Displaying drugs 76 - 100 of 190 in total
Ofatumumab
Ofatumumab is a novel anti-CD20 monoclonal antibody that targets B-cells. It is an IgG1κ human monoclonal antibody produced from a recombinant murine cell line (NS0) via transgenic mouse and hybridoma technology. Ofatumumab works by recognizing antigens that are expressed on the tumour cells in certain cancers; however, the antigen is...
Approved
Matched Description: … It is an IgG1κ human monoclonal antibody produced from a recombinant murine cell line (NS0) via transgenic ... works by recognizing antigens that are expressed on the tumour cells in certain cancers; however, the antigen ... mouse and hybridoma technology. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Matched Products: … İNFÜZYONLUK ÇÖZELTİ KONSATRESİ İÇEREN FLAKON (1 ADET) ... Jemvy 20 mg/0,4 mL Enjeksiyonluk Çözelti İçeren Kullanıma Hazır Kalem, 1 ADET ... JEMVY 20 MG/0,4 ML ENJEKSİYONLUK ÇÖZELTİ İÇEREN KULLANIMA HAZIR ENJEKTÖR, 1 ADET …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Matched Products: … İNFÜZYONLUK ÇÖZELTİ KONSATRESİ İÇEREN FLAKON (1 ADET) ... Jemvy 20 mg/0,4 mL Enjeksiyonluk Çözelti İçeren Kullanıma Hazır Kalem, 1 ADET ... JEMVY 20 MG/0,4 ML ENJEKSİYONLUK ÇÖZELTİ İÇEREN KULLANIMA HAZIR ENJEKTÖR, 1 ADET …
Tremelimumab
Tremelimumab, formerly known as ticilimumab, is a fully human IgG2 monoclonal antibody directed against cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4). CTLA-4 is a cell surface receptor expressed on activated T cells to act as a negative regulator for T cells. By binding to CTLA-4, tremelimumab enhances T cell-mediated killing of tumours...
Approved
Investigational
Matched Description: … cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4). ... Tremelimumab, formerly known as ticilimumab, is a fully human IgG2 monoclonal antibody directed against ... [A253717] By binding to CTLA-4, tremelimumab enhances T cell-mediated killing of tumours and reduces …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Basiliximab
A recombinant chimeric (murine/human) monoclonal antibody (IgG1k) that functions as an immunosuppressive agent, specifically binding to and blocking the interleukin-2 receptor a-chain (IL-2R alpha, also known as CD25 antigen) on the surface of activated T-lymphocytes. It is a 144 kDa glycoprotein obtained from fermentation of an established mouse myeloma cell...
Approved
Investigational
Matched Description: … as CD25 antigen) on the surface of activated T-lymphocytes. ... heavy and light chain constant region genes and mouse heavy and light chain variable region genes encoding ... A recombinant chimeric (murine/human) monoclonal antibody (IgG1k) that functions as an immunosuppressive …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Products: … SIMULECT 20 MG İNFÜZYON VEYA ENJEKSİYONLUK ÇÖZELTİ İÇİN TOZ VE ÇÖZÜCÜ, 1 ADET …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Products: … SIMULECT 20 MG İNFÜZYON VEYA ENJEKSİYONLUK ÇÖZELTİ İÇİN TOZ VE ÇÖZÜCÜ, 1 ADET …
Hydrocortisone valerate
Approved
Vet approved
Matched Iupac: … ,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl pentanoate ... (1R,3aS,3bS,9aR,9bS,10S,11aS)-10-hydroxy-1-(2-hydroxyacetyl)-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H …
Matched Categories: … 11-Hydroxycorticosteroids ... Hydrocortisone and derivatives ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Categories: … 11-Hydroxycorticosteroids ... Hydrocortisone and derivatives ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Atorvastatin
Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase,...
