Identification

Name
Methylprednisolone
Accession Number
DB00959  (APRD00342)
Type
Small Molecule
Groups
Approved, Vet approved
Description

A prednisolone derivative with similar anti-inflammatory action.

Structure
Thumb
Synonyms
  • (6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione
  • 1-dehydro-6α-methylhydrocortisone
  • 6α-methyl-11β,17α,21-triol-1,4-pregnadiene-3,20-dione
  • delta(1)-6alpha-Methylhydrocortisone
  • Methylprednisolon
  • Methylprednisolone
  • Methylprednisolonum
  • Metilprednisolona
External IDs
J3.872E / NSC-19987
Product Ingredients
IngredientUNIICASInChI Key
Methylprednisolone acetate43502P7F0P53-36-1PLBHSZGDDKCEHR-LFYFAGGJSA-N
Product Images
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Depo-MedrolInjection, suspension80 mg/1mLIntralesional; Intramuscular; Intrasynovial; Soft tissueRemedy Repack2014-09-11Not applicableUs
Depo-MedrolInjection, suspension40 mg/1mLIntralesional; Intramuscular; Intrasynovial; Soft tissuePharmacia and Upjohn Company LLC1959-05-28Not applicableUs
Depo-MedrolInjection, suspension40 mg/1mLIntra-articular; Intralesional; Intramuscular; Soft tissueRemedy Repack2017-05-10Not applicableUs
Depo-MedrolInjection, suspension80 mg/1mLIntralesional; Intramuscular; Intrasynovial; Soft tissueA-S Medication Solutions1959-05-28Not applicableUs
Depo-MedrolInjection, suspension40 mg/1mLIntra-articular; Intralesional; Intramuscular; Soft tissuePhysicians Total Care, Inc.2005-05-032012-06-30Us
Depo-MedrolInjection, suspension40 mg/1mLIntralesional; Intramuscular; Intrasynovial; Soft tissueA-S Medication Solutions1959-05-28Not applicableUs
Depo-MedrolInjection, suspension40 mg/1mLIntra-articular; Intralesional; Intramuscular; Soft tissueCardinal Health1959-05-28Not applicableUs
Depo-MedrolInjection, suspension40 mg/1mLIntra-articular; Intralesional; Intramuscular; Soft tissueA-S Medication Solutions1959-05-28Not applicableUs
Depo-MedrolInjection, suspension80 mg/1mLIntra-articular; Intralesional; Intramuscular; Soft tissuePharmacia and Upjohn Company LLC1959-05-28Not applicableUs
Depo-MedrolInjection, suspension40 mg/1mLIntra-articular; Intralesional; Intramuscular; Soft tissueRemedy Repack2016-06-152017-02-24Us
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
medPREDkit PlusKit4 mg/1Medarbor Llc2018-01-242018-02-20Us
MethylprednisoloneTablet4 mg/1OralA-S Medication Solutions2018-05-01Not applicableUs
MethylprednisoloneTablet4 mg/1OralUnit Dose Services1997-10-31Not applicableUs70786 000120180907 15195 1e4i2kx
MethylprednisoloneTablet4 mg/1OralUnit Dose Services1997-10-31Not applicableUs50436 403720180907 15195 1sd5jov
MethylprednisoloneTablet4 mg/1OralRebel Distributors1997-10-31Not applicableUs
MethylprednisoloneTablet8 mg/1OralGreenstone LLC2013-03-25Not applicableUs59762 004920180913 8702 u4ihwx
MethylprednisoloneTablet16 mg/1OralJubilant Cadista Pharmaceuticals Inc.1997-10-31Not applicableUs
MethylprednisoloneTablet4 mg/1OralTianjin Tianyao Pharmaceuticals Co., Ltd.2018-05-14Not applicableUs
MethylprednisoloneTablet8 mg/1OralCadila Pharnmaceuticals2018-05-01Not applicableUs
MethylprednisoloneTablet4 mg/1OralPhysicians Total Care, Inc.1994-11-29Not applicableUs
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Depo-medrol With LidocaineMethylprednisolone acetate (40 mg) + Lidocaine hydrochloride (10 mg)SolutionIntra-articular; IntrabursalPfizer1973-12-31Not applicableCanada
Lido-mp40Methylprednisolone acetate (40 mg/1mL) + Lidocaine hydrochloride (10 mg/1mL)KitInfiltration; Intra-articular; Intralesional; Intramuscular; Soft tissueBurke Therapeutics, LLC2015-06-182015-09-14Us
medPREDkitMethylprednisolone (4 mg/1) + Omeprazole (20 mg/1) + Sodium bicarbonate (1100 mg/1)KitMedarbor Llc2017-12-252018-01-15Us
Medrol Acne LotionMethylprednisolone acetate (2.5 mg) + Aluminum chlorohydrate (100 mg) + Octasulfur (50 mg)LotionTopicalPfizer1973-12-312014-04-04Canada
Methylprednisolone Sodium Succinate for Injection, USPMethylprednisolone (500 mg) + Water (10 ml)Powder, for solutionIntramuscular; IntravenousHospira, Inc.1998-03-12Not applicableCanada
Methylprednisolone Sodium Succinate for Injection, USPMethylprednisolone (1 g) + Water (20 ml)Powder, for solutionIntramuscular; IntravenousHospira, Inc.1998-03-12Not applicableCanada
Multi-Specialty KitMethylprednisolone acetate (40 mg/1mL) + Isopropyl Alcohol (70 mL/100mL) + Lidocaine hydrochloride (10 mg/1mL)KitProficient Rx LP2014-02-06Not applicableUs
Neo-medrolMethylprednisolone acetate (2.5 mg) + Neomycin sulfate (5 mg)CreamTopicalPfizer1960-12-312006-08-02Canada
Neo-medrol Acne LotionMethylprednisolone acetate (2.5 mg) + Aluminum chlorohydrate (100 mg) + Neomycin sulfate (2.5 mg) + Octasulfur (50 mg)LotionTopicalPfizer1965-12-31Not applicableCanada
P-Care D40Methylprednisolone acetate (40 mg/1mL) + Isopropyl Alcohol (0.7 mL/1mL) + Povidone-iodine (10 mg/1mL)KitRX PHARMA-PACK, INC.2017-06-16Not applicableUs
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Dyural 40 KitMethylprednisolone acetate (40 mg/1mL) + Bupivacaine hydrochloride monohydrate (2.5 mg/1mL) + Isopropyl Alcohol (70 mL/100mL) + Lidocaine hydrochloride (10 mg/1mL) + Povidone-iodine (10 mg/1mL)KitEpidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue; Subcutaneous; TopicalAsclemed Usa, Inc.2014-07-25Not applicableUs
Dyural 80 KitMethylprednisolone acetate (80 mg/1mL) + Bupivacaine hydrochloride monohydrate (2.5 mg/1mL) + Isopropyl Alcohol (70 mL/100mL) + Lidocaine hydrochloride (10 mg/1mL) + Povidone-iodine (10 mg/1mL)KitEpidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue; Subcutaneous; TopicalAsclemed Usa, Inc.2014-08-01Not applicableUs
Dyural L KitMethylprednisolone acetate (40 mg/1mL) + Isopropyl Alcohol (70 mL/100mL) + Lidocaine hydrochloride (10 mg/1mL) + Povidone-iodine (10 mg/1mL)KitInfiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue; TopicalAsclemed Usa, Inc.2014-08-15Not applicableUs
Dyural LM KitMethylprednisolone acetate (40 mg/1mL) + Bupivacaine hydrochloride monohydrate (2.5 mg/1mL) + Isopropyl Alcohol (70 mL/100mL) + Lidocaine hydrochloride (10 mg/1mL) + Povidone-iodine (10 mg/1mL)KitEpidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue; TopicalAsclemed Usa, Inc.2014-08-21Not applicableUs
HybrisilMethylprednisolone acetate (10 mg/1g)GelTopicalBioZone Laboratories, Inc.2010-05-05Not applicableUs
Medroloan II SUIKMethylprednisolone acetate (40 mg/1mL)Injection, suspensionIntra-articular; Intralesional; Intramuscular; Soft tissueAsclemed Usa, Inc.2016-06-29Not applicableUs
Medroloan SUIKMethylprednisolone acetate (40 mg/1mL)Injection, suspensionIntra-articular; Intralesional; Intramuscular; Soft tissueAsclemed Usa, Inc.2016-06-29Not applicableUs
Multi-Specialty KitMethylprednisolone acetate (40 mg/1mL) + Isopropyl Alcohol (70 mL/100mL) + Lidocaine hydrochloride (10 mg/1mL)KitInfiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue; TopicalAsclemed Usa, Inc.2014-02-06Not applicableUs
Physicians EZ Use M-predMethylprednisolone acetate (40 mg/1mL) + Bupivacaine hydrochloride monohydrate (5 mg/1mL) + Povidone-iodine (10 mg/1g)KitEpidural; Infiltration; Intramuscular; Intrasynovial; Soft tissue; TopicalAsclemed Usa, Inc.2013-05-30Not applicableUs
International/Other Brands
Medrate / Medrol / Medrone / Meprolone / Solomet / Urbason
Categories
UNII
X4W7ZR7023
CAS number
83-43-2
Weight
Average: 374.4706
Monoisotopic: 374.20932407
Chemical Formula
C22H30O5
InChI Key
VHRSUDSXCMQTMA-PJHHCJLFSA-N
InChI
InChI=1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1
IUPAC Name
(1R,3aS,3bS,5S,9aR,9bS,10S,11aS)-1,10-dihydroxy-1-(2-hydroxyacetyl)-5,9a,11a-trimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one
SMILES
[H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])C[C@H](C)C2=CC(=O)C=C[C@]12C

Pharmacology

Indication

Adjunctive therapy for short-term administration in rheumatoid arthritis.

Associated Conditions
Pharmacodynamics

Methylprednisolone and its derivatives, methylprednisolone sodium succinate and methylprednisolone acetate, are synthetic glucocorticoids used as antiinflammatory or immunosuppressive agents.

