Identification

Name
Iodine
Accession Number
DB05382  (DB05247)
Type
Small Molecule
Groups
Approved, Investigational
Description

Molecualar iodine has been developed by Symbollon Pharmaceuticals. It is a potential treatment for moderate to severe cyclic pain and tenderness (clinical mastalgia) associated with fibrocystic breast disease (FBD).

Structure
Thumb
Synonyms
  • diiodine
  • I2
  • iodo
  • Jod
  • molecular iodine
External IDs
NSC-42355
Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
EthiodolInjection475 mg/1mLIntralymphaticUNSPECIFIED2006-04-07Not applicableUs
Iodine Gauze PackingStrip5 %TopicalDumex Medical Canada Inc.Not applicableNot applicableCanada
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Alphadine ScrubSolution7.5 mg/100mLTopicalEcolab Inc.2000-02-052018-01-17Us
Colloidal IodineSolution2 g/100mLTopicalJCI INSTITUTE OF MEDICAL SCIENCE2014-08-27Not applicableUs
Colloidal Iodine OphthalmicSolution0.1 g/100mLTopicalJCI INSTITUTE OF MEDICAL SCIENCE2014-08-27Not applicableUs
Foam Care Pvp Iodophor Surg Hand Scrub 0.75%Liquid.75 %TopicalBallard Medical Products1990-12-312008-09-17Canada
Iodine SeppTincture20 mg/1mLTopicalCare Fusion 213 Llc1988-02-012016-11-06Us
Iodine Tab 3mgTablet3 mgOralTherapeutic Foods Co.1988-03-232009-07-24Canada
Iodine Tincture RojoSolution / drops20 mg/1mLTopicalDannso corp./d.b.a. Essential Products2015-08-08Not applicableUs
Iodine Tincture WhiteSolution / drops20 mg/1mLTopicalDannso corp./d.b.a. Essential Products2015-08-08Not applicableUs
JCI MN Colloidal Iodine Eye Wash Cleansing Water (Quasi Drug)Solution0.1 g/100mLTopicalJCI INSTITUTE OF MEDICAL SCIENCE2015-02-01Not applicableUs
JCI MN Colloidal Iodine Immune-improving WaterSolution2 g/100mLTopicalJCI INSTITUTE OF MEDICAL SCIENCE2015-01-27Not applicableUs
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Anaplex TabIodine (.05 mg) + Ascorbic acid (40 mg) + Calcium (160 mg) + Magnesium oxide (50 mg) + Nicotinamide (30 mg) + Calcium pantothenate (15 mg) + Phosphorus (75.33 mg) + Potassium Chloride (20 mg) + Pyridoxine hydrochloride (40 mg) + Vitamin A palmitate (2000 unit) + Vitamin D (133.33 unit)TabletOralAnabolic Laboratories Inc.1975-12-311996-10-02Canada
Blood Culture Prep KitIodine (20 mg/1mL) + Isopropyl Alcohol (0.7 mL/1mL)KitTopicalCare Fusion 213 Llc1988-02-012016-07-25Us
CVS IodineIodine (20 mg/1mL) + Ethanol (470 mg/1mL) + Sodium iodide (20.4 mg/1mL)LiquidTopicalCVS Health2008-01-01Not applicableUs
DDM Iodine Tincture MildIodine (20 mg/1mL) + Ethanol (470 mg/1mL) + Sodium iodide (20.4 mg/1mL)LiquidTopicalDiscount Drug Mart1979-01-01Not applicableUs
De La Cruz Tincture of IodineIodine (20 mg/1mL) + Ethanol (470 mg/1mL) + Sodium iodide (20.4 mg/1mL)LiquidTopicalDLC Laboratories, Inc.1979-01-01Not applicableUs
DiodineIodine (750 mg) + Isopropyl Alcohol (25.11 ml) + Potassium Iodide (750 mg)LiquidTopicalProduits Marc O (1987) Inc., Division Of Technilab Inc.1980-06-051999-09-17Canada
Donor Prep KitIodine (20 mg/1mL) + Isopropyl Alcohol (0.7 mL/1mL)KitCare Fusion 213 Llc1988-02-012012-01-31Us
GNP Idoinde Tincture 2% MildIodine (20 mg/1mL) + Ethanol (470 mg/1mL) + Sodium iodide (20.4 mg/1mL)LiquidTopicalAmerisource Bergen2008-01-01Not applicableUs
Harris Teeter Iodine Tincture MildIodine (20 mg/1mL) + Ethanol (470 mg/1mL) + Sodium iodide (20.4 mg/1mL)LiquidTopicalHarris Teeter1979-01-01Not applicableUs
Health Mart Iodine Tincture MildIodine (20 mg/1mL) + Ethanol (470 mg/1mL) + Sodium iodide (20.4 mg/1mL)LiquidTopicalMc Kesson2011-01-01Not applicableUs
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
Bal-Care DHAIodine (.223 mg/1) + Ascorbic acid (120 mg/1) + Beta carotene (2850 [iU]/1) + Calcium Carbonate (219 mg/1) + Cholecalciferol (840 [iU]/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (.012 mg/1) + DL-alpha tocopheryl acetate (3 mg/1) + Folic Acid (1 mg/1) + Iron saccharate (1.35 mg/1) + Magnesium oxide (25 mg/1) + Nicotinamide (20 mg/1) + Omega-3 fatty acids (430 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (4 mg/1) + Sodium feredetate (25.65 mg/1) + Thiamine mononitrate (1.8 mg/1) + Zinc oxide (25 mg/1)KitPru Gen Pharmaceuticals2012-05-01Not applicableUs
Bal-Care DHA EssentialIodine (.223 mg/1) + Ascorbic acid (120 mg/1) + Beta carotene (2850 [iU]/1) + Calcium Carbonate (219 mg/1) + Cholecalciferol (840 [iU]/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (.012 mg/1) + DL-alpha tocopheryl acetate (3 mg/1) + Folic Acid (1 mg/1) + Iron saccharate (1.35 mg/1) + Magnesium oxide (25 mg/1) + Nicotinamide (20 mg/1) + Omega-3 fatty acids (374 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (4 mg/1) + Sodium feredetate (25.65 mg/1) + Thiamine mononitrate (1.8 mg/1) + Zinc oxide (25 mg/1)KitPru Gen Pharmaceuticals2012-05-01Not applicableUs