Approved
Matched Iupac: … (3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-(propan-2-yl)-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic …
Matched Description: … coronary death) for every 1 mmol/L reduction in LDL without any significant side effects or risks. ... Bruce Roth and approved by the FDA in 1996. ... lipid levels, and ultimately reduce the risk of cardiovascular disease. …
Matched Mixtures name: … Amlodipine and atorvastatin ... Amlodipine and atorvastatin ... Amlodipine and atorvastatin …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... atorvastatin and ezetimibe ... atorvastatin and amlodipine ... atorvastatin and perindopril ... atorvastatin, amlodipine and ramipril …
Matched Products: … COLASTIN-L 10 MG FILM KAPLI TABLET, 30 ADET ... COLASTIN-L 10 MG FILM KAPLI TABLET, 90 ADET ... COLASTIN-L 20 MG FILM KAPLI TABLET, 30 ADET …
Matched Description: … coronary death) for every 1 mmol/L reduction in LDL without any significant side effects or risks. ... Bruce Roth and approved by the FDA in 1996. ... lipid levels, and ultimately reduce the risk of cardiovascular disease. …
Matched Mixtures name: … Amlodipine and atorvastatin ... Amlodipine and atorvastatin ... Amlodipine and atorvastatin …
Matched Categories: … Heterocyclic Compounds, 1-Ring ... atorvastatin and ezetimibe ... atorvastatin and amlodipine ... atorvastatin and perindopril ... atorvastatin, amlodipine and ramipril …
Matched Products: … COLASTIN-L 10 MG FILM KAPLI TABLET, 30 ADET ... COLASTIN-L 10 MG FILM KAPLI TABLET, 90 ADET ... COLASTIN-L 20 MG FILM KAPLI TABLET, 30 ADET …
Etrasimod
Etrasimod is a synthetic next-generation selective Sphingosine 1-phosphate (S1P) receptor modulator that targets the S1P1,4,5 with no detectable activity on S1P2 and S1P3 receptors. S1P receptors are membrane-derived lysophospholipid signaling molecules that are involved in the sequestration of circulating peripheral lymphocytes in lymph nodes. Therefore, S1P receptor modulators like etrasimod...
Approved
Matched Description: … Etrasimod is a synthetic next-generation selective Sphingosine 1-phosphate (S1P) receptor modulator that ... [A261826] In fact, it has been observed that antigen-activated T cells within peripheral lymphoid organs ... 26% remission rate observed in UC 52 and UC 12 trials respectively. …
Alemtuzumab
Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant regions, and complementarity-determining regions from a...
Approved
Investigational
Matched Description: … The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant regions, and ... [L43397] It is marketed as LEMTRADA for multiple sclerosis (MS) treatment and CAMPTAH for B-cell chronic ... The dose of alemtuzumab used for B-CLL is much higher than that for MS, and also at more frequent dosing …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Products: … MABCAMPATH INF SOL ICIN 30 MG/ML KONS 1 ML 3 FLK (10 MG/ML KONSANTRE 3 AMP) ... LEMTRADA 12 MG /1.2 ML İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 1 ADET …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Products: … MABCAMPATH INF SOL ICIN 30 MG/ML KONS 1 ML 3 FLK (10 MG/ML KONSANTRE 3 AMP) ... LEMTRADA 12 MG /1.2 ML İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 1 ADET …
Hydrocortisone probutate
Approved
Vet approved
Matched Iupac: … ,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl butanoate ... (1R,3aS,3bS,9aR,9bS,10S,11aS)-10-hydroxy-9a,11a-dimethyl-7-oxo-1-[2-(propanoyloxy)acetyl]-1H,2H,3H,3aH …
Matched Categories: … 11-Hydroxycorticosteroids ... Hydrocortisone and derivatives ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Categories: … 11-Hydroxycorticosteroids ... Hydrocortisone and derivatives ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Hydrocortisone cypionate
Approved
Investigational
Vet approved
Matched Iupac: … 9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1- …
Matched Categories: … 11-Hydroxycorticosteroids ... Hydrocortisone and derivatives ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Categories: … 11-Hydroxycorticosteroids ... Hydrocortisone and derivatives ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Hydrocortisone phosphate
Approved
Vet approved
Matched Iupac: … 9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1- …
Matched Categories: … 11-Hydroxycorticosteroids ... Hydrocortisone and derivatives ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Categories: … 11-Hydroxycorticosteroids ... Hydrocortisone and derivatives ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Omidubicel
Omidubicel is a nicotinamide-modified allogeneic hematopoietic progenitor cell therapy derived from cord blood used as an allogeneic stem cell donor source. Umbilical blood cord cells are expanded ex-vivo and nicotinamide (a form of vitamin B3) is used as an active agent in the culture system to inhibit the differentiation and...
Approved
Investigational
Matched Description: … leukocyte antigen (HLA)-matching. ... cancers for whom a related or unrelated donor cannot be found due to the requirement of high-grade human ... [A258938,A258943,L46048] This type of cell therapy benefits patients that require stem cell transplantation …
Zanubrutinib
Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long-term survival. BTK...
