Displaying drugs 51 - 75 of 2881 in total
Elotuzumab
Elotuzumab is a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies. Elotuzumab targets SLAMF7, also known as Signaling Lymphocytic Activation Molecule Family member 7, a cell surface glycoprotein. Elotuzumab...
Approved
Matched Synonyms: … Immunoglobulin G1, anti-(human protein CS1) (human-mouse HuLuc63 heavy chain), disulfide with human-mouse …
Matched Description: … consists of the complementary determining regions (CDR) of the mouse antibody, MuLuc63, grafted onto human …
Matched Description: … consists of the complementary determining regions (CDR) of the mouse antibody, MuLuc63, grafted onto human …
Heparin
Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor...
Approved
Investigational
Matched Description: … enzymes thrombin (factor IIa) and factor Xa. ... reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation …
Nirsevimab
Nirsevimab (MEDI8897) is a recombinant human immunoglobulin G1 kappa (IgG1ĸ) monoclonal antibody used to prevent respiratory syncytial virus (RSV) lower respiratory tract disease in neonates and infants. It binds to the prefusion conformation of the RSV F protein, a glycoprotein involved in the membrane fusion step of the viral entry...
Approved
Investigational
Matched Synonyms: … Immunoglobulin g1-kappa, anti-(human respiratory syncytial virus fusion glycoprotein f0 (protein f))human ... Immunoglobulin g1, anti-(human respiratory syncytial virus fusion protein)(human monoclonal med18897 ... monoclonal antibody.gamma.1 heavy chain (1-456) (human vh (homo sapiens ighv1-69*01(ighd)-ighj4*01 ( …
Matched Description: … Nirsevimab (MEDI8897) is a recombinant human immunoglobulin G1 kappa (IgG1ĸ) monoclonal antibody used …
Matched Description: … Nirsevimab (MEDI8897) is a recombinant human immunoglobulin G1 kappa (IgG1ĸ) monoclonal antibody used …
Hemoglobin
The respiratory protein of the red blood cells. It consists primarily of globin and heme.
Approved
Experimental
Investigational
Matched Synonyms: … Human hemoglobin …
Fondaparinux
Fondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule. It is structurally similar to polymeric glycosaminoglycan heparin and heparan sulfate (HS) when they are cleaved into monomeric units. The monomeric sequence in heparin and HS...
Approved
Investigational
Matched Description: … Fondaparinux potentiates the neutralizing action of ATIII on activated Factor X 300-fold. ... in heparin and HS is thought to form the high affinity binding site for the natural anti-coagulant factor …
Matched Categories: … Factor Xa Inhibitors ... Indirect factor Xa inhibitors …
Matched Categories: … Factor Xa Inhibitors ... Indirect factor Xa inhibitors …
Bevacizumab
There is a great deal of evidence indicating that vascular endothelial growth factor (VEGF) is important for the survival and proliferation of cancer cells.[A192939,A192837,A192891,A193275] VEGF plays an important role in angiogenesis, lymphangiogenesis, and tumor growth, which are all factors that contribute to its attractiveness as a therapeutic target for anti-cancer...
Approved
Investigational
Matched Description: … There is a great deal of evidence indicating that vascular endothelial growth factor (VEGF) is important …
Matched Categories: … Vascular Endothelial Growth Factor Inhibitor ... Vascular Endothelial Growth Factor Inhibitors ... VEGF/VEGFR (Vascular Endothelial Growth Factor) inhibitors ... Vascular Endothelial Growth Factor-directed Antibody Interactions …
Matched Categories: … Vascular Endothelial Growth Factor Inhibitor ... Vascular Endothelial Growth Factor Inhibitors ... VEGF/VEGFR (Vascular Endothelial Growth Factor) inhibitors ... Vascular Endothelial Growth Factor-directed Antibody Interactions …
Danaparoid
Danaparoid is a low-molecular-weight heparinoid with an average molecular weight of 5500 Daltons consisting of a mixture of glycosaminoglycans . The active constituents are heparan, dermatan and DB09301 , and they are isolated from the porcine intestinal mucosa [FDA Label]. Danaparoid possesses a potent antithrombic activity that works by inhibiting...
