Dimethicone

Identification

Name
Dimethicone
Accession Number
DB11074
Type
Small Molecule
Groups
Approved
Description

Dimethicone is a silicone oil that is also known as polydimethylsiloxane (PDMS). It has viscoelastic properties. Dimethicone is used as a surfactant, antifoaming agent, carminative in various products such as medical devices, food products, and lubricants. It is used in a number of health and beauty products including hair care products such as shampoo, conditioner, leave-in conditioner, and de-tangling products. On skin, it is also observed to have moisturizing actions 6,8.

A study found that that the 100 % dimethicone product is a safe and highly effective head lice treatment for children and may serve as less toxic and less resistance-prone alternative to pesticide-containing products 3.

Synonyms
  • Dimethicone
  • Dimeticona
Product Ingredients
IngredientUNIICASInChI Key
Dimethicone 100RO266O364U9006-65-9Not applicable
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing End
28 Remedy Balancing Day MoisturizerCream0.45 mg/45mLTopicalNoTS Co.,Ltd2015-03-01Not applicableUs
28 Remedy RepairCream0.3 g/30gTopicalNoTS Co Ltd2015-03-01Not applicableUs
28 Remedy Repair 30gCream0.3 g/30gTopicalNoTS Co.,Ltd2016-01-02Not applicableUs
3ce Lip Lacquer BackstageLipstick0.76 g/6.4gTopicalNanda Co., Ltd.2016-08-01Not applicableUs
3ce Lip Lacquer Bon BonLipstick0.76 g/6.4gTopicalNanda Co., Ltd.2016-08-01Not applicableUs
3ce Lip Lacquer DahliaLipstick0.76 g/6.4gTopicalNanda Co., Ltd.2016-08-01Not applicableUs
3ce Lip Lacquer Dis CoLipstick0.76 g/6.4gTopicalNanda Co., Ltd.2016-08-01Not applicableUs
3ce Lip Lacquer FeverLipstick0.76 g/6.4gTopicalNanda Co., Ltd.2016-08-01Not applicableUs
3ce Lip Lacquer Hawaiian PinkLipstick0.76 g/6.4gTopicalNanda Co., Ltd.2016-08-01Not applicableUs
3ce Lip Lacquer Pink BoomLipstick0.76 g/6.4gTopicalNanda Co., Ltd.2016-08-01Not applicableUs
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

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  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

