Ocular Irritation

Also known as: Ocular irritation / Eye irritation / Irritation eye / Irritation of eyes

DrugDrug NameDrug Description
DB09255DextranDextran is a polysaccharide that differs from others in that its glucose units are joined together 1:6 glucoside links. The main chain of glucose has short branches at frequent intervals which are probably joined by 1:3 and 1:4 glucoside links. The chains can be composed of about 200,000 glucose units.[A32011] Many bacteria, like _Leuconostoc_, can synthesize dextran from sucrose, and this activity is used commercially to obtain dextran.[T121] Dextran 40 is a sterile, nonpyrogenic preparation of low molecular weight dextran (average mol. wt. 40,000) in 5% Dextrose Injection or 0.9% Sodium Chloride Injection. It is administered by intravenous infusion. Dextran 75 is a complex branched glucan with an average molecular weight 75000 Daltons. It is produced from certain bacteria that with α-1,6 glycosidic linkages between glucose molecules and α-1,3 linkages between branches. When labelled with technetium Tc99m, dextran 75 is intravenously administered as an imaging agent to detect and diagnose conditions in the vascular compartment such as pericardial effusion or ventricular aneurysm.
DB09462GlycerinA trihydroxy sugar alcohol that is an intermediate in carbohydrate and lipid metabolism.
DB14543Hydrocortisone probutateNot Available
DB14545Hydrocortisone succinateNot Available
DB01839Propylene glycolA clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.
DB06764TetryzolineTetryzoline (also known as Tetrahydrozoline), a derivative of imidazoline, is found in over-the-counter eye drops and nasal sprays. Other derivatives include naphazoline, oxymetazoline, and xylometazoline. Johnson and Johnson manufactures tetryzoline eye drops under the brand Visine ®.
DB01593ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with anemia, short stature, hypogonadism, impaired wound healing, and geophagia. It is identified by the symbol _Zn_ [L2098]. A newer study suggests implies that an imbalance of zinc is associated with the neuronal damage associated with traumatic brain injury, stroke, and seizures [A32465]. Understanding the mechanisms that control brain zinc homeostasis is, therefore, imperative to the development of preventive and treatment regimens for these and other neurological disorders [A32465]. In addition to the above, recent review articles have already demonstrated the important role of zinc in the pathophysiology and treatment of affective disorders, plus discussed the potential value of zinc as a marker of these diseases [L2097]. Most recently, research has shown that polymorphism of the common polymorphism in zinc transporter _SLC30A8/ZnT8_ may increase susceptibility to type 2 diabetes provided novel insights into the role of zinc in diabetes [A32416].
DrugDrug NameTargetType
DB09462GlycerinHematopoietic prostaglandin D synthasetarget
DB09462GlycerinEndoglucanase Gtarget
DB09462GlycerinGlutathione S-transferase Ptarget
DB09462GlycerinGroup IIE secretory phospholipase A2target
DB09462GlycerinInositol-3-phosphate synthase 1target
DB09462GlycerinC4-dicarboxylate transport transcriptional regulatory protein DctDtarget
DB09462GlycerinAlcohol dehydrogenase 1Btarget
DB09462GlycerinInositol 1,4,5-trisphosphate receptor type 1target
DB09462GlycerinGlycodelintarget
DB09462GlycerinAlpha-N-acetylgalactosaminidasetarget
DB09462GlycerinCytochrome c4target
DB09462GlycerinBacterioferritintarget
DB09462GlycerinTGF-beta receptor type-2target
DB09462GlycerinArgininosuccinate synthasetarget
DB09462GlycerinEnolasetarget
DB09462GlycerinADP-ribosylation factor 1target
DB09462GlycerinMultidrug resistance protein MexAtarget
DB09462GlycerinBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1target