Mechanism of action

Unbound glucocorticoids cross cell membranes and bind with high affinity to specific cytoplasmic receptors, modifying transcription and protein synthesis. By this mechanism, glucocorticoids can inhibit leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, and suppress humoral immune responses. The antiinflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.

TargetActionsOrganism
AGlucocorticoid receptor
agonist
Human
Absorption

Oral bioavailability 80-99%

Volume of distribution
Not Available
Protein binding

78%

Metabolism

Hepatic

Route of elimination
Not Available
Half life

1-3 hours

Clearance
Not Available
Toxicity

LD50=2000 mg/kg (orally in rat)

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
DrugInteraction
(R)-warfarinThe metabolism of (R)-warfarin can be increased when combined with Methylprednisolone.
(S)-WarfarinThe metabolism of (S)-Warfarin can be increased when combined with Methylprednisolone.
1-TestosteroneThe risk or severity of edema formation can be increased when 1-Testosterone is combined with Methylprednisolone.
1,10-PhenanthrolineThe therapeutic efficacy of 1,10-Phenanthroline can be decreased when used in combination with Methylprednisolone.
16-BromoepiandrosteroneThe risk or severity of edema formation can be increased when 16-Bromoepiandrosterone is combined with Methylprednisolone.
19-norandrostenedioneThe risk or severity of edema formation can be increased when 19-norandrostenedione is combined with Methylprednisolone.
1alpha-Hydroxyvitamin D5The therapeutic efficacy of 1alpha-Hydroxyvitamin D5 can be decreased when used in combination with Methylprednisolone.
2-MethoxyethanolThe risk or severity of adverse effects can be increased when Methylprednisolone is combined with 2-Methoxyethanol.
2,4-thiazolidinedioneThe therapeutic efficacy of 2,4-thiazolidinedione can be decreased when used in combination with Methylprednisolone.
3,5-diiodothyropropionic acidThe metabolism of 3,5-diiodothyropropionic acid can be increased when combined with Methylprednisolone.
Food Interactions
Not Available

References

Synthesis Reference

Klaus Annen, Karl Petzoldt, Henry Laurent, Rudolf Wiechert, Helmut Hofmeister, "Novel 6.alpha.-methylprednisolone derivatives, their preparation, and their use." U.S. Patent US4587236, issued March, 1973.