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Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
A + D Diaper Rash CreamDimethicone (1 %) + Zinc oxide (10 %)CreamTopicalSchering Plough2010-04-052014-07-31Canada
A AND A Diaper Rash creamDimethicone (10 mg/1g) + Zinc oxide (100 mg/1g)CreamTopicalBioZone Laboratories, Inc.2013-06-15Not applicableUs
A and DDimethicone (11.09 mg/1g) + Zinc oxide (110.09 mg/1g)CreamTopicalBayer Healthcare Llc.2009-12-25Not applicableUs
ABC Arbonne Baby Care Diaper RashDimethicone (1 g/100g) + Zinc oxide (12 g/100g)CreamTopicalArbonne International Llc2014-09-20Not applicableUs
Abc Arbonne Baby Care Diaper Rash CreamDimethicone (1 %) + Zinc oxide (12 %)CreamTopicalArbonne International Llc2014-09-25Not applicableCanada
ABC Arbonne Baby Care KitDimethicone (1 g/100g) + Zinc oxide (14.4 mg/100mL) + Zinc oxide (12 g/100g)KitTopicalArbonne International Llc2014-09-20Not applicableUs
ABC Arbonne Baby Care Little Bundles SetDimethicone (1 g/57g) + Zinc oxide (14.4 mg/100mL) + Zinc oxide (12 g/57g)KitTopicalArbonne International Llc2015-09-01Not applicableUs
ABC Arbonne Baby Care Little Bundles SetDimethicone (1 %) + Zinc oxide (12 %)Cream; KitTopicalArbonne International Llc2015-09-012016-12-21Canada
ABC Arbonne Baby Care Sample SetDimethicone (1 mg/3mL) + Zinc oxide (14.4 mg/3mL) + Zinc oxide (12 mg/3mL)KitTopicalArbonne International Llc2016-04-15Not applicableUs
AdipoWinDimethicone (5 mg/1mL) + Glycerin (60 mg/1mL)CreamTopicalSupadelixir Co Ltd2017-01-02Not applicableUs
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing End
3ce Matte Lip Crayon DubiousDimethicone (0.006 g/1g)LipstickTopicalNanda Co., Ltd.2016-08-10Not applicableUs
AQUTOP Moisturizing Signature Tone-up CreamDimethicone (0.53 g/50mL) + Adenosine (0.02 g/50mL) + Nicotinamide (1 g/50mL)CreamTopicalAlable Co., Ltd.2018-07-09Not applicableUs
BEYOND THE SHAVE For MenDimethicone (2.9 g/100mL) + Allantoin (0.5 g/100mL) + Avobenzone (3.0 g/100mL) + Homosalate (2.5 g/100mL) + Octasulfur (3.0 g/100mL) + Octisalate (5 g/100mL) + Octocrylene (2.7 g/100mL)KitTopicalRodan & Fields2017-06-01Not applicableUs
Biellee Pollen Hydra Pure Brightening CreamDimethicone (0.4 mg/50mL)CreamTopicalNsb Co., Ltd.2016-06-21Not applicableUs
Cellapy A.Repair PlusDimethicone (0.85 g/50mL) + Nicotinamide (1 g/50mL) + Panthenol (0.1 g/50mL)CreamTopicalGm Holdings Co., Ltd2017-01-04Not applicableUs
DEARSIR Aqua Shuttle Essence SkinDimethicone (0.96 g/140mL) + Glycerin (2.32 g/140mL)LiquidTopicalCelltrion Skincure Co.,ltd.2017-07-012018-12-01Us
DEARSIR Perfection FluidDimethicone (0.81 g/130mL) + Glycerin (6.50 g/130mL)CreamTopicalCelltrion Skincure Co.,ltd.2017-07-012018-12-01Us
Dr COSIGN CCE Intensive RegeneratingDimethicone (8.0 g/100mL) + Adenosine (0.04 g/100mL)LotionTopicalNaerok Resources Co., Ltd2018-10-01Not applicableUs
Dr COSIGN CCE Premium RepairDimethicone (3.0 g/100mL) + Adenosine (0.04 g/100mL)CreamTopicalNaerok Resources Co., Ltd2018-10-01Not applicableUs
Dr COSIGN CCE Soothing Recovery SerumDimethicone (3.0 g/100mL) + Adenosine (0.04 g/100mL)CreamTopicalNaerok Resources Co., Ltd2018-10-01Not applicableUs
Categories
UNII
92RU3N3Y1O
CAS number
63148-62-9
Weight
Not Available
Chemical Formula
Not Available
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

Pharmacology

Indication

Dimethicone is a colorless liquid with both cosmetic and therapeutic uses. It is used in topical creams and ointments to help distribute the active ingredients. Dimethicone is used as an anti-foaming agent, a hair and skin conditioner, and in the treatment of head lice and, as an anti-bloating/anti-flatulence agent 2, 7.

Associated Conditions
Pharmacodynamics

This drug acts as a skin protectant by helping to treat and prevent minor skin irritation due to diaper rash and seals out moisture from the diaper area. This drug temporarily protects and helps prevent chafed, chapped, cracked or windburned skin. 7.

Mechanism of action

When applied topically, dimethicone forms a layer to delay the evaporation of water 8. In the treatment of head lice dimethicone 100, the respiratory systems of head lice are targeted. NYDA works by suffocating the lice, nymphs and the embryos. The physical properties of this drug, including the viscosity and spreading property of the solution allow it to easily flow into the respiratory system of all developmental stages of the insect, causing suffocation and death of the organisms. It diffuses through the stigmata (spiracles) of the lice, into the tracheae of the head lice as well as through the aeropyles of the egg operculum. The solution then displaces oxygen. The low viscosity, volatile dimethicone enables the NYDA head lice solution to penetrate into the breathing system. Its evaporation causes the thickening of the NYDA solution. The remaining high viscosity dimethicone ultimately encloses the respiratory system and thus leading to suffocation of all stages of head lice (adult lice, larvae and eggs). This mode of action prevents the development of lice resistance by preventing the formation of new progency 9.

Studies performed using house crickets and lice suggest a close correlation between the death of the lice and the influx of the solution into the insect head tracheae. These data strongly suggest that the total filling of the head tracheae immediately blocks the oxygen supply to the insect central nervous system. Death, following numerous stages of disability after the entrance of dimethicones into the abdominal tracheal system, demonstrates the sequence of oxygen deprivation. NYDA was applied directly to the head and mouth of the organism, and was found to have no effect when applied solely to the outside of the head/mouth 9.

Additional Data Available
Adverse Effects

Comprehensive structured data on known drug adverse effects with statistical prevalence. MedDRA and ICD10 ids are provided for adverse effect conditions and symptoms.

