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Displaying drugs 51 - 75 of 8595 in total

Cholestyramine

Cholestyramine or colestyramine is a bile acid sequestrant. Bile acid sequestrants are polymeric compounds which serve as ion exchange resins. Cholestyramine resin is quite hydrophilic, but insoluble in water.
Approved
Investigational
Matched Categories: … Anticholesteremic Agents ... Hypolipidemic Agents ... Lipid Modifying Agents ... Lipid Regulating Agents ... Lipid Modifying Agents, Plain …

Elapegademase

Elapegademase is a PEGylated recombinant adenosine deaminase. It can be defined molecularly as a genetically modified bovine adenosine deaminase with a modification in cysteine 74 for serine and with about 13 methoxy polyethylene glycol chains bound via carbonyl group in alanine and lysine residues. Elapegademase is generated in E. coli,...
Approved
Matched Description: … [F1937] Elapegademase is generated in _E. coli_, developed by Leadiant Biosciences and FDA approved on ... modification in cysteine 74 for serine and with about 13 methoxy polyethylene glycol chains bound via carbonyl group …
Matched Categories: … Pegylated agents ... Antineoplastic and Immunomodulating Agents …

Heparin

Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor...
Approved
Investigational
Matched Categories: … Heparin Group ... Hematologic Agents ... Cardiovascular Agents ... Agents causing hyperkalemia ... Fibrin Modulating Agents …

Difluprednate

Difluprednate is a topical corticosteroid indicated for the treatment of infammation and pain associated with ocular surgery. It is a butyrate ester of 6(α), 9(α)-difluoro prednisolone acetate. Difluprednate is abbreviated DFBA, or difluoroprednisolone butyrate acetate. It is indicated for treatment of endogenous anterior uveiti.
Approved
Matched Categories: … Immunosuppressive Agents ... Corticosteroids, Potent (Group III) …

Baloxavir marboxil

Baloxavir marboxil is an antiviral drug used to treat influenza. More specifically, it is a first-in-class cap-dependent endonuclease inhibitor that works to block influenza virus proliferation.[A39895, A251755] It is a prodrug of baloxavir with an improved absorption profile than its active metabolite due to the addition of a phenolic hydroxyl...
Approved
Investigational
Matched Description: … an improved absorption profile than its active metabolite due to the addition of a phenolic hydroxyl group ... [L4779] It was also approved by the European Commission on January 7, 2021.[L45241] ... [A251760] Baloxavir marboxil was first globally approved in Japan in February 2018,[A39895] followed …
Matched Categories: … Antiviral Agents ... Anti-Infective Agents …

Ergotamine

A vasoconstrictor found in ergot of Central Europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of migraine disorders.
Approved
Matched Mixtures name: … Truemed Group LLC …
Matched Categories: … Antidepressive Agents ... Adrenergic Agents ... Serotonin Agents ... Cardiovascular Agents ... Uterotonic agents …

Sutilain

Sutilain is a member of the keratase family which includes agents such as papain. It is able to dissolve the intercellular matrix which helps with desquamation. Sutilain contains proteolytic enzymes derived from Bacillus subtilis and it is available as a cream-colored odorless powder. One gram of sutilain powder contains 250,000...
Approved
Withdrawn
Matched Description: … Sutilain is a member of the keratase family which includes agents such as papain. ... [T169] Sutilain was developed by Abbott and FDA approved on June 12, 1969. …

Fluvoxamine

Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database comprised...
Approved
Investigational
Matched Categories: … Antidepressive Agents ... Antidepressive Agents, Second-Generation ... Antidepressive Agents Indicated for Depression ... Anti-Anxiety Agents ... Serotonin Agents …

Acetohydroxamic acid

Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly. It is used, in addition to antibiotics...
Approved

Iohexol

Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality.
Approved
Matched Categories: … Iodinated Contrast Agents ... Agents that reduce seizure threshold …

Dihydro-alpha-ergocryptine

Alpha-dihydroergocryptine is usually referred to the mixture of the alpha and beta dihydroergocryptine. These two compounds are differentiated in the position of a methyl group. This structural difference is due to a proteinogenic amino acid replacement from leucine to isoleucine. Both compounds are hydrogenated ergot derivatives. Alpha-dihydroergocryptine approved drug product...
Approved
Matched Description: … These two compounds are differentiated in the position of a methyl group. ... Alpha-dihydroergocryptine approved drug product is as a part of an ergoloid mixture. …

Secnidazole

Secnidazole is a second-generation 5-nitroimidazole antimicrobial agent. It is structurally related to other 5-nitroimidazoles, including DB00916 and DB00911, but displays improved oral absorption and a longer terminal elimination half-life than other drugs in this class. Secnidazole is selective against many anaerobic Gram-positive and Gram-negative bacteria as well as protozoa. Once...
Approved
Matched Description: … [A245503, A245508] In September 2017, FDA approved secnidazole under the market name Solosec for the …
Matched Categories: … Anti-Infective Agents ... Antiparasitic Agents …

Fruquintinib

Fruquintinib is a novel small-molecule anti-VEGFR that targets VEGFR-1,-2, and -3 to inhibit angiogenesis. Tumor angiogenesis is one of the most critical biological processes for increasing oxygen and nutrient supply to cancer cells, and the VEGF/VEGFR pathway is one of the most critical pathways for this phenomenon.[A262102,A262107] Indeed, oncogenic activation,...
Approved
Investigational
Matched Description: … [A262097] On November 8th, 2023, fruquintinib was approved by the FDA under the brand name Fruzaqla …

