Calcium Chloride

Identification

Name
Calcium Chloride
Accession Number
DB01164  (APRD00840)
Type
Small Molecule
Groups
Approved
Description

Calcium chloride is an ionic compound of calcium and chlorine. It is highly soluble in water and it is deliquescent. It is a salt that is solid at room temperature, and it behaves as a typical ionic halide. It has several common applications such as brine for refrigeration plants, ice and dust control on roads, and in cement. It can be produced directly from limestone, but large amounts are also produced as a by-product of the Solvay process. Because of its hygroscopic nature, it must be kept in tightly-sealed containers. [Wikipedia]

Structure
Thumb
Synonyms
  • Calcium chloride anhydrous
  • Calcium chloride, anhydrous
  • calcium(2+) chloride
External IDs
E-509 / INS NO.509 / INS-509
Product Ingredients
IngredientUNIICASInChI Key
Calcium chloride dihydrateM4I0D6VV5M10035-04-8LLSDKQJKOVVTOJ-UHFFFAOYSA-L
Active Moieties
NameKindUNIICASInChI Key
CalciumunknownSY7Q814VUP7440-70-2OYPRJOBELJOOCE-UHFFFAOYSA-N
Chloride ionionicQ32ZN4869816887-00-6VEXZGXHMUGYJMC-UHFFFAOYSA-M
Calcium cationionic2M83C4R6ZB14127-61-8BHPQYMZQTOCNFJ-UHFFFAOYSA-N
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Calciject Inj 100mg/mlLiquid100 mgIntravenousOmega Laboratories Ltd1990-12-31Not applicableCanada
Calcium ChlorideInjection, solution100 mg/1mLIntravenousHospira, Inc.2005-09-14Not applicableUs
Calcium ChlorideInjection, solution100 mg/1mLIntravenousCardinal Health2011-03-09Not applicableUs
Calcium ChlorideInjection, solution100 mg/1mLIntravenousGeneral Injectables & Vaccines2010-07-01Not applicableUs
Calcium ChlorideInjection, solution100 mg/1mLIntravenousMedical Purchasing Solutions, Llc2005-09-14Not applicableUs
Calcium Chloride Additive 0.13-4.5lPowder3.78 gHemodialysisHaemotec Inc.2006-12-012011-07-27Canada
Calcium Chloride Bp - Additive for Concentrated Haemodialysis SolutionsPowder12.32 gHemodialysisGenpharm Ulc1998-06-182004-07-30Canada
Calcium Chloride Bp - Additive for Concentrated Haemodialysis SolutionsPowder3.78 gHemodialysisGenpharm Ulc1998-06-182004-07-30Canada
Calcium Chloride for HaemodialysisPowder7.45 gHemodialysisChief Medical Supplies Ltd2013-03-26Not applicableCanada
Calcium Chloride Inj 10%Liquid100 mgIntravenousInternational Medication Systems, Limited1971-12-311997-08-15Canada
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Calcium ChlorideInjection, solution100 mg/1mLIntravenousAmerican Regent2018-02-06Not applicableUs
Calcium ChlorideInjection100 mg/1mLIntravenous; IntraventricularInternational Medication Systems, Limited2018-07-08Not applicableUs
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
(40 Mmols/l) Potassium Chloride In Lactated Ringer's Injection USPCalcium Chloride (20 mg) + Sodium lactate (310 mg) + Potassium Chloride (328 mg) + Sodium Chloride (600 mg)SolutionIntravenousBaxter Laboratories2002-12-112016-07-15Canada
5% Dextrose In Lactated Ringer's InjectionCalcium Chloride (20 mg) + Dextrose, unspecified form (5 g) + Sodium lactate (310 mg) + Potassium Chloride (30 mg) + Sodium Chloride (600 mg)SolutionIntravenousB. Braun Medical Inc.1993-12-31Not applicableCanada
Accusol 35 K0Calcium Chloride (0.343 g) + Magnesium chloride (0.136 g) + Sodium Chloride (7.66 g) + Sodium bicarbonate (12.9 g)SolutionHemodialysisChief Medical Supplies Ltd2007-10-31Not applicableCanada