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Additional Data Available
Contraindications

Structured data covering drug contraindications. Each contraindication describes a scenario in which the drug is not to be used. Includes restrictions on co-administration, contraindicated populations, and more.

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Additional Data Available
Blackbox Warnings

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Absorption

This drug is not believed to be absorbed when used in quantities from 1-30% Label.

Volume of distribution

Following injection of [14C]dimethicone fluid in the hind limb of rats, the radioactivity was distributed primarily in the gastrointestinal tract, and no evidence of metabolism was observed. When [14C]dimethicone was administered through i.p. injection in rats, the following distribution of radioactivity was observed at 25 days after dosing: 51% in adipose tissue, 27% in gastrointestinal tissues, and 15% in liver 5.

Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half life
Not Available
Clearance
Not Available
Toxicity

The minimum lethal oral dose of dimethicone 200 (50 cs), dimethicone 550 (75 cs), dimethicone in rats 5.

A 76-week dietary toxicity study of a silicone antifoam compound (94% polydimethylsiloxane silicone oil and 6% silicone dioxide) was performed in mice. Three groups were given diet containing 0, 0.25%, or 2.5% of the test article. The dose levels in the treatment groups were estimated to be 580 and 5800 mg/kg/day. Mortality was increased in the 5800 mg/kg/day females. No target organs of toxicity were observed. The no-effect dose was 580 mg/kg/day. This study is of limited usefulness for assessing the toxicity of dimethicones, due to the small number of organs/tissues that were examined 5.

In one clinical study, 145 subjects were treated with either NYDA (dimethicone )or with a permethrin-based lice product. The number of subjects experiencing any adverse events was similar in both groups. In the NYDA group, 29 adverse events were reported in 25 subjects. All except two adverse events were categorized as being unrelated to the lice treatment (e.g., superficial wound after a fall, otitis externa following swimming in a pool). Two patients in the NYDA group experienced ocular irritation after treatment when the product entered the eyes. The irritation resolved spontaneously in both cases after rinsing the eyes with clean water 9.

Affected organisms
Not Available
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
Segesterone acetateThe serum concentration of Segesterone acetate can be increased when it is combined with Dimethicone.
Additional Data Available
  • Extended Description
    Extended Description

    Extended description of the mechanism of action and particular properties of each drug interaction.

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  • Severity
    Severity

    A severity rating for each drug interaction, from minor to major.

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  • Evidence Level
    Evidence Level

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  • Action
    Action

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Food Interactions
No interactions found.

References

General References
  1. Ingram RJ, Bartlett A, Brown MB, Marriott C, Whiffield RJ: Dimethicone barrier cream prevents infection of human skin by schistosome cercariae: evidence from Franz cell studies. J Parasitol. 2002 Apr;88(2):399-402. doi: 10.1645/0022-3395(2002)088[0399:DBCPIO]2.0.CO;2. [PubMed:12054019]
  2. Dimethicone [Link]
  3. Safety and efficacy of a 100 % dimethicone pediculocide in school-age children [Link]
  4. Public Assessment Report, Dimethicone [Link]
  5. CENTER FOR DRUG EVALUATION AND RESEARCH- 20755 [Link]
  6. Dimethicone [Link]
  7. Moisturel, Daily Med monograph [Link]
  8. Guidelines of care for the management of atopic dermatitis [Link]
  9. Product Monograph, NYDA [Link]
  10. POLYDIMETHYLSILOXANE [Link]
  11. Dimethicone [Link]
  12. DailyMed Label: DIMETHICONE, skin protectant cream [Link]
External Links
PubChem Substance
347911104
RxNav
324072
Wikipedia
Dimethicone
AHFS Codes
  • 56:10.00 — Antiflatulents
  • 84:24.12 — Basic Ointments and Protectants
  • 84:92.00 — Misc. Skin and Mucous Membrane Agents
  • 84:04.12 — Scabicides and Pediculicides

