is combined with Quinidine.Approved, Investigational
VincristineThe serum concentration of Quinidine can be decreased when it is combined with Vincristine.Approved, Investigational
VinorelbineThe metabolism of Vinorelbine can be decreased when combined with Quinidine.Approved, Investigational
VismodegibThe serum concentration of Vismodegib can be increased when it is combined with Quinidine.Approved
VoriconazoleThe metabolism of Quinidine can be decreased when combined with Voriconazole.Approved, Investigational
VorinostatVorinostat may increase the QTc-prolonging activities of Quinidine.Approved, Investigational
VortioxetineThe serum concentration of Vortioxetine can be increased when it is combined with Quinidine.Approved
WarfarinQuinidine may increase the anticoagulant activities of Warfarin.Approved
YohimbineThe metabolism of Yohimbine can be decreased when combined with Quinidine.Approved, Vet Approved
ZafirlukastThe metabolism of Quinidine can be decreased when combined with Zafirlukast.Approved, Investigational
ZalcitabineThe metabolism of Zalcitabine can be decreased when combined with Quinidine.Approved
ZidovudineThe serum concentration of Zidovudine can be increased when it is combined with Quinidine.Approved
ZimelidineThe serum concentration of Quinidine can be increased when it is combined with Zimelidine.Withdrawn
ZiprasidoneZiprasidone may increase the QTc-prolonging activities of Quinidine.Approved
ZolpidemThe metabolism of Zolpidem can be decreased when combined with Quinidine.Approved
ZuclopenthixolQuinidine may increase the QTc-prolonging activities of Zuclopenthixol.Approved, Investigational
Food Interactions
  • Preferably take on an ampty stomach.
References
Synthesis Reference

Jean Paul REMON, Chris Vervaet, “QUININE AND QUINIDINE SALTS, METHODS FOR MAKING THEM, AND PHARMACEUTICAL FORMULATIONS COMPRISING THEM.” U.S. Patent US20090239900, issued September 24, 2009.

US20090239900
General ReferencesNot Available
External Links
ATC CodesC01BA01C01BA51C01BA71
AHFS Codes
  • 24:04.04.04
PDB EntriesNot Available
FDA labelDownload (615 KB)
MSDSDownload (73 KB)
ADMET
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9836
Blood Brain Barrier+0.9382
Caco-2 permeable+0.8867
P-glycoprotein substrateSubstrate0.7863
P-glycoprotein inhibitor IInhibitor0.8208
P-glycoprotein inhibitor IIInhibitor0.8387
Renal organic cation transporterInhibitor0.762
CYP450 2C9 substrateNon-substrate0.7898
CYP450 2D6 substrateNon-substrate0.9116
CYP450 3A4 substrateSubstrate0.5754
CYP450 1A2 substrateNon-inhibitor0.9045
CYP450 2C9 inhibitorNon-inhibitor0.9071
CYP450 2D6 inhibitorInhibitor0.8931
CYP450 2C19 inhibitorNon-inhibitor0.9026
CYP450 3A4 inhibitorNon-inhibitor0.8309
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.7225
Ames testNon AMES toxic0.9133
CarcinogenicityNon-carcinogens0.972
BiodegradationNot ready biodegradable1.0
Rat acute toxicity3.0596 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Strong inhibitor0.5884
hERG inhibition (predictor II)Inhibitor0.538
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Pharmacoeconomics
Manufacturers
  • Eli lilly and co
  • Warner chilcott div warner lambert co
  • Bayer healthcare pharmaceuticals inc
  • Lannett co inc
  • Watson laboratories inc
  • Ascot hosp pharmaceuticals inc div travenol laboratories inc
  • Halsey drug co inc
  • Mutual pharmaceutical co inc
  • Roxane laboratories inc
  • Sandoz inc
  • Superpharm corp
  • Pharmaceutical research assoc inc
  • Solvay pharmaceuticals
  • Wyeth pharmaceuticals inc
  • Teva pharmaceuticals usa
  • Barr laboratories inc
  • Clonmel healthcare ltd
  • Contract pharmacal corp
  • Elkins sinn div ah robins co inc
