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Displaying drugs 26 - 50 of 1155 in total

Pepsin

Pepsin is a potent enzyme in gastric juice that digests proteins such as those in meat, eggs, seeds, and dairy products . Studies on gastric digestion from 1820-1840 led to the discovery of pepsin as the substance which, in the presence of stomach acid, causes nutrients including meat or coagulated...
Approved
Experimental
Investigational
Matched Synonyms: … Pepsin porcine …

Conestat alfa

C1 Esterase Inhibitor (Recombinant) is a recombinant analogue of endogenous complement component-1 esterase inhibitor (rhC1INH), purified from the milk of transgenic rabbits. The primary function of endogenous C1INH is to regulate the activation of the complement and contact system pathways. It does this through inhibition of several target proteases within...
Approved
Investigational
Matched Synonyms: … C1 Inhibitor (Recombinant) ... Recombinant human C1-INH ... C1 Esterase Inhibitor (Recombinant) …
Matched Description: … C1 Esterase Inhibitor (Recombinant) is a recombinant analogue of endogenous complement component-1 esterase …

Apadamtase alfa

Thrombotic thrombocytopenic purpura (TTP) is a rare blood clotting disorder characterized by thrombocytopenia, microangiopathic hemolytic anemia, and various degrees of organ damage. It may be inherited (congenital TTP; cTTP) or acquired due to autoantibodies (immune-mediated TTP; iTTP), although cTTP accounts for <5% of all cases of TTP. Patients with cTTP...
Approved
Investigational
Matched Synonyms: … ADAMTS13, recombinant-krhn ... Recombinant human adamts13 ... Metalloproteinase ADAMTS13 (human recombinant BAX930) …
Matched Description: … [A262071] Apadamtase alfa, sold under the brand name Adzynma (ADAMTS13, recombinant-krhn), was approved …
Matched Categories: … Recombinant Proteins …

Abatacept

Abatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1).[L20504,L42715] Structurally, abatacept is a glycosylated fusion protein with a MALDI-MS molecular weight of 92,300 Da and it...
Approved
Matched Synonyms: … Abatacept recombinant …
Matched Description: … It is produced through recombinant DNA technology in mammalian CHO cells. …

Moroctocog alfa

Moroctocog alfa, also known as BDDrFVIII (B domain deleted recombinant factor VIII), is a recombinant DNA-based drug with functional characteristics comparable to those of endogenous coagulation Factor VIII, the essential human blood clotting protein that is impaired in Hemophilia A. Moroctocog alfa is identical in sequence to endogenously produced Factor...
Approved
Matched Synonyms: … B-domain deleted recombinant factor VIII ... Human factor VIII, recombinant B-domain deleted ... Antihemophilic factor recombinant plasma/albumin free …
Matched Description: … Moroctocog alfa, also known as BDDrFVIII (B domain deleted recombinant factor VIII), is a recombinant ... Moroctocog alfa is produced through recombinant DNA technology and purification, resulting in a 1438 ... Clinical evaluation has shown that BDDrFVIII is pharmacokinetically equivalent to full-length recombinant …
Matched Categories: … Recombinant Proteins …

Insulin glulisine

Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the...
Approved
Matched Synonyms: … Insulin glulisine recombinant ... Insulin Glulisine (recombinant DNA origin) …
Matched Description: … This recombinant hormone differs from native human insulin in that the amino acid asparagine at position …

Efmoroctocog alfa

Efmoroctocog alfa is a fully recombinant factor VIII-Fc fusion protein (rFVIIIFc) with an extended half-life compared with conventional factor VIII (FVIII) preparations, including recombinant FVIII (rFVIII) products such as DB13999 . It is an antihemorrhagic agent used in replacement therapy for patients with haemophilia A (congenital factor VIII deficiency). It...
Approved
Investigational
Matched Synonyms: … Antihemophilic factor (recombinant, FC fusion protein) ... Antihemophilic Factor (Recombinant BDD), FC Fusion Protein ... Coagulation factor VIII recombinant immunoglubulin g1 fusion protein …
Matched Description: … Efmoroctocog alfa is a fully recombinant factor VIII-Fc fusion protein (rFVIIIFc) with an extended half-life ... compared with conventional factor VIII (FVIII) preparations, including recombinant FVIII (rFVIII) products ... products with similar structure and function to Efmoroctocog alfa include [DB13999], which is produced by recombinant …

