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Identification
NameCalcium Chloride
Accession NumberDB01164  (APRD00840)
TypeSmall Molecule
GroupsApproved
DescriptionCalcium chloride is an ionic compound of calcium and chlorine. It is highly soluble in water and it is deliquescent. It is a salt that is solid at room temperature, and it behaves as a typical ionic halide. It has several common applications such as brine for refrigeration plants, ice and dust control on roads, and in cement. It can be produced directly from limestone, but large amounts are also produced as a by-product of the Solvay process. Because of its hygroscopic nature, it must be kept in tightly-sealed containers. [Wikipedia]
Structure
Thumb
Synonyms
Calcium chloride anhydrous
Calcium chloride, anhydrous
calcium(2+) chloride
External IDs E-509 / INS NO.509 / INS-509
Product Ingredients
IngredientUNIICASInChI KeyDetails
Calcium chloride dihydrateM4I0D6VV5M 10035-04-8LLSDKQJKOVVTOJ-UHFFFAOYSA-LDetails
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
10% Calcium Chloride Injection USPSolution100 mgIntravenousHospira, Inc.1981-12-31Not applicableCanada
Calciject Inj 100mg/mlLiquid100 mgIntravenousOmega Laboratories Ltd1990-12-31Not applicableCanada
Calcium ChlorideInjection, solution100 mg/mLIntravenousGeneral Injectables & Vaccines2010-07-01Not applicableUs
Calcium ChlorideInjection, solution100 mg/mLIntravenousCardinal Health2011-03-09Not applicableUs
Calcium ChlorideInjection, solution100 mg/mLIntravenousHospira, Inc.2005-09-14Not applicableUs
Calcium Chloride Additive 0.13-4.5lPowder3.78 gHemodialysisHaemotec Inc.2006-12-012011-07-27Canada
Calcium Chloride Bp - Additive for Concentrated Haemodialysis SolutionsPowder3.78 gHemodialysisGenpharm Ulc1998-06-182004-07-30Canada
Calcium Chloride Bp - Additive for Concentrated Haemodialysis SolutionsPowder12.32 gHemodialysisGenpharm Ulc1998-06-182004-07-30Canada
Calcium Chloride for HaemodialysisPowder7.45 gHemodialysisChief Medical Supplies Ltd2013-03-26Not applicableCanada
Calcium Chloride Inj 10%Liquid100 mgIntravenousInternational Medication Systems, Limited1971-12-311997-08-15Canada
Calcium Chloride Injection 100mg/mlLiquid100 mgIntravenousAstra Zeneca1986-12-312004-11-15Canada
Calcium-35 0.25 - 10Powder, for solution12.9 gHemodialysisAlthin Biopharm Inc.1988-12-312001-08-27Canada
Calcium-35 0.25 - 4.5Powder, for solution5.8 gHemodialysisBaxter Laboratories1988-12-312002-08-01Canada
Calcium-36.8 0.25-4.5Powder6.1 gHemodialysisBaxter Laboratories1995-12-312004-08-05Canada
Calcium-36.8 0.5-4.5Powder12.2 gHemodialysisAlthin Biopharm Inc.1995-12-311999-09-23Canada
Calcium-45 0.25-4.5Powder7.45 gHemodialysisBaxter Laboratories1995-12-31Not applicableCanada
Calcium-45 0.5-4.5Powder14.9 gHemodialysisBaxter Laboratories1995-12-31Not applicableCanada
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Calcium ChlorideInjection, solution100 mg/mLIntravenous; IntraventricularCardinal Health1984-09-17Not applicableUs
Calcium ChlorideInjection, solution100 mg/mLIntravenous; IntraventricularHospira, Inc.1984-09-17Not applicableUs
Calcium ChlorideInjection100 mg/mLIntravenousCardinal Health2011-06-14Not applicableUs
Calcium ChlorideInjection, solution100 mg/mLIntravenousAmerican Regent1990-09-30Not applicableUs
Calcium ChlorideInjection100 mg/mLIntravenous; IntraventricularInternational Medication Systems, Limited1973-05-01Not applicableUs
Calcium ChlorideInjection100 mg/mLParenteralAmphastar Pharmaceuticals, Inc.2000-06-012016-12-07Us
Calcium ChlorideInjection100 mg/mLIntravenous; IntraventricularA S Medication Solutions1973-05-01Not applicableUs
Calcium ChlorideInjection, solution20 mg/mLIntravenousCantrell Drug Company2011-03-08Not applicableUs
Calcium ChlorideInjection, solution100 mg/mLIntravenous; IntraventricularGeneral Injectables & Vaccines2010-03-01Not applicableUs
Calcium ChlorideInjection, solution100 mg/mLIntravenousGeneral Injectables & Vaccines2010-03-012017-01-19Us
International Brands
NameCompany
JarcalNot Available
LiquiCal-D 400Not Available
Brand mixtures
NameLabellerIngredients
(40 Mmols/l) Potassium Chloride In Lactated Ringer's Injection USPBaxter Laboratories
Accusol 35 K0Chief Medical Supplies Ltd
Accusol 35 K2Chief Medical Supplies Ltd
Accusol 35 K4Chief Medical Supplies Ltd
Acid Concentrate D12028Althin Biopharm Inc.