Approved
Withdrawn
Matched Description: … Xa) and activated factor II (Factor IIa). ... Danaparoid possesses a potent antithrombic activity that works by inhibiting activated factor X (Factor …
Insulin aspart
Insulin aspart is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the...
Approved
Matched Synonyms: … Insulin, aspart, human ... Insulin, aspart protamine, human …
Matched Description: … typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human ... Compared to human insulin, it has a single amino acid substitution at position B28 where proline is replaced …
Matched Description: … typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human ... Compared to human insulin, it has a single amino acid substitution at position B28 where proline is replaced …
Thyrotropin alfa
Thyrotropin alfa is a recombinant form of thyroid stimulating hormone used in performing certain tests in patients who have or have had thyroid cancer. It is also used along with a radioactive agent to destroy remaining thyroid tissue in certain patients who have had their thyroid gland removed because of...
Approved
Vet approved
Matched Synonyms: … Recombinant Human Thyroid Stimulating Hormone …
Matched Description: … The amino acid sequence of thyrotropin alfa is identical to that of human pituitary thyroid stimulating ... the stimulation of adenylate cyclase, displays close structural similarity with the alpha subunit of human …
Matched Description: … The amino acid sequence of thyrotropin alfa is identical to that of human pituitary thyroid stimulating ... the stimulation of adenylate cyclase, displays close structural similarity with the alpha subunit of human …
Cetuximab
Cetuximab is a recombinant chimeric human/mouse IgG1 monoclonal antibody that competitively binds to epidermal growth factor receptor (EGFR) and competitively inhibits the binding of epidermal growth factor (EGF). EGFR is a member of the ErbB family of receptor tyrosine kinases found in both normal and tumour cells; it is responsible...
Approved
Matched Description: … epidermal growth factor receptor (EGFR) and competitively inhibits the binding of epidermal growth factor ... Cetuximab is a recombinant chimeric human/mouse IgG1 monoclonal antibody that competitively binds to ... A228083] _In vitro_, cetuximab was shown to mediate anti-tumour effects in numerous cancer cell lines and human …
Matched Categories: … Epidermal Growth Factor Receptor Antagonist ... EGFR (Epidermal Growth Factor Receptor) inhibitors …
Matched Categories: … Epidermal Growth Factor Receptor Antagonist ... EGFR (Epidermal Growth Factor Receptor) inhibitors …
Parathyroid hormone
Parathyroid hormone (PTH) is a single-chain polypeptide composed of 84 amino acids. Available as Preotact, it is an identical form of human recombinant hormome which produced as a fusion protein undergoeing post-translational processing involving the cleavage of the OmpA leader sequence, leaving the mature protein as a single-chain 84 amino-acids...
Approved
Investigational
Matched Synonyms: … Parathormone (human recombinant) ... Parathyroid hormone (1-84) human recombinant …
Matched Description: … Available as Preotact, it is an identical form of human recombinant hormome which produced as a fusion …
Matched Description: … Available as Preotact, it is an identical form of human recombinant hormome which produced as a fusion …
Avalglucosidase alfa
Avalglucosidase alfa, or NeoGAA, is a drug for enzyme replacement therapy specifically designed for Pompe disease, a rare inherited neuromuscular disorder caused by the deficiency of the alpha-glucosidase (GAA) enzyme. GAA is an essential enzyme that hydrolyzes glycogen into free glucose for use in cellular functions. In Pompe disease, the...
