| 16-Bromoepiandrosterone | The serum concentration of 16-Bromoepiandrosterone can be increased when it is combined with Lopinavir. | Investigational |
| 19-norandrostenedione | The serum concentration of 19-norandrostenedione can be increased when it is combined with Lopinavir. | Experimental, Illicit |
| 4-Methoxyamphetamine | The metabolism of 4-Methoxyamphetamine can be decreased when combined with Lopinavir. | Experimental, Illicit |
| 5-androstenedione | The serum concentration of 5-androstenedione can be increased when it is combined with Lopinavir. | Experimental, Illicit |
| Abacavir | The serum concentration of Abacavir can be decreased when it is combined with Lopinavir. | Approved, Investigational |
| Abiraterone | The metabolism of Abiraterone can be decreased when combined with Lopinavir. | Approved |
| Acarbose | The therapeutic efficacy of Acarbose can be decreased when used in combination with Lopinavir. | Approved, Investigational |
| Acebutolol | The serum concentration of Acebutolol can be increased when it is combined with Lopinavir. | Approved |
| Acenocoumarol | The metabolism of Acenocoumarol can be decreased when combined with Lopinavir. | Approved |
| Acetaminophen | The metabolism of Acetaminophen can be decreased when combined with Lopinavir. | Approved |
| Acetohexamide | The therapeutic efficacy of Acetohexamide can be decreased when used in combination with Lopinavir. | Withdrawn |
| Acetylcholine | The metabolism of Acetylcholine can be decreased when combined with Lopinavir. | Approved |
| Acetylsalicylic acid | The metabolism of Acetylsalicylic acid can be decreased when combined with Lopinavir. | Approved, Vet Approved |
| Adinazolam | The metabolism of Adinazolam can be decreased when combined with Lopinavir. | Approved |
| Afatinib | The serum concentration of Afatinib can be increased when it is combined with Lopinavir. | Approved |
| AICA ribonucleotide | The therapeutic efficacy of Aicar can be decreased when used in combination with Lopinavir. | Experimental |
| Ajmaline | The metabolism of Ajmaline can be decreased when combined with Lopinavir. | Approved |
| Albendazole | The metabolism of Albendazole can be decreased when combined with Lopinavir. | Approved, Vet Approved |
| Alclometasone | The metabolism of Alclometasone can be decreased when combined with Lopinavir. | Approved |
| Aldosterone | The serum concentration of Aldosterone can be increased when it is combined with Lopinavir. | Experimental |
| Alfentanil | The metabolism of Alfentanil can be decreased when combined with Lopinavir. | Approved, Illicit |
| Alfuzosin | The serum concentration of Alfuzosin can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Aliskiren | The metabolism of Aliskiren can be decreased when combined with Lopinavir. | Approved, Investigational |
| Alitretinoin | The serum concentration of Alitretinoin can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Allylestrenol | The metabolism of Allylestrenol can be decreased when combined with Lopinavir. | Approved |
| Almotriptan | The serum concentration of Almotriptan can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Alogliptin | The metabolism of Alogliptin can be decreased when combined with Lopinavir. | Approved |
| Alosetron | The serum concentration of Alosetron can be increased when it is combined with Lopinavir. | Approved, Withdrawn |
| Alprazolam | The serum concentration of Alprazolam can be increased when it is combined with Lopinavir. | Approved, Illicit, Investigational |
| Alprenolol | The metabolism of Alprenolol can be decreased when combined with Lopinavir. | Approved, Withdrawn |
| Amantadine | Amantadine may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Ambrisentan | The metabolism of Ambrisentan can be decreased when combined with Lopinavir. | Approved, Investigational |
| Ambroxol | The metabolism of Ambroxol can be decreased when combined with Lopinavir. | Approved |
| Ambroxol acefyllinate | The serum concentration of Ambroxol acefyllinate can be decreased when it is combined with Lopinavir. | Experimental |
| Amcinonide | The serum concentration of Amcinonide can be increased when it is combined with Lopinavir. | Approved |
| Amineptine | The serum concentration of Amineptine can be increased when it is combined with Lopinavir. | Illicit, Withdrawn |
| Aminophenazone | The metabolism of Aminophenazone can be decreased when combined with Lopinavir. | Approved, Withdrawn |
| Aminophylline | The metabolism of Aminophylline can be decreased when combined with Lopinavir. | Approved |
| Amiodarone | Lopinavir may increase the QTc-prolonging activities of Amiodarone. | Approved, Investigational |
| Amitriptyline | The metabolism of Amitriptyline can be decreased when combined with Lopinavir. | Approved |
| Amlodipine | The metabolism of Amlodipine can be decreased when combined with Lopinavir. | Approved |
| Amodiaquine | The metabolism of Amodiaquine can be decreased when combined with Lopinavir. | Approved |
| Amoxapine | Amoxapine may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Amoxicillin | The metabolism of Amoxicillin can be increased when combined with Lopinavir. | Approved, Vet Approved |
| Amphetamine | The metabolism of Amphetamine can be decreased when combined with Lopinavir. | Approved, Illicit |
| Amprenavir | The metabolism of Amprenavir can be decreased when combined with Lopinavir. | Approved |
| Amsacrine | The metabolism of Amsacrine can be decreased when combined with Lopinavir. | Approved |
| Anagrelide | Anagrelide may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Androstenedione | The serum concentration of 4-Androstenedione can be increased when it is combined with Lopinavir. | Experimental, Illicit |
| Antipyrine | The metabolism of Antipyrine can be decreased when combined with Lopinavir. | Approved |
| Apixaban | The serum concentration of Apixaban can be increased when it is combined with Lopinavir. | Approved |
| Apomorphine | Apomorphine may increase the QTc-prolonging activities of Lopinavir. | Approved, Investigational |
| Apremilast | The metabolism of Apremilast can be decreased when combined with Lopinavir. | Approved, Investigational |
| Aprepitant | The serum concentration of Lopinavir can be increased when it is combined with Aprepitant. | Approved, Investigational |
| Aprindine | The metabolism of Aprindine can be decreased when combined with Lopinavir. | Approved |
| Arformoterol | Arformoterol may increase the QTc-prolonging activities of Lopinavir. | Approved, Investigational |
| Argatroban | The metabolism of Argatroban can be decreased when combined with Lopinavir. | Approved, Investigational |
| Aripiprazole | The serum concentration of Aripiprazole can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Arsenic trioxide | Arsenic trioxide may increase the QTc-prolonging activities of Lopinavir. | Approved, Investigational |
| Artemether | Lopinavir may increase the QTc-prolonging activities of Artemether. | Approved |
| Asenapine | Lopinavir may increase the QTc-prolonging activities of Asenapine. | Approved |
| Astemizole | The serum concentration of Astemizole can be increased when it is combined with Lopinavir. | Approved, Withdrawn |
| Atazanavir | The metabolism of Lopinavir can be decreased when combined with Atazanavir. | Approved, Investigational |
| Atenolol | The serum concentration of Atenolol can be increased when it is combined with Lopinavir. | Approved |
| Atomoxetine | The serum concentration of Atomoxetine can be increased when it is combined with Lopinavir. | Approved |
| Atorvastatin | The serum concentration of Atorvastatin can be increased when it is combined with Lopinavir. | Approved |
| Avanafil | The serum concentration of Avanafil can be increased when it is combined with Lopinavir. | Approved |
| Axitinib | The serum concentration of Axitinib can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Azelastine | The metabolism of Azelastine can be decreased when combined with Lopinavir. | Approved |
| Azithromycin | Azithromycin may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Banoxantrone | The metabolism of Banoxantrone can be decreased when combined with Lopinavir. | Investigational |
| Barnidipine | The serum concentration of Barnidipine can be increased when it is combined with Lopinavir. | Approved |
| Beclomethasone dipropionate | The serum concentration of Beclomethasone dipropionate can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Bedaquiline | The serum concentration of Bedaquiline can be increased when it is combined with Lopinavir. | Approved |
| Benzatropine | The metabolism of Benzatropine can be decreased when combined with Lopinavir. | Approved |
| Benzphetamine | The metabolism of Benzphetamine can be decreased when combined with Lopinavir. | Approved, Illicit |
| Benzyl alcohol | The metabolism of Benzyl alcohol can be decreased when combined with Lopinavir. | Approved |
| Bepridil | The metabolism of Bepridil can be decreased when combined with Lopinavir. | Approved, Withdrawn |
| Beraprost | The metabolism of Beraprost can be decreased when combined with Lopinavir. | Investigational |
| Betamethasone | The serum concentration of Betamethasone can be increased when it is combined with Lopinavir. | Approved, Vet Approved |
| Betaxolol | The metabolism of Betaxolol can be decreased when combined with Lopinavir. | Approved |
| Bexarotene | The metabolism of Bexarotene can be decreased when combined with Lopinavir. | Approved, Investigational |
| Bezafibrate | The metabolism of Bezafibrate can be decreased when combined with Lopinavir. | Approved |
| Bicalutamide | The metabolism of Bicalutamide can be decreased when combined with Lopinavir. | Approved |
| Bisoprolol | The metabolism of Bisoprolol can be decreased when combined with Lopinavir. | Approved |
| Boceprevir | The serum concentration of Lopinavir can be decreased when it is combined with Boceprevir. | Approved, Investigational |
| Bortezomib | The serum concentration of Bortezomib can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Bosentan | The serum concentration of Bosentan can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Bosutinib | The serum concentration of Bosutinib can be increased when it is combined with Lopinavir. | Approved |
| Brentuximab vedotin | The serum concentration of Brentuximab vedotin can be increased when it is combined with Lopinavir. | Approved |
| Brexpiprazole | The serum concentration of Brexpiprazole can be increased when it is combined with Lopinavir. | Approved |
| Brinzolamide | The serum concentration of Brinzolamide can be increased when it is combined with Lopinavir. | Approved |
| Bromazepam | The metabolism of Bromazepam can be decreased when combined with Lopinavir. | Approved, Illicit |
| Bromocriptine | The serum concentration of Bromocriptine can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Brompheniramine | The metabolism of Brompheniramine can be decreased when combined with Lopinavir. | Approved |
| Budesonide | The serum concentration of Budesonide can be increased when it is combined with Lopinavir. | Approved |
| Budesonide | The metabolism of Budesonide can be decreased when combined with Lopinavir. | Approved |
| Buformin | The therapeutic efficacy of Buformin can be decreased when used in combination with Lopinavir. | Withdrawn |
| Bufuralol | The metabolism of Bufuralol can be decreased when combined with Lopinavir. | Experimental, Investigational |
| Bupivacaine | The metabolism of Bupivacaine can be decreased when combined with Lopinavir. | Approved, Investigational |
| Buprenorphine | The metabolism of Buprenorphine can be decreased when combined with Lopinavir. | Approved, Illicit, Investigational, Vet Approved |
| Bupropion | The serum concentration of Bupropion can be decreased when it is combined with Lopinavir. | Approved |
