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Displaying drugs 326 - 350 of 13635 in total

Poliovirus type 1 antigen (formaldehyde inactivated)

Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were...
Approved
Investigational
Matched Description: … Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization ... of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused ... The vaccine contains purified and inactivated poliovirus type 1 that were grown from a continuous line …
Matched Mixtures name: … -POLIO SUSPENSION FOR INJECTION IN PRE-FILLED SYRINGE ... Hexaxim Suspension for Injection ... BOOSTRIX POLIO SUSPENSION FOR INJECTION …

Estradiol acetate

Estradiol acetate is a pro-drug ester of DB00783, a naturally occurring hormone that circulates endogenously within the human body. Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex hormone. As a pro-drug of estradiol, estradiol acetate therefore has the same downstream...
Approved
Investigational
Vet approved
Matched Iupac: … (1S,3aS,3bR,9bS,11aS)-1-hydroxy-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthren …
Matched Description: … Estradiol acetate is commercially available as Femring, a vaginal ring used for the treatment of moderate ... Because of the difference in potency between estradiol and estrone, menopause (and a change in primary ... Estradiol is the most potent form of all mammalian estrogenic steroids and acts as the major female sex …

Burosumab

Burosumab (KRN23) is an entirely human monoclonal IgG1 antibody that binds excess fibroblast growth factor 23 (FGF23) and has been successfully tested in clinical trials in children with X-linked hypophosphatemic rickets . The U.S. Food and Drug Administration approved Crysvita (burosumab) in April 2018. This is the first drug approved...
Approved
Investigational
Matched Description: … X-linked hypophosphatemia causes low circulating levels of phosphorus in the blood. ... XLH is a serious disease which affects about 3,000 children and 12,000 adults in the United States. ... throughout a patient’s life [L2346]. …
Matched Categories: … Drugs for Treatment of Bone Diseases …
Matched Products: … CRYSVITA® SOLUTION FOR INJECTION 10 MG/ML ... CRYSVITA® SOLUTION FOR INJECTION 30 MG/ML ... CRYSVITA® SOLUTION FOR INJECTION 20 MG/ML …

Fezolinetant

Vasomotor symptoms (VMS), more colloquially known as hot flashes or night sweats, are some of the most common symptoms in menopause. With a median duration of 7.4 years, vasomotor symptoms are also the most common reasons why women seek treatments for menopausal issues.[A259591,A259596] Although mostly considered a nuisance, vasomotor symptoms...
Approved
Investigational
Matched Iupac: … 5-[(8R)-7-(4-fluorobenzoyl)-8-methyl-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-3-yl]-3-methyl-1,2,4-thiadiazole …
Matched Description: … effective treatments for VMS by relieving symptoms in as many as 95% of menopausal women. ... [L46422] It was subsequently approved by the EMA in December 2023 for the same indication.[L50086] ... quality of life, as women with 7 or more moderate to severe VMS daily have reported a decline in sleep …

Saxagliptin

Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009.
Approved
Matched Categories: … Drugs Used in Diabetes …

Busulfan

Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow. It is not a structural analog of the nitrogen mustards. It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), but although symptomatic relief is provided, no permanent remission is brought...
Approved
Investigational
Matched Description: … It has been used in the palliative treatment of chronic myeloid leukemia (myeloid leukemia, chronic), ... Busulfan is a bifunctional alkylating agent, having a selective immunosuppressive effect on bone marrow ... It is not a structural analog of the nitrogen mustards. …
Matched Categories: … Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Matched Products: … Busulfan Kabi Injection 6mg/ml Concentrate for Solution for Infusion ... Busulfan for Injection …

Edetic acid

A chelating agent (chelating agents) that sequesters a variety of polyvalent cations. It is used in pharmaceutical manufacturing and as a food additive.
Approved
Vet approved
Matched Description: … It is used in pharmaceutical manufacturing and as a food additive. ... A chelating agent (chelating agents) that sequesters a variety of polyvalent cations. …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Poliovirus type 2 antigen (formaldehyde inactivated)

Poliovirus type 2 antigen is a suspension of poliovirus Type 2 (MEF-1) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 2. The vaccine contains purified and inactivated poliovirus type 2 that were...
Approved
Investigational
Matched Description: … Poliovirus type 2 antigen is a suspension of poliovirus Type 2 (MEF-1) used in the active immunization ... of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused ... The vaccine contains purified and inactivated poliovirus type 2 that were grown from a continuous line …
Matched Mixtures name: … -POLIO SUSPENSION FOR INJECTION IN PRE-FILLED SYRINGE ... Hexaxim Suspension for Injection ... BOOSTRIX POLIO SUSPENSION FOR INJECTION …