Acid Concentrate D12054Althin Biopharm Inc.
Acid Concentrate D12092Althin Biopharm Inc.
Acid Concentrate D12093Baxter Laboratories
Acid Concentrate D12095Baxter Laboratories
Acid Concentrate D12119Althin Biopharm Inc.
Acid Concentrate D12132Althin Biopharm Inc.
Acid Concentrate D12150Althin Biopharm Inc.
Acid Concentrate D12247Althin Biopharm Inc.
Acid Concentrate D12250Althin Biopharm Inc.
Acid Concentrate D12261Althin Biopharm Inc.
Acid Concentrate D12268Althin Biopharm Inc.
Acid Concentrate (r04968)Genpharm Ulc
Acid Concentrate (r04969)Genpharm Ulc
Acid Concentrate (r04974)Genpharm Ulc
Acid Concentrate (r04975)Genpharm Ulc
Acid Concentrate (r04976)Genpharm Ulc
Acid Concentrate 2109Althin Biopharm Inc.
Acid Concentrate 2186Baxter Laboratories
Acid Concentrate 2189Baxter Laboratories
Acid Concentrate 2196Althin Biopharm Inc.
Acid Concentrate 2198Baxter Laboratories
Acid Concentrate Bp Rz267cGenpharm Ulc
Acid Concentrate D-18006Baxter Laboratories
Acid Concentrate D12091Althin Biopharm Inc.
Acid Concentrate D12249Althin Biopharm Inc.
Acid Concentrate D12251Althin Biopharm Inc.
Acid Concentrate D12252Althin Biopharm Inc.
Acid Concentrate D12292Baxter Laboratories
Acid Concentrate D12315Althin Biopharm Inc.
Acid Concentrate D18000Althin Biopharm Inc.
Acid Concentrate D18001Althin Biopharm Inc.
Acid Concentrate D18008Althin Biopharm Inc.
Acid Concentrate D18009Althin Biopharm Inc.
Acid Concentrate Ro4947Genpharm Ulc
Acid Concentrate Rx252cBdh Inc.
Acid Concentrate Rx253cBdh Inc.
Acid Concentrate Rz110cGenpharm Ulc
Acid Concentrate Rz144cGenpharm Ulc
Acid Concentrate Rz150cGenpharm Ulc
Acid Concentrate Rz211cGenpharm Ulc
Acid Concentrate Rz212cGenpharm Ulc
Acid Concentrate-r04948 LiqBdh Inc.
Acid Concentrate(36.83x) R04900Bdh Inc.
Acid Concentrate(36.83x) R04906Bdh Inc.
Acid Conentrate (r04930)Genpharm Ulc
Amo Endosol SolutionAmo Canada Company
Balanced SaltB. Braun Medical Inc.
Balanced Salt SolutionHospira, Inc.
Bicarb Hemodial Conc 36.83Bicarbolyte Corporation
Bicarbolyte Bicar Hemodialsis ConcBicarbolyte Corporation
Bicarbolyte Bicar Hemodialysis ConcBicarbolyte Corporation
BssAlcon, Inc.
Bss PlusAlcon, Inc.
CardioplegicBaxter Laboratories
Clinimix EBaxter Laboratories
Concentrated Haemodialysis Solution Bp-rz266cGenpharm Ulc
D-12043 Sol Conc Electrolyt Pour DialyBio Pharm, Inc.
D12006Bio Pharm, Inc.
D12046 Conc Electrolyte Renal DialysisBio Pharm, Inc.
Dianeal Pd109 Capd SolutionBaxter Laboratories
Dioptic's Balanced Salt SolutionDioptic Pharmaceuticals Inc
Elliott's Solution AHospira, Inc.