Accusol 35 K2Calcium Chloride (0.343 g) + D-glucose (1.33 g) + Magnesium chloride (0.136 g) + Potassium Chloride (0.199 g) + Sodium Chloride (7.66 g) + Sodium bicarbonate (12.9 g)SolutionHemodialysisChief Medical Supplies LtdNot applicableNot applicableCanada
Accusol 35 K4Calcium Chloride (0.343 g) + D-glucose (1.33 g) + Magnesium chloride (0.136 g) + Potassium Chloride (0.398 g) + Sodium Chloride (7.66 g) + Sodium bicarbonate (12.9 g)SolutionHemodialysisChief Medical Supplies Ltd2007-10-31Not applicableCanada
Acetate Concentrate R07376Calcium Chloride (6.432 g) + Dextrose, unspecified form (38.5 g) + Magnesium chloride (3.558 g) + Potassium Chloride (2.609 g) + Sodium Chloride (204.5 g) + Sodium acetate (114.8 g)LiquidHemodialysisBdh Inc.1995-12-312000-08-03Canada
Acid Concentrate D12028Calcium Chloride (7.16 g) + Acetic acid (8.85 g) + Magnesium chloride (0.88 g) + Potassium Chloride (2.75 g) + Sodium Chloride (172 g)LiquidHemodialysisAlthin Biopharm Inc.1986-12-311997-08-13Canada
Acid Concentrate D12054Calcium Chloride (6.13 g) + Acetic acid (8.85 g) + Magnesium chloride (2.63 g) + Potassium Chloride (5.49 g) + Sodium Chloride (172.2 g)LiquidHemodialysisAlthin Biopharm Inc.1986-12-311997-08-13Canada
Acid Concentrate D12092Calcium Chloride (7.49 g) + Acetic acid (5.41 g) + Magnesium chloride (3.21 g) + Potassium Chloride (5.02 g) + Sodium Chloride (263 g)SolutionHemodialysisAlthin Biopharm Inc.1985-12-311998-08-27Canada
Acid Concentrate D12093Calcium Chloride (7.49 g) + Acetic acid (5.41 g) + Magnesium chloride (3.21 g) + Potassium Chloride (10.1 g) + Sodium Chloride (263 g)LiquidHemodialysisBaxter Laboratories1985-12-312002-08-01Canada
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Calcium ChlorideCalcium chloride dihydrate (100 mg/1mL)Injection, solutionIntravenous; IntraventricularHF Acquisition Co LLC, DBA HealthFirst2018-09-13Not applicableUs
Calcium ChlorideCalcium chloride dihydrate (100 mg/1mL)Injection, solutionIntravenous; IntraventricularHospira, Inc.2006-01-24Not applicableUs
Calcium ChlorideCalcium chloride dihydrate (100 mg/1mL)Injection, solutionIntravenous; IntraventricularGeneral Injectables & Vaccines2010-03-01Not applicableUs
Calcium ChlorideCalcium chloride dihydrate (100 mg/1mL)Injection, solutionIntravenous; IntraventricularCardinal Health1984-09-172019-04-30Us
Calcium ChlorideCalcium chloride dihydrate (100 mg/1mL)InjectionParenteralAmphastar Pharmaceuticals, Inc.1990-01-022009-12-31Us
Calcium ChlorideCalcium chloride dihydrate (100 mg/1mL)InjectionIntravenousCardinal Health2011-06-14Not applicableUs
Calcium ChlorideCalcium chloride dihydrate (100 mg/1mL)Injection, solutionIntravenousAMERICAN REGENT, INC.1990-09-302011-09-06Us
Calcium ChlorideCalcium chloride dihydrate (100 mg/1mL)Injection, solutionIntravenousGeneral Injectables & Vaccines2010-03-012014-02-01Us
Calcium ChlorideCalcium chloride dihydrate (100 mg/1mL)InjectionParenteralAmphastar Pharmaceuticals, Inc.1973-05-012009-12-31Us
Calcium ChlorideCalcium chloride dihydrate (20 mg/1mL)Injection, solutionIntravenousCantrell Drug Company2011-03-08Not applicableUs
International/Other Brands
Jarcal / LiquiCal-D 400
Categories
UNII
OFM21057LP
CAS number
10043-52-4
Weight
Average: 110.984
Monoisotopic: 109.900296569
Chemical Formula
CaCl2
InChI Key
UXVMQQNJUSDDNG-UHFFFAOYSA-L
InChI
InChI=1S/Ca.2ClH/h;2*1H/q+2;;/p-2
IUPAC Name
calcium dichloride
SMILES
[Cl-].[Cl-].[Ca++]