Iodine

Iodine is commonly used as an antiseptic for minor cuts and abrasions, preventing infections that may result from contaminated wounds. Additionally, iodine has been studied in the treatment of fibrocystic disease and breast cancer.[A3413,A192153,A192156,A192159]
Approved
Investigational
Matched Description: … Iodine is commonly used as an antiseptic for minor cuts and abrasions, preventing infections that may ... Additionally, iodine has been studied in the treatment of fibrocystic disease and breast cancer. …
Matched Mixtures name: … For-2 ... One A Day Tab ... Complete One A Day Tab …
Matched Products: … XENETIX 350-50ML SOLN FOR INTRAVASCULAR INJ ... XENETIX 300-50ML SOLN FOR INTRAVASCULAR INJ ... XENETIX 350-100ML SOLN FOR INTRAVASCULAR INJ …

Levetiracetam

Levetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures stemming from epileptic disorders. It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated to other anti-epileptic drugs (AEDs).[L8606,L8600,L8615] Levetiracetam possesses a wide therapeutic index[L8615,A185918]...
Approved
Matched Description: … indexes and a propensity for involvement in drug interactions. ... It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated ... desirable choice over other AEDs, a class of drugs notorious for having generally narrow therapeutic …
Matched Products: … Levetiracetam in Sodium Chloride ... Keppra Concentrate for Solution for Infusion 500 mg/5ml ... Keppra Concentrate for Solution for Infusion 100 mg/ml …

Peginterferon beta-1a

Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years of...
Approved
Matched Description: … It was originally approved by the FDA in 2014 for subcutaneous use, and was approved for intramuscular ... Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system ... occur more frequently in women than in men. …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Latanoprost

Latanoprost is a prodrug analog of prostaglandin F2 alpha that is used to treat elevated intraocular pressure (IOP). It was initially approved by the FDA in 1998. Latanoprost is the first topical prostaglandin F2 alpha analog used for glaucoma treatment. It has been found to be well-tolerated and its use...
Approved
Investigational
Matched Description: … Latanoprost is the first topical prostaglandin F2 alpha analog used for glaucoma treatment. ... It was initially approved by the FDA in 1998. ... Another benefit latanoprost is that it can be administered once a day.[A184490] …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Crotamiton

Crotamiton is a scabicidal and antipruritic agent available as a cream or lotion for topical use only. It is a colorless to slightly yellowish oil, having a faint amine-like odor. It is miscible with alcohol and with methanol.
Approved
Matched Description: … Crotamiton is a scabicidal and antipruritic agent available as a cream or lotion for topical use only ... It is a colorless to slightly yellowish oil, having a faint amine-like odor. …
Matched Categories: … Compounds used in a research, industrial, or household setting …
Matched Products: … A-Bite Cream …

Padeliporfin

Padeliporfin is a water-soluble chlorophyll derivative and cytotoxic photosensitizer used for vascular-targeted photodynamic therapy for malignancies. Vascular-targeted photodynamic therapy (VTP), or vascular targeted photochemotherapy, is a focal treatment for localized prostate cancer. It aims to destroy only cancerous lesions of the prostate, rather than ablating the entire prostate gland. Padeliporfin...
Approved
Experimental
Matched Description: … Padeliporfin is a water-soluble chlorophyll derivative and cytotoxic photosensitizer used for vascular-targeted ... of low-risk prostate cancer in adults meeting certain clinical criteria. ... [A244559] Vascular-targeted photodynamic therapy (VTP), or vascular targeted photochemotherapy, is a …
Matched Categories: … Sensitizers Used in Photodynamic/radiation Therapy …

Durvalumab

Durvalumab is a human immunoglobulin G1 kappa (IgG1κ) monoclonal antibody and a novel immune-checkpoint inhibitor for cancer treatment. Produced by recombinant DNA technology in Chinese Hamster Ovary (CHO) cell suspension culture, durvalumab is a programmed death-ligand 1 (PD-L1) blocking antibody that works to promote normal immune responses that attack tumour...
Approved
Investigational
Matched Description: … [L12621] In September 2018, durvalumab was approved by the EMA for the treatment of adult patients with ... It was granted accelerated approval by the FDA in May 2017 [A192807] for the treatment of selected patients ... [A192789,L12627] On March 27, 2020, durvalumab was approved by the FDA for use in combination with [etoposide …
Matched Products: … IMFINZI CONCENTRATE FOR SOLUTION FOR INFUSION 50 MG/ML ... IMFINZI CONCENTRATE FOR SOLUTION FOR INTRAVENOUS INFUSION 50 MG/ML …

Carbon monoxide

Carbon monoxide (CO) is a colorless, odorless, and tasteless gas that has a slightly lower density than air. It is toxic to hemoglobin utilizing animals (including humans), when encountered in concentrations above about 35 ppm, although it is also formed in normal animal metabolism in low quantities, and is thought...
Approved
Investigational
Matched Description: … A test of the diffusing capacity of the lungs for carbon monoxide (DLCO), is one of the most clinically ... Since 2002, FDA has favorably reviewed three GRAS notifications for carbon monoxide use in fresh meat ... This use of CO has been generally recognized as safe (GRAS) in several packaging applications for fresh …