Approved
Investigational
Matched Iupac: … (7S)-2-(4-phenoxyphenyl)-7-[1-(prop-2-enoyl)piperidin-4-yl]-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine-3-carboxamide …
Matched Description: … [L39025] In October 2022, the EMA's Committee for Medicinal Products for Human Use (CHMP) recommended ... [L39030] This indication is valid in the US, Europe, and Canada. ... aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and …
Matched Categories: … Protein Kinase Inhibitors ... Heterocyclic Compounds, 1-Ring ... Antineoplastic and Immunomodulating Agents …
Matched Description: … [L39025] In October 2022, the EMA's Committee for Medicinal Products for Human Use (CHMP) recommended ... [L39030] This indication is valid in the US, Europe, and Canada. ... aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and …
Matched Categories: … Protein Kinase Inhibitors ... Heterocyclic Compounds, 1-Ring ... Antineoplastic and Immunomodulating Agents …
Ocrelizumab
Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-humanized CD20 antibodies such as rituximab, ocrelizumab is...
Approved
Investigational
Matched Description: … recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen ... inflammatory, autoimmune disease of the central nervous system that leads to neurological disabilities and ... Health Canada in August 2017, making the drug the first available treatment for PPMS in both the US and …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Products: … OCREVUS 300 MG/10 ML İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 1 ADET …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Products: … OCREVUS 300 MG/10 ML İNFÜZYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN KONSANTRE, 1 ADET …
Vibrio cholerae CVD 103-HgR strain live antigen
Vibrio cholerae CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against Vibrio cholerae serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by Vibrio cholerae, which is gram-negative bacteria. Two serogroups of V. cholerae, O1 and O139, are causative...
Approved
Investigational
Matched Name: … Vibrio cholerae CVD 103-HgR strain live antigen …
Matched Description: … _Vibrio cholerae_ CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization ... A244489] The FDA approved the cholera vaccine containing _Vibrio cholerae_ CVD 103-HgR strain live antigen ... [L39729] It is indicated for individuals aged two years and older.[L12801] …
Matched Products: … Cholera Vaccine Strain 35a-and 41 8000m/cc …
Matched Description: … _Vibrio cholerae_ CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization ... A244489] The FDA approved the cholera vaccine containing _Vibrio cholerae_ CVD 103-HgR strain live antigen ... [L39729] It is indicated for individuals aged two years and older.[L12801] …
Matched Products: … Cholera Vaccine Strain 35a-and 41 8000m/cc …
Hepatitis B immune globulin
Long-term hepatitis B immune globulin (HBIG) has been shown to reduce hepatitis B virus (HBV) reinfection in patients transplanted for hepatitis B. Infection with hepatitis B may lead to hepatocellular carcinoma, a type of liver cancer. Therefore, the hepatitis-B vaccines are cancer-preventing vaccines. According to the Centers for Disease Control...
Approved
Investigational
Matched Synonyms: … Hepatitis B immune globulin human ... Hepatitis B immune globulin (human) ... Human hepatitis B immunoglobulin …
Matched Description: … Infection with hepatitis B may lead to hepatocellular carcinoma, a type of liver cancer. ... HBIG is prepared from the plasma of donors who have high antibody levels of the hepatitis B surface antigen ... The preparation is tested for absence of HIV, HCV, herpes virus, and reovirus. …
Matched Categories: … Human Immunoglobulin ... Amino Acids, Peptides, and Proteins ... Immune Sera and Immunoglobulins …
Matched Products: … ICIN LIYOFILIZE TOZ ICEREN FLAKON, 1 ADET ... HEPAGAM B 312 IU/1 ML IM/IV ENJEKSİYONLUK/İNFÜZYONLUK ÇÖZELTİ ... HEPABULİN SN 2.000 IU/10 ML IV ENJEKSİYONLUK ÇÖZELTİ , 1 ADET …
Matched Description: … Infection with hepatitis B may lead to hepatocellular carcinoma, a type of liver cancer. ... HBIG is prepared from the plasma of donors who have high antibody levels of the hepatitis B surface antigen ... The preparation is tested for absence of HIV, HCV, herpes virus, and reovirus. …
Matched Categories: … Human Immunoglobulin ... Amino Acids, Peptides, and Proteins ... Immune Sera and Immunoglobulins …
Matched Products: … ICIN LIYOFILIZE TOZ ICEREN FLAKON, 1 ADET ... HEPAGAM B 312 IU/1 ML IM/IV ENJEKSİYONLUK/İNFÜZYONLUK ÇÖZELTİ ... HEPABULİN SN 2.000 IU/10 ML IV ENJEKSİYONLUK ÇÖZELTİ , 1 ADET …
Brentuximab vedotin
Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved in 2011. In January 2012, the...