Pharmacology

Indication

For the treatment of hypocalcemia in those conditions requiring a prompt increase in blood plasma calcium levels, for the treatment of magnesium intoxication due to overdosage of magnesium sulfate, and used to combat the deleterious effects of hyperkalemia as measured by electrocardiographic (ECG), pending correction of the increased potassium level in the extracellular fluid.

Associated Conditions
Associated Therapies
Pharmacodynamics

Calcium is the fifth most abundant element in the body and the major fraction is in the bony structure. Calcium plays important physiological roles, many of which are poorly understood. It is essential for the functional integrity of the nervous and muscular systems. It is necessary for normal cardiac function and is one of the factors that operates in the mechanisms involved in the coagulation of blood.

Mechanism of action

Calcium chloride in water dissociates to provide calcium (Ca2+) and chloride (Cl-) ions. They are normal constituents of the body fluids and are dependent on various physiological mechanisms for maintenance of balance between intake and output. For hyperkalemia, the influx of calcium helps restore the normal gradient between threshold potential and resting membrane potential.

TargetActionsOrganism
UProtein S100-A13Not AvailableHuman
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism

Approximately 80% of body calcium is excreted in the feces as insoluble salts; urinary excretion accounts for the remaining 20%.

Route of elimination

Approximately 80% of body calcium is excreted in the feces as insoluble salts; urinary excretion accounts for the remaining 20%.

Half life
Not Available
Clearance
Not Available
Toxicity

Too rapid injection may produce lowering of blood pressure and cardiac syncope. Persistent hypercalcemia from overdosage of calcium is unlikely because of rapid excretion.

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
1alpha-Hydroxyvitamin D5The risk or severity of adverse effects can be increased when Calcium Chloride is combined with 1alpha-Hydroxyvitamin D5.
3-Aza-2,3-Dihydrogeranyl DiphosphateCalcium Chloride can cause a decrease in the absorption of 3-Aza-2,3-Dihydrogeranyl Diphosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.
3,5-diiodothyropropionic acidThe therapeutic efficacy of 3,5-diiodothyropropionic acid can be decreased when used in combination with Calcium Chloride.
AbaloparatideThe therapeutic efficacy of Abaloparatide can be decreased when used in combination with Calcium Chloride.
AcetyldigitoxinCalcium Chloride may increase the arrhythmogenic and cardiotoxic activities of Acetyldigitoxin.
AcetyldigoxinCalcium Chloride may increase the arrhythmogenic and cardiotoxic activities of Acetyldigoxin.
AgmatineThe therapeutic efficacy of Agmatine can be decreased when used in combination with Calcium Chloride.
Alendronic acidThe serum concentration of Alendronic acid can be decreased when it is combined with Calcium Chloride.
AlfacalcidolThe risk or severity of adverse effects can be increased when Calcium Chloride is combined with Alfacalcidol.
AmiodaroneThe therapeutic efficacy of Amiodarone can be decreased when used in combination with Calcium Chloride.
Food Interactions
Not Available

References

Synthesis Reference

Silvano Grosso, Kenneth E. Nelson, "Method for preparing liquid feed supplements containing calcium chloride." U.S. Patent US3962484, issued August, 1973.

