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Displaying drugs 201 - 225 of 11274 in total

Phenytoin

Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for several other indications such as...
Approved
Vet approved
Matched Description: … Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one …
Matched Categories: … UGT1A1 Substrates with a Narrow Therapeutic Index ... UGT1A6 Substrates with a Narrow Therapeutic Index ... UGT1A9 Substrates with a Narrow Therapeutic Index ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2A6 Substrates with a Narrow Therapeutic Index …

Ponatinib

Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012.
Approved
Investigational
Matched Description: … Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index …

Sitagliptin

Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improve control of blood sugar[FDA label,A2255]....
Approved
Investigational
Matched Iupac: … (3R)-3-amino-1-[3-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl …

Sodium molybdate

Approved
Experimental
Matched Mixtures name: … One-A-day Advance Men's …

Theophylline

A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under several brand names such as Uniphyl and Theochron, and it is indicated mainly...
Approved
Matched Description: … A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac ... Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and …
Matched Mixtures name: … TUSBRON-A JARABE …
Matched Categories: … Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2E1 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Chromic chloride

Chromic chloride, for injection, is a sterile, nonpyrogenic solution intended for use as an additive to solutions for Total Parenteral Nutrition (TPN).
Approved
Matched Description: … Chromic chloride, for injection, is a sterile, nonpyrogenic solution intended for use as an additive …
Matched Mixtures name: … One-A-day Advance Men's …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Ferrous sulfate anhydrous

Iron deficiency anemia is a large public health concern worldwide, especially in young children, infants, and women of childbearing age. This type of anemia occurs when iron intake, iron stores, and iron loss do not adequately support the formation of erythrocytes, also known as red blood cells. Ferrous sulfate is...
Approved
Matched Description: … [A190528] Ferrous sulfate is a synthetic agent used in the treatment of iron deficiency. ... Iron deficiency anemia is a large public health concern worldwide, especially in young children, infants …
Matched Mixtures name: … Phytofortis + Calcium A-D …

Tamoxifen

Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment for these types of cancers...
Approved
Matched Description: … Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as …
Matched Categories: … UGT2B7 Substrates with a Narrow Therapeutic Index ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2A6 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2B6 Substrates with a Narrow Therapeutic Index …

Methyl salicylate

Methyl salicylate (oil of wintergreen or wintergreen oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. The compound was first extracted and isolated from plant species Gaultheria procumbens in 1843. It can be manufactured synthetically and it used as a fragrance, in foods, beverages, and...
Approved
Vet approved
Matched Description: … It forms a colorless to yellow or reddish liquid and exhibits a characteristic odor and taste of wintergreen ... It can be manufactured synthetically and it used as a fragrance, in foods, beverages, and liniments. ... It is used as a flavoring agent in chewing gums and mints in small concentrations and added as antiseptic …
Matched Mixtures name: … Cho-A Point Plaster ... Cho-A Point Plaster ... Pain-A-trate Cream …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Phenelzine

Phenelzine, with the formula β-phenylethylhydrazine, is a monoamine oxidase inhibiting antidepressant that is effective in the treatment of panic disorder and social anxiety disorder. It was developed by Parke Davis and originally FDA approved on June 9th, 1961. It is currently approved under prescription by the name of Nardil.
Approved
Matched Description: … Phenelzine, with the formula β-phenylethylhydrazine, is a monoamine oxidase inhibiting antidepressant …
Matched Categories: … Monoamine Oxidase A Substrates …

Metyrapone

An inhibitor of the enzyme steroid 11-beta-monooxygenase. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of cushing syndrome.
Approved
Investigational
Matched Description: … It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of cushing syndrome …

2-mercaptobenzothiazole

Approved
Experimental
Vet approved

Trimethoprim

Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a critical enzyme that catalyzes the formation of tetrahydrofolic acid (THF) - in doing so, it prevents the synthesis of bacterial DNA and ultimately continued bacterial survival. Trimethoprim is often used in combination with sulfamethoxazole due to their...
Approved
Vet approved
Matched Description: … Trimethoprim is an antifolate antibacterial agent that inhibits bacterial dihydrofolate reductase (DHFR), a ... combination with [sulfamethoxazole] due to their complementary and synergistic mechanisms but may be used as a …