Thyrotropin alfa

Thyrotropin alfa is a recombinant form of thyroid stimulating hormone used in performing certain tests in patients who have or have had thyroid cancer. It is also used along with a radioactive agent to destroy remaining thyroid tissue in certain patients who have had their thyroid gland removed because of...
Approved
Vet approved
Matched Synonyms: … Recombinant thyrotropin alfa ... Recombinant Human Thyroid Stimulating Hormone …
Matched Description: … Thyrotropin alfa is a recombinant form of thyroid stimulating hormone used in performing certain tests …

rhThrombin

rhThrombin (recombinant human thrombin) is being developed by ZymoGenetics, Inc. as a general aid to achieving hemostasis during surgery. ZymoGenetics is developing rhThrombin, a recombinant form of human thrombin that is not derived from animal or human blood, as an aid to controlling bleeding during surgery. Thrombin is used in...
Approved
Investigational
Matched Synonyms: … Recombinant thrombin …
Matched Description: … rhThrombin (recombinant human thrombin) is being developed by ZymoGenetics, Inc. as a general aid to ... ZymoGenetics is developing rhThrombin, a recombinant form of human thrombin that is not derived from ... The production of recombinant proteins is not dependent on the availability of blood from animals or …

Choriogonadotropin alfa

Recombinant human chorionic gonadotropin with 2 subunits, alpha = 92 residues, beta = 145 residues, each with N-and O-linked carbohydrate moieties linked to ASN-52 and ASN-78 (on alpha subunit) and ASN-13, ASN-30, SER-121, SER-127, SER-132 and SER-138 (on beta subunit). The primary structure of the alpha-chain of r-hCG is identical...
Approved
Matched Synonyms: … Chorionic gonadotropin (recombinant) …
Matched Description: … Recombinant human chorionic gonadotropin with 2 subunits, alpha = 92 residues, beta = 145 residues, each …

Nonacog beta pegol

Nonacog beta pegol is a recombinant coagulation factor IX derivative. It is produced without animal-derived materials and with an attached 40kDa polyethylene glycol (PEG) molecule for peptide activation by a site-directed glycoPEGylation. Once activated, the activation molecule with PEG is cleaved to leave the activated factor IX (Factor IXa). Nonacog...
Approved
Investigational
Matched Synonyms: … Coagulation Factor IX (Recombinant), GlycoPEGylated …
Matched Description: … Nonacog beta pegol is a recombinant coagulation factor IX derivative. …

Ocriplasmin

Ocriplasmin is a recombinant truncated form of human plasmin with a molecular weight of 27.2 kDa produced by recombinant DNA technology in a Pichia pastoris expression system. Ocriplasmin is a protein made up of 249 amino acids and has two peptide chains. Agent for pharmacologic vitreolysis; thrombolytic agent. FDA approved...
Approved
Matched Synonyms: … Recombinant human microplasmin …
Matched Description: … by recombinant DNA technology in a Pichia pastoris expression system. ... Ocriplasmin is a recombinant truncated form of human plasmin with a molecular weight of 27.2 kDa produced …

Human papillomavirus type 58 L1 capsid protein antigen

Human papillomavirus type 58 L1 capsid protein antigen is contained in Gardasil is a vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus (HPV) type 58. The vaccine is prepared from the purified...
Approved
Matched Synonyms: … Recombinant human papillomavirus type 58 L1 protein …
Matched Description: … VLPs) of the major capsid (L1) protein of HPV Type 58 which are produced by separate fermentations in recombinant …
Matched Mixtures name: … Gardasil 9 [Human Papillomavirus 9-valent Vaccine, Recombinant] …

rsPSMA Vaccine

Prostate-specific membrane antigen (PSMA) is an ∼100 kDa transmembrane glycoprotein that is abundantly and preferentially expressed in prostate cancer, including recurrent and hormone-refractory cases. rsPSMA Vaccine is a subunit vaccine based on a novel rsPSMA protein that represents the entire extracellular domain of PSMA (Schulke et al., PNAS 100:12590, 2003)....
Approved
Investigational
Matched Synonyms: … Recombinant soluble prostate-specific membrane antigen (rsPSMA) vaccine …

Neisseria meningitidis serogroup b nhba fusion protein antigen

Approved
Matched Synonyms: … Neisseria meningitidis serogroup B recombinant NHBA fusion protein antigen …

Neisseria meningitidis serogroup b nada protein antigen

Approved
Matched Synonyms: … Neisseria meningitidis serogroup B recombinant NADA fusion protein antigen …

Human papillomavirus type 11 L1 capsid protein antigen

Human papillomavirus type 11 L1 capsid protein antigen is contained in Gardasil, or a recombinant Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) vaccine for intramuscular injection. It is an immunization for young men and women 9-26 years of age for the prevention of diseases caused by Human Papillomavirus...
Approved
Matched Synonyms: … Recombinant human papillomavirus type 11 L1 protein …
Matched Description: … Human papillomavirus type 11 L1 capsid protein antigen is contained in Gardasil, or a recombinant Human ... capsid (L1) protein of HPV Types 6, 11, 16, and 18, which are produced by separate fermentations in recombinant …
Matched Mixtures name: … Gardasil 9 [Human Papillomavirus 9-valent Vaccine, Recombinant] …