ExtranealBaxter Laboratories
EyestreamAlcon, Inc.
Haemosol H-250Haemotec Inc.
Haemosol H-251Haemotec Inc.
Haemosol H-252Haemotec Inc.
Hemosol Lg2Gambro Inc
Hemosol Lg4Gambro Inc
Hemosol LoGambro Inc
Hyperlyte CRB. Braun Medical Inc.
Hyperlyte CR Multi-electrolyte ConcentrateB. Braun Medical Inc.
Iocare Balanced Salt SolutionIolab Pharmaceuticals
K+36.8Baxter Laboratories
K2 Liq R04902Bdh Inc.
Lactated Ringer's InjectionHospira, Inc.
Lactated Ringer's Injection USPB. Braun Medical Inc.
Lactated Ringer's IrrigationHospira, Inc.
Lactated Ringer's Irrigation SolBaxter Laboratories
Lactated RingersB. Braun Medical Inc.
Lactated Ringers Inj USPBaxter Laboratories
Lactated Ringers IrrigationB. Braun Medical Inc.
Moi-stir Oral SwabsticksSolvay Pharma Inc
Moi-stir SpraySolvay Pharma Inc
Multiple Electrolyte Additive Liq Formula 1Baxter Laboratories
Naturalyte H-251Fresenius Medical Care Korea
Naturalyte H-252Fresenius Medical Care Korea
Nutrilyte IIAmerican Regent
Odan Balanced Salt SolutionOdan Laboratories Ltd
Phoxillum Bk4/2.5Baxter Laboratories
PlegisolHospira, Inc.
Potassium Chloride In Lactated Ringer's InjectionBaxter Laboratories
Prismasol 0Baxter Laboratories
Prismasol 2Baxter Laboratories
Prismasol 4Baxter Laboratories
QuixilOmrix Biopharmaceuticals Ltd
R04903 LiqBdh Inc.
R04909 LiqBdh Inc.
R04919 LiqBdh Inc.
R04922 LiqBdh Inc.
R04936 LiqBdh Inc.
R04945 LiqBdh Inc.
R04946 LiqBdh Inc.
R04972 LiqBdh Inc.
R04973 LiqBdh Inc.
Ringer's InjBaxter Laboratories
Ringer's Injection USPB. Braun Medical Inc.
RingersB. Braun Medical Inc.
Salivart AerAll Star Sales and Service Ltd.
Salivart Oral MoisturizerGebauer Company
Sb 1000Renal Systems, Division Of Minntech Corp.
Sb 1006Renal Systems, Division Of Minntech Corp.
Sb-110Renal Systems, Division Of Minntech Corp.
Sb-131Renal Systems, Division Of Minntech Corp.
Sb-132Renal Systems, Division Of Minntech Corp.
Selutrio 10Fresenius Medical Care Deutchland Gmbh
Selutrio 40Fresenius Medical Care Deutchland Gmbh
Tpn ElectrolytesHospira, Inc.
Vamin NFresenius Kabi Ab
Categories
UNIIOFM21057LP
CAS number10043-52-4
WeightAverage: 110.984
Monoisotopic: 109.900296569
Chemical FormulaCaCl2
InChI KeyUXVMQQNJUSDDNG-UHFFFAOYSA-L
InChI
InChI=1S/Ca.2ClH/h;2*1H/q+2;;/p-2
IUPAC Name
calcium dichloride
SMILES
[Cl-].[Cl-].[Ca++]
Pharmacology
IndicationFor the treatment of hypocalcemia in those conditions requiring a prompt increase in blood plasma calcium levels, for the treatment of magnesium intoxication due to overdosage of magnesium sulfate, and used to combat the deleterious effects of hyperkalemia as measured by electrocardiographic (ECG), pending correction of the increased potassium level in the extracellular fluid.
Structured Indications
PharmacodynamicsCalcium is the fifth most abundant element in the body and the major fraction is in the bony structure. Calcium plays important physiological roles, many of which are poorly understood. It is essential for the functional integrity of the nervous and muscular systems. It is necessary for normal cardiac function and is one of the factors that operates in the mechanisms involved in the coagulation of blood.
Mechanism of actionCalcium chloride in water dissociates to provide calcium (Ca2+) and chloride (Cl-) ions. They are normal constituents of the body fluids and are dependent on various physiological mechanisms for maintenance of balance between intake and output. For hyperkalemia, the influx of calcium helps restore the normal gradient between threshold potential and resting membrane potential.