Cetrimonium

Cetrimonium is a quaternary ammonium cation whose salts are used as antiseptics.
Approved
Matched Description: … Cetrimonium is a quaternary ammonium cation whose salts are used as antiseptics. …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Polyethylene glycol 300

Polyethylene glycol 300 (PEG 300) is a water-miscible polyether with an average molecular weight of 300 g/mol. It is a clear viscous liquid at room temperature with non-volatile, stable properties . Polyethylene glycols are widely used in biochemistry, structural biology, and medicine in addition to pharmaceutical and chemical industries. They...
Approved
Matched Description: … It is a clear viscous liquid at room temperature with non-volatile, stable properties [A33116]. ... Polyethylene glycol 300 (PEG 300) is a water-miscible polyether with an average molecular weight of 300 ... PEG 300 is found in eye drops as a lubricant to temporarily relieve redness, burning and irritation of …
Matched Categories: … Compounds used in a research, industrial, or household setting …

Hydroxyethyl ethylcellulose

Hydroxyethyl ethylcellulose modulates bacterial binding to salivary pellicle; moderately effective in preventing plaque formation.
Approved
Experimental
Matched Categories: … Compounds used in a research, industrial, or household setting …

Dichromate

Approved
Investigational
Matched Categories: … Compounds used in a research, industrial, or household setting …

Digoxin

Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also...
Approved
Matched Iupac: … yl]oxy}-4-hydroxy-6-methyloxan-2-yl]oxy}-3a,11-dihydroxy-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a] …
Matched Description: … [A178225] It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. ... [A178234] Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. ... [A178237,A178240] Prior to this, a Welsh family, historically referred to as the _Physicians of Myddvai …
Matched Categories: … BSEP/ABCB11 Substrates with a Narrow Therapeutic Index ... P-glycoprotein substrates with a Narrow Therapeutic Index ... Compounds used in a research, industrial, or household setting ... Drugs that are Mainly Renally Excreted with a Narrow Therapeutic Index …

Pseudoephedrine

Pseudoephedrine is structurally related to ephedrine but exerts a weaker effect on the sympathetic nervous system.[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. The decongestant effect of pseudoephedrine was described...
Approved
Matched Description: … Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic ... [A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional …
Matched Mixtures name: … Ed-A-hist Pse ... BRONKAR-A 100 ML SURUP ... A-FERIN DECO ŞURUP, 100 ML …
Matched Categories: … Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates …

Ferric carboxymaltose

Ferric carboxymaltose is an iron replacement product and, chemically, an iron-carbohydrate complex. It was FDA approved on July 25, 2013.
Approved
Matched Categories: … Compounds used in a research, industrial, or household setting …

Nickel sulfate

Nickel sulfate is used in allergenic testing.
Approved
Experimental
Matched Categories: … Compounds used in a research, industrial, or household setting …

Cobalt chloride

Approved
Experimental
Matched Categories: … Compounds used in a research, industrial, or household setting …

Digitoxin

A cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665)
Approved
Investigational
Matched Iupac: … methyloxan-2-yl]oxy}-4-hydroxy-6-methyloxan-2-yl]oxy}-3a-hydroxy-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a] …
Matched Description: … A cardiac glycoside sometimes used in place of digoxin. ... It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer …
Matched Categories: … P-glycoprotein substrates with a Narrow Therapeutic Index ... Compounds used in a research, industrial, or household setting ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index …

Tedizolid phosphate

Drug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and penicillin-resistant Streptococcus penumoniae, represent a massive public health threat.[A199086, A199131] Tedizolid is a member of the oxazolidinone class of antibiotics, which includes the previously approved linezolid and is generally effective against multidrug-resistant Gram-positive bacteria. Tedizolid is indicated for the...
Approved
Matched Description: … [A199086, A199131] Tedizolid is a member of the oxazolidinone class of antibiotics, which includes the ... vancomycin-resistant _Enterococcus faecium_, and penicillin-resistant _Streptococcus penumoniae_, represent a ... This product is currently available as both an oral tablet and as a powder for intravenous injection. …
Matched Categories: … Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates …

Astemizole

Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice.
Approved
Withdrawn
Matched Description: … Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy …
Matched Categories: … BSEP/ABCB11 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index ... Cytochrome P-450 CYP3A7 Substrates with a Narrow Therapeutic Index …
Displaying drugs 201 - 225 of 11274 in total