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Displaying drugs 101 - 125 of 8033 in total

Gadoteridol

Gadoteridol is a macrocyclic nonionic gadolinium that provides contrast enhancement of the brain, spine, and surrounding tissues, resulting in improved visualization (compared with unenhanced MRI) of lesions with abnormal vascularity or those thought to disrupt the normal blood-brain barrier.[A263076,A263081,L49871] It was 1 of the 3 macrocyclic gadolinium-based contrast agents (GBCAs)...
Approved
Investigational
Matched Description: … Gadoteridol is a macrocyclic nonionic gadolinium that provides contrast enhancement of the brain, spine ... , and surrounding tissues, resulting in improved visualization (compared with unenhanced MRI) of lesions ... [A263076,A263081,L49871] It was 1 of the 3 macrocyclic gadolinium-based contrast agents (GBCAs) that …
Matched Categories: … Diagnostic Uses of Chemicals …

Dienestrol

Dienestrol is a synthetic, non-steroidal estrogen. It is an estrogen receptor agonist. Estrogens work partly by increasing a normal clear discharge from the vagina and making the vulva and urethra healthy. Using or applying an estrogen relieves or lessens: dryness and soreness in the vagina, itching, redness, or soreness of...
Approved
Investigational
Matched Description: … the vagina (atrophic vaginitis), and inflammation of the urethra (atrophic urethritis). ... an estrogen relieves or lessens: dryness and soreness in the vagina, itching, redness, or soreness of ... are treated with vaginal estrogens include a genital skin condition (vulvar atrophy), inflammation of …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Pyrazinamide

A pyrazine that is used therapeutically as an antitubercular agent.
Approved
Investigational
Matched Categories: … Drugs for Treatment of Tuberculosis …

Cycloserine

Antibiotic substance produced by Streptomyces garyphalus.
Approved
Matched Categories: … Drugs for Treatment of Tuberculosis …

Cyclothiazide

As a diuretic, cyclothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like cyclothiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter....
Approved
Matched Description: … the effectiveness of other antihypertensive drugs in the more severe forms of hypertension. ... reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of ... The antihypertensive mechanism of cyclothiazide is less well understood although it may be mediated through …
Matched Categories: … combinations of sulfonamides …

Dezocine

Dezocine is a partial opiate drug and is used for pain management. Dezocine is a very effective alternative to fentanyl when administered during outpatient laparoscopy, although is associated with an increased incidence of postoperative nausea.
Approved
Investigational
Matched Description: … when administered during outpatient laparoscopy, although is associated with an increased incidence of …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Chlorpheniramine

A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine.
Approved
Matched Description: … One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and …
Matched Mixtures name: … Hot Lemon Relief for Symptoms Of Cough, Cold and Flu ... Hot Lemon Relief for Symptoms Of Cough, Cold and Flu Extra Strength ... Hot Lemon Relief for Symptoms Of Cough, Cold and Flu Ultra Strength …
Matched Categories: … Combined Inhibitors of Serotonin/Norepinephrine Reuptake ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Medrogestone

Medrogestone (INN), also known as 6,17α-dimethyl-6-dehydroprogesterone, is a progestational agent derived from 17-methylprogesterone. It was conceived as an alternative for an orally effective contraceptive option. It was developed by Ayerst, approved in Canada in 1969 and its current status is cancelled post-marketing. It was never approved by the FDA.
Approved
Withdrawn
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Acetyl sulfisoxazole

Sulfisoxazole acetyl is an ester of sulfisoxazole, a broad-spectrum sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with antibacterial activity. Sulfisoxazole acetyl competes with PABA for the bacterial enzyme, dihydropteroate synthase, preventing the incorporation of PABA into dihydrofolic acid, which is the precursor of folic acid. This process causes...
Approved
Vet approved
Matched Description: … This process causes an inhibition of bacterial folic acid synthesis and de novo synthesis of purines ... of para-aminobenzoic acid (PABA) with antibacterial activity. ... PABA into dihydrofolic acid, which is the precursor of folic acid. …
Matched Categories: … combinations of sulfonamides …