| Buserelin | Buserelin may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Buspirone | The metabolism of Buspirone can be decreased when combined with Lopinavir. | Approved, Investigational |
| Busulfan | The metabolism of Busulfan can be decreased when combined with Lopinavir. | Approved, Investigational |
| Cabazitaxel | The serum concentration of Cabazitaxel can be increased when it is combined with Lopinavir. | Approved |
| Cabergoline | The serum concentration of Cabergoline can be increased when it is combined with Lopinavir. | Approved |
| Cabozantinib | The serum concentration of Cabozantinib can be increased when it is combined with Lopinavir. | Approved |
| Caffeine | The metabolism of Caffeine can be decreased when combined with Lopinavir. | Approved |
| Calcitriol | The metabolism of Calcitriol can be decreased when combined with Lopinavir. | Approved, Nutraceutical |
| Camptothecin | The serum concentration of Camptothecin can be increased when it is combined with Lopinavir. | Experimental |
| Canagliflozin | The metabolism of Canagliflozin can be decreased when combined with Lopinavir. | Approved |
| Captopril | The metabolism of Captopril can be decreased when combined with Lopinavir. | Approved |
| Carbamazepine | The serum concentration of Lopinavir can be decreased when it is combined with Carbamazepine. | Approved, Investigational |
| Carbinoxamine | The metabolism of Carbinoxamine can be decreased when combined with Lopinavir. | Approved |
| Carfilzomib | The serum concentration of Carfilzomib can be increased when it is combined with Lopinavir. | Approved |
| Cariprazine | The metabolism of Cariprazine can be decreased when combined with Lopinavir. | Approved |
| Carisoprodol | The metabolism of Carisoprodol can be increased when combined with Lopinavir. | Approved |
| Carteolol | The metabolism of Carteolol can be decreased when combined with Lopinavir. | Approved |
| Carvedilol | The metabolism of Carvedilol can be decreased when combined with Lopinavir. | Approved, Investigational |
| Castanospermine | The therapeutic efficacy of Castanospermine can be decreased when used in combination with Lopinavir. | Experimental |
| Celecoxib | The metabolism of Celecoxib can be decreased when combined with Lopinavir. | Approved, Investigational |
| Celiprolol | The metabolism of Celiprolol can be decreased when combined with Lopinavir. | Approved, Investigational |
| Cephalexin | The metabolism of Cephalexin can be decreased when combined with Lopinavir. | Approved, Vet Approved |
| Ceritinib | The serum concentration of Ceritinib can be increased when it is combined with Lopinavir. | Approved |
| Cerivastatin | The metabolism of Cerivastatin can be decreased when combined with Lopinavir. | Withdrawn |
| Cevimeline | The metabolism of Cevimeline can be decreased when combined with Lopinavir. | Approved |
| Chenodeoxycholic acid | The metabolism of Chenodeoxycholic acid can be decreased when combined with Lopinavir. | Approved |
| Chloramphenicol | The metabolism of Chloramphenicol can be increased when combined with Lopinavir. | Approved, Vet Approved |
| Chlordiazepoxide | The metabolism of Chlordiazepoxide can be decreased when combined with Lopinavir. | Approved, Illicit |
| Chloroquine | Chloroquine may increase the QTc-prolonging activities of Lopinavir. | Approved, Vet Approved |
| Chlorotrianisene | The serum concentration of Chlorotrianisene can be decreased when it is combined with Lopinavir. | Withdrawn |
| Chlorphenamine | The metabolism of Chlorphenamine can be decreased when combined with Lopinavir. | Approved |
| Chlorpromazine | Chlorpromazine may increase the QTc-prolonging activities of Lopinavir. | Approved, Vet Approved |
| Chlorpropamide | The metabolism of Chlorpropamide can be increased when combined with Lopinavir. | Approved |
| Chlorzoxazone | The metabolism of Chlorzoxazone can be decreased when combined with Lopinavir. | Approved |
| Cholecalciferol | The metabolism of Cholecalciferol can be decreased when combined with Lopinavir. | Approved, Nutraceutical |
| Ciclesonide | The metabolism of Ciclesonide can be decreased when combined with Lopinavir. | Approved, Investigational |
| Ciglitazone | The therapeutic efficacy of Ciglitazone can be decreased when used in combination with Lopinavir. | Experimental |
| Cilostazol | The serum concentration of Cilostazol can be increased when it is combined with Lopinavir. | Approved |
| Cimetidine | The serum concentration of Cimetidine can be increased when it is combined with Lopinavir. | Approved |
| Cinacalcet | The metabolism of Cinacalcet can be decreased when combined with Lopinavir. | Approved |
| Cinnarizine | The metabolism of Cinnarizine can be decreased when combined with Lopinavir. | Approved |
| Ciprofloxacin | Ciprofloxacin may increase the QTc-prolonging activities of Lopinavir. | Approved, Investigational |
| Cisapride | The serum concentration of Cisapride can be increased when it is combined with Lopinavir. | Approved, Investigational, Withdrawn |
| Cisplatin | The serum concentration of Cisplatin can be increased when it is combined with Lopinavir. | Approved |
| Citalopram | Citalopram may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Clarithromycin | Clarithromycin may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Clemastine | The metabolism of Lopinavir can be decreased when combined with Clemastine. | Approved |
| Clevidipine | The metabolism of Clevidipine can be decreased when combined with Lopinavir. | Approved |
| Clindamycin | The metabolism of Clindamycin can be decreased when combined with Lopinavir. | Approved, Vet Approved |
| Clobazam | The metabolism of Clobazam can be decreased when combined with Lopinavir. | Approved, Illicit |
| Clobetasol propionate | The serum concentration of Clobetasol propionate can be increased when it is combined with Lopinavir. | Approved |
| Clocortolone | The serum concentration of Clocortolone can be increased when it is combined with Lopinavir. | Approved |
| Clofazimine | The metabolism of Clofazimine can be decreased when combined with Lopinavir. | Approved, Investigational |
| Clofibrate | The metabolism of Clofibrate can be decreased when combined with Lopinavir. | Approved |
| Clomifene | The serum concentration of Clomifene can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Clomipramine | The metabolism of Clomipramine can be decreased when combined with Lopinavir. | Approved, Vet Approved |
| Clonazepam | The metabolism of Clonazepam can be decreased when combined with Lopinavir. | Approved, Illicit |
| Clonidine | The metabolism of Clonidine can be decreased when combined with Lopinavir. | Approved |
| Clopidogrel | The metabolism of Clopidogrel can be decreased when combined with Lopinavir. | Approved, Nutraceutical |
| Clorazepate | The metabolism of Clorazepate can be decreased when combined with Lopinavir. | Approved, Illicit |
| Clotiazepam | The metabolism of Clotiazepam can be decreased when combined with Lopinavir. | Approved, Illicit |
| Clotrimazole | The metabolism of Lopinavir can be decreased when combined with Clotrimazole. | Approved, Vet Approved |
| Clozapine | Clozapine may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Cobicistat | The metabolism of Lopinavir can be decreased when combined with Cobicistat. | Approved |
| Cobimetinib | The serum concentration of Cobimetinib can be increased when it is combined with Lopinavir. | Approved |
| Cocaine | The metabolism of Cocaine can be decreased when combined with Lopinavir. | Approved, Illicit |
| Codeine | The therapeutic efficacy of Codeine can be decreased when used in combination with Lopinavir. | Approved, Illicit |
| Colchicine | The serum concentration of Colchicine can be increased when it is combined with Lopinavir. | Approved |
| Conivaptan | The serum concentration of Conivaptan can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Conjugated estrogens | The metabolism of Conjugated Equine Estrogens can be decreased when combined with Lopinavir. | Approved |
| Cortisone acetate | The metabolism of Cortisone acetate can be decreased when combined with Lopinavir. | Approved |
| Crizotinib | The serum concentration of Crizotinib can be increased when it is combined with Lopinavir. | Approved |
| Cyclobenzaprine | The metabolism of Cyclobenzaprine can be decreased when combined with Lopinavir. | Approved |
| Cyclophosphamide | The risk or severity of adverse effects can be increased when Lopinavir is combined with Cyclophosphamide. | Approved, Investigational |
| Cyclosporine | The serum concentration of Cyclosporine can be increased when it is combined with Lopinavir. | Approved, Investigational, Vet Approved |
| Cyclosporine | The metabolism of Cyclosporine can be decreased when combined with Lopinavir. | Approved, Investigational, Vet Approved |
| Cytarabine | The metabolism of Cytarabine can be decreased when combined with Lopinavir. | Approved, Investigational |
| Dabigatran etexilate | The serum concentration of the active metabolites of Dabigatran etexilate can be increased when Dabigatran etexilate is used in combination with Lopinavir. | Approved |
| Dabrafenib | The serum concentration of Lopinavir can be decreased when it is combined with Dabrafenib. | Approved |
| Daclatasvir | The serum concentration of Daclatasvir can be increased when it is combined with Lopinavir. | Approved |
| Dactinomycin | The serum concentration of Dactinomycin can be increased when it is combined with Lopinavir. | Approved |
| Dantrolene | The metabolism of Dantrolene can be decreased when combined with Lopinavir. | Approved |
| Dapagliflozin | The metabolism of Dapagliflozin can be decreased when combined with Lopinavir. | Approved |
| Dapoxetine | The serum concentration of Dapoxetine can be increased when it is combined with Lopinavir. | Investigational |
| Dapsone | The metabolism of Dapsone can be decreased when combined with Lopinavir. | Approved, Investigational |
| Darifenacin | The metabolism of Darifenacin can be decreased when combined with Lopinavir. | Approved, Investigational |
| Darunavir | The serum concentration of Darunavir can be decreased when it is combined with Lopinavir. | Approved |
| Dasabuvir | The serum concentration of Dasabuvir can be increased when it is combined with Lopinavir. | Approved |
| Dasatinib | The serum concentration of Dasatinib can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Daunorubicin | The metabolism of Daunorubicin can be decreased when combined with Lopinavir. | Approved |
| Debrisoquin | The metabolism of Debrisoquin can be decreased when combined with Lopinavir. | Approved |
| Deferasirox | The serum concentration of Lopinavir can be decreased when it is combined with Deferasirox. | Approved, Investigational |
| Degarelix | Degarelix may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Delavirdine | The serum concentration of Delavirdine can be decreased when it is combined with Lopinavir. | Approved |
| Desflurane | Desflurane may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Desipramine | Desipramine may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Desogestrel | The serum concentration of Desogestrel can be decreased when it is combined with Lopinavir. | Approved |
| Desoximetasone | The serum concentration of Desoximetasone can be increased when it is combined with Lopinavir. | Approved |
| Desoxycorticosterone Pivalate | The serum concentration of Desoxycorticosterone Pivalate can be increased when it is combined with Lopinavir. | Experimental, Vet Approved |
| Desvenlafaxine | The metabolism of Desvenlafaxine can be decreased when combined with Lopinavir. | Approved |
| Dexamethasone | The metabolism of Dexamethasone can be decreased when combined with Lopinavir. | Approved, Investigational, Vet Approved |