  • Everylife
  • Impax laboratories inc
  • Ivax pharmaceuticals inc sub teva pharmaceuticals usa
  • King pharmaceuticals inc
  • Kv pharmaceutical co
  • Lederle laboratories div american cyanamid co
  • L perrigo co
  • Pharmavite pharmaceuticals
  • Purepac pharmaceutical co
  • Scherer laboratories inc
  • Usl pharma inc
  • Valeant pharmaceuticals international
  • Vangard laboratories inc div midway medical co
  • Vintage pharmaceuticals inc
  • West ward pharmaceutical corp
  • Whiteworth towne paulsen inc
  • Key pharmaceuticals inc sub schering plough corp
  • Schering corp
Packagers
Dosage forms
FormRouteStrength
TabletOral275 mg
Capsule, gelatin coatedOral
TabletOral325 mg
Tablet, extended releaseOral300 mg
SolutionIntravenous80 mg/mL
Tablet, extended releaseOral324 mg/1
LiquidIntramuscular; Intravenous80 mg
TabletOral200 mg/1
TabletOral300 mg/1
Tablet, film coated, extended releaseOral300 mg/1
SolutionIntramuscular190 mg
TabletOral195 mg
TabletOral200 mg
Prices
Unit descriptionCostUnit
Quinidine gluc 80 mg/ml vial2.16USD ml
Quinidine sulfate crystals1.58USD g
QuiNIDine Gluconate CR 324 mg Controlled Release Tabs0.97USD tab
Quinidine gluc er 324 mg tab0.93USD each
Quinidine Sulfate 300 mg0.41USD tablet
Quinidine sulfate 300 mg tablet0.4USD tablet
Quinidine Sulfate 200 mg0.22USD tablet
Quinidine sulfate 200 mg tablet0.21USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US7659282 No2006-08-132026-08-13Us
US8227484 No2003-07-172023-07-17Us
USRE38115 No1996-01-262016-01-26Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point174 °CPhysProp
water solubility140 mg/L (at 25 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP3.44HANSCH,C ET AL. (1995)
logS-3.37ADME Research, USCD
Caco2 permeability-4.69ADME Research, USCD
pKa8.56 (at 25 °C)SANGSTER (1994)
Predicted Properties
PropertyValueSource
Water Solubility0.334 mg/mLALOGPS
logP2.82ALOGPS
logP2.51ChemAxon
logS-3ALOGPS
pKa (Strongest Acidic)13.89ChemAxon
pKa (Strongest Basic)9.05ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area45.59 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity94.69 m3·mol-1ChemAxon
Polarizability35.82 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Mass Spec (NIST)Download (2.96 KB)
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, PositiveNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, NegativeNot Available
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, NegativeNot Available
Taxonomy
DescriptionThis compound belongs to the class of organic compounds known as cinchona alkaloids. These are alkaloids structurally characterized by the presence of the cinchonan skeleton, which consists of a quinoline linked to an azabicyclo[2.2.2]octane moiety.
KingdomOrganic compounds
Super ClassAlkaloids and derivatives
ClassCinchona alkaloids
Sub ClassNot Available
Direct ParentCinchona alkaloids
Alternative Parents
Substituents
  • Cinchonan-skeleton
  • Hydroxyquinoline
  • Quinoline
  • Quinuclidine
  • Anisole
  • Aralkylamine
  • Alkyl aryl ether
  • Benzenoid
  • Pyridine
  • Piperidine
  • Heteroaromatic compound
  • Tertiary aliphatic amine
  • Tertiary amine
  • Secondary alcohol
  • 1,2-aminoalcohol
  • Azacycle
  • Organoheterocyclic compound
  • Ether
  • Hydrocarbon derivative
  • Aromatic alcohol
  • Organooxygen compound
  • Organonitrogen compound
  • Amine
  • Alcohol
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors

Targets

Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
inhibitor
General Function:
Voltage-gated sodium channel activity involved in sa node cell action potential
Specific Function:
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. This channel is respon...