US3962484
General References
Not Available
External Links
KEGG Compound
C08130
PubChem Compound
5284359
PubChem Substance
46507257
ChemSpider
23237
ChEBI
3312
ChEMBL
CHEMBL1200668
PharmGKB
PA448729
RxList
RxList Drug Page
Wikipedia
Calcium_chloride
ATC Codes
A12AA07 — Calcium chlorideA11GB01 — Ascorbic acid (vit c) and calciumB05XA07 — Calcium chlorideG04BA03 — Calcium chloride
AHFS Codes
  • 40:34.00* — Hemodialysis Solution
  • 40:12.00 — Replacement Preparations
MSDS
Download (74.1 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0RecruitingPreventionScleral Contact Lenses1
1RecruitingTreatmentHead Neck Cancer1
1RecruitingTreatmentKeloid Scars1
1, 2CompletedOtherGlaucoma1
1, 2CompletedTreatmentArterial Hypotension / Arterial hypoxia1
1, 2RecruitingPreventionAtherosclerosis1
2Active Not RecruitingTreatmentCardiopulmonary Bypass / Surgery, Cardiac1
2CompletedTreatmentAcidosis, Respiratory / Shock, Hemorrhagic / Traumatic Shock1
2CompletedTreatmentBlood Loss,Surgical / General Surgery / Prostate Cancer1
2CompletedTreatmentCataracts1
2CompletedTreatmentDysmenorrhea / Endometriosis1
2CompletedTreatmentSymptomatic Focal Vitreomacular Adhesion1
2RecruitingPreventionIntraoperative Complications1
2RecruitingPreventionPancreatoduodenectomy1
2TerminatedTreatmentCongestive Heart Failure (CHF)1
2, 3CompletedTreatmentGlaucoma1
3CompletedTreatmentCataracts2
3CompletedTreatmentChronic Lymphocytic Leukaemia (CLL)1
3CompletedTreatmentColon Polyps / Colorectal Polyps / Crohn's Disease (CD) / Diverticulitis / Malignant Neoplasm of Colon / Rectal Carcinoma / Ulcerative Colitis (UC)1
3CompletedTreatmentContinuous ambulatory peritoneal dialysis therapy / Diabetes Mellitus (DM) / End Stage Renal Disease (ESRD)1
3CompletedTreatmentDiabetes Mellitus (DM) / ESRD1
3CompletedTreatmentParents2
3Enrolling by InvitationTreatmentAnaesthesia therapy1
3Unknown StatusTreatmentCongestive Heart Failure (CHF)1
4CompletedPreventionInflammatory Reaction1
4CompletedTreatmentAPD / Continuous ambulatory peritoneal dialysis therapy / Diabetes Mellitus (DM) / ESRD1
4CompletedTreatmentArthrocentesis / Pain NOS / Temporomandibular Joint Dysfunction1
4CompletedTreatmentEmergency / Fluid Loss / Symptom Complex, Triple1
4CompletedTreatmentGlaucoma / Intraocular Pressure1
4RecruitingSupportive CareMalnutrition1
4RecruitingTreatmentImpaired Renal Function1
4RecruitingTreatmentKetoacidosis, Diabetic1
4TerminatedPreventionDiastolic Dysfunction1
4TerminatedTreatmentDepression / Depression, Myalgia1
4Unknown StatusTreatmentTraumas1
4WithdrawnTreatmentClostridium Difficile Infection (CDI)1
Not AvailableCompletedTreatmentCataracts1
Not AvailableNot Yet RecruitingScreeningActual Impaired Fluid Volume1
Not AvailableRecruitingNot AvailablePain NOS1
Not AvailableRecruitingTreatmentBiliary Atresia Intrahepatic Syndromic Form1
Not AvailableRecruitingTreatmentEnd Stage Renal Disease (ESRD)1
Not AvailableRecruitingTreatmentShock / Shock, Septic1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
  • American Regent
  • AstraZeneca Inc.
  • Baxter International Inc.
  • Cardinal Health
  • General Injectables and Vaccines Inc.
  • Hospira Inc.
  • J T Baker
  • Luitpold Pharmaceuticals Inc.
  • Physicians Total Care Inc.
  • Spectrum Pharmaceuticals
Dosage forms
FormRouteStrength
LiquidHemodialysis
Powder, for solutionIntraocular
SolutionIntraocular
SolutionIrrigation
Kit
Kit; solutionIntraocular
LiquidIntravenous100 mg
InjectionIntravenous100 mg/1mL
InjectionIntravenous; Intraventricular100 mg/1mL
InjectionParenteral100 mg/1mL
Injection, solutionIntravenous100 mg/1mL
Injection, solutionIntravenous20 mg/1mL
Injection, solutionIntravenous; Intraventricular100 mg/1mL
PowderHemodialysis12.32 g
PowderHemodialysis3.78 g
SolutionIntravenous100 mg
Powder, for solutionHemodialysis12.9 g
Powder, for solutionHemodialysis5.8 g
PowderHemodialysis6.1 g
PowderHemodialysis12.2 g
PowderHemodialysis7.45 g
PowderHemodialysis14.9 g
SolutionIntra-arterial
InjectionIntravenous
Injection, solutionIntraperitoneal
SolutionIntrathecal
InjectionIntrathecal
SolutionIntraperitoneal
SolutionOphthalmic
Injection, solution, concentrateIntravenous
LiquidIntraperitoneal
SolutionHemodialysis; Intraperitoneal
LiquidIntraocular
SolutionIntravenous
LiquidIrrigation
Solution, for slushIrrigation
LiquidBuccal
SprayBuccal
SolutionHemodialysis
Kit; solutionIntraocular; Irrigation
RinseDental
Injection, emulsionIntravenous
EmulsionIntravenous
Injection, solutionIntravenous
Injection, solutionIntra-arterial
Solution
LiquidIntravenous
SolutionHemodialysis; Intravenous
Kit; solutionTopical
IrrigantIrrigation
AerosolOral
Prices
Unit descriptionCostUnit
SureStep Test 25 Strip Box31.92USD box
Calcium chloride powder0.44USD g
Calcium chloride 10% vial0.18USD ml
Calcium chloride granules0.1USD g
Calcium chloride 10% ampul0.07USD ml
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6077836No1997-06-202017-06-20Us
US6248726No1998-06-192018-06-19Us
US7084130No2001-11-292021-11-29Us