Related Articles
AbsorptionNot Available
Volume of distributionNot Available
Protein bindingNot Available
Metabolism

Approximately 80% of body calcium is excreted in the feces as insoluble salts; urinary excretion accounts for the remaining 20%.

Route of eliminationApproximately 80% of body calcium is excreted in the feces as insoluble salts; urinary excretion accounts for the remaining 20%.
Half lifeNot Available
ClearanceNot Available
ToxicityToo rapid injection may produce lowering of blood pressure and cardiac syncope. Persistent hypercalcemia from overdosage of calcium is unlikely because of rapid excretion.
Affected organisms
  • Humans and other mammals
PathwaysNot Available
Pharmacogenomic Effects/ADRs Not Available
Interactions
Drug Interactions
DrugInteractionDrug group
AcetyldigitoxinCalcium Chloride may increase the arrhythmogenic activities of Acetyldigitoxin.Approved
Alendronic acidThe serum concentration of Alendronic acid can be decreased when it is combined with Calcium Chloride.Approved
AlfacalcidolThe risk or severity of adverse effects can be increased when Calcium Chloride is combined with Alfacalcidol.Approved, Nutraceutical
AmlodipineThe therapeutic efficacy of Amlodipine can be decreased when used in combination with Calcium Chloride.Approved
AmrinoneThe therapeutic efficacy of Amrinone can be decreased when used in combination with Calcium Chloride.Approved
AzelnidipineThe therapeutic efficacy of Azelnidipine can be decreased when used in combination with Calcium Chloride.Approved
AzimilideThe therapeutic efficacy of Azimilide can be decreased when used in combination with Calcium Chloride.Investigational
BarnidipineThe therapeutic efficacy of Barnidipine can be decreased when used in combination with Calcium Chloride.Approved
BendroflumethiazideBendroflumethiazide may decrease the excretion rate of Calcium Chloride which could result in a higher serum level.Approved
BenidipineThe therapeutic efficacy of Benidipine can be decreased when used in combination with Calcium Chloride.Approved
BepridilThe therapeutic efficacy of Bepridil can be decreased when used in combination with Calcium Chloride.Approved, Withdrawn
CalcidiolThe risk or severity of adverse effects can be increased when Calcium Chloride is combined with Calcidiol.Approved, Nutraceutical
CalcipotriolThe risk or severity of adverse effects can be increased when Calcium Chloride is combined with Calcipotriol.Approved
CalcitriolThe risk or severity of adverse effects can be increased when Calcium Chloride is combined with Calcitriol.Approved, Nutraceutical
Calcium AcetateThe risk or severity of adverse effects can be increased when Calcium Chloride is combined with Calcium Acetate.Approved
CeftriaxoneThe risk or severity of adverse effects can be increased when Calcium Chloride is combined with Ceftriaxone.Approved
ChlorothiazideChlorothiazide may decrease the excretion rate of Calcium Chloride which could result in a higher serum level.Approved, Vet Approved
ChlortetracyclineThe serum concentration of Chlortetracycline can be decreased when it is combined with Calcium Chloride.Approved, Vet Approved
ChlorthalidoneChlorthalidone may decrease the excretion rate of Calcium Chloride which could result in a higher serum level.Approved
CholecalciferolThe risk or severity of adverse effects can be increased when Calcium Chloride is combined with Cholecalciferol.Approved, Nutraceutical
CilnidipineThe therapeutic efficacy of Cilnidipine can be decreased when used in combination with Calcium Chloride.Approved
CinnarizineThe therapeutic efficacy of Cinnarizine can be decreased when used in combination with Calcium Chloride.Approved
CinoxacinCalcium Chloride can cause a decrease in the absorption of Cinoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Withdrawn
CiprofloxacinCalcium Chloride can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
ClevidipineThe therapeutic efficacy of Clevidipine can be decreased when used in combination with Calcium Chloride.Approved
ClodronateThe serum concentration of Clodronate can be decreased when it is combined with Calcium Chloride.Approved, Investigational, Vet Approved
DarodipineThe therapeutic efficacy of Darodipine can be decreased when used in combination with Calcium Chloride.Experimental
DeferiproneThe serum concentration of Deferiprone can be decreased when it is combined with Calcium Chloride.Approved
