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Displaying drugs 201 - 225 of 13634 in total

Bevacizumab

There is a great deal of evidence indicating that vascular endothelial growth factor (VEGF) is important for the survival and proliferation of cancer cells.[A192939,A192837,A192891,A193275] VEGF plays an important role in angiogenesis, lymphangiogenesis, and tumor growth, which are all factors that contribute to its attractiveness as a therapeutic target for anti-cancer...
Approved
Investigational
Matched Description: … tumor growth, which are all factors that contribute to its attractiveness as a therapeutic target for ... [A192834,A192888,A192837,A192891,A192894] In 2004, bevacizumab (Avastin) gained FDA approval for ... [A192888,A192939] Bevacizumab is generally indicated for use in combination with different chemotherapy …
Matched Categories: … Experimental Unapproved Treatments for COVID-19 …
Matched Products: … MVASI Concentrate for Solution for Infusion 25 mg/ml ... ZIRABEV CONCENTRATE FOR SOLUTION FOR INFUSION 100 MG/4 ML ... MVASI CONCENTRATE FOR SOLUTION FOR INFUSION 25 MG/ML …

Heparin

Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor...
Approved
Investigational
Matched Description: … and higher risk of osteoporosis in long term use. ... Unfractionated heparin is more specific than LMWH for thrombin. ... It is a naturally occurring anticoagulant released from mast cells. …
Matched Mixtures name: … Heparin Sodium in Dextrose ... Heparin Sodium in Dextrose ... Heparin Sodium in Dextrose …
Matched Categories: … Heparins or Heparinoids for Topical Use …
Matched Products: … BRAUN HEPARINISED SALINE 10IU/ML SOLUTION FOR INJECTION ... Heparin Sodium in Dextrose ... Heparin Sodium in Sodium Chloride …

Moxidectin

Moxidectin is a potent, broad-spectrum endectocide (antiparasitic that is active against endo- and ecto-parasites) with activity against nematodes, insects, and acari. It was first used in cattle followed by an approved use in general animals. It is a semi-synthetic methoxine derivative of nemadectin which is a 16-member pentacyclic lactone of...
Approved
Investigational
Vet approved
Matched Description: … [A33385] Moxidectin was developed by Medicines Development for Global Health and FDA approved in June ... It was first used in cattle followed by an approved use in general animals. ... It is a semi-synthetic methoxine derivative of nemadectin which is a 16-member pentacyclic lactone of …
Matched Mixtures name: … Advocate Spot-on Solution for Small Dogs ... Advocate Spot-on Solution for Large Dogs ... Advocate Spot-on Solution for Medium Dogs …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Vildagliptin

Vildagliptin (LAF237) is an orally active antihyperglycemic agent that selectively inhibits the dipeptidyl peptidase-4 (DPP-4) enzyme. It is used to manage type II diabetes mellitus, where GLP-1 secretion and insulinotropic effects are impaired. By inhibiting DPP-4, vildagliptin prevents the degradation of glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP),...
Approved
Investigational
Matched Description: … [L32803] Vildagliptin is also available as Eucreas, a fixed-dose formulation with metformin for adults ... Elevated levels of GLP-1 and GIP consequently results in improved glycemic control. ... [A232488] Oral vildagliptin was approved by the European Medicines Agency in 2008 for the treatment …
Matched Categories: … Drugs Used in Diabetes …

Pentoxifylline

Pentoxifylline (PTX) is a synthetic dimethylxanthine derivative that modulates the rheological properties of blood and also has both anti-oxidant and anti-inflammatory properties.[A226415, L30300] Although originally developed to treat intermittent claudication, a form of exertion-induced leg pain common in patients with peripheral arterial disease, PTX has been investigated for its possible...
Approved
Investigational
Matched Description: … leg pain common in patients with peripheral arterial disease, PTX has been investigated for its possible ... [A226410, A226415, A226455] More recently, PTX has been suggested as a possible treatment for COVID-19 ... use in diverse conditions, including osteoradionecrosis, diabetic kidney disease, and generally any …
Matched Categories: … Compounds used in a research, industrial, or household setting ... Drugs for Obstructive Airway Diseases …