US4587236
General References
  1. Sloka JS, Stefanelli M: The mechanism of action of methylprednisolone in the treatment of multiple sclerosis. Mult Scler. 2005 Aug;11(4):425-32. [PubMed:16042225]
External Links
Human Metabolome Database
HMDB0015094
KEGG Drug
D00407
PubChem Compound
6741
PubChem Substance
46504885
ChemSpider
6485
BindingDB
50103616
ChEBI
6888
ChEMBL
CHEMBL650
Therapeutic Targets Database
DAP001040
PharmGKB
PA450466
RxList
RxList Drug Page
Drugs.com
Drugs.com Drug Page
Wikipedia
Methylprednisolone
ATC Codes
D07CA02 — Methylprednisolone and antibioticsS01CA08 — Methylprednisolone and antiinfectivesD07AA01 — MethylprednisoloneD10AA02 — MethylprednisoloneH02AB04 — MethylprednisoloneH02BX01 — Methylprednisolone, combinations
AHFS Codes
  • 68:04.00 — Adrenals
  • 84:06.00 — Anti-inflammatory Agents
FDA label
Download (244 KB)
MSDS
Download (72.6 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
0CompletedBasic ScienceInnate Immunity1
0CompletedTreatmentChronic post-traumatic neuropathic pain in ankle and foot1
0CompletedTreatmentFriedreich's Ataxia1
0RecruitingTreatmentRaynaud's Phenomenon / Sclerosis, Progressive Systemic1
0TerminatedTreatmentComplication of Anesthesia During Pregnancy, Unspecified / Fevers / Labour Pain1
1Active Not RecruitingTreatmentProgressive Multiple Sclerosis1
1CompletedBasic ScienceBiological Availability1
1CompletedSupportive CareChronic Myeloproliferative Disorders / Graft Versus Host Disease (GVHD) / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Precancerous/Nonmalignant Condition1
1CompletedTreatmentChronic Myeloproliferative Disorders / Graft Versus Host Disease (GVHD) / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Precancerous/Nonmalignant Condition / Small Intestine Cancer1
1CompletedTreatmentChronic Myeloproliferative Disorders / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases1
1CompletedTreatmentDisseminated Sclerosis2
1CompletedTreatmentDrug Drug Interaction (DDI)1
1CompletedTreatmentKnee Osteoarthritis (Knee OA)1
1CompletedTreatmentNeuroblastomas / Sarcomas / Unspecified Childhood Solid Tumor, Protocol Specific1
1RecruitingBasic ScienceNormal Physiology1
1RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Leukemia Acute Myeloid Leukemia (AML) / Untreated Adult Acute Myeloid Leukemia1
1RecruitingTreatmentCongenital Hypoplastic Anemia1
1RecruitingTreatmentContiguous Stage II Adult Lymphoblastic Lymphoma / Noncontiguous Stage II Adult Lymphoblastic Lymphoma / Stage I Adult Lymphoblastic Lymphoma / Stage III Adult Lymphoblastic Lymphoma / Stage IV Adult Lymphoblastic Lymphoma / Untreated Adult Acute Lymphoblastic Leukemia1
1RecruitingTreatmentGraft Versus Host Disease (GVHD) / Sickle Cell Disorders1
1RecruitingTreatmentMultiple Myeloma (MM)1
1RecruitingTreatmentStatus Asthmaticus1
1TerminatedNot AvailableDisseminated Sclerosis / Healthy Volunteers1
1TerminatedTreatmentMyasthenia Gravis1
1TerminatedTreatmentMyopathies1
1TerminatedTreatmentRheumatoid Arthritis1
1Unknown StatusSupportive CareGraft Versus Host Disease (GVHD) / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes1
1Unknown StatusTreatmentLeukemias / Myelodysplastic Syndromes1
1Unknown StatusTreatmentMalignant Lymphomas1
1Unknown StatusTreatmentNeuromyelitis Optica1
1Unknown StatusTreatmentOcular GVHD1
1Unknown StatusTreatmentUnspecified Childhood Solid Tumor, Protocol Specific1
1WithdrawnBasic ScienceTherapeutic Equivalency3
1, 2Active Not RecruitingTreatmentClassical Hodgkin Lymphoma1
1, 2Active Not RecruitingTreatmentDrug-Induced Liver Injury, Chronic1
1, 2Active Not RecruitingTreatmentNeuromyelitis Optica1
1, 2CompletedPreventionOvarian Hyperstimulation Syndrome1
1, 2CompletedTreatmentAcute Lymphocytic Leukemia (ALL) / Leukemias1
1, 2CompletedTreatmentCongenital Hypoplastic Anemia1
1, 2CompletedTreatmentInhospital Cardiac Arrest1
1, 2CompletedTreatmentKidney Diseases / Transplantation, Kidney1
1, 2CompletedTreatmentLeukemias1
1, 2CompletedTreatmentSpinal Cord Injuries (SCI)2
1, 2CompletedTreatmentSystemic Lupus Erythematosus (SLE)1
1, 2CompletedTreatmentTraumatic Optic Neuropathy1
1, 2Not Yet RecruitingTreatmentAcute Graft-Versus-Host Disease1
1, 2RecruitingPreventionCognitive Retention Disorder / Postoperative Complications1
1, 2RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Acute Myelogenous Leukaemia (AML) / Chronic Myeloid Leukemia (CML) / Juvenile Myelomonocytic Leukemia (JMML) / Lymphoma (Hodgkin's and Non-Hodgkin's) / Myelodysplastic Syndromes (MDS)1
1, 2RecruitingTreatmentCongenital Hypoplastic Anemia1
1, 2RecruitingTreatmentDisseminated Sclerosis1
1, 2RecruitingTreatmentLeukemia Acute Myeloid Leukemia (AML) / Leukemias / Myelodysplastic Syndrome1
1, 2TerminatedTreatmentLeukemias1
1, 2TerminatedTreatmentLeukemias / Myeloproliferative Disorders / Plasma Cell Myeloma1
1, 2Unknown StatusNot AvailableAtherosclerosis1
1, 2WithdrawnPreventionNoise Induced Hearing Loss1
2Active Not RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / Adult Acute Lymphoblastic Leukemia in Remission / Adult B Acute Lymphoblastic Leukemia / Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 / Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1 / Adult L1 Acute Lymphoblastic Leukemia / Adult L2 Acute Lymphoblastic Leukemia / Adult T Acute Lymphoblastic Leukemia / Recurrent Adult Acute Lymphoblastic Leukemia / Untreated Adult Acute Lymphoblastic Leukemia1
2Active Not RecruitingTreatmentAnaplastic Large Cell Lymphoma, ALK-Negative / Angioimmunoblastic T-Cell Lymphoma / Enteropathy-Associated T-Cell Lymphoma / Hepatosplenic Gamma/ Delta T-cell Lymphoma / Peripheral T-cell Lymphoma NOS1
2Active Not RecruitingTreatmentChronic Lymphocytic Leukaemia (CLL) / Small Lymphocytic Lymphoma (SLL)2
2Active Not RecruitingTreatmentLeukemias2
2Active Not RecruitingTreatmentLymphoproliferative Disorders1
2Active Not RecruitingTreatmentMalignant Lymphomas1
2Active Not RecruitingTreatmentNephritis, Lupus2
2Active Not RecruitingTreatmentRelapsing Remitting Multiple Sclerosis (RRMS)1
2Active Not RecruitingTreatmentTransplantation, Kidney1
2CompletedDiagnosticMalignant Lymphomas1
2CompletedPreventionHyperalgesia / Knee Joint Osteoarthrosis / Severe Movement Related Pain1
2CompletedSupportive CareCancer of the Ovary / Cancer, Breast / Chronic Myeloproliferative Disorders / Gestational Trophoblastic Disease / Graft Versus Host Disease (GVHD) / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases / Neuroblastomas / Testicular germ cell tumour2
2CompletedSupportive CareMalignancies1
2CompletedSupportive CareMalignant Lymphomas / Neutropenias1
2CompletedTreatmentAbdominal wall neoplasm / Carcinomatosis / Intestinal Obstruction1
2CompletedTreatmentAccelerated Phase Chronic Myelogenous Leukemia / Adult Acute Lymphoblastic Leukemia in Remission / Adult Acute Megakaryoblastic Leukemia (M7) / Adult Acute Monoblastic Leukemia (M5a) / Adult Acute Monocytic Leukemia (M5b) / Adult Acute Myeloblastic Leukemia With Maturation (M2) / Adult Acute Myeloblastic Leukemia Without Maturation (M1) / Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With Del(5q) / Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) / Adult Acute Myeloid Leukemia With T(15;17)(q22;q12) / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Acute Myeloid Leukemia With T(8;21)(q22;q22) / Adult Acute Myelomonocytic Leukemia (M4) / Adult Acute Promyelocytic Leukemia (M3) / Adult Erythroleukemia (M6a) / Adult Nasal Type Extranodal NK/T-Cell Lymphoma / Adult Pure Erythroid Leukemia (M6b) / Anaplastic Large Cell Lymphoma / Angioimmunoblastic T-Cell Lymphoma / Burkitt's Lymphoma / Childhood Acute Erythroleukemia (M6) / Childhood Acute Lymphoblastic Leukemia in Remission / Childhood Acute Megakaryocytic Leukemia (M7) / Childhood Acute Monoblastic Leukemia (M5a) / Childhood Acute Monocytic Leukemia (M5b) / Childhood Acute Myeloblastic Leukemia With Maturation (M2) / Childhood Acute Myeloblastic Leukemia Without Maturation (M1) / Childhood Acute Myeloid Leukemia in Remission / Childhood Acute Myelomonocytic Leukemia (M4) / Childhood Acute Promyelocytic Leukemia (M3) / Childhood Chronic Myelogenous Leukemia / Childhood Myelodysplastic Syndromes / Chronic Phase Chronic Myelogenous Leukemia / Cutaneous B-Cell Non-Hodgkin Lymphoma / De Novo Myelodysplastic Syndromes / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Hepatosplenic T-Cell Lymphoma / Intraocular Lymphoma / Nodal marginal zone B-cell lymphomas / Peripheral T-Cell Lymphoma (PTCL) / Post Transplant Lymphoproliferative Disorder / Previously Treated Myelodysplastic Syndromes / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Myeloid Leukemia / Recurrent Adult Burkitt Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Grade III Lymphomatoid Granulomatosis / Recurrent Adult Hodgkin's Lymphoma / Recurrent Adult Immunoblastic Large Cell Lymphoma / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Adult Non-Hodgkin Lymphoma / Recurrent Adult T-Cell Leukemia/Lymphoma / Recurrent Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood Acute Myeloid Leukemia / Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Mycosis Fungoides/Sezary Syndrome / Recurrent Small Lymphocytic Lymphoma / Refractory Multiple Myeloma / Relapsing Chronic Myelogenous Leukemia / Secondary Myelodysplastic Syndromes / Small Intestine Lymphoma / Splenic Marginal Zone Lymphoma / Testicular Lymphoma / Waldenström's Macroglobulinemia (WM)1