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedNot AvailableHealthy Volunteers1
1CompletedBasic ScienceHealthy Volunteers2
1CompletedPreventionIntradermal Electroporation1
1CompletedTreatmentHuman Immunodeficiency Virus (HIV) Infections1
1, 2TerminatedPreventionRadiodermatitis1
2CompletedNot AvailableAcid Reflux Disease / Gastro-esophageal Reflux Disease (GERD) / Heartburn / Regurgitation1
2CompletedTreatmentScalp Psoriasis1
2CompletedTreatmentLice of the head1
2RecruitingTreatmentBack Pain, Unspecified / Endometriosis / Fibromyalgia Syndrome / Interstitial Cystitis / Irritable Bowel Syndrome (IBS) / Migraine / Myalgic Encephalomyelitis (ME) / Temporomandibular Disorders / Tension Headache / Vestibulodynia1
3CompletedTreatmentFecal Incontinence1
3CompletedTreatmentSterility, Postpartum1
3RecruitingTreatmentDentin Hypersensitivity1
3RecruitingTreatmentDentine Hypersensitivity1
3RecruitingTreatmentDyspepsia1
4CompletedDiagnosticBowel preparation therapy / Colonoscopy1
4CompletedTreatmentDentin Sensitivity / Periodontal Diseases1
4CompletedTreatmentGastro-esophageal Reflux Disease (GERD)1
4RecruitingTreatmentAtopic Dermatitis (AD)1
4TerminatedTreatmentRelapsing Remitting Multiple Sclerosis (RRMS)1
Not AvailableCompletedOtherBubbles in Colon at Time of Colonoscopy1
Not AvailableCompletedTreatmentAtopic Dermatitis (AD)1
Not AvailableCompletedTreatmentPsoriasis1
Not AvailableCompletedTreatmentVitiligo1
Not AvailableTerminatedTreatmentDiaper Rash1
Not AvailableWithdrawnScreeningColorectal Cancers1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage forms
FormRouteStrength
CreamTopical0.3 g/30g
LipstickTopical0.76 g/6.4g
LipstickTopical0.006 g/1g
CreamTopical0.93 g/30mL
CreamTopical0.75 g/50mL
StickTopical0.1 g/100g
StickTopical0.85 g/100g
CreamTopical13000 mg/1L
Cream; kitTopical
CreamCutaneous0.5 mg/50mL
CreamCutaneous2 mg/100mL
CreamCutaneous1.2 mg/30mL
CreamTopical1.375 g/55mL
CreamTopical0.3 g/25mL
CreamTopical1.32 g/120mL
CreamTopical0.48 g/40mL
LotionTopical10 mg/1g
Capsule, liquid filledNot applicable125 mg/1
CreamTopical1.95 g/150mL
CreamTopical4 mg/1mL
CreamCutaneous0.9 g/45g
CreamCutaneous0.45 g/45g
CreamCutaneous0.45 mL/45mL
CreamTopical1.35 g/50mL
CreamTopical0.75 g/25mL
Tablet, chewableOral
LotionTopical30 mg/1mL
LotionTopical3.54 g/118mL
LotionTopical7.08 g/236mL
LotionTopical1.77 g/59mL
LotionTopical.03 mg/1mL
ClothTopical0.352 g/1
SuspensionOral
CreamTopical2.1 g/100mL
CreamTopical0.65 g/50g
CreamCutaneous0.51 mL/50mL
PatchTopical0.6 g/20g
LiquidOral21 mg/100mL
LotionTopical4.55 g/130mL
CreamTopical0.2 g/20g
OilTopical249.2 mg/1mL
CreamTopical1 g/100mL
CreamTopical0.01 g/100mL
SolutionTopical30 mg/300mL
CreamTopical20 mg/200mL
CreamTopical0.60 mg/60g
LotionTopical13 mg/1g
StickTopical10 mg/1g
CreamTopical12.5 mg/1g
CreamTopical13 mg/1g
KitTopical12 mg/1mL
LotionTopical12 mg/1mL
CreamTopical125 mg/1g
EmulsionTopical5 mg/1g
CreamTopical3 g/100g
LotionTopical1.2 g/100mL
LotionTopical0.5 g/100mL
LotionTopical
LotionTopical1.2 g/100g