| Dexfenfluramine | The metabolism of Dexfenfluramine can be decreased when combined with Lopinavir. | Approved, Illicit, Withdrawn |
| Dexmethylphenidate | The metabolism of Dexmethylphenidate can be decreased when combined with Lopinavir. | Approved |
| Dextroamphetamine | The metabolism of Dextroamphetamine can be decreased when combined with Lopinavir. | Approved, Illicit |
| Dextromethorphan | The metabolism of Dextromethorphan can be decreased when combined with Lopinavir. | Approved |
| Dextropropoxyphene | The metabolism of Dextropropoxyphene can be decreased when combined with Lopinavir. | Approved, Illicit, Withdrawn |
| Diazepam | The metabolism of Diazepam can be decreased when combined with Lopinavir. | Approved, Illicit, Vet Approved |
| Diclofenac | The metabolism of Diclofenac can be decreased when combined with Lopinavir. | Approved, Vet Approved |
| Didanosine | The serum concentration of Didanosine can be decreased when it is combined with Lopinavir. | Approved |
| Dienestrol | The serum concentration of Dienestrol can be decreased when it is combined with Lopinavir. | Approved |
| Dienogest | The serum concentration of Dienogest can be decreased when it is combined with Lopinavir. | Approved |
| Diethylstilbestrol | The serum concentration of Diethylstilbestrol can be decreased when it is combined with Lopinavir. | Approved |
| Diflorasone | The serum concentration of Diflorasone can be increased when it is combined with Lopinavir. | Approved |
| Difluocortolone | The serum concentration of Difluocortolone can be increased when it is combined with Lopinavir. | Approved |
| Difluprednate | The serum concentration of Difluprednate can be increased when it is combined with Lopinavir. | Approved |
| Digitoxin | The metabolism of Digitoxin can be decreased when combined with Lopinavir. | Approved |
| Digoxin | The serum concentration of Digoxin can be increased when it is combined with Lopinavir. | Approved |
| Dihydrocodeine | The metabolism of Dihydrocodeine can be decreased when combined with Lopinavir. | Approved, Illicit |
| Dihydroergotamine | The serum concentration of Dihydroergotamine can be increased when it is combined with Lopinavir. | Approved |
| Dihydrotestosterone | The serum concentration of Dihydrotestosterone can be increased when it is combined with Lopinavir. | Illicit |
| Diltiazem | The metabolism of Diltiazem can be decreased when combined with Lopinavir. | Approved |
| Diphenhydramine | Diphenhydramine may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Dipyridamole | The serum concentration of Dipyridamole can be increased when it is combined with Lopinavir. | Approved |
| Disopyramide | Disopyramide may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Disulfiram | The risk or severity of adverse effects can be increased when Lopinavir is combined with Disulfiram. | Approved |
| Docetaxel | The metabolism of Docetaxel can be decreased when combined with Lopinavir. | Approved, Investigational |
| Dofetilide | The serum concentration of Dofetilide can be increased when it is combined with Lopinavir. | Approved |
| Dolasetron | Dolasetron may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Domperidone | The serum concentration of Domperidone can be increased when it is combined with Lopinavir. | Approved, Investigational, Vet Approved |
| Donepezil | The metabolism of Donepezil can be decreased when combined with Lopinavir. | Approved |
| Dopamine | The metabolism of Dopamine can be decreased when combined with Lopinavir. | Approved |
| Dorzolamide | The metabolism of Dorzolamide can be decreased when combined with Lopinavir. | Approved |
| Dosulepin | The serum concentration of Dosulepin can be increased when it is combined with Lopinavir. | Approved |
| Doxazosin | The metabolism of Doxazosin can be decreased when combined with Lopinavir. | Approved |
| Doxepin | The metabolism of Doxepin can be decreased when combined with Lopinavir. | Approved |
| Doxorubicin | The serum concentration of Doxorubicin can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Doxorubicin | The metabolism of Doxorubicin can be decreased when combined with Lopinavir. | Approved, Investigational |
| Doxycycline | The metabolism of Lopinavir can be decreased when combined with Doxycycline. | Approved, Investigational, Vet Approved |
| Dronabinol | The serum concentration of Dronabinol can be increased when it is combined with Lopinavir. | Approved, Illicit |
| Dronedarone | The serum concentration of Dronedarone can be increased when it is combined with Lopinavir. | Approved |
| Droperidol | Droperidol may increase the QTc-prolonging activities of Lopinavir. | Approved, Vet Approved |
| Drospirenone | The serum concentration of Drospirenone can be decreased when it is combined with Lopinavir. | Approved |
| Dulaglutide | The therapeutic efficacy of Dulaglutide can be decreased when used in combination with Lopinavir. | Approved |
| Duloxetine | The serum concentration of Duloxetine can be increased when it is combined with Lopinavir. | Approved |
| Dutasteride | The serum concentration of Dutasteride can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Dyphylline | The serum concentration of Dyphylline can be decreased when it is combined with Lopinavir. | Approved |
| Edoxaban | The serum concentration of Edoxaban can be increased when it is combined with Lopinavir. | Approved |
| Efavirenz | The serum concentration of Lopinavir can be decreased when it is combined with Efavirenz. | Approved, Investigational |
| Eletriptan | The serum concentration of Eletriptan can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Eliglustat | The serum concentration of Eliglustat can be increased when it is combined with Lopinavir. | Approved |
| Eltrombopag | The metabolism of Eltrombopag can be decreased when combined with Lopinavir. | Approved |
| Eluxadoline | The serum concentration of Eluxadoline can be increased when it is combined with Lopinavir. | Approved |
| Elvitegravir | The serum concentration of Elvitegravir can be increased when it is combined with Lopinavir. | Approved |
| Empagliflozin | The therapeutic efficacy of Empagliflozin can be decreased when used in combination with Lopinavir. | Approved |
| Enalapril | The metabolism of Enalapril can be decreased when combined with Lopinavir. | Approved, Vet Approved |
| Encainide | The metabolism of Encainide can be decreased when combined with Lopinavir. | Approved, Withdrawn |
| Enclomiphene | The metabolism of Enclomiphene can be decreased when combined with Lopinavir. | Investigational |
| Enfuvirtide | The serum concentration of Enfuvirtide can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Enzalutamide | The serum concentration of Enzalutamide can be increased when it is combined with Lopinavir. | Approved |
| Epinastine | The metabolism of Epinastine can be decreased when combined with Lopinavir. | Approved, Investigational |
| Eplerenone | The serum concentration of Eplerenone can be increased when it is combined with Lopinavir. | Approved |
| Equilenin | The serum concentration of Equilenin can be increased when it is combined with Lopinavir. | Experimental |
| Equilin | The serum concentration of Equilin can be increased when it is combined with Lopinavir. | Approved |
| Ergocalciferol | The metabolism of Ergocalciferol can be decreased when combined with Lopinavir. | Approved, Nutraceutical |
| Ergoloid mesylate | The serum concentration of Ergoloid mesylate can be increased when it is combined with Lopinavir. | Approved |
| Ergonovine | The serum concentration of Ergonovine can be increased when it is combined with Lopinavir. | Approved |
| Ergotamine | The serum concentration of Ergotamine can be increased when it is combined with Lopinavir. | Approved |
| Eribulin | Eribulin may increase the QTc-prolonging activities of Lopinavir. | Approved, Investigational |
| Erlotinib | The serum concentration of Erlotinib can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Erythromycin | Erythromycin may increase the QTc-prolonging activities of Lopinavir. | Approved, Vet Approved |
| Escitalopram | Escitalopram may increase the QTc-prolonging activities of Lopinavir. | Approved, Investigational |
| Eslicarbazepine acetate | The serum concentration of Lopinavir can be decreased when it is combined with Eslicarbazepine acetate. | Approved |
| Esmirtazapine | The metabolism of Esmirtazapine can be decreased when combined with Lopinavir. | Investigational |
| Esomeprazole | The metabolism of Esomeprazole can be decreased when combined with Lopinavir. | Approved, Investigational |
| Estazolam | The serum concentration of Estazolam can be increased when it is combined with Lopinavir. | Approved, Illicit |
| Estradiol | The metabolism of Estradiol can be decreased when combined with Lopinavir. | Approved, Investigational, Vet Approved |
| Estramustine | The metabolism of Estramustine can be decreased when combined with Lopinavir. | Approved |
| Estriol | The serum concentration of Estriol can be increased when it is combined with Lopinavir. | Approved, Vet Approved |
| Estrogens, esterified | The serum concentration of Estrogens, esterified can be decreased when it is combined with Lopinavir. | Approved |
| Estrone | The metabolism of Estrone can be decreased when combined with Lopinavir. | Approved |
| Estrone sulfate | The metabolism of Estrone sulfate can be decreased when combined with Lopinavir. | Approved |
| Eszopiclone | The metabolism of Eszopiclone can be decreased when combined with Lopinavir. | Approved |
| Ethanol | The metabolism of Ethanol can be decreased when combined with Lopinavir. | Approved |
| Ethinyl Estradiol | The metabolism of Ethinyl Estradiol can be decreased when combined with Lopinavir. | Approved |
| Ethosuximide | The metabolism of Ethosuximide can be decreased when combined with Lopinavir. | Approved |
| Ethylmorphine | The metabolism of Ethylmorphine can be decreased when combined with Lopinavir. | Approved, Illicit |
| Ethynodiol diacetate | The serum concentration of Ethynodiol diacetate can be decreased when it is combined with Lopinavir. | Approved |
| Etizolam | The serum concentration of Etizolam can be increased when it is combined with Lopinavir. | Approved |
| Etonogestrel | The serum concentration of Etonogestrel can be decreased when it is combined with Lopinavir. | Approved, Investigational |
| Etoposide | The metabolism of Etoposide can be decreased when combined with Lopinavir. | Approved |
| Etoricoxib | The metabolism of Etoricoxib can be decreased when combined with Lopinavir. | Approved, Investigational |
| Etravirine | The serum concentration of Etravirine can be decreased when it is combined with Lopinavir. | Approved |
| Everolimus | The serum concentration of Everolimus can be increased when it is combined with Lopinavir. | Approved |
| Exemestane | The metabolism of Exemestane can be decreased when combined with Lopinavir. | Approved, Investigational |
| Exenatide | The therapeutic efficacy of Exenatide can be decreased when used in combination with Lopinavir. | Approved, Investigational |
| Ezetimibe | The serum concentration of Ezetimibe can be increased when it is combined with Lopinavir. | Approved |
| Ezogabine | Ezogabine may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Famciclovir | The metabolism of Famciclovir can be decreased when combined with Lopinavir. | Approved |
| Famotidine | Famotidine may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Felbamate | The metabolism of Felbamate can be decreased when combined with Lopinavir. | Approved |
| Felodipine | The metabolism of Felodipine can be decreased when combined with Lopinavir. | Approved, Investigational |
| Fenofibrate | The metabolism of Fenofibrate can be decreased when combined with Lopinavir. | Approved |