Gene Name:
SCN5A
Uniprot ID:
Q14524
Molecular Weight:
226937.475 Da
References
  1. Stokoe KS, Thomas G, Goddard CA, Colledge WH, Grace AA, Huang CL: Effects of flecainide and quinidine on arrhythmogenic properties of Scn5a+/Delta murine hearts modelling long QT syndrome 3. J Physiol. 2007 Jan 1;578(Pt 1):69-84. Epub 2006 Oct 5. [PubMed:17023504 ]
  2. Itoh H, Shimizu M, Takata S, Mabuchi H, Imoto K: A novel missense mutation in the SCN5A gene associated with Brugada syndrome bidirectionally affecting blocking actions of antiarrhythmic drugs. J Cardiovasc Electrophysiol. 2005 May;16(5):486-93. [PubMed:15877619 ]
  3. Grant AO: Electrophysiological basis and genetics of Brugada syndrome. J Cardiovasc Electrophysiol. 2005 Sep;16 Suppl 1:S3-7. [PubMed:16138883 ]
  4. Napolitano C, Priori SG: Brugada syndrome. Orphanet J Rare Dis. 2006 Sep 14;1:35. [PubMed:16972995 ]
  5. Ohgo T, Okamura H, Noda T, Satomi K, Suyama K, Kurita T, Aihara N, Kamakura S, Ohe T, Shimizu W: Acute and chronic management in patients with Brugada syndrome associated with electrical storm of ventricular fibrillation. Heart Rhythm. 2007 Jun;4(6):695-700. Epub 2007 Feb 20. [PubMed:17556186 ]
  6. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  7. Sheets MF, Fozzard HA, Lipkind GM, Hanck DA: Sodium channel molecular conformations and antiarrhythmic drug affinity. Trends Cardiovasc Med. 2010 Jan;20(1):16-21. doi: 10.1016/j.tcm.2010.03.002. [PubMed:20685573 ]
  8. Tella SR, Goldberg SR: Monoamine transporter and sodium channel mechanisms in the rapid pressor response to cocaine. Pharmacol Biochem Behav. 1998 Feb;59(2):305-12. [PubMed:9476974 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium channel activity
Specific Function:
Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues (PubMed:15820677, PubMed:21653227). Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potass...
Gene Name:
KCNK1
Uniprot ID:
O00180
Molecular Weight:
38142.775 Da
References
  1. Lesage F, Guillemare E, Fink M, Duprat F, Lazdunski M, Romey G, Barhanin J: TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure. EMBO J. 1996 Mar 1;15(5):1004-11. [PubMed:8605869 ]
  2. Fink M, Duprat F, Lesage F, Reyes R, Romey G, Heurteaux C, Lazdunski M: Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel. EMBO J. 1996 Dec 16;15(24):6854-62. [PubMed:9003761 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Potassium ion leak channel activity
Specific Function:
Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions.
Gene Name:
KCNK6
Uniprot ID:
Q9Y257
Molecular Weight:
33746.8 Da
References
  1. Patel AJ, Maingret F, Magnone V, Fosset M, Lazdunski M, Honore E: TWIK-2, an inactivating 2P domain K+ channel. J Biol Chem. 2000 Sep 15;275(37):28722-30. [PubMed:10887187 ]
  2. Guerard NC, Traebert M, Suter W, Dumotier BM: Selective block of IKs plays a significant role in MAP triangulation induced by IKr block in isolated rabbit heart. J Pharmacol Toxicol Methods. 2008 Jul-Aug;58(1):32-40. doi: 10.1016/j.vascn.2008.05.129. Epub 2008 Jun 8. [PubMed:18582585 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
Specific Function:
Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoforms USO have no channel activity by themself, but modulates channel characteristics by forming heterotetramers with other isoforms which are r...
