Nonmetastatic Castration-Resistant Prostate Cancer

Also known as: Non-mestatatic castrate-resistant prostate cancer / Castration resistant, nonmetastatic Prostate Cancer / Non-metastatic, castration-resistant prostate cancer / Non-Metastatic Castration-Resistant Prostate Cancer

Drug	Drug Name	Drug Description
DB11901	Apalutamide	An androgen receptor inhibitor used to treat non-metastatic castration-resistant and metastatic castration-sensitive prostate cancer.
DB12941	Darolutamide	An androgen receptor antagonist used for castration-resistant, non-metastatic prostate cancer and metastatic hormone-sensitive prostate cancer.

Drug	Drug Name	Target	Type
DB11901	Apalutamide	Androgen receptor	target
DB11901	Apalutamide	Cytochrome P450 3A4	enzyme
DB11901	Apalutamide	Cytochrome P450 2C8	enzyme
DB11901	Apalutamide	Cytochrome P450 2C19	enzyme
DB11901	Apalutamide	Cytochrome P450 2C9	enzyme
DB11901	Apalutamide	P-glycoprotein 1	transporter
DB11901	Apalutamide	ATP-binding cassette sub-family G member 2	transporter
DB11901	Apalutamide	Solute carrier organic anion transporter family member 1B1	transporter
DB11901	Apalutamide	Solute carrier family 22 member 2	transporter
DB11901	Apalutamide	Solute carrier family 22 member 8	transporter
DB11901	Apalutamide	Multidrug and toxin extrusion protein 2	transporter
DB11901	Apalutamide	GABA(A) Receptor	target
DB11901	Apalutamide	Multidrug and toxin extrusion protein 1	transporter
DB11901	Apalutamide	Serum albumin	carrier
DB12941	Darolutamide	Cytochrome P450 3A4	enzyme
DB12941	Darolutamide	UDP-glucuronosyltransferase 1-9	enzyme
DB12941	Darolutamide	Androgen receptor	target
DB12941	Darolutamide	ATP-binding cassette sub-family G member 2	transporter
DB12941	Darolutamide	P-glycoprotein 1	transporter
DB12941	Darolutamide	Serum albumin	carrier
DB12941	Darolutamide	Progesterone receptor	target
DB12941	Darolutamide	Solute carrier organic anion transporter family member 1B1	transporter
DB12941	Darolutamide	Solute carrier organic anion transporter family member 1B3	transporter

Drug	Drug Name	Phase	Status	Count
DB05812	Abiraterone	1	Recruiting	1
DB11901	Apalutamide	1	Recruiting	1
DB01248	Docetaxel	1	Recruiting	1
DB00959	Methylprednisolone	1	Recruiting	1
DB00635	Prednisone	1	Recruiting	1
DB11853	Relugolix	1	Recruiting	1
DB05094	Enzalutamide	3	Active Not Recruiting	1
DB08899	Enzalutamide	3	Active Not Recruiting	1
DB12941	Darolutamide	4	Recruiting	1
DB11901	Apalutamide	Not Available	Active Not Recruiting	1
DB11901	Apalutamide	Not Available	Completed	2
DB12941	Darolutamide	Not Available	Active Not Recruiting	1
DB12941	Darolutamide	Not Available	Completed	2
DB12941	Darolutamide	Not Available	Not Yet Recruiting	1
DB08899	Enzalutamide	Not Available	Active Not Recruiting	1
DB08899	Enzalutamide	Not Available	Completed	2