IDPharmacologyInteractionsReferencesTrialsEconomicsPropertiesTaxonomy
Targets (1)
Targets (1)Biointeractions (1)

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Identification
NameCapromab pendetide
Accession NumberDB00089  (BTD00080, BIOD00080)
TypeBiotech
GroupsApproved
Description

Capromab is a Murine IgG1 monoclonal 7E11-C5.3 antibody that recognizes prostate specific membrane antigen (PSMA – also known as glutamate carboxypeptidase 2) from prostate cancer cells and normal prostate tissue. It is linked to pendetide, a derivative of DTPA. Pendetide acts as a chelating agent for the radionuclide indium-111. Capromab is used to image the extent of prostate cancer.

Protein structureDb00089
Related Articles
Protein chemical formulaNot Available
Protein average weightNot Available
SequencesNot Available
Synonyms
(111In)-Capromab pendetide
Indium (111In) capromab pendetide
Indium In 111 capromab pendetide
External IDs CYT-356 / Cytogen 356
Product Ingredients Not Available
Approved Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
Prostascint Kit for The Preparation Of Indium In 111 Capromab PendetideKitJazz Pharmaceuticals1996-10-28Not applicableUs
Approved Generic Prescription ProductsNot Available
Approved Over the Counter ProductsNot Available
Unapproved/Other Products Not Available
International Brands
NameCompany
ProstaScintCytogen Corp.
Brand mixturesNot Available
Categories
UNIIBDO5072GRX
CAS number145464-28-4
Pharmacology
Indication

For diagnosis of prostate cancer and detection of intra-pelvic metastases.

Structured Indications
Pharmacodynamics

Binds to the prostate-specific membrane antigen, which is a cell surface protein generally overexpressed in prostate tissues and prostate cancers. The radioactive Indium 111, which is covalently attached to the antibody, allows radiodiagnostic detection of PSMA expressing cells and tumors.

Mechanism of action

Binds selectively to cell-surface prostate-specific membrane antigen (PSMA) expressed on prostate tissues and tumors.

TargetKindPharmacological actionActionsOrganismUniProt ID
Glutamate carboxypeptidase 2Proteinyes
other/unknown
HumanQ04609 details
Related Articles
AbsorptionNot Available
Volume of distribution
  • 4 ± 2.1 L
Protein bindingNot Available
Metabolism

Most likely removed by opsonization via the reticuloendothelial system or by human antimurine antibody production

Route of elimination

Approximately 10% of the administered radioisotope dose is excreted in the urine during the 72 hours following intravenous infusion.

Half lifeNot Available
Clearance
  • 42 +/- 22 mL/hr
ToxicityNot Available
Affected organisms
  • Humans and other mammals
PathwaysNot Available
Pharmacogenomic Effects/ADRs Not Available
Interactions
Drug Interactions
DrugInteractionDrug group
G17DTThe therapeutic efficacy of G17DT can be decreased when used in combination with Capromab.Investigational
INGN 201The therapeutic efficacy of INGN 201 can be decreased when used in combination with Capromab.Investigational
INGN 225The therapeutic efficacy of INGN 225 can be decreased when used in combination with Capromab.Investigational
RindopepimutThe therapeutic efficacy of CDX-110 can be decreased when used in combination with Capromab.Investigational
SRP 299The therapeutic efficacy of SRP 299 can be decreased when used in combination with Capromab.Investigational
Food InteractionsNot Available
References
Synthesis ReferenceNot Available
General References
  1. Link [Link]
  2. Link [Link]
  3. Link [Link]
External Links
ATC CodesV09IB04 — Indium (111in) capromab pendetide
AHFS CodesNot Available
PDB Entries
FDA labelDownload (1.65 MB)
MSDSNot Available
Clinical Trials
Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedDiagnosticMalignant Neoplasm of Prostate1
Pharmacoeconomics
ManufacturersNot Available
Packagers
Dosage forms
FormRouteStrength
Kit
Prices
Unit descriptionCostUnit
Prostascint kit1584.0USD kit
DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.
PatentsNot Available
Properties
StateLiquid
Experimental Properties
PropertyValueSource
melting point (°C)61 °C (FAB fragment), 71 °C (whole mAb)Vermeer, A.W.P. & Norde, W., Biophys. J. 78:394-404 (2000)
Taxonomy
DescriptionNot Available
KingdomOrganic Compounds
Super ClassOrganic Acids
ClassCarboxylic Acids and Derivatives
Sub ClassAmino Acids, Peptides, and Analogues
Direct ParentPeptides
Alternative ParentsNot Available
SubstituentsNot Available
Molecular FrameworkNot Available
External DescriptorsNot Available

Targets

Details
1. Glutamate carboxypeptidase 2
Kind
Protein
Organism
Human
Pharmacological action
yes
Actions
other/unknown
General Function:
Tetrahydrofolyl-poly(glutamate) polymer binding
Specific Function:
Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would...
Gene Name:
FOLH1
Uniprot ID:
Q04609
Uniprot Name:
Glutamate carboxypeptidase 2
Molecular Weight:
84330.015 Da
References
  1. Smith-Jones PM, Vallabahajosula S, Goldsmith SJ, Navarro V, Hunter CJ, Bastidas D, Bander NH: In vitro characterization of radiolabeled monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen. Cancer Res. 2000 Sep 15;60(18):5237-43. [PubMed:11016653 ]
  2. Sodee DB, Nelson AD, Faulhaber PF, Maclennan GT, Resnick MI, Bakale G: Update on fused capromab pendetide imaging of prostate cancer. Clin Prostate Cancer. 2005 Mar;3(4):230-8. [PubMed:15882479 ]
  3. Gregorakis AK, Holmes EH, Murphy GP: Prostate-specific membrane antigen: current and future utility. Semin Urol Oncol. 1998 Feb;16(1):2-12. [PubMed:9508077 ]
  4. Sodee DB, Ellis RJ, Samuels MA, Spirnak JP, Poole WF, Riester C, Martanovic DM, Stonecipher R, Bellon EM: Prostate cancer and prostate bed SPECT imaging with ProstaScint: semiquantitative correlation with prostatic biopsy results. Prostate. 1998 Nov 1;37(3):140-8. [PubMed:9792131 ]
  5. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
Drug created on June 13, 2005 07:24 / Updated on June 15, 2017 16:44