| Fentanyl | The serum concentration of Fentanyl can be increased when it is combined with Lopinavir. | Approved, Illicit, Investigational, Vet Approved |
| Fesoterodine | The serum concentration of the active metabolites of Fesoterodine can be increased when Fesoterodine is used in combination with Lopinavir. | Approved |
| Fexofenadine | The serum concentration of Fexofenadine can be increased when it is combined with Lopinavir. | Approved |
| Fidaxomicin | The serum concentration of Fidaxomicin can be increased when it is combined with Lopinavir. | Approved |
| Finasteride | The metabolism of Finasteride can be decreased when combined with Lopinavir. | Approved |
| Fingolimod | The metabolism of Fingolimod can be decreased when combined with Lopinavir. | Approved, Investigational |
| Flecainide | Flecainide may increase the QTc-prolonging activities of Lopinavir. | Approved, Withdrawn |
| Flibanserin | The serum concentration of Flibanserin can be increased when it is combined with Lopinavir. | Approved |
| Fluconazole | Fluconazole may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Fludrocortisone | The serum concentration of Fludrocortisone can be increased when it is combined with Lopinavir. | Approved |
| Flumethasone | The serum concentration of Flumethasone can be increased when it is combined with Lopinavir. | Approved, Vet Approved |
| Flunarizine | The metabolism of Flunarizine can be decreased when combined with Lopinavir. | Approved |
| Flunisolide | The metabolism of Flunisolide can be decreased when combined with Lopinavir. | Approved, Investigational |
| Flunitrazepam | The metabolism of Flunitrazepam can be decreased when combined with Lopinavir. | Approved, Illicit |
| Fluocinolone Acetonide | The serum concentration of Fluocinolone Acetonide can be increased when it is combined with Lopinavir. | Approved, Investigational, Vet Approved |
| Fluocinonide | The serum concentration of Fluocinonide can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Fluocortolone | The serum concentration of Fluocortolone can be increased when it is combined with Lopinavir. | Approved, Withdrawn |
| Fluorometholone | The metabolism of Fluorometholone can be decreased when combined with Lopinavir. | Approved |
| Fluorouracil | The metabolism of Fluorouracil can be decreased when combined with Lopinavir. | Approved |
| Fluoxetine | Fluoxetine may increase the QTc-prolonging activities of Lopinavir. | Approved, Vet Approved |
| Flupentixol | Flupentixol may increase the QTc-prolonging activities of Lopinavir. | Approved, Withdrawn |
| Fluphenazine | The metabolism of Fluphenazine can be decreased when combined with Lopinavir. | Approved |
| Fluprednidene | The serum concentration of Fluprednidene can be increased when it is combined with Lopinavir. | Approved, Withdrawn |
| Flurandrenolide | The serum concentration of Flurandrenolide can be increased when it is combined with Lopinavir. | Approved |
| Flurazepam | The metabolism of Flurazepam can be decreased when combined with Lopinavir. | Approved, Illicit |
| Flutamide | The metabolism of Flutamide can be decreased when combined with Lopinavir. | Approved |
| Fluticasone furoate | The metabolism of Fluticasone furoate can be decreased when combined with Lopinavir. | Approved |
| Fluticasone Propionate | The serum concentration of Fluticasone Propionate can be increased when it is combined with Lopinavir. | Approved |
| Fluticasone Propionate | The metabolism of Fluticasone Propionate can be decreased when combined with Lopinavir. | Approved |
| Fluvastatin | The metabolism of Fluvastatin can be decreased when combined with Lopinavir. | Approved |
| Fluvoxamine | The metabolism of Fluvoxamine can be decreased when combined with Lopinavir. | Approved, Investigational |
| Formestane | The serum concentration of Formestane can be increased when it is combined with Lopinavir. | Approved, Investigational, Withdrawn |
| Formoterol | Formoterol may increase the QTc-prolonging activities of Lopinavir. | Approved, Investigational |
| Fosamprenavir | The serum concentration of Lopinavir can be decreased when it is combined with Fosamprenavir. | Approved |
| Fosaprepitant | The serum concentration of Lopinavir can be increased when it is combined with Fosaprepitant. | Approved |
| Foscarnet | Foscarnet may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Fosphenytoin | The serum concentration of Lopinavir can be decreased when it is combined with Fosphenytoin. | Approved |
| Fulvestrant | The metabolism of Fulvestrant can be decreased when combined with Lopinavir. | Approved, Investigational |
| Fusidic Acid | The serum concentration of Lopinavir can be increased when it is combined with Fusidic Acid. | Approved |
| Gadobenic acid | Gadobenic acid may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Galantamine | The metabolism of Galantamine can be decreased when combined with Lopinavir. | Approved |
| Gefitinib | The metabolism of Gefitinib can be decreased when combined with Lopinavir. | Approved, Investigational |
| Gemcitabine | The serum concentration of Gemcitabine can be increased when it is combined with Lopinavir. | Approved |
| Gemfibrozil | The metabolism of Gemfibrozil can be decreased when combined with Lopinavir. | Approved |
| Gemifloxacin | Gemifloxacin may increase the QTc-prolonging activities of Lopinavir. | Approved, Investigational |
| Gestodene | The serum concentration of Gestodene can be decreased when it is combined with Lopinavir. | Approved |
| Glibornuride | The therapeutic efficacy of Glibornuride can be decreased when used in combination with Lopinavir. | Withdrawn |
| Gliclazide | The metabolism of Gliclazide can be increased when combined with Lopinavir. | Approved |
| Glimepiride | The therapeutic efficacy of Glimepiride can be decreased when used in combination with Lopinavir. | Approved |
| Glipizide | The metabolism of Glipizide can be decreased when combined with Lopinavir. | Approved |
| Gliquidone | The therapeutic efficacy of Gliquidone can be decreased when used in combination with Lopinavir. | Approved |
| Glucosamine | The metabolism of Glucosamine can be increased when combined with Lopinavir. | Approved |
| Glyburide | The metabolism of Glyburide can be decreased when combined with Lopinavir. | Approved |
| Goserelin | Goserelin may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Granisetron | Granisetron may increase the QTc-prolonging activities of Lopinavir. | Approved, Investigational |
| Grazoprevir | The serum concentration of Grazoprevir can be increased when it is combined with Lopinavir. | Approved |
| Grepafloxacin | The metabolism of Grepafloxacin can be decreased when combined with Lopinavir. | Withdrawn |
| Guanfacine | The serum concentration of Guanfacine can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Halofantrine | The serum concentration of Halofantrine can be increased when it is combined with Lopinavir. | Approved |
| Haloperidol | Haloperidol may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Halothane | The metabolism of Halothane can be decreased when combined with Lopinavir. | Approved, Vet Approved |
| HE3286 | The serum concentration of HE3286 can be increased when it is combined with Lopinavir. | Investigational |
| Hexestrol | The serum concentration of Hexestrol can be decreased when it is combined with Lopinavir. | Withdrawn |
| Hexobarbital | The metabolism of Hexobarbital can be decreased when combined with Lopinavir. | Approved |
| Histamine | The metabolism of Histamine Phosphate can be decreased when combined with Lopinavir. | Approved, Investigational |
| Histrelin | Histrelin may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Hydrocodone | The serum concentration of Hydrocodone can be decreased when it is combined with Lopinavir. | Approved, Illicit |
| Hydrocortisone | The metabolism of Hydrocortisone can be decreased when combined with Lopinavir. | Approved, Vet Approved |
| Hydromorphone | The metabolism of Hydromorphone can be decreased when combined with Lopinavir. | Approved, Illicit |
| Hydroxyprogesterone caproate | The metabolism of Hydroxyprogesterone caproate can be decreased when combined with Lopinavir. | Approved |
| Hydroxyzine | Hydroxyzine may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Ibandronate | Ibandronate may increase the QTc-prolonging activities of Lopinavir. | Approved, Investigational |
| Ibrutinib | The serum concentration of Ibrutinib can be increased when it is combined with Lopinavir. | Approved |
| Ibuprofen | The metabolism of Ibuprofen can be increased when combined with Lopinavir. | Approved |
| Ibutilide | Ibutilide may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Idarubicin | The metabolism of Idarubicin can be decreased when combined with Lopinavir. | Approved |
| Idelalisib | The serum concentration of Lopinavir can be increased when it is combined with Idelalisib. | Approved |
| Ifosfamide | The serum concentration of the active metabolites of Ifosfamide can be reduced when Ifosfamide is used in combination with Lopinavir resulting in a loss in efficacy. | Approved |
| Iloperidone | The serum concentration of the active metabolites of Iloperidone can be increased when Iloperidone is used in combination with Lopinavir. | Approved |
| Imatinib | The serum concentration of Imatinib can be increased when it is combined with Lopinavir. | Approved |
| Imidafenacin | The serum concentration of Imidafenacin can be increased when it is combined with Lopinavir. | Approved |
| Imipramine | The metabolism of Imipramine can be decreased when combined with Lopinavir. | Approved |
| Imiquimod | The metabolism of Imiquimod can be decreased when combined with Lopinavir. | Approved, Investigational |
| Indacaterol | The metabolism of Indacaterol can be decreased when combined with Lopinavir. | Approved |
| Indapamide | The metabolism of Indapamide can be decreased when combined with Lopinavir. | Approved |
| Indinavir | The metabolism of Lopinavir can be decreased when combined with Indinavir. | Approved |
| Indomethacin | The metabolism of Indomethacin can be increased when combined with Lopinavir. | Approved, Investigational |
| Insulin Aspart | The therapeutic efficacy of Insulin Aspart can be decreased when used in combination with Lopinavir. | Approved |
| Insulin Detemir | The therapeutic efficacy of Insulin Detemir can be decreased when used in combination with Lopinavir. | Approved |
| Insulin Glargine | The therapeutic efficacy of Insulin Glargine can be decreased when used in combination with Lopinavir. | Approved |
| Insulin Glulisine | The therapeutic efficacy of Insulin Glulisine can be decreased when used in combination with Lopinavir. | Approved |
| Insulin Lispro | The therapeutic efficacy of Insulin Lispro can be decreased when used in combination with Lopinavir. | Approved |
| Insulin Pork | The therapeutic efficacy of Insulin Pork can be decreased when used in combination with Lopinavir. | Approved |
| Ipratropium bromide | The metabolism of Ipratropium bromide can be decreased when combined with Lopinavir. | Approved |
| Irbesartan | The metabolism of Irbesartan can be decreased when combined with Lopinavir. | Approved, Investigational |
| Irinotecan | The serum concentration of the active metabolites of Irinotecan can be increased when Irinotecan is used in combination with Lopinavir. | Approved, Investigational |
| Isavuconazonium | The serum concentration of the active metabolites of Isavuconazonium can be increased when Isavuconazonium is used in combination with Lopinavir. | Approved, Investigational |
| Isoflurane | Isoflurane may increase the QTc-prolonging activities of Lopinavir. | Approved, Vet Approved |
| Isosorbide Dinitrate | The metabolism of Isosorbide Dinitrate can be decreased when combined with Lopinavir. | Approved |
