Abscess, Intra-Abdominal

Also known as: Intra-abdominal Abscess / Abdominal abscess NOS / Abdominal abscess

Drug	Drug Name	Drug Description
DB01331	Cefoxitin	Cefoxitin is a semi-synthetic, broad-spectrum cepha antibiotic for intravenous administration. It is derived from cephamycin C, which is produced by Streptomyces lactamdurans.
DB01190	Clindamycin	Clindamycin is a semisynthetic lincosamide antibiotic that has largely replaced lincomycin due to an improved side effect profile. Clindamycin inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits. It may be bacteriostatic or bactericidal depending on the organism and drug concentration.
DB00916	Metronidazole	A nitroimidazole used to treat amebiasis; vaginitis; trichomonas infections; giardiasis; anaerobic bacteria; and treponemal infections. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed).

Drug	Drug Name	Target	Type
DB01331	Cefoxitin	Penicillin-binding protein 1A	target
DB01331	Cefoxitin	Penicillin-binding protein 1B	target
DB01331	Cefoxitin	Peptidoglycan synthase FtsI	target
DB01331	Cefoxitin	D-alanyl-D-alanine carboxypeptidase DacA	target
DB01331	Cefoxitin	D-alanyl-D-alanine carboxypeptidase DacB	target
DB01331	Cefoxitin	D-alanyl-D-alanine carboxypeptidase DacC	target
DB01331	Cefoxitin	D-alanyl-D-alanine endopeptidase	target
DB01331	Cefoxitin	Beta-lactamase	enzyme
DB01331	Cefoxitin	Penicillin-binding protein 3	target
DB01331	Cefoxitin	Penicillin-binding protein 1b	target
DB01331	Cefoxitin	Penicillin-binding protein 2a	target
DB01331	Cefoxitin	Penicillin-binding protein 1A	target
DB01331	Cefoxitin	Penicillin-binding protein 2B	target
DB01190	Clindamycin	50S ribosomal protein L10	target
DB01190	Clindamycin	Cytochrome P450 3A4	enzyme
DB01190	Clindamycin	23S rRNA	target
DB00916	Metronidazole	Iron hydrogenase 1	target
DB00916	Metronidazole	DNA	target
DB00916	Metronidazole	Oxygen-insensitive NADPH nitroreductase	target
DB00916	Metronidazole	Cytochrome P450 2C9	enzyme
DB00916	Metronidazole	Cytochrome P450 3A4	enzyme
DB00916	Metronidazole	Cytochrome P450 2C8	enzyme
DB00916	Metronidazole	Lanosterol 14-alpha demethylase	target
DB00916	Metronidazole	UDP-glucuronosyltransferase 1-1	enzyme

Drug	Drug Name	Phase	Status	Count
DB00009	Alteplase	3	Suspended	1
DB01060	Amoxicillin	3	Terminated	1
DB00766	Clavulanic acid	3	Terminated	1
DB06211	Doripenem	3	Terminated	1
DB00760	Meropenem	3	Terminated	1
DB09153	Sodium Chloride	3	Suspended	1
DB00560	Tigecycline	4	Completed	1
DB00218	Moxifloxacin	Not Available	Completed	1