DemeclocyclineThe serum concentration of Demeclocycline can be decreased when it is combined with Calcium Chloride.Approved
DeslanosideCalcium Chloride may increase the arrhythmogenic activities of Deslanoside.Approved
DigitoxinCalcium Chloride may increase the arrhythmogenic activities of Digitoxin.Approved
DigoxinCalcium Chloride may increase the arrhythmogenic activities of Digoxin.Approved
DihydrotachysterolThe risk or severity of adverse effects can be increased when Calcium Chloride is combined with Dihydrotachysterol.Approved
DiltiazemThe therapeutic efficacy of Diltiazem can be decreased when used in combination with Calcium Chloride.Approved
Dipotassium phosphateCalcium Chloride can cause a decrease in the absorption of Dipotassium phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
DobutamineThe therapeutic efficacy of Dobutamine can be decreased when used in combination with Calcium Chloride.Approved
DolutegravirThe serum concentration of Dolutegravir can be decreased when it is combined with Calcium Chloride.Approved
DoxercalciferolThe risk or severity of adverse effects can be increased when Calcium Chloride is combined with Doxercalciferol.Approved
DoxycyclineThe serum concentration of Doxycycline can be decreased when it is combined with Calcium Chloride.Approved, Investigational, Vet Approved
EfonidipineThe therapeutic efficacy of Efonidipine can be decreased when used in combination with Calcium Chloride.Approved
EltrombopagThe serum concentration of Eltrombopag can be decreased when it is combined with Calcium Chloride.Approved
EnoxacinCalcium Chloride can cause a decrease in the absorption of Enoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
EperisoneThe therapeutic efficacy of Eperisone can be decreased when used in combination with Calcium Chloride.Approved, Investigational
ErgocalciferolThe risk or severity of adverse effects can be increased when Calcium Chloride is combined with Ergocalciferol.Approved, Nutraceutical
EstramustineCalcium Chloride can cause a decrease in the absorption of Estramustine resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Etidronic acidThe serum concentration of Etidronic acid can be decreased when it is combined with Calcium Chloride.Approved
FelodipineThe therapeutic efficacy of Felodipine can be decreased when used in combination with Calcium Chloride.Approved, Investigational
FendilineThe therapeutic efficacy of Fendiline can be decreased when used in combination with Calcium Chloride.Withdrawn
FleroxacinCalcium Chloride can cause a decrease in the absorption of Fleroxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
FlumequineCalcium Chloride can cause a decrease in the absorption of Flumequine resulting in a reduced serum concentration and potentially a decrease in efficacy.Withdrawn
FlunarizineThe therapeutic efficacy of Flunarizine can be decreased when used in combination with Calcium Chloride.Approved
GabapentinThe therapeutic efficacy of Gabapentin can be decreased when used in combination with Calcium Chloride.Approved, Investigational
GatifloxacinCalcium Chloride can cause a decrease in the absorption of Gatifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
GemifloxacinCalcium Chloride can cause a decrease in the absorption of Gemifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
GrepafloxacinCalcium Chloride can cause a decrease in the absorption of Grepafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Withdrawn
HydrochlorothiazideHydrochlorothiazide may decrease the excretion rate of Calcium Chloride which could result in a higher serum level.Approved, Vet Approved
HydroflumethiazideHydroflumethiazide may decrease the excretion rate of Calcium Chloride which could result in a higher serum level.Approved
IbandronateThe serum concentration of Ibandronate can be decreased when it is combined with Calcium Chloride.Approved, Investigational
IndapamideIndapamide may decrease the excretion rate of Calcium Chloride which could result in a higher serum level.Approved
IsradipineThe therapeutic efficacy of Isradipine can be decreased when used in combination with Calcium Chloride.Approved
LacidipineThe therapeutic efficacy of Lacidipine can be decreased when used in combination with Calcium Chloride.Approved
LamotrigineThe therapeutic efficacy of Lamotrigine can be decreased when used in combination with Calcium Chloride.Approved, Investigational