| Isosorbide Mononitrate | The metabolism of Isosorbide Mononitrate can be decreased when combined with Lopinavir. | Approved |
| Isradipine | The metabolism of Isradipine can be decreased when combined with Lopinavir. | Approved |
| Itraconazole | The serum concentration of Itraconazole can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Ivabradine | The serum concentration of Ivabradine can be increased when it is combined with Lopinavir. | Approved |
| Ivacaftor | The serum concentration of Ivacaftor can be increased when it is combined with Lopinavir. | Approved |
| Ivermectin | The metabolism of Ivermectin can be decreased when combined with Lopinavir. | Approved, Vet Approved |
| Ixabepilone | The serum concentration of Ixabepilone can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Ixazomib | The metabolism of Ixazomib can be decreased when combined with Lopinavir. | Approved |
| Ketamine | The metabolism of Ketamine can be decreased when combined with Lopinavir. | Approved, Vet Approved |
| Ketazolam | The metabolism of Ketazolam can be decreased when combined with Lopinavir. | Approved |
| Ketobemidone | The metabolism of Ketobemidone can be decreased when combined with Lopinavir. | Approved |
| Ketoconazole | The serum concentration of Lopinavir can be increased when it is combined with Ketoconazole. | Approved, Investigational |
| Ketoconazole | The metabolism of Lopinavir can be decreased when combined with Ketoconazole. | Approved, Investigational |
| Labetalol | The metabolism of Labetalol can be decreased when combined with Lopinavir. | Approved |
| Lacosamide | The serum concentration of Lacosamide can be increased when it is combined with Lopinavir. | Approved |
| Lamivudine | The serum concentration of Lamivudine can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Lamotrigine | The serum concentration of Lamotrigine can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Lansoprazole | The metabolism of Lansoprazole can be decreased when combined with Lopinavir. | Approved, Investigational |
| Lapatinib | The serum concentration of Lapatinib can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Laquinimod | The metabolism of Laquinimod can be decreased when combined with Lopinavir. | Investigational |
| Ledipasvir | The serum concentration of Ledipasvir can be increased when it is combined with Lopinavir. | Approved |
| Lenalidomide | The serum concentration of Lenalidomide can be increased when it is combined with Lopinavir. | Approved |
| Lenvatinib | Lenvatinib may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Lercanidipine | The serum concentration of Lercanidipine can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Letrozole | The metabolism of Letrozole can be decreased when combined with Lopinavir. | Approved, Investigational |
| Leuprolide | Leuprolide may increase the QTc-prolonging activities of Lopinavir. | Approved, Investigational |
| Levetiracetam | The serum concentration of Levetiracetam can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Levobupivacaine | The serum concentration of Levobupivacaine can be increased when it is combined with Lopinavir. | Approved |
| Levocetirizine | The metabolism of Levocetirizine can be decreased when combined with Lopinavir. | Approved |
| Levodopa | The metabolism of Levodopa can be decreased when combined with Lopinavir. | Approved |
| Levofloxacin | Levofloxacin may increase the QTc-prolonging activities of Lopinavir. | Approved, Investigational |
| Levomethadyl Acetate | The metabolism of Levomethadyl Acetate can be decreased when combined with Lopinavir. | Approved |
| Levomilnacipran | The serum concentration of Levomilnacipran can be increased when it is combined with Lopinavir. | Approved |
| Levonorgestrel | The serum concentration of Levonorgestrel can be decreased when it is combined with Lopinavir. | Approved, Investigational |
| Levothyroxine | The metabolism of Levothyroxine can be decreased when combined with Lopinavir. | Approved |
| Licofelone | The metabolism of Licofelone can be decreased when combined with Lopinavir. | Investigational |
| Lidocaine | The metabolism of Lidocaine can be decreased when combined with Lopinavir. | Approved, Vet Approved |
| Linagliptin | The serum concentration of Linagliptin can be increased when it is combined with Lopinavir. | Approved |
| Liraglutide | The therapeutic efficacy of Liraglutide can be decreased when used in combination with Lopinavir. | Approved |
| Lisuride | The metabolism of Lisuride can be decreased when combined with Lopinavir. | Approved |
| Lithium | Lithium may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Lomitapide | The serum concentration of Lomitapide can be increased when it is combined with Lopinavir. | Approved |
| Lomustine | The metabolism of Lomustine can be decreased when combined with Lopinavir. | Approved |
| Loperamide | The metabolism of Loperamide can be decreased when combined with Lopinavir. | Approved |
| Loratadine | The metabolism of Loratadine can be decreased when combined with Lopinavir. | Approved |
| Lorcaserin | The metabolism of Lorcaserin can be decreased when combined with Lopinavir. | Approved |
| Losartan | The metabolism of Losartan can be decreased when combined with Lopinavir. | Approved |
| Lovastatin | The serum concentration of Lovastatin can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Luliconazole | The serum concentration of Lopinavir can be increased when it is combined with Luliconazole. | Approved |
| Lumacaftor | The metabolism of Lopinavir can be increased when combined with Lumacaftor. | Approved |
| Lumefantrine | The serum concentration of Lumefantrine can be increased when it is combined with Lopinavir. | Approved |
| Lumiracoxib | The metabolism of Lumiracoxib can be increased when combined with Lopinavir. | Approved, Investigational |
| Lurasidone | The serum concentration of Lurasidone can be increased when it is combined with Lopinavir. | Approved |
| Macitentan | The serum concentration of Macitentan can be increased when it is combined with Lopinavir. | Approved |
| Mannitol | The serum concentration of Mannitol can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Maprotiline | Maprotiline may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Maraviroc | The serum concentration of Maraviroc can be increased when it is combined with Lopinavir. | Approved, Investigational |
| ME-609 | The serum concentration of ME-609 can be increased when it is combined with Lopinavir. | Investigational |
| Mebendazole | The metabolism of Mebendazole can be decreased when combined with Lopinavir. | Approved, Vet Approved |
| Medroxyprogesterone acetate | The serum concentration of Medroxyprogesterone acetate can be decreased when it is combined with Lopinavir. | Approved, Investigational |
| Medrysone | The serum concentration of Medrysone can be increased when it is combined with Lopinavir. | Approved |
| Mefenamic acid | The metabolism of Mefenamic acid can be decreased when combined with Lopinavir. | Approved |
| Mefloquine | The metabolism of Mefloquine can be decreased when combined with Lopinavir. | Approved |
| Melatonin | The metabolism of Melatonin can be increased when combined with Lopinavir. | Approved, Nutraceutical, Vet Approved |
| Meloxicam | The metabolism of Meloxicam can be decreased when combined with Lopinavir. | Approved, Vet Approved |
| Mephenytoin | The metabolism of Mephenytoin can be decreased when combined with Lopinavir. | Investigational, Withdrawn |
| Meprobamate | The metabolism of Meprobamate can be increased when combined with Lopinavir. | Approved, Illicit |
| Mequitazine | The serum concentration of Mequitazine can be increased when it is combined with Lopinavir. | Approved |
| Mesoridazine | The metabolism of Mesoridazine can be decreased when combined with Lopinavir. | Approved |
| Mestranol | The serum concentration of Mestranol can be decreased when it is combined with Lopinavir. | Approved |
| Metformin | The therapeutic efficacy of Metformin can be decreased when used in combination with Lopinavir. | Approved |
| Methadone | Methadone may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Methallenestril | The serum concentration of Methallenestril can be decreased when it is combined with Lopinavir. | Experimental |
| Methamphetamine | The metabolism of Methamphetamine can be decreased when combined with Lopinavir. | Approved, Illicit |
| Methaqualone | The metabolism of Methaqualone can be decreased when combined with Lopinavir. | Illicit, Withdrawn |
| Methotrexate | The serum concentration of Methotrexate can be increased when it is combined with Lopinavir. | Approved |
| Methotrimeprazine | Methotrimeprazine may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Methoxsalen | The metabolism of Methoxsalen can be decreased when combined with Lopinavir. | Approved |
| Methoxyflurane | The metabolism of Methoxyflurane can be decreased when combined with Lopinavir. | Approved, Vet Approved |
| Methsuximide | The metabolism of Methsuximide can be increased when combined with Lopinavir. | Approved |
| Methylphenidate | The metabolism of Methylphenidate can be decreased when combined with Lopinavir. | Approved, Investigational |
| Methylphenobarbital | The metabolism of Methylphenobarbital can be increased when combined with Lopinavir. | Approved |
| Methylprednisolone | The serum concentration of Methylprednisolone can be increased when it is combined with Lopinavir. | Approved, Vet Approved |
| Methyltestosterone | The metabolism of Methyltestosterone can be decreased when combined with Lopinavir. | Approved |
| Methyprylon | The metabolism of Methyprylon can be decreased when combined with Lopinavir. | Approved, Illicit, Withdrawn |
| Metoclopramide | Metoclopramide may increase the QTc-prolonging activities of Lopinavir. | Approved, Investigational |
| Metoprolol | The serum concentration of Metoprolol can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Metronidazole | The metabolism of Metronidazole can be decreased when combined with Lopinavir. | Approved |
| Metronidazole | The risk or severity of adverse effects can be increased when Metronidazole is combined with Lopinavir. | Approved |
| Mexiletine | The metabolism of Mexiletine can be decreased when combined with Lopinavir. | Approved |
| Mianserin | The metabolism of Mianserin can be decreased when combined with Lopinavir. | Approved |
| Mibefradil | The metabolism of Mibefradil can be decreased when combined with Lopinavir. | Withdrawn |
| Miconazole | The metabolism of Miconazole can be decreased when combined with Lopinavir. | Approved, Investigational, Vet Approved |
| Midazolam | The serum concentration of Midazolam can be increased when it is combined with Lopinavir. | Approved, Illicit |
| Mifepristone | Mifepristone may increase the QTc-prolonging activities of Lopinavir. | Approved, Investigational |
| Miglitol | The therapeutic efficacy of Miglitol can be decreased when used in combination with Lopinavir. | Approved |
| Miglustat | The therapeutic efficacy of Miglustat can be decreased when used in combination with Lopinavir. | Approved |
| Minaprine | The metabolism of Minaprine can be decreased when combined with Lopinavir. | Approved |
| Mirabegron | The metabolism of Mirabegron can be decreased when combined with Lopinavir. | Approved |
| Mirtazapine | The metabolism of Mirtazapine can be decreased when combined with Lopinavir. | Approved |
| Mitiglinide | The therapeutic efficacy of Mitiglinide can be decreased when used in combination with Lopinavir. | Approved, Investigational |
| Mitotane | The serum concentration of Lopinavir can be decreased when it is combined with Mitotane. | Approved |
| Mitoxantrone | The serum concentration of Mitoxantrone can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Moclobemide | The metabolism of Moclobemide can be decreased when combined with Lopinavir. | Approved |