Approved
Investigational
Matched Synonyms: … Moab, chimeric, SGN-30, to CD30 antigen …
Matched Description: … In this type of lymphoma, large, abnormal lymphocytes (a type of white blood cell) are found in the lymph ... [L1737] The ECHELON-1 study results demonstrated superior efficacy of the drug combined with a chemotherapy ... Most individuals with Hodgkin's lymphoma have the classical type. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Matched Products: … ADCETRIS 50 MG IV INFÜZYONLUK ÇÖZELTI KONSANTRESI IÇIN TOZ IÇEREN FLAKON ,FLAKON, 1 ADET …
Matched Description: … In this type of lymphoma, large, abnormal lymphocytes (a type of white blood cell) are found in the lymph ... [L1737] The ECHELON-1 study results demonstrated superior efficacy of the drug combined with a chemotherapy ... Most individuals with Hodgkin's lymphoma have the classical type. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES …
Matched Products: … ADCETRIS 50 MG IV INFÜZYONLUK ÇÖZELTI KONSANTRESI IÇIN TOZ IÇEREN FLAKON ,FLAKON, 1 ADET …
Capromab pendetide
Capromab is a Murine IgG1 monoclonal 7E11-C5.3 antibody that recognizes prostate specific membrane antigen (PSMA – also known as glutamate carboxypeptidase 2) from prostate cancer cells and normal prostate tissue. When linked to pendetide, capromab is used as a chelating agent for the radionuclide Indium In-111 during imaging to evaluate...
Approved
Matched Description: … Capromab is a Murine IgG1 monoclonal 7E11-C5.3 antibody that recognizes prostate specific membrane antigen ... (PSMA – also known as glutamate carboxypeptidase 2) from prostate cancer cells and normal prostate tissue …
Matched Categories: … Indicators and Reagents ... Amino Acids, Peptides, and Proteins …
Matched Categories: … Indicators and Reagents ... Amino Acids, Peptides, and Proteins …
Cemiplimab
Cemiplimab is a fully human monoclonal antibody that works against programmed death receptor-1 (PD-1), which is a negative regulator of T cell function. By blocking PD-1, cemiplimab works to enhance T cell-mediated antitumour responses. Cemiplimab was first approved by the FDA on September 28, 2018, as the first FDA-approved treatment...
Approved
Investigational
Matched Description: … Cemiplimab is a fully human monoclonal antibody that works against programmed death receptor-1 (PD-1) ... [A39201,A254177,L4615] It was later approved to be used in basal cell carcinoma and non-small non-small ... [L43872] In October 2022, the EMA's Committee for Medicinal Products for Human Use (CHMP) recommended …
Matched Categories: … PD-1/PDL-1 (Programmed cell death protein 1/death ligand 1) inhibitors ... Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES ... Programmed Death Receptor-1 Blocking Antibody …
Matched Categories: … PD-1/PDL-1 (Programmed cell death protein 1/death ligand 1) inhibitors ... Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents ... MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES ... Programmed Death Receptor-1 Blocking Antibody …
Alefacept
Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD.
Approved
Investigational
Withdrawn
Matched Description: … human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of ... human IgG1. ... Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the …
Matched Categories: … CD2-directed LFA-3/Fc Fusion Protein ... Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Categories: … CD2-directed LFA-3/Fc Fusion Protein ... Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Abiraterone
Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 2011, respectively. It is used to treat metastatic...