Efmoroctocog alfa

Efmoroctocog alfa is a fully recombinant factor VIII-Fc fusion protein (rFVIIIFc) with an extended half-life compared with conventional factor VIII (FVIII) preparations, including recombinant FVIII (rFVIII) products such as DB13999 . It is an antihemorrhagic agent used in replacement therapy for patients with haemophilia A (congenital factor VIII deficiency). It...
Approved
Investigational
Matched Description: … It is suitable for all age groups. ... It is an antihemorrhagic agent used in replacement therapy for patients with haemophilia A (congenital ... Factor VIII is a blood coagulant factor involved in the intrinsic pathway to form fibrin, or a blood …

Febuxostat

Febuxostat is a non-purine xanthine oxidase (XO) inhibitor. In early 2008, febuxostat was granted marketing authorization by the European Commission for the treatment of chronic hyperuricemia and gout. In the following year, the FDA for approved febuxostat for use in the chronic management of hyperuricemia in adult patients with gout...
Approved
Matched Description: … [A230548] In February 2019, a black box warning for febuxostat was added, based on the findings of ... [A230548] In the following year, the FDA for approved febuxostat for use in the chronic management of ... acid, thereby reducing serum uric acid levels. …

Caffeine

Caffeine is a drug of the methylxanthine class used for a variety of purposes, including certain respiratory conditions of the premature newborn, pain relief, and to combat drowsiness. Caffeine is similar in chemical structure to Theophylline and Theobromine.[A187691,L9851] It can be sourced from coffee beans, but also occurs naturally in...
Approved
Matched Description: … Caffeine is a drug of the methylxanthine class used for a variety of purposes, including certain respiratory ... [T716] Caffeine is also used in a variety of cosmetic products and can be administered topically, orally ... [T716] The caffeine citrate injection, used for apnea of the premature newborn, was initially approved …
Matched Mixtures name: … Only For HEADACHE ... Pancold A ... Saridon - A …
Matched Categories: … Tests for Gastric Secretion ... Drugs for Obstructive Airway Diseases ... Psychostimulants, Agents Used for ADHD and Nootropics …

Budesonide

Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product...
Approved
Matched Description: … [L10598] It is also available in a combination product with [formoterol].[L10619] ... Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions …
Matched Mixtures name: … SYMBICORT RAPIHALER SUSPENSION FOR INHALATION 80/4.5 mcg/actuation ... SYMBICORT RAPIHALER SUSPENSION FOR INHALATION 160/4.5 mcg/actuation ... SYMBICORT RAPIHALER SUSPENSION FOR INHALATION 80/2.25 mcg/actuation …
Matched Categories: … Corticosteroids for Systemic Use ... Corticosteroids for inhalation use ... Drugs for Obstructive Airway Diseases …
Matched Products: … PULMICORT RESPULES (1 MG IN 2 ML) ... PULMICORT RESPULES (0.5 MG IN 2 ML) ... Frenolyn Powder for Oral Inhalation 200mcg/dose …

Paromomycin

An oligosaccharide antibiotic produced by various streptomyces. [PubChem]
Approved
Investigational
Matched Synonyms: … Monomycin A …

Imipenem

Imipenem is a semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains.[label] It is stable to many beta-lactamases. Similar compounds include meropenem, known for having greater activity against Gram negative bacteria, and the newer ertapenem which exhibits...
Approved
Matched Description: … [A15389] Imipenem is commonly used in combination with [cilastatin] and is now available in a triple-drug ... Similar compounds include [meropenem], known for having greater activity against Gram negative bacteria ... Imipenem is a semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative …
Matched Mixtures name: … IMIPENEM/CILASTATINA POLVO PARA RECONSTITUIR A SOLUCIÓN INYECTABLE ... ARZOMEBA PISA 500MG/500MG (IMIPENEM+CILASTATINA) POLVO PARA RECONSTITUIR A SOLUCIÓN INYECTABLE ... IMIPENEM /CILASTATIN KABI POWDER FOR SOLUTION FOR INFUSION 500MG/500MG …
Matched Categories: … Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …

Corifollitropin alfa

Corifollitropin alfa, also known as Elonva is used in women undergoing fertility treatment to stimulate the development of more than one mature egg (oocyte) at a time in the ovaries. This drug used together with a gonadotropin-releasing hormone (GnRH) antagonist, a type of medicine also used in fertility treatments. Elonva...
Approved
Investigational
Matched Description: … FDA for its New Drug Application for this drug. ... the development of more than one mature egg (oocyte) at a time in the ovaries. ... In July 2014, Merck announced the receipt of a Complete Response Letter (CRL) from the U.S. …
Matched Products: … Elonva Solution for Injection 150mcg/0.5ml ... Elonva Solution for Injection 100mcg/0.5ml ... Elonva (solution for injection 100mcg/0.5ml) …