LercanidipineThe therapeutic efficacy of Lercanidipine can be decreased when used in combination with Calcium Chloride.Approved, Investigational
LevofloxacinCalcium Chloride can cause a decrease in the absorption of Levofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
LevothyroxineThe therapeutic efficacy of Levothyroxine can be decreased when used in combination with Calcium Chloride.Approved
LiothyronineThe therapeutic efficacy of Liothyronine can be decreased when used in combination with Calcium Chloride.Approved, Vet Approved
LiotrixThe therapeutic efficacy of Liotrix can be decreased when used in combination with Calcium Chloride.Approved
Lipoic AcidCalcium Chloride can cause a decrease in the absorption of Lipoic Acid resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Nutraceutical
LomefloxacinCalcium Chloride can cause a decrease in the absorption of Lomefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Magnesium SulfateThe therapeutic efficacy of Magnesium Sulfate can be decreased when used in combination with Calcium Chloride.Approved, Vet Approved
ManidipineThe therapeutic efficacy of Manidipine can be decreased when used in combination with Calcium Chloride.Approved
MethyclothiazideMethyclothiazide may decrease the excretion rate of Calcium Chloride which could result in a higher serum level.Approved
MetolazoneMetolazone may decrease the excretion rate of Calcium Chloride which could result in a higher serum level.Approved
MibefradilThe therapeutic efficacy of Mibefradil can be decreased when used in combination with Calcium Chloride.Withdrawn
MinocyclineThe serum concentration of Minocycline can be decreased when it is combined with Calcium Chloride.Approved, Investigational
MoxifloxacinCalcium Chloride can cause a decrease in the absorption of Moxifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Investigational
Nalidixic AcidCalcium Chloride can cause a decrease in the absorption of Nalidixic Acid resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
NicardipineThe therapeutic efficacy of Nicardipine can be decreased when used in combination with Calcium Chloride.Approved
NifedipineThe therapeutic efficacy of Nifedipine can be decreased when used in combination with Calcium Chloride.Approved
NiguldipineThe therapeutic efficacy of Niguldipine can be decreased when used in combination with Calcium Chloride.Experimental
NiludipineThe therapeutic efficacy of Niludipine can be decreased when used in combination with Calcium Chloride.Experimental
NilvadipineThe therapeutic efficacy of Nilvadipine can be decreased when used in combination with Calcium Chloride.Approved
NimesulideThe therapeutic efficacy of Nimesulide can be decreased when used in combination with Calcium Chloride.Approved, Withdrawn
NimodipineThe therapeutic efficacy of Nimodipine can be decreased when used in combination with Calcium Chloride.Approved
NisoldipineThe therapeutic efficacy of Nisoldipine can be decreased when used in combination with Calcium Chloride.Approved
NitrendipineThe therapeutic efficacy of Nitrendipine can be decreased when used in combination with Calcium Chloride.Approved
NorfloxacinCalcium Chloride can cause a decrease in the absorption of Norfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
OfloxacinCalcium Chloride can cause a decrease in the absorption of Ofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
OleandrinCalcium Chloride may increase the arrhythmogenic activities of Anvirzel.Experimental
OuabainCalcium Chloride may increase the arrhythmogenic activities of Ouabain.Approved
OxytetracyclineThe serum concentration of Oxytetracycline can be decreased when it is combined with Calcium Chloride.Approved, Vet Approved
PamidronateThe serum concentration of Pamidronate can be decreased when it is combined with Calcium Chloride.Approved
ParicalcitolThe risk or severity of adverse effects can be increased when Calcium Chloride is combined with Paricalcitol.Approved, Investigational
PefloxacinCalcium Chloride can cause a decrease in the absorption of Pefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
PerhexilineThe therapeutic efficacy of Perhexiline can be decreased when used in combination with Calcium Chloride.Approved
PinaveriumThe therapeutic efficacy of Pinaverium can be decreased when used in combination with Calcium Chloride.Approved
PolythiazidePolythiazide may decrease the excretion rate of Calcium Chloride which could result in a higher serum level.Approved