Gene Name:
KCNH2
Uniprot ID:
Q12809
Molecular Weight:
126653.52 Da
References
  1. Po SS, Wang DW, Yang IC, Johnson JP Jr, Nie L, Bennett PB: Modulation of HERG potassium channels by extracellular magnesium and quinidine. J Cardiovasc Pharmacol. 1999 Feb;33(2):181-5. [PubMed:10028924 ]
  2. Dong DL, Li Z, Wang HZ, Du ZM, Song WH, Yang BF: Acidification alters antiarrhythmic drug blockade of the ether-a-go-go-related Gene (HERG) Channels. Basic Clin Pharmacol Toxicol. 2004 May;94(5):209-12. [PubMed:15125690 ]
  3. Wolpert C, Schimpf R, Giustetto C, Antzelevitch C, Cordeiro J, Dumaine R, Brugada R, Hong K, Bauersfeld U, Gaita F, Borggrefe M: Further insights into the effect of quinidine in short QT syndrome caused by a mutation in HERG. J Cardiovasc Electrophysiol. 2005 Jan;16(1):54-8. [PubMed:15673388 ]
  4. Lin C, Ke X, Cvetanovic I, Ranade V, Somberg J: The influence of extracellular acidosis on the effect of IKr blockers. J Cardiovasc Pharmacol Ther. 2005 Mar;10(1):67-76. [PubMed:15821840 ]
  5. Lin C, Cvetanovic I, Ke X, Ranade V, Somberg J: A mechanism for the potential proarrhythmic effect of acidosis, bradycardia, and hypokalemia on the blockade of human ether-a-go-go-related gene (HERG) channels. Am J Ther. 2005 Jul-Aug;12(4):328-36. [PubMed:16041196 ]
  6. Guerard NC, Traebert M, Suter W, Dumotier BM: Selective block of IKs plays a significant role in MAP triangulation induced by IKr block in isolated rabbit heart. J Pharmacol Toxicol Methods. 2008 Jul-Aug;58(1):32-40. doi: 10.1016/j.vascn.2008.05.129. Epub 2008 Jun 8. [PubMed:18582585 ]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitorinducer
General Function:
Vitamin d3 25-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiot...
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular Weight:
57342.67 Da
References
  1. Ludwig E, Schmid J, Beschke K, Ebner T: Activation of human cytochrome P-450 3A4-catalyzed meloxicam 5'-methylhydroxylation by quinidine and hydroquinidine in vitro. J Pharmacol Exp Ther. 1999 Jul;290(1):1-8. [PubMed:10381752 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  3. Ekins S, Bravi G, Wikel JH, Wrighton SA: Three-dimensional-quantitative structure activity relationship analysis of cytochrome P-450 3A4 substrates. J Pharmacol Exp Ther. 1999 Oct;291(1):424-33. [PubMed:10490933 ]
  4. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Oxygen binding
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP3A7
Uniprot ID:
P24462
Molecular Weight:
57525.03 Da
References
  1. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.
Gene Name:
CYP2D6
Uniprot ID:
P10635
Molecular Weight:
55768.94 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. Drug Interactions: Cytochrome P450 Drug Interaction Table [Link]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N...
Gene Name:
CYP1A2
Uniprot ID:
P05177
Molecular Weight:
58293.76 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Gene Name:
CYP2E1
Uniprot ID:
P05181
Molecular Weight:
56848.42 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Vitamin d 24-hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Gene Name:
CYP1A1
Uniprot ID:
P04798
Molecular Weight:
58164.815 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
  2. van Montfoort JE, Hagenbuch B, Fattinger KE, Muller M, Groothuis GM, Meijer DK, Meier PJ: Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations. J Pharmacol Exp Ther. 1999 Oct;291(1):147-52. [PubMed:10490898 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.
Gene Name:
CYP2B6
Uniprot ID:
P20813
Molecular Weight:
56277.81 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrate
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme...
Gene Name:
CYP2C8
Uniprot ID:
P10632
Molecular Weight:
55824.275 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Steroid hydroxylase activity
Specific Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenyto...
Gene Name:
CYP2C9
Uniprot ID:
P11712
Molecular Weight:
55627.365 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]

Carriers

Kind
Protein
Organism
Human
Pharmacological action
unknown
General Function:
Not Available
Specific Function:
Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction.
Gene Name:
ORM1
Uniprot ID:
P02763
Molecular Weight:
23511.38 Da
References
  1. Li JH, Xu JQ, Cao XM, Ni L, Li Y, Zhuang YY, Gong JB: Influence of the ORM1 phenotypes on serum unbound concentration and protein binding of quinidine. Clin Chim Acta. 2002 Mar;317(1-2):85-92. [PubMed:11814462 ]
  2. McCollam PL, Crouch MA, Arnaud P: Caucasian versus African-American differences in orosomucoid: potential implications for therapy. Pharmacotherapy. 1998 May-Jun;18(3):620-6. [PubMed:9620113 ]

Transporters

Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Quaternary ammonium group transmembrane transporter activity
Specific Function:
Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridiniu...