Cavan AlphaIodine (220 ug/1) + Ascorbic acid (120 mg/1) + Beta carotene (3000 [iU]/1) + Calcium Carbonate (230 mg/1) + Cholecalciferol (800 [iU]/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (12 ug/1) + DL-alpha tocopheryl acetate (3 mg/1) + Folic Acid (1 mg/1) + Iron (27 mg/1) + Magnesium oxide (25 mg/1) + Nicotinamide (20 mg/1) + Omega-3 fatty acids (300 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (4 mg/1) + Thiamine mononitrate (1.8 mg/1) + Zinc oxide (25 mg/1)KitOralSeton Pharmaceuticals2010-07-012013-09-30Us
CitraNatal AssureIodine (150 ug/1) + Ascorbic acid (120 mg/1) + Calcium citrate tetrahydrate (124 mg/1) + Cholecalciferol (400 [iU]/1) + Copper (2 mg/1) + Doconexent (300 mg/1) + Docusate sodium (50 mg/1) + Folic Acid (1 mg/1) + Icosapent (0.75 mg/1) + Iron (35 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (3.4 mg/1) + Thiamine chloride (3 mg/1) + Vitamin E (30 [iU]/1) + Zinc (25 mg/1)KitMission Pharmacal Company2014-04-30Not applicableUs
CitraNatal AssureIodine (150 ug/1) + Ascorbic acid (120 mg/1) + Calcium citrate tetrahydrate (125 mg/1) + Cholecalciferol (400 [iU]/1) + Copper (2 mg/1) + Doconexent (300 mg/1) + Docusate sodium (50 mg/1) + Folic Acid (1 mg/1) + Icosapent (0.75 mg/1) + Iron (35 mg/1) + Nicotinamide (20 mg/1) + Pyridoxine hydrochloride (25 mg/1) + Riboflavin (3.4 mg/1) + Thiamine chloride (3 mg/1) + Vitamin E (30 [iU]/1) + Zinc (25 mg/1)KitMission Pharmacal2008-11-19Not applicableUs
Duet DHAIodine (220 ug/1) + Ascorbic acid (120 mg/1) + Beta carotene (2825 [iU]/1) + Calcium Carbonate (200 mg/1) + Cholecalciferol (800 [iU]/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (12 ug/1) + D-alpha-Tocopherol acetate (3 mg/1) + Folic Acid (1 mg/1) + Iron (25 mg/1) + Magnesium oxide (25 mg/1) + Nicotinamide (20 mg/1) + Omega-3 fatty acids (430 mg/1) + Pyridoxine hydrochloride (45 mg/1) + Riboflavin (4 mg/1) + Thiamine mononitrate (1.8 mg/1) + Zinc oxide (25 mg/1)KitOralWh Nutritionals, Llc2011-09-092014-03-31Us
Duet DHAIodine (220 ug/1) + Ascorbic acid (120 mg/1) + Beta carotene (2825 [iU]/1) + Calcium Carbonate (200 mg/1) + Cholecalciferol (800 [iU]/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (12 ug/1) + D-alpha-Tocopherol acetate (3 mg/1) + Folic Acid (1 mg/1) + Iron (25 mg/1) + Magnesium oxide (25 mg/1) + Nicotinamide (20 mg/1) + Omega-3 fatty acids (400 mg/1) + Pyridoxine hydrochloride (45 mg/1) + Riboflavin (4 mg/1) + Thiamine mononitrate (1.8 mg/1) + Zinc oxide (25 mg/1)KitOralWh Nutritionals, Llc2011-09-092014-03-31Us
Duet DHAIodine (220 ug/1) + Ascorbic acid (120 mg/1) + Beta carotene (2800 [iU]/1) + Calcium Carbonate (200 mg/1) + Cholecalciferol (820 [iU]/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (12 ug/1) + D-alpha-Tocopherol acetate (3 mg/1) + Folic Acid (1 mg/1) + Iron (25 mg/1) + Magnesium oxide (25 mg/1) + Nicotinamide (20 mg/1) + Omega-3 fatty acids (430 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (4 mg/1) + Thiamine mononitrate (1.8 mg/1) + Zinc oxide (25 mg/1)KitOralWh Nutritionals, Llc2011-09-092014-12-31Us
Duet DHAIodine (220 ug/1) + Ascorbic acid (120 mg/1) + Beta carotene (2800 [iU]/1) + Calcium Carbonate (200 mg/1) + Cholecalciferol (820 [iU]/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (12 ug/1) + D-alpha-Tocopherol acetate (3 mg/1) + Folic Acid (1 mg/1) + Iron (25 mg/1) + Magnesium oxide (25 mg/1) + Nicotinamide (20 mg/1) + Omega-3 fatty acids (400 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (4 mg/1) + Thiamine mononitrate (1.8 mg/1) + Zinc oxide (25 mg/1)KitOralWh Nutritionals, Llc2011-09-092014-12-31Us
Duet DHA 400Iodine (220 ug/1) + Ascorbic acid (120 mg/1) + Beta carotene (2800 [iU]/1) + Calcium Carbonate (200 mg/1) + Cholecalciferol (820 [iU]/1) + Cupric oxide (2 mg/1) + Cyanocobalamin (12 ug/1) + D-alpha-Tocopherol acetate (3 mg/1) + Folic Acid (1 mg/1) + Iron (25 mg/1) + Magnesium oxide (25 mg/1) + Nicotinamide (20 mg/1) + Omega-3 fatty acids (400 mg/1) + Pyridoxine hydrochloride (50 mg/1) + Riboflavin (4 mg/1) + Thiamine mononitrate (1.8 mg/1) + Zinc oxide (25 mg/1)KitOralEckson Labs, LLC2011-09-09Not applicableUs
International/Other Brands
IoGen
Categories
UNII
9679TC07X4
CAS number
7553-56-2
Weight
Average: 253.8089
Monoisotopic: 253.80893684
Chemical Formula
I2
InChI Key
PNDPGZBMCMUPRI-UHFFFAOYSA-N
InChI
InChI=1S/I2/c1-2
IUPAC Name
diiodane
SMILES
II

