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Displaying drugs 276 - 300 of 11479 in total

Linaclotide

Linaclotide is a synthetic 14-amino acid cyclic peptide and first-in-class guanylate cyclase-C (G-CC) agonist.[A260271, L47211] Linaclotide is structurally related to human guanylin and uroguanylin, paracrine peptide hormones that are endogenous activators of GC-C. It is also a homolog of a heat-stable enterotoxin derived from Escherichia coli, the first natural ligand...
Approved
Matched Description: … (G-CC) agonist. ... [A260276] It is also a homolog of a heat-stable enterotoxin derived from _Escherichia coli_, the first ... Linaclotide is a synthetic 14-amino acid cyclic peptide [A260271] and first-in-class guanylate cyclase-C …

Polyethylene glycol 300

Polyethylene glycol 300 (PEG 300) is a water-miscible polyether with an average molecular weight of 300 g/mol. It is a clear viscous liquid at room temperature with non-volatile, stable properties . Polyethylene glycols are widely used in biochemistry, structural biology, and medicine in addition to pharmaceutical and chemical industries. They...
Approved
Matched Description: … It is a clear viscous liquid at room temperature with non-volatile, stable properties [A33116]. ... Polyethylene glycol 300 (PEG 300) is a water-miscible polyether with an average molecular weight of 300 ... PEG 300 is found in eye drops as a lubricant to temporarily relieve redness, burning and irritation of …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Hydroxyethyl ethylcellulose

Hydroxyethyl ethylcellulose modulates bacterial binding to salivary pellicle; moderately effective in preventing plaque formation.
Approved
Experimental
Matched Categories: … Compounds used in a research, industrial, or household setting …

Dichromate

Approved
Investigational
Matched Categories: … Compounds used in a research, industrial, or household setting …

Ibuprofen

Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally patented in 1961 and...
Approved
Matched Description: … [A39076] On the available products, ibuprofen is administered as a racemic mixture. ... Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered ... is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a …
Matched Mixtures name: … Ibuprofen Cold and Sinus A P J …

Digoxin

Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also...
Approved
Matched Iupac: … yl]oxy}-4-hydroxy-6-methyloxan-2-yl]oxy}-3a,11-dihydroxy-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a] …
Matched Description: … [A178225] It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. ... [A178234] Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. ... [A178237,A178240] Prior to this, a Welsh family, historically referred to as the _Physicians of Myddvai …
Matched Categories: … BSEP/ABCB11 Substrates with a Narrow Therapeutic Index ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Compounds used in a research, industrial, or household setting ... Drugs that are Mainly Renally Excreted with a Narrow Therapeutic Index …

Sulfamethoxazole

Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria. It is generally given in combination with trimethoprim, which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps in the biosynthesis of nucleic acids and...
Approved
Matched Description: … Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis ... [L11830] It is generally given in combination with [trimethoprim], which inhibits a sequential step in ... [L11830] In this combination, sulfamethoxazole is useful for the treatment of a variety of bacterial …
Matched Mixtures name: … CO - STAR ... CO - STAR D/S ... CO-PRIMAZOL SUSPENSION …

Ferric carboxymaltose

Ferric carboxymaltose is an iron replacement product and, chemically, an iron-carbohydrate complex. It was FDA approved on July 25, 2013.
Approved
Matched Categories: … Compounds used in a research, industrial, or household setting …

Nickel sulfate

Nickel sulfate is used in allergenic testing.
Approved
Experimental
Matched Categories: … Compounds used in a research, industrial, or household setting …

Tegafur-uracil

Tegafur-uracil is an anti-tumor compound containing tegafur (1-(2-tetrahydrofuryl)-5-fluorouracil) and uracil in a molar ratio of 1:4. It was developed as an anti-cancer therapy by Taiho Pharmaceutical Co Ltd. It is approved in different countries but it is not yet approved by the FDA, Health Canada or EMA.
Approved
Investigational
Matched Description: … It was developed as an anti-cancer therapy by Taiho Pharmaceutical Co Ltd. ... Tegafur-uracil is an anti-tumor compound containing tegafur (1-(2-tetrahydrofuryl)-5-fluorouracil) and uracil in a …

Digitoxin

A cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665)
Approved
Investigational
Matched Iupac: … methyloxan-2-yl]oxy}-4-hydroxy-6-methyloxan-2-yl]oxy}-3a-hydroxy-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a] …
Matched Description: … A cardiac glycoside sometimes used in place of digoxin. ... It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Compounds used in a research, industrial, or household setting ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Neisseria meningitidis group Y capsular polysaccharide tetanus toxoid conjugate antigen