2CompletedTreatmentAccelerated Phase Chronic Myelogenous Leukemia / Blastic Phase Chronic Myelogenous Leukemia / Childhood Acute Lymphoblastic Leukemia in Remission / Childhood Acute Myeloid Leukemia in Remission / Childhood Chronic Myelogenous Leukemia / Childhood Myelodysplastic Syndromes / Chronic Phase Chronic Myelogenous Leukemia / De Novo Myelodysplastic Syndromes / Disseminated Neuroblastoma / Juvenile Myelomonocytic Leukemia / Previously Treated Childhood Rhabdomyosarcoma / Previously Treated Myelodysplastic Syndromes / Pulmonary Complications / Recurrent Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood Acute Myeloid Leukemia / Recurrent Childhood Large Cell Lymphoma / Recurrent Childhood Lymphoblastic Lymphoma / Recurrent Childhood Rhabdomyosarcoma / Recurrent Childhood Small Noncleaved Cell Lymphoma / Recurrent Neuroblastoma / Recurrent Wilms Tumor and Other Childhood Kidney Tumors / Recurrent/Refractory Childhood Hodgkin Lymphoma / Relapsing Chronic Myelogenous Leukemia / Secondary Acute Myeloid Leukemia (Secondary AML, sAML) / Secondary Myelodysplastic Syndromes1
2CompletedTreatmentAcute Lung Injury (ALI) / Acute Respiratory Distress Syndrome (ARDS) / Postoperative Complications1
2CompletedTreatmentAcute Lymphoblastic Leukaemias (ALL) / Leukemias1
2CompletedTreatmentAcute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome / Adult Acute Lymphoblastic Leukemia in Remission / Adult Acute Megakaryoblastic Leukemia (M7) / Adult Acute Minimally Differentiated Myeloid Leukemia (M0) / Adult Acute Monoblastic Leukemia (M5a) / Adult Acute Monocytic Leukemia (M5b) / Adult Acute Myeloid Leukemia in Remission / Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities / Adult Acute Myeloid Leukemia With T(16;16)(p13;q22) / Adult Erythroleukemia (M6a) / Adult Nasal Type Extranodal NK/T-Cell Lymphoma / Adult Pure Erythroid Leukemia (M6b) / B-cell Adult Acute Lymphoblastic Leukemia / B-cell Childhood Acute Lymphoblastic Leukemia / Blastic Phase Chronic Myelogenous Leukemia / Burkitt's Lymphoma / Childhood Acute Erythroleukemia (M6) / Childhood Acute Lymphoblastic Leukemia in Remission / Childhood Acute Megakaryocytic Leukemia (M7) / Childhood Acute Minimally Differentiated Myeloid Leukemia (M0) / Childhood Acute Monoblastic Leukemia (M5a) / Childhood Acute Monocytic Leukemia (M5b) / Childhood Acute Myeloid Leukemia in Remission / Childhood Chronic Myelogenous Leukemia / Childhood Diffuse Large Cell Lymphoma / Childhood Immunoblastic Large Cell Lymphoma / Childhood Myelodysplastic Syndromes / Childhood Nasal Type Extranodal NK/T-cell Lymphoma / Chronic Lymphocytic Leukemia (CLL) - Refractory / Chronic Myelomonocytic Leukemia / Chronic Phase Chronic Myelogenous Leukemia / Cutaneous B-Cell Non-Hodgkin Lymphoma / De Novo Myelodysplastic Syndromes / Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue / Juvenile Myelomonocytic Leukemia / Leukemia, Prolymphocytic / Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable / Nodal marginal zone B-cell lymphomas / Previously Treated Myelodysplastic Syndromes / Recurrent Adult Acute Lymphoblastic Leukemia / Recurrent Adult Acute Myeloid Leukemia / Recurrent Adult Burkitt Lymphoma / Recurrent Adult Diffuse Large Cell Lymphoma / Recurrent Adult Diffuse Mixed Cell Lymphoma / Recurrent Adult Diffuse Small Cleaved Cell Lymphoma / Recurrent Adult Grade III Lymphomatoid Granulomatosis / Recurrent Adult Immunoblastic Large Cell Lymphoma / Recurrent Adult Lymphoblastic Lymphoma / Recurrent Childhood Acute Lymphoblastic Leukemia / Recurrent Childhood Acute Myeloid Leukemia / Recurrent Childhood Anaplastic Large Cell Lymphoma / Recurrent Childhood Grade III Lymphomatoid Granulomatosis / Recurrent Childhood Large Cell Lymphoma / Recurrent Childhood Lymphoblastic Lymphoma / Recurrent Childhood Small Noncleaved Cell Lymphoma / Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma / Recurrent Grade 1 Follicular Lymphoma / Recurrent Grade 2 Follicular Lymphoma / Recurrent Grade 3 Follicular Lymphoma / Recurrent Mantle Cell Lymphoma / Recurrent Marginal Zone Lymphoma / Recurrent Mycosis Fungoides/Sezary Syndrome / Recurrent Small Lymphocytic Lymphoma / Relapsing Chronic Myelogenous Leukemia / Secondary Acute Myeloid Leukemia (Secondary AML, sAML) / Secondary Myelodysplastic Syndromes / Secondary Myelofibrosis / Splenic Marginal Zone Lymphoma / Stage I Chronic Lymphocytic Leukemia / Stage II Chronic Lymphocytic Leukemia / Stage III Chronic Lymphocytic Leukemia / Stage IV Chronic Lymphocytic Leukemia / T-cell Adult Acute Lymphoblastic Leukemia / T-cell Childhood Acute Lymphoblastic Leukemia / T-Cell Large Granular Lymphocyte Leukemia / Waldenström's Macroglobulinemia (WM)1
2CompletedTreatmentAdverse Effect of Radiation Therapy / Brain Necrosis / Nasopharyngeal Carcinoma1
2CompletedTreatmentAmyotrophic Lateral Sclerosis (ALS)1
2CompletedTreatmentAplastic Anaemia (AA)1
2CompletedTreatmentAplastic Anaemia (AA) / Myelodysplastic Syndrome1
2CompletedTreatmentBlood Cancers / Chronic Lymphocytic Leukaemia (CLL) / Graft Versus Host Disease (GVHD) / Hodgkins Disease (HD) / Leukemias / Malignancies / NHL / Smith-Magenis Syndrome1
2CompletedTreatmentBursitis1
2CompletedTreatmentCancer of the Ovary / Cancer, Breast / Fallopian Tube Cancer / Primary Peritoneal Cancer1
2CompletedTreatmentChildhood Burkitt Lymphoma / Childhood Diffuse Large Cell Lymphoma / Childhood Immunoblastic Large Cell Lymphoma / Stage I Childhood Large Cell Lymphoma / Stage I Childhood Small Noncleaved Cell Lymphoma / Stage II Childhood Large Cell Lymphoma / Stage II Childhood Small Noncleaved Cell Lymphoma / Stage III Childhood Large Cell Lymphoma / Stage III Childhood Small Noncleaved Cell Lymphoma / Stage IV Childhood Large Cell Lymphoma / Stage IV Childhood Small Noncleaved Cell Lymphoma / Untreated Childhood Acute Lymphoblastic Leukemia1
2CompletedTreatmentChronic B-Lymphocytic Leukemia1
2CompletedTreatmentChronic Lymphocytic Leukaemia (CLL) / Non-Hodgkin's Lymphoma (NHL)1
2CompletedTreatmentChronic Myeloproliferative Disorders / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases1
2CompletedTreatmentChronic Renal Failure (CRF) / Transplantation, Kidney1
2CompletedTreatmentCongenital Amegakaryocytic Thrombocytopenia / Congenital Hypoplastic Anemia / Leukemias / Myelodysplastic Syndromes / Severe Congenital Neutropenia1
2CompletedTreatmentConnective Tissue Diseases / Dermatomyositis / Vasculitis / Vasculitis, Hypersensitivity1
2CompletedTreatmentGiant Cell Myocarditis / Myocarditis1
2CompletedTreatmentGraft Versus Host Disease (GVHD)1
2CompletedTreatmentGraft Versus Host Disease (GVHD) / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes1
2CompletedTreatmentGraft Versus Host Disease (GVHD) / Leukemias / Malignant Lymphomas / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases1
2CompletedTreatmentGraft Versus Host Disease (GVHD) / Leukemias / Malignant Lymphomas / Myelodysplastic Syndromes / Neuroblastomas1
2CompletedTreatmentGraft Versus Host Disease (GVHD) / Leukemias / Myelodysplastic Syndromes1
2CompletedTreatmentGraft Versus Host Disease (GVHD) / Leukemias / Myelodysplastic Syndromes / Thymic Carcinoma1
2CompletedTreatmentGranulomatosis With Polyangiitis / Microscopic Polyangiitis / Renal Limited Vasculitis1
2CompletedTreatmentHantavirus Infections1
2CompletedTreatmentHormone Resistant Prostate Cancer / Metastatic Hormone Refractory Prostate Cancer1
2CompletedTreatmentLeukemia, Mast-Cell / Mantle Cell Lymphoma (MCL)1
2CompletedTreatmentLeukemias3
2CompletedTreatmentLeukemias / Malignant Lymphomas1