Pharmacology

Indication

Investigated for use/treatment in breast disorders (unspecified) and pain (acute or chronic).

Pharmacodynamics
Not Available
Mechanism of action

Molecular iodine is known to inhibit the induction and promotion of N-methyl-n-nitrosourea-induced mammary carcinogenesis, to regress 7,12-dimethylbenz(a)anthracene-induced breast tumors in rats.It has also been shown to have beneficial effects in fibrocystic human breast disease.

TargetActionsOrganism
UNADH-ubiquinone oxidoreductase chain 5Not AvailableHuman
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity
Not Available
Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
Not Available
Food Interactions
Not Available

References

General References
  1. Shrivastava A, Tiwari M, Sinha RA, Kumar A, Balapure AK, Bajpai VK, Sharma R, Mitra K, Tandon A, Godbole MM: Molecular iodine induces caspase-independent apoptosis in human breast carcinoma cells involving the mitochondria-mediated pathway. J Biol Chem. 2006 Jul 14;281(28):19762-71. Epub 2006 May 5. [PubMed:16679319]
External Links
Human Metabolome Database
HMDB0000675
KEGG Drug
D00108
KEGG Compound
C01382
PubChem Compound
807
PubChem Substance
175426989
ChemSpider
785
ChEBI
17606
ChEMBL
CHEMBL1201225
HET
I2I
Wikipedia
Iodine
ATC Codes
D08AG03 — Iodine
AHFS Codes
  • 92:01.00* — Herbs and Natural Products
  • 88:29.00* — Minerals
  • 84:04.92 — Miscellaneous Local Anti-infectives
PDB Entries
4r1t