| Modafinil | The metabolism of Modafinil can be decreased when combined with Lopinavir. | Approved, Investigational |
| Moexipril | Moexipril may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Mometasone | The serum concentration of Mometasone can be increased when it is combined with Lopinavir. | Approved, Vet Approved |
| Montelukast | The metabolism of Montelukast can be decreased when combined with Lopinavir. | Approved |
| Morphine | The metabolism of Morphine can be decreased when combined with Lopinavir. | Approved, Investigational |
| Moxifloxacin | Moxifloxacin may increase the QTc-prolonging activities of Lopinavir. | Approved, Investigational |
| Mycophenolate mofetil | The metabolism of Mycophenolate mofetil can be decreased when combined with Lopinavir. | Approved, Investigational |
| Nadolol | The serum concentration of Nadolol can be increased when it is combined with Lopinavir. | Approved |
| Nafcillin | The serum concentration of Lopinavir can be decreased when it is combined with Nafcillin. | Approved |
| Naloxegol | The serum concentration of Naloxegol can be increased when it is combined with Lopinavir. | Approved |
| Naloxone | The metabolism of Naloxone can be decreased when combined with Lopinavir. | Approved, Vet Approved |
| Naproxen | The metabolism of Naproxen can be decreased when combined with Lopinavir. | Approved, Vet Approved |
| Nateglinide | The metabolism of Nateglinide can be decreased when combined with Lopinavir. | Approved, Investigational |
| NCX 1022 | The serum concentration of NCX 1022 can be increased when it is combined with Lopinavir. | Investigational |
| Nebivolol | The serum concentration of Nebivolol can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Nefazodone | The serum concentration of Nefazodone can be increased when it is combined with Lopinavir. | Approved, Withdrawn |
| Nelfinavir | The serum concentration of Lopinavir can be decreased when it is combined with Nelfinavir. | Approved |
| Netupitant | The serum concentration of Lopinavir can be increased when it is combined with Netupitant. | Approved |
| Nevirapine | The serum concentration of Lopinavir can be decreased when it is combined with Nevirapine. | Approved |
| Nicardipine | The metabolism of Nicardipine can be decreased when combined with Lopinavir. | Approved |
| Nicergoline | The metabolism of Nicergoline can be decreased when combined with Lopinavir. | Approved |
| Nicotine | The metabolism of Nicotine can be decreased when combined with Lopinavir. | Approved |
| Nifedipine | The metabolism of Nifedipine can be decreased when combined with Lopinavir. | Approved |
| Nilotinib | The serum concentration of Nilotinib can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Nilutamide | The metabolism of Nilutamide can be increased when combined with Lopinavir. | Approved |
| Nilvadipine | The metabolism of Nilvadipine can be decreased when combined with Lopinavir. | Approved |
| Nimodipine | The serum concentration of Nimodipine can be increased when it is combined with Lopinavir. | Approved |
| Nintedanib | The serum concentration of Nintedanib can be increased when it is combined with Lopinavir. | Approved |
| Nisoldipine | The serum concentration of Nisoldipine can be increased when it is combined with Lopinavir. | Approved |
| Nitrazepam | The metabolism of Nitrazepam can be decreased when combined with Lopinavir. | Approved |
| Nitrendipine | The metabolism of Nitrendipine can be decreased when combined with Lopinavir. | Approved |
| Nitrofural | The metabolism of Nitrofural can be decreased when combined with Lopinavir. | Approved, Vet Approved |
| Nizatidine | The serum concentration of Nizatidine can be increased when it is combined with Lopinavir. | Approved |
| Norelgestromin | The serum concentration of Norelgestromin can be decreased when it is combined with Lopinavir. | Approved |
| Norethisterone | The metabolism of Norethisterone can be decreased when combined with Lopinavir. | Approved |
| Norfloxacin | Norfloxacin may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Norgestimate | The serum concentration of Norgestimate can be decreased when it is combined with Lopinavir. | Approved |
| Norgestrel | The serum concentration of Norgestrel can be decreased when it is combined with Lopinavir. | Approved |
| Nortriptyline | The metabolism of Nortriptyline can be decreased when combined with Lopinavir. | Approved |
| Octreotide | Octreotide may increase the QTc-prolonging activities of Lopinavir. | Approved, Investigational |
| Ofloxacin | Ofloxacin may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Olanzapine | Olanzapine may increase the QTc-prolonging activities of Lopinavir. | Approved, Investigational |
| Olaparib | The serum concentration of Olaparib can be increased when it is combined with Lopinavir. | Approved |
| Oleoyl estrone | The serum concentration of Oleoyl estrone can be increased when it is combined with Lopinavir. | Investigational |
| Olodaterol | Olodaterol may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Olopatadine | The metabolism of Olopatadine can be decreased when combined with Lopinavir. | Approved |
| Ombitasvir | The serum concentration of Ombitasvir can be increased when it is combined with Lopinavir. | Approved |
| Omeprazole | The metabolism of Omeprazole can be decreased when combined with Lopinavir. | Approved, Investigational, Vet Approved |
| Ondansetron | Ondansetron may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Orphenadrine | The metabolism of Orphenadrine can be decreased when combined with Lopinavir. | Approved |
| Osimertinib | The serum concentration of Osimertinib can be increased when it is combined with Lopinavir. | Approved |
| Ospemifene | The serum concentration of Ospemifene can be increased when it is combined with Lopinavir. | Approved |
| Oxazepam | The metabolism of Oxazepam can be decreased when combined with Lopinavir. | Approved |
| Oxiconazole | The metabolism of Oxiconazole can be increased when combined with Lopinavir. | Approved |
| Oxybutynin | The serum concentration of Oxybutynin can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Oxycodone | The risk or severity of adverse effects can be increased when Lopinavir is combined with Oxycodone. | Approved, Illicit, Investigational |
| Oxymorphone | The metabolism of Oxymorphone can be decreased when combined with Lopinavir. | Approved, Investigational, Vet Approved |
| Oxytocin | Oxytocin may increase the QTc-prolonging activities of Lopinavir. | Approved, Vet Approved |
| Paclitaxel | The metabolism of Paclitaxel can be decreased when combined with Lopinavir. | Approved, Vet Approved |
| Palbociclib | The serum concentration of Palbociclib can be increased when it is combined with Lopinavir. | Approved |
| Paliperidone | Paliperidone may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Palonosetron | The metabolism of Palonosetron can be decreased when combined with Lopinavir. | Approved, Investigational |
| Panobinostat | The serum concentration of Panobinostat can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Pantoprazole | The metabolism of Pantoprazole can be decreased when combined with Lopinavir. | Approved |
| Paramethadione | The metabolism of Paramethadione can be decreased when combined with Lopinavir. | Approved |
| Paramethasone | The metabolism of Paramethasone can be decreased when combined with Lopinavir. | Approved |
| Parecoxib | The serum concentration of Parecoxib can be increased when it is combined with Lopinavir. | Approved |
| Paricalcitol | The serum concentration of Paricalcitol can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Paritaprevir | The serum concentration of Paritaprevir can be increased when it is combined with Lopinavir. | Approved |
| Paroxetine | Paroxetine may increase the QTc-prolonging activities of Lopinavir. | Approved, Investigational |
| Pasireotide | Pasireotide may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Pazopanib | The serum concentration of Pazopanib can be increased when it is combined with Lopinavir. | Approved |
| Pentamidine | Pentamidine may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Pentobarbital | The metabolism of Lopinavir can be increased when combined with Pentobarbital. | Approved, Vet Approved |
| Perampanel | The metabolism of Perampanel can be decreased when combined with Lopinavir. | Approved |
| Perflutren | Perflutren may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Pergolide | The metabolism of Pergolide can be decreased when combined with Lopinavir. | Approved, Vet Approved, Withdrawn |
| Perhexiline | The metabolism of Perhexiline can be decreased when combined with Lopinavir. | Approved |
| Permethrin | The metabolism of Permethrin can be decreased when combined with Lopinavir. | Approved, Investigational |
| Perphenazine | The metabolism of Perphenazine can be decreased when combined with Lopinavir. | Approved |
| Pethidine | The risk or severity of adverse effects can be increased when Lopinavir is combined with Pethidine. | Approved |
| Phenacetin | The metabolism of Phenacetin can be decreased when combined with Lopinavir. | Withdrawn |
| Phenformin | The metabolism of Phenformin can be decreased when combined with Lopinavir. | Approved, Withdrawn |
| Phenobarbital | The serum concentration of Lopinavir can be decreased when it is combined with Phenobarbital. | Approved |
| Phenoxybenzamine | The metabolism of Phenoxybenzamine can be decreased when combined with Lopinavir. | Approved |
| Phenprocoumon | The metabolism of Phenprocoumon can be decreased when combined with Lopinavir. | Approved |
| Phenytoin | The serum concentration of Lopinavir can be decreased when it is combined with Phenytoin. | Approved, Vet Approved |
| Pilocarpine | The metabolism of Pilocarpine can be decreased when combined with Lopinavir. | Approved |
| Pimecrolimus | The metabolism of Pimecrolimus can be decreased when combined with Lopinavir. | Approved, Investigational |
| Pimozide | The serum concentration of Pimozide can be increased when it is combined with Lopinavir. | Approved |
| Pindolol | The metabolism of Pindolol can be decreased when combined with Lopinavir. | Approved |
| Pioglitazone | The serum concentration of Pioglitazone can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Piperazine | The metabolism of Piperazine can be decreased when combined with Lopinavir. | Approved, Vet Approved |
| Pipotiazine | The metabolism of Pipotiazine can be decreased when combined with Lopinavir. | Approved |
| Piroxicam | The metabolism of Piroxicam can be decreased when combined with Lopinavir. | Approved, Investigational |
| Pitavastatin | The metabolism of Pitavastatin can be decreased when combined with Lopinavir. | Approved |
| Podofilox | The metabolism of Podofilox can be decreased when combined with Lopinavir. | Approved |
| Pomalidomide | The metabolism of Pomalidomide can be decreased when combined with Lopinavir. | Approved |
| Ponatinib | The serum concentration of Ponatinib can be increased when it is combined with Lopinavir. | Approved |
| Posaconazole | The metabolism of Lopinavir can be decreased when combined with Posaconazole. | Approved, Investigational, Vet Approved |
| Pramlintide | The therapeutic efficacy of Pramlintide can be decreased when used in combination with Lopinavir. | Approved, Investigational |
| Pranlukast | The serum concentration of Pranlukast can be increased when it is combined with Lopinavir. | Approved |
| Prasterone | The metabolism of Prasterone can be decreased when combined with Lopinavir. | Approved, Nutraceutical |
| Prasterone sulfate | The serum concentration of dehydroepiandrosterone sulfate can be increased when it is combined with Lopinavir. | Investigational |