Ibandronate

Ibandronate, or BM 21.0955, is a third generation, nitrogen containing bisphosphonate similar to zoledronic acid, minodronic acid, and risedronic acid.[A203111,A203138] It is used to prevent and treat postmenopausal osteoporosis.[L13805,L13808] Ibandronate was first described in the literature in 1993 as a treatment for bone loss in dogs. Ibandronate was granted FDA...
Approved
Investigational
Matched Description: … [L13805,L13808] Ibandronate was first described in the literature in 1993 as a treatment for bone loss ... in dogs. ... Ibandronate, or BM 21.0955, is a third generation, nitrogen containing bisphosphonate similar to [zoledronic …
Matched Categories: … Drugs for Treatment of Bone Diseases …
Matched Products: … OSTIVEA 3mg/3ml Solution for IV Injection in Pre-filled Syringe ... BONVIVA 3MG/3ML ILO IN FER ... BONDRONAT FOR INFUSION 1 mg/ml …

Lopinavir

Lopinavir is an antiretroviral protease inhibitor used in combination with other antiretrovirals in the treatment of HIV-1 infection. Lopinavir is marketed and administered exclusively in combination with ritonavir - this combination, first marketed by Abbott under the brand name Kaletra in 2000, is necessary due to lopinavir's poor oral bioavailability...
Approved
Matched Description: … Ritonavir is a potent inhibitor of the enzymes responsible for lopinavir metabolism, and its co-administration ... [A191757] Lopinavir was previously under investigation in combination with ritonavir for the treatment ... [saquinavir], [nelfinavir]), lopinavir is a peptidomimetic molecule - it contains a hydroxyethylene scaffold …
Matched Categories: … Antivirals used in combination for the treatment of HIV infections ... Antivirals for Systemic Use ... Antiinfectives for Systemic Use ... Experimental Unapproved Treatments for COVID-19 …

Linezolid

Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the initiation of bacterial protein synthesis - more specifically,...
Approved
Investigational
Matched Description: … Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive ... [A233425] A second member of this class, [tedizolid], was approved by the FDA in 2014 and is considered ... doing so, prevents the formation of the 70S initiation complex which is essential for bacterial reproduction …
Matched Categories: … Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates ... Antibacterials for Systemic Use ... Antiinfectives for Systemic Use …
Matched Products: … ZYVOX SOLUTION FOR INFUSION 2 mg/ml ... CINEZOLID solution for infusion 2mg/mL ... ZYVOX 20MG/ML GRANULES FOR ORAL SUSPENSION …

Melphalan

Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. It is also used for high-conditioning before hematopoietic stem...
Approved
Matched Description: … [L40928] It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group ... Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. ... [L40928] It is also used for high-conditioning before hematopoietic stem cell transplant. …
Matched Mixtures name: … Melphalan for Injection ... Melphalan for Injection …
Matched Products: … Melphalan for Injection ... ALKERAN FOR INJECTION 50 mg/vial …

Haloperidol

Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the dopamine receptor (mainly D2), particularly within...
Approved
Matched Description: … for the treatment of intractable hiccups as it is a potent antiemetic. ... [A180616] While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain ... or histaminergic receptors, resulting in a higher incidence of side effects such as sedation, weight …
Matched Products: … MYUNG IN HALOPERIDOL TABLET 1.5 mg ... MYUNG IN HALOPERIDOL INJECTION 5 mg/ml …

Iron sucrose

Iron sucrose (sucroferric oxyhydroxide or iron saccharate) is used as a source of iron in patients with iron deficiency anemia with chronic kidney disease (CKD), including those who are undergoing dialysis (hemodialysis or peritoneal) and those who do not require dialysis. Due to less side effects than iron dextran, iron...
Approved
Matched Description: … Iron sucrose (sucroferric oxyhydroxide or iron saccharate) is used as a source of iron in patients with ... Due to less side effects than iron dextran, iron sucrose is more preferred in chronic kidney disease …
Matched Categories: … Drugs for Treatment of Hyperkalemia and Hyperphosphatemia …
Matched Products: … Venofer Solution for Injection 20mg/ml ... HIERRO SACARATO EQUIVALENTE A HIERRO ELEMENTAL 100 MG/ 5ML. …