Approved
Matched Iupac: … (3aS,3bR,7S,9aR,9bS,11aS)-9a,11a-dimethyl-1-(pyridin-3-yl)-3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H, …
Matched Description: … ] and September 2011,[A260880] respectively. ... Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17 ... [L40968, L40193, L47740, L47745] As abiraterone has poor oral bioavailability and is susceptible to …
Matched Salts cas: … 154229-18-2 …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Hormone Antagonists and Related Agents ... Metabolic Side Effects of Drugs and Substances ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Matched Description: … ] and September 2011,[A260880] respectively. ... Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17 ... [L40968, L40193, L47740, L47745] As abiraterone has poor oral bioavailability and is susceptible to …
Matched Salts cas: … 154229-18-2 …
Matched Categories: … Antineoplastic and Immunomodulating Agents ... Hormone Antagonists and Related Agents ... Metabolic Side Effects of Drugs and Substances ... Hormones, Hormone Substitutes, and Hormone Antagonists …
Janssen COVID-19 Vaccine
The Janssen COVID-19 vaccine (Ad26.COV2.S) is a recombinant vaccine that contains an adenovirus serotype 26 (Ad26) vector expressing a stabilized SARS-CoV-2 spike protein. The vaccine was created in collaboration with Johnson and Johnson (J&J), Janssen Pharmaceutical, and the Beth Israel Deaconess Medical Center. A preclinical study in hamsters infected with...
Approved
Investigational
Matched Description: … , and efficacy of the ad26.COV.S vaccine in 1045 healthy adults between the ages of 18-55 (NCT04436276 ... vaccine that contains an adenovirus serotype 26 (Ad26) vector expressing a stabilized SARS-CoV-2 spike protein ... As of June 2020, a Phase 1/2 clinical trial in adult humans was announced to evaluate the safety, immunogenicity …
Tositumomab
Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine).
Approved
Investigational
Matched Description: … Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Belatacept
Belatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1). Structurally, abatacept is a glycosylated fusion protein with a MALDI-MS molecular weight of 92,300 Da and it...
Approved
Investigational
Matched Description: … antigen 4 (CTLA-4) to the modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin ... Belatacept is a soluble fusion protein, which links the extracellular domain of human cytotoxic T-lymphocyte-associated ... and it is a homodimer of two homologous polypeptide chains of 357 amino acids each. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Lutetium Lu-177 vipivotide tetraxetan
Lutetium Lu-177 vipivotide tetraxetan is a radioligand therapeutic agent. It consists of a radionuclide, lutetium Lu-177, linked to a moiety that binds to PSMA, a transmembrane protein that is expressed in prostate cancer. Lutetium Lu-177 vipivotide tetraxetan was first approved by the FDA on March 23, 2022 as a treatment...
Approved
Matched Iupac: … (177Lu)lutetium(3+) 2-[4,7-bis(carboxylatomethyl)-10-[({[(1r,4r)-4-{[(1S)-1-{[(5S)-5-carboxy-5-({[(1S ... -(naphthalen-2-yl)ethyl]carbamoyl}cyclohexyl]methyl}carbamoyl)methyl]-1,4,7,10-tetraazacyclododecan-1- …
Matched Description: … [L41290] In October 2022, the EMA's Committee for Medicinal Products for Human Use (CHMP) recommended ... consists of a radionuclide, [lutetium Lu-177], linked to a moiety that binds to PSMA, a transmembrane protein ... tetraxetan was first approved by the FDA on March 23, 2022 as a treatment for prostate-specific membrane antigen–positive …
Matched Products: … 1 Pluvicto …
Matched Description: … [L41290] In October 2022, the EMA's Committee for Medicinal Products for Human Use (CHMP) recommended ... consists of a radionuclide, [lutetium Lu-177], linked to a moiety that binds to PSMA, a transmembrane protein ... tetraxetan was first approved by the FDA on March 23, 2022 as a treatment for prostate-specific membrane antigen–positive …
Matched Products: … 1 Pluvicto …
Relatlimab
Relatlimab is a human IgG4 monoclonal antibody and novel immune checkpoint inhibitor that targets lymphocyte activation gene-3 (LAG-3).[A246165,L41265] It was the first commercially developed anti-LAG-3 antibody, entering clinical trials in 2013, and has garnered interest in the treatment of a variety of cancers, including leukemia and melanoma. As immune checkpoint...
Approved
Investigational
Matched Description: … Relatlimab is a human IgG4 monoclonal antibody and novel immune checkpoint inhibitor that targets lymphocyte ... like relatlimab have been trialed in combination with other checkpoint inhibitors - for example, PD-1 ... [A246155]
Relatlimab received FDA approval in March 2022, alongside the PD-1 inhibitor [nivolumab] …
Matched Categories: … nivolumab and relatlimab ... Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Matched Categories: … nivolumab and relatlimab ... Amino Acids, Peptides, and Proteins ... Antineoplastic and Immunomodulating Agents …
Displaying drugs 76 - 100 of 190 in total