SuspensionOral
CreamTopical0.2 g/1g
LotionTopical2 g/100mL
ClothTopical3 g/100g
LotionTopical20 mg/1g
CreamTopical1 g/50g
CreamTopical1.6 g/160g
LotionTopical1.25 g/100mL
LiquidTopical2.5 g/50mL
CreamTopical0.5 g/50mL
CreamTopical2.93 g/125mL
CreamTopical1.5 g/30mL
AerosolTopical2.7 g/100g
JellyTopical2 g/100g
CreamTopical2.25 g/150mL
CreamTopical1.25 g/50mL
CreamTopical0.3 g/30mL
CreamCutaneous2.72 g/50g
TabletOral125 mg/1
CreamTopical0.4 mg/50mL
CreamTopical1.02 mg/40mL
CreamCutaneous0.5 mL/50mL
CreamTopical4.27 g/95g
PatchTopical0.96 mg/32mL
CreamTopical0.015 g/1mL
CreamTopical0.15 g/15mL
Ointment; stickTopical
KitTopical
CreamTopical5.88 mg/5.88mL
CreamTopical4.4 g/44g
StickTopical0.01 g/1g
LiquidTopical2.5 g/100mL
CreamTopical0.5 g/50g
CreamTopical0.6 g/20g
CapsuleOral
LiquidTopical32 mg/100g
LiquidTopical3.2 g/100g
CreamTopical0.82 mg/55mL
EmulsionTopical1.20 mg/120mL
CreamTopical0.4 mg/40mL
CreamTopical0.25 mg/25mL
CreamTopical0.55 mg/55mL
CreamTopical2.2 g/55mL
CreamTopical1.2 g/60mL
CreamTopical2.4 g/60mL
CreamTopical0.7 mg/70mL
LotionTopical1.50 g/150mL
CreamTopical1.50 g/150mL
CreamTopical2.8 mg/140mL
CreamTopical0.51 mg/15mL
CreamTopical0.9 g/35mL
CreamTopical1.14 g/55mL
CreamTopical10.04 g/200mL
CreamTopical0.9 g/30mL
CreamTopical2.3 g/50mL
OintmentTopical0.36 g/30g
CreamTopical0.3 mg/30mL
CreamTopical12 mg/1g
LotionTopical10 mg/1mL
CreamTopical3.90 g/65mL
CreamTopical0.6 g/60mL
StickTopical
GelTopical20 mg/1g
CreamTopical6.0 mg/30mL
Liquid; sprayTopical
LiquidTopical1.52 mg/1mL
LotionTopical1.25 mg/100mL
ClothTopical30 mg/1g
GelTopical2.5 g/50mL
LiquidTopical3.6 g/120mL
CreamTopical0.57 g/57g
StickTopical0.66 g/8.5g
StickTopical1 g/100g
LiquidTopical12 mg/1mL
CreamTopical12.5 mg/1mL
SprayTopical1 g/100mL
LotionTopical12.12 mg/1mL
LotionTopical13.1 mg/1g
LotionTopical1.3 g/100g
LotionTopical1.3 kg/100kg
LotionTopical1.3 kg/100mL
LotionTopical13.13 mg/1mL
LotionTopical1.2500 mL/100mL
CreamTopical0.2 g/100g
CreamTopical2.92 g/75mL
Kit
LotionTopical0.01 g/1mL
CreamTopical3 g/100mL
CreamTopical.01 mg/1g
LotionTopical0.5 g/100g
LotionTopical1.0 g/100g
CreamTopical17.5 ug/1mg
CreamTopical50 ug/1mg
LiquidTopical17.5 ug/1mg
OintmentTopical
DiscTopical
LotionTopical4.50 mg/300mL
CreamTopical5.5 g/110mL
LiquidTopical1.5 g/30mL
CreamTopical6.0 g/100mL
LotionTopical1.1 g/100mL
CreamTopical
CreamTopical0.9 g/30g
OilTopical26 1/100mL
OilTopical1.5 1/150mL
CreamTopical11.5 g/50g
CreamTopical15 mg/1g
GelTopical1.27 g/100mL
CreamTopical6.0192 g/100mL
CreamTopical0.5 g/100mL
CreamTopical0.75 g/100mL
GelTopical0.01 g/100mL
LiquidTopical0.01 g/100mL
LiquidTopical1.2 g/100mL
CreamTopical4.0 g/400mL
Granule, effervescentOral
TabletOral40 mg/1
SolutionTopical12.0 mg/200mL
LiquidTopical9.60 g/200mL
LiquidTopical2.88 g/60mL
CreamTopical0.9 g/60mL
CreamTopical0.46 mg/40mL
CreamTopical0.9 g/45g
CreamTopical20 g/1000g
SolutionOral
LotionTopical13 mg/1mL
Suspension / dropsOral20 mg/0.3mL
GelTopical30 g/100mL
CreamCutaneous0.55 g/55g
LiquidOral125 mg/5mL