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2RecruitingTreatmentCancer, Breast1
3CompletedPreventionCariostatic Agents / Dental Decay1
3CompletedTreatmentDental Plaque1
3Unknown StatusTreatmentFibrocystic Changes of Breast / Fibrocystic Disease of Breast / Fibrocystic Mastopathy / Pain NOS1
4CompletedDiagnosticCoronary Artery Disease / Coronary Stenosis1
4CompletedTreatmentSkin Diseases, Infectious / Soft Tissues Infections1
4RecruitingPreventionHysterectomy1
4Unknown StatusTreatmentAmputation Wound / Wound Infections1
Not AvailableCompletedPreventionBacteremia1
Not AvailableRecruitingTreatmentRoot Canal Disinfection1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
SolutionTopical7.5 mg/100mL
KitTopical
Kit
SolutionTopical0.1 g/100mL
LiquidTopical
KitOral
InjectionIntralymphatic475 mg/1mL
LiquidTopical.75 %
LiquidOral
SolutionTopical
StripTopical5 %
TinctureTopical20 mg/1mL
TabletOral3 mg
Solution / dropsTopical
SprayTopical
TinctureTopical
Solution / dropsTopical20 mg/1mL
SolutionTopical2 g/100mL
TabletOral.3 mg
TabletOral150 mcg
TabletOral
LiquidOral.15 mg
LiquidTopical0.4 g/1g
LiquidTopical1 %
Aerosol, sprayTopical0.1 g/1g
Tablet, film coatedOral
Capsule, gelatin coatedOral
LiquidIntravenous
LiquidOral2.5 g/100mL
LiquidTopical5 %
CapsuleOral
LiquidVaginal1 %
Tablet, coatedOral
Capsule, liquid filledOral
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
logP1.36ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity26.68 m3·mol-1ChemAxon
Polarizability10.18 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET features
PropertyValueProbability
Human Intestinal Absorption+0.9789
Blood Brain Barrier+0.9786
Caco-2 permeable+0.6632
P-glycoprotein substrateNon-substrate0.8984
P-glycoprotein inhibitor INon-inhibitor0.9714
P-glycoprotein inhibitor IINon-inhibitor0.9923
Renal organic cation transporterNon-inhibitor0.921
CYP450 2C9 substrateNon-substrate0.8498
CYP450 2D6 substrateNon-substrate0.7906
CYP450 3A4 substrateNon-substrate0.7855
CYP450 1A2 substrateNon-inhibitor0.615
CYP450 2C9 inhibitorNon-inhibitor0.812
CYP450 2D6 inhibitorNon-inhibitor0.8992
CYP450 2C19 inhibitorNon-inhibitor0.8566
CYP450 3A4 inhibitorNon-inhibitor0.9008
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.8954
Ames testNon AMES toxic0.8029
CarcinogenicityCarcinogens 0.7427
BiodegradationNot ready biodegradable0.7303
Rat acute toxicity3.0004 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.9452
hERG inhibition (predictor II)Non-inhibitor0.971
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0udi-0090000000-776e7d808857b52aa594
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0udi-0090000000-776e7d808857b52aa594
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0udi-0090000000-776e7d808857b52aa594
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0udi-0090000000-9f41876d0a547fca8258
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0udi-0090000000-9f41876d0a547fca8258
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-0udi-0090000000-9f41876d0a547fca8258

Taxonomy

Description
This compound belongs to the class of inorganic compounds known as homogeneous halogens. These are inorganic non-metallic compounds in which the largest atom is a nobel gas.
Kingdom
Inorganic compounds
Super Class
Homogeneous non-metal compounds
Class
Homogeneous halogens
Sub Class
Not Available
Direct Parent
Homogeneous halogens
Alternative Parents
Not Available
Substituents
Homogeneous halogen
Molecular Framework
Not Available
External Descriptors
diatomic iodine (CHEBI:17606) / an inorganic compound (IODINE-MOLECULE)

Targets

Kind
Protein
Organism
Human
Pharmacological action
Unknown
General Function
Nadh dehydrogenase (ubiquinone) activity
Specific Function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the tra...
Gene Name
MT-ND5
Uniprot ID
P03915
Uniprot Name
NADH-ubiquinone oxidoreductase chain 5
Molecular Weight
67025.67 Da
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235]

Drug created on November 18, 2007 11:24 / Updated on November 18, 2018 04:52