Approved

VidPrevtyn Beta

VidPrevtyn Beta is an adjuvanted, recombinant COVID-19 vaccine developed collaboratively by GlaxoSmithKline (GSK) and Sanofi Pasteur. It comprises a recombinant SARS-CoV-2 spike protein (B.1.351 strain) - produced by recombinant DNA technology using a baculovirus expression system in an insect cell line that is derived from Sf9 cells of the fall...
Approved
Investigational
Matched Description: … booster dose in patients who have previously received a COVID-19 vaccine. ... [L49691] It comprises a recombinant SARS-CoV-2 spike protein (B.1.351 strain) - produced by recombinant ... DNA technology using a baculovirus expression system in an insect cell line that is derived from Sf9 …

Tedizolid phosphate

Drug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and penicillin-resistant Streptococcus penumoniae, represent a massive public health threat.[A199086, A199131] Tedizolid is a member of the oxazolidinone class of antibiotics, which includes the previously approved linezolid and is generally effective against multidrug-resistant Gram-positive bacteria. Tedizolid is indicated for the...
Approved
Matched Description: … [A199086, A199131] Tedizolid is a member of the oxazolidinone class of antibiotics, which includes the ... vancomycin-resistant _Enterococcus faecium_, and penicillin-resistant _Streptococcus penumoniae_, represent a ... This product is currently available as both an oral tablet and as a powder for intravenous injection. …
Matched Categories: … Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates …

Astemizole

Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice.
Approved
Withdrawn
Matched Description: … Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy …
Matched Categories: … BSEP/ABCB11 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A7 Substrates with a Narrow Therapeutic Index …

Romidepsin

Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy.
Approved
Investigational
Matched Description: … Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2B6 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index …

Ivabradine

Ivabradine is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis and symptomatic chronic heart failure. Ivabradine, brand name Corlanor, was approved by the FDA in April 2015 for the treatment of chronic heart failure in patients with an ejection fraction of ≤35%, in sinus...
Approved
Matched Description: … Ivabradine is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis ... Recently a new indication was added to treat symptomatic heart failure from dilated cardiomyopathy for ... dose-dependent fashion, resulting in a lower heart rate and thus more blood to flow to the myocardium …

Cotton

Cotton allergenic extract is used in allergenic testing.
Approved

Pyrethrum extract

Pyrethrum is the crude extract form obtained from flowers of the plant Chrysanthemum cinerariifolium. Pyrethrin refers to a more refined extract of pyrethrum. While pyrethrum extract is composed of 6 esters, both organic compounds mediate insecticidal activities. Pyrethrum-containing mixtures are used as a common insecticide to control specific pest species....
Approved
Matched Description: … Pyrethrin refers to a more refined extract of pyrethrum. ... Pyrethrum-containing mixtures are used as a common insecticide to control specific pest species. …
Matched Mixtures name: … Mata Piojos A Pediculicide Low Foaming …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Sodium hydroxide

Sodium hydroxide is also known as lye or soda , or caustic soda . At room temperature, sodium hydroxide is a white crystalline odorless solid that absorbs moisture from the air. It is a synthetically manufactured substance. When dissolved in water or neutralized with acid it releases substantial amounts of...
Approved
Matched Description: … Sodium hydroxide is generally used as a solid or a diluted in a 50% solution. ... It is a synthetically manufactured substance. ... as a pH control agent and follows good manufacturing guidelines [L1967]. …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Potassium hydroxide

Potassium hydroxide, also known as lye is an inorganic compound with the chemical formula KOH. Also commonly referred to as caustic potash, it is a potent base that is marketed in several forms including pellets, flakes, and powders. It is used in various chemical, industrial and manufacturing applications. Potassium hydroxide...
Approved
Matched Description: … Potassium hydroxide is used in food to adjust pH, as a stabilizer, and as a thickening agent. ... Potassium hydroxide is also a precursor to other potassium compounds. ... Also commonly referred to as _caustic potash_, it is a potent base that is marketed in several forms …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Hetacillin

Hetacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Hetacillin has in vitro activity against gram-positive and gram-negative...
Approved
Vet approved
Withdrawn
Matched Description: … Hetacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused …

Phenprocoumon

Coumarin derivative that acts as a long-acting oral anticoagulant.
Approved
Investigational
Matched Description: … Coumarin derivative that acts as a long-acting oral anticoagulant. …
Matched Categories: … Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Conivaptan

Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2).
Approved
Investigational
Matched Description: … Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). …
Matched Categories: … Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Zanubrutinib

Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long-term survival. BTK...
Approved
Investigational
Matched Iupac: … (7S)-2-(4-phenoxyphenyl)-7-[1-(prop-2-enoyl)piperidin-4-yl]-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxamide …
Matched Description: … trial whose tumour is entirely or partially destroyed by a drug. ... Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients ... [A187967] BTK is an enzyme that plays a role in oncogenic signalling pathways, promoting the survival …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2B6 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …
Displaying drugs 276 - 300 of 11479 in total