CreamCutaneous
Tablet, chewableOral80 mg/80mg
TabletOral80 mg/1
CreamTopical0.8 g/80mL
CreamTopical0.62 mg/20mL
PatchCutaneous4 g/100g
GelTopical2 g/100mL
LiquidTopical3.1 mg/155mL
LotionTopical0.5 mg/1mL
GelTopical3.2 g/100g
Aerosol, foamTopical1 g/100g
CreamTopical5.45 g/125mL
CreamTopical0.46 g/20mL
CreamTopical0.605 g/55mL
KitTopical1.5 g/100mL
CreamTopical2.5 mg/50mL
CreamCutaneous0.5 g/50g
CreamCutaneous2.65 mL/50mL
CreamCutaneous2.25 g/50g
CreamTopical1.39 g/55g
CreamTopical2.64 g/55g
CreamTopical1.88 g/50g
CreamTopical0.71 g/50g
CreamTopical1.54 g/55g
LotionTopical2.40 mg/130mL
CapsuleOral180 mg/1
StripOral62.5 mg/1
GelOral125 mg/1
GelOral
LotionTopical17.5 mg/1mL
CreamTopical17.5 mg/1mL
CreamTopical15 mg/1mL
CreamTopical50 mg/1mL
LiquidTopical0.4 mg/40mL
CreamTopical0.46 g/23mL
CreamCutaneous1.8 mL/45mL
CreamCutaneous3.51 mL/45mL
CreamCutaneous3.69 g/55g
CreamTopical10 mg/1g
CreamTopical0.2 g/50mL
CreamTopical2.0 g/50mL
CreamTopical0.2 g/40mL
CreamTopical1.0 g/50mL
CreamTopical0.83 mg/50mL
CreamTopical1.63 mg/40mL
ShampooTopical0.6 g/100mL
ShampooTopical4 mg/400mL
ShampooTopical2.4 mg/240mL
CreamTopical0.8 g/80g
GelTopical1 g/100mL
CreamTopical1.5 mL/100mL
CreamTopical1.50 g/60mL
CreamTopical1.01 g/30mL
GelTopical2 g/300g
GelTopical1.0 g/300g
EmulsionOral20 mg/0.3mL
CreamTopical0.5 g/100g
LiquidTopical3 g/100mL
CreamTopical1.04 g/50g
CreamTopical12.5 g/100mL
OintmentTopical17 g/56.69g
Lotion / shampooTopical
CreamTopical2.99 g/50mL
CreamTopical2.08 g/50mL
CreamCutaneous1.39 g/30mL
LotionTopical2.0 g/200mL
LotionTopical12.5 mg/1mL
SuspensionOral20 mg/0.3mL
LiquidOral20 mg/0.3mL
LotionTopical
LiquidTopical0.15 g/100g
CreamTopical1 mg/50mL
LotionTopical2.0 mg/200mL
CreamTopical0.96 mg/30mL
CreamTopical0.2 mg/20mL
CreamTopical0.95 mg/30mL
ShampooTopical1 g/100mL
ShampooTopical1.666667 g/100mL
LiquidTopical1 g/100mL
LiquidTopical0.06 g/1.5mL
CreamTopical0.04 g/1.5mL
LiquidTopical1.5 g/100mL
CreamTopical20 mg/1g
LiquidTopical1.5 mL/100mL
CreamTopical5.0 mL/100mL
LotionTopical1.5 mL/100mL
SprayTopical10.2 mg/1mL
LiquidTopical5 g/100mL
GelTopical0.2 g/10mL
CreamTopical0.75 mg/1mL
LipstickTopical
LipstickTopical6 g/100g
Tablet, chewableOral60 mg/1
TabletOral
CreamTopical0.58 g/50mL
CreamTopical1.02 g/50mL
Aerosol, foamTopical1 g/100mL
PatchTopical
Capsule, liquid filledOral250 mg/1
Tablet, chewableOral125 mg/1
CreamTopical0.1 g/100g
CreamTopical10 g/100g
CreamTopical1.5 g/50g
GelTopical1.05 g/50mL
LipstickTopical7.4 g/100g
CreamTopical1.62 mg/65mL
PatchTopical0.16 g/8g
Capsule, delayed releaseOral
CreamTopical0.3 g/75mL
CreamTopical3 mg/300mL
EmulsionTopical2 mg/200mL
PatchTopical0.22 mg/22mL
CreamTopical0.35 g/35g
CreamTopical2 mg/200mL
CreamTopical7.5 g/150mL
LotionTopical30 g/1g
ClothTopical
LotionTopical40 mg/1mL
Solution / dropsOral20 mg/0.3mL
GelTopical1.2 g/100g
GelTopical12 mg/1g
CreamTopical1 g/50mL
CreamTopical1.5 g/50mL
CreamTopical10 mg/1mL
LotionTopical4.8 mg/400mL
CreamTopical0.8 g/50mL
GelTopical
CreamTopical45 mg/1g