Tolbutamide

Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release insulin. Sulfonylureas increase both basal insulin...
Approved
Investigational
Matched Categories: … Diagnostic Agents ... Blood Glucose Lowering Agents ... Hypoglycemia-Associated Agents …

Miglustat

Miglustat, commonly marketed under the trade name Zavesca, is a drug used to treat Gaucher disease. It inhibits the enzyme glucosylceramide synthase, an essential enzyme for the synthesis of most glycosphingolipids. It is only used for patients who cannot be treated with enzyme replacement therapy with imiglucerase. Miglustat is now...
Approved
Matched Description: … Miglustat is now the first and only approved therapy for patients with Niemann-Pick disease type C (NP-C ... It has recently been approved for treatment of progressive neurological symptoms in adult and pediatric …
Matched Categories: … Anti-HIV Agents ... Anti-Infective Agents ... Other Miscellaneous Therapeutic Agents …

Quinupramine

Quinupramine has been approved in France under the brand name Kinupril, as an antidepressant .
Approved
Matched Description: … Quinupramine has been approved in France under the brand name Kinupril, as an antidepressant [A175003 …
Matched Categories: … Antidepressive Agents ... Antidepressive Agents, Tricyclic ... Neurotoxic agents ... Agents that produce hypertension ... Agents that reduce seizure threshold …

Flurandrenolide

A corticosteroid used topically in the treatment of various skin disorders. It is usually employed as a cream or an ointment, and is also used as a polyethylene tape with an adhesive. (From Martindale, The Extra Pharmacopoeia, 30th ed, p733)
Approved
Matched Categories: … Corticosteroids, Potent (Group III) ... Anti-Inflammatory Agents ... Immunosuppressive Agents …

Methylergometrine

A homolog of ergonovine containing one more CH2 group. (Merck Index, 11th ed)
Approved
Matched Description: … A homolog of ergonovine containing one more CH2 group. (Merck Index, 11th ed) …
Matched Categories: … Uterotonic agents ... Agents that produce hypertension ... Reproductive Control Agents …

Dimethicone

Dimethicone is a silicone oil that is also known as polydimethylsiloxane (PDMS). It has viscoelastic properties. Dimethicone is used as a surfactant, antifoaming agent, carminative in various products such as medical devices, food products, and lubricants. It is used in a number of health and beauty products including hair care...
Approved
Matched Categories: … Antifoaming Agents ... Skin and Mucous Membrane Agents …
Matched Products: … KVG Group, Inc. FXP Cracked Heel Formula …

Minoxidil

A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure.
Approved
Investigational
Matched Description: … A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance …
Matched Categories: … Antihypertensive Agents ... Hypotensive Agents ... Cardiovascular Agents ... Vasodilating Agents ... Skin and Mucous Membrane Agents …

Dibenzepin

Dibenzepin is approved for use in Europe.
Approved
Matched Description: … Dibenzepin is approved for use in Europe. …
Matched Categories: … Antidepressive Agents ... Antidepressive Agents, Tricyclic ... Neurotoxic agents ... Agents that produce hypertension ... Central Nervous System Agents …

Protriptyline

Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, protriptyline exerts a positive...
Approved
Matched Categories: … Antidepressive Agents ... Antidepressive Agents, Tricyclic ... Antidepressive Agents Indicated for Depression ... Adrenergic Agents ... Neurotoxic agents …

Niraparib

Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, fallopian tube, or...
Approved
Investigational
Matched Description: … [A253248] First approved by the FDA on March 27, 2017,[A253912] niraparib is used to treat epithelial ... [L43277] Niraparib was approved by the European Commission on November 16, 2017 [L43742] and by Health …
Matched Categories: … Antineoplastic Agents ... Antineoplastic and Immunomodulating Agents …

Copanlisib

Copanlisib is a selective pan-Class I phosphoinositide 3-kinase (PI3K) inhibitor with preferential activity against the alpha and delta isoforms. PI3K, a lipid kinase that activates downstream signalling pathways involved in cell survival and growth, that exists in different isoforms and is often overexpressed in hematological malignancies. Copanlisib was granted accelerated...
Approved
Investigational
Matched Categories: … Antineoplastic Agents ... Antineoplastic and Immunomodulating Agents …

Sacituzumab govitecan

Metastatic triple-negative breast cancer (mTNBC) is an aggressive form of breast cancer with limited treatment options involving cytotoxic chemotherapy agents. Targeted chemotherapy through the application of antibody-conjugated agents (ADCs) is a recent advance in cancer treatment. One such ADC is sacituzumab govitecan, which combines a humanized anti-trophoblast cell-surface antigen 2...
Approved
Investigational
Matched Description: … [A193653] In November 2021 and July 20 2023, sacituzumab govitecan was also approved by the European ... an aggressive form of breast cancer with limited treatment options involving cytotoxic chemotherapy agents ... [A193653] Targeted chemotherapy through the application of antibody-conjugated agents (ADCs) is a recent …
Matched Categories: … Antineoplastic Agents ... Antineoplastic and Immunomodulating Agents …
Displaying drugs 51 - 75 of 8595 in total