Approved
Investigational
Matched Synonyms: … Neo-recombinant human acid alpha-glucosidase …
Cipaglucosidase alfa
Cipaglucosidase alfa (ATB200) is a novel recombinant human acid alpha-glucosidase (GAA) investigated for the treatment of patients with Pompe disease, a rare inherited metabolic disorder characterized by a deficiency in GAA. Other types of enzyme replacement therapy for the treatment of Pompe disease include alglucosidase alfa and avalglucosidase alfa. Cipaglucosidase...
Approved
Investigational
Matched Synonyms: … Recombinant human acid alpha-glucosidase optimized for high expression of mannose 6-phosphate …
Matched Description: … Cipaglucosidase alfa (ATB200) is a novel recombinant human acid alpha-glucosidase (GAA) investigated ... [A232955, A232960] In December 2022, the EMA's Committee for Medicinal Products for Human Use (CHMP …
Matched Description: … Cipaglucosidase alfa (ATB200) is a novel recombinant human acid alpha-glucosidase (GAA) investigated ... [A232955, A232960] In December 2022, the EMA's Committee for Medicinal Products for Human Use (CHMP …
Thalidomide
A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating the release of inflammatory mediators like tumor necrosis factor-alpha...
Approved
Investigational
Withdrawn
Matched Description: … anti-angiogenic activity through modulating the release of inflammatory mediators like tumor necrosis factor-alpha …
Matched Categories: … Tumor Necrosis Factor Blockers …
Matched Categories: … Tumor Necrosis Factor Blockers …
Beremagene geperpavec
Beremagene geperpavec is a live, replication-defective herpes simplex virus type 1 (HSV-1)-based vector therapy. Developed by Krystal Biotech, it was first approved by the FDA on May 19, 2023, for the treatment of wounds associated with dystrophic epidermolysis bullosa (DEB). DEB is caused by mutations in the COL7A1 gene that...
Approved
Matched Synonyms: … Dna (recombinant herpes simplex virus type 1 strain kos plasmid vector kb103 human collagen col7a1-specifying …
Glucagon
Glucagon is a 29 amino acid hormone used as a diagnostic aid in radiologic exams to temporarily inhibit the movement of the gastrointestinal tract and to treat severe hypoglycemia.[L7634,L7637,L7640,L7643,L8519] Glucagon raises blood sugar through activation of hepatic glucagon receptors, stimulating glycogenolysis and the release of glucose.[L7640,L7643]
Glucagon was granted FDA...
Approved
Matched Synonyms: … Glucagon, human …
Infigratinib
Infigratinib is a pan-fibroblast growth factor receptor (FGFR) kinase inhibitor. By inhibiting the FGFR pathway, which is often aberrated in cancers such as cholangiocarcinoma, infigratinib suppresses tumour growth. Cholangiocarcinoma is the most common primary malignancy affecting the biliary tract and the second most common primary hepatic malignancy. Infitratinib is a...
Approved
Investigational
Matched Description: … Infigratinib is a pan-fibroblast growth factor receptor (FGFR) kinase inhibitor. ... , unresectable locally advanced or metastatic cholangiocarcinoma in adults with a fibroblast growth factor …
Matched Categories: … Fibroblast Growth Factor 2, antagonists & inhibitors ... Receptors, Fibroblast Growth Factor, antagonists & inhibitors ... Fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitors ... Receptor, Fibroblast Growth Factor, Type 1, antagonists & inhibitors …
Matched Categories: … Fibroblast Growth Factor 2, antagonists & inhibitors ... Receptors, Fibroblast Growth Factor, antagonists & inhibitors ... Fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitors ... Receptor, Fibroblast Growth Factor, Type 1, antagonists & inhibitors …
Rotavirus vaccine
Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotarix is a live attenuated vaccine containing the...