Ribavirin

Producing a broad-spectrum activity against several RNA and DNA viruses, Ribavirin is a synthetic guanosine nucleoside and antiviral agent that interferes with the synthesis of viral mRNA. It is primarily indicated for use in treating hepatitis C and viral hemorrhagic fevers. HCV is a single-stranded RNA virus that is categorized...
Approved
Matched Description: … Combination therapy of ribavirin and [DB00008] results in the SVR of 44% in patients with genotype 1 ... Additionally, including ribavirin in the regimen can increase the risk of anemia. ... Ribavirin is a synthetic guanosine nucleoside and antiviral agent that interferes with the synthesis of …
Matched Categories: … Antivirals for treatment of HCV infections …

Butalbital

Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervous system (CNS) depression that ranges from...
Approved
Illicit
Matched Description: … [A177754] Butalbital has a low degree of selectivity and a narrow therapeutic index. ... Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens ... It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety …
Matched Categories: … combinations of barbiturates …

Diethylpropion

A appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category. It is also considered to be among the safest for patients with hypertension. (From AMA Drug Evaluations Annual, 1994, p2290)
Approved
Illicit
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Ioxitalamic acid

Ioxitalamate is an ionic iodinated contrast medium. It is a first-generation contrast media formed by an ionic monomer with a high osmolarity of 1500-1800 mOsm/kg. Ioxitalamic acid in the salt forms of sodium and meglumine was developed by Liebel-Flarshem Canada Inc and approved by Health Canada in 1995. Until the...
Approved
Matched Description: … [A27209] It is a first-generation contrast media formed by an ionic monomer with a high osmolarity of ... [A33006] Ioxitalamic acid in the salt forms of sodium and meglumine was developed by Liebel-Flarshem …
Matched Categories: … Diagnostic Uses of Chemicals …

Follitropin

Follitropin is a human follicle stimulating hormone (FSH) preparation of recombinant DNA origin, which consists of two non-covalently linked, non-identical glycoproteins designated as the alpha- and beta- subunits. The alpha- and beta- subunits have 92 and 111 amino acids. The alpha subunit is glycosylated at Asn 51 and Asn 78...
Approved
Matched Description: … Structural analysis shows that the amino acid sequence of follitropin beta is identical to that of natural ... Follitropin is important in the development of follicles produced by the ovaries. ... Follitropin is a human follicle stimulating hormone (FSH) preparation of recombinant DNA origin, which …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Tryptophan

An essential amino acid that is necessary for normal growth in infants and for nitrogen balance in adults. It is a precursor of indole alkaloids in plants. It is a precursor of serotonin (hence its use as an antidepressant and sleep aid). It can be a precursor to niacin, albeit...
Approved
Nutraceutical
Withdrawn
Matched Description: … It is a precursor of indole alkaloids in plants. ... It is a precursor of serotonin (hence its use as an antidepressant and sleep aid). …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Silver sulfadiazine

Silver sulfadiazine is a sulfa derivative topical antibacterial used primarily on second- and third-degree burns.
Approved
Vet approved
Matched Categories: … combinations of sulfonamides …

Gadoxetic acid

Gadoxetic acid (gadoxetate) is a paramagnetic gadolinium-containing ionic linear contrast agent in which its salt form, gadoxetate disodium, is used for intravenous injection. Ethoxybenzyl diethylenetriaminepentaacetic acid is the moiety that chelates with a gadolinium ion and forms a stable complex with it to make up the drug. Gadoxetate is a...
Approved
Matched Description: … contrast of enhancement and therefore heightening the liver parenchyma-liver tumours contrast. ... anion-transporting polypeptides (OATPs) and liver tumor cells lack OATPs, liver tumors show a lack of …
Matched Categories: … Diagnostic Uses of Chemicals …