| Prasugrel | The serum concentration of the active metabolites of Prasugrel can be reduced when Prasugrel is used in combination with Lopinavir resulting in a loss in efficacy. | Approved |
| Pravastatin | The metabolism of Pravastatin can be decreased when combined with Lopinavir. | Approved |
| Prazepam | The metabolism of Prazepam can be decreased when combined with Lopinavir. | Approved, Illicit |
| Praziquantel | The metabolism of Praziquantel can be decreased when combined with Lopinavir. | Approved, Vet Approved |
| Prazosin | The serum concentration of Prazosin can be increased when it is combined with Lopinavir. | Approved |
| Prednicarbate | The serum concentration of Prednicarbate can be increased when it is combined with Lopinavir. | Approved |
| Prednisolone | The metabolism of Prednisolone can be decreased when combined with Lopinavir. | Approved, Vet Approved |
| Prednisolone | The serum concentration of Prednisolone can be increased when it is combined with Lopinavir. | Approved, Vet Approved |
| Prednisone | The serum concentration of Prednisone can be increased when it is combined with Lopinavir. | Approved, Vet Approved |
| Pregnenolone | The serum concentration of Pregnenolone can be increased when it is combined with Lopinavir. | Experimental |
| Primaquine | Primaquine may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Primidone | The metabolism of Lopinavir can be increased when combined with Primidone. | Approved, Vet Approved |
| Procainamide | Procainamide may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Prochlorperazine | The metabolism of Prochlorperazine can be decreased when combined with Lopinavir. | Approved, Vet Approved |
| Progesterone | The metabolism of Progesterone can be decreased when combined with Lopinavir. | Approved, Vet Approved |
| Proguanil | The metabolism of Proguanil can be decreased when combined with Lopinavir. | Approved |
| Promazine | Promazine may increase the QTc-prolonging activities of Lopinavir. | Approved, Vet Approved |
| Promethazine | Promethazine may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Propafenone | The serum concentration of Propafenone can be increased when it is combined with Lopinavir. | Approved |
| Propofol | The metabolism of Propofol can be decreased when combined with Lopinavir. | Approved, Investigational, Vet Approved |
| Propranolol | The metabolism of Propranolol can be decreased when combined with Lopinavir. | Approved, Investigational |
| Protriptyline | Protriptyline may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Prucalopride | The serum concentration of Prucalopride can be increased when it is combined with Lopinavir. | Approved |
| Pseudoephedrine | The metabolism of Pseudoephedrine can be decreased when combined with Lopinavir. | Approved |
| Pyrazinamide | The metabolism of Pyrazinamide can be decreased when combined with Lopinavir. | Approved |
| Quazepam | The metabolism of Quazepam can be decreased when combined with Lopinavir. | Approved, Illicit |
| Quetiapine | The serum concentration of Quetiapine can be increased when it is combined with Lopinavir. | Approved |
| Quinacrine | The metabolism of Quinacrine can be decreased when combined with Lopinavir. | Approved |
| Quinidine | Lopinavir may increase the QTc-prolonging activities of Quinidine. | Approved |
| Quinine | The serum concentration of Quinine can be decreased when it is combined with Lopinavir. | Approved |
| Rabeprazole | The metabolism of Rabeprazole can be decreased when combined with Lopinavir. | Approved, Investigational |
| Raloxifene | The metabolism of Raloxifene can be decreased when combined with Lopinavir. | Approved, Investigational |
| Ramelteon | The serum concentration of Ramelteon can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Ranitidine | The metabolism of Ranitidine can be decreased when combined with Lopinavir. | Approved |
| Ranolazine | The serum concentration of Ranolazine can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Reboxetine | The metabolism of Reboxetine can be decreased when combined with Lopinavir. | Approved, Investigational |
| Regorafenib | The serum concentration of Regorafenib can be increased when it is combined with Lopinavir. | Approved |
| Remoxipride | The metabolism of Remoxipride can be decreased when combined with Lopinavir. | Approved, Withdrawn |
| Repaglinide | The serum concentration of Repaglinide can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Reserpine | The serum concentration of Reserpine can be increased when it is combined with Lopinavir. | Approved |
| Retapamulin | The serum concentration of Retapamulin can be increased when it is combined with Lopinavir. | Approved |
| Rifabutin | The serum concentration of the active metabolites of Rifabutin can be increased when Rifabutin is used in combination with Lopinavir. | Approved |
| Rifampicin | The risk or severity of adverse effects can be increased when Rifampicin is combined with Lopinavir. | Approved |
| Rifapentine | The metabolism of Lopinavir can be increased when combined with Rifapentine. | Approved |
| Rifaximin | The serum concentration of Rifaximin can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Rilpivirine | The serum concentration of Rilpivirine can be increased when it is combined with Lopinavir. | Approved |
| Rimexolone | The serum concentration of Rimexolone can be increased when it is combined with Lopinavir. | Approved |
| Rimonabant | The metabolism of Rimonabant can be decreased when combined with Lopinavir. | Approved, Investigational |
| Riociguat | The serum concentration of Riociguat can be increased when it is combined with Lopinavir. | Approved |
| Risperidone | The metabolism of Risperidone can be decreased when combined with Lopinavir. | Approved, Investigational |
| Ritonavir | The serum concentration of Ritonavir can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Rivaroxaban | The metabolism of Rivaroxaban can be decreased when combined with Lopinavir. | Approved |
| Rofecoxib | The metabolism of Rofecoxib can be decreased when combined with Lopinavir. | Investigational, Withdrawn |
| Rolapitant | The metabolism of Rolapitant can be decreased when combined with Lopinavir. | Approved |
| Romidepsin | The serum concentration of Romidepsin can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Ropinirole | The metabolism of Ropinirole can be decreased when combined with Lopinavir. | Approved, Investigational |
| Ropivacaine | The metabolism of Ropivacaine can be decreased when combined with Lopinavir. | Approved |
| Rosiglitazone | The metabolism of Rosiglitazone can be decreased when combined with Lopinavir. | Approved, Investigational |
| Rosuvastatin | The serum concentration of Rosuvastatin can be increased when it is combined with Lopinavir. | Approved |
| Rotigotine | The metabolism of Rotigotine can be decreased when combined with Lopinavir. | Approved |
| Roxithromycin | The metabolism of Roxithromycin can be decreased when combined with Lopinavir. | Approved, Withdrawn |
| Ruxolitinib | The serum concentration of Ruxolitinib can be increased when it is combined with Lopinavir. | Approved |
| Salbutamol | Salbutamol may increase the QTc-prolonging activities of Lopinavir. | Approved, Vet Approved |
| Salicylic acid | The serum concentration of Salicylic acid can be increased when it is combined with Lopinavir. | Approved, Vet Approved |
| Salmeterol | The serum concentration of Salmeterol can be increased when it is combined with Lopinavir. | Approved |
| Saquinavir | Saquinavir may increase the QTc-prolonging activities of Lopinavir. | Approved, Investigational |
| Saxagliptin | The serum concentration of Saxagliptin can be increased when it is combined with Lopinavir. | Approved |
| Selegiline | The metabolism of Selegiline can be decreased when combined with Lopinavir. | Approved, Investigational, Vet Approved |
| Selexipag | The metabolism of Selexipag can be decreased when combined with Lopinavir. | Approved |
| Sertindole | The metabolism of Sertindole can be decreased when combined with Lopinavir. | Approved, Withdrawn |
| Sertraline | The metabolism of Sertraline can be decreased when combined with Lopinavir. | Approved |
| Sevoflurane | The metabolism of Sevoflurane can be decreased when combined with Lopinavir. | Approved, Vet Approved |
| Sibutramine | The metabolism of Sibutramine can be decreased when combined with Lopinavir. | Approved, Illicit, Investigational, Withdrawn |
| Sildenafil | The serum concentration of Sildenafil can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Silodosin | The serum concentration of Silodosin can be increased when it is combined with Lopinavir. | Approved |
| Siltuximab | The serum concentration of Lopinavir can be decreased when it is combined with Siltuximab. | Approved |
| Simeprevir | The serum concentration of Simeprevir can be increased when it is combined with Lopinavir. | Approved |
| Simvastatin | The serum concentration of Simvastatin can be increased when it is combined with Lopinavir. | Approved |
| Sirolimus | The metabolism of Sirolimus can be decreased when combined with Lopinavir. | Approved, Investigational |
| Sitagliptin | The metabolism of Sitagliptin can be decreased when combined with Lopinavir. | Approved, Investigational |
| Sofosbuvir | The serum concentration of Sofosbuvir can be increased when it is combined with Lopinavir. | Approved |
| Solifenacin | The metabolism of Solifenacin can be decreased when combined with Lopinavir. | Approved |
| Sonidegib | The serum concentration of Sonidegib can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Sorafenib | The serum concentration of Sorafenib can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Sotalol | Sotalol may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Sparfloxacin | The serum concentration of Sparfloxacin can be increased when it is combined with Lopinavir. | Approved |
| Sparteine | The metabolism of Sparteine can be decreased when combined with Lopinavir. | Experimental |
| Sphingosine | The serum concentration of Sphingosine can be increased when it is combined with Lopinavir. | Experimental |
| Spiramycin | The metabolism of Spiramycin can be decreased when combined with Lopinavir. | Approved |
| St. John's Wort | The metabolism of Lopinavir can be increased when combined with St. John's Wort. | Nutraceutical |
| Stiripentol | The serum concentration of Lopinavir can be increased when it is combined with Stiripentol. | Approved |
| Sufentanil | The metabolism of Sufentanil can be decreased when combined with Lopinavir. | Approved, Investigational |
| Sulfadiazine | The metabolism of Sulfadiazine can be decreased when combined with Lopinavir. | Approved, Vet Approved |
| Sulfamethoxazole | The metabolism of Sulfamethoxazole can be decreased when combined with Lopinavir. | Approved |
| Sulfinpyrazone | The metabolism of Sulfinpyrazone can be decreased when combined with Lopinavir. | Approved |
| Sulfisoxazole | Sulfisoxazole may increase the QTc-prolonging activities of Lopinavir. | Approved, Vet Approved |
| Sulodexide | The therapeutic efficacy of Sulodexide can be decreased when used in combination with Lopinavir. | Approved, Investigational |
| Sunitinib | The metabolism of Sunitinib can be decreased when combined with Lopinavir. | Approved, Investigational |
| Suvorexant | The serum concentration of Suvorexant can be increased when it is combined with Lopinavir. | Approved |
| Synthetic Conjugated Estrogens, A | The metabolism of Synthetic Conjugated Estrogens, A can be decreased when combined with Lopinavir. | Approved |
| Synthetic Conjugated Estrogens, B | The metabolism of Synthetic Conjugated Estrogens, B can be decreased when combined with Lopinavir. | Approved |