Iptacopan

Iptacopan is a small-molecule factor B inhibitor previously investigated as a potential treatment for the rare blood disease paroxysmal nocturnal hemoglobinuria (PNH) by inhibiting the complement factor B. Factor B is a positive regulator of the alternative complement pathway, where it activates C3 convertase and subsequently C5 convertase. This is...
Approved
Investigational
Matched Description: … Iptacopan is a small-molecule factor B inhibitor previously investigated as a potential treatment for ... Due to this mutation, all progeny erythrocytes will lack the glycosyl phosphatidylinositol–anchored proteins ... [A262581] On December 6th, 2023, Iptacopan under the brand name Fabhalta was approved by the FDA for …

Glutamic acid

A peptide that is a homopolymer of glutamic acid.
Approved
Nutraceutical
Matched Description: … A peptide that is a homopolymer of glutamic acid. …
Matched Mixtures name: … Aminosyn II in Dextrose ... Aminosyn II in Dextrose ... GLAMIN SOLUTION FOR INFUSION …

Thiosulfuric acid

Thiosulfuric acid is available in its salt forms sodium thiosulfate and sodium thiosulfate pentahydrate. Sodium thiosulfate is part of the World Health Organization’s list of essential medicines, and it has a variety of industrial uses, including food preservative, water de-chlorinator and paper pulp bleaching agent. Sodium thiosulfate is rapidly degraded...
Approved
Investigational
Matched Description: … ] and it is frequently used in conjunction with sodium nitrite (a salt form of [nitrous acid]). ... [A252827] Sodium thiosulfate is approved for the treatment of acute cyanide poisoning[L310,L43332,A252832 ... Thiosulfuric acid is available in its salt forms sodium thiosulfate and sodium thiosulfate pentahydrate …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Oseltamivir

Oseltamivir (marketed as the product TamifluⓇ), is an antiviral neuraminidase inhibitor used for the treatment and prophylaxis of infection with influenza viruses A (including pandemic H1N1) and B. Oseltamivir exerts its antiviral activity by inhibiting the activity of the viral neuraminidase enzyme found on the surface of the virus, which...
Approved
Matched Description: … time; there is generally no benefit in use beyond 48 hours for healthy, low-risk individuals as influenza ... They recommend the use of oseltamivir in people with a higher risk of developing complications including ... is a self-limiting illness. …
Matched Categories: … Antivirals for Systemic Use ... Antiinfectives for Systemic Use …
Matched Products: … Oseltamivir Phosphate for Oral Suspension ... FLUHALT FOR ORAL SUSPENSION 60 mg/ 5 ml ... Oseltamivir Powder for Oral Suspension …

Alfuzosin

Benign prostatic hyperplasia (BPH) refers to a benign growth or hyperplasia of the prostate and leads to lower urinary tract symptoms in men, such as urgency, frequency and changes to urine flow. The prevalence of BPH is as high as 50%-60% for males in their 60's, and this prevalence increases...
Approved
Investigational
Matched Description: … The prevalence of BPH is as high as 50%-60% for males in their 60's, and this prevalence increases to ... Benign prostatic hyperplasia (BPH) refers to a benign growth or hyperplasia of the prostate and leads ... by relaxing the muscles in the prostate and bladder neck. …
Matched Categories: … Drugs Used in Benign Prostatic Hypertrophy …

Adefovir dipivoxil

Adefovir dipivoxil, previously called bis-POM PMEA, with trade names Preveon and Hepsera, is an orally-administered acyclic nucleotide analog reverse transcriptase inhibitor (ntRTI) used for treatment of hepatitis B. It is ineffective against HIV-1. Adefovir dipivoxil is the diester prodrug of adefovir.
Approved
Investigational
Matched International brands: … A Di Xian ... A Gan Ding …
Matched Description: … Hepsera, is an orally-administered acyclic nucleotide analog reverse transcriptase inhibitor (ntRTI) used for …
Matched Categories: … Antivirals for Systemic Use ... Antiinfectives for Systemic Use …

Zidovudine

A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator...
Approved
Matched Description: … A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced ... This modification prevents the formation of phosphodiester linkages which are needed for the completion ... The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during …
Matched Mixtures name: … N/A …
Matched Categories: … Antivirals used in combination for the treatment of HIV infections ... Medications that reduce magnesium levels ... Antivirals for Systemic Use ... Antiinfectives for Systemic Use …
Matched Products: … RETROVIR IV FOR INFUSION 1% …
Displaying drugs 201 - 225 of 13634 in total