PatchTopical0.50 g/20g
StickTopical0.03 g/3.2g
LotionTopical.02 mL/1mL
CreamTopical.02 mL/1mL
CreamTopical1.7 mg/118mg
SolutionTopical
LiquidTopical1 mg/100mL
LotionTopical0.15 g/100g
LotionTopical1 g/100g
LotionTopical12 mg/1g
LotionTopical3 g/227g
CreamCutaneous2 g/50g
LiquidTopical0.03 mg/2.8mL
SolutionTopical
GelTopical0.024 g/1mL
CreamTopical7.06 g/50mL
StickTopical0.09 g/9g
LotionTopical2.70 g/180mL
LiquidOral
EmulsionOral
LiquidTopical1.10 g/110mL
Powder, for solutionOral
CreamTopical1.675 g/50g
SwabTopical3.2 g/100g
ClothTopical32 mg/1mL
Capsule, gelatin coatedOral180 mg/1
Capsule, gelatin coatedOral250 mg/1
Solution / dropsOral
LiquidOral
CreamTopical0.6 g/60g
CreamTopical1.0 g/20mL
Lotion15 mg/1mL
Cream15 mg/1mL
Cream25 mg/1mL
Capsule, gelatin coatedRectal; Vaginal0.324 g/1.2g
CreamTopical2.38 g/140mL
CreamTopical0.36 g/30mL
CreamTopical6.75 g/50mL
CreamTopical1.4 g/140mL
CreamTopical1 g/100g
CreamTopical1.6 g/80g
CreamTopical2 g/100g
LotionTopical3 mg/150mL
CreamCutaneous1.8 mL/130mL
CreamTopical1.1 g/55mL
CreamTopical0.55 g/50mL
SolutionTopical0.72 g/40mL
SwabTopical32 mg/1g
EmulsionTopical2.6 mg/130mL
CreamTopical2.1 mg/60mL
CreamTopical3.05 g/30mL
CreamTopical1.5 mg/30mL
PowderTopical2.16 g/12g
CreamTopical0.9 mg/30mL
PowderTopical1.85 g/12g
CreamTopical20 mg/1mL
CreamTopical0.01 g/1g
OintmentTopical
OintmentTopical0.01 g/1g
CreamTopical1.6 g/80mL
CreamTopical5.41 g/50g
CreamTopical1.25 g/50g
LiquidTopical0.9 g/45mL
CreamTopical8 g/100mL
LiquidTopical8 g/100mL
LiquidTopical53.1 g/100mL
CreamTopical0.3 g/100mL
SprayTopical
LiquidTopical
ClothTopical0.608 g/1
ClothTopical0.544 g/1
ClothTopical0.294 g/1
ClothTopical3.2 g/100mL
CreamTopical0.5 mg/100mL
CreamTopical0.4 g/100mL
ShampooTopical2 g/100mL
OilTopical1.2 g/30mL
CreamTopical2.66 g/140mL
CreamTopical1.6 g/40mL
CreamTopical2 g/80mL
ClothTopical3.6 g/100mL
LotionTopical1.5 g/100mL
LotionTopical1.5 mg/100mL
LotionTopical0.01 g/1g
CreamTopical0.05 g/100g
CreamTopical0.015 g/100g
CreamTopical1.5 g/100mL
CreamTopical1.61 mg/50mL
CreamTopical0.32 g/10mL
CreamTopical1.75 mg/70mL
EmulsionTopical1.3 mg/130mL
CreamTopical0.75 mg/50mL
CreamTopical0.15 g/10mL
EmulsionTopical0.2 g/20mL
CreamTopical0.15 mg/15mL
CreamTopical0.03 g/3mL
LiquidTopical1.1 mg/110mL
PatchTopical0.6 g/30mL
LiquidTopical12.5 mg/1mL
Bar, chewableOral
CreamTopical0.6 g/30g
CreamTopical2.49 g/120mL
LiquidTopical2.49 g/120mL
CreamTopical0.54 g/50mL
CreamTopical1.8 g/100mL
GelTopical1 mg/100mg
LotionTopical1.25 mL/100mL
CreamTopical1.133 g/113g
CreamTopical960 mg/96g
CreamTopical0.42 mg/21mL
CreamTopical0.4988 mg/21mL
LotionTopical50 mg/1mL
PowderTopical0.02 g/10g
CreamTopical0.24 mg/80mL
CreamTopical50 mg/1g
CreamTopical1.0 g/100mL
CreamTopical1.0 mg/100mL
PowderTopical0.08 g/4.5g
PowderTopical0.07 g/4.5g
GelTopical2.1 g/7.5mL
PowderTopical1.05 g/10g
CreamTopical
CreamTopical2.5 g/100mL
Capsule, liquid filledOral125 mg/1
Capsule, liquid filledOral180 mg/1
Solution / dropsOral
Tablet, chewableOral80 mg/1
GelTopical.0024 mg/.024mg