Oprelvekin

Oprelvekin, the active ingredient in Neumega®, is recombinant Interleukin-11 (IL-11), which is produced in Escherichia coli (E. coli) by recombinant DNA technology. With a molecular mass of approximately 19,000 daltons, the non-glycosylated protein is 177 amino acids in length in comparison to the natural IL-11, which is 178 amino acid...
Approved
Investigational
Matched Synonyms: … Recombinant interleukin-11 …
Matched Description: … in Escherichia coli (E. coli) by recombinant DNA technology. ... Oprelvekin, the active ingredient in Neumega®, is recombinant Interleukin-11 (IL-11), which is produced …

Avalglucosidase alfa

Avalglucosidase alfa, or NeoGAA, is a drug for enzyme replacement therapy specifically designed for Pompe disease, a rare inherited neuromuscular disorder caused by the deficiency of the alpha-glucosidase (GAA) enzyme. GAA is an essential enzyme that hydrolyzes glycogen into free glucose for use in cellular functions. In Pompe disease, the...
Approved
Investigational
Matched Synonyms: … Neo-recombinant human acid alpha-glucosidase …
Matched Description: … [A232955] Avalglucosidase alfa is a recombinant form of GAA that restores deficient enzyme levels. …

Parathyroid hormone

Parathyroid hormone (PTH) is a single-chain polypeptide composed of 84 amino acids. Available as Preotact, it is an identical form of human recombinant hormome which produced as a fusion protein undergoeing post-translational processing involving the cleavage of the OmpA leader sequence, leaving the mature protein as a single-chain 84 amino-acids...
Approved
Investigational
Matched Synonyms: … Parathormone (human recombinant) ... Parathyroid hormone (1-84) human recombinant …
Matched Description: … Available as Preotact, it is an identical form of human recombinant hormome which produced as a fusion …

Triflupromazine

A phenothiazine used as an antipsychotic agent and as an antiemetic.
Approved
Vet approved
Matched Synonyms: … 2-Trifluoromethyl-10-(gamma-dimethylaminopropyl)phenothiazine …

Turoctocog alfa pegol

Turoctocog alfa pegol is a pegylated version of turoctocog alfa. Novo Nordisk's brand name Esperoct (turoctocog alfa pegol, N8-GP) was approved by the US FDA on February 19, 2019. Fundamentally, the N8-GP moiety is identical to turoctocog alfa, a recombinant human clotting factor VIII (rFVIII) with a truncated B-domain made...
Approved
Matched Synonyms: … Antihemophilic factor (recombinant), glycopegylated-exei …
Matched Description: … Fundamentally, the N8-GP moiety is identical to [turoctocog alfa], a recombinant human clotting factor …
Matched Categories: … Recombinant Proteins …

Sargramostim

Sargramostim is a human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) expressed in yeast. It is a glycoprotein that is 127 residues. Substitution of Leu23 leads to a difference from native protein.
Approved
Investigational
Matched Synonyms: … Recombinant human granulocyte-macrophage colony stimulating factor …
Matched Description: … Sargramostim is a human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) expressed …

Asparaginase Erwinia chrysanthemi

Asparaginase Erwinia chrysanthemi is an asparaginase-specific enzyme derived from Erwinia chrysanthemi used as an anticancer agent. It works by depleting the stores of an important amino acid called asparagine, which is involved in DNA synthesis and cell survival of malignant cells, leading to cell death. L-asparaginase was first identified in...
Approved
Investigational
Matched Synonyms: … Asparaginase Erwinia chrysanthemi (recombinant) ... asparaginase erwinia chrysanthemi (recombinant)-rywn …
Matched Description: … [L149] In June 2021, the recombinant form of asparaginase _Erwinia chrysanthemi_ was approved by the …

Becaplermin

Becaplermin is produced by recombinant DNA technology by insertion of the gene for the B chain of platelet derived growth factor (PDGF) into the yeast, Saccharomyces cerevisiae. Becaplermin has a molecular weight of approximately 25 KD and is a homodimer composed of two identical polypeptide chains that are bound together...
Approved
Investigational
Matched Synonyms: … Platelet-derived growth factor BB, recombinant ... Recombinant platelet-derived growth factor BB …
Matched Description: … Becaplermin is produced by recombinant DNA technology by insertion of the gene for the B chain of platelet …
Displaying drugs 26 - 50 of 1155 in total