2CompletedTreatmentLeukemias / Malignant Lymphomas / Myelodysplastic Syndromes / Myelodysplastic-Myeloproliferative Diseases1
2CompletedTreatmentLeukemias / Malignant Lymphomas / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases1
2CompletedTreatmentLeukemias / Malignant Lymphomas / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Neoplasms1
2CompletedTreatmentLeukemias / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes1
2CompletedTreatmentLeukemias / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases1
2CompletedTreatmentLupus Erythematosus, Systemic1
2CompletedTreatmentMalignant Lymphomas2
2CompletedTreatmentMultiple Myeloma (MM)1
2CompletedTreatmentNephritis, Lupus1
2CompletedTreatmentProgressive Multiple Sclerosis1
2CompletedTreatmentRejection, Transplant1
2CompletedTreatmentRelapsing Remitting Multiple Sclerosis (RRMS)1
2CompletedTreatmentRheumatoid Arthritis2
2CompletedTreatmentSuspected Appendicitis1
2Enrolling by InvitationTreatmentDisseminated Sclerosis1
2Enrolling by InvitationTreatmentGraft Versus Host Disease (GVHD)1
2Not Yet RecruitingPreventionAcute GvHD1
2Not Yet RecruitingTreatmentAcute-graft-versus-host Disease1
2Not Yet RecruitingTreatmentAntibody-mediated Rejection / Lung Transplant Rejection1
2Not Yet RecruitingTreatmentCaustic Esophageal Injury / Esophageal Strictures / Pharyngeal stenosis1
2Not Yet RecruitingTreatmentHigh Cholesterol / Thyroid Associated Ophthalmopathy1
2Not Yet RecruitingTreatmentImmune Thrombocytopenia1
2Not Yet RecruitingTreatmentSystemic Lupus Erythematosus Arthritis1
2RecruitingTreatmentAplastic Anaemia (AA) / Hypoplastic Myelodysplastic Syndrome1
2RecruitingTreatmentCerebral Radiation Necrosis1
2RecruitingTreatmentCongenital Hypoplastic Anemia1
2RecruitingTreatmentCrohn's Disease (CD)1
2RecruitingTreatmentDisseminated Sclerosis1
2RecruitingTreatmentGraft Versus Host Disease (GVHD)1
2RecruitingTreatmentGraft Versus Host Disease, Acute1
2RecruitingTreatmentHenoch-Schoenlein Purpura Nephritis1
2RecruitingTreatmentIgA Glomerulonephritis / Necrosis / Peripapillary Crescent / Steroid Nephropathy1
2RecruitingTreatmentLeukemias2
2RecruitingTreatmentLung Cancer Non-Small Cell Cancer (NSCLC)1
2RecruitingTreatmentMultiple Myeloma (MM)1
2RecruitingTreatmentMultiple Sclerosis, Chronic Progressive / Nervous System Diseases1
2RecruitingTreatmentNon-Hodgkin's Lymphoma (NHL)1
2RecruitingTreatmentSystemic Lupus Erythematosus Arthritis1
2RecruitingTreatmentTransplant, Kidney1
2TerminatedNot AvailableAcute Exacerbation of Remitting Relapsing Multiple Sclerosis / Clinically Isolated Syndrome (CIS)1
2TerminatedTreatmentBlood and Marrow Transplant (BMT) / Diffuse Large B-Cell / Lymphoma, B-Cell / Lymphoma, Large B-Cell, Diffuse (DLBCL) / Lymphomas: Non-Hodgkin / Malignant Lymphoma, Non-Hodgkin / Non-Hodgkin's Lymphoma (NHL)1
2TerminatedTreatmentChronic Myeloproliferative Disorders / Graft Versus Host Disease (GVHD) / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes1
2TerminatedTreatmentChronic Myeloproliferative Disorders / Graft Versus Host Disease (GVHD) / Leukemias / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes1
2TerminatedTreatmentChronic Myeloproliferative Disorders / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Neoplasms / Unusual Cancers of Childhood1
2TerminatedTreatmentChronic Myeloproliferative Disorders / Leukemias / Myelodysplastic/Myeloproliferative Diseases1
2TerminatedTreatmentEnd-Stage Renal Disease (ESRD)1
2TerminatedTreatmentGraves Ophthalmopathy1
2TerminatedTreatmentHaematological Malignancies1
2TerminatedTreatmentInsufficiency; Hepatic, Postoperative / Ischemic Reperfusion Injury / Neoplasms, Hepatic1
2TerminatedTreatmentLeukemias1
2TerminatedTreatmentLeukemias / Myelodysplastic Syndromes1
2TerminatedTreatmentMalignant Lymphomas1
2TerminatedTreatmentNon-Hodgkin's Lymphoma (NHL)2
2TerminatedTreatmentPelvic Girdle Pain1
2TerminatedTreatmentPolyp of Nasal Sinus1
2TerminatedTreatmentPrimary Renal Allograft Candidate / Transplantation, Kidney1
2TerminatedTreatmentPrimary Simultaneous Kidney and Pancreas Allograft Candidates / Simultaneous Kidney and Pancreas Transplantation1
2TerminatedTreatmentRheumatoid Arthritis3
2TerminatedTreatmentSpondylarthropathy1
2TerminatedTreatmentTransplant, Kidney1
2TerminatedTreatmentTransplantation, Kidney1
2TerminatedTreatmentTransplantation, Kidney / Transplantation, Renal1
2Unknown StatusTreatmentAcute Lung Injury (ALI) / Acute Respiratory Distress Syndrome (ARDS)1
2Unknown StatusTreatmentAnkylosing Spondylitis (AS)1
2Unknown StatusTreatmentChildhood Langerhans Cell Histiocytosis / Congenital Hypoplastic Anemia / Leukemias / Malignant Lymphomas / Myelodysplastic Syndromes / Neuroblastomas / Sarcomas / Unspecified Childhood Solid Tumor, Protocol Specific1
2Unknown StatusTreatmentEarly and Severe Systemic Sclerosis1
2Unknown StatusTreatmentElective Cardiac Surgery1
2Unknown StatusTreatmentLeukemias1
2Unknown StatusTreatmentLeukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes1
2Unknown StatusTreatmentLymphoma, Large B-Cell, Diffuse (DLBCL)1
2Unknown StatusTreatmentMalignant Lymphomas1
2Unknown StatusTreatmentPrimary Central Nervous System Lymphoma (PCNSL)1
2WithdrawnTreatmentAdult Non-Hodgkin's Lymphoma / Anaplastic Large Cell Lymphoma / Lymphoma, AIDS Related1
2WithdrawnTreatmentChronic Graft Versus Host Disease1
2WithdrawnTreatmentDisseminated Sclerosis1
2WithdrawnTreatmentGraft Versus Host Disease, Acute / Intestinal Graft Versus Host Disease1
2WithdrawnTreatmentLung Cancers / Melanoma / Renal Cell Adenocarcinoma1
2WithdrawnTreatmentPlasma Cell Myeloma1
2WithdrawnTreatmentSystemic Lupus Erythematosus (SLE)1
2, 3Active Not RecruitingTreatmentChildhood B Acute Lymphoblastic Leukemia / Childhood Burkitt Leukemia / Childhood Diffuse Large Cell Lymphoma / Mediastinal (Thymic) Large B-Cell Lymphoma / Stage III Childhood Large Cell Lymphoma / Stage IV Childhood Large Cell Lymphoma1
2, 3CompletedNot AvailableDegenerative Joint Disease2
2, 3CompletedTreatmentAcute Alcoholic Hepatitis1
2, 3CompletedTreatmentAdult B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1 / Childhood B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1 / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
2, 3CompletedTreatmentAplastic Anaemia (AA) / Dyskeratosis Congenita1
2, 3CompletedTreatmentCarpal Tunnel Syndrome (CTS)1
2, 3CompletedTreatmentFamilial Lipoprotein Lipase Deficiency1
2, 3CompletedTreatmentGraft Versus Host Disease (GVHD) / Leukemias / Myelodysplastic Syndromes1
2, 3CompletedTreatmentGranulomatosis With Polyangiitis / Microscopic Polyangiitis / Vasculitis1
2, 3CompletedTreatmentLeukemias / Malignant Lymphomas / Myelodysplastic Syndromes1
2, 3CompletedTreatmentLumbosacral Radiculopathy1
2, 3CompletedTreatmentMenière's Disease1
2, 3CompletedTreatmentOphthalmopathy, Thyroid-Associated1
2, 3CompletedTreatmentOptic Neuritis1
2, 3CompletedTreatmentSinusitis1
2, 3Not Yet RecruitingTreatmentThyroid Eye Disease1
2, 3RecruitingPreventionComplications1
2, 3RecruitingTreatmentAcute Gouty Arthritis / Chronic Kidney Disease (CKD)1
2, 3RecruitingTreatmentDiabetes Complications / Neuropathic arthropathy1
2, 3RecruitingTreatmentHeart Arrest1
2, 3RecruitingTreatmentLeukemias1
2, 3RecruitingTreatmentScleroderma / Sclerosis, Progressive Systemic1
2, 3TerminatedTreatmentDisseminated Sclerosis1
2, 3TerminatedTreatmentLupus Erythematosus, Systemic1
2, 3Unknown StatusTreatmentAcute Lung Injury (ALI) / ARDS, Human1
3Active Not RecruitingPreventionDysphasia1
3Active Not RecruitingPreventionSwallowing Disorders1
3Active Not RecruitingTreatmentCardiopulmonary Bypass1
3Active Not RecruitingTreatmentDrug/Agent Toxicity by Tissue/Organ / Leukemias1
3CompletedNot AvailableDegenerative Joint Disease4
3CompletedPreventionFacial Paralysis1
3CompletedPreventionKidney Diseases1
3CompletedPreventionPost-Extubation Laryngeal Edema1
3CompletedPreventionTransplantation, Kidney1
3CompletedSupportive CareGraft Versus Host Disease (GVHD)1
3CompletedSupportive CareGraft Versus Host Disease (GVHD) / Recurrent Adult Acute Lymphoblastic Leukemia1
3CompletedSupportive CareMalignancies / Pain NOS1
3CompletedTreatmentAbdominal Pain (AP)1
3CompletedTreatmentAcute Lymphoblastic Leukaemias (ALL) / Acute Undifferentiated Leukemia (AUL) / Childhood T Acute Lymphoblastic Leukemia / T-cell Childhood Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
3CompletedTreatmentCardiac Arrest1
3CompletedTreatmentChronic Kidney Disease (CKD) / IgA Nephropathy1
3CompletedTreatmentChronic Lung Disease of Prematurity1
3CompletedTreatmentChronic Lung Diseases / Respiratory Distress Syndrome, Adult1