GelTopical.00119 mg/.119mg
GelTopical0.6 mg/60mg
CreamTopical1.04 mg/50mL
LotionTopical1 mL/100mL
LotionTopical1.0000 mL/100mL
LiquidTopical1.3 mL/100mL
LotionTopical5 mg/354mg
OintmentTopical2.272 g/113.6g
StickTopical1 mg/100mg
GelTopical1.61 g/50mL
CreamTopical0.5 mg/50mL
EmulsionTopical1.30 mg/120mL
CreamTopical1.07 mg/40mL
EmulsionTopical1.5 g/150mL
CreamTopical0.6 g/30mL
CreamTopical0.60 mg/30mL
CreamTopical0.99 g/55mL
EmulsionTopical1.30 g/120mL
CreamTopical1.07 g/40mL
GelTopical1.6 g/100mL
CreamTopical1.04 mg/55mL
CreamTopical1.6 g/100mL
CreamTopical0.968 g/40mL
CreamTopical0.77 g/55mL
SolutionTopical0.3 g/30mL
CreamTopical1.296 g/120mL
CreamTopical1.2 g/120mL
CreamTopical1.65 g/55mL
CreamTopical0.76 g/40mL
CreamTopical0.4 g/40mL
CreamTopical0.375 g/25mL
StickTopical20 mg/1g
CreamTopical5 g/100mL
CreamTopical9.75 g/150mL
CreamTopical1.35 g/30mL
LiquidTopical5.4 g/135mL
CreamTopical5.0 g/100mL
CreamTopical1.5 g/75mL
PowderTopical0.12 g/6g
PowderTopical0.06 g/6g
StickTopical0.18 g/1.5g
CreamTopical1.2 g/60g
CreamTopical1.44 g/120g
CreamTopical2.56 g/160mL
CreamTopical13 mg/1mL
CreamTopical1.6 mg/80mL
CreamTopical2 g/100mL
CreamTopical6.8 mg/80mL
CreamTopical0.3 g/20mL
CreamTopical1.575 g/35mL
CreamTopical1.5 g/150mL
CreamCutaneous0.58 mL/45mL
CreamCutaneous0.7 mL/35mL
CreamTopical60 mg/1g
CreamTopical.01 g/100mL
CreamTopical.012 g/100mL
LotionTopical1.5 g/150mL
CreamTopical0.5 g/25mL
GelTopical1.5 g/100mL
CreamTopical1.55 g/50mL
CreamTopical0.81 g/30mL
CreamTopical50 uL/1mL
CreamTopical17.5 uL/1mL
LiquidTopical17.5 uL/1mL
CreamTopical1.7 g/170.10g
CreamTopical0.044 g/4mL
CreamTopical0.77 g/70mL
CreamTopical1.5 mg/50mL
CreamTopical1.4 mg/140mL
CreamTopical7 mg/35mL
CreamTopical0.6 mg/30mL
TabletOral
GelTopical30 mg/1mL
CreamTopical0.45 mg/45mL
Injectable foamTopical
CreamTopical2.10 g/60mL
EmulsionTopical
SprayTopical20 g/100g
ShampooTopical11.4 mg/380mL
SolutionTopical15.2 mg/380mL
LotionTopical2 g/100g
CreamTopical5 g/100g
CreamTopical0.64 g/40mL
CreamTopical1.65 g/150mL
CreamTopical2 g/40mL
CreamTopical0.75 g/30mL
CreamTopical3.6 g/90mL
CreamTopical7 g/100mL
CreamTopical3.81 g/50mL
EmulsionTopical0.937 mg/50mL
OintmentTopical10 mg/1g
OintmentTopical20 mg/1g
LotionTopical1 g/100mL
LotionTopical15 mg/1mL
CreamTopical25 mg/1g
EmulsionTopical1.50 g/150mL
CreamTopical1.57 g/35mL
LipstickTopical0.91 g/4.5g
LiquidTopical0.05 g/7g
LiquidTopical3.77 g/7g
CreamTopical0.32 g/30mL
CreamTopical1.12 g/50mL
CreamCutaneous0.35 mL/35mL
LiquidTopical99.97 g/100mL
CreamCutaneous0.3 g/30g
PasteTopical
Prices
Not Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)
US6103260No2000-08-152017-07-17Us
Additional Data Available
  • Filed On
    Filed On

    The date on which a patent was filed with the relevant government.

    Learn more

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Taxonomy

Classification
Not classified

Drug created on December 03, 2015 09:51 / Updated on May 30, 2020 00:22

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