DB09462GlycerinHistidinol dehydrogenasetarget
DB09462GlycerinDNA mismatch repair protein MutLtarget
DB09462GlycerinGlycerol uptake facilitator proteintarget
DB09462GlycerinRibonucleoside-diphosphate reductase 1 subunit betatarget
DB09462GlycerinA/G-specific adenine glycosylasetarget
DB09462GlycerintRNA (cytosine(38)-C(5))-methyltransferasetarget
DB09462GlycerinCytochrome P450 2E1enzyme
DB09462GlycerinRetinal dehydrogenase 1enzyme
DB09462GlycerinPeroxisome proliferator-activated receptor deltatarget
DB14543Hydrocortisone probutateAnnexin A1target
DB14543Hydrocortisone probutateGlucocorticoid receptortarget
DB14543Hydrocortisone probutateSex hormone-binding globulincarrier
DB14543Hydrocortisone probutateCytochrome P450 3A4enzyme
DB14543Hydrocortisone probutateCytochrome P450 3A5enzyme
DB14543Hydrocortisone probutateCytochrome P450 3A7enzyme
DB14543Hydrocortisone probutateP-glycoprotein 1transporter
DB14543Hydrocortisone probutateSolute carrier organic anion transporter family member 1A2transporter
DB14543Hydrocortisone probutateATP-binding cassette sub-family G member 2transporter
DB14543Hydrocortisone probutateCytochrome P450 11B1, mitochondrialenzyme
DB14543Hydrocortisone probutateCytochrome P450 11B2, mitochondrialenzyme
DB14543Hydrocortisone probutateCytochrome P450 2C8enzyme
DB14543Hydrocortisone probutateCorticosteroid-binding globulincarrier
DB14543Hydrocortisone probutateCorticosteroid 11-beta-dehydrogenase isozyme 2target
DB14543Hydrocortisone probutate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
DB14543Hydrocortisone probutateSolute carrier family 22 member 8transporter
DB14545Hydrocortisone succinateCytochrome P450 3A4enzyme
DB14545Hydrocortisone succinateCytochrome P450 2C8enzyme
DB14545Hydrocortisone succinateCytochrome P450 11B1, mitochondrialenzyme
DB14545Hydrocortisone succinateCytochrome P450 11B2, mitochondrialenzyme
DB01839Propylene glycolCoagulation factor XIII A chaintarget
DB01839Propylene glycolHaloalkane dehalogenasetarget
DB01839Propylene glycolClavaminate synthase 1target
DB01839Propylene glycolLactaldehyde reductasetarget
DB01839Propylene glycolB12-independent glycerol dehydratasetarget
DB06764TetryzolineAlpha-1A adrenergic receptortarget
DB01593ZincB1 bradykinin receptortarget
DB01593ZincMethylated-DNA--protein-cysteine methyltransferasetarget
DB01593ZincFructose-bisphosphate aldolase Atarget
DB01593ZincElongation factor 1-alpha 1target
DB01593ZincAlpha-enolasetarget
DB01593ZincGlyceraldehyde-3-phosphate dehydrogenase, testis-specifictarget
DB01593ZincNucleoside diphosphate kinase Atarget
DB01593ZincProtein disulfide-isomerasetarget
DB01593ZincProtein disulfide-isomerase A3target
DB01593ZincPeroxiredoxin-1target
DB01593ZincPhosphoserine phosphatasetarget
DB01593ZincTriosephosphate isomerasetarget
DB01593ZincElongation factor Tu, mitochondrialtarget
DB01593ZincEstrogen receptor alphatarget
DB01593ZincInterleukin-3target
DB01593ZincMetallothionein-2target
DB01593ZincCopper chaperone for superoxide dismutasetarget
DB01593ZincHistone deacetylase 1target
DB01593ZincHistone deacetylase 4target
DB01593ZincDNA-3-methyladenine glycosylasetarget
DB01593ZincSemenogelin-1target
DB01593ZincSuperoxide dismutase [Cu-Zn]target
DB01593ZincHistone deacetylase 8target
DB01593ZincApoptosis regulatory protein Sivatarget
DB01593ZincGlycine receptor subunit alpha-1target
DB01593ZincE3 ubiquitin-protein ligase Mdm2target
DB01593ZincInsulintarget
DB01593ZincUtrophintarget
DB01593ZincAspartoacylasetarget
DB01593ZincProtein S100-A8target
DB01593ZincProtein S100-A9target
DB01593ZincMatrix metalloproteinase-9target
DB01593ZincTumor protein p73target
DB01593ZincProtein S100-A2target
DB01593ZincCellular tumor antigen p53target
DB01593ZincMetallothionein-3target
DB01593ZincProgrammed cell death protein 6target
DB01593ZincDAN domain family member 5target
DB01593ZincMetallothionein-1Atarget
DB01593ZincAlpha-1B-glycoproteintarget
DB01593ZincAlpha-2-macroglobulintarget
DB01593ZincAngiotensinogentarget
DB01593ZincAlpha-2-HS-glycoproteintarget
DB01593ZincSerum amyloid P-componenttarget
DB01593ZincApolipoprotein A-Itarget
DB01593ZincApolipoprotein A-IItarget
DB01593ZincApolipoprotein A-IVtarget
DB01593ZincApolipoprotein B receptortarget
DB01593ZincApolipoprotein Etarget
DB01593ZincApolipoprotein L1target
DB01593ZincComplement C1q subcomponent subunit Btarget
DB01593ZincComplement C1q subcomponent subunit Ctarget
DB01593ZincComplement C1r subcomponenttarget
DB01593ZincComplement C1s subcomponenttarget
DB01593ZincComplement C3target
DB01593ZincComplement C4-Btarget
DB01593ZincC4b-binding protein alpha chaintarget
DB01593ZincC4b-binding protein beta chaintarget
DB01593ZincComplement C5target
DB01593ZincLys-63-specific deubiquitinase BRCC36target
DB01593ZincComplement component C8 alpha chaintarget
DB01593ZincComplement component C8 beta chaintarget
DB01593ZincComplement component C8 gamma chaintarget
DB01593ZincComplement factor Btarget
DB01593ZincComplement factor Htarget
DB01593ZincComplement factor Itarget
DB01593ZincClusterintarget
DB01593ZincCeruloplasmintarget
DB01593ZincCarboxypeptidase N catalytic chaintarget
DB01593ZincCarboxypeptidase N subunit 2target
DB01593ZincDermcidintarget
DB01593ZincDesmoplakintarget
DB01593ZincCoagulation factor XIItarget
DB01593ZincCoagulation factor XIII B chaintarget
DB01593ZincProthrombintarget
DB01593ZincFicolin-3target
DB01593ZincFibrinogen alpha chaintarget
DB01593ZincFibronectintarget
DB01593ZincGelsolintarget
DB01593ZincHemoglobin subunit alphatarget
DB01593ZincHemoglobin subunit betatarget
DB01593ZincHaptoglobin-related proteintarget
DB01593ZincHornerintarget
DB01593ZincInsulin-like growth factor-binding protein complex acid labile subunittarget
DB01593ZincIg alpha-1 chain C regiontarget
DB01593ZincIg mu chain C regiontarget
DB01593ZincImmunoglobulin kappa variable 1-17target
DB01593ZincIg kappa chain V-III region GOLtarget
DB01593ZincImmunoglobulin lambda variable 3-21target
DB01593ZincInter-alpha-trypsin inhibitor heavy chain H1target
DB01593ZincInter-alpha-trypsin inhibitor heavy chain H2target
DB01593ZincInter-alpha-trypsin inhibitor heavy chain H3target
DB01593ZincInter-alpha-trypsin inhibitor heavy chain H4target
DB01593ZincImmunoglobulin J chaintarget
DB01593ZincJunction plakoglobintarget
DB01593ZincPlasma kallikreintarget
DB01593ZincKininogen-1target
DB01593ZincKeratin, type II cytoskeletal 1target
DB01593ZincKeratin, type I cytoskeletal 10target
DB01593ZincKeratin, type I cytoskeletal 14target
DB01593ZincKeratin, type I cytoskeletal 16target
DB01593ZincKeratin, type II cytoskeletal 2 epidermaltarget
DB01593ZincKeratin, type II cytoskeletal 5target
DB01593ZincKeratin, type II cytoskeletal 6Atarget
DB01593ZincKeratin, type I cytoskeletal 9target
DB01593ZincAlpha-1-acid glycoprotein 2target
DB01593ZincN-acetylmuramoyl-L-alanine amidasetarget
DB01593ZincSerum paraoxonase/arylesterase 1target
DB01593ZincPregnancy zone proteintarget
DB01593ZincProtein S100-A7target
DB01593ZincSelenoprotein Ptarget
DB01593ZincAlpha-1-antitrypsintarget
DB01593ZincAlpha-1-antichymotrypsintarget
DB01593ZincKallistatintarget
DB01593ZincCorticosteroid-binding globulintarget
DB01593ZincHeparin cofactor 2target
DB01593ZincSex hormone-binding globulintarget
DB01593ZincSerotransferrintarget
DB01593ZincTransthyretintarget
DB01593ZincVitronectintarget
DB01593ZincAmyloid-like protein 1target
DB01593ZincAmyloid-like protein 2target
DB01593ZincAmyloid beta A4 proteintarget
DB01593ZincPoly [ADP-ribose] polymerase 1target
DB01593ZincCarbonic anhydrase 1enzyme
DrugDrug NamePhaseStatusCount
DB00654LatanoprostNot AvailableCompleted1