| Tacrolimus | The metabolism of Tacrolimus can be decreased when combined with Lopinavir. | Approved, Investigational |
| Tadalafil | The serum concentration of Tadalafil can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Tamoxifen | The serum concentration of the active metabolites of Tamoxifen can be reduced when Tamoxifen is used in combination with Lopinavir resulting in a loss in efficacy. | Approved |
| Tamsulosin | The serum concentration of Tamsulosin can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Tapentadol | The metabolism of Tapentadol can be decreased when combined with Lopinavir. | Approved |
| Tasimelteon | The serum concentration of Tasimelteon can be increased when it is combined with Lopinavir. | Approved |
| Tasosartan | The metabolism of Tasosartan can be decreased when combined with Lopinavir. | Approved |
| Taurocholic Acid | The serum concentration of Taurocholic Acid can be increased when it is combined with Lopinavir. | Experimental |
| Tazarotene | The metabolism of Tazarotene can be decreased when combined with Lopinavir. | Approved, Investigational |
| Technetium Tc-99m sestamibi | The serum concentration of Technetium Tc-99m sestamibi can be increased when it is combined with Lopinavir. | Approved |
| Tegaserod | The metabolism of Tegaserod can be decreased when combined with Lopinavir. | Investigational, Withdrawn |
| Telaprevir | The serum concentration of Telaprevir can be decreased when it is combined with Lopinavir. | Withdrawn |
| Telavancin | Telavancin may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Telithromycin | Telithromycin may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Temazepam | The metabolism of Temazepam can be decreased when combined with Lopinavir. | Approved |
| Temsirolimus | The risk or severity of adverse effects can be increased when Lopinavir is combined with Temsirolimus. | Approved |
| Teniposide | The metabolism of Teniposide can be decreased when combined with Lopinavir. | Approved |
| Tenofovir disoproxil | Lopinavir may increase the nephrotoxic activities of Tenofovir. | Approved, Investigational |
| Terbinafine | The metabolism of Terbinafine can be decreased when combined with Lopinavir. | Approved, Investigational, Vet Approved |
| Terbutaline | Terbutaline may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Terfenadine | The serum concentration of Terfenadine can be increased when it is combined with Lopinavir. | Withdrawn |
| Tesmilifene | The metabolism of Tesmilifene can be decreased when combined with Lopinavir. | Investigational |
| Testosterone | The metabolism of Testosterone can be decreased when combined with Lopinavir. | Approved, Investigational |
| Tetrabenazine | The serum concentration of Tetrabenazine can be increased when it is combined with Lopinavir. | Approved |
| Tetracycline | The metabolism of Tetracycline can be decreased when combined with Lopinavir. | Approved, Vet Approved |
| Thalidomide | The metabolism of Thalidomide can be increased when combined with Lopinavir. | Approved, Investigational, Withdrawn |
| Theophylline | The metabolism of Theophylline can be decreased when combined with Lopinavir. | Approved |
| Thioridazine | The serum concentration of Thioridazine can be increased when it is combined with Lopinavir. | Withdrawn |
| Thiotepa | The metabolism of Thiotepa can be decreased when combined with Lopinavir. | Approved |
| Thiothixene | Thiothixene may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Tiagabine | The metabolism of Tiagabine can be decreased when combined with Lopinavir. | Approved |
| Tianeptine | The serum concentration of Tianeptine can be increased when it is combined with Lopinavir. | Approved |
| Ticagrelor | The serum concentration of the active metabolites of Ticagrelor can be reduced when Ticagrelor is used in combination with Lopinavir resulting in a loss in efficacy. | Approved |
| Ticlopidine | The metabolism of Ticlopidine can be decreased when combined with Lopinavir. | Approved |
| Timolol | The metabolism of Timolol can be decreased when combined with Lopinavir. | Approved |
| Tinidazole | The metabolism of Tinidazole can be decreased when combined with Lopinavir. | Approved, Investigational |
| Tiotropium | The metabolism of Tiotropium can be decreased when combined with Lopinavir. | Approved |
| Tipranavir | The serum concentration of Lopinavir can be decreased when it is combined with Tipranavir. | Approved, Investigational |
| Tixocortol | The serum concentration of Tixocortol can be increased when it is combined with Lopinavir. | Approved |
| Tizanidine | Tizanidine may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Tocilizumab | The serum concentration of Lopinavir can be decreased when it is combined with Tocilizumab. | Approved |
| Tofacitinib | The serum concentration of Tofacitinib can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Tolazamide | The therapeutic efficacy of Tolazamide can be decreased when used in combination with Lopinavir. | Approved |
| Tolbutamide | The metabolism of Tolbutamide can be increased when combined with Lopinavir. | Approved |
| Tolterodine | The serum concentration of Tolterodine can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Tolvaptan | The serum concentration of Tolvaptan can be increased when it is combined with Lopinavir. | Approved |
| Topotecan | The serum concentration of Topotecan can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Torasemide | The metabolism of Torasemide can be decreased when combined with Lopinavir. | Approved |
| Toremifene | The risk or severity of adverse effects can be increased when Lopinavir is combined with Toremifene. | Approved, Investigational |
| Trabectedin | The serum concentration of Trabectedin can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Tramadol | The serum concentration of Tramadol can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Trastuzumab emtansine | The serum concentration of the active metabolites of Trastuzumab emtansine can be increased when Trastuzumab emtansine is used in combination with Lopinavir. | Approved |
| Trazodone | Lopinavir may increase the QTc-prolonging activities of Trazodone. | Approved, Investigational |
| Treprostinil | The serum concentration of Treprostinil can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Tretinoin | The metabolism of Tretinoin can be decreased when combined with Lopinavir. | Approved, Investigational, Nutraceutical |
| Triamcinolone | The metabolism of Triamcinolone can be decreased when combined with Lopinavir. | Approved, Vet Approved |
| Triazolam | The serum concentration of Triazolam can be increased when it is combined with Lopinavir. | Approved |
| Trimethadione | The metabolism of Trimethadione can be decreased when combined with Lopinavir. | Approved |
| Trimethoprim | The metabolism of Trimethoprim can be decreased when combined with Lopinavir. | Approved, Vet Approved |
| Trimipramine | The metabolism of Trimipramine can be decreased when combined with Lopinavir. | Approved |
| Triptorelin | Triptorelin may increase the QTc-prolonging activities of Lopinavir. | Approved, Vet Approved |
| Troglitazone | The metabolism of Troglitazone can be decreased when combined with Lopinavir. | Withdrawn |
| Udenafil | The metabolism of Udenafil can be decreased when combined with Lopinavir. | Approved, Investigational |
| Ulipristal | The serum concentration of Ulipristal can be increased when it is combined with Lopinavir. | Approved |
| Umeclidinium | The metabolism of Umeclidinium can be decreased when combined with Lopinavir. | Approved |
| Valdecoxib | The metabolism of Valdecoxib can be decreased when combined with Lopinavir. | Investigational, Withdrawn |
| Valproic Acid | The serum concentration of Valproic Acid can be decreased when it is combined with Lopinavir. | Approved, Investigational |
| Vandetanib | Lopinavir may increase the QTc-prolonging activities of Vandetanib. | Approved |
| Vanoxerine | The metabolism of Vanoxerine can be decreased when combined with Lopinavir. | Investigational |
| Vardenafil | The serum concentration of Vardenafil can be increased when it is combined with Lopinavir. | Approved |
| Vecuronium | The serum concentration of Vecuronium can be increased when it is combined with Lopinavir. | Approved |
| Vemurafenib | The serum concentration of Vemurafenib can be increased when it is combined with Lopinavir. | Approved |
| Venetoclax | The metabolism of Venetoclax can be decreased when combined with Lopinavir. | Approved |
| Venlafaxine | The metabolism of Venlafaxine can be decreased when combined with Lopinavir. | Approved |
| Verapamil | The metabolism of Verapamil can be decreased when combined with Lopinavir. | Approved |
| Vilanterol | The metabolism of Vilanterol can be decreased when combined with Lopinavir. | Approved |
| Vilazodone | The serum concentration of Vilazodone can be increased when it is combined with Lopinavir. | Approved |
| Vildagliptin | The therapeutic efficacy of Vildagliptin can be decreased when used in combination with Lopinavir. | Approved, Investigational |
| Vinblastine | The serum concentration of Vinblastine can be increased when it is combined with Lopinavir. | Approved |
| Vincristine | The serum concentration of Vincristine can be increased when it is combined with Lopinavir. | Approved, Investigational |
| Vindesine | The serum concentration of Vindesine can be increased when it is combined with Lopinavir. | Approved |
| Vinorelbine | The metabolism of Vinorelbine can be decreased when combined with Lopinavir. | Approved, Investigational |
| Vismodegib | The metabolism of Vismodegib can be decreased when combined with Lopinavir. | Approved |
| Voglibose | The therapeutic efficacy of Voglibose can be decreased when used in combination with Lopinavir. | Approved, Investigational |
| Vorapaxar | The serum concentration of Vorapaxar can be increased when it is combined with Lopinavir. | Approved |
| Voriconazole | The serum concentration of Voriconazole can be decreased when it is combined with Lopinavir. | Approved, Investigational |
| Vorinostat | Vorinostat may increase the QTc-prolonging activities of Lopinavir. | Approved, Investigational |
| Vortioxetine | The serum concentration of Vortioxetine can be increased when it is combined with Lopinavir. | Approved |
| Warfarin | The serum concentration of Warfarin can be decreased when it is combined with Lopinavir. | Approved |
| Yohimbine | The metabolism of Yohimbine can be decreased when combined with Lopinavir. | Approved, Vet Approved |
| Zafirlukast | The metabolism of Zafirlukast can be decreased when combined with Lopinavir. | Approved, Investigational |
| Zalcitabine | The metabolism of Zalcitabine can be decreased when combined with Lopinavir. | Approved |
| Zaleplon | The metabolism of Zaleplon can be decreased when combined with Lopinavir. | Approved, Illicit, Investigational |
| Zidovudine | The serum concentration of Zidovudine can be decreased when it is combined with Lopinavir. | Approved |
| Zileuton | The metabolism of Zileuton can be decreased when combined with Lopinavir. | Approved, Investigational, Withdrawn |
| Ziprasidone | Ziprasidone may increase the QTc-prolonging activities of Lopinavir. | Approved |
| Zolpidem | The metabolism of Zolpidem can be decreased when combined with Lopinavir. | Approved |
| Zomepirac | The metabolism of Zomepirac can be decreased when combined with Lopinavir. | Withdrawn |
| Zonisamide | The metabolism of Zonisamide can be decreased when combined with Lopinavir. | Approved, Investigational |
| Zopiclone | The serum concentration of Zopiclone can be increased when it is combined with Lopinavir. | Approved |
| Zuclopenthixol | The serum concentration of Zuclopenthixol can be increased when it is combined with Lopinavir. | Approved, Investigational |