Gene Name:
SLC22A2
Uniprot ID:
O15244
Molecular Weight:
62579.99 Da
References
  1. Urakami Y, Akazawa M, Saito H, Okuda M, Inui K: cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. J Am Soc Nephrol. 2002 Jul;13(7):1703-10. [PubMed:12089365 ]
  2. Arndt P, Volk C, Gorboulev V, Budiman T, Popp C, Ulzheimer-Teuber I, Akhoundova A, Koppatz S, Bamberg E, Nagel G, Koepsell H: Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1. Am J Physiol Renal Physiol. 2001 Sep;281(3):F454-68. [PubMed:11502595 ]
  3. Urakami Y, Okuda M, Masuda S, Saito H, Inui KI: Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs. J Pharmacol Exp Ther. 1998 Nov;287(2):800-5. [PubMed:9808712 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Secondary active organic cation transmembrane transporter activity
Specific Function:
Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine...
Gene Name:
SLC22A1
Uniprot ID:
O15245
Molecular Weight:
61153.345 Da
References
  1. van Montfoort JE, Muller M, Groothuis GM, Meijer DK, Koepsell H, Meier PJ: Comparison of "type I" and "type II" organic cation transport by organic cation transporters and organic anion-transporting polypeptides. J Pharmacol Exp Ther. 2001 Jul;298(1):110-5. [PubMed:11408531 ]
  2. Bednarczyk D, Ekins S, Wikel JH, Wright SH: Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1. Mol Pharmacol. 2003 Mar;63(3):489-98. [PubMed:12606755 ]
  3. Zhang L, Dresser MJ, Gray AT, Yost SC, Terashita S, Giacomini KM: Cloning and functional expression of a human liver organic cation transporter. Mol Pharmacol. 1997 Jun;51(6):913-21. [PubMed:9187257 ]
  4. Zhang L, Schaner ME, Giacomini KM: Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa). J Pharmacol Exp Ther. 1998 Jul;286(1):354-61. [PubMed:9655880 ]
  5. Zhang L, Gorset W, Dresser MJ, Giacomini KM: The interaction of n-tetraalkylammonium compounds with a human organic cation transporter, hOCT1. J Pharmacol Exp Ther. 1999 Mar;288(3):1192-8. [PubMed:10027858 ]
  6. Sandhu P, Lee W, Xu X, Leake BF, Yamazaki M, Stone JA, Lin JH, Pearson PG, Kim RB: Hepatic uptake of the novel antifungal agent caspofungin. Drug Metab Dispos. 2005 May;33(5):676-82. Epub 2005 Feb 16. [PubMed:15716364 ]
  7. Sinclair CJ, Chi KD, Subramanian V, Ward KL, Green RM: Functional expression of a high affinity mammalian hepatic choline/organic cation transporter. J Lipid Res. 2000 Nov;41(11):1841-8. [PubMed:11060354 ]
  8. Arndt P, Volk C, Gorboulev V, Budiman T, Popp C, Ulzheimer-Teuber I, Akhoundova A, Koppatz S, Bamberg E, Nagel G, Koepsell H: Interaction of cations, anions, and weak base quinine with rat renal cation transporter rOCT2 compared with rOCT1. Am J Physiol Renal Physiol. 2001 Sep;281(3):F454-68. [PubMed:11502595 ]
  9. Urakami Y, Okuda M, Masuda S, Saito H, Inui KI: Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs. J Pharmacol Exp Ther. 1998 Nov;287(2):800-5. [PubMed:9808712 ]
  10. Martel F, Vetter T, Russ H, Grundemann D, Azevedo I, Koepsell H, Schomig E: Transport of small organic cations in the rat liver. The role of the organic cation transporter OCT1. Naunyn Schmiedebergs Arch Pharmacol. 1996 Aug-Sep;354(3):320-6. [PubMed:8878062 ]
  11. Busch AE, Quester S, Ulzheimer JC, Gorboulev V, Akhoundova A, Waldegger S, Lang F, Koepsell H: Monoamine neurotransmitter transport mediated by the polyspecific cation transporter rOCT1. FEBS Lett. 1996 Oct 21;395(2-3):153-6. [PubMed:8898084 ]
  12. Busch AE, Quester S, Ulzheimer JC, Waldegger S, Gorboulev V, Arndt P, Lang F, Koepsell H: Electrogenic properties and substrate specificity of the polyspecific rat cation transporter rOCT1. J Biol Chem. 1996 Dec 20;271(51):32599-604. [PubMed:8955087 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Symporter activity
Specific Function:
Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.