Approved
Matched Description: … Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. ... [L1116] Rotarix is a live attenuated vaccine containing the 89-12 human strain. …
Matched Salts name: … Human Rotavirus A type G1P(8) strain RIX4414 live antigen ... Human Rotavirus A type G1P7(5) strain WI79 live antigen ... Human Rotavirus A type G2P7(5) strain SC2 live antigen ... Human Rotavirus A type G4P7(5) strain BRB live antigen ... Human Rotavirus A type G3P7(5) strain WI78 live antigen …
Matched Categories: … Complex Mixtures …
Matched Salts name: … Human Rotavirus A type G1P(8) strain RIX4414 live antigen ... Human Rotavirus A type G1P7(5) strain WI79 live antigen ... Human Rotavirus A type G2P7(5) strain SC2 live antigen ... Human Rotavirus A type G4P7(5) strain BRB live antigen ... Human Rotavirus A type G3P7(5) strain WI78 live antigen …
Matched Categories: … Complex Mixtures …
Tinzaparin
Tinzaparin is a low molecular weight heparin (LMWH), produced by enzymatic depolymerization of unfractionated heparin from porcine intestinal mucosa. It is a heterogeneous mixture of with an average molecular weight between 5500 and 7500 daltons. Tinzaparin is composed of molecules with and without a special site for high affinity binding...
Approved
Matched Description: … This complex greatly accelerates the inhibition of factor Xa. ... LMWHs are less effective at inactivating factor IIa due to their shorter length compared to unfractionated …
Dacomitinib
Dacomitinib, designed as (2E)-N-16-4-(piperidin-1-yl) but-2-enamide, is an oral highly selective quinazalone part of the second-generation tyrosine kinase inhibitors which are characterized by the irreversible binding at the ATP domain of the epidermal growth factor receptor family kinase domains. Dacomitinib was developed by Pfizer Inc and approved by the FDA on...
Approved
Investigational
Matched Description: … inhibitors which are characterized by the irreversible binding at the ATP domain of the epidermal growth factor …
Matched Categories: … Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors …
Matched Categories: … Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors …
Cenegermin
Cenegermin is a human beta-nerve growth factor (beta-ngf)-(1-118)- peptide (non-covalent dimer) produced in escherichia coli. It received European Union Approval in July 2017 for the treatment of moderate to severe neurotrophic keratitis. Cenegermin received approval from the US FDA a year later in August of 2018. Neurotrophic keratitis is a...
Approved
Investigational
Matched Description: … Cenegermin is a human beta-nerve growth factor (beta-ngf)-(1-118)- peptide (non-covalent dimer) produced …
Matched Categories: … Recombinant Human Nerve Growth Factor …
Matched Categories: … Recombinant Human Nerve Growth Factor …
Argatroban
Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant shown to both normalize platelet count in patients...
Approved
Investigational
CVac
Approved
Investigational
Matched Synonyms: … Autologous dendritic cells pulsed with recombinant human fusion protein (MUCIN1 and Glutathione S Transferase …
Kappadione
Kappadione is a Vitamin K derivative (chemically, it is menadiol sodium diphosphate), previously approved by FDA prior to 1982 and marketed by Lilly Marketing for this drug has been discontinued and is not available in North America . It has been found to have carcinogenic potential in mammalian cells as...
Approved
Aflibercept
Aflibercept is a recombinant protein composed of the binding domains of two human vascular endothelial growth factor (VEGF) receptors, VEGFR1 and VEGFR2, fused with the Fc region of human immunoglobulin gamma 1 (IgG1). Structurally, Aflibercept is a dimeric glycoprotein with a protein molecular weight of 96.9 kilo Daltons (kDa). It...
Approved
Matched Description: … growth factor (VEGF) receptors, VEGFR1 and VEGFR2, fused with the Fc region of human immunoglobulin ... Aflibercept is a recombinant protein composed of the binding domains of two human vascular endothelial …
Matched Categories: … Vascular Endothelial Growth Factor Inhibitor ... Vascular Endothelial Growth Factor Inhibitors …
Matched Categories: … Vascular Endothelial Growth Factor Inhibitor ... Vascular Endothelial Growth Factor Inhibitors …
Displaying drugs 51 - 75 of 2881 in total