3CompletedTreatmentCommunity Acquired Respiratory Disease Syndrome1
3CompletedTreatmentDexamethasone-induced Hiccup in Chemotherapy1
3CompletedTreatmentGraft Versus Host Disease (GVHD)1
3CompletedTreatmentHeart Diseases / Heart Transplantation1
3CompletedTreatmentHemangiomas1
3CompletedTreatmentIdiopathic Pneumonia Syndrome / Pneumonia1
3CompletedTreatmentImmune Thrombocytopenic Purpura ( ITP )1
3CompletedTreatmentLeukemias1
3CompletedTreatmentMalignant Lymphomas3
3CompletedTreatmentMultiple Sclerosis, Chronic Progressive1
3CompletedTreatmentNephritis, Lupus1
3CompletedTreatmentRadicular Low Back Pain1
3CompletedTreatmentRheumatoid Arthritis4
3CompletedTreatmentSpinal Cord Injuries (SCI)1
3CompletedTreatmentSudden Deafness1
3CompletedTreatmentTransplant; Failure, Kidney1
3CompletedTreatmentTransplantation, Kidney3
3Not Yet RecruitingTreatmentArterial Ischemic Stroke1
3Not Yet RecruitingTreatmentChronic Graft Versus Host Disease1
3Not Yet RecruitingTreatmentPersistent ARDS1
3Not Yet RecruitingTreatmentProstate Cancer1
3RecruitingPreventionHerniated Nucleus Pulposus / Intervertebral Disc Degeneration / Myelopathy / Myeloradiculopathy / Radicular syndrome / Spondylosis / Stenosis1
3RecruitingTreatmentAcute Graft-Versus-Host Disease / Graft-versus-host Disease (GVHD)1
3RecruitingTreatmentAcute Lymphoblastic Leukaemias (ALL) / B Acute Lymphoblastic Leukemia / B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1 / BCR-ABL1 Fusion Protein Expression / Minimal Residual Disease / Philadelphia Chromosome Positive / T Acute Lymphoblastic Leukemia / Untreated Adult Acute Lymphoblastic Leukemia / Untreated Childhood Acute Lymphoblastic Leukemia1
3RecruitingTreatmentAging1
3RecruitingTreatmentChronic Subdural Hematomas1
3RecruitingTreatmentCongenital Heart Disease in Children / Inflammatory Responses1
3RecruitingTreatmentDisseminated Sclerosis1
3RecruitingTreatmentDry Eye Syndrome (DES) / Ophthalmopathy, Thyroid-Associated1
3RecruitingTreatmentGlomerulonephritis membranous1
3RecruitingTreatmentGlomerulonephritis, Membranous1
3RecruitingTreatmentGlucocorticoid therapy / Immunocompromised Patients / Immunosuppressive Agents / Neoplasms / Neoplasms, Hematologic / Pneumocystis1
3RecruitingTreatmentLymphohistiocytosis, Hemophagocytic2
3RecruitingTreatmentRelapsing Remitting Multiple Sclerosis (RRMS)1
3RecruitingTreatmentThrombocytopenias1
3SuspendedTreatmentSpinal Cord Injuries (SCI)1
3TerminatedTreatmentDisseminated Sclerosis1
3TerminatedTreatmentEvidence of Liver Transplantation / Transplantations1
3TerminatedTreatmentGlomerulonephritis1
3TerminatedTreatmentHuman Immunodeficiency Virus (HIV) Infections / Pneumonia, Pneumocystis Carinii1
3TerminatedTreatmentMalignant Lymphomas1
3TerminatedTreatmentNeuromyelitis Optica / Transverse Myelitis1
3TerminatedTreatmentProstate Cancer1
3TerminatedTreatmentSystemic Lupus Erythematosus (SLE)1
3Unknown StatusTreatmentChronic Lymphocytic Leukaemia (CLL)1
3Unknown StatusTreatmentDisseminated Sclerosis / Optic Neuritis1
3Unknown StatusTreatmentLeukemias / Malignant Lymphomas1
3Unknown StatusTreatmentMalignant Lymphomas1
3Unknown StatusTreatmentMultiple Myeloma and Plasma Cell Neoplasm1
3Unknown StatusTreatmentNAION( Non-arteritic Anterior Ischemic Optic Neuropathy)1
3Unknown StatusTreatmentOsteoarthritis (OA)1
3Unknown StatusTreatmentRelapsing Remitting Multiple Sclerosis (RRMS)1
3Unknown StatusTreatmentUrinary Tract Infections (UTIs)1
3Unknown StatusTreatmentVestibular Neuritis1
3WithdrawnTreatmentGraft Versus Host Disease (GVHD) / Leukemias / Malignant Lymphomas1
3WithdrawnTreatmentHuman Immunodeficiency Virus (HIV) Infections / Pneumonia, Pneumocystis Carinii1
4Active Not RecruitingPreventionInfections, Cytomegalovirus / Transplantation Infection1
4Active Not RecruitingPreventionPostoperative Complications1
4Active Not RecruitingTreatmentPlantar fascial fibromatosis1
4CompletedNot AvailableHealthy Volunteers1
4CompletedNot AvailableRelapsing Remitting Multiple Sclerosis (RRMS)1
4CompletedPreventionAdrenocortical Deficiency / Hemodynamics Instability1
4CompletedPreventionDelirium - Postoperative / Stress, Physiological1
4CompletedPreventionEsophageal Diseases1
4CompletedPreventionHysterectomy / Methylprednisolone / Postoperative pain1
4CompletedPreventionMigraines1
4CompletedPreventionTransplantation, Kidney2
4CompletedPreventionTransplantation, Liver1
4CompletedSupportive CareInflammatory Responses / LOS / Post-Operative Nausea and Vomiting (PONV) / Postoperative pain / Sleeping Quality / Tiredness1
4CompletedSupportive CareInflammatory Responses / Post-Operative Nausea and Vomiting (PONV) / Postoperative pain / Sleeping Quality / Tiredness1
4CompletedTreatmentAcute Respiratory Distress Syndrome (ARDS)1
4CompletedTreatmentAdrenal Insufficiency / Tendinopathy1
4CompletedTreatmentAlopecia Totalis (AT) / Alopecia Universalis (AU) / Ophiasic Alopecia1
4CompletedTreatmentAsthma Acute / Asthma Bronchial / Reactive Airway Exacerbation1
4CompletedTreatmentAsthma Bronchial1
4CompletedTreatmentAtopic Dermatitis (AD)1
4CompletedTreatmentCalcifying Tendinitis of Shoulder1
4CompletedTreatmentCarpal Tunnel Syndrome (CTS)1
4CompletedTreatmentChildren / Chronic Rhinosinusitis1
4CompletedTreatmentCommunity Acquired Pneumonia (CAP)1
4CompletedTreatmentCrohn's Disease (CD)1
4CompletedTreatmentDisseminated Sclerosis1
4CompletedTreatmentHLA Sensitization1
4CompletedTreatmentHeart Transplantation1
4CompletedTreatmentImplant or Graft; Rejection1
4CompletedTreatmentKnee Osteoarthritis (Knee OA)1
4CompletedTreatmentLiver Cirrhosis / Liver Transplant Disorder1
4CompletedTreatmentMigrainous Headache1
4CompletedTreatmentNeoplasms, Lung1
4CompletedTreatmentNephritis, Lupus1
4CompletedTreatmentOsteoarthritis (OA)2
4CompletedTreatmentPlantar fascial fibromatosis1
4CompletedTreatmentRejection, Transplant / Renal Failure / Transplantation, Kidney1
4CompletedTreatmentRelapsing Remitting Multiple Sclerosis (RRMS)3
4CompletedTreatmentRheumatoid Arthritis5
4CompletedTreatmentSarcopenia1
4CompletedTreatmentSciatica1
4CompletedTreatmentSepsis1
4CompletedTreatmentArthralgia/joint pain / TMJ1
4CompletedTreatmentTransplantation, Kidney1
4CompletedTreatmentTransplantation, Liver1
4CompletedTreatmentViral Bronchiolitis1
4CompletedTreatmentAcute fulminant liver failure1
4Enrolling by InvitationTreatmentOsteoarthritis (OA)1
4Not Yet RecruitingPreventionGraves Ophthalmopathy1
4Not Yet RecruitingPreventionPost-Craniotomy Headache / Postoperative pain1
4Not Yet RecruitingTreatmentAcromioclavicular Joint Resection / Acromioplasty / Arthroscopic Shoulder Surgery / Intra-articular Debridement / Subacromial Decompression1
4Not Yet RecruitingTreatmentThyroid Associated Ophthalmopathy1
4RecruitingOtherUlcerative Colitis (UC)1
4RecruitingPreventionEnd-Stage Renal Disease (ESRD)1
4RecruitingTreatmentAdhesive Capsulitis / Adhesive Capsulitis of Shoulder / Shoulder Frozen1
4RecruitingTreatmentC.Surgical Procedure / Cardiac1
4RecruitingTreatmentChronic Obstructive Pulmonary Disease (COPD)1
4RecruitingTreatmentCommunity Acquired Pneumonia (CAP)1
4RecruitingTreatmentCrohn's Disease (CD) / Inflammatory Bowel Diseases (IBD)1
4RecruitingTreatmentDisseminated Sclerosis2
4RecruitingTreatmentDrug Interaction Potentiation / Transplantation, Kidney1
4RecruitingTreatmentImmunosuppression1
4RecruitingTreatmentKnee Osteoarthritis (Knee OA)1
4RecruitingTreatmentOrthopedic Surgeries1
4RecruitingTreatmentPost-operative Edema / Steroid Use1
4RecruitingTreatmentThyroid Associated Ophthalmopathy1
4RecruitingTreatmentUlcerative Colitis (UC)1
4RecruitingTreatmentAcute nonspecific tenosynovitis1
4SuspendedTreatmentWegener's Granulomatosis or Microscopic Polyangiitis / Wegener's Granulomatosis, Microscopic Polyangiitis1
4TerminatedTreatmentChronic Obstructive Pulmonary Disease (COPD)1
4TerminatedTreatmentImmune Reconstitution Inflammatory Syndrome / Progressive Multifocal Leukoencephalopathy1
4TerminatedTreatmentTransplants and Implants1
4Unknown StatusTreatmentBehcet's Syndrome1
4Unknown StatusTreatmentCardiac Surgical Procedures / Cardiopulmonary Bypass / Systemic Inflammatory Response Syndrome (SIRS)1
4Unknown StatusTreatmentEndocrine ophthalmopathy1
4Unknown StatusTreatmentMastectomy / Neoplasms, Breast1
4Unknown StatusTreatmentTransplantation, Renal1
4WithdrawnNot AvailableAsthma Bronchial1
4WithdrawnTreatmentDemyelinating Disorders / Disseminated Sclerosis / Myelitis NOS / Neuritis / Optic Neuritis1
4WithdrawnTreatmentPediatric Crohn's Disease1