Sparsentan

Sparsentan is a dual antagonist of the endothelin type A receptor (ETAR) and the angiotensin II (Ang II) type 1 receptor (AT1R) with a similar affinity for both (9.3 nM for ETAR and 0.8 nM for AT1R).[A257330,L45300] Sparsentan is first in its class and orally active, and was created by...
Approved
Investigational
Matched Description: … II (Ang II) type 1 receptor (AT1R) with a similar affinity for both (9.3 nM for ETA< ... Furthermore, it is the first non-immunosuppressive therapy for the reduction of proteinuria in IgAN. ... /sub>R and 0.8 nM for AT1R). …
Matched Categories: … Dual Endothelin Type A Receptor/Ang II Subtype 1 Receptor Antagonist (DEARA) …

Pidolic acid

Pidolic acid is a naturally occurring but little-studied amino acid derivative that can be formed enzymatically or non-enzymatically and participates as a biological intermediate with unique pharmacodynamics in various chemical pathways [A32991, L2729]. Elevations of the acid in blood levels may be associated with problems of glutamine or glutathione metabolism...
Approved
Investigational
Matched Description: … Elevations of the acid in blood levels may be associated with problems of glutamine or glutathione metabolism ... or non-enzymatically and participates as a biological intermediate with unique pharmacodynamics in various ... Although pidolic acid is included in some over-the-counter, non-prescription dietary supplements for …

Sotalol

Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening...
Approved
Matched Description: … Sotalol is a methanesulfonanilide developed in 1960. ... in atrial fibrillation or flutter. ... injection indicated for life threatening ventricular arrhythmias and maintaining normal sinus rhythm …
Matched Categories: … Medications that reduce magnesium levels ... Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index …

Amoxapine

Amoxapine, the N-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, amoxapine does not affect mood or arousal, but may cause sedation....
Approved
Matched Description: … See toxicity section below for a complete listing of side effects. ... In depressed individuals, amoxapine exerts a positive effect on mood. ... receptors, α1-adrenergic receptors and muscarinic receptors, which accounts for …
Matched Categories: … Antidepressive Agents Indicated for Depression ... Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index …

Hydrocortisone acetate

Approved
Vet approved
Matched Iupac: … 1,10-dihydroxy-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a] …
Matched Mixtures name: … Alcortin A ... Alcortin A …
Matched Products: … Poli-A …

Aclidinium

Aclidinium is an anticholinergic for the long-term management of chronic obstructive pulmonary disease (COPD). It has a much higher propensity to bind to muscarinic receptors than nicotinic receptors. FDA approved on July 24, 2012.
Approved
Matched Description: … It has a much higher propensity to bind to muscarinic receptors than nicotinic receptors. ... Aclidinium is an anticholinergic for the long-term management of chronic obstructive pulmonary disease …
Matched Categories: … Drugs for Obstructive Airway Diseases …

Apraclonidine

Apraclonidine, also known as iopidine, is a sympathomimetic used in glaucoma therapy. It is an alpha2-adrenergic agonist.
Approved
Matched Description: … Apraclonidine, also known as iopidine, is a sympathomimetic used in glaucoma therapy. …
Matched Categories: … Sympathomimetics in Glaucoma Therapy …

Omega-3-carboxylic acids

The omega-3 carboxylic acid (OM3-CA) is a new formulation of omega-3 fatty acids that present an enhanced bioavailability in the treatment of dyslipidemia. The increased bioavailability is explained because OM3-CA is found in a form of polyunsaturated free fatty acids as opposed to other products whose form is as ethyl...
Approved
Investigational
Matched Description: … acid as the most abundant species found in a proportion of 55% and 20% respectively. ... The increased bioavailability is explained because OM3-CA is found in a form of polyunsaturated free ... bioavailability in the treatment of dyslipidemia. …

Procaine benzylpenicillin

Procaine benzylpenicillin (INN), also known as procaine G penicillin, is an injectable antiobiotic. It is a poorly soluble salt form of penicillin which is a combination of naturally occuring benzylpenicillin (penicillin G) and the local anaesthetic agent procaine in equimolar amounts. Procaine benzylpenicillin is administered by deep intramuscular injection. It...
Approved
Vet approved
Matched Description: … Benzylpenicillin is active against a wide range of organisms and is the drug of first choice for many ... It is widely used in veterinary settings. ... (penicillin G) and the local anaesthetic agent procaine in equimolar amounts. …
Matched Mixtures name: … Bicillin A-P Injection Pws …
Matched Categories: … Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …
Displaying drugs 326 - 350 of 13635 in total