PregabalinThe therapeutic efficacy of Pregabalin can be decreased when used in combination with Calcium Chloride.Approved, Illicit, Investigational
PrenylamineThe therapeutic efficacy of Prenylamine can be decreased when used in combination with Calcium Chloride.Withdrawn
QuinethazoneQuinethazone may decrease the excretion rate of Calcium Chloride which could result in a higher serum level.Approved
RisedronateThe serum concentration of Risedronate can be decreased when it is combined with Calcium Chloride.Approved, Investigational
RosoxacinCalcium Chloride can cause a decrease in the absorption of Rosoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Sodium glycerophosphateCalcium Chloride can cause a decrease in the absorption of Sodium glycerophosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Sodium phosphatesCalcium Chloride can cause a decrease in the absorption of Sodium phosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
SparfloxacinCalcium Chloride can cause a decrease in the absorption of Sparfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved
Strontium ranelateThe serum concentration of Strontium ranelate can be decreased when it is combined with Calcium Chloride.Approved
Technetium Tc-99m MedronateThe serum concentration of Technetium Tc-99m Medronate can be decreased when it is combined with Calcium Chloride.Approved
TemafloxacinCalcium Chloride can cause a decrease in the absorption of Temafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Withdrawn
TetracyclineThe serum concentration of Tetracycline can be decreased when it is combined with Calcium Chloride.Approved, Vet Approved
Thyroid, porcineThe therapeutic efficacy of Thyroid, porcine can be decreased when used in combination with Calcium Chloride.Approved
Tiludronic acidThe serum concentration of Tiludronate can be decreased when it is combined with Calcium Chloride.Approved, Vet Approved
Tolfenamic AcidThe therapeutic efficacy of Tolfenamic Acid can be decreased when used in combination with Calcium Chloride.Approved
TranilastThe therapeutic efficacy of Tranilast can be decreased when used in combination with Calcium Chloride.Approved, Investigational
TrichlormethiazideTrichlormethiazide may decrease the excretion rate of Calcium Chloride which could result in a higher serum level.Approved, Vet Approved
TriethylenetetramineThe serum concentration of Triethylenetetramine can be decreased when it is combined with Calcium Chloride.Approved
TrovafloxacinCalcium Chloride can cause a decrease in the absorption of Trovafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.Approved, Withdrawn
VerapamilThe therapeutic efficacy of Verapamil can be decreased when used in combination with Calcium Chloride.Approved
XylometazolineThe therapeutic efficacy of Xylometazoline can be decreased when used in combination with Calcium Chloride.Approved
ZiconotideThe therapeutic efficacy of Ziconotide can be decreased when used in combination with Calcium Chloride.Approved
Zoledronic acidThe serum concentration of Zoledronic acid can be decreased when it is combined with Calcium Chloride.Approved
Food InteractionsNot Available
References
Synthesis Reference

Silvano Grosso, Kenneth E. Nelson, “Method for preparing liquid feed supplements containing calcium chloride.” U.S. Patent US3962484, issued August, 1973.

US3962484
General ReferencesNot Available
External Links
ATC CodesA12AA07B05XA07G04BA03
AHFS Codes
  • 40:12.00
  • 40:34.00*
  • 92:02.00*
PDB EntriesNot Available
FDA labelNot Available
MSDSDownload (74.1 KB)
Clinical Trials
Clinical Trials
PhaseStatusPurposeConditionsCount
1RecruitingTreatmentHead Neck Cancer1
1RecruitingTreatmentKeloids1
1, 2CompletedOtherGlaucoma1
1, 2CompletedTreatmentArterial hypoxia / Hypotension1
1, 2RecruitingPreventionAtherosclerosis1
2Active Not RecruitingTreatmentCardiopulmonary Bypass / Surgery, Cardiac1
2CompletedTreatmentAcidosis, Respiratory / Shock, Hemorrhagic / Traumatic Shock1
2CompletedTreatmentBlood Loss,Surgical / Carcinoma of the Prostate / General Surgery1
2CompletedTreatmentCataracts1
2CompletedTreatmentDysmenorrhea / Endometriosis1
2CompletedTreatmentSymptomatic Focal Vitreomacular Adhesion1
2RecruitingNot AvailablePain1
2RecruitingPreventionPancreaticoduodenectomy1
2TerminatedTreatmentCongestive Heart Failure (CHF)1
2, 3CompletedTreatmentGlaucoma1
3CompletedTreatmentCAPD / Diabetes / End Stage Renal Disease (ESRD)1
3CompletedTreatmentCataracts2