Not AvailableActive Not RecruitingTreatmentCongenital Heart Disease (CHD) / Disorder of Fetus or Newborn1
Not AvailableCompletedNot AvailableAutoimmune Encephalitis / Cognitive Impairments1
Not AvailableCompletedNot AvailableBlood Pressures / Graves Diseases / Graves Ophthalmopathy / Heart Failure, Unspecified / High Blood Pressure (Hypertension)1
Not AvailableCompletedNot AvailableCoagulation, Blood / Graves Ophthalmopathy / Graves' Disease / Venous Thromboembolism (VTE)1
Not AvailableCompletedNot AvailableCorticosteroid Injection / Shoulder Pain / Type2 Diabetes Mellitus1
Not AvailableCompletedNot AvailableDermatitis, Contact1
Not AvailableCompletedPreventionHeart Valve Diseases / Systemic Inflammatory Response Syndrome (SIRS)1
Not AvailableCompletedSupportive CareInflammatory Reaction / Postoperative pain1
Not AvailableCompletedSupportive CareOsteoarthritis (OA)1
Not AvailableCompletedSupportive CareOsteoarthritis (OA) / Post-traumatic; Arthrosis1
Not AvailableCompletedTreatmentAbdominal Aortic Aneurysms (AAA)1
Not AvailableCompletedTreatmentAortic Valve Stenosis1
Not AvailableCompletedTreatmentBack Pain Lower Back Chronic1
Not AvailableCompletedTreatmentBiliary Atresia1
Not AvailableCompletedTreatmentChronic Myeloproliferative Disorders / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases1
Not AvailableCompletedTreatmentCongenital Heart Disease (CHD) / Disorder of Fetus or Newborn1
Not AvailableCompletedTreatmentDisc Disease1
Not AvailableCompletedTreatmentEdema / Pain NOS / Trismus1
Not AvailableCompletedTreatmentEnd-Stage Renal Disease (ESRD)1
Not AvailableCompletedTreatmentHand, Foot, and Mouth Disease1
Not AvailableCompletedTreatmentLeukemias1
Not AvailableCompletedTreatmentLeukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Nonmalignant Neoplasm / Unspecified Adult Solid Tumor, Protocol Specific1
Not AvailableCompletedTreatmentPain, Chronic1
Not AvailableCompletedTreatmentShoulder Pain / Subacromial Bursitis1
Not AvailableCompletedTreatmentTransplantation, Kidney1
Not AvailableEnrolling by InvitationPreventionCervical Degenerative Disc Disease / Cervical Disc Herniation / Cervical Spondylotic Myelopathy / Osteoarthritis of Cervical Spine / Swallowing Disorders1
Not AvailableNot Yet RecruitingPreventionAortic Dissection1
Not AvailableNot Yet RecruitingTreatmentAlcoholic Hepatitis (AH)1
Not AvailableNot Yet RecruitingTreatmentHenoch-Schönlein Purpura1
Not AvailableRecruitingNot AvailableAcute Bacterial Exacerbation of Chronic Bronchitis (ABECB) / Acute Bacterial Sinusitis (ABS) / Acute Decompensated Heart Failure (ADHF) / Acute Pyelonephritis / Adenovirus / Adjunct to general anesthesia therapy / Adrenal Insufficiency / Airway Swelling / Anaesthesia therapy / Anxiolysis / Arterial Hypotension / Autism, Early Infantile / Autistic Disorder / Bartonellosis / Benzodiazepine Withdrawal / Benzodiazepines / Bipolar Disorder (BD) / Bloodstream Infections / Bone and Joint Infections / Brain Swelling / Bronchospasm / Brucellosis / Cardiac Arrest / Central Nervous System Infections / Cholera / Chronic Bacterial Prostatitis / Community Acquired Pneumonia (CAP) / Complicated Urinary Tract Infections / Convulsions / Cytomegalovirus Retinitis / Drug hypersensitivity reaction / Early-onset Schizophrenia Spectrum Disorders / Edema / Epilepsies / Feeling Anxious / Flu caused by Influenza / Gastroparesis / Gynaecological infection / Headaches / Herpes Simplex Virus / High Blood Pressure (Hypertension) / High Cholesterol / Hospital-acquired bacterial pneumonia / Hyperlipidemias / Infantile Hemangiomas / Infection NOS / Inflammatory Conditions / Inflammatory Reaction / Influenza Treatment or Prophylaxis / Inhalational Anthrax (Post-Exposure) / Intra-Abdominal Infections / Life-threatening Fungal Infections / Lower Respiratory Tract Infection (LRTI) / Meningitis, Bacterial / Migraines / Muscle Spasms / Nausea / Opioid Addiction / Pain NOS / Plague / Pneumonia / Prophylaxis / Psittacosis / Q Fever / Reflux / Relapsing Fever / Rocky Mountain Spotted Fever / Schizophrenic Disorders / Sedation therapy / Seizures / Sepsis / Skeletal Muscle Spasms / Skin and Subcutaneous Tissue Bacterial Infections / Skin Structures and Soft Tissue Infections / Stable Angina (SA) / Thromboprophylaxis / Thrombotic events / Toxic effect of hydrocyanic acid and cyanides / Trachoma / Treatment-resistant Schizophrenia / Tularemia / Typhus Fever / Uncomplicated Skin and Skin Structure Infections / Uncomplicated Urinary Tract Infections / Urinary Tract Infections (UTIs) / Vomiting / Withdrawal1
Not AvailableRecruitingNot AvailableAcute Exacerbation of Chronic Obstructive Pulmonary Disease / Alveolar Hypoventilation / Chronic Obstructive Pulmonary Disease (COPD) / Copd Exacerbation Acute / Emphysema or COPD / Respiratory Failure1
Not AvailableRecruitingNot AvailableAsthma Bronchial1
Not AvailableRecruitingNot AvailableChronic Renal Failure (CRF)1
Not AvailableRecruitingNot AvailableGraves Ophthalmopathy1
Not AvailableRecruitingTreatmentBiceps Tendonitis / Injections1
Not AvailableRecruitingTreatmentCarpal Tunnel Syndrome (CTS) / Pain, Chronic / Scleroderma1
Not AvailableRecruitingTreatmentChildhood Acute Lymphoblastic Leukemia1
Not AvailableRecruitingTreatmentChronic Renal Failure (CRF)1
Not AvailableRecruitingTreatmentDisorder Related to Renal Transplantation / Effects of Immunosuppressant Therapy1
Not AvailableRecruitingTreatmentIgA Glomerulonephritis1
Not AvailableRecruitingTreatmentImmunosuppression1
Not AvailableRecruitingTreatmentKnee Arthropathy1
Not AvailableRecruitingTreatmentMycoplasma Pneumoniae Pneumonia1
Not AvailableRecruitingTreatmentNeuroma, Human Forefoot1
Not AvailableRecruitingTreatmentOsteoarthritis of the Glenohumeral Joint1
Not AvailableRecruitingTreatmentPneumonia, Pneumocystis1
Not AvailableRecruitingTreatmentSystemic Lupus Erythematosus (SLE)1
Not AvailableRecruitingTreatmentTraumatic Optic Neuropathy1
Not AvailableRecruitingTreatmentVentral Hernias1
Not AvailableTerminatedOtherLumbar Back Pain / Lumbar Radiculitis / Lumbar Spine Disc Herniation1
Not AvailableTerminatedTreatmentAcute Respiratory Distress Syndrome (ARDS)1
Not AvailableTerminatedTreatmentBruton's agammaglobulinemia / Chediak-Higashi Syndrome / Chronic Granulomatous Disease (CGD) / Common Variable Immunodeficiency / Familial Erythrophagocytic Lymphohistiocytosis / Graft Versus Host Disease (GVHD) / Immunologic Deficiency Syndromes / Leukocyte Adhesion Deficiency Syndrome / Lymphohistiocytosis, Hemophagocytic / Severe Combined Immunodeficiency / Virus-Associated Hemophagocytic Syndrome / Wiskott-Aldrich Syndrome (WAS) / X-Linked Hyper IgM Syndrome / X-Linked Lymphoproliferative Syndrome1
Not AvailableTerminatedTreatmentChronic Myeloproliferative Disorders / Congenital Hypoplastic Anemia / Graft Versus Host Disease (GVHD) / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes / Myelodysplastic/Myeloproliferative Diseases1
Not AvailableTerminatedTreatmentDisseminated Sclerosis1
Not AvailableTerminatedTreatmentGraft Versus Host Disease (GVHD) / Leukemias / Malignant Lymphomas / Multiple Myeloma and Plasma Cell Neoplasm / Myelodysplastic Syndromes1
Not AvailableTerminatedTreatmentGraft Versus Host Disease, Acute1
Not AvailableTerminatedTreatmentInflammatory Bowel Diseases (IBD)1
Not AvailableTerminatedTreatmentRefractory Mycoplasma Pneumoniae Pneumonia1
Not AvailableTerminatedTreatmentShoulder Impingement Syndrome1
Not AvailableUnknown StatusPreventionLeukemias1
Not AvailableUnknown StatusTreatmentAnemia, Hemolytic, Autoimmune / Autoimmune Thrombocytopenic Purpura / Churg-Strauss Syndrome (CSS) / Giant Cells Arteritis / Graft Versus Host Disease (GVHD) / Granulomatosis With Polyangiitis / Polyarteritis Nodosa / Pure Red Cell Aplasia / Purpura, Schoenlein-Henoch / Rheumatoid Arthritis / Rheumatoid Arthritis, Juvenile / Systemic Lupus Erythematosus (SLE) / Takayasu's Disease / Vasculitis, Hypersensitivity1
Not AvailableUnknown StatusTreatmentAplastic Anaemia (AA) / Graft Versus Host Disease (GVHD)1
Not AvailableUnknown StatusTreatmentCarpal Tunnel Syndrome (CTS)1
Not AvailableUnknown StatusTreatmentChronic Obstructive Pulmonary Disease (COPD)2
Not AvailableUnknown StatusTreatmentDisseminated Sclerosis / Optic Neuritis1
Not AvailableUnknown StatusTreatmentKnee Osteoarthritis (Knee OA)1
Not AvailableUnknown StatusTreatmentSevere Acute Exacerbation of Chronic Hepatitis B1
Not AvailableWithdrawnDiagnosticLung Cancers1
Not AvailableWithdrawnTreatmentBronchiolitis1
Not AvailableWithdrawnTreatmentDexamethasone / Hiccups1