Tedizolid phosphate

Drug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and penicillin-resistant Streptococcus penumoniae, represent a massive public health threat.[A199086, A199131] Tedizolid is a member of the oxazolidinone class of antibiotics, which includes the previously approved linezolid and is generally effective against multidrug-resistant Gram-positive bacteria. Tedizolid is indicated for the...
Approved
Matched Description: … [A199086, A199131] Tedizolid is a member of the oxazolidinone class of antibiotics, which includes the ... Tedizolid is indicated for the treatment of acute bacterial skin and skin structure infections (ABSSSI …
Matched Categories: … Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Milnacipran

Milnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and like many agents in this category was originally developed for and continues to be approved and indicated for the treatment of depression [F3928, F3934, A175786, A175951]. Furthermore, in 2009 the US FDA approved milnacipran for the additional indication of...
Approved
Investigational
Matched Description: … robust evidence of efficacy, insufficient demonstration of maintenance of effect, and other concerns ... category was originally developed for and continues to be approved and indicated for the treatment of ... somewhat increased preference for noradrenaline reuptake inhibition - which is potentially a point of …
Matched Categories: … Combined Inhibitors of Serotonin/Norepinephrine Reuptake ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Sumatriptan

Sumatriptan is a serotonin receptor agonist commonly used to treat migraines and sometimes cluster headaches.[L6793,L6796,L6799,L6805,L6808,L6811] Sumatriptan is the first of the triptans and was made available in Europe in 1991 to treat migraines. Sumatriptan was granted FDA approval on 28 December 1992.
Approved
Investigational
Matched Description: … [L6793,L6796,L6799,L6805,L6808,L6811] Sumatriptan is the first of the triptans and was made available …
Matched Categories: … combinations of sulfonamides ... Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome …

Benzocaine

Benzocaine is an ester local anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. It is commonly used for local anesthesia in many over the counter products.[L32454,L32459,L32464] Benzocaine was first used for local anesthesia in dentistry.
Approved
Investigational
Matched Description: … Benzocaine is an ester local anesthetic that acts by preventing transmission of impulses along nerve …
Matched Categories: … Esters of Aminobenzoic Acid ... Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use …

Sulfadoxine

A long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract, and malarial infections.
Approved
Investigational
Matched Categories: … combinations of sulfonamides …

Estriol

A hydroxylated metabolite of estradiol or estrone that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During pregnancy, large amount of estriol is produced by the placenta. Isomers with inversion of the hydroxyl group or groups are called epiestriol. Though estriol is...
Approved
Investigational
Vet approved
Matched Description: … Though estriol is used as part of the primarily North American phenomenon of bioidentical hormone replacement ... During pregnancy, large amount of estriol is produced by the placenta. ... Isomers with inversion of the hydroxyl group or groups are called epiestriol. …
Matched Categories: … Sex Hormones and Modulators of the Genital System …

Mafenide

Mafenide is a sulfonamide-type antimicrobial agent used to treat severe burns. It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep burns. In 1998, mafenide acetate was approved under the FDA’s accelerated approval regulations. In November 2022, the use of mafenide acetate (powder...
Approved
Vet approved
Withdrawn
Matched Description: … It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep ... In November 2022, the use of mafenide acetate (powder for 5% topical solution) was withdrawn by the FDA …
Matched Categories: … combinations of sulfonamides …

Isatuximab

Isatuximab (formerly SAR650984) is a humanized, IgG1-derived monoclonal antibody (mAb) produced from a Chinese hamster ovary (CHO) cell line.[L12099,A191799] Structurally, isatuximab is comprised of two identical immunoglobulin kappa light chains and two identical immunoglobulin gamma heavy chains. It is a cytolytic antibody targeted against CD38, a glycoprotein found on the...
Approved
Investigational
Matched Description: … [L12099,A191799] Structurally, isatuximab is comprised of two identical immunoglobulin kappa light chains ... [L12099] It is a cytolytic antibody targeted against CD38, a glycoprotein found on the surface of some ... ] isatuximab was granted Orphan Drug designation and approved on March 2nd, 2020, for the treatment of …
Matched Categories: … CD38 (Clusters of Differentiation 38) inhibitors …
Displaying drugs 101 - 125 of 8033 in total