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)782 °CNot Available
water solubility0.745 g/mL (at 20 °C)Not Available
Predicted Properties
PropertyValueSource
logP-0.57ChemAxon
pKa (Strongest Acidic)-7ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m3·mol-1ChemAxon
Polarizability1.78 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9445
Blood Brain Barrier+0.975
Caco-2 permeable+0.6764
P-glycoprotein substrateNon-substrate0.9039
P-glycoprotein inhibitor INon-inhibitor0.9891
P-glycoprotein inhibitor IINon-inhibitor0.9866
Renal organic cation transporterNon-inhibitor0.9196
CYP450 2C9 substrateNon-substrate0.8116
CYP450 2D6 substrateNon-substrate0.717
CYP450 3A4 substrateNon-substrate0.7571
CYP450 1A2 substrateNon-inhibitor0.7506
CYP450 2C9 inhibitorNon-inhibitor0.8587
CYP450 2D6 inhibitorNon-inhibitor0.9306
CYP450 2C19 inhibitorNon-inhibitor0.8304
CYP450 3A4 inhibitorNon-inhibitor0.956
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9002
Ames testNon AMES toxic0.6808
CarcinogenicityCarcinogens 0.764
BiodegradationReady biodegradable0.6815
Rat acute toxicity1.9786 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9433
hERG inhibition (predictor II)Non-inhibitor0.9634
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Description
This compound belongs to the class of inorganic compounds known as alkaline earth metal chlorides. These are inorganic compounds in which the largest halogen atom is Chlorine, and the heaviest metal atom is a lanthanide.
Kingdom
Inorganic compounds
Super Class
Mixed metal/non-metal compounds
Class
Alkaline earth metal salts
Sub Class
Alkaline earth metal chlorides
Direct Parent
Alkaline earth metal chlorides
Alternative Parents
Inorganic chloride salts / Inorganic calcium salts
Substituents
Alkaline earth metal chloride / Inorganic calcium salt / Inorganic chloride salt / Inorganic salt
Molecular Framework
Not Available
External Descriptors
inorganic chloride, calcium salt (CHEBI:3312)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Zinc ion binding
Specific Function
Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion doe...
Gene Name
S100A13
Uniprot ID
Q99584
Uniprot Name
Protein S100-A13
Molecular Weight
11471.095 Da
References
  1. Sivaraja V, Kumar TK, Rajalingam D, Graziani I, Prudovsky I, Yu C: Copper binding affinity of S100A13, a key component of the FGF-1 nonclassical copper-dependent release complex. Biophys J. 2006 Sep 1;91(5):1832-43. Epub 2006 Jun 9. [PubMed:16766622]

Drug created on June 13, 2005 07:24 / Updated on October 21, 2018 20:30