3CompletedTreatmentColon Cancer / Colon Polyps / Colorectal Polyps / Crohn's Disease (CD) / Diverticulitis / Rectal Cancers / Ulcerative Colitis (UC)1
3CompletedTreatmentDiabetes / ESRD1
3Unknown StatusTreatmentCongestive Heart Failure (CHF)1
4CompletedPreventionInflammatory processes1
4CompletedTreatmentAPD / CAPD / Diabetes / ESRD1
4CompletedTreatmentArthrocentesis / Pain / Temporomandibular Joint Dysfunction1
4RecruitingTreatmentRenal Insufficiency1
4TerminatedPreventionDiastolic Dysfunction1
4TerminatedTreatmentDepression / Depression, Myalgia1
4Unknown StatusTreatmentTraumas1
Not AvailableCompletedTreatmentCataracts1
Not AvailableEnrolling by InvitationTreatmentAnaesthesia therapy1
Not AvailableNot Yet RecruitingScreeningActual Impaired Fluid Volume1
Not AvailableNot Yet RecruitingTreatmentDiabetic Ketoacidosis1
Not AvailableNot Yet RecruitingTreatmentShock / Shock, Septic1
Not AvailableRecruitingTreatmentEnd Stage Renal Disease (ESRD)1
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
SolutionIntravenous100 mg
LiquidHemodialysis
SolutionHemodialysis
SolutionIntraocular
SolutionIrrigation
SolutionOphthalmic
Kit
LiquidIntravenous100 mg
InjectionIntravenous100 mg/mL
InjectionIntravenous; Intraventricular100 mg/mL
InjectionParenteral100 mg/mL
Injection, solutionIntravenous100 mg/mL
Injection, solutionIntravenous20 mg/mL
Injection, solutionIntravenous; Intraventricular100 mg/mL
PowderHemodialysis12.32 g
PowderHemodialysis3.78 g
Powder, for solutionHemodialysis12.9 g
Powder, for solutionHemodialysis5.8 g
PowderHemodialysis6.1 g
PowderHemodialysis12.2 g
PowderHemodialysis7.45 g
PowderHemodialysis14.9 g
SolutionIntra-arterial
SolutionOral
SolutionIntrathecal
Injection, solutionIntraperitoneal
SolutionIntraperitoneal
LiquidOphthalmic
Injection, solution, concentrateIntravenous
LiquidIntraocular
SolutionIntravenous
LiquidIrrigation
Injection, solutionIntravenous
LiquidBuccal
SprayBuccal
Injection, solutionIntra-arterial
SolutionHemodialysis; Intravenous
Kit; solutionTopical
LiquidIntravenous
InjectionIntravenous
IrrigantIrrigation
AerosolOral
Prices
Unit descriptionCostUnit
SureStep Test 25 Strip Box31.92USD box
Calcium chloride powder0.44USD g
Calcium chloride 10% vial0.18USD ml
Calcium chloride granules0.1USD g
Calcium chloride 10% ampul0.07USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6077836 No1997-06-202017-06-20Us
US6248726 No1998-06-192018-06-19Us
US7084130 No2001-11-292021-11-29Us
Properties
StateSolid
Experimental Properties
PropertyValueSource
melting point782 °CNot Available
water solubility0.745 g/mL (at 20 °C)Not Available
Predicted Properties
PropertyValueSource
logP-0.57ChemAxon
pKa (Strongest Acidic)-7ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9445
Blood Brain Barrier+0.975
Caco-2 permeable+0.6764
P-glycoprotein substrateNon-substrate0.9039
P-glycoprotein inhibitor INon-inhibitor0.9891
P-glycoprotein inhibitor IINon-inhibitor0.9866
Renal organic cation transporterNon-inhibitor0.9196
CYP450 2C9 substrateNon-substrate0.8116
CYP450 2D6 substrateNon-substrate0.717
CYP450 3A4 substrateNon-substrate0.7571
CYP450 1A2 substrateNon-inhibitor0.7506
CYP450 2C9 inhibitorNon-inhibitor0.8587
CYP450 2D6 inhibitorNon-inhibitor0.9306
CYP450 2C19 inhibitorNon-inhibitor0.8304
CYP450 3A4 inhibitorNon-inhibitor0.956
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9002
Ames testNon AMES toxic0.6808
CarcinogenicityCarcinogens 0.764
BiodegradationReady biodegradable0.6815
Rat acute toxicity1.9786 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9433
hERG inhibition (predictor II)Non-inhibitor0.9634
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397 )
Spectra
Mass Spec (NIST)Not Available
SpectraNot Available
Taxonomy
DescriptionThis compound belongs to the class of chemical entities known as alkaline earth metal chlorides. These are inorganic compounds in which the largest halogen atom is Chlorine, and the heaviest metal atom is a lanthanide.
KingdomChemical entities
Super ClassInorganic compounds
ClassMixed metal/non-metal compounds
Sub ClassAlkaline earth metal salts
Direct ParentAlkaline earth metal chlorides
Alternative Parents
Substituents
  • Alkaline earth metal chloride
  • Inorganic calcium salt
  • Inorganic chloride salt
  • Inorganic salt
Molecular FrameworkNot Available
External Descriptors
Comments
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Drug created on June 13, 2005 07:24 / Updated on April 29, 2017 04:37