Gene Name:
SLC22A5
Uniprot ID:
O76082
Molecular Weight:
62751.08 Da
References
  1. Ohashi R, Tamai I, Yabuuchi H, Nezu JI, Oku A, Sai Y, Shimane M, Tsuji A: Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84. [PubMed:10525100 ]
  2. Ohashi R, Tamai I, Nezu Ji J, Nikaido H, Hashimoto N, Oku A, Sai Y, Shimane M, Tsuji A: Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2. Mol Pharmacol. 2001 Feb;59(2):358-66. [PubMed:11160873 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Transporter activity
Specific Function:
Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
Gene Name:
ABCB11
Uniprot ID:
O95342
Molecular Weight:
146405.83 Da
References
  1. Wang EJ, Casciano CN, Clement RP, Johnson WW: Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharm Res. 2003 Apr;20(4):537-44. [PubMed:12739759 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
substrateinhibitor
General Function:
Xenobiotic-transporting atpase activity
Specific Function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular Weight:
141477.255 Da
References
  1. Choo EF, Leake B, Wandel C, Imamura H, Wood AJ, Wilkinson GR, Kim RB: Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes. Drug Metab Dispos. 2000 Jun;28(6):655-60. [PubMed:10820137 ]
  2. Gao J, Murase O, Schowen RL, Aube J, Borchardt RT: A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells. Pharm Res. 2001 Feb;18(2):171-6. [PubMed:11405287 ]
  3. Wang EJ, Casciano CN, Clement RP, Johnson WW: Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochem Biophys Res Commun. 2001 Nov 30;289(2):580-5. [PubMed:11716514 ]
  4. Tang F, Horie K, Borchardt RT: Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa? Pharm Res. 2002 Jun;19(6):765-72. [PubMed:12134945 ]
  5. Horie K, Tang F, Borchardt RT: Isolation and characterization of Caco-2 subclones expressing high levels of multidrug resistance protein efflux transporter. Pharm Res. 2003 Feb;20(2):161-8. [PubMed:12636153 ]
  6. Schwab D, Fischer H, Tabatabaei A, Poli S, Huwyler J: Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25. [PubMed:12699389 ]
  7. Weiss J, Dormann SM, Martin-Facklam M, Kerpen CJ, Ketabi-Kiyanvash N, Haefeli WE: Inhibition of P-glycoprotein by newer antidepressants. J Pharmacol Exp Ther. 2003 Apr;305(1):197-204. [PubMed:12649369 ]
  8. Tanigawara Y, Okamura N, Hirai M, Yasuhara M, Ueda K, Kioka N, Komano T, Hori R: Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1). J Pharmacol Exp Ther. 1992 Nov;263(2):840-5. [PubMed:1359120 ]
  9. Ito T, Yano I, Tanaka K, Inui KI: Transport of quinolone antibacterial drugs by human P-glycoprotein expressed in a kidney epithelial cell line, LLC-PK1. J Pharmacol Exp Ther. 1997 Aug;282(2):955-60. [PubMed:9262363 ]
  10. Kim RB, Fromm MF, Wandel C, Leake B, Wood AJ, Roden DM, Wilkinson GR: The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors. J Clin Invest. 1998 Jan 15;101(2):289-94. [PubMed:9435299 ]
  11. Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. [PubMed:14985103 ]
  12. Jutabha P, Wempe MF, Anzai N, Otomo J, Kadota T, Endou H: Xenopus laevis oocytes expressing human P-glycoprotein: probing trans- and cis-inhibitory effects on [3H]vinblastine and [3H]digoxin efflux. Pharmacol Res. 2010 Jan;61(1):76-84. doi: 10.1016/j.phrs.2009.07.002. Epub 2009 Jul 21. [PubMed:19631272 ]
  13. Dahan A, Amidon GL: Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting. Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G371-7. doi: 10.1152/ajpgi.00102.2009. Epub 2009 Jun 18. [PubMed:19541926 ]
  14. Dahan A, Sabit H, Amidon GL: The H2 receptor antagonist nizatidine is a P-glycoprotein substrate: characterization of its intestinal epithelial cell efflux transport. AAPS J. 2009 Jun;11(2):205-13. doi: 10.1208/s12248-009-9092-5. Epub 2009 Mar 25. [PubMed:19319690 ]
  15. Smith BJ, Doran AC, McLean S, Tingley FD 3rd, O'Neill BT, Kajiji SM: P-glycoprotein efflux at the blood-brain barrier mediates differences in brain disposition and pharmacodynamics between two structurally related neurokinin-1 receptor antagonists. J Pharmacol Exp Ther. 2001 Sep;298(3):1252-9. [PubMed:11504828 ]
  16. Adachi Y, Suzuki H, Sugiyama Y: Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8. [PubMed:11785684 ]
  17. Neuhoff S, Ungell AL, Zamora I, Artursson P: pH-dependent bidirectional transport of weakly basic drugs across Caco-2 monolayers: implications for drug-drug interactions. Pharm Res. 2003 Aug;20(8):1141-8. [PubMed:12948010 ]
  18. Troutman MD, Thakker DR: Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium. Pharm Res. 2003 Aug;20(8):1210-24. [PubMed:12948019 ]
  19. Faassen F, Vogel G, Spanings H, Vromans H: Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22. [PubMed:12954186 ]
  20. Fromm MF, Kim RB, Stein CM, Wilkinson GR, Roden DM: Inhibition of P-glycoprotein-mediated drug transport: A unifying mechanism to explain the interaction between digoxin and quinidine [seecomments]. Circulation. 1999 Feb 2;99(4):552-7. [PubMed:9927403 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin.
Gene Name:
SLCO1A2
Uniprot ID:
P46721
Molecular Weight:
74144.105 Da
References
  1. van Montfoort JE, Muller M, Groothuis GM, Meijer DK, Koepsell H, Meier PJ: Comparison of "type I" and "type II" organic cation transport by organic cation transporters and organic anion-transporting polypeptides. J Pharmacol Exp Ther. 2001 Jul;298(1):110-5. [PubMed:11408531 ]
  2. Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB: OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos. 1999 Aug;27(8):866-71. [PubMed:10421612 ]
  3. Shitara Y, Sugiyama D, Kusuhara H, Kato Y, Abe T, Meier PJ, Itoh T, Sugiyama Y: Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport. Pharm Res. 2002 Feb;19(2):147-53. [PubMed:11883641 ]
  4. van Montfoort JE, Hagenbuch B, Fattinger KE, Muller M, Groothuis GM, Meijer DK, Meier PJ: Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations. J Pharmacol Exp Ther. 1999 Oct;291(1):147-52. [PubMed:10490898 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA).
Gene Name:
SLC22A8
Uniprot ID:
Q8TCC7
Molecular Weight:
59855.585 Da
References
  1. Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, Endou H: Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86. [PubMed:11306713 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Organic anion transmembrane transporter activity
Specific Function:
Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Gene Name:
ABCC2
Uniprot ID:
Q92887
Molecular Weight:
174205.64 Da
References
  1. Tang F, Horie K, Borchardt RT: Are MDCK cells transfected with the human MRP2 gene a good model of the human intestinal mucosa? Pharm Res. 2002 Jun;19(6):773-9. [PubMed:12134946 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Symporter activity
Specific Function:
Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET).
Gene Name:
SLC22A4
Uniprot ID:
Q9H015
Molecular Weight:
62154.48 Da
References
  1. Yabuuchi H, Tamai I, Nezu J, Sakamoto K, Oku A, Shimane M, Sai Y, Tsuji A: Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. J Pharmacol Exp Ther. 1999 May;289(2):768-73. [PubMed:10215651 ]
Kind
Protein
Organism
Human
Pharmacological action
unknown
Actions
inhibitor
General Function:
Sodium-independent organic anion transmembrane transporter activity
Specific Function:
Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.
Gene Name:
SLCO1B1
Uniprot ID:
Q9Y6L6
Molecular Weight:
76447.99 Da
References
  1. Nozawa T, Tamai I, Sai Y, Nezu J, Tsuji A: Contribution of organic anion transporting polypeptide OATP-C to hepatic elimination of the opioid pentapeptide analogue [D-Ala2, D-Leu5]-enkephalin. J Pharm Pharmacol. 2003 Jul;55(7):1013-20. [PubMed:12906759 ]
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Drug created on June 13, 2005 07:24 / Updated on December 07, 2016 02:38