Pharmacoeconomics

Manufacturers
  • Pharmacia and upjohn co
  • Cadista pharmaceuticals inc
  • Duramed pharmaceuticals inc sub barr laboratories inc
  • Heather drug co inc
  • Par pharmaceutical inc
  • Sandoz inc
  • Vintage pharmaceuticals inc
  • Watson laboratories inc
  • Abbott laboratories hosp products div
  • Hemopharm usa corp
  • Hospira inc
  • Elkins sinn div ah robins co inc
  • Organon usa inc
  • Abraxis pharmaceutical products
  • App pharmaceuticals llc
  • Bedford laboratories
  • International medication systems ltd
  • Teva parenteral medicines inc
Packagers
  • Advanced Pharmaceutical Services Inc.
  • Aidarex Pharmacuticals LLC
  • Amerisource Health Services Corp.
  • Apotheca Inc.
  • APP Pharmaceuticals
  • A-S Medication Solutions LLC
  • Barr Pharmaceuticals
  • Bedford Labs
  • Breckenridge Pharmaceuticals
  • Bryant Ranch Prepack
  • C.O. Truxton Inc.
  • Cadista Pharmaceuticals Inc.
  • Cardinal Health
  • Carlisle Laboratories Inc.
  • Clint Pharmaceutical Inc.
  • DAVA Pharmaceuticals
  • Direct Dispensing Inc.
  • Dispensing Solutions
  • Diversified Healthcare Services Inc.
  • DRX Pharmaceuticals
  • General Injectables and Vaccines Inc.
  • Greenstone LLC
  • H.J. Harkins Co. Inc.
  • Hemofarm AD
  • Hospira Inc.
  • Innoviant Pharmacy Inc.
  • Keltman Pharmaceuticals Inc.
  • Major Pharmaceuticals
  • Mckesson Corp.
  • Medisca Inc.
  • Merrell Pharmaceuticals Inc.
  • Neuman Distributors Inc.
  • Nucare Pharmaceuticals Inc.
  • Palmetto Pharmaceuticals Inc.
  • Par Pharmaceuticals
  • Patheon Inc.
  • PD-Rx Pharmaceuticals Inc.
  • Pfizer Inc.
  • Pharmacia Inc.
  • Pharmedix
  • Physician Partners Ltd.
  • Physicians Total Care Inc.
  • Prasco Labs
  • Preferred Pharmaceuticals Inc.
  • Prescript Pharmaceuticals
  • Qualitest
  • Rebel Distributors Corp.
  • Redpharm Drug
  • San Jose Surgical Supply Inc.
  • Sandhills Packaging Inc.
  • Sandoz
  • Schein Pharmaceutical Inc.
  • Sicor Pharmaceuticals
  • Southwood Pharmaceuticals
  • Spectrum Pharmaceuticals
  • Stat Rx Usa
  • Vintage Pharmaceuticals Inc.
Dosage forms
FormRouteStrength
Injection, suspensionIntralesional; Intramuscular; Intrasynovial; Soft tissue20 mg/1mL
Injection, suspensionIntralesional; Intramuscular; Intrasynovial; Soft tissue40 mg/1mL
Injection, suspensionIntralesional; Intramuscular; Intrasynovial; Soft tissue80 mg/1mL
SuspensionIntra-articular; Intralesional; Intramuscular; Intrasynovial20 mg
SuspensionIntra-articular; Intralesional; Intramuscular; Intrasynovial80 mg
SuspensionIntra-articular; Intralesional; Intramuscular; Intrasynovial40 mg
SolutionIntra-articular; Intrabursal
KitEpidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Intravenous; Soft tissue; Subcutaneous; Topical
KitEpidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical
GelTopical10 mg/1g
KitInfiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue
Kit4 mg/1
TabletOral2 mg/1
TabletOral32 mg/1
TabletOral16 mg
TabletOral4 mg
CreamTopical2.5 mg
TabletOral16 mg/1
TabletOral4 mg/1
TabletOral8 mg/1
Injection, suspensionIntra-articular; Intralesional; Intramuscular; Parenteral; Soft tissue40 mg/1mL
Injection, suspensionIntra-articular; Intralesional; Intramuscular; Parenteral; Soft tissue80 mg/1mL
Injection, suspensionIntra-articular; Intralesional; Intramuscular; Soft tissue40 mg/1mL
Injection, suspensionIntra-articular; Intralesional; Intramuscular; Soft tissue80 mg/1mL
Injection, suspensionIntramuscular; Intrasynovial; Soft tissue40 mg/1mL
SuspensionIntra-articular; Intramuscular; Intrasynovial; Soft tissue40 mg
SuspensionIntra-articular; Intramuscular; Intrasynovial; Soft tissue80 mg
Powder, for solutionIntramuscular; Intravenous1 g
Powder, for solutionIntramuscular; Intravenous125 mg
Powder, for solutionIntramuscular; Intravenous40 mg
Powder, for solutionIntramuscular; Intravenous5 g
Powder, for solutionIntramuscular; Intravenous500 mg
Powder, for solutionIntramuscular; Intravenous
KitInfiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue; Topical
CreamTopical
LotionTopical
Kit
KitEpidural; Infiltration; Intramuscular; Intrasynovial; Soft tissue; Topical
KitInfiltration; Soft tissue; Topical
KitEpidural; Infiltration; Intracaudal
KitEpidural; Infiltration; Intra-articular; Intralesional; Intramuscular; Soft tissue
Kit; powderIntramuscular; Intravenous1 g
Kit; powderIntramuscular; Intravenous125 mg
Kit; powderIntramuscular; Intravenous40 mg
Kit; powderIntramuscular; Intravenous500 mg
Kit; powder, for solutionIntramuscular; Intravenous1 g
Kit; powder, for solutionIntramuscular; Intravenous125 mg
Kit; powder, for solutionIntramuscular; Intravenous40 mg
Kit; powder, for solutionIntramuscular; Intravenous500 mg
Prices
Unit descriptionCostUnit
Methylprednisolone powder96.25USD g
Methylprednisolone ac powdr40.09USD g
Methylprednisolone ss 1 gm vial31.2USD vial
Solu-medrol 1 gm vial24.43USD vial
Solu-medrol (pf) 500 mg vial20.9USD vial
MethylPREDNISolone (Pak) 21 4 mg tablet Disp Pack16.99USD disp
Methylprednisolone 500 mg vial15.6USD vial
Solu-medrol 500 mg vial12.9USD vial
Depo-medrol 80 mg/ml vial11.67USD ml
Methylprednisolone 125 mg vial10.0USD vial
Methylprednisolone 80 mg/ml vial9.12USD ml
Depo-medrol 40 mg/ml vial6.41USD ml
Solu-medrol (pf) 125 mg vial5.83USD vial
Methylprednisolone 40 mg/ml vial5.22USD ml
Medrol 32 mg tablet5.13USD tablet
Methylprednisolone 32 mg tablet4.62USD tablet
Depo-medrol 20 mg/ml vial3.78USD ml
Methylprednisolone 16 mg tablet3.17USD tablet
Methylprednisolone 40 mg vial3.0USD vial
A-methapred 40 mg vial2.36USD vial
Medrol 16 mg tablet2.28USD tablet
Medrol 8 mg tablet2.23USD tablet
Methylprednisolone 8 mg tablet1.74USD tablet
Methylprednisolone 4 mg tablet1.68USD tablet
Medrol 4 mg dosepak1.59USD each
Medrol 4 mg tablet0.99USD tablet
Medrol 2 mg tablet0.84USD tablet
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)232.5 °CPhysProp
water solubility120 mg/L (at 25 °C)YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP1.5Not Available
logS-2.99ADME Research, USCD
Predicted Properties
PropertyValueSource
Water Solubility0.109 mg/mLALOGPS
logP2.06ALOGPS
logP1.56ChemAxon
logS-3.5ALOGPS
pKa (Strongest Acidic)12.59ChemAxon
pKa (Strongest Basic)-2.9ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area94.83 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity103.04 m3·mol-1ChemAxon
Polarizability40.77 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9911
Blood Brain Barrier+0.9484
Caco-2 permeable-0.6404
P-glycoprotein substrateSubstrate0.7812
P-glycoprotein inhibitor INon-inhibitor0.7489
P-glycoprotein inhibitor IINon-inhibitor0.604
Renal organic cation transporterNon-inhibitor0.769
CYP450 2C9 substrateNon-substrate0.8415
CYP450 2D6 substrateNon-substrate0.9115
CYP450 3A4 substrateSubstrate0.7582
CYP450 1A2 substrateNon-inhibitor0.9473
CYP450 2C9 inhibitorNon-inhibitor0.907
CYP450 2D6 inhibitorNon-inhibitor0.9513
CYP450 2C19 inhibitorNon-inhibitor0.9026
CYP450 3A4 inhibitorNon-inhibitor0.8309
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9167
Ames testNon AMES toxic0.9337
CarcinogenicityNon-carcinogens0.9529
BiodegradationNot ready biodegradable0.9492
Rat acute toxicity2.0025 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9459
hERG inhibition (predictor II)Non-inhibitor0.5985
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-qTof , PositiveLC-MS/MSNot Available
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0a6r-0019000000-3a4955cf7cc34e1e8d0f
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-0k9i-0696000000-003c4527b983cf71aefd
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-01p9-0980000000-e5097669b38e84057a0f
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-01p9-0960000000-ef914702163187cc80af
LC-MS/MS Spectrum - LC-ESI-QTOF , positiveLC-MS/MSsplash10-06y9-0940000000-54b01b6c04c68be3f1b3
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0a4i-0009000000-3fe2869617af3697e2ed
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0a4i-0009000000-8ad4f169606968256614
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0f79-0895000000-29d1cbf49bb2b32c5a98
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-01p9-0940000000-baa402ac94c228229ea2
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-01p9-0910000000-5cf9fb219d798a9316f4
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0a4r-0910000000-a2d2af7f573229dc3147
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0006-2900000000-a01d5bfe926dc48e6e4c
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0a4i-0019000000-11519ee9583104c00505
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0gw0-0974000000-af5d4ebce055ce6efb23
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-01p9-0960000000-22e2342fcec2bf1cd833
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-01p9-0920000000-63759535c53af1efb13f
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0c09-1900000000-a48c07db31cf27cf0381
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-05tp-2900000000-b802f5e17b69cd6c707f
LC-MS/MS Spectrum - LC-ESI-ITFT , positiveLC-MS/MSsplash10-0a4i-0009000000-0e0cc8bfc7721357c5cf
MS/MS Spectrum - , positiveLC-MS/MSsplash10-0bti-0896000000-86854a3fa2cb3c3bde0b
MS/MS Spectrum - , positiveLC-MS/MSsplash10-0a4r-0796000000-b0070da713077c3f7975
MS/MS Spectrum - , positiveLC-MS/MSsplash10-01p9-3950000000-b938f656c358e1e42bb5

Taxonomy

Description
This compound belongs to the class of organic compounds known as 21-hydroxysteroids. These are steroids carrying a hydroxyl group at the 21-position of the steroid backbone.
Kingdom
Organic compounds
Super Class
Lipids and lipid-like molecules
Class
Steroids and steroid derivatives
Sub Class
Hydroxysteroids
Direct Parent
21-hydroxysteroids
Alternative Parents
Gluco/mineralocorticoids, progestogins and derivatives / 20-oxosteroids / 3-oxo delta-1,4-steroids / 17-hydroxysteroids / 11-beta-hydroxysteroids / Delta-1,4-steroids / Tertiary alcohols / Alpha-hydroxy ketones / Secondary alcohols / Cyclic ketones
show 4 more
Substituents
Progestogin-skeleton / 21-hydroxysteroid / 20-oxosteroid / Pregnane-skeleton / 3-oxo-delta-1,4-steroid / 3-oxosteroid / Oxosteroid / 11-beta-hydroxysteroid / 11-hydroxysteroid / 17-hydroxysteroid
show 15 more
Molecular Framework
Aliphatic homopolycyclic compounds
External Descriptors
6-methylprednisolone (CHEBI:6888) / C21 steroids (gluco/mineralocorticoids, progestogins) and derivatives (LMST02030178)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Yes
Actions
Agonist
General Function
Zinc ion binding
Specific Function
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modula...
Gene Name
NR3C1
Uniprot ID
P04150
Uniprot Name
Glucocorticoid receptor
Molecular Weight
85658.57 Da
References
  1. Owen HC, Miner JN, Ahmed SF, Farquharson C: The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438. Mol Cell Endocrinol. 2007 Jan 29;264(1-2):164-70. Epub 2006 Dec 19. [PubMed:17182172]
  2. Juruena MF, Cleare AJ, Papadopoulos AS, Poon L, Lightman S, Pariante CM: Different responses to dexamethasone and prednisolone in the same depressed patients. Psychopharmacology (Berl). 2006 Dec;189(2):225-35. Epub 2006 Oct 3. [PubMed:17016711]
  3. Boivin MA, Ye D, Kennedy JC, Al-Sadi R, Shepela C, Ma TY: Mechanism of glucocorticoid regulation of the intestinal tight junction barrier. Am J Physiol Gastrointest Liver Physiol. 2007 Feb;292(2):G590-8. Epub 2006 Oct 26. [PubMed:17068119]
  4. Quesnell RR, Han X, Schultz BD: Glucocorticoids stimulate ENaC upregulation in bovine mammary epithelium. Am J Physiol Cell Physiol. 2007 May;292(5):C1739-45. Epub 2007 Jan 24. [PubMed:17251323]
  5. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352]

Enzymes

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
Inducer
General Function
Vitamin d3 25-hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation react...
Gene Name
CYP3A4
Uniprot ID
P08684
Uniprot Name
Cytochrome P450 3A4
Molecular Weight
57342.67 Da
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256]
  2. Litt J. (2016). Litt's Drug eruption & reaction manual (22nd ed.). CRC Press LLc.

Transporters

Kind
Protein
Organism
Human
Pharmacological action
Unknown
Actions
Substrate
General Function
Xenobiotic-transporting atpase activity
Specific Function
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Gene Name
ABCB1
Uniprot ID
P08183
Uniprot Name
Multidrug resistance protein 1
Molecular Weight
141477.255 Da
References
  1. Oka A, Oda M, Saitoh H, Nakayama A, Takada M, Aungst BJ: Secretory transport of methylprednisolone possibly mediated by P-glycoprotein in Caco-2 cells. Biol Pharm Bull. 2002 Mar;25(3):393-6. [PubMed:11913542]
  2. Troutman MD, Thakker DR: Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium. Pharm Res. 2003 Aug;20(8):1210-24. [PubMed:12948019]
  3. Yates CR, Chang C, Kearbey JD, Yasuda K, Schuetz EG, Miller DD, Dalton JT, Swaan PW: Structural determinants of P-glycoprotein-mediated transport of glucocorticoids. Pharm Res. 2003 Nov;20(11):1794-803. [PubMed:14661924]

Drug created on June 13, 2005 07:24 